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JOURNAL ARTICLE
Lucas D Pedroza-Camacho, Paula A Ospina-Sánchez, Felipe A Romero-Perdomo, Nury G Infante-González, Diana M Paredes-Céspedes, Balkys Quevedo-Hidalgo, Viviana Gutiérrez-Romero, Claudia M Rivera-Hoyos, Aura M Pedroza-Rodríguez
UNLABELLED: During and after the pandemic caused by the SARS-CoV-2 virus, the use of personal care products and disinfectants increased in universities worldwide. Among these, quaternary ammonium-based products stand out; these compounds and their intermediates caused substantial changes in the chemical composition of the wastewater produced by these institutions. For this reason, improvements and environmentally sustainable biological alternatives were introduced in the existing treatment systems so that these institutions could continue their research and teaching activities...
May 2024: 3 Biotech
#22
JOURNAL ARTICLE
Nicole Conci, Andrea De Giglio, Francesca Sperandi, Barbara Melotti, Francesco Gelsomino
No abstract text is available yet for this article.
April 3, 2024: Chinese Clinical Oncology
#23
JOURNAL ARTICLE
Mikko S Venäläinen, Alexander Biehl, Milja Holstila, Laura Kuusalo, Laura L Elo
OBJECTIVES: Although deep learning has demonstrated substantial potential in automatic quantification of joint damage in rheumatoid arthritis (RA), evidence for detecting longitudinal changes at an individual patient level is lacking. Here, we introduce and externally validate our automated RA scoring algorithm (AuRA), and demonstrate its utility for monitoring radiographic progression in a real-world setting. METHODS: The algorithm, originally developed during the Rheumatoid Arthritis 2-Dialogue for Reverse Engineering Assessment and Methods (RA2-DREAM) challenge, was trained to predict expert-curated Sharp-van der Heijde total scores in hand and foot radiographs from two previous clinical studies (n = 367)...
April 10, 2024: Rheumatology
#24
JOURNAL ARTICLE
Yi-Chieh Chen, Han Wang, Jayawant N Mandrekar, Carrie E Robertson, Amaal J Starling, Fred M Cutrer, Chia-Chun Chiang
OBJECTIVE: To investigate factors affecting the efficacy and tolerability of verapamil for migraine prevention using individual pharmacogenomic phenotypes. BACKGROUND: Verapamil has a wide range of dosing in headache disorders without reliable tools to predict the optimal doses for an individual. METHODS: This is a retrospective chart review examining adults with existing pharmacogenomic reports at Mayo Clinic who had used verapamil for migraine...
April 9, 2024: Pharmacogenomics Journal
#25
JOURNAL ARTICLE
Claire Fayad, Kely Saad, Georges-Junior Kahwagi, Souheil Hallit, Darren Griffin, Rony Abou-Khalil, Elissar El-Hayek
INTRODUCTION: Juvenile Myoclonic Epilepsy (JME) is a prevalent form of epileptic disorder, specifically categorized within the realm of Genetic Generalized Epilepsy (GGE). Its hallmark features encompass unprovoked bilateral myoclonus and tonic-clonic seizures that manifest during adolescence. While most JME patients respond favorably to anti-seizure medication (ASM), a subset experiences refractory JME, a condition where seizures persist despite rigorous ASM treatment, often termed "Drug-Resistant Epilepsy" (DRE)...
2024: PloS One
#26
REVIEW
Justyna Chojdak-Łukasiewicz, Edyta Dziadkowiak
Visual snow syndrome (VSS) is a rarely diagnosed neurological phenomenon. It is a visual disorder characterised by the presence of numerous white, black, or translucent dots in the visual field, resembling the 'snow' of an analogue TV set experiencing reception interference. According to The International Classification of Headache Disorders, 3rd edition, visual snow is defined as a pattern of continuous small dots across the visual field lasting >3 months and accompanied by at least two of the following four additional symptoms: palinopsia, increased entoptic phenomena, photophobia, and nyctalopia...
February 28, 2024: Journal of Clinical Medicine
#27
JOURNAL ARTICLE
Alessandro Cecconello, Aura Cencini, Graziano Rilievo, Federica Tonolo, Lucio Litti, Fabio Vianello, Itamar Willner, Massimiliano Magro
DNA is an ideal template for the design of nanoarchitectures with molecular-like features. Here, we present an optimized assembly strategy for the concatenation of DNA quasi-rings into long scaffolds. Ionic strength, which played a major role during self-assembly, produced the expected high quality only at 15 mM MgCl2 . Atomic force microscopy (AFM) characterization showed several micrometer long tubular structures that were used as templates for the positioning of plasmonic nanoparticles (NPs) along a three-dimensional helical path using DNA tethers...
April 8, 2024: Nano Letters
#28
Kathleen Mullan Harris, Brandt Levitt, Lauren Gaydosh, Chantel Martin, Jess M Meyer, Aura Ankita Mishra, Audrey L Kelly, Allison E Aiello
IMPORTANCE: Epigenetic clocks represent molecular evidence of disease risk and aging processes and have been used to identify how social and lifestyle characteristics are associated with accelerated biological aging. However, most of this research is based on older adult samples who already have measurable chronic disease. OBJECTIVE: To investigate whether and how sociodemographic and lifestyle characteristics are related to biological aging in a younger adult sample across a wide array of epigenetic clock measures...
March 28, 2024: bioRxiv
#29
JOURNAL ARTICLE
Juniorcaius Ikejezie, Alessandro Miglietta, Ingrid Hammermeister Nezu, Sandra Adele, Melissa M Higdon, Daniel Feikin, Harsh Lata, Samuel Mesfin, Friday Idoko, Kazuki Shimizu, Ayse Acma, Samuel Moro, Homa Attar Cohen, Mary Anissa Sinnathamby, James Richard Otieno, Yosef Temre, Brian Ngongheh Ajong, Bernadette Basuta Mirembe, Tondri Noe Guinko, Vaishali Sodagar, Craig Schultz, Joao Muianga, Stéphane De Barros, Aura Rocio Escobar Corado Waeber, Yeowon Jin, Anahi Rico Chinchilla, Yurie Izawa, Shagun Khare, Marcia Poole, Nyka Alexander, Silviu Ciobanu, Tshewang Dorji, Mahmoud Hassan, Masaya Kato, Tamano Matsui, Opeayo Ogundiran, Richard G Pebody, Manilay Phengxay, Ana Riviere-Cinnamond, Blanche Johanna Greene-Cramer, Emilie Peron, Brett Nicholas Archer, Lorenzo Subissi, Zyleen Alnashir Kassamali, Adedoyin Awofisayo-Okuyelu, Olivier le Polain de Waroux, Esther Hamblion, Boris Igor Pavlin, Oliver Morgan, Ibrahima Socé Fall, Maria D Van Kerkhove, Abdi Mahamud
On 31 December 2019, the Municipal Health Commission of Wuhan, China, reported a cluster of atypical pneumonia cases. On 5 January 2020, the WHO publicly released a Disease Outbreak News (DON) report, providing information about the pneumonia cases, implemented response interventions, and WHO's risk assessment and advice on public health and social measures. Following 9 additional DON reports and 209 daily situation reports, on 17 August 2020, WHO published the first edition of the COVID-19 Weekly Epidemiological Update (WEU)...
April 4, 2024: BMJ Global Health
#30
JOURNAL ARTICLE
Mohamed Atfy Abd ElMotaleb, Amr Ragab El-Beialy, Fouad Aly El-Sharaby, Amr Emad ElDakroury, Ahmed Abdelsalam Eid
To investigate the effectiveness of AcceleDent Aura vibrating device on the rate of canine retraction. Thirty-two patients requiring extraction of upper first premolars and canine retraction were randomly allocated with a 1:1 ratio into either no-appliance group or the AcceleDent Aura appliance group. Canine retraction was done applying 150gm of retraction force using NiTi coil springs on 16 × 22 stainless steel archwires. The duration of the study was 4 months. Models were collected and digitized directly after extraction of upper first premolars and at monthly intervals during canine retraction for recording the monthly as well as the total distance moved by the canine...
April 4, 2024: Scientific Reports
#31
JOURNAL ARTICLE
Pathtamawadee Nuamduang, Rafael Auras, Charinee Winotapun, Bongkot Hararak, Wanwitoo Wanmolee, Pattarin Leelaphiwat
Sustainable poly(butylene succinate) (PBS) films incorporating lignin nanoparticles (LN) and trans-cinnamaldehyde (CN) have been developed to preserve mango freshness and provide food safety. PBS/LN, PBS/CN, and PBS/LN/CN composite films were produced by blown film melt extrusion. This study investigated the effect of CN-LN on the CN remaining content, thermal, mechanical, and barrier properties, diffusion coefficient, and antifungal activity of PBS films both in vitro and in vivo. Results showed that LN in the PBS/LN/CN composite film contained more CN than in the PBS/CN film...
March 31, 2024: International Journal of Biological Macromolecules
#32
Eugine Lee, Zeda Zhang, Chi-Chao Chen, Danielle Choi, Aura C Agudelo Rivera, Eliot Linton, Yu-Jui Ho, Jillian Love, Justin LaClair, John Wongvipat, Charles L Sawyers
There is optimism that cancer drug resistance can be addressed through appropriate combination therapy, but success requires understanding the growing complexity of resistance mechanisms, including the evolution and population dynamics of drug-sensitive and drug-resistant clones over time. Using DNA barcoding to trace individual prostate tumor cells in vivo , we find that the evolutionary path to acquired resistance to androgen receptor signaling inhibition (ARSI) is dependent on the timing of treatment. In established tumors, resistance occurs through polyclonal adaptation of drug-sensitive clones, despite the presence of rare subclones with known, pre-existing ARSI resistance...
March 20, 2024: bioRxiv
#33
JOURNAL ARTICLE
Eveliina Hanski, Susan Joseph, Aura Raulo, Klara M Wanelik, Áine O'Toole, Sarah C L Knowles, Tom J Little
Age is a key parameter in population ecology, with a myriad of biological processes changing with age as organisms develop in early life then later senesce. As age is often hard to accurately measure with non-lethal methods, epigenetic methods of age estimation (epigenetic clocks) have become a popular tool in animal ecology and are often developed or calibrated using captive animals of known age. However, studies typically rely on invasive blood or tissue samples, which limit their application in more sensitive or elusive species...
April 1, 2024: Molecular Ecology
#34
JOURNAL ARTICLE
Ziwen Chen, Qifu Li, Yi Lu, Gaoyangzi Huang, Ya Huang, Xianmei Pei, Yi Gong, Bingkui Zhang, Xin Tang, Zili Liu, Taipin Guo, Fanrong Liang
INTRODUCTION: Migraine is a common clinical disorder, ranks as the second most disabling disease worldwide, and often manifests with unilateral onset. Contralateral acupuncture (CAT), as a classical acupuncture method, has been proven to be effective in the treatment of migraine without aura (MWoA). However, its neural mechanisms have not been investigated using multimodal magnetic resonance imaging (MRI). METHODS AND ANALYSIS: In this multimodal neuroimaging randomized trial, a total of 96 female MWoA participants and 30 female healthy controls (HCs) will be recruited...
2024: Frontiers in Neuroscience
#35
JOURNAL ARTICLE
Shota Kosuge, Yuri Masaoka, Hideyo Kasai, Motoyasu Honma, Kouzou Murakami, Nobuyuki Yoshii, Keiko Watanabe, Takaaki Naito, Miku Kosuge, Misa Matsui, Daiki Shoji, Syunsuke Sakakura, Hidetomo Murakami, Masahiko Izumizaki
This study aimed to explore the relationship between gray matter volume changes and various clinical parameters in patients with migraine, focusing on symptom severity, quality of life, and states of depression and anxiety. Using a case-control design, we examined 33 patients with migraine, with or without aura, and 27 age-matched healthy subjects. We used magnetic resonance imaging to assess the volumes of 140 bilateral brain regions. Clinical evaluations included the Migraine Disability Assessment, the Migraine Specific Quality of Life Questionnaire, the Center for Epidemiologic Studies Depression scale, Spielberger's State and Trait Anxiety scales, and the Japanese version of the Montreal Cognitive Assessment...
2024: PloS One
#36
JOURNAL ARTICLE
Deidra Ansah, Allyson Doucet, Betul Yilmaz Furtun, Samuel Keller, Stephen Williams, Pina Patel, J Kevin Wilkes, Talha Niaz, Mira Trivedi, Shreya Sheth, Anitha Parthiban, Aura Sanchez Mejia
No abstract text is available yet for this article.
March 25, 2024: Journal of the American Society of Echocardiography
#37
JOURNAL ARTICLE
Carmen González-Ávila, David García-Azorín, Ane Mínguez-Olaondo, Laura Rubio-Flores, Raquel Lamas, Candela Nieves-Castellanos, Alba López-Bravo, Albert Muñoz-Vendrell, Sergio Campoy, Fernando Sebastian-Valles, Sonia Quintas
PURPOSE: Migraine is the comorbidity most frequently associated with visual snow syndrome (VSS), but the prevalence of VSS in patients with migraine (PWM) has not been studied. Our objective was to evaluate the frequency of VSS in PWM and to analyze if symptoms of VSS happened in a permanent or episodic manner (eVSS) in this population. METHODS: We conducted a multicenter observational cross-sectional study. PWM was recruited from headache units, and a survey about the presence of visual snow symptoms was administered...
March 27, 2024: Neurological Sciences
#38
JOURNAL ARTICLE
Aura-Cătălina Mocanu, Andreea-Elena Constantinescu, Mădălina-Andreea Pandele, Ștefan Ioan Voicu, Robert-Cătălin Ciocoiu, Dan Batalu, Augustin Semenescu, Florin Miculescu, Lucian-Toma Ciocan
The proposed strategy for the extrusion of printable composite filaments follows the favourable association of biogenic hydroxyapatite (HA) and graphene nanoplatelets (GNP) as reinforcement materials for a poly(lactic acid) (PLA) matrix. HA particles were chosen in the <40 μm range, while GNP were selected in the micrometric range. During the melt-mixing incorporation into the PLA matrix, both reinforcement ratios were simultaneously modulated for the first time at different increments. Cylindrical composite pellets/test samples were obtained only for the mechanical and wettability behaviour evaluation...
March 20, 2024: Biomimetics
#39
JOURNAL ARTICLE
Marta Araujo-Castro, Ana M García Cano, Aura D Herrera-Martínez
No abstract text is available yet for this article.
March 27, 2024: Polish Archives of Internal Medicine
#40
Bill Zhang, Irina Podkorytova, Ryan Hays, Ghazala Perven, Mark Agostini, Jay Harvey, Rodrigo Zepeda, Sasha Alick-Lindstrom, Marisara Dieppa, Alex Doyle, Rohit Das, Bradley Lega, Kan Ding
OBJECTIVE: Epilepsy patients with mesial temporal sclerosis (MTS) on imaging who are drug-resistant usually undergo epilepsy surgery without previous invasive evaluation. However, up to one-third of patients are not seizure-free after surgery. Prior studies have identified risk factors for surgical failure, but it is unclear if they are associated with bilateral or discordant seizure onset. METHODS: In this retrospective case series, we identified 17 epilepsy patients who had MRI-confirmed MTS but received invasive stereo-EEG (SEEG) evaluation before definitive intervention...
2024: Clinical Neurophysiology Practice
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