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https://www.readbyqxmd.com/read/27891378/isoniazid-induced-lupus-presenting-as-oral-mucosal-ulcers-with-pancytopenia
#1
Ria Shah, Padmaraj Ankale, Kanishk Sinha, Aparna Iyer, T K Jayalakshmi
Drug Induced Lupus Erythematous (DILE) is a rare adverse reaction to a large variety of drugs including Isoniazid (INH), with features resembling idiopathic Systemic Lupus Erythematosus (SLE). Diagnosis require identification of a temporal relationship between drug administered and symptom. It is an idiosyncratic reaction, with no pre-existing lupus. Our case highlights a rare presentation of isoniazid induced lupus with profound pancytopenia and mucosal ulcers, thus posing a diagnostic challenge. The patient was on multidrug treatment for pulmonary and knee joint tuberculosis...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27730777/ovarian-insufficiency-is-major-short-term-toxicity-in-systemic-lupus-erythematosus-patients-treated-with-cyclophosphamide
#2
Gurmeet Singh, Ramnath Misra, Amita Aggarwal
OBJECTIVE: To study the toxicities associated with pulse cyclophosphamide therapy and to compare them with patients without cyclophosphamide exposure. METHODS: In this retrospective cross-sectional observational study Systemic Lupus Erythematosus (SLE) patients who had received immunosuppressive agents in the past were interviewed in the Out Patient Department for drug related toxicities. Patients were asked about the any history of tuberculosis, herpes zoster, hemorrhagic cystitis or ovarian toxicity in the past...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27708968/a-case-of-systemic-lupus-erythematosus-with-multiple-nodules-in-the-bilateral-lungs-and-vertebrae
#3
Takuma Tsuzuki Wada, Kojiro Sato, Toshihide Mimura
We encountered a case of a middle-aged woman with systemic lupus erythematosus. As the patient had progressive peripheral neuropathy including foot drop, we intended to treat her with intensive immunosuppressive therapy as soon as possible. Pretreatment assessment, however, revealed multiple nodular lesions in the lungs and bones, suggesting disseminated tumor metastasis or miliary tuberculosis. To our surprise, gallium and bone scintigraphy as well as cytodiagnosis revealed no sign of malignancy or infection, leading us to suspect the presence of another multisystem disorder...
March 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27437280/acute-bilateral-tuberculous-pneumonia-in-a-patient-with-systemic-lupus-erythematosus
#4
Raghavendra Rao, Rama Bhat, Nitin Bhat, Savio D'Souza, Venkata Chenchaiah
Pulmonary tuberculosis is a common infection associated with immunocompromised state. It usually presents with fibrosis or fibrocavitary lesions in the lung. We report a case of bilateral tuberculous pneumonia of acute presentation in a young lady who was being treated for systemic lupus erythematosus.
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27432810/genetic-selection-pressure-in-tlr9-gene-may-enforce-risk-for-sle-in-indian-tamils
#5
J H Yusuf, D Kaliyaperumal, M Jayaraman, G Ramanathan, P Devaraju
OBJECTIVES: Lupus is a classical systemic autoimmune disease with genetics as one of the well known causative factors for the disease pathogenesis. Toll-like receptors are the major pattern recognition receptors associated with innate immunity and also act as an interface with the adaptive immunity. Genetic polymorphisms in genes encoding TLRs were implicated in the development of infections, malignancies and autoimmune diseases. TLR9 is a member of TLR family, and recognizes the CpG DNA motifs of pathogens...
July 17, 2016: Lupus
https://www.readbyqxmd.com/read/27408688/case-report-kikuchi-fujimoto-disease-a-diagnostic-and-therapeutic-dilemma-following-pretransplant-nephrectomy-for-a-2-35-kg-kidney
#6
Arvind P Ganpule, Jaspreet Singh Chabra, Abhishek G Singh, Gopal R Tak, Shailesh Soni, Ravindra Sabnis, Mahesh Desai
Kikuchi-Fujimoto disease (KFD) is an extremely rare disease with a worldwide distribution and higher prevalence in Asians. It is a benign and self-limiting disorder, characterized by regional cervical lymphadenopathy accompanied with mild fever and night sweats. Lymph node histopathology is diagnostic and treating physicians should be aware of this entity as it may mimic other systemic diseases like systemic lupus erythematosus, tuberculosis, malignant lymphoma, and more rarely adenocarcinoma. Key features on lymph node biopsy are fragmentation, necrosis and karyorrhexis...
2016: F1000Research
https://www.readbyqxmd.com/read/27267647/miliary-tuberculosis-a-severe-opportunistic-infection-in-juvenile-systemic-lupus-erythematosus-patients
#7
Priscilla S Freire, João D Montoni, Aline S M Ribeiro, Heloísa H Marques, Thais Mauad, Clovis A Silva
INTRODUCTION: One of the main issues in juvenile systemic lupus erythematosus (JSLE) patients is infection, such as tuberculosis (TB). Of note, SLE patients are susceptible to pulmonary and extrapulmonary TB. However, to our knowledge, this contagious disease was rarely reported in pediatric lupus population, particularly diffuse or miliary TB. Therefore, from January 1983 to December 2011, 5,635 patients were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for SLE...
May 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27149470/a-rare-case-of-disseminated-tuberculosis-of-the-bone-marrow-in-systemic-lupus-erythematosus-case-report
#8
Dongying Chen, Zheng Yang, Ying Yang, Zhongping Zhan, Xiuyan Yang
Patients with systemic lupus erythematosus (SLE) are susceptible to tuberculosis (TB), especially in endemic areas such as China. The variable and nonspecific clinical features of disseminated TB often leads to an erroneous or misdiagnosis. When a patient presents with TB of the bone marrow, the clinical condition is more perplexing and the prognosis is typically poor. Till now, there is no case report after apatinib came in the market.Here, we report a case of TB of the bone marrow accompanied with SLE. The patient exhibited remarkable features, including widespread lesions in the lungs, spinal vertebrae, sacrum, and ilium that were found to be consistent with TB of the bone marrow after histopathological examination...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27114460/heterozygous-stat1-gain-of-function-mutations-underlie-an-unexpectedly-broad-clinical-phenotype
#9
Julie Toubiana, Satoshi Okada, Julia Hiller, Matias Oleastro, Macarena Lagos Gomez, Juan Carlos Aldave Becerra, Marie Ouachée-Chardin, Fanny Fouyssac, Katta Mohan Girisha, Amos Etzioni, Joris Van Montfrans, Yildiz Camcioglu, Leigh Ann Kerns, Bernd Belohradsky, Stéphane Blanche, Aziz Bousfiha, Carlos Rodriguez-Gallego, Isabelle Meyts, Kai Kisand, Janine Reichenbach, Ellen D Renner, Sergio Rosenzweig, Bodo Grimbacher, Frank L van de Veerdonk, Claudia Traidl-Hoffmann, Capucine Picard, Laszlo Marodi, Tomohiro Morio, Masao Kobayashi, Desa Lilic, Joshua D Milner, Steven Holland, Jean-Laurent Casanova, Anne Puel
Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds originating from 40 countries from 5 continents. Demographic data, clinical features, immunological parameters, treatment, and outcome were recorded. The median age of the 274 patients was 22 years (range, 1-71 years); 98% of them had CMC, with a median age at onset of 1 year (range, 0-24 years)...
June 23, 2016: Blood
https://www.readbyqxmd.com/read/27073889/low-density-granulocytes-are-elevated-in-mycobacterial-infection-and-associated-with-the-severity-of-tuberculosis
#10
Yating Deng, Jianqing Ye, Qing Luo, Zhikun Huang, Yiping Peng, Guoliang Xiong, Yang Guo, Hong Jiang, Junming Li
Tuberculosis remains a global health problem caused by infection with Mycobacterium tuberculosis. Numerous studies have established a close correlation between the development of tuberculosis and the roles of neutrophils. Recently, a distinct population of CD15+ granulocytes was found to be present in the peripheral blood mononuclear cell (PBMC) fraction in humans. This population of granulocytes, termed low-density granulocytes (LDGs), was reported to be elevated and associated with disease activity or severity in a number of different conditions including SLE, asthma and HIV infection...
2016: PloS One
https://www.readbyqxmd.com/read/27030621/-an-analysis-of-latent-tuberculosis-infection-among-patients-with-rheumatic-diseases
#11
A F Huang, Y Luo, Y Zhao, Y Liu
OBJECTIVE: To investigate the incidence of latent tuberculosis infection (LTBI) in patients with rheumatic diseases in order to find evidence for the prevention of mycobacterium tuberculosis (MTB) in these patients. METHODS: From January 2013 to July 2015, 759 patients with rheumatic diseases and 38 health controls were enrolled. All of them underwent interferon-gamma release assays(T-SPOT.TB)to screen for LTBI. Incidence of MTB infection was evaluated in different groups and test was used for statistical analysis between groups...
April 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/26985011/concordance-between-the-tuberculin-skin-test-and-interferon-gamma-release-assay-igra-for-diagnosing-latent-tuberculosis-infection-in-patients-with-systemic-lupus-erythematosus-and-patient-characteristics-associated-with-an-indeterminate-igra
#12
H Cho, Y W Kim, C-H Suh, J-Y Jung, Y-J Um, J-H Jung, H-A Kim
OBJECTIVE: We investigated the agreement between the tuberculin skin test (TST) and the QuantiFERON-TB gold (QFT-G) assay in the diagnosis of latent tuberculosis infection (LTBI) in patients with systemic lupus erythematosus (SLE). Furthermore, we evaluated the factors associated with indeterminate results in the QFT-G assay in patients with SLE. METHODS: We enrolled 136 patients with SLE prospectively, and compared them to 66 patients with rheumatoid arthritis (RA)...
October 2016: Lupus
https://www.readbyqxmd.com/read/26951251/infection-and-lupus-which-causes-which
#13
Sarah Doaty, Harsh Agrawal, Erin Bauer, Daniel E Furst
Infection is a leading cause of morbidity and mortality among patients with systemic lupus erythematous (SLE). Dysfunction of the innate and adaptive immune systems increases the risk of infection in patients with SLE. Infectious agents have also been theorized to play a role in the pathogenesis of SLE. This article summarizes our current knowledge of the infectious risk SLE patients face as a result of their underlying disease including abnormal phagocytes and T cells as well as the increased risk of infection associated with immunosuppressive agents used to treat disease...
March 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/26950245/common-polymorphisms-in-il-27-genes-may-contribute-to-risk-of-various-human-diseases-in-asian-populations-a-meta-analysis
#14
Yun-Feng Zhang, An-Di Zhao
BACKGROUND: Genetic variations in the IL-27 gene have been proven to be associated with various types of human cancers and diseases. The purpose of the current study was to clarify the associations of the IL-27 rs153109 A>G and rs181206 T>C variants with human diseases using a meta-analysis study. MATERIAL/METHODS: A comprehensive electronic and manual search was carried out to find potential eligible studies. The effect size was represented by the unadjusted odds ratios (ORs)...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26935778/prevalence-risk-factors-management-and-treatment-outcomes-of-first-line-antituberculous-drug-induced-liver-injury-a-prospective-cohort-study
#15
Qin Sun, Qing Zhang, Jin Gu, Wen-Wen Sun, Peng Wang, Chong Bai, He-Ping Xiao, Wei Sha
PURPOSE: Antituberculosis drug-induced liver injury (ATDILI) is one of the most deleterious side effects associated with chemotherapy against tuberculosis (TB). In this study, our objective was to determine the incidence, risk factors, and management of ATDILI and analyze its impact on the treatment outcome in patients receiving standard anti-TB chemotherapy. METHODS: A prospective cohort study of ATDILI prevalence was conducted in 938 enrolled patients of the 1426 TB cases in Shanghai from March 2011 to September 2012...
August 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/26884738/spectrum-of-chronic-small-bowel-diarrhea-with-malabsorption-in-indian-subcontinent-is-the-trend-really-changing
#16
Nirav Pipaliya, Meghraj Ingle, Chetan Rathi, Prateik Poddar, Nilesh Pandav, Prabha Sawant
BACKGROUND/AIMS: This study aimed to document the recent etiological spectrum of chronic diarrhea with malabsorption and also to compare features that differentiate tropical sprue from parasitic infections, the two most common etiologies of malabsorption in the tropics. METHODS: We analyzed 203 consecutive patients with malabsorption. The etiological spectrum and factors that differentiated tropical sprue from parasitic infections were analyzed. RESULTS: The most common etiology was tropical sprue (n=98, 48...
January 2016: Intestinal Research
https://www.readbyqxmd.com/read/26870787/distinct-transcriptional-and-anti-mycobacterial-profiles-of-peripheral-blood-monocytes-dependent-on-the-ratio-of-monocytes-lymphocytes
#17
Vivek Naranbhai, Helen A Fletcher, Rachel Tanner, Matthew K O'Shea, Helen McShane, Benjamin P Fairfax, Julian C Knight, Adrian V S Hill
The ratio of monocytes and lymphocytes (ML ratio) in peripheral blood is associated with tuberculosis and malaria disease risk and cancer and cardiovascular disease outcomes. We studied anti-mycobacterial function and the transcriptome of monocytes in relation to the ML ratio. Mycobacterial growth inhibition assays of whole or sorted blood were performed and mycobacteria were enumerated by liquid culture. Transcriptomes of unstimulated CD14 + monocytes isolated by magnetic bead sorting were characterised by microarray...
November 2015: EBioMedicine
https://www.readbyqxmd.com/read/26614192/increased-risk-of-pulmonary-and-extra-pulmonary-tuberculosis-in-patients-with-rheumatic-diseases
#18
M-C Lu, C-L Lai, C-C Tsai, M Koo, N-S Lai
SETTING: Impaired immunity in patients with rheumatic diseases can increase the risk of pulmonary tuberculosis (PTB). However, it is less clear whether rheumatic diseases affect the risk of extra-pulmonary tuberculosis (EPTB). OBJECTIVE: To investigate the risk of PTB and EPTB in patients with rheumatic diseases using a population-based database. DESIGN: From Taiwan's National Health Insurance Research Database, 8536 patients with tuberculosis (TB) were frequency-matched with 42,680 controls for sex, 10-year age group and index year...
December 2015: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/26281486/neurological-manifestations-in-a-patient-of-kikuchi-s-disease
#19
Marina Vaz, Carmen M Pereira, Sindhoora Kotha, Jamina Oliveira
Kikuchi's disease is a rare condition that mainly presents in young females along with lymphadenitis. Involvement of the nervous system is rare. We report a young female who presented with fever, headache, vomiting, lymphadenopathy and neurological manifestations in the form of aseptic meningitis, ataxia and paraparesis. Since the disease can be mistaken clinically and histologically for SLE, lymphoma and tuberculosis it is important to differentiate it from these conditions. Also our case emphasizes the importance of recognising this disorder in diagnosing patients with meningitis...
November 2014: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/26275903/cohort-profile-systemic-lupus-erythematosus-in-sweden-the-swedish-lupus-linkage-slink-cohort
#20
Elizabeth V Arkema, Julia F Simard
PURPOSE: A cohort of individuals with systemic lupus erythematosus (SLE) was identified through linkage of several national registers to investigate important epidemiological questions using not only population-based data to minimise selection bias, but also to identify matched comparators from the general population to serve as controls. This cohort was established to overcome the general dearth of data in SLE epidemiology. PARTICIPANTS: All individuals registered in Sweden with a personal identity number and who have obtained medical care at any hospital or public non-primary outpatient specialist care with suspected SLE were identified...
2015: BMJ Open
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