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https://www.readbyqxmd.com/read/29050375/interstitial-fluid-pressure-of-thymic-epithelial-tumours
#1
Takeshi Mori, Wataru Nishi, Tatsuya Yamada, Yamato Motooka, Koei Ikeda, Kenji Shiraishi, Makoto Suzuki
Tumours show an increased interstitial fluid pressure, which correlates with various pathophysiological features. Moreover, interstitial fluid pressure is a prognostic factor for cervical and lung cancer. However, there have been no reports on the usefulness of measuring interstitial fluid pressure in thymic epithelial tumours. Therefore, this study aimed to examine the relationship between interstitial fluid pressure and the clinicopathological characteristics of thymic epithelial tumours. Interstitial fluid pressure was prospectively measured at the centre of the tumour using a 1-Fr Mikro-Tip sensor catheter in 44 patients with thymic epithelial tumours, 40 with thymomas and 4 with thymic carcinomas...
August 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049789/epidermal-growth-factor-receptor-mutation-status-is-strongly-associated-with-smoking-status-in-patients-undergoing-surgical-resection-for-lung-adenocarcinoma
#2
Yuki Matsumura, Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Takeo Hasegawa, Mika Hoshino, Jun Osugi, Mitsunori Higuchi, Hiroyuki Suzuki
OBJECTIVES: The purpose of this analysis was to examine the relationship between epidermal growth factor receptor (EGFR) mutation status and clinicopathological factors in a cohort of patients who underwent surgical resections for lung adenocarcinoma. METHODS: From the patients who underwent surgical resections for primary lung cancers between 2005 and 2012, 371 consecutive adenocarcinoma patients were enrolled in this study, and their tumours were analysed for EGFR mutations...
July 19, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049059/status-of-high-body-weight-among-nurse-family-partnership-children
#3
William Thorland, Dustin Currie, Claire Colangelo
PURPOSE: Increased prevalence of high levels of body weight in early childhood has become a public health concern, given its potential association with adult obesity and related comorbidities. Both socioeconomic status and race-ethnicity are related to increased prevalence. The purpose of this study was to identify additional risk factors common to children of low-income families; and to guide quality improvement initiatives within home visiting programs, potentially fostering more desirable physical development outcomes...
November 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29048988/developmental-strategy-for-a-new-group-a-meningococcalconjugate-vaccine-menafrivac-r
#4
Prasad S Kulkarni, Suresh S Jadhav, F Marc LaForce
Until recently, periodic Group A meningococcal meningitis outbreaks were a major public health problem in the sub-Saharan Africa. In 2001, the Meningitis Vaccine Project (MVP), a partnership between the World Health Organization (WHO) and PATH, a Seattle-based NGO, and the Serum Institute of India Pvt Ltd (SIIPL) initiated discussions aimed at establishing a collaborationto develop a Group A meningococcal conjugate vaccine for this unmet medical need. Over the next 8 years the partnership made countless strategic decisions about product characteristics, raw materials, potential target populations, geographic prioritization and affordability of the vaccine to name a few...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048683/long-non-coding-rna-par5-inhibits-the-proliferation-and-progression-of-glioma-through-interaction-with-ezh2
#5
Xiang-Peng Wang, Cai Shan, Xing-Li Deng, Li-Yan Li, Wei Ma
Emerging evidence suggests that long non-coding RNAs (lncRNAs) may be involved in modulating various aspects of tumor biology and serve as potential therapeutic targets as well as novel biomarkers in the treatment of glioma. The present study investigated the role of lncRNA, Prader Willi/Angelman region RNA 5 (PAR5; also known as PWAR5), in glioma and its clinical significance in glioma cases. The expression levels of PAR5 were determined in clinical samples and U87, U251 cells using real-time reverse transcription quantitative polymerase chain reaction (qRT-PCR) analysis...
September 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048646/ssrp1-silencing-inhibits-the-proliferation-and-malignancy-of-human-glioma-cells-via-the-mapk-signaling-pathway
#6
Jianming Liao, Xiang Tao, Qianshan Ding, Junhui Liu, Xue Yang, Fan-En Yuan, Ji-An Yang, Baohui Liu, Guo-An Xiang, Qianxue Chen
Structure-specific recognition protein 1 (SSRP1) has been considered as a potential biomarker, since aberrant high expression of SSRP1 has been detected in numerous malignant tumors. However, the correlation between the expression level of SSRP1 and glioma remains unclear. The present study attempted to investigate the role of SSRP1 in the pathogenesis of glioma. In the present study, our data revealed that SSRP1 overexpression was detected in glioma tissues at both the mRNA and protein levels using quantitative real-time RT-PCR and immunohistochemical analysis...
September 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048397/correlation-analysis-of-pm10-and-the-incidence-of-lung-cancer-in-nanchang-china
#7
Yi Zhou, Lianshui Li, Lei Hu
Air pollution and lung cancer are closely related. In 2013, the World Health Organization listed outdoor air pollution as carcinogenic and regarded it as the most widespread carcinogen that humans are currently exposed to. Here, grey correlation and data envelopment analysis methods are used to determine the pollution factors causing lung cancer among residents in Nanchang, China, and identify population segments which are more susceptible to air pollution. This study shows that particulate matter with particle sizes below 10 micron (PM10) is most closely related to the incidence of lung cancer among air pollution factors including annual mean concentrations of SO₂, NO₂, PM10, annual haze days, and annual mean Air Pollution Index/Air Quality Index (API/AQI)...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29048350/who-environmental-noise-guidelines-for-the-european-region-a-systematic-review-on-environmental-noise-and-adverse-birth-outcomes
#8
REVIEW
Mark J Nieuwenhuijsen, Gordana Ristovska, Payam Dadvand
Introduction: Three recent systematic reviews suggested a relationship between noise exposure and adverse birth outcomes. The aim of this review was to evaluate the evidence for the World Health Organization (WHO) noise guidelines and conduct an updated systematic review of environmental noise, specifically aircraft and road traffic noise and birth outcomes, such as preterm birth, low birth weight, being small for gestational age and congenital malformations. Materials and methods: We reviewed again all the papers on environmental noise and birth outcomes included in the previous three systematic reviews and conducted a systematic search on noise and birth outcomes to update previous reviews...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29048289/outbreak-of-zika-virus-infections-dominica-2016
#9
Sadie J Ryan, Colin J Carlson, Anna M Stewart-Ibarra, Mercy J Borbor-Cordova, Moory M Romero, Shelly-Ann Cox, Roché Mahon, Adrian Trotman, Sylvester St Ville, Shalauddin Ahmed
In February 2016, the World Health Organization declared the pandemic of Zika virus a public health emergency. On March 4, 2016, Dominica reported its first autochthonous Zika virus disease case; subsequently, 1,263 cases were reported. We describe the outbreak through November 2016, when the last known case was reported.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047418/primary-small-cell-carcinoma-of-the-breast-a-case-report
#10
Iman Abou Dalle, Jaber Abbas, Fouad Boulos, Ziad Salem, Hazem I Assi
BACKGROUND: Neuroendocrine breast cancer is a rare entity that was defined in 2003 by the World Health Organization as a separate breast cancer subtype. The diagnosis of neuroendocrine breast cancer requires the presence of neuroendocrine features in at least 50% of malignant cells, the exclusion of non-mammary primary tumors, as well as the presence of an in situ component in breast histology. The treatment and prognosis of neuroendocrine breast cancer are still not well established...
October 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29047376/women-s-education-level-amplifies-the-effects-of-a-livelihoods-based-intervention-on-household-wealth-child-diet-and-child-growth-in-rural-nepal
#11
Laurie C Miller, Neena Joshi, Mahendra Lohani, Beatrice Rogers, Shubh Mahato, Shibani Ghosh, Patrick Webb
BACKGROUND: Many organizations seek to alleviate poverty in the developing world, often focusing their interventions on women. The role, status, and education of women are fundamentally important facets of development. Thus, understanding the interaction of women's educational level and the response to interventions is important. Therefore, we examined the impact of educational level of household adults on responses to a livestock-based community intervention. METHODS: Six pair-matched communities in 3 districts of Nepal (Chitwan/Nawalparasi/Nuwakot), were randomly assigned to receive community development activities via women's self-help groups at baseline or 1 year later...
October 18, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29047083/altered-redox-balance-in-the-development-of-chronic-hypoxia-induced-pulmonary-hypertension
#12
Nikki L Jernigan, Thomas C Resta, Laura V Gonzalez Bosc
Normally, the pulmonary circulation is maintained in a low-pressure, low-resistance state with little resting tone. Pulmonary arteries are thin-walled and rely heavily on pulmonary arterial distension and recruitment for reducing pulmonary vascular resistance when cardiac output is elevated. Under pathophysiological conditions, however, active vasoconstriction and vascular remodeling lead to enhanced pulmonary vascular resistance and subsequent pulmonary hypertension (PH). Chronic hypoxia is a critical pathological factor associated with the development of PH resulting from airway obstruction (COPD, sleep apnea), diffusion impairment (interstitial lung disease), developmental lung abnormalities, or high altitude exposure (World Health Organization [WHO]; Group III)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046796/pulmonary-and-pleural-metastasis-of-intracranial-anaplastic-meningioma-in-a-3-year-old-boy-a-case-report
#13
Yuko Honda, Rie Shirayama, Hiromi Morita, Koichi Kusuhara
In adults, meningiomas occasionally display aggressive behavior and may occasionally metastasize. By contrast, pediatric meningiomas are rare, and there is limited information regarding their clinical characteristics, treatment and prognosis. We herein report the case of a 3-year-old boy with anaplastic meningioma with a history of local recurrence and late pulmonary metastasis. At diagnosis, a 70-mm mass lesion in was identified in the right frontal lobe, with intratumoral hemorrhage. The tumor was attached to the falx cerebri and was completely resected...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046715/mental-health-training-for-primary-health-care-workers-and-implication-for-success-of-integration-of-mental-health-into-primary-care-evaluation-of-effect-on-knowledge-attitude-and-practices-kap
#14
Getinet Ayano, Dawit Assefa, Kibrom Haile, Asrat Chaka, Kelemua Haile, Melat Solomon, Kalkidan Yohannis, Akilew Awoke, Kemal Jemal
BACKGROUND: Mental disorders are always remained a neglected public health problems in low and middle-income countries (LMICs), most people with mental disorders never receive effective care and there is a large treatment gap. In order to solve the problem integration of mental health into primary health care is recommended and in Ethiopia implementation of the scale of mental health services at primary health care level was started in 2014. For the success of the integration of mental health into primary health care, primary care health professionals are the key personnel who are responsible for the management of mental, neurologic and substance use disorders...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29046701/safety-of-8-weeks-oral-administration-of-arctium-lappa-l
#15
So-Hyeon Bok, Seung Sik Cho, Chun-Sik Bae, Dae-Hun Park, Kyung-Mok Park
Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient may have a history of use as a culinary material, changes in the environment over time suggest that the acceptable maximum intake each of food/culinary material should be regularly evaluated. Arctium lappa L. has been used as a culinary material for many centuries in Korea and Japan and some recent studies have reported related therapeutic effects...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046028/-aria-2016-executive-summary-integrated-care-pathways-for-predictive-medicine-throughout-the-life-cycle-in-argentina
#16
Juan Carlos Ivancevich, Hugo Neffen, Mario E Zernotti, Estrella Asayag, Ariel Blua, Alberto Cicerán, Edgardo J Jares, Alberto J Lavrut, Jorge F Máspero, Ioana Agache, Claus Bachert, Anna Bedbrook, Giorgio W Canonica, Thomas B Casale, Álvaro A Cruz, Wytske J Fokkens, Peter W Hellings, Boleslaw Samolinski, Jean Bousquet
The ARIA initiative was started during a World Health Organization workshop in 1999. The initial goals were to propose a new classification for allergic rhinitis, to promote the concept of multi-morbidity in asthma and rhinitis and to develop guidelines with stakeholders for world-wide use. ARIA is now focused on the implementation of emerging technologies for individualized and predictive medicine. MASK: MACVIA-Aria Sentinel Network uses mobile technology to develop care pathways that enable management by a multidisciplinary group or by patients themselves...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045680/report-of-a-novel-case-of-anaplastic-olfactory-groove-meningioma-and-its-methylation-subtype
#17
Aaron Song Chuan Foo, Dominic Ti Ming Tan, Char Loo Tan, Felix Sahm, Andreas von Deimling, Tseng Tsai Yeo
We report a novel case of a World Health Organization grade 3 anaplastic meningioma arising from the olfactory groove in an 83-year-old woman. Molecular and methylation profiling confirm this lesion to be an NF2 subtype, methylation class intermediate type B meningioma. As most meningiomas in this location are indolent SMO subtype lesions, our report suggests that even though rare, aggressive NF2 subtype meningiomas can also occur along the midline anterior skull base.
October 16, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29045604/increases-in-neisseria-gonorrhoeae-with-reduced-susceptibility-to-azithromycin-among-men-who-have-sex-with-men-msm-in-seattle-king-county-washington-2012-2016
#18
Lindley A Barbee, Olusegun O Soge, David A Katz, Julia C Dombrowski, King K Holmes, Matthew R Golden
Background: Antimicrobial-resistant Neisseria gonorrhea is a major public health threat. The CDC recommends that clinicians treat gonorrhea with ceftriaxone 250mg plus azithromycin 1g. Resistance to azithromycin could affect gonorrhea control efforts. Methods: We evaluated antimicrobial susceptibility profiles and clinical data of gonococcal isolates collected at the Public Health-Seattle & King County (PHSKC) STD Clinic from 2012-2016, focusing on 2014-2016. We compared cases with CDC azithromycin (AZM) alert value MIC (MIC ≥2 µg/mL) to those with AZM MIC ≤1 µg/mL, and evaluated clinical outcomes...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29045267/the-prevalence-and-investigation-of-risk-factors-of-oral-mucositis-in-a-pediatric-oncology-inpatient-population-a-prospective-study
#19
Gabrielle Allen, Richard Logan, Tom Revesz, Dorothy Keefe, Sam Gue
BACKGROUND: Oral mucositis can be a frequent and severe complication of chemotherapy in children. It can result in pain, infection, depression, prolonged admission, treatment delays, increase in patient morbidity, and increased costs. AIM: To record the prevalence and severity of oral mucositis among inpatients and explore the relationship of risks factors and the development of oral mucositis. DESIGN: During an 18-month period 643 clinical inpatient assessments were completed on 73 children who were admitted and had received chemotherapy in the last 14 days...
October 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29044913/assessment-of-cytologic-differentiation-in-high-grade-pancreatic-neuroendocrine-neoplasms-a-multi-institutional-study
#20
Carlie S Sigel, Vitor Werneck Krauss Silva, Michelle D Reid, David Chhieng, Olca Basturk, Keith M Sigel, Tanisha D Daniel, David S Klimstra, Laura H Tang
BACKGROUND: Well-differentiated (WD) and poorly differentiated (PD) pancreatic neuroendocrine neoplasms are biologically distinct entities with different therapies and prognoses. WD neoplasms with elevated proliferation (Ki-67 > 20%) have been shown to have an overlapping histology with PD neuroendocrine carcinomas. This study compared expert cytomorphologic assessments of differentiation in pancreatic neuroendocrine neoplasms in a multi-institutional study. METHODS: Fine-needle aspiration specimens from pancreatic neuroendocrine neoplasms (grade 2 [G2] and grade 3 [G3] according to the 2017 World Health Organization classification; n = 72) were diagnosed independently by 3 cytopathologists as WD or PD (poorly differentiated large cell type [PD-L] or poorly differentiated small cell type [PD-S]) purely on the basis of cytomorphology...
October 17, 2017: Cancer
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