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https://www.readbyqxmd.com/read/29149432/ebola-in-the-netherlands-2014-2015-costs-of-preparedness-and-response
#1
Anita W M Suijkerbuijk, Corien M Swaan, Marie-Josee J Mangen, Johan J Polder, Aura Timen, Wilhelmina L M Ruijs
The recent epidemic of Ebola virus disease (EVD) resulted in countries worldwide to prepare for the possibility of having an EVD patient. In this study, we estimate the costs of Ebola preparedness and response borne by the Dutch health system. An activity-based costing method was used, in which the cost of staff time spent in preparedness and response activities was calculated based on a time-recording system and interviews with key professionals at the healthcare organizations involved. In addition, the organizations provided cost information on patient days of hospitalization, laboratory tests, personal protective equipment (PPE), as well as the additional cleaning and disinfection required...
November 17, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29148276/correction-to-albury-et-al-re-six-novel-rare-non-synonymous-mutations-for-migraine-without-aura-identified-by-exome-sequencing
#2
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29146952/migrainomics-identifying-brain-and-genetic-markers-of-migraine
#3
REVIEW
Dale R Nyholt, David Borsook, Lyn R Griffiths
Migraine is one of the world's most prevalent and disabling disorders and imposes an enormous socioeconomic burden. The exact causes of migraine are unknown, and no recognizable diagnostic pathological changes have been identified. Specific identifiable markers of migraine would aid diagnosis and could provide insight into the pathogenesis of the condition, with the potential to direct development of new therapeutics. In the past few years, advances in neuroimaging and genetic studies have provided the most substantial progress towards the identification of markers...
November 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29146234/the-value-of-patient-directed-brain-mri-scan-with-a-diagnosis-of-migraine
#4
William J Mullally, Kathryn E Hall
OBJECTIVE: To determine if a brain MRI scan in patients with a diagnosis of migraine, who insist on the performance of imaging, is of more benefit in detecting clinically significant unsuspected structural abnormalities than would be expected by chance. METHODS: This prospective, observational, single center study was performed from January 1, 2010 to December 31,2012 and included 100 subjects with a diagnosis of migraine and a normal neurologic exam. A brain MRI scan was performed on all patients, solely at their request, to detect an unsuspected clinically significant structural lesion...
November 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29143861/migraine-with-prolonged-aura-phenotype-and-treatment
#5
REVIEW
Michele Viana, Shazia Afridi
We review the published literature on migraine with prolonged aura (PA), specifically with regards to the phenotype and treatment options. PA is not uncommon. A recent study found that about 17% of migraine auras are prolonged and that 26% of patients with migraine with aura have experienced at least one PA. The characteristics of PA are similar to most typical auras with the exception of a higher number of aura symptoms (in particular sensory and/or dysphasic). There are no well-established treatments at present which target the aura component of migraine...
November 16, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29143207/contribution-of-eeg-in-transient-neurological-deficits
#6
Pierre Lozeron, Nadine Carole Tcheumeni, Sahar Turki, Hélène Amiel, Elodie Meppiel, Sana Masmoudi, Caroline Roos, Isabelle Crassard, Patrick Plaisance, Houria Benbetka, Jean-Pierre Guichard, Emmanuel Houdart, Hélène Baudoin, Nathalie Kubis
Identification of stroke mimics and 'chameleons' among transient neurological deficits (TND) is critical. Diagnostic workup consists of a brain imaging study, for a vascular disease or a brain tumour and EEG, for epileptiform discharges. The precise role of EEG in this diagnostic workup has, however, never been clearly delineated. However, this could be crucial in cases of atypical or incomplete presentation with consequences on disease management and treatment. We analysed the EEG patterns on 95 consecutive patients referred for an EEG within 7 days of a TND with diagnostic uncertainty...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29141582/a-novel-interaction-between-kinase-activities-in-regulation-of-cilia-formation
#7
Nicole DeVaul, Katerina Koloustroubis, Rong Wang, Ann O Sperry
BACKGROUND: The primary cilium is an extension of the cell membrane that encloses a microtubule-based axoneme. Primary cilia are essential for transmission of environmental cues that determine cell fate. Disruption of primary cilia function is the molecular basis of numerous developmental disorders. Despite their biological importance, the mechanisms governing their assembly and disassembly are just beginning to be understood. Cilia growth and disassembly are essential events when cells exit and reenter into the cell cycle...
November 15, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/29139115/risk-of-stroke-associated-with-use-of-estrogen-containing-contraceptives-in-women-with-migraine-a-systematic-review
#8
REVIEW
Huma U Sheikh, Jelena Pavlovic, Elizabeth Loder, Rebecca Burch
OBJECTIVE: Migraine with aura has been associated with increased risk of ischemic and hemorrhagic stroke. Prior studies have shown a further increase in risk in women using combined hormonal contraceptives (CHCs). This has led to guidelines recommending against use of CHCs in this population. We sought to assess whether the risk of stroke is associated with the dose of estrogen and whether there is evidence of synergism between migraine and CHCs. We also sought to assess whether an interaction effect exists between migraine and CHCs...
November 15, 2017: Headache
https://www.readbyqxmd.com/read/29136915/a-quantum-dot-based-lateral-flow-immunoassay-for-the-sensitive-detection-of-human-heart-fatty-acid-binding-protein-hfabp-in-human-serum
#9
Mihaela Savin, Carmen-Marinela Mihailescu, Iulia Matei, Dana Stan, Carmen Aura Moldovan, Marian Ion, Ion Baciu
We describe the preparation and validation of a novel lateral flow immunoassay test for the detection of human heart fatty acid binding protein (hFABP). Water-soluble CdTe quantum dots (QDs) were selected as the fluorescent label and were linked covalently to anti-hFABP antibodies. Upon conjugation, the secondary structure of the anti-hFABP was preserved and the fluorescence quantum yield of the CdTe QDs increased. The labelled antibodies were transferred to the immunoassay test strip and the antigen-antibody reaction was successfully performed...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29135965/comparison-of-ground-based-and-satellite-derived-solar-uv-index-levels-at-six-south-african-sites
#10
Jean-Maurice Cadet, Hassan Bencherif, Thierry Portafaix, Kévin Lamy, Katlego Ncongwane, Gerrie J R Coetzee, Caradee Y Wright
South Africa has been measuring the ground-based solar UV index for more than two decades at six sites to raise awareness about the impacts of the solar UV index on human health. This paper is an exploratory study based on comparison with satellite UV index measurements from the OMI/AURA experiment. Relative UV index differences between ground-based and satellite-derived data ranged from 0 to 45% depending on the site and year. Most of time, these differences appear in winter. Some ground-based stations' data had closer agreement with satellite-derived data...
November 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29130510/heterogenous-migraine-aura-symptoms-correlate-with-visual-cortex-fmri-responses
#11
Nanna Arngrim, Anders Hougaard, Khazar Ahmadi, Mark Bitsch Vestergaard, Henrik Winther Schytz, Faisal Mohammad Amin, Henrik Bo Wiberg Larsson, Jes Olesen, Michael B Hoffmann, Messoud Ashina
OBJECTIVE: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. METHODS: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham or physical exercise and photostimulation...
November 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29126355/elevated-circulating-endothelial-specific-micrornas-in-migraine-patients-a-pilot-study
#12
Chun-Yu Cheng, Shih-Pin Chen, Yi-Chu Liao, Jong-Ling Fuh, Yen-Feng Wang, Shuu-Jiun Wang
Background Evidence of vascular dysfunction in migraine is increasing. MicroRNAs (miRs) have emerged as important regulators of vascular endothelial functions. This exploratory study investigated whether circulating levels of miRs associated with endothelial function are altered in migraine patients. Methods Thirty patients with migraine (20-50 years old) without overt vascular risk factors and 30 sex- and age-matched healthy controls participated. The levels of four miRs that regulate endothelial function (miR-155, miR-126, miR-21, and Let-7g) were quantified and expressed in terms of fold changes (2(-ΔΔct)) relative to mean levels in the control group...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29126329/effect-of-benzo-a-pyrene-on-spindle-mis-orientation-and-fidelity-of-chromosome-segregation-in-lung-epithelial-beas-2b-cells
#13
Jose Thaiparambil, Oula Mansour, Randa El-Zein
Benzo[a]pyrene (B[a]P) is an environmental carcinogen found in tobacco smoke. It leads to high levels of DNA adducts in the lungs of cigarette smokers contributing to genomic instability. Alterations in the mitotic spindle apparatus play a major role in the generation of genomic instability through promoting chromosome mis-segregation and aneuploidy. To date, the effect of B[a]P exposure on altering the mitotic apparatus in normal lung epithelial cells remains unknown. In our study, BEAS-2B human bronchial epithelial cells were exposed to B[a]P and spindle dynamics were evaluated...
November 6, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29114247/elusive-role-of-the-cd94-nkg2c-nk-cell-receptor-in-the-response-to-cytomegalovirus-novel-experimental-observations-in-a-reporter-cell-system
#14
Aldi Pupuleku, Marcel Costa-García, Domènec Farré, Hartmut Hengel, Ana Angulo, Aura Muntasell, Miguel López-Botet
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with additional distinctive phenotypic and functional features. The mechanisms underlying the development of adaptive NK cells remain uncertain but some observations support the involvement of a cognate interaction of CD94/NKG2C with ligand(s) displayed by HCMV-infected cells. To approach this issue, the heterodimer and its adaptor (DAP12) were expressed in the human Jurkat leukemia T cell line; signaling was detected by transfection of a reporter plasmid encoding for Luciferase (Luc) under NFAT/AP1-dependent control...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29111146/medical-contraindications-to-estrogen-and-contraceptive-use-among-women-veterans
#15
Colleen P Judge, Xinhua Zhao, Florentina E Sileanu, Maria K Mor, Sonya Borrero
BACKGROUND: Women veterans have high rates of medical comorbidities and may be particularly vulnerable to adverse health outcomes associated with unintended pregnancy. OBJECTIVES: The objective of the study was to estimate the prevalence of medical contraindications to estrogen-containing combined hormonal contraception among women veterans of reproductive age and to evaluate the relationship between contraindications and contraceptive use. STUDY DESIGN: This was a secondary analysis of data from a cross-sectional, telephone-based survey with a national sample of 2302 female veterans, aged 18-45 years, who use the Veterans Administration Healthcare System for primary care...
October 27, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29105529/re-six-novel-rare-non-synonymous-mutations-for-migraine-without-aura-identified-by-exome-sequencing
#16
Cassie L Albury, Zachary Gerring, Astrid J Rodriguez-Acevedo
No abstract text is available yet for this article.
November 6, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29105356/binder-free-hybrid-titanium-niobium-oxide-carbon-nanofiber-mats-for-lithium-ion-battery-electrodes
#17
Aura Tolosa, Simon Fleischmann, Ingrid Grobelsek, Antje Quade, Eunho Lim, Volker Presser
This study introduces the synthesis of free-standing, binder-free, titanium-niobium oxide/carbon hybrid nanofibers for Li-ion battery applications. The one-pot synthesis offers a significant reduction of processing steps and avoids the use of environmentally unfriendly binder materials, making the approach highly sustainable. Tetragonal Nb2O5/C and monoclinic Ti2Nb10O29/C hybrid nanofibers synthesized at 1000 °C presented the highest electrochemical performance, with capacity values of 243 and 267 mAh∙g-1, respectively normalized to the electrode mass...
November 3, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29101860/correlation-between-extreme-fear-and-focal-cortical-dysplasia-in-anterior-cingulate-gyrus-evidence-from-a-surgical-case-of-refractory-epilepsy
#18
Liang Qiao, Tao Yu, Duanyu Ni, Xueyuan Wang, Cuiping Xu, Chang Liu, Guojun Zhang, Yongjie Li
Localizing the semiology of ictal fear and seizure onset in epilepsy patients is commonly challenging due to limited value of routine electroencephalography (EEG) and very few surgical attempts. Here we reported a case of refractory epilepsy characterized by aura of extreme fear and hypermotor seizures, in which the left (dominant hemisphere) anterior cingulate gyrus (ACG) was determined to be the epileptogenic zone (EZ) through multiple modalities of presurgical evaluation including analysis of high frequency oscillation on intracranial EEG...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29089238/-clinical-and-pathological-definition-of-temporal-medium-epilepsy-subtypes-with-hypocampic-sclerosis
#19
Gonzalo Olivares-Granados, Rosa María Ríos-Pelegrina, Jesús Ruiz-Giménez, Alberto Galdón-Castillo, Teresa Escobar-Delgado, Raimundo García Del Moral
BACKGROUND AND OBJECTIVE: Mesial temporal lobe epilepsy with hippocampal sclerosis is the most common cause of refractory epilepsy, and the most common indication for surgery. Although effective, surgery fails in up to 40% of patients. The objective of our study was to establish a correlation between the different histological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis and the prognosis, seizures control, side effects and anticonvulsivant drug withdrawal in patients with refractory epilepsy...
October 28, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29076927/the-etiological-relationship-between-migraine-and-sudden-hearing-loss
#20
Yildiz Arslan, İlker Burak Arslan, Huriye Aydin, Özlem Yağiz, Figen Tokuçoğlu, İbrahim Çukurova
OBJECTIVES: To investigate the relationship between sudden sensorineural hearing loss (SSNHL) and migraine, assess the prevalence of migraine in patients with idiopathic SSNHL, and determine a possible common vascular etiopathogenesis for migraine and SSNHL. STUDY DESIGN: Prospective cohort study. SETTING: Tertiary referral center. PATIENTS: This study initially assessed 178 SSNHL cases obtained from the Head and Neck Surgery Clinic patient database at a tertiary hospital in Turkey between January 2011 and March 2016...
December 2017: Otology & Neurotology
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