keyword
https://read.qxmd.com/read/38536193/-complications-of-intravesical-bcg-therapy
#1
JOURNAL ARTICLE
Aresh Farokhnia, Silvana K Rampini, Micha Gundelfinger
BCG instillations are considered to be the standard of care therapy for superficial urothelial bladder carcinoma. Although serious adverse events are uncommon, the presence of high fever for at least two days in conjunction with systemic and/or local organ manifestations (except for urogenital symptoms), with the exclusion of other causes, suffice for the diagnosis of a disseminated BCG infection. Microbiologic detection of the pathogen is not necessary for diagnosis, as the detection of granuloma is more often successful and sufficient...
February 2024: Praxis
https://read.qxmd.com/read/38536192/-bcg-instillation-sepsis-in-bladder-carcinoma
#2
EDITORIAL
Hubert John
No abstract text is available yet for this article.
February 2024: Praxis
https://read.qxmd.com/read/38535546/diagnosis-and-management-of-infections-in-patients-with-mendelian-susceptibility-to-mycobacterial-disease
#3
REVIEW
Aparna Dalvi, Umair Ahmed Bargir, Gita Natraj, Ira Shah, Manisha Madkaikar
The diagnosis and treatment of patients with mendelian susceptibility to mycobacterial disease (MSMD) pose consistent challenges due to the diverse infection spectrum observed in this population. Common clinical manifestations include Bacillus Calmette-Guérin vaccine (BCG) complications in countries where routine BCG vaccination is practiced, while in non-BCG-vaccinating countries, Non-Tuberculous Mycobacteria (NTM) is prevalent. In tuberculosis-endemic regions, Mycobacterium tuberculosis (MTB) has a high prevalence, along with other intracellular organisms...
February 25, 2024: Pathogens
https://read.qxmd.com/read/38533423/delayed-diagnosis-of-mycobacteri-um-bovis-bacillus-calmette-gu%C3%A3-rin-periprosthetic-joint-infection-following-total-knee-arthroplasty
#4
Christopher E Pelt, Salika Shakir, Michael J Cahill, Jakrapun Pupaibool, Barbara C Cahill
Periprosthetic joint infection (PJI) can present challenges in diagnosis and treatment, particularly in the setting of atypical causative organisms such as fungi and mycobacteria. Herein, we present a case and provide a review of the diagnosis and treatment of an unusual PJI caused by bacillus Calmette-Guérin, administered during the treatment of bladder cancer 3 years prior to total knee arthroplasty and subsequent PJI. Although the patient's history of bladder cancer was known, neither his Bacillus Calmette-Guérin treatment nor its potential for distant site spread that could lead to PJI were appreciated, leading to a prolonged diagnostic evaluation and treatment course...
June 2024: Arthroplasty Today
https://read.qxmd.com/read/38532491/non-specific-effects-of-inactivated-mycobacterium-bovis-oral-and-parenteral-treatment-in-a-rabbit-scabies-model
#5
JOURNAL ARTICLE
Rosa Casais, Natalia Iglesias, Iker A Sevilla, Joseba M Garrido, Ana Balseiro, Mercedes Dominguez, Ramon A Juste
Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type of immune mechanism that triggered by a pathogen, protects against others. Killed vaccines have been considered not to be effective. However, field efficacy of a commercial vaccine against paratuberculosis, as well as of a recently developed M. bovis heat-inactivated vaccine (HIMB) prompted to test whether it could also induce TRAIM. To this, we used a sarcoptic mange rabbit model...
March 26, 2024: Veterinary Research
https://read.qxmd.com/read/38529287/antibody-mediated-depletion-of-select-leukocyte-subsets-in-blood-and-tissue-of-nonhuman-primates
#6
JOURNAL ARTICLE
Matthew S Sutton, Allison N Bucsan, Chelsea C Lehman, Megha Kamath, Supriya Pokkali, Diogo M Magnani, Robert Seder, Patricia A Darrah, Mario Roederer
Understanding the immunological control of pathogens requires a detailed evaluation of the mechanistic contributions of individual cell types within the immune system. While knockout mouse models that lack certain cell types have been used to help define the role of those cells, the biological and physiological characteristics of mice do not necessarily recapitulate that of a human. To overcome some of these differences, studies often look towards nonhuman primates (NHPs) due to their close phylogenetic relationship to humans...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38519296/a-prognostic-index-derived-from-lasso-selected-preoperative-inflammation-and-nutritional-markers-for-non-muscle-invasive-bladder-cancer
#7
JOURNAL ARTICLE
Dengxiong Li, Ruicheng Wu, Jie Wang, Junjiang Ye, Qingxin Yu, Dechao Feng, Ping Han
BACKGROUND: There is an urgent need to identify a robust predictor for BCG response in patients with non-muscle-invasive bladder cancer (NMIBC). We aimed to employ the Lasso regression model for the selection and construction of an index (BCGI) utilizing inflammation and nutrition indicators to predict the response to BCG therapy. METHODS: After acquiring the ethics approval, we searched the electric medical records in our institution and performed data screening...
February 29, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38516388/current-status-and-future-prospects-of-echinococcus-multilocularis-vaccine-candidates-a-systematic-review
#8
REVIEW
Maryam Hataminejad, Davood Anvari, Nahid Khaleghi, Tooran Nayeri, Reza Shirazinia, Seyyed Ali Shariatzadeh, Seyed Abdollah Hosseini, Abolghasem Siyadatpanah, Shirzad Gholami
The larval stages of Echinococcus multilocularis ( E. multilocularis ) are what cause the zoonotic disease known as alveolar echinococcosis (AE). Identifying the antigens that trigger immune responses during infection is extremely important for the development of vaccines against Echinococcus infections. Several studies conducted in recent decades have described the specific traits of the protective antigens found in E. multilocularis and their role in immunizing different animal hosts. The objective of the current systematic review was to summarize the findings of relevant literature on this topic and unravel the most effective vaccine candidate antigens for future research...
June 2024: Veterinary and Animal Science
https://read.qxmd.com/read/38516176/necrotizing-granulomatous-epididymo-orchitis-post-intravesical-bcg-administration-after-brachytherapy-for-prostate-cancer
#9
Jay K Jhaveri, Aaron Dahmen, Alon Lazarovich, David Nusbaum, Quoc-Dien Trinh, Nilesh Gupta, Piyush K Agarwal
Urothelial carcinoma of the bladder remains a challenging disease to treat. Intravesical instillation of BCG has demonstrated tremendous efficacy in preventing recurrence. BCG related necrotizing granulomatous epididymo-orchitis is rare and has not been previously linked to brachytherapy for adenocarcinoma of the prostate. We hypothesize that prior brachytherapy has a deleterious effect on the verumontanum that can result in retrograde transmission of BCG particles leading to granulomatous epididymo-orchitis...
May 2024: Urology Case Reports
https://read.qxmd.com/read/38515465/maternal-and-child-health-indicators-in-primary-healthcare-facilities-findings-in-a-health-systems-quasi-experimental-study-in-western-kenya
#10
JOURNAL ARTICLE
Fabian Esamai, Ann Mwangi, Mabel Nangami, John Tabu, David Ayuku, Edwin Were
BACKGROUND AND PURPOSE: Maternal and infant mortality are higher in low-income than in high-income countries due to weak health systems. The objective of this study was to improve access, utilization and quality of Maternal and Child Health care through a predesigned Enhanced Health Care System (EHC) that embodies the World Health Organization (WHO) pillars of the health system. DESIGN AND METHODOLOGY: This study was conducted in two dispensaries in the Counties of Busia and Bungoma in Kenya as intervention sites and in four control clusters in Kakamega, Uasin Gishu, Trans Nzoia and Elgeyo Marakwet Counties...
December 2023: Dialogues Health
https://read.qxmd.com/read/38512892/exploring-trends-and-determinants-of-basic-childhood-vaccination-coverage-empirical-evidence-over-41-years
#11
JOURNAL ARTICLE
Paloma Lanza-León, David Cantarero-Prieto, Marta Pascual-Sáez
Vaccination is widely considered to be one of the most important prevention measures as a health strategy. This paper examines trends in basic childhood vaccination coverage and which country and time-dependent determinants may have influenced childhood immunization rates (1-dose BCG, 1- and 3-dose DTP (diphtheria, tetanus, pertussis), 1-dose measles, and 3-dose polio) between 1980 and 2020 across 94 countries. We identify economic, inequality, demographic, health, education, labor market, environmental, and political stability factors of immunization...
2024: PloS One
https://read.qxmd.com/read/38512511/treatment-patterns-and-prognosis-in-patients-with-bacillus-calmette-gu%C3%A3-rin-exposed-high-risk-non-muscle-invasive-bladder-cancer-a-real-world-data-analysis
#12
JOURNAL ARTICLE
Nobutaka Nishimura, Makito Miyake, Kota Iida, Tatsuki Miyamoto, Ryotaro Tomida, Kazuyuki Numakura, Junichi Inokuchi, Takahiro Yoneyama, Eijiro Okajima, Shugo Yajima, Hitoshi Masuda, Naoki Terada, Rikiya Taoka, Takashi Kobayashi, Takahiro Kojima, Yoshiyuki Matsui, Naotaka Nishiyama, Hiroshi Kitamura, Hiroyuki Nishiyama, Kiyohide Fujimoto
PURPOSE: The International Bladder Cancer Group designated the subgroup that is resistant to Bacillus Calmette-Guérin (BCG) but does not meet the criteria for BCG-unresponsive NMIBC as "BCG-exposed high-risk NMIBC" to guide optimal trial design. We aimed to investigate the treatment patterns and prognoses of patients with BCG-exposed NMIBC. METHODS: We conducted a retrospective chart review of 3283 patients who received intravesical BCG therapy for NMIBC at 14 participating institutions between January 2000 and December 2019...
March 21, 2024: World Journal of Urology
https://read.qxmd.com/read/38508438/patient-characteristics-correlate-with-diagnostic-performance-of-photodynamic-diagnostic-assisted-transurethral-resection-of-bladder-tumors-a-retrospective-single-center-study
#13
JOURNAL ARTICLE
Shuhei Suzuki, Yoshiyuki Nagumo, Atsushi Ikeda, Kosuke Kojo, Satoshi Nitta, Ichiro Chihara, Masanobu Shiga, Takashi Kawahara, Shuya Kandori, Akio Hoshi, Hiromitsu Negoro, Bryan J Mathis, Hiroyuki Nishiyama
BACKGROUND: Identification of patient subclasses that correlate with the diagnostic performance of photodynamic diagnostic (PDD)-assisted transurethral resection of bladder tumors (TURBT) may improve outcomes. METHODS: Data were extracted from patients that underwent PDD-assisted TURBT at the University of Tsukuba Hospital between 2018-2023. Sensitivity and specificity were evaluated based on PDD findings (excluding WL findings) and pathology results. Cluster analysis using uniform manifold approximation and projection and k-means methods was performed, focusing on patients with malignant lesions...
March 18, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38508149/the-efficacy-and-safety-of-hyperthermia-intravesical-chemotherapy-in-the-treatment-non-muscle-invasive-bladder-cancer-a-meta-analysis
#14
Huanglin Duan, Zanxuan Deng, Junrong Zou, Guoxi Zhang, Xiaofeng Zou, Tianpeng Xie
Background:The current treatment of non-muscle-invasive bladder cancer is suboptimal. However, in recent years, hyperthermia intravesical chemotherapy has emerged as a more effective alternative to conventional bladder perfusion. This novel treatment approach appears to have a similar therapeutic effect as BCG perfusion. Objective: This study aims to evaluate the safety and effectiveness of hyperthermia intravesical chemotherapy compared to conventional bladder perfusion chemotherapy for non-muscle-invasive bladder cancer...
March 20, 2024: Urologia Internationalis
https://read.qxmd.com/read/38502387/the-applications-of-elispot-in-the-identification-and-treatment-of-various-forms-of-tuberculosis-and-in-the-cancer-immunotherapies
#15
JOURNAL ARTICLE
Hemant K Mishra
ELISpot (enzyme-linked immunospot) is a powerful immunological tool for the detection of cytokine-secreting cells at a single-cell resolution. It is widely used for the diagnosis of various infectious diseases, e.g., tuberculosis and sarcoidosis, and it is also widely used in cancer immunotherapy research. Its ability to distinguish between active and latent forms of tuberculosis makes it an extremely powerful tool for epidemiological studies and contact tracing. In addition to that, it is a very useful tool for the research and development of cancer immunotherapies...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38502039/patterns-of-treatment-of-high-risk-bcg-unresponsive-non-muscle-invasive-bladder-cancer-nmibc-patients-among-arab-urologists
#16
JOURNAL ARTICLE
Mohamad Moussa, Mohamad Abou Chakra, Neal D Shore, Athanasios Papatsoris, Yasser Farahat, Michael A O'Donnell
PURPOSE: To understand the treatment plans suggested for BCG-unresponsive non-muscle invasive disease (NMIBC) patients in the Arab countries and therapeutic decisions applied for BCG-naive patients during BCG shortage time. METHODS: A 10-minute online survey was distributed through the Arab Association of Urology (AAU) office to urologists in the Arab countries who treat patients with NMIBC. RESULTS: One hundred six urologists responded to the survey...
March 19, 2024: Archivio Italiano di Urologia, Andrologia
https://read.qxmd.com/read/38500576/effects-of-neonatal-bcg-japan-versus-bcg-russia-vaccination-on-overall-mortality-and-morbidity-randomized-controlled-trial-from-guinea-bissau-bcgstrain-ii
#17
Frederik Schaltz-Buchholzer, Sebastian Nielsen, Marcus Kjær Sørensen, Elise Brenno Stjernholm, Rebecca Alison Fabricius, Paulo Umbasse, Ivan Monteiro, Elsi Jose Carlos Cá, Peter Aaby, Christine Stabell Benn
BACKGROUND: Vaccination with the Danish strain of bacille Calmette-Guérin (BCG) has been associated with pronounced reductions in all-cause neonatal mortality and morbidity. Developing a skin reaction postvaccination is associated with markedly reduced mortality risk. It is unknown whether the beneficial nonspecific effects are maintained across different BCG strains. METHODS: This was an open-label randomized controlled trial in Guinea-Bissau, comparing BCG-Japan (n = 8754) versus BCG-Russia (n = 8752) for all-cause hospital admission risk by 6 weeks of age (primary outcome) and 6 months of age...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38495492/uncovering-microbial-composition-of-the-tissue-microenvironment-in-bladder-cancer-using-rna-sequencing-data
#18
JOURNAL ARTICLE
Ruiqian Yao, Bin Ai, Zeyi Wang, Bing Shen, Geng Xue, Dong Yu
Purpose: Bladder cancer (BC) is one of the top 10 common tumors in the world. It has been reported that microbiota can colonize tissues and play important roles in tumorigenesis and progression. However, the current understanding of microorganisms in the BC tissue microenvironment remains unclear. Methods: In this study, we integrated the RNA-seq data of 479 BC tissue samples from seven datasets combined with a range of bioinformatics tools to explore the landscape of microbiome in the BC tissue microenvironment...
2024: Journal of Cancer
https://read.qxmd.com/read/38495158/protective-role-of-bacillus-calmette-gu%C3%A3-rin-vaccine-in-alzheimer-s-disease-progression-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Tungki Pratama Umar, Nityanand Jain, Bella Stevanny, Binish Javed, Andyra Priandhana, Reynold Siburian, Andrejs Kostiks
UNLABELLED: Introduction: Alzheimer's disease (AD) represents a significant societal challenge, highlighting the need to explore effective prevention and treatment approaches. Recent literature has suggested that Bacillus Calmette-Guérin (BCG) vaccine may be a viable therapeutic option for immune disorders associated with AD due to its immunomodulatory properties and protection against various diseases. METHODS: This systematic review aimed to evaluate the association of BCG vaccine in the prevention of AD using six medical-scientific databases...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38491799/cost-effectiveness-analysis-of-different-treatment-modalities-in-bcg-unresponsive-nmibc
#20
JOURNAL ARTICLE
Constantin Rieger, Jörg Schlüchtermann, Enno Storz, Lucas Kastner, David Pfister, Axel Heidenreich
OBJECTIVE: Radical cystectomy (RC) is the standard of care (SOC) in BCG-unresponsive NMIBC and is associated with a significant health-related quality-of-life burden. Recently, promising results have been published on Gemcitabine/Docetaxel, Pembrolizumab, and Hyperthermic Intravesical Chemotherapy (HIVEC) as salvage therapy options trying to increase the rate of bladder preservation. Here, we performed a Cost-Effectiveness-Analysis of those treatment modalities. PATIENTS AND METHODS: We developed a Markov model from a payer's perspective drawing on clinical data of single-arm trials testing intravesical gemcitabine/docetaxel and pembrolizumab in BCG-unresponsive NMIBC, as well as clinical data from patients receiving hyperthermic intravesical chemotherapy HIVEC (n = 29) as intravesical salvage chemotherapy at our uro-oncological centre in Cologne...
March 16, 2024: BJU International
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