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https://www.readbyqxmd.com/read/29667617/combination-of-stromal-vascular-fraction-and-ad-comp-ang1-gene-therapy-improves-long-term-therapeutic-efficacy-for-diabetes-induced-erectile-dysfunction
#1
Guo-Nan Yin, Lin Wang, Xiang-Nan Lin, Lei Shi, Zhen-Lin Gao, Feng-Chan Han, Ping Li, Yin-Chuan Jin, Jun-Kyu Suh, Ji-Kan Ryu, Xiong Wang, Hai-Rong Jin
Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects...
April 17, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29656237/vascularized-microfluidic-organ-chips-for-drug-screening-disease-models-and-tissue-engineering
#2
REVIEW
Tatsuya Osaki, Vivek Sivathanu, Roger D Kamm
Vascularization of micro-tissues in vitro has enabled formation of tissues larger than those limited by diffusion with appropriate nutrient/gas exchange as well as waste elimination. Furthermore, angiocrine signaling from the vasculature may be essential in mimicking organ-level functions in these micro-tissues. In drug screening applications, the presence of an appropriate blood-organ barrier in the form of a vasculature and its supporting cells (pericytes, appropriate stromal cells) may be essential to reproducing organ-scale drug delivery pharmacokinetics...
April 12, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29655605/physiology-and-pathophysiology-of-renal-erythropoietin-producing-cells
#3
REVIEW
Hong-Mou Shih, Chih-Jen Wu, Shuei-Liong Lin
Anemia is a common complication and contributes to increased morbidity and mortality in chronic kidney disease (CKD) patients. Whereas there has been a significant improvement of understanding the underlying mechanism of erythropoiesis, the treatment of renal anemia is still restricted to erythropoietin (EPO)-stimulating agents. The purpose of this article is to review the physiology of erythropoiesis, functional role of EPO and underlying molecular and cellular basis that regulate EPO production. Regulation of EPO production is at mRNA level...
April 11, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29650962/vascular-endothelial-growth-factor-mediates-the-therapeutic-efficacy-of-mesenchymal-stem-cell-derived-extracellular-vesicles-against-neonatal-hyperoxic-lung-injury
#4
So Yoon Ahn, Won Soon Park, Young Eun Kim, Dong Kyung Sung, Se In Sung, Jee Yin Ahn, Yun Sil Chang
We previously reported the role of vascular endothelial growth factor (VEGF) secreted by mesenchymal stem cells (MSCs) in protecting against neonatal hyperoxic lung injuries. Recently, the paracrine protective effect of MSCs was reported to be primarily mediated by extracellular vesicle (EV) secretion. However, the therapeutic efficacy of MSC-derived EVs and the role of the VEGF contained within EVs in neonatal hyperoxic lung injury have not been elucidated. The aim of the study was to determine whether MSC-derived EVs attenuate neonatal hyperoxic lung injury and, if so, whether this protection is mediated via the transfer of VEGF...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29648877/role-of-mitophagy-regulation-by-ros-in-hepatic-stellate-cells-during-acute-liver-failure
#5
Zhen Tian, Yi Chen, Naijuan Yao, Chunhua Hu, Yuchao Wu, Dandan Guo, Jinfeng Liu, Yuan Yang, Tianyan Chen, Yingren Zhao, Yingli He
Liver sinusoids serve as the first line of defence against extrahepatic stimuli from the intestinal tract. Hepatic stellate cells (HSCs) are pericytes residing in the perisinusoidal space that integrate cytokine-mediated inflammatory responses in the sinusoids and relay these signals to the liver parenchyma. Oxidative stress has been shown to promote inflammation during acute liver failure (ALF). Whether and how oxidative stress is involved in HSC inflammation during ALF remains unclear. Level of systemic oxidative stress is reflected by superoxide dismutase (SOD)...
April 12, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29629621/pdgfr-%C3%AE-restores-blood-brain-barrier-functions-in-a-mouse-model-of-focal-cerebral-ischemia
#6
Jie Shen, Guihua Xu, Runxiu Zhu, Jun Yuan, Yoko Ishii, Takeru Hamashima, Takako Matsushima, Seiji Yamamoto, Yusuke Takatsuru, Junichi Nabekura, Masakiyo Sasahara
Although platelet-derived growth factor receptor beta (PDGFR-β) mediates the recruitment of vascular pericytes into ischemic lesion to restore the blood-brain barrier (BBB) dysfunction, its mechanisms still remain elusive . Compared with control PDGFR-βfloxed / floxed mice (Floxed), postnatally induced systemic PDGFR-β knockout mice (Esr-KO) not only showed severe brain edema, neurologic functional deficits, decreased expression of tight junction (TJ) proteins, abundant endothelial transcytosis, and deformed TJs in the BBB, but also showed reduced expression of transforming growth factor-β (TGF-β) protein after photothrombotic middle cerebral artery occlusion (MCAO)...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29626542/no-gc-in-cells-off-the-beaten-track
#7
REVIEW
Andreas Friebe, Barbara Voußen, Dieter Groneberg
Nitric oxide-sensitive guanylyl cyclase (NO-GC) has been shown to regulate a plethora of different functions in the body. These include, among many others, the fine-tuning of vascular tone, platelet reactivity and gastrointestinal motility. Evidence for the participation of NO-GC in these functions has been obtained from various species including humans, rodents, as well as insects. Clearly, individual cell types that express NO-GC contribute differentially to organ-specific NO/cGMP signaling in the body. Hence, identification of NO-GC-expressing cells and their individual involvement in NO/cGMP signaling constituted the focus of many studies over the last 40 years...
April 4, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29626067/endothelial-c-type-natriuretic-peptide-acts-on-pericytes-to-regulate-microcirculatory-flow-and-blood-pressure
#8
Katarina Špiranec, Wen Chen, Franziska Werner, Viacheslav O Nikolaev, Takashi Naruke, Franziska Koch, Andrea Werner, Petra Eder-Negrin, Rodrigo Diéguez-Hurtado, Ralf H Adams, Hideo A Baba, Hannes Schmidt, Kai Schuh, Boris V Skryabin, Kiavash Movahedi, Frank Schweda, Michaela Kuhn
Background -Peripheral vascular resistance has a major impact on arterial blood pressure levels. Endothelial C-type natriuretic peptide (CNP) participates in the local regulation of vascular tone but the target cells remain controversial. The cGMP-producing guanylyl cyclase-B (GC-B) receptor for CNP is expressed in vascular smooth muscle cells (VSMC). However, whereas endothelial cell-specific CNP knockout mice are hypertensive, mice with deletion of GC-B in VSMC have unaltered blood pressure. Methods -We analyzed whether the vasodilating response to CNP changes along the vascular tree, i...
April 6, 2018: Circulation
https://www.readbyqxmd.com/read/29623199/the-physiological-functions-of-central-nervous-system-pericytes-and-a-potential-role-in-pain
#9
REVIEW
Nicholas Beazley-Long, Alexandra M Durrant, Matthew N Swift, Lucy F Donaldson
Central nervous system (CNS) pericytes regulate critical functions of the neurovascular unit in health and disease. CNS pericytes are an attractive pharmacological target for their position within the neurovasculature and for their role in neuroinflammation. Whether the function of CNS pericytes also affects pain states and nociceptive mechanisms is currently not understood. Could it be that pericytes hold the key to pain associated with CNS blood vessel dysfunction? This article reviews recent findings on the important physiological functions of CNS pericytes and highlights how these neurovascular functions could be linked to pain states...
2018: F1000Research
https://www.readbyqxmd.com/read/29622551/choroidal-pericytes-promote-subretinal-fibrosis-after-experimental-photocoagulation
#10
Xueting Luo, Shiqi Yang, Jian Liang, Yuanqi Zhai, Mengxi Shen, Junran Sun, Yiji Feng, Xinmin Lu, Hong Zhu, Fenghua Wang, Xiaodong Sun
Subretinal fibrosis results in local destruction of retinal structures and permanent vision loss, representing the end stage of neovascular age-related macular degeneration (AMD). Histological examination of fibrotic specimens from AMD patients has uncovered a wide range of cellular and acellular components. However, their origins and roles in fibrosis remain largely unexplored. Using laser-induced photocoagulation model with Collagen 1α1-GFP reporter mice, we demonstrate by cell-lineage tracing that a subset of pericytes associating with choroidal microvasculature are activated upon injury and infiltrate into subretinal space as significant components of fibrotic lesions...
April 4, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29618365/apolipoprotein-e4-impairs-spontaneous-blood-brain-barrier-repair-following-traumatic-brain-injury
#11
Bevan S Main, Sonia Villapol, Stephanie S Sloley, David J Barton, Maia Parsadanian, Chinyere Agbaegbu, Kathryn Stefos, Mondona S McCann, Patricia M Washington, Olga C Rodriguez, Mark P Burns
BACKGROUND: Traumatic Brain Injury (TBI) is a major cause of disability and mortality, to which there is currently no comprehensive treatment. Blood Brain Barrier (BBB) dysfunction is well documented in human TBI patients, yet the molecular mechanisms that underlie this neurovascular unit (NVU) pathology remains unclear. The apolipoprotein-E (apoE) protein has been implicated in controlling BBB integrity in an isoform dependent manner, via suppression of Cyclophilin A (CypA)-Matrix metallopeptidase-9 (MMP-9) signaling cascades, however the contribution of this pathway in TBI-induced BBB permeability is not fully investigated...
April 4, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29606893/first-in-man-intravenous-implantation-of-stromal-vascular-fraction-in-psoriasis-a-case-study
#12
Kristin Comella, Michelle Parlo, Rosemary Daly, Kellie Dominessy
Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29603739/vascular-targeting-of-light-normalizes-blood-vessels-in-primary-brain-cancer-and-induces-intratumoral-high-endothelial-venules
#13
Bo He, Arnaud Jabouille, Veronica Steri, Anna Johansson-Percival, Iacovos P Michael, Venkata Ramana Kotamraju, Reimar Junckerstorff, Anna K Nowak, Juliana Hamzah, Gabriel Lee, Gabriele Bergers, Ruth Ganss
High grade brain cancer such as glioblastoma (GBM) remains an incurable disease. A common feature of GBM is the angiogenic vasculature which can be targeted with selected peptides for payload delivery. We assessed the ability of micelle-tagged, vascular homing peptides RGR, CGKRK or NGR to specifically bind to blood vessels in syngeneic orthotopic GBM models. By using the peptide CGKRK to deliver the TNF superfamily member LIGHT (also known as tumor necrosis factor superfamily member 14; TNFSF14) to angiogenic tumour vessels we have generated a reagent which normalizes the brain cancer vasculature by inducing pericyte contractility and re-establishing endothelial barrier integrity...
March 30, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29600169/mechanism-of-retinal-pericyte-migration-through-angiopoietin-tie-2-signaling-pathway-on-diabetic-rats
#14
Nadia Artha Dewi, Aulanni'am Aulanni'am, Hidayat Sujuti, Muhammad Aris Widodo, Djoko Wahono Soeatmadji
AIM: To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway. METHODS: We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor, and DMSO intravitreal. Retinal digest preparation was done to examine the retinal vasculature including pericyte: endothelial ratio, and morphology of pericyte migration. Tie-2, ERK1/2 and Akt/PKB phosporylation were analyzed by confocal laser scanning microscopy...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29598904/lipopolysaccharide-induces-subacute-cerebral-microhemorrhages-with-involvement-of-nitric-oxide-synthase-in-rats
#15
Jing Zeng, Hóngyi Zhào, Zhixin Liu, Weiwei Zhang, Yonghua Huang
BACKGROUND: Cerebral microhemorrhage (CMH) is a neuropathological term that could be easily found in cerebral amyloid angiopathy, intracerebral hemorrhages, etc. CMHs could be detected clearly in vivo by magnetic resonance imaging (MRI)-susceptibility-weighted imaging or MRI T2* scan. This terminology is now accepted in the area of neuroimaging. CMHs are quite common in elderly patients and are associated with several other neuropsychiatric disorders. The causes of CMHs are complicated, and neuroinflammation is considered as one of the well-accepted mechanical factors...
March 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29596849/histochemical-characteristics-of-regressing-vessels-in-the-hyaloid-vascular-system-of-neonatal-mice-novel-implication-for-vascular-atrophy
#16
Ayuko Kishimoto, Shunsuke Kimura, Junko Nio-Kobayashi, Hiromi Takahashi-Iwanaga, Ah-Mee Park, Toshihiko Iwanaga
The hyaloid vasculature constitutes a transitory system nourishing the internal structures of the developing eye, but the mechanism of vascular regression and its cell biological characteristics are not fully understood. The present study aimed to reveal the specificity of the hyaloid vessels by a systematic immunohistochemical approach for marker substances of myeloid cells and the extracellular matrix (ECM) in neonatal mice. Macrophages immunoreactive for F4/80, cathepsin D, and LYVE-1 gathered around the vasa hyaloidea propria (VHP), while small round cells in vascular lumen of VHP were selectively immunoreactive for galectin-3; their segmented nuclei and immunoreactivities for Ly-6G, CD11b, and myeloperoxidase indicated their neutrophilic origin...
March 26, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29596087/analysis-of-follicle-stimulating-hormone-receptor-in-infantile-hemangioma
#17
Reid A Maclellan, Dennis J Konczyk, Jeremy A Goss, Arin K Greene
INTRODUCTION: The life cycle of infantile hemangioma (IH) and secretion of follicle-stimulating hormone (FSH) are identical. We previously have shown that IH contains the FSH receptor (FSHR). The purpose of this study was to identify which cell type(s) in IH expresses FSHR. METHODS: Human proliferating IH tissues obtained during a clinically indicated surgical procedure were used. Paraffin sections and isolated cell populations (endothelial, pericyte, stem cell) were subjected to immunofluorescence for FSHR...
March 29, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29593101/thalidomide-reduces-hemorrhage-of-brain-arteriovenous-malformations-in-a-mouse-model
#18
Wan Zhu, Wanqiu Chen, Dingquan Zou, Liang Wang, Chen Bao, Lei Zhan, Daniel Saw, Sen Wang, Ethan Winkler, Zhengxi Li, Meng Zhang, Fanxia Shen, Sonali Shaligram, Michael Lawton, Hua Su
BACKGROUND AND PURPOSE: Brain arteriovenous malformation (bAVM) is an important risk factor for intracranial hemorrhage. Current treatments for bAVM are all associated with considerable risks. There is no safe method to prevent bAVM hemorrhage. Thalidomide reduces nose bleeding in patients with hereditary hemorrhagic telangiectasia, an inherited disorder characterized by vascular malformations. In this study, we tested whether thalidomide and its less toxic analog, lenalidomide, reduce bAVM hemorrhage using a mouse model...
March 28, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29592525/meis1-is-specifically-upregulated-in-kidney-myofibroblasts-during-aging-and-injury-but-is-not-required-for-kidney-homeostasis-or-fibrotic-response
#19
Monica Chang-Panesso, Farid F Kadyrov, Flavia G Machado, Ashish Kumar, Benjamin D Humphreys
The homeobox transcription factor Meis1 is required for mammalian development and its overexpression plays a role in tumorigenesis, especially leukemia. Meis1 is known to be expressed in kidney stroma, but its function in kidney is undefined. We hypothesized that Meis1 may regulate stromal cell proliferation in kidney development and disease, and tested this using cell lineage tracing and cell specific Meis1 deletion in development, aging and fibrotic disease. We observed strong expression of Meis1 in PDGFRβ positive pericytes and perivascular fibroblasts, both in adult mouse and to a lesser degree in human kidney...
March 28, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29590646/human-glioblastoma-derived-mesenchymal-stem-cell-to-pericytes-transition-and-angiogenic-capacity-in-glioblastoma-microenvironment
#20
Dongye Yi, Wei Xiang, Qing Zhang, Yongcun Cen, Qing Su, Fangcheng Zhang, Yinping Lu, Hongyang Zhao, Peng Fu
BACKGROUND/AIMS: Tumor vascular formation and maintenance are crucial events in glioblastoma development. Mesenchymal stem cells (MSCs) have been shown to differentiate into pericytes and contribute to neovascularization in the glioma microenvironment. Moreover, glioblastoma-derived mesenchymal stem cells (gb-MSCs), which consist of CD90-MSCs and CD90+MSCs, are a subpopulation of MSCs that are more active in glioma vascularization. However, the functions of gb-MSCs and the microRNA (miRNA) modifications in the glioblastoma microenvironment have not yet been fully elucidated...
March 22, 2018: Cellular Physiology and Biochemistry
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