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https://www.readbyqxmd.com/read/28227063/diorama-enhances-efficiency-of-a-mass-casualty-incident-system-and-experimentation
#1
Aura Ganz, James M Schafer, Zhuorui Yang, Jun Yi, Gregory Ciottone, Aura Ganz, James M Schafer, Zhuorui Yang, Jun Yi, Gregory Ciottone, Zhuorui Yang, Aura Ganz, Jun Yi, Gregory Ciottone, James M Schafer
In this paper we show DIORAMA efficiency in a simulated Mass Casualty Incident drill. As shown by our results DIORAMA system has achieved orderly transport of patients from site of injury to collection point, all red before the yellow were transported (no order was obeyed in the paper drills). We also show that DIORAMA system was used by responders with very short training time and by responders that are not familiar with each other. The qualitative results show that DIORAMA system was found to be user friendly and useful in tracking patients and responders in real time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227062/vision-based-responders-localization-techniques-in-urban-search-and-rescue-scenarios
#2
Zhuorui Yang, Aura Ganz, Zhuorui Yang, Aura Ganz, Zhuorui Yang, Aura Ganz
In this paper, we introduce a vision-based localization algorithm that can accurately track responders during rescue operations in urban areas that are Global Navigation Satellite System (GNSS)-denied. The proposed algorithm works successfully with the rich visual features of an urban environment and obtains an average localization accuracy of 2.5 ft. In addition, we also provide a 3D representation of the disaster field which reflects the current conditions of the site.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227020/spatial-temporal-forensic-analysis-of-mass-casualty-incidents-using-video-sequences
#3
Hao Dong, Juechen Yin, James Schafer, Aura Ganz, Hao Dong, Juechen Yin, James Schafer, Aura Ganz, Juechen Yin, Hao Dong, James Schafer, Aura Ganz
In this paper we introduce DIORAMA based forensic analysis of mass casualty incidents (MCI) using video sequences. The video sequences captured on site are automatically annotated by metadata, which includes the capture time and the camera location and viewing direction. Using a visual interface the MCI investigators can easily understand the availability of video clips in specific areas of interest, and efficiently review them. The video-based forensic analysis system will enable the MCI investigators to better understand the rescue operations and subsequently improve training procedures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226410/patient-specific-computational-modeling-of-cortical-spreading-depression-via-diffusion-tensor-imaging
#4
Julia M Kroos, Isabella Marinelli, Ibai Diez, Jesus M Cortes, Sebastiano Stramaglia, Luca Gerardo-Giorda
Cortical Spreading Depression (CSD), a depolarization wave originating in the visual cortex and traveling towards the frontal lobe, is commonly accepted as a correlate of migraine visual aura. As of today, little is known about the mechanisms that can trigger or stop such phenomenon. However, the complex and highly individual characteristics of the brain cortex suggest that the geometry might have a significant impact in supporting or contrasting the propagation of CSD. Accurate patient-specific computational models are fundamental to cope with the high variability in cortical geometries among individuals, but also with the conduction anisotropy induced in a given cortex by the complex neuronal organisation in the grey matter...
February 22, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28224326/treatment-with-telmisartan-a-long-acting-angiotensin-ii-receptor-blocker-prevents-migraine-attacks-in-japanese-non-responders-to-lomerizine
#5
Ken Ikeda, Sayori Hanashiro, Yuichi Ishikawa, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Ken Miura, Takehisa Hirayama, Takanori Takazawa, Osamu Kano, Kiyokazu Kawabe, Yasuo Iwasaki
Lomerizine, calcium channel blocker, is the most used medication for migraine prophylaxis in Japan. The effectiveness of this drug is reported as 50-75%. Telmisartan is angiotensin II receptor blockers which plasma half-life is 24 h. We examined whether telmisartan has preventative benefits in lomerizine non-responsive migraineurs. Lomerizine non-responders received telmisartan (20 mg/day) for 3 months after the investigation period of 3 months. Blood pressure, frequency of headache days/month, headache severity, and doses of triptans and analgesics were analyzed by Wilcoxon signed rank test...
February 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28223480/in-vivo-imaging-reveals-that-pregabalin-inhibits-cortical-spreading-depression-and-propagation-to-subcortical-brain-structures
#6
Stuart M Cain, Barry Bohnet, Jeffrey LeDue, Andrew C Yung, Esperanza Garcia, John R Tyson, Sascha R A Alles, Huili Han, Arn M J M van den Maagdenberg, Piotr Kozlowski, Brian A MacVicar, Terrance P Snutch
Migraine is characterized by severe headaches that can be preceded by an aura likely caused by cortical spreading depression (SD). The antiepileptic pregabalin (Lyrica) shows clinical promise for migraine therapy, although its efficacy and mechanism of action are unclear. As detected by diffusion-weighted MRI (DW-MRI) in wild-type (WT) mice, the acute systemic administration of pregabalin increased the threshold for SD initiation in vivo. In familial hemiplegic migraine type 1 mutant mice expressing human mutations (R192Q and S218L) in the CaV2...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28221867/osimertinib-in-pretreated-t790m-positive-advanced-non-small-cell-lung-cancer-aura-study-phase-ii-extension-component
#7
James Chih-Hsin Yang, Myung-Ju Ahn, Dong-Wan Kim, Suresh S Ramalingam, Lecia V Sequist, Wu-Chou Su, Sang-We Kim, Joo-Hang Kim, David Planchard, Enriqueta Felip, Fiona Blackhall, Daniel Haggstrom, Kiyotaka Yoh, Silvia Novello, Kathryn Gold, Tomonori Hirashima, Chia-Chi Lin, Helen Mann, Mireille Cantarini, Serban Ghiorghiu, Pasi A Jänne
Purpose Osimertinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) selective for both EGFR-TKI sensitizing ( EGFRm) and T790M resistance mutations. AURA (NCT01802632) is a phase I/II clinical trial to determine the dose, safety, and efficacy of osimertinib. This article reports the results from the phase II extension component. Patients and Methods Patients with EGFR-TKI-pretreated EGFRm- and T790M-positive advanced non-small-cell lung cancer (NSCLC) received once-daily osimertinib 80 mg...
February 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28206756/effect-of-bioprocessing-on-the-in-vitro-colonic-microbial-metabolism-of-phenolic-acids-from-rye-bran-fortified-breads
#8
Ville Mikael Koistinen, Emilia Nordlund, Kati Katina, Ismo Mattila, Kaisa Poutanen, Kati Hanhineva, Anna-Marja Aura
Cereal bran is an important source of dietary fiber and bioactive compounds, such as phenolic acids. We aimed to study the phenolic acid metabolism of native and bioprocessed rye bran fortified refined wheat bread and to elucidate the microbial metabolic route of phenolic acids. After incubation in an in vitro colon model, the metabolites were analyzed using two different methods applying mass spectrometry. While phenolic acids were released more extensively from the bioprocessed bran bread and ferulic acid had consistently higher concentrations in the bread type during fermentation, there were only minor differences in the appearance of microbial metabolites, including the diminished levels of certain phenylacetic acids in the bioprocessed bran...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28202825/-ictal-speech-manifesting-as-sleep-talking-a-case-report
#9
Takehiro Suzuki, Yosuke Kakisaka, Yu Kitazawa, Kazutaka Jin, Shiho Sato, Masaki Iwasaki, Mayu Fujikawa, Yoshiyuki Nishio, Akitake Kanno, Nobukazu Nakasato
We present a 28-year-old female patient whose epilepsy started at the age of 19. MRI showed right perisylvian polymicrogyria. She exhibited various seizure symptoms, such as somatosensory aura involving the left leg, dyscognitive seizures, and amnesic seizures. Her mother indicated that the patient sometimes had "sleep talking", which was associated with presence of epileptic seizures of the next day. Long-term video electroencephalography (EEG) revealed that her episodes of "sleep talking" were epileptic events, specifically ictal speech, originating in the right hemisphere...
February 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28193695/cortical-spreading-depression-closes-the-paravascular-space-and-impairs-glymphatic-flow-implications-for-migraine-headache
#10
Aaron J Schain, Agustin Melo, Andrew M Strassman, Rami Burstein
Functioning of the glymphatic system, a network of paravascular tunnels through which cortical interstitial solutes are cleared from the brain, has recently been linked to sleep and traumatic brain injury, both of which can affect the progression of migraine. This led us to investigate the connection between migraine and the glymphatic system. Taking advantage of a novel in vivo method we developed to visualize the PVS in naïve uninjected mice using 2-photon microscopy, we show that a single wave of cortical spreading depression (CSD), an animal model of migraine aura, induces a rapid and nearly complete closure of the paravascular space (PVS) around surface as well as penetrating cortical arteries and veins lasting several minutes, and gradually recovering over 30 min...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28184165/visual-spatial-training-efficacy-in-children-affected-by-migraine-without-aura-a-multicenter-study
#11
Francesco Precenzano, Maria Ruberto, Lucia Parisi, Margherita Salerno, Agata Maltese, Beatrice Gallai, Rosa Marotta, Serena Marianna Lavano, Francesco Lavano, Michele Roccella
Routinely in the clinical practice, children affected by migraine without aura (MwA) tend to exhibit severe and persistent difficulties within cognitive processes such as attention, memory, and visual-motor integration (VMI) skills. The aim of this study was to assess the visual-spatial and visual-motor abilities among a sample of children with MwA and the effects of a specific computerized training. The study population was composed of 84 patients affected by MwA (39 girls and 45 boys; mean age: 8.91±2.46 years), and they were randomly divided into two groups (group A and group B) comparable for age (P=0...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28181231/are-blurred-vision-and-short-duration-visual-phenomena-migraine-aura-symptoms
#12
Deborah I Friedman, Randolph W Evans
No abstract text is available yet for this article.
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28181217/hypercoagulability-and-migraine
#13
Gretchen E Tietjen, Stuart A Collins
BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms...
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28178114/resistance-to-ceftriaxone-and-azithromycin-in-neisseria-gonorrhoeae-isolates-from-7-countries-of-south-america-and-the-caribbean-2010-2011
#14
Sidharath Dev Thakur, Pamela Araya, Graciela Borthagaray, Patricia Galarza, Alina Llop Hernandez, Daisy Payares, Olga Marina Sanabria Cruz, Maria Elena Trigoso Carvallo, Aura Helena Corredor, Jo-Anne R Dillon
Seven countries in Latin America and the Caribbean report on (2010 and 2011) the susceptibility of 2235 isolates of Neisseria gonorrhoeae to 6 antibiotics. Thirteen isolates had ceftriaxone minimum inhibitory concentrations (MICs) of 0.125 to ≥ 0.25 mg/L. The percentage of resistant isolates to the following antibiotics was: azithromycin, 1.0% to 1.7%; ciprofloxacin, 42.1% to 36.2%; penicillin, 31% to 35%; tetracycline, 21.8% to 22.6%.
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28176334/cesarean-section-trends-in-the-nordic-countries-a-comparative-analysis-with-the-robson-classification
#15
Aura Pyykönen, Mika Gissler, Ellen Løkkegaard, Thomas Bergholt, Steen C Rasmussen, Alexander Smárason, Ragnheiður I Bjarnadóttir, Birna Björg Másdóttir, Karin Källén, Kari Klungsoyr, Susanne Albrechtsen, Finn Egil Skjeldestad, Anna-Maija Tapper
INTRODUCTION: The cesarean rates are low but increasing in most Nordic countries. Using the Robson classification, we analyzed which obstetric groups have contributed to the changes in the cesarean rates. MATERIAL AND METHODS: Retrospective population-based registry study including all deliveries (3,398,586) between 2000 and 2011 in Denmark, Finland, Iceland, Norway and Sweden. The Robson group distribution, cesarean rate and contribution of each Robson group were analyzed nationally for four three-year time periods...
February 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28166210/a-water-mediated-allosteric-network-governs-activation-of-aurora-kinase-a
#16
Soreen Cyphers, Emily F Ruff, Julie M Behr, John D Chodera, Nicholas M Levinson
The catalytic activity of many protein kinases is controlled by conformational changes of a conserved Asp-Phe-Gly (DFG) motif. We used an infrared probe to track the DFG motif of the mitotic kinase Aurora A (AurA) and found that allosteric activation by the spindle-associated protein Tpx2 involves an equilibrium shift toward the active DFG-in state. Förster resonance energy transfer experiments show that the activation loop undergoes a nanometer-scale movement that is tightly coupled to the DFG equilibrium...
February 6, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28159058/migraine-and-cardiovascular-disease-in-women
#17
REVIEW
Katie M Linstra, Khatera Ibrahimi, Gisela M Terwindt, Marieke J H Wermer, Antoinette MaassenVanDenBrink
Migraine is responsible for high rates of disability. In addition, it is associated with an increased risk of cardiovascular disease. This association is not limited to the brain in the form of stroke, but includes cardiac ischemia. The increased risk is most consistently described in the female population and in particular for migraine with aura. This article reviews the current knowledge on migraine and the associated risk of cardiovascular disease, with a focus on female-specific factors.
March 2017: Maturitas
https://www.readbyqxmd.com/read/28158107/narrow-band-multi-filter-radiometer-for-total-ozone-content-measurements-mario-zucchelli-station-antarctica-campaign
#18
Salvatore Scaglione, Danilo Zola, Francesca Menchini, Ilaria Di Sarcina
The importance of ground-based measurements of ultraviolet radiation has increased since the discovery of the stratospheric ozone layer depletion. Spectroradiometers are the most widely used class of instruments, although the requirement to work in attended stations is sometimes limiting. In this work we present a filter radiometer, named F-RAD, with good optical stability, very short sampling time (1 min), and proven reliability. The instrument is based on a stand-alone functioning, making it suitable for operation in hostile environments...
February 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28157621/analysis-of-the-upper-cervical-spine-stiffness-during-axial-rotation-a-comparative-study-among-patients-with-tension-type-headache-or-migraine-and-asymptomatic-subjects
#19
P-M Dugailly, A Decuyper, W Salem, A De Boe, G V Espí-López, Y Lepers
BACKGROUND: Many studies reported the implication of the cervical musculoskeletal system in patients with tension type headache and migraine. The objective of this study is to investigate the upper cervical spine stiffness features in axial rotation among headache patients in comparison with a healthy population. METHODS: 48 subjects including 30 migraine patients with/without aura and 18 patients with tension-type headache, aged between 18 and 60years (mean 36, SD 11years) have been evaluated...
January 27, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28155572/exploring-the-role-of-microglia-in-cortical-spreading-depression-in-neurological-disease
#20
Mamoru Shibata, Norihiro Suzuki
Microglia play a pivotal role in innate immunity in the brain. During development, they mature from myeloerythroid progenitor cells in the yolk sac and colonize the brain to establish a resident population of tissue macrophages. In the postnatal brain, they exert phagocytosis and induce inflammatory response against invading pathogens. Microglia also act as guardians of brain homeostasis by surveying the microenvironment using motile processes. Cortical spreading depression (CSD) is a slowly propagating (2-5 mm/min) wave of rapid, near-complete depolarization of neurons and astrocytes followed by a period of electrical suppression of a distinct population of cortical neurons...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
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