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https://www.readbyqxmd.com/read/28811849/meniere-s-disease-and-vestibular-migraine-updates-and-review-of-the-literature
#1
REVIEW
Paul Tabet, Issam Saliba
The diagnosis of Meniere's disease (MD) and vestibular migraine (VM) is primarily based on clinical criteria and their differentiation is often difficult. Currently, there are no known definitive diagnostic tests that can reliably distinguish the two conditions. Patients with MD and patients with VM are treated differently, therefore improving the diagnosis of these two pathologies should avoid errors in management. A systematic review was conducted according to PRISMA guidelines. Medline-Ovid and Embase databases were used to conduct a thorough search of English-language publications dating from 1948 to March 2016...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28811802/clinical-features-and-risk-factors-for-irritable-bowel-syndrome-in-migraine-patients
#2
Chunlin Li, Shengyuan Yu, Huiying Li, Jin Zhou, Jieqiong Liu, Wenjing Tang, Lei Zhang
OBJECTIVE: Clinical and basic research increasingly suggests a correlation between migraine and irritable bowel syndrome (IBS). In this study, we aimed to explore the clinical features and risk factors for IBS in migraine patients. METHODS: This was a retrospective, cross-sectional study. A total of 1,112 consecutive patients from the internal medicine and emergency departments of three hospitals from June 2014 through 2016. A comprehensive interviewer-administered questionnaire was designed based on the International Classification of Headache Disorders, 3rd edition (beta version)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28807784/gabapentin-prevents-cortical-spreading-depolarization-induced-disinhibition
#3
Masoud Mesgari, Johanna Krüger, Christopher Theo Riemer, Maryam Khaleghi Ghadiri, Stjepana Kovac, Ali Goji
Cortical spreading depolarization (CSD) has an important role in brain diseases such as stroke, subarachnoid haemorrhage, migraine with aura, and epilepsy. Several anti-epileptic drugs (AEDs) are used to treat paroxysmal brain diseases and are thus known to suppress CSD. One of these AEDs is gabapentin (GBP) which has been traditionally used for treatment of some CSD-related neurological diseases. We applied intra- and extracellular recordings to investigate the effect of CSD on inhibitory post synaptic potentials (IPSPs) and synaptic properties of rodent neocortex after application of GBP...
August 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28806326/recurrent-vestibular-migraine-vertigo-attacks-associated-with-the-development-of-profound-bilateral-vestibulopathy-a-case-series
#4
Jacob L Wester, Akira Ishiyama, Gail Ishiyama
BACKGROUND: Bilateral vestibulopathy (BVP) is a debilitating condition characterized by gait ataxia, oscillopsia, and imbalance. OBJECTIVE: Case series of patients with migraine-linked vertigo spells and profound BVP. PATIENT 1:: A 69-year-old man presented with a history of recurrent severe vertigo spells lasting up to 3 days in duration associated with prostrating migraine headaches starting at age 60. His symptoms were misdiagnosed as an anxiety syndrome. At age 68, electronystagmography (ENG) revealed bilaterally absent caloric responses and complete BVP...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28806162/combined-hormonal-contraceptives-and-migraine-an-update-on-the-evidence
#5
REVIEW
Anne H Calhoun, Pelin Batur
Combined hormonal contraceptives are contraindicated in women who have migraine with aura, in whom these drugs can increase the risk of ischemic stroke. However, this contraindication is based on data from the 1960s and 1970s, when oral contraceptives contained much higher doses of estrogen. Stroke risk is not significantly increased with today's preparations, many of which contain less than 30 μg of ethinyl estradiol. Further, in continuous regimens, ultra-low-dose formulations--those that contain less than 20 μg of ethinyl estradiol--may help prevent menstrual migraine and reduce the frequency of aura...
August 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28797964/enhancing-biodegradation-of-c16-alkyl-quaternary-ammonium-compounds-using-an-oxygen-based-membrane-biofilm-reactor
#6
YenJung Sean Lai, Aura Ontiveros-Valencia, Zehra Esra Ilhan, Yun Zhou, Evelyn Miranda, Juan Maldonado, Rosa Krajmalnik-Brown, Bruce E Rittmann
Quaternary ammonium compounds (QACs) (e.g., hexadecyltrimethyl-ammonium bromide, CTAB) are emerging contaminants with widespread use as surfactants and disinfectants. Because the initial step of QAC biodegradation is mono-oxygenation, QAC degraders require O2, but normal aeration leads to serious foaming. Here, we developed and tested an oxygen-based membrane biofilm reactor (O2-MBfR) that delivers O2 by diffusion through the walls of hollow-membranes to a biofilm accumulating on the outer surface of membranes...
July 2, 2017: Water Research
https://www.readbyqxmd.com/read/28796589/the-role-of-migraine-headache-severity-associated-features-and-interactions-with-overweight-obesity-in-inhibitory-control
#7
Rachel Galioto, Kevin C O'Leary, John Gunstad, J Graham Thomas, Richard B Lipton, Jelena M Pavlović, Julie Roth, Lucille Rathier, Dale S Bond
AIM OF THE STUDY: While migraine and obesity are related and associated with reduced executive functioning, no study has examined whether obesity exacerbates executive dysfunction in migraine. This cross-sectional study examined whether overweight/obesity moderated associations of migraine severity and associated features with inhibitory control, one aspect of executive function. MATERIALS AND METHODS: Women (n = 124) aged 18-50 years old with overweight/obesity (body mass index (BMI) = 35...
August 10, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28791575/symptoms-and-clinical-parameters-of-pediatric-and-adolescent-migraine-by-gender-a-retrospective-cohort-study
#8
Tal Eidlitz-Markus, Avraham Zeharia
BACKGROUND: The available data on gender differences in clinical migraine parameters among pediatric patients are based on relatively few studies, which did not use the current version of the International Classification of Headache Disorders (ICHD) of the International Headache Society. The aim of the present study was to compare between males and females, demographic and clinical characteristics of children and adolescents with migraines diagnosed according to the ICDIII-beta version...
August 8, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28791330/computer-assisted-instruction-before-colonoscopy-is-as-effective-as-nurse-counselling-a-clinical-pilot-trial
#9
Govert Veldhuijzen, Michael Klemt-Kropp, Casper Noomen, Aura A Van Esch, Eric T Tjwa, Joost Drenth
BACKGROUND AND STUDY AIMS:  Better patient education prior to colonoscopy improves adherence to instructions for bowel preparation and leads to cleaner colons. We reasoned that computer assisted instruction (CAI) using video and 3 D animations followed by nurse contact maximizes the effectiveness of nurse counselling, increases proportion of clean colons and improves patient experience. PATIENTS AND METHODS:  Adults referred for colonoscopy in a high-volume endoscopy unit in the Netherlands were included...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28790971/recurrent-epileptic-auras-as-a-presenting-symptom-of-alzheimer-s-disease
#10
Rani A Sarkis, Kim C Willment, Seth A Gale, Barbara A Dworetzky
Seizures are a common co-morbidity during the course of Alzheimer's disease (AD) and in a subset of patients may be one of the presenting symptoms. In this case series, we highlight three patients with recurrent medically refractory epileptic auras whose work up ultimately lead to the diagnosis of AD. All three patients underwent prolonged EEG, serial neuropsychological testing, FDG-PET, cerebrospinal fluid (CSF) AD biomarkers, and MRI. CSF biomarkers were particularly helpful in two cases. These cases highlight the importance of having a high index of suspicion for AD in new onset "idiopathic" epilepsy in the elderly...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28782410/non-invasive-methods-for-measuring-vascular-changes-in-neurovascular-headaches
#11
Henrik W Schytz, Faisal M Amin, Juliette Selb, David A Boas
Vascular changes during spontaneous headache attacks have been studied over the last 30 years. The interest in cerebral vessels in headache research was initially due to the hypothesis of cerebral vessels as the pain source. Here, we review the knowledge gained by measuring the cerebral vasculature during spontaneous primary headache attacks with the use of single photon emission tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRA) and transcranial Doppler (TCD). Furthermore, the use of near-infrared spectroscopy in headache research is reviewed...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28779898/carbon-nanotube-release-from-polymers-into-a-food-simulant
#12
Yining Xia, Ilke Uysal Unalan, Maria Rubino, Rafael Auras
The release assessment of multi-walled carbon nanotubes (CNTs) was performed on two types of polymer-CNT nanocomposites: polypropylene (PP) and polyamide 6 (PA6) containing 3 wt% CNT. Nanocomposite films were prepared and then exposed to ethanol as a fatty-food simulant at 40 °C, and the amount of CNT release into ethanol was determined by ultraviolet-visible spectroscopy (UV-Vis) and graphite furnace atomic absorption spectrometry (GFAAS). The CNTs released into ethanol were visualized by transmission electron microscopy (TEM) and verified by Raman spectroscopy...
August 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28768147/production-of-human-recombinant-phenylalanine-hydroxylase-in-lactobacillus-plantarum-for-gastrointestinal-delivery
#13
Aura María Ramírez, Alexander Rodriguez-López, Andrea Ardila, Laura Beltran, Camilo Andres Patarroyo, Adelina Del Pilar Melendez, Oscar Fernando Sánchez, Carlos Javier Alméciga-Díaz
Phenylketonuria (PKU) is an autosomal recessive disorder caused by a defective phenylalanine hydroxylase (PAH), which catalyzes the hydroxylation of l-phenylalanine (l-Phe) to l-tyrosine (l-Tyr) in presence of the cofactor tetrahydrobiopterin (BH4). Defective PAH causes accumulation of phenylalanine, which has neurotoxic effects and leads to dermatological, behavioral, and neurocognitive problems. Treatments for this disease consist in life-long diets that are hard for patients to keep, or supplementation with BH4...
July 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28762753/migraine-in-mitochondrial-disorders-prevalence-and-characteristics
#14
Catello Vollono, Guido Primiano, Giacomo Della Marca, Anna Losurdo, Serenella Servidei
Background Migraine is a well-known feature of mitochondrial disorders (MDs). However, no systematic epidemiological data are available in large populations of patients. Aims The aim of this cross-sectional cohort study was to describe the prevalence and migraine characteristics in a large cohort of patients with mitochondrial encephalomyopathies. Methods We studied 93 consecutive patients with characterised MDs referred to our Neuromuscular Unit during a 12-month period. All patients (age range = 16-78 years; 31 men; 58 progressive external ophthalmoplegia [PEO], 12 myoclonic epilepsy with ragged red fibres [MERRF], eight mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes [MELAS], two mitochondrial neurogastrointestinal encephalomyopathy [MNGIE] and 13 other MDs) underwent a structured diagnostic headache interview using an operational diagnostic tool following the IHS criteria...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28751247/brief-report-modulation-of-biomarker-expression-by-osimertinib-results-of-the-paired-tumor-biopsy-cohorts-of-the-aura-phase-i-trial
#15
Kenneth S Thress, Vivien Jacobs, Helen K Angell, James Chih-Hsin Yang, Lecia V Sequist, Fiona Blackhall, Wu-Chou Su, Martin Schuler, Jürgen Wolf, Kathryn A Gold, Mireille Cantarini, J Carl Barrett, Pasi A Jänne
INTRODUCTION: Osimertinib is an oral, potent, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) selective for EGFR-TKI and T790M resistance mutations. To enhance understanding of osimertinib's mechanism of action, we aimed to evaluate the modulation of key molecular biomarkers post-osimertinib in paired clinical samples from the Phase I AURA trial. METHODS: Paired tumor biopsies were collected pre-study and following 15±7 days of osimertinib treatment (80 or 160 mg daily)...
July 24, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28750590/initiation-of-spreading-depression-by-synaptic-and-network-hyperactivity-insights-into-trigger-mechanisms-of-migraine-aura
#16
Lyudmila V Vinogradova
Background Cortical spreading depression (SD) is thought to underlie migraine aura but mechanisms of triggering SD in the structurally normal, well-nourished cortex of migraine patients remain unknown. Synaptic and network dysfunctions appear to underlie episodic neurological disorders, including migraine. The narrative review summarizes old and recent experimental evidence for triggering SD by synaptic/network mechanisms and discusses the relevance of the data to migraine pathogenesis. Our hypothesis is that under some conditions synaptic/network hyperactivity may reliably ignite SD, and this mechanism may underlie triggering migraine aura in patients...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28748768/allosteric-targeting-of-aurora-a-kinase-using-small-molecules-a-step-forward-towards-next-generation-medicines
#17
Resmi C Panicker, Anthony G Coyne, Rajavel Srinivasan
Aurora A (AurA) kinase is a key mitotic protein essential for carrying out numerous cellular functions. Overexpression or malfunction of this enzyme results in numerous human diseases most notably in cancer. Several small molecule inhibitors targeting the ATP binding site of this enzyme are in various stages of clinical development. However, ATP binding site inhibitors can result in selectivity problems often leading to undesirable off-target effects. Moreover, these drugs are prone to drug resistance problem rendering them unfit for long-term administration...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748412/pharmacokinetics-of-dfn-15-a-novel-oral-solution-of-celecoxib-versus-celecoxib-400-mg-capsules-a-randomized-crossover-study-in-fasting-healthy-volunteers
#18
Arindam Pal, Srinivas Shenoy, Anirudh Gautam, Sagar Munjal, Jing Niu, Mathangi Gopalakrishnan, Joga Gobburru
BACKGROUND: COX-2 inhibitors can be effective for acute migraine, but none is supplied in a rapidly absorbed, ready-to-use oral liquid formulation. DFN-15, a novel oral liquid formulation of celecoxib, is being developed for the acute treatment of migraine with or without aura. Clinical studies with this formulation are ongoing. OBJECTIVES: The objectives of the present study were to compare the bioavailability of DFN-15 with that of the commercial formulation of celecoxib 400-mg oral capsules (Celebrex(®)) and to determine the dose proportionality of DFN-15 in healthy fasted volunteers...
July 26, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28747203/migraine-and-percutaneous-patent-foramen-ovale-closure-a-systematic-review-and-meta-analysis
#19
Yu-Jie Shi, Jun Lv, Xing-Ting Han, Guo-Gang Luo
BACKGROUND: The association between patent foramen ovale (PFO) and migraine with aura (MA) is well established. However, the benefits of PFO closure are less certain in patients with migraine without aura (MwoA). METHODS: We systematically searched Pubmed for pertinent clinical studies published from January 2000 to July 2015. The primary end-point was the elimination or significant improvement of migraine symptoms after PFO closure. RESULTS: Upon screening an initial list of 315 publications, we identified eight studies that included 546 patients...
July 26, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28740841/migrainous-infarction-a-rare-and-often-overlooked-diagnosis
#20
REVIEW
Gabriel Afonso Dutra Kreling, Neuro Rodrigues de Almeida, Pedro José Dos Santos
Migraine is a neurological entity and a well-known independent risk factor for cerebral infarction, which mostly afflicts the young female population. Researching focal neurological signs in this subset of the population with the diagnosis of a neurological ischemic event should always take into account the migraine as the etiology or as an associated factor. The etiology of central nervous system (CNS) ischemia is considerable. Migraine, although rare, also may be included in this vast etiological range, which is called migrainous infarction...
April 2017: Autopsy & case reports
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