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https://www.readbyqxmd.com/read/27873446/the-first-two-years-of-activity-of-a-specialized-organ-procurement-centre-report-of-an-innovative-approach-to-improve-organ-donation
#1
Pierre Marsolais, Philippe Durand, Emmanuel Charbonney, Karim Serri, Anne-Marie Lagacé, Francis Bernard, Martin Albert
The number of patients requiring organ transplants continues to outgrow the number of organs donated each year. In an attempt to improve the organ donation process and increase the number of organs available, we created a specialized multidisciplinary team within a specialized Organ Procurement Centre (OPC) with dedicated intensive care unit beds and operating rooms. The OPC was staffed with ICU nurses, operating room nurses, organ donor management ICU physicians and multidisciplinary staff. All organ donors within a designated geographic area were transferred and managed within the OPC...
November 22, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27739151/feasibility-of-routine-ferritin-testing-for-donor-management-validation-of-delayed-processing-and-demonstration-of-within-donor-reproducibility-over-time
#2
Mars Stone, Donald Brambilla, Karla Murcia, Melanie Dimapasoc, Sherri Cyrus, Ritchard G Cable, Joseph E Kiss, Michael P Busch
BACKGROUND: Understanding the effect of delayed processing of whole blood on plasma ferritin will inform the feasibility of both routine ferritin testing in donors and clinical research study design. STUDY DESIGN AND METHODS: Whole blood tubes drawn from 16 donors were held at 4°C and centrifuged at 24-hour intervals to assess plasma ferritin concentration up to 5 days after draw. Intraindividual variation over time was measured in 21 healthy donors in blood samples collected weekly for 4 weeks and then at 12 weeks...
October 2016: Transfusion
https://www.readbyqxmd.com/read/27727092/-deceased-donation-in-renal-transplantation
#3
R Thuret, F Kleinclauss, N Terrier, M O Timsit
OBJECTIVES: To review epidemiologic data's and medical results of deceased donation in renal transplantation. MATERIAL AND METHODS: Relevant publications were identified through Medline (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) database using the following keywords, alone or in association, "brain death; cardiac arrest; deceased donation; organ procurement; transplantation". Articles were selected according to methods, language of publication and relevance...
October 7, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27726211/thyroid-hormone-use-during-cardiac-transplant-organ-procurement
#4
Lauren B Cooper, Carmelo A Milano, Melissa Williams, Wendy Swafford, Donna Croezen, Adrian B Van Bakel, Joseph G Rogers, Chetan B Patel
BACKGROUND: Acute hypothyroidism after brain death results in hemodynamic impairments that limit availability of donor hearts. Thyroid hormone infusions can halt that process and lead to increased utilization of donor organs, but prolonged use of thyroid replacement has not been well studied. METHODS: We developed a 15-question survey regarding policies, procedures, and reporting of thyroid hormone use by organ procurement organizations (OPOs). The survey was posted for 5 weeks on the Association of OPOs Portal...
December 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27723449/selection-strategies-for-newly-registered-blood-donors-in-european-countries
#5
Ryanne W Lieshout-Krikke, Dragoslav Domanovic, Wim De Kort, Wolfgang Mayr, Giancarlo M Liumbruno, Simonetta Pupella, Johann Kurz, Folke Knutson, Sheila Maclennan, Gilles Folléa
BACKGROUND: Two selection strategies for newly-registered blood donors are available: a single-visit selection called the standard selection procedure (SSP), and a two-stage selection named pre-donation and donation screening (PDS). This study reviews the selection strategies for newly-registered donors currently applied in European countries. MATERIAL AND METHODS: We collected data on donor selection procedures, blood donation, laboratory screening and HIV, HCV and HBV positive donors/donations from 2010 to 2013 in 30 European countries by using questionnaires...
September 27, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27663561/pharmacists-guide-to-the-management-of-organ-donors-after-brain-death
#6
REVIEW
Catherine Korte, Jennifer L Garber, Jillian L Descourouez, Katelyn R Richards, Karen Hardinger
PURPOSE: This article reviews organ donor pathophysiology as it relates to medication use with the goal of maximizing the successful procurement and transplantation of donor organs. SUMMARY: The number of patients requiring organ transplantation continues to grow, yet organ donation rates remain flat, making it critical to appropriately manage each organ donor in order to ensure viability of all transplantable organs. The care given to one organ donor is tantamount to the care of several transplant recipients...
November 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27651939/current-status-and-problems-of-lung-transplantation-in-japan
#7
REVIEW
Hiroshi Date
Lung transplantation has been performed worldwide and recognized as an effective treatment for patients with various end-stage lung diseases. Shortage of lung donors is one of the main obstacles in most of the countries, especially in Japan. Every effort has been made to promote organ donation during the past 20 years. In 2010, Japanese transplant low was revised so that the family of the brain dead donors can make a decision for organ donation. Since then, the number of cadaveric lung donor has increased by 5-fold...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27598872/organ-protective-intensive-care-in-organ-donors
#8
Klaus Hahnenkamp, Klaus Böhler, Heiner Wolters, Karsten Wiebe, Dietmar Schneider, Hartmut H-J Schmidt
BACKGROUND: The ascertainment of brain death (the irreversible, total loss of brain function) gives the physician the opportunity to limit or stop further treatment. Alternatively, if the brain-dead individual is an organ donor, the mode of treatment can be changed from patient-centered to donationcentered. Consensus-derived recommendations for the organ-protective treatment of brain-dead organ donors are not yet available in Germany. METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed, and on the authors' clinical experience...
August 22, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27571572/influence-of-antithymocyte-globulin-treatment-of-brain-dead-organ-donor-on-inflammatory-response-in-cardiac-grafts-an-experimental-study-in-mice
#9
Jamila Kremer, Gabriela K Muschitz, Klaus Aumayr, Philipp Moser, Gabor Szabo, Alexander Weymann, Andreas Zuckermann, Bruno K Podesser
The expression of proinflammatory cytokines in donor hearts after antithymocyte globulin (ATG) treatment given prior to organ removal was evaluated to analyze changes in inflammatory response. Adult female OF-1 mice were randomized into brain death (BD) groups (BD Control, BD ATG) with or without treatment, and Controls (Control, ATG). BD induction was performed through gradual inflation of an intracranial positioned balloon catheter. At the end of a 6-h observation period, ATG (1 mg/kg BW) was given intravenously...
August 29, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27565252/management-of-the-risks-for-inherited-disease-in-donor-conceived-offspring
#10
Lauren Isley, Rena E Falk, Jaime Shamonki, Charles A Sims, Pamela Callum
OBJECTIVE: To illustrate the burden of inherited disease on donor-conceived offspring based on mode of inheritance and to provide guidance on methods of risk reduction. DESIGN: An 8.5-year retrospective review of outcome reports and donor management to summarize medical risks to donor-conceived offspring that presented after the sperm donors were qualified for participation in the donor program. SETTING: Not applicable. PATIENT(S): None...
August 23, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27555674/the-development-and-current-status-of-intensive-care-unit-management-of-prospective-organ-donors
#11
REVIEW
Margaret Kathleen Menzel Ellis, Mitchell Brett Sally, Darren Malinoski
INTRODUCTION: Despite continuous advances in transplant medicine, there is a persistent worldwide shortage of organs available for donation. There is a growing body of research that supports that optimal management of deceased organ donors in Intensive Care Unit can substantially increase the availability of organs for transplant and improve outcomes in transplant recipients. METHODS: A systematic literature review was performed, comprising a comprehensive search of the PubMed database for relevant terms, as well as individual assessment of references included in large original investigations, and comprehensive society guidelines...
July 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/27543840/prediction-prevention-and-management-of-delayed-graft-function-where-are-we-now
#12
Björn Nashan, Mario Abbud-Filho, Franco Citterio
Delayed graft function (DGF) remains a major barrier to improved outcomes after kidney transplantation. High-risk transplant recipients can be identified, but no definitive prediction model exists. Novel biomarkers to predict DGF in the first hours post-transplant, such as neutrophil gelatinase-associated lipocalin (NGAL), are under investigation. Donor management to minimize the profound physiological consequences of brain death is highly complex. A hormonal resuscitation package to manage the catecholamine "storm" that follows brain death is recommended...
October 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27513599/survey-of-u-s-organ-procurement-organizations-regarding-pediatric-organ-donor-management
#13
Robert S Ream, Eric S Armbrecht
OBJECTIVE: To describe the current practice of pediatric organ donor management in the United States for donors declared dead based upon neurologic criteria. The study directs particular attention to how pediatric donors are defined, the use of donor management guidelines, the use of donor management goals, and the involvement of pediatric critical care or transplantation expertise. DESIGN: Cross-sectional observational study using a web-based survey and follow-up telephone interview with respondents from U...
October 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27490874/advances-in-organ-preservation-for-transplantation
#14
Ahmer M Hameed, Wayne J Hawthorne, Henry C Pleass
Organ transplantation provides the best available therapy for a myriad of medical conditions, including end-stage renal disease, hepatic failure and type I diabetes mellitus. The current clinical reality is, however, that there is a significant shortage of organs available for transplantation with respect to the number of patients on organ waiting lists. As such, methods to increase organ supply have been instituted, including improved donor management, organ procurement and preservation strategies, living organ donation, transplantation education and the increased utilization of donation after circulatory death and expanded criteria donors...
August 4, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27460305/the-organ-preservation-and-enhancement-of-donation-success-ratio-effect-of-extracorporeal-membrane-oxygenation-in-circulatory-unstable-brain-death-donor
#15
Xiaoli Fan, Zhiquan Chen, David Nasralla, Xianpeng Zeng, Jing Yang, Shaojun Ye, Yi Zhang, Guizhu Peng, Yanfeng Wang, Qifa Ye
Between 2010 and 2013, we recorded 66 cases of failed organ donation after brain death (DBD) due to the excessive use of the vasoactive drugs resulting in impaired hepatic and/or renal function. To investigate the effect of extracorporeal membrane oxygenation (ECMO) in donor management, ECMO was used to provide support for DBD donors with circulatory and/or respiratory failure from 2013 to 2015. A retrospective cohort study between circulatory non-stable DBD with vasoactive drugs (DBD-drug) and circulatory non-stable DBD with ECMO (DBD-ECMO) was designed to compare the transplant outcomes...
October 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27369862/toll-like-receptor-1-variation-increases-the-risk-of-transplant-related-mortality-in-hematologic-malignancies
#16
Kaori Uchino, Shohei Mizuno, Motonori Mizutani, Tomohiro Horio, Ichiro Hanamura, J Luis Espinoza, Keitaro Matsuo, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Noriko Doki, Koichi Miyamura, Takehiko Mori Takehiko Mori, Akiyoshi Takami
Toll-like receptor 1 (TLR1) genetic variant (rs5743551, -7202A>G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM)...
September 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27339300/serum-ferritin-in-plateletpheresis-and-whole-blood-donors
#17
Frances Duggan, Kathleen O'Sullivan, Joan P Power, Michael Healy, William G Murphy
BACKGROUND AND OBJECTIVES: We performed a prospective analysis of iron status in plateletpheresis donors, using whole blood donors as a control group, to assess the haematinic effects of regular anti-coagulated extracorporeal circulation and platelet collection. MATERIALS AND METHODS: Ferritin levels were measured in samples from 31 regular male plateletpheresis donors and from 14 first time male whole blood donors, immediately before and immediately after donation, and immediately before the next donation...
August 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27312683/lung-ultrasound-utility-in-the-management-of-the-neurologically-deceased-organ-donor
#18
Daniel J Lebovitz, Matthew Tabbut, Samir Q Latifi, Lynn Dezelon, Robert Jones
CONTEXT: Lung transplantation is limited by donor lung availability with ∼20% of deceased donor lungs transplanted. Diagnostic testing identifying pulmonary derangements guide donor management strategies to maximize lung transplantation. Lung ultrasound (LUS) identifies pathology in critically ill patients equivalent or superior to chest radiograph (CXR) or computed tomography (CT) scans. No published studies have reported on LUS in neurologically deceased donors (DNDDs). OBJECTIVE: We evaluated LUS in identifying abnormal lung pathology in DNDDs and related these findings to the standard approach...
September 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27193126/slow-induction-of-brain-death-leads-to-decreased-renal-function-and-increased-hepatic-apoptosis-in-rats
#19
Rolando A Rebolledo, Dane Hoeksma, Christina M V Hottenrott, Yves J L Bodar, Petra J Ottens, Janneka Wiersema-Buist, Henri G D Leuvenink
BACKGROUND: Donor brain death (BD) is an independent risk factor for graft survival in recipients. While in some patients BD results from a fast increase in intracranial pressure, usually associated with trauma, in others, intracranial pressure increases more slowly. The speed of intracranial pressure increase may be a possible risk factor for renal and hepatic graft dysfunction. This study aims to assess the effect of speed of BD induction on renal and hepatic injury markers. METHODS: BD induction was performed in 64 mechanically ventilated male Fisher rats by inflating a 4...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27184253/a-prospective-evaluation-of-chronic-babesia-microti-infection-in-seroreactive-blood-donors
#20
Evan M Bloch, Andrew E Levin, Phillip C Williamson, Sherri Cyrus, Beth H Shaz, Debra Kessler, Jed Gorlin, Roberta Bruhn, Tzong-Hae Lee, Leilani Montalvo, Hany Kamel, Michael P Busch
BACKGROUND: Babesia microti is the foremost infectious risk to the US blood supply for which a Food and Drug Administration (FDA)-licensed test is unavailable for donation screening. Characterization of the antibody response to B. microti and correlation with parasitemia is necessary to guide screening and donor management policies. STUDY DESIGN AND METHODS: During an FDA licensure trial, blood donors were prospectively screened (July-November 2013) using a B. microti-specific antibody enzyme immunoassay (EIA, Immunetics) in highly endemic (New York [NY]; n = 13,688), moderately endemic (Minnesota [MN]; n = 4583), and nonendemic (New Mexico [NM]; n = 8451) regions...
July 2016: Transfusion
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