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https://www.readbyqxmd.com/read/28344495/enantioselective-analysis-of-fluoxetine-in-pharmaceutical-formulations-by-capillary-zone-electrophoresis
#1
Melania Cârcu-Dobrin, Monica Budău, Gabriel Hancu, Laszlo Gagyi, Aura Rusu, Hajnal Kelemen
Fluoxetine is an antidepressant, a selective serotonin reuptake inhibitor (SSRI) used primarily in the treatment of major depression, panic disorder and obsessive compulsive disorder. Chiral separation of racemic fluoxetine is necessary due to its enantioselective metabolism. In order to develop a suitable method for chiral separation of fluoxetine, cyclodextrin (CD) modified capillary electrophoresis (CE) was employed. A large number of native and derivatized, neutral and ionized CD derivatives were screened to find the optimal chiral selector...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28341968/the-complex-interrelations-between-two-paroxysmal-disorders-headache-and-epilepsy
#2
REVIEW
Carlo Cianchetti, Giuliano Avanzini, Filippo Dainese, Vincenzo Guidetti
The interrelations between headache/migraine and epileptic seizures are an interesting topic, still lacking a systematization, which is the objective of the present revision. We organize the general setting on: (a) a distinction between pre-ictal, ictal, post-ictal and inter-ictal headaches, assuming "ictal" as epileptic seizure, and (b) the kind of headache, if it is of migraine type or not. Concerning pre-ictal migraine/headache, the necessity of its differentiation from an epileptic headache presenting as an aura of a seizure is stressed; this is connected with the indefiniteness of the term "migralepsy"...
March 24, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28340296/ultra-low-surface-recombination-velocity-in-passivated-ingaas-inp-nanopillars
#3
Aura Higuera-Rodriguez, Bruno Romeira, Simone Birindelli, Lachlan E Black, Barry Smalbrugge, Peter J van Veldhoven, Wilhelmus Erwin M M Kessels, Meint K Smit, Andrea Fiore
The III-V semiconductor InGaAs is a key material for photonics since it provides optical emission and absorption in the 1.55 μm telecommunication wavelength window. However, InGaAs suffers from pronounced non-radiative effects associated with its surface states, which affect the performance of nanophotonic devices for optical interconnects, namely nanolasers and nanodetectors. This work reports the strong suppression of surface recombination of undoped InGaAs/InP nanostructured semiconductor pillars using a combination of ammonium sulfide, (NH4)2S, passivation and silicon oxide, SiOx, coating...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28331065/urothelial-proliferation-and-regeneration-after-spinal-cord-injury
#4
F Aura Kullmann, Dennis R Clayton, Wily G Ruiz, Amanda Wolf-Johnson, Christian Gauthier, Anthony J Kanai, Lori A Birder, Gerard Apodaca
The basal, intermediate, and superficial cell layers of the urothelium undergo rapid and complete recovery following acute injury; however, the effects of chronic injury on urothelial regeneration have not been well defined. To address this discrepancy, we employed a mouse model to explore urothelial changes in response to spinal cord injury (SCI), a condition characterized by life-long bladder dysfunction. One-day post SCI there was a focal loss of umbrella cells, which are large cells that populate the superficial cell layer and normally express uroplakins (UPKs) and KRT20, but not KRT5, KRT14, or TP63...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28325558/l-citrulline-ameliorates-cerebral-blood-flow-during-cortical-spreading-depression-in-rats-involvement-of-nitric-oxide-and-prostanoids-mediated-pathway
#5
Yuki Kurauchi, Koichi Mokudai, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Masahiko Morita, Ayako Kamimura, Kunio Ishii
l-Citrulline is a potent precursor of l-arginine, and exerts beneficial effect on cardiovascular system via nitric oxide (NO) production. Migraine is one of the most popular neurovascular disorder, and imbalance of cerebral blood flow (CBF) observed in cortical spreading depression (CSD) contributes to the mechanism of migraine aura. Here, we investigated the effect of l-citrulline on cardiovascular changes to KCl-induced CSD. in rats. Intravenous injection of l-citrulline prevented the decrease in CBF, monitored by laser Doppler flowmetry, without affecting mean arterial pressure and heart rate during CSD...
February 17, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28314483/cost-analysis-of-the-history-ecg-age-risk-factors-and-initial-troponin-heart-pathway-randomized-control-trial
#6
Vinod K Chaubey, Mitkumar Patel, Auras R Atreya
No abstract text is available yet for this article.
February 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28295242/an-update-on-non-pharmacological-neuromodulation-for-the-acute-and-preventive-treatment-of-migraine
#7
Francesca Puledda, Peter J Goadsby
OBJECTIVE: To review current neuromodulation treatments available for migraine therapy, both in the acute and preventive setting. METHODS: The published literature was reviewed for studies reporting the effects of different neuromodulation strategies in migraine with and without aura. The use of non-invasive: single pulse transcranial magnetic stimulation, non-invasive vagal nerve stimulation, supraorbital nerve stimulation, and transcranial direct current stimulation, as well as invasive methods such as occipital nerve stimulation and sphenopalatine ganglion stimulation, are assessed...
March 13, 2017: Headache
https://www.readbyqxmd.com/read/28291671/molecular-characterization-of-kpc-producing-klebsiella-pneumoniae-isolated-from-patients-in-a-public-hospital-in-caracas-venezuela
#8
Aura Dayana Falco Restrepo, Mariel Alexandra Velásquez Nieves, Howard Takiff
INTRODUCTION: Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are amongst the most important causative agents of nosocomial infections worldwide. Isolates of this bacterium have been identified in Venezuela but little is known about their local spread. The aim of this study was to perform the molecular characterization of KPC-producing strains isolated from 2012 to 2013 in a public hospital in Caracas, Venezuela. METHODS: Twenty-two K. pneumoniae clinical isolates phenotypically classified as KPC producing were subjected to PCR screening for the presence of blaKPC genes and their location within transposon Tn4401...
March 11, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28290351/corrigendum-to-transfer-of-learning-radiographers-perceptions%C3%A2-of%C3%A2-simulation-based-educational-intervention-radiography-22-2016-%C3%A2-228-236
#9
S Aura, S Jordan, S Saano, K Tossavainen, H Turunen
No abstract text is available yet for this article.
February 2017: Radiography
https://www.readbyqxmd.com/read/28287494/synthetic-peptides-derived-from-bovine-lactoferricin-exhibit-antimicrobial-activity-against-e-coli-atcc-11775-s-maltophilia-atcc-13636-and-s-enteritidis-atcc-13076
#10
Nataly De Jesús Huertas Méndez, Yerly Vargas Casanova, Anyelith Katherine Gómez Chimbi, Edith Hernández, Aura Lucia Leal Castro, Javier Mauricio Melo Diaz, Zuly Jenny Rivera Monroy, Javier Eduardo García Castañeda
Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B-containing non-natural amino acids and the RWQWR motif were synthesized, purified, and characterized using RP-HPLC, MALDI-TOF mass spectrometry, and circular dichroism. The antibacterial activity of peptides against Escherichia coli ATCC 11775, Stenotrophomonas maltophilia ATCC 13636, and Salmonella enteritidis ATCC 13076 was evaluated. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined...
March 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28283958/pfo-and-migraine-is-there-a-role-for-closure
#11
REVIEW
Melissa Rayhill, Rebecca Burch
Observational studies suggest that closure of a patent foramen ovale for other indications may reduce or even eliminate migraine attacks, particularly migraine with aura. The first randomized clinical trial of patent foramen ovale (PFO) closure for prevention of migraine, the MIST trial, showed negative results. The results of the other two completed studies in this area have recently been published in the last year. PRIMA and PREMIUM were also both negative for their primary endpoints. The PREMIUM trial did show a reduction in headache days in the migraine with aura subgroup but the final results of this subset analysis have not been published...
March 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28283957/migraine-and-stroke-what-s-the-link-what-to-do
#12
REVIEW
Anna Gryglas, Robert Smigiel
Migraine and stroke are common, disabling neurologic disorders, with a high socioeconomic burden. A link between them has been proposed years ago, and various theories have been proposed to explain this bidirectional relation. However, the precise causes remain unclear. We briefly summarize existing hypotheses of this correlation seeking for recommendations for stroke prevention in migraineurs, if any exist. Among the strongest suggested theories of migraine-stroke association are cortical spreading depression, endovascular dysfunction, vasoconstriction, neurogenic inflammation, hypercoagulability, increased prevalence of vascular risk factors, shared genetic defects, cervical artery dissection, and patent foramen ovale...
March 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28283652/brca2-hypomorphic-missense-variants-confer-moderate-risks-of-breast-cancer
#13
Hermela Shimelis, Romy L S Mesman, Catharina Von Nicolai, Asa Ehlen, Lucia Guidugli, Charlotte Martin, Fabienne Mgr Calleja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M Aalfs, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann, Javier J Benitez, Natalia Bogdanova, Stig E Bojesen, Manjeet K Bolla, Anne-Lise Borresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Bruning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Ching-Yu Cheng, Ji-Yeob Choi, J Margriet Collée, Angela Cox, Simon S Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dork, Isabel Dos Santos Silva, Alison M Dunning, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Montserrat Garcia-Closas, Graham G Giles, Gord Glendon, Pascal Guenel, Christopher A Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B L Hogervorst, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli-Matti Kosma, Vessela Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubinski, Eva Machackova, Arto Mannermaa, Sara Margolin, Frederik Marme, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L Milne, Kenneth Muir, Susan L Neuhausen, Heli Nevanlinna, Janet E Olson, Curtis Olswold, Jan C Oosterwijk, Ana Osorio, Paolo Peterlongo, Julian Peto, Paul D P Pharoah, Katri Pylkäs, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Minouk J Schoemaker, Caroline M Seynaeve, Mitul Shah, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Susan L Slager, Melissa C Southey, Daniel O Stram, Anthony J Swerdlow, Soo Hwang Teo, Ian Tomlinson, Diana Torres, Therese Truong, Christi J van Asperen, Lizet E van der Kolk, Qin Wang, Robert Winqvist, Anna H Wu, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan C Walker, Lenka Foretova, Florentia Fostira, Kathleen Claes, Liliana Varesco, Setareh Moghadasi, Douglas F Easton, Amanda B Spurdle, Peter Devilee, Harry Vrieling, Alvaro N Monteiro, David E Goldgar, Aura Carreira, Maaike P G Vreeswijk, Fergus J Couch
Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between 19 BRCA1 and 33 BRCA2 missense substitution variants and breast cancer risk were investigated through a breast cancer case control study using genotyping data from 38 studies of predominantly European ancestry (41,890 cases and 41,607 controls) and nine studies of Asian ancestry (6,269 cases and 6,624 controls)...
March 10, 2017: Cancer Research
https://www.readbyqxmd.com/read/28281108/recognizing-cadasil-a-secondary-cause-of-migraine-with-aura
#14
REVIEW
John Glenn Burkett, Carrie Dougherty
PURPOSE OF REVIEW: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an important disease to consider in the differential diagnosis of migraine with aura. This review examines current literature regarding migraine in CADASIL, as well as diagnostic and treatment modalities. RECENT FINDINGS: Recent studies have shown that smoking is a modifiable risk factor for progression of CADASIL (Chabriat et al. in Stroke 47:4-11, 2015)...
April 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28275238/a-decade-of-global-volcanic-so2-emissions-measured-from-space
#15
S A Carn, V E Fioletov, C A McLinden, C Li, N A Krotkov
The global flux of sulfur dioxide (SO2) emitted by passive volcanic degassing is a key parameter that constrains the fluxes of other volcanic gases (including carbon dioxide, CO2) and toxic trace metals (e.g., mercury). It is also a required input for atmospheric chemistry and climate models, since it impacts the tropospheric burden of sulfate aerosol, a major climate-forcing species. Despite its significance, an inventory of passive volcanic degassing is very difficult to produce, due largely to the patchy spatial and temporal coverage of ground-based SO2 measurements...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270113/which-recommendations-are-considered-essential-for-outbreak-preparedness-by-first-responders
#16
Evelien Belfroid, Aura Timen, Jim E van Steenbergen, Anita Huis, Marlies E J L Hulscher
BACKGROUND: Preparedness is considered essential for healthcare organizations to respond effectively to outbreaks. In the current study we aim to capture the views of first responders on what they consider key recommendations for high quality preparedness. Furthermore, we identified the recommendations with the highest urgency from the perspective of first responders. METHODS: We chose a multistep approach using a systematic Delphi procedure. Previously extracted recommendations from scientific literature were presented to a national and two international expert panels...
March 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28269791/measuring-habitual-physical-activity-in%C3%A2-neuromuscular-disorders-a-systematic-review
#17
Aura Cecilia Jimenez-Moreno, Jane Newman, Sarah J Charman, Michael Catt, Michael I Trenell, Grainne S Gorman, Jean-Yves Hogrel, Hanns Lochmüller
BACKGROUND: Free-living or habitual physical activity (HPA) refers to someone's performance in his or her free-living environment. Neuromuscular disorders (NMD) manifest through HPA, and the observation of HPA can be used to identify clinical risks and to quantify outcomes in research. This review summarizes and analyses previous studies reporting the assessment of HPA in NMD, and may serve as the basis for evidence-based decision-making when considering assessing HPA in this population...
2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28268865/diorama-enhances-efficiency-of-a-mass-casualty-incident-system-and-experimentation
#18
Aura Ganz, James M Schafer, Zhuorui Yang, Jun Yi, Gregory Ciottone
In this paper we show DIORAMA efficiency in a simulated Mass Casualty Incident drill. As shown by our results DIORAMA system has achieved orderly transport of patients from site of injury to collection point, all red before the yellow were transported (no order was obeyed in the paper drills). We also show that DIORAMA system was used by responders with very short training time and by responders that are not familiar with each other. The qualitative results show that DIORAMA system was found to be user friendly and useful in tracking patients and responders in real time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268864/vision-based-responders-localization-techniques-in-urban-search-and-rescue-scenarios
#19
Zhuorui Yang, Aura Ganz
In this paper, we introduce a vision-based localization algorithm that can accurately track responders during rescue operations in urban areas that are Global Navigation Satellite System (GNSS)-denied. The proposed algorithm works successfully with the rich visual features of an urban environment and obtains an average localization accuracy of 2.5 ft. In addition, we also provide a 3D representation of the disaster field which reflects the current conditions of the site.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268824/spatial-temporal-forensic-analysis-of-mass-casualty-incidents-using-video-sequences
#20
Hao Dong, Juechen Yin, James Schafer, Aura Ganz
In this paper we introduce DIORAMA based forensic analysis of mass casualty incidents (MCI) using video sequences. The video sequences captured on site are automatically annotated by metadata, which includes the capture time and the camera location and viewing direction. Using a visual interface the MCI investigators can easily understand the availability of video clips in specific areas of interest, and efficiently review them. The video-based forensic analysis system will enable the MCI investigators to better understand the rescue operations and subsequently improve training procedures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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