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https://www.readbyqxmd.com/read/28318674/organ-donor-management-eight-common-recommendations-and-actions-that-deserve-reflection
#1
C Chamorro-Jambrina, M R Muñoz-Ramírez, J L Martínez-Melgar, M S Pérez-Cornejo
Despite major advances in our understanding of the physiopathology of brain death (BD), there are important controversies as to which protocol is the most appropriate for organ donor management. Many recent reviews on this subject offer recommendations that are sometimes contradictory and in some cases are not applied to other critically ill patients. This article offers a review of the publications (many of them recent) with an impact upon these controversial measures and which can help to confirm, refute or open new areas of research into the most appropriate measures for the management of organ donors in BD, and which should contribute to discard certain established recommendations based on preconceived ideas, that lead to actions lacking a physiopathological basis...
March 16, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28260484/impact-of-a-full-time-donor-management-protocol-on-donors-liver-biopsy-findings-progress-to-date
#2
Meysam Mojtabaee, Alireza Shamsaeefar, Siavash Gholami, Mojtaba Mohsenzadeh, Farahnaz Sadegh Beigee
OBJECTIVES: This study investigated a fixed coordinator-directed donor management strategy's impact on donated liver quality, as determined by definitive biopsy results. MATERIALS AND METHODS: We collected donated liver biopsy results from donations both before and after implementing a fixed coordinator-directed donor management strategy. This strategy involved full-time attendance by a donor coordinator and continued resuscitation of brain-dead donors. All donations took place in a single organ procurement unit...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260449/living-kidney-donor-cancellation-at-king-hussein-medical-center
#3
Katibh Al-Rabadi, Reham Issa Almardini, Mysoon Hajeer, Mahmood Hendawi, Aiham Hadad
OBJECTIVES: Living-related kidney donation is the main source of renal grafts in Jordan, since kidneys from deceased donors are scarce. Although the Jordanian community accepts the idea of kidney donation to family members, not all potential donors manage to complete the required psychologic and medical evaluations. We review the causes of kidney-donation cancellation and suggest options to increase the number of available organs. MATERIALS AND METHODS: We performed a retrospective chart review of all potential living-related kidney donors at King Hussein Medical Center between January 2008 and June 2016...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28240643/heart-allograft-preservation-an-arduous-journey-from-the-donor-to-the-recipient
#4
Michiel Erasmus, Arne Neyrink, Mario Sabatino, Luciano Potena
PURPOSE OF REVIEW: The discrepancy between needs and availability of organs for heart transplantation may be partially reduced by improving the utilization of organs currently deemed unsuitable. Strategies to achieve this goal need optimization of the entire process of organ procurement, transportation, and functional recovery after transplant. RECENT FINDINGS: In the latest years, several studies reported improvements in organ utilization after appropriate donor management, and management of heart transportation is approaching a new era...
February 24, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28220496/the-donor-of-the-future-project-first-results-and-further-research-domains
#5
L M Sundermann, W L de Kort, S Boenigk
BACKGROUND: The Alliance of Blood Operators initiated a project labelled 'Donor of the Future'. This study gives an overview of the project results, in particular with regard to country differences. STUDY DESIGN AND METHODS: A large survey (N = 7663) among blood donors in six countries was conducted to analyse the effects of five global areas of change: (1) demographic change; (2) technological developments; (3) health innovations; (4) public, behavioural and attitudinal aspects; and (5) political, economic and environmental issues...
February 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28174393/-lung-transplantation-allograft-and-xenograft
#6
Hiroshi Date
Lung transplantation has been performed worldwide and recognized as an effective treatment for patients with various end-stage lung diseases. Shortage of lung donors is one of the main obstacles. Lung transplantation in the use of donation after cardiac death has now been increasingly performed in Europe and USA with promising results. However, controlled death is not permitted in Japan making it difficult to accept this strategy. Use of marginal donors is one of the strategies. In Japan, the rate of lung usage is now well over 60% owing to careful donor management by medical consultants and aggressive use of marginal donors...
January 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28108262/deceased-organ-donor-management-does-hospital-volume-matter
#7
Madhukar S Patel, Jahan Mohebali, Mitchell Sally, Tahnee Groat, Parsia A Vagefi, David C Chang, Darren J Malinoski
BACKGROUND: Identification of strategies to improve organ donor use remains imperative. Despite the association between hospital volume and outcomes for many common disease processes, there have been no studies that assess the impact of organ donor hospital volume on organ yield. STUDY DESIGN: A prospective observational study of all deceased organ donors managed by 10 organ procurement organizations across United Network for Organ Sharing regions 4, 5, and 6 was conducted from February 2012 to June 2015...
March 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28059967/actual-risk-of-using-very-aged-donors-for-unselected-liver-transplant-candidates-a-european-single-center-experience-in-the-meld-era
#8
Valentina Rosa Bertuzzo, Matteo Cescon, Federica Odaldi, Marco Di Laudo, Alessandro Cucchetti, Matteo Ravaioli, Massimo Del Gaudio, Giorgio Ercolani, Antonietta D'Errico, Antonio Daniele Pinna
OBJECTIVE: To evaluate the whole experience of liver transplantation (LT) with donors ≥70 years in a single center not applying specific donor/recipient matching criteria. BACKGROUND: LT with very old donors has historically been associated with poorer outcomes. With the increasing average donor age and the advent of Model for End-stage Liver Diseases (MELD) score-based allocation criteria, an optimal donor/recipient matching is often unsuitable. METHODS: Outcomes of all types of LTs were compared according to 4 study groups: patients transplanted between 1998 and 2003 with donors <70 (group 1, n = 396) or ≥70 years (group 2, n = 88); patients transplanted between 2004 and 2010 with donors <70 (group 3, n = 409), or ≥70 years (group 4, n = 190)...
February 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28024551/end-of-life-issues-in-cardiac-critical-care-the-option-of-organ-donation
#9
REVIEW
Karim Serri, Pierre Marsolais
Despite important advances in the care of postcardiac arrest patients, severe brain injury remains one of the major causes of death in the cardiac intensive care unit. Neurological prognostication after cardiac arrest has evolved significantly since the introduction of therapeutic hypothermia. It now relies on a multimodal approach and a minimal observation period of 72 hours is usually advocated. However, when brain injury is severe and the prognosis considered dismal, patients become eligible for organ donation...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27873446/the-first-2-years-of-activity-of-a-specialized-organ-procurement-center-report-of-an-innovative-approach-to-improve-organ-donation
#10
P Marsolais, P Durand, E Charbonney, K Serri, A-M Lagacé, F Bernard, M Albert
The number of patients requiring organ transplants continues to outgrow the number of organs donated each year. In an attempt to improve the organ donation process and increase the number of organs available, we created a specialized multidisciplinary team within a specialized organ procurement center (OPC) with dedicated intensive care unit (ICU) beds and operating rooms. The OPC was staffed with ICU nurses, operating room nurses, organ donor management ICU physicians, and multidisciplinary staff. All organ donors within a designated geographic area were transferred to and managed within the OPC...
November 22, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27739151/feasibility-of-routine-ferritin-testing-for-donor-management-validation-of-delayed-processing-and-demonstration-of-within-donor-reproducibility-over-time
#11
Mars Stone, Donald Brambilla, Karla Murcia, Melanie Dimapasoc, Sherri Cyrus, Ritchard G Cable, Joseph E Kiss, Michael P Busch
BACKGROUND: Understanding the effect of delayed processing of whole blood on plasma ferritin will inform the feasibility of both routine ferritin testing in donors and clinical research study design. STUDY DESIGN AND METHODS: Whole blood tubes drawn from 16 donors were held at 4°C and centrifuged at 24-hour intervals to assess plasma ferritin concentration up to 5 days after draw. Intraindividual variation over time was measured in 21 healthy donors in blood samples collected weekly for 4 weeks and then at 12 weeks...
October 2016: Transfusion
https://www.readbyqxmd.com/read/27727092/-deceased-donation-in-renal-transplantation
#12
R Thuret, F Kleinclauss, N Terrier, M O Timsit
OBJECTIVES: To review epidemiologic data's and medical results of deceased donation in renal transplantation. MATERIAL AND METHODS: Relevant publications were identified through Medline (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) database using the following keywords, alone or in association, "brain death; cardiac arrest; deceased donation; organ procurement; transplantation". Articles were selected according to methods, language of publication and relevance...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27726211/thyroid-hormone-use-during-cardiac-transplant-organ-procurement
#13
Lauren B Cooper, Carmelo A Milano, Melissa Williams, Wendy Swafford, Donna Croezen, Adrian B Van Bakel, Joseph G Rogers, Chetan B Patel
BACKGROUND: Acute hypothyroidism after brain death results in hemodynamic impairments that limit availability of donor hearts. Thyroid hormone infusions can halt that process and lead to increased utilization of donor organs, but prolonged use of thyroid replacement has not been well studied. METHODS: We developed a 15-question survey regarding policies, procedures, and reporting of thyroid hormone use by organ procurement organizations (OPOs). The survey was posted for 5 weeks on the Association of OPOs Portal...
December 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27723449/selection-strategies-for-newly-registered-blood-donors-in-european-countries
#14
Ryanne W Lieshout-Krikke, Dragoslav Domanovic, Wim De Kort, Wolfgang Mayr, Giancarlo M Liumbruno, Simonetta Pupella, Johann Kurz, Folke Knutson, Sheila Maclennan, Gilles Folléa
BACKGROUND: Two selection strategies for newly-registered blood donors are available: a single-visit selection called the standard selection procedure (SSP), and a two-stage selection named pre-donation and donation screening (PDS). This study reviews the selection strategies for newly-registered donors currently applied in European countries. MATERIAL AND METHODS: We collected data on donor selection procedures, blood donation, laboratory screening and HIV, HCV and HBV positive donors/donations from 2010 to 2013 in 30 European countries by using questionnaires...
September 27, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27663561/pharmacists-guide-to-the-management-of-organ-donors-after-brain-death
#15
REVIEW
Catherine Korte, Jennifer L Garber, Jillian L Descourouez, Katelyn R Richards, Karen Hardinger
PURPOSE: This article reviews organ donor pathophysiology as it relates to medication use with the goal of maximizing the successful procurement and transplantation of donor organs. SUMMARY: The number of patients requiring organ transplantation continues to grow, yet organ donation rates remain flat, making it critical to appropriately manage each organ donor in order to ensure viability of all transplantable organs. The care given to one organ donor is tantamount to the care of several transplant recipients...
November 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27651939/current-status-and-problems-of-lung-transplantation-in-japan
#16
REVIEW
Hiroshi Date
Lung transplantation has been performed worldwide and recognized as an effective treatment for patients with various end-stage lung diseases. Shortage of lung donors is one of the main obstacles in most of the countries, especially in Japan. Every effort has been made to promote organ donation during the past 20 years. In 2010, Japanese transplant low was revised so that the family of the brain dead donors can make a decision for organ donation. Since then, the number of cadaveric lung donor has increased by 5-fold...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27598872/organ-protective-intensive-care-in-organ-donors
#17
Klaus Hahnenkamp, Klaus Böhler, Heiner Wolters, Karsten Wiebe, Dietmar Schneider, Hartmut H-J Schmidt
BACKGROUND: The ascertainment of brain death (the irreversible, total loss of brain function) gives the physician the opportunity to limit or stop further treatment. Alternatively, if the brain-dead individual is an organ donor, the mode of treatment can be changed from patient-centered to donationcentered. Consensus-derived recommendations for the organ-protective treatment of brain-dead organ donors are not yet available in Germany. METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed, and on the authors' clinical experience...
August 22, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27571572/influence-of-antithymocyte-globulin-treatment-of-brain-dead-organ-donor-on-inflammatory-response-in-cardiac-grafts-an-experimental-study-in-mice
#18
Jamila Kremer, Gabriela K Muschitz, Klaus Aumayr, Philipp Moser, Gabor Szabo, Alexander Weymann, Andreas Zuckermann, Bruno K Podesser
The expression of proinflammatory cytokines in donor hearts after antithymocyte globulin (ATG) treatment given prior to organ removal was evaluated to analyze changes in inflammatory response. Adult female OF-1 mice were randomized into brain death (BD) groups (BD Control, BD ATG) with or without treatment, and Controls (Control, ATG). BD induction was performed through gradual inflation of an intracranial positioned balloon catheter. At the end of a 6-h observation period, ATG (1 mg/kg BW) was given intravenously...
December 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27565252/management-of-the-risks-for-inherited-disease-in-donor-conceived-offspring
#19
Lauren Isley, Rena E Falk, Jaime Shamonki, Charles A Sims, Pamela Callum
OBJECTIVE: To illustrate the burden of inherited disease on donor-conceived offspring based on mode of inheritance and to provide guidance on methods of risk reduction. DESIGN: An 8.5-year retrospective review of outcome reports and donor management to summarize medical risks to donor-conceived offspring that presented after the sperm donors were qualified for participation in the donor program. SETTING: Not applicable. PATIENT(S): None...
November 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27555674/the-development-and-current-status-of-intensive-care-unit-management-of-prospective-organ-donors
#20
REVIEW
Margaret Kathleen Menzel Ellis, Mitchell Brett Sally, Darren Malinoski
INTRODUCTION: Despite continuous advances in transplant medicine, there is a persistent worldwide shortage of organs available for donation. There is a growing body of research that supports that optimal management of deceased organ donors in Intensive Care Unit can substantially increase the availability of organs for transplant and improve outcomes in transplant recipients. METHODS: A systematic literature review was performed, comprising a comprehensive search of the PubMed database for relevant terms, as well as individual assessment of references included in large original investigations, and comprehensive society guidelines...
July 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
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