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https://www.readbyqxmd.com/read/29331612/arterial-spin-labeling-cerebral-perfusion-magnetic-resonance-imaging-in-migraine-aura-an-observational-study
#1
Marc E Wolf, Shuhei Okazaki, Philipp Eisele, Christina Rossmanith, Johannes Gregori, Martin Griebe, Matthias Günther, Achim Gass, Michael G Hennerici, Kristina Szabo, Rolf Kern
BACKGROUND: Changes in cerebral perfusion during migraine with aura (MA) have been assessed mainly using dynamic susceptibility contrast (DSC) magnetic resonance perfusion imaging. A contrast agent-free method to assess these changes would be desirable. We assessed changes in cerebral perfusion during MA using arterial spin labeling (ASL) perfusion magnetic resonance imaging. METHODS: We investigated 4 patients with a standardized protocol including ASL perfusion imaging during MA (n = 2) or early headache phase (n = 2) and asymptomatic follow-up...
January 10, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29327224/prevalence-and-clinical-characteristics-of-headache-in-juvenile-myoclonic-epilepsy-experience-from-a-tertiary-epilepsy-center
#2
Metin Dedei Daryan, Betül Tekin Güveli, Sezin Alpaydın Baslo, Kasım Mulhan, Hüseyin Sarı, Zeynep Ezgi Balçık, Dilek Ataklı
The comorbidity of headache and epilepsy is often seen in neurological practice. The objective of this study was to assess the prevalence, types of, and risk factors for headache in juvenile myoclonic epilepsy (JME). We assessed a total of 200 patients and 100 healthy controls in our study. Headache was classified in participants using a self-administered questionnaire. Demographical, clinical features and headache characteristics were recorded. Seizure and headache temporal profiles were noted. Headache was present in 111 (56%) patients and 50 (50%) healthy participants...
January 11, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29326138/cerebellar-hypoperfusion-in-migraine-attack-incidence-and-significance
#3
F Kellner-Weldon, M El-Koussy, S Jung, M Jossen, P P Klinger-Gratz, R Wiest
BACKGROUND AND PURPOSE: Patients diagnosed with migraine with aura have an increased lifetime risk of ischemic stroke. It is not yet clear whether prolonged cortical hypoperfusion during an aura increases the immediate risk of cerebellar infarction because it may induce crossed cerebellar diaschisis and subsequent tissue damage. To address this question, we retrospectively analyzed potential relationships between cortical oligemia and cerebellar hypoperfusion in patients with migraine with aura and their potential relation to small infarct-like cerebellar lesions...
January 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29310650/parasitaemia-data-and-molecular-characterization-of-haemoproteus-catharti-from-new-world-vultures-cathartidae-reveals-a-novel-clade-of-haemosporida
#4
Michael J Yabsley, Ralph E T Vanstreels, Ellen S Martinsen, Alexandra G Wickson, Amanda E Holland, Sonia M Hernandez, Alec T Thompson, Susan L Perkins, Christopher J West, A Lawrence Bryan, Christopher A Cleveland, Emily Jolly, Justin D Brown, Dave McRuer, Shannon Behmke, James C Beasley
BACKGROUND: New World vultures (Cathartiformes: Cathartidae) are obligate scavengers comprised of seven species in five genera throughout the Americas. Of these, turkey vultures (Cathartes aura) and black vultures (Coragyps atratus) are the most widespread and, although ecologically similar, have evolved differences in morphology, physiology, and behaviour. Three species of haemosporidians have been reported in New World vultures to date: Haemoproteus catharti, Leucocytozoon toddi and Plasmodium elongatum, although few studies have investigated haemosporidian parasites in this important group of species...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29310571/knowledge-perceptions-and-media-use-of-the-dutch-general-public-and-healthcare-workers-regarding-ebola-2014
#5
Lianne G C Schol, Madelief Mollers, Corien M Swaan, Desirée J M A Beaujean, Albert Wong, Aura Timen
BACKGROUND: The Ebola outbreak in West-Africa triggered risk communication activities to promote adequate preventive behaviour in the Netherlands. Our study investigated the level of knowledge, perceptions, and media use regarding Ebola. METHODS: In December 2014, an online questionnaire was administered to the Dutch population (n = 526) and Health Care Workers (HCW) (n = 760). RESULTS: The mean knowledge score (range 0-15) of HCW (m = 13...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29305185/predictors-of-outcome-after-surgery-in-134-children-with-drug-resistant-tle
#6
Ashalatha Radhakrishnan, Ramshekhar Menon, Mathew Abraham, George Vilanilam, Suvasini Sharma, Bejoy Thomas, Chandrashekharan Kesavadas, Ajith Cherian, Raviprasad Varma, Sanjeev V Thomas
PURPOSE: To determine the factors predicting seizure outcome in children who underwent anterior temporal lobectomy (ATL) for drug-resistant temporal lobe epilepsy (TLE). METHODS: Among the 664 patients who underwent ATL for TLE from 1995 to 2008, there were 134 children. "Excellent" outcome in them was defined as seizure freedom during the entire follow-up (Engel class I a); "good outcome", if in remission last 2 years, and the rest as "unfavorable outcome". To identify the potential predictors of seizure recurrence, the attributes of recurred and non-recurred groups was compared by univariate and multivariate analysis...
January 2, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29302188/migraine-in-young-females-with-irritable-bowel-syndrome-still-a-challenge
#7
Doina Georgescu, Daniela Reisz, Camelia Vidita Gurban, Liviu Andrei Georgescu, Ioana Ionita, Oana Elena Ancusa, Daniel Lighezan
Migraine without aura is frequently reported in female patients with irritable bowel syndrome (IBS), but knowledge about the relationship between these two conditions is still lacking. This study was aimed to explore the particularities of migraine without aura in young female patients with IBS in order to establish a possible link between them. From a cohort of young female patients hospitalized with IBS in the Internal Medicine Department, 30 joined this pilot study, and they were assigned into two groups on the basis of presence or absence of migraine...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29301160/-pharmacotherapy-of-vestibular-disorders-nystagmus-and-cerebellar-disorders
#8
K Feil, N Böttcher, O Kremmyda, C Muth, J Teufel, A Zwergal, T Brandt, M Strupp
There are currently different groups of drugs for the pharmacotherapy of vertigo, nystagmus and cerebellar disorders: antiemetics; anti-inflammatories, antimenieres, and antimigraineous medications and antidepressants, anticonvulsants, aminopyridines as well as acetyl-DL-leucine. In acute unilateral vestibulopathy, corticosteroids improve the recovery of peripheral vestibular function, but currently there is not sufficient evidence for a general recommendation. There is insufficient evidence to support the view that 16 mg t...
January 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29299688/gamma-aminobutyric-acid-gaba-receptors-gabra4-gabre-and-gabrq-gene-polymorphisms-and-risk-for-migraine
#9
Elena García-Martín, Gara Esguevillas, Mercedes Serrador, Hortensia Alonso-Navarro, Francisco Navacerrada, Gemma Amo, Esteban García-Albea, José A G Agúndez, Félix Javier Jiménez-Jiménez
Several biochemical, pharmacological, neurophysiological and experimental data suggest a possible role of gamma-aminobutyric acid (GABA) in the pathogenesis of migraine. We investigated the possible association of the most common single nucleotide polymorphisms (SNPs) in the GABA receptor alpha4 (GABRA4), epsilon (GABRE), and theta (GABRQ) genes with the risk for migraine. A TaqMan-based qPCR assay designed to detect the most common SNPs in the GABRA4 (rs2229940), GABRE (rs1139916), and GABRQ (rs3810651) was performed in 197 migraine patients and 394 age- and gender-matched controls...
January 3, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29287658/assessment-of-the-rate-of-premolar-extraction-space-closure-in-the-maxillary-arch-with-the-acceledent-aura-appliance-vs-no-appliance-in-adolescents-a%C3%A2-single-blind-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Peter Miles, Elizabeth Fisher, Nikolaos Pandis
INTRODUCTION: The purpose of this 2-arm parallel trial was to assess the effect of the AcceleDent Aura appliance (OrthoAccel Technologies, Houston, Tex) on the rate of maxillary premolar extraction space closure in adolescent patients. METHODS: Forty Class II adolescents treated with full fixed appliances and maxillary premolar extractions participated in this randomized clinical trial. They were recruited in a private practice and treated by 1 clinician. Randomization was accomplished in blocks of 10 patients assigned to either a no-appliance group or the AcceleDent Aura appliance group with the allocations concealed in opaque, sealed envelopes...
January 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29279712/case-report-migrainous-infarct-without-aura
#11
Kamesh Gupta, Anurag Rohatgi, Shivani Handa
Background: Stroke in a migraine with aura has been documented in several cases, even deserving the merit of a classification as complicated migraine. Herein, we present a rare case of migrainous infarct without aura. The diagnosis was challenging due to lack of risk factors. The patient was unique in not having any other comorbidities. Case Presentation: The case is of a 21-year-old female presenting with right-sided hemiplegia and facial drooping. She had had an index presentation of throbbing headaches for the past 2 years, typical of a migraine but not preceded by any aura symptoms...
September 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/29259244/hydrogen-and-nitrogen-codoping-of-anatase-tio2-for-efficiency-enhancement-in-organic-solar-cells
#12
Maria Vasilopoulou, Nikolaos Kelaidis, Ermioni Polydorou, Anastasia Soultati, Dimitris Davazoglou, Panagiotis Argitis, Giorgos Papadimitropoulos, Dimitris Tsikritzis, Stella Kennou, Florian Auras, Dimitra G Georgiadou, Stavros-Richard G Christopoulos, Alexander Chroneos
TiO2 has high chemical stability, strong catalytic activity and is an electron transport material in organic solar cells. However, the presence of trap states near the band edges of TiO2 arising from defects at grain boundaries significantly affects the efficiency of organic solar cells. To become an efficient electron transport material for organic photovoltaics and related devices, such as perovskite solar cells and photocatalytic devices, it is important to tailor its band edges via doping. Nitrogen p-type doping has attracted considerable attention in enhancing the photocatalytic efficiency of TiO2 under visible light irradiation while hydrogen n-type doping increases its electron conductivity...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29251523/perivascular-neurotransmitters-regulation-of-cerebral-blood-flow-and-role-in-primary-headaches
#13
Simona D Frederiksen, Kristian A Haanes, Karin Warfvinge, Lars Edvinsson
In order to understand the nature of the relationship between cerebral blood flow (CBF) and primary headaches, we have conducted a literature review with particular emphasis on the role of perivascular neurotransmitters. Primary headaches are in general considered complex polygenic disorders (genetic and environmental influence) with pathophysiological neurovascular alterations. Identified candidate headache genes are associated with neuro- and gliogenesis, vascular development and diseases, and regulation of vascular tone...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29250242/new-migraine-with-visual-disturbance-after-cryoballoon-ablation-of-atrial-fibrillation
#14
Annupreet Nadha, Eric S Williams
We report the case of a 58-year-old woman who developed a headache and visual disturbances after a cryoballoon ablation procedure for atrial fibrillation at our institution. She presented to the emergency department four days post ablation and was admitted the hospital for overnight observation. Serial neurological examinations and neuroimaging were unremarkable for stroke or transient ischemic attack. The patient had some brief transient visual changes which resolved completely after several days, with no further clinical sequelae...
October 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29249325/outcomes-in-patients-with-non-small-cell-lung-cancer-and-acquired-thr790met-mutation-treated-with-osimertinib-a-genomic-study
#15
Chia-Chi Lin, Jin-Yuan Shih, Chong-Jen Yu, Chao-Chi Ho, Wei-Yu Liao, Jih-Hsing Lee, Tzu-Hsiu Tsai, Kang-Yi Su, Min-Shu Hsieh, Yih-Leong Chang, Ya-Ying Bai, Derek De-Rui Huang, Kenneth S Thress, James Chih-Hsin Yang
BACKGROUND: Osimertinib is approved for the treatment of non-small-cell lung cancer in patients who develop the EGFR Thr790Met mutation after treatment with epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs). We assessed outcomes in patients with non-small-cell lung cancer and the EGFR Thr790Met mutation who were treated with osimertinib, a third-generation EGFR TKI, after previous treatment failure with one or more other EGFR TKIs. METHODS: Eligible patients had been enrolled at one centre in the AURA study, had shown resistance to a previous EGFR TKI, and had EGFR-activating mutations and acquired Thr790Met mutation detectable in tumour tissue or plasma...
December 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29247383/adjusted-indirect-comparison-using-propensity-score-matching-of-osimertinib-to-platinum-based-doublet-chemotherapy-in-patients-with-egfrm-t790m-nsclc-who-have-progressed-after-egfr-tki
#16
Helen Mann, Frank Andersohn, Carolyn Bodnar, Tetsuya Mitsudomi, Tony S K Mok, James Chih-Hsin Yang, Christopher Hoyle
BACKGROUND AND OBJECTIVE: An adjusted indirect comparison was conducted to assess efficacy outcomes, particularly overall survival (OS), of osimertinib versus platinum-based doublet chemotherapy in patients with epidermal growth factor receptor-mutated (EGFRm) T790M mutation-positive non-small-cell lung cancer (NSCLC) who had progressed following an EGFR tyrosine kinase inhibitor (TKI). Analysis of treatment effect from two separate trials had the potential to more accurately estimate the magnitude of OS benefit due to absence of confounding due to treatment switching from the control arm to the osimertinib arm of the ongoing randomized control trial, AURA3...
December 15, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29239213/features-of-aura-in-paediatric-migraine-diagnosed-using-the-ichd-3-beta-criteria
#17
Martina Balestri, Laura Papetti, Daniela Maiorani, Alessandro Capuano, Samuela Tarantino, Barbara Battan, Federico Vigevano, Massimiliano Valeriani
Background In children and adolescents, the prevalence rate of migraine with aura is 1.6%. Few studies concerning migraine with aura features in paediatric population have been reported. Aim The aim of our study was to investigate clinical features of aura in a retrospective cohort of children with migraine with aura. Furthermore, we studied whether the International Classification of Headache Disorder (ICHD) 3 beta version criteria could efficiently detect migraine with aura in a paediatric population. Results We included 164 patients who experienced aura associated with headache (mean age 9...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29239212/sarcoma-family-kinase-activity-is-required-for-cortical-spreading-depression
#18
Fan Bu, Yan Wang, Liwen Jiang, Dongqing Ma, John P Quinn, Minyan Wang
Objectives Sarcoma family kinase activity is associated with multiple diseases including ischemia and cancer; however, its role in the mechanism of migraine aura has been less well characterised. This study aims to investigate whether sarcoma family kinase is required for cortical spreading depression. Methods Cortical spreading depression was induced by topical application of K+ to the cerebral cortex and was monitored using electrophysiology in rats, and intrinsic optical signal in mouse brain slices. Drugs were perfused into the contralateral cerebral ventricle for pharmacological manipulations in rats...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29235107/headache-characteristics-and-clinical-features-of-elderly-migraine-patients
#19
Pablo de Rijk, Noémie Resseguier, Anne Donnet
OBJECTIVE: To investigate the headache characteristics and clinical features of elderly migraine patients at a tertiary headache center. METHODS: We retrospectively reviewed 239 records of migraine patients, over the age of 64 at the first visit, who had migraine as defined by the International Classification of Headache Disorders 3rd edition (beta version) from 2006 to 2015 based on the Marseille registry at Timone Hospital. RESULTS: 13.8% (33/239) patients had migraine with aura only, 13...
December 13, 2017: Headache
https://www.readbyqxmd.com/read/29234134/anatomical-evidence-for-scent-guided-foraging-in-the-turkey-vulture
#20
Nathan P Grigg, Justin M Krilow, Cristian Gutierrez-Ibanez, Douglas R Wylie, Gary R Graves, Andrew N Iwaniuk
The turkey vulture (Cathartes aura) is a widespread, scavenging species in the Western Hemisphere that locates carrion by smell. Scent guided foraging is associated with an expansion of the olfactory bulbs of the brain in vertebrates, but no such neuroanatomical data exists for vultures. We provide the first measurements of turkey vulture brains, including the size of their olfactory bulbs and numbers of mitral cells, which provide the primary output of the olfactory bulbs. Comparative analyses show that the turkey vulture has olfactory bulbs that are 4× larger and contain twice as many mitral cells as those of the sympatric black vulture (Coragyps atratus), despite having brains that are 20% smaller...
December 12, 2017: Scientific Reports
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