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https://www.readbyqxmd.com/read/29667574/genomic-non-coding-regions-reveal-hidden-patterns-of-mumps-virus-circulation-in-spain-2005-to-2015
#1
Ana M Gavilán, Aurora Fernández-García, Angel Rueda, Ana Castellanos, Josefa Masa-Calles, Noemí López-Perea, María V Torres de Mier, Fernando de Ory, Juan E Echevarría
BackgroundSince mumps vaccination was introduced in 1981 in Spain, the incidence of the disease has dropped significantly. However, cyclic epidemic waves and outbreaks still occur, despite high vaccination coverage. The World Health Organization (WHO) recommends genotyping to trace the pattern of mumps virus (MuV) circulation. Genotype H was predominant in Spain, but was replaced in 2005 by genotype G which has subsequently remained dominant. Of the small hydrophobic protein gene sequences, 78% are identical and belong to the MuVi/ Sheffield...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29667175/first-line-drugs-for-hypertension
#2
REVIEW
James M Wright, Vijaya M Musini, Rupam Gill
BACKGROUND: This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that question. OBJECTIVES: To quantify the mortality and morbidity effects from different first-line antihypertensive drug classes: thiazides (low-dose and high-dose), beta-blockers, calcium channel blockers, ACE inhibitors, angiotensin II receptor blockers (ARB), and alpha-blockers, compared to placebo or no treatment...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29667086/contrast-enhancement-predicting-survival-in-integrated-molecular-subtypes-of-diffuse-glioma-an-observational-cohort-study
#3
Johann-Martin Hempel, Cornelia Brendle, Benjamin Bender, Georg Bier, Marco Skardelly, Irina Gepfner-Tuma, Franziska Eckert, Ulrike Ernemann, Jens Schittenhelm
INTRODUCTION: To assess the predictive value of magnetic resonance imaging (MRI) gadolinium enhancement as a prognostic factor in the 2016 World Health Organization Classification of Tumors of the Central Nervous System integrated glioma groups. METHODS: Four-hundred fifty patients with histopathologically confirmed glioma were retrospectively assessed between 07/1997 and 06/2014 using gadolinium enhancement, survival, and relevant prognostic molecular data [isocitrate dehydrogenase (IDH); alpha-thalassemia/mental retardation syndrome X-linked (ATRX); chromosome 1p/19q loss of heterozygosity; and O6-methylguanine DNA methyltransferase (MGMT)]...
April 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29666797/development-and-implementation-of-a-perianesthetic-safety-checklist-in-a-veterinary-university-small-animal-teaching-hospital
#4
Gwennaëlle Menoud, Shannon Axiak Flammer, Claudia Spadavecchia, Mathieu Raillard
Introduction: The use of a surgical safety checklist is recommended by the World Health Organization and is associated with advantages: improved communication and reduced complications and mortality. Adapting checklists to the environment in which they are used improves their efficiency, but their implementation can be challenging. The aim of this study was to develop and implement a perianesthetic safety checklist for a small animal hospital. Materials and methods: A panel of eight anesthesia diplomates and seven residents and doctoral students were gathered...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29666681/implications-of-early-pregnancy-obesity-on-maternal-fetal-and-neonatal-health-retrospective-cohort-study-from-oman
#5
Anita Zutshi, Jayasree Santhosh, Julie Sheikh, Fareeha Naeem, Ahmed Al-Hamedi, Shahla Khan, Eishthiag Al-Said
Objectives: This study aimed to determine the prevalence of early pregnancy obesity among Omani women and to review maternal antenatal complications, intrapartum and postpartum events and neonatal complications among such women in comparison to women of normal weight. Methods: This retrospective cohort study included 2,652 pregnant Omani women who delivered at the Royal Hospital, Muscat, Oman, between November 2011 and April 2012. The patients' electronic medical records were reviewed for antenatal, intrapartum and postpartum data...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29665947/the-burden-of-multidrug-resistant-tuberculosis-in-children
#6
H E Jenkins, C M Yuen
BACKGROUND: Childhood tuberculosis (TB) has historically been neglected, although in recent years there has been increased focus on this problem. In particular, there have been two efforts to estimate the burden of pediatric multidrug-resistant TB (MDR-TB). METHODS: We review current estimates of the global incidence of pediatric MDR-TB disease. We then combine pediatric MDR-TB treatment data from the World Health Organization and recently published case fatality ratio estimates for children with TB to produce mortality estimates for children with MDR-TB...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29665751/residential-mobility-and-cognitive-function-among-middle-aged-and-older-adults-in-china
#7
Hanzhang Xu, Matthew E Dupre, Truls Østbye, Allison A Vorderstrasse, Bei Wu
OBJECTIVES: To assess the association between rural and urban residential mobility and cognitive function among middle-aged and older adults in China. METHOD: We used data from the World Health Organization Study on global AGEing and adult health that included adults age 50+ from China ( N = 12,410). We used multivariate linear regressions to examine how residential mobility and age at migration were associated with cognitive function. RESULTS: Urban and urban-to-urban residents had the highest level of cognitive function, whereas rural and rural-to-rural residents had the poorest cognitive function...
January 1, 2018: Research on Aging
https://www.readbyqxmd.com/read/29665736/fear-avoidance-and-clinical-outcomes-from-mild-traumatic-brain-injury
#8
Noah D Silverberg, William Panenka, Grant L Iverson
Characterizing psychological factors that contribute to persistent symptoms after mild traumatic brain injury (MTBI) can inform early intervention. To determine whether fear avoidance, a known risk factor for chronic disability after musculoskeletal injury, is associated with worse clinical outcomes from MTBI, adults were recruited from four outpatient MTBI clinics and assessed at their first clinic visit (M=2.7, SD=1.5 weeks post-injury) and again 4-5 months later. Of 273 patients screened, 102 completed the initial assessment and 87 returned for the outcome assessment...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29665678/lectin-functionalized-composite-hydrogels-for-capture-and-killing-of-carbapenem-resistant-pseudomonas-aeruginosa
#9
Nicholas Bodenberger, Dennis Kubiczek, Daniel Halbgebauer, Vittoria Rimola, Sebastian Wiese, Daniel Mayer, Armando Alexei Rodr Iacute Guez Alfonso, Ludger Ständker, Steffen Stenger, Frank Rosenau
Infections with multi-resistant pathogens are a leading cause for mortality worldwide. Just recently, the world health organization (WHO) increased the threat rating for multi-resistant Pseudomonas aeruginosa to the highest possible level. With this background it is crucial to develop novel materials and procedures in the fight against multi-resistant pathogens. In this study we present a novel antimicrobial material, which could find applications as a wound dressing or antimicrobial coating. Lectins are multivalent sugar-binding proteins, which can be found in a variety of plants and bacteria, where they are associated with biofilm formation...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29665657/recent-advances-in-the-diagnosis-and-management-of-primary-myelofibrosis
#10
Katsuto Takenaka, Kazuya Shimoda, Koichi Akashi
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways is the major pathogenic mechanism. Most patients with PMF carry a driver mutation in the JAK2, MPL (myeloproliferative leukemia), or CALR (calreticulin) genes. Mutations in epigenetic regulators and RNA splicing genes may also occur, and play critical roles in PMF disease progression. Based on revised World Health Organization diagnostic criteria for MPNs, both screening for driver mutations and bone marrow biopsy are required for a specific diagnosis...
April 20, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29665634/characterization-of-microplastic-litter-in-the-gastrointestinal-tract-of-solea-solea-from-the-adriatic-sea
#11
G Pellini, A Gomiero, T Fortibuoni, Carmen Ferrà, F Grati, A N Tassetti, P Polidori, G Fabi, G Scarcella
Micro-plastic particles in the world's oceans represent a serious threat to both human health and marine ecosystems. Once released into the aquatic environment plastic litter is broken down to smaller pieces through photo-degradation and the physical actions of waves, wind, etc. The resulting particles may become so small that they are readily taken up by fish, crustaceans and mollusks. There is mounting evidence for the uptake of plastic particles by marine organisms that form part of the human food chain and this is driving urgent calls for further and deeper investigations into this pollution issue...
March 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29665617/transradial-versus-transfemoral-approach-for-diagnostic-coronary-angiography-and-percutaneous-coronary-intervention-in-people-with-coronary-artery-disease
#12
REVIEW
Ahmed A Kolkailah, Rabah S Alreshq, Ahmed M Muhammed, Mohamed E Zahran, Marwah Anas El-Wegoud, Ashraf F Nabhan
BACKGROUND: Cardiovascular disease (CVD) is the major cause of mortality worldwide. Coronary artery disease (CAD) contributes to half of mortalities caused by CVD. The mainstay of management of CAD is medical therapy and revascularisation. Revascularisation can be achieved via coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Peripheral arteries, such as the femoral or radial artery, provide the access to the coronary arteries to perform diagnostic or therapeutic (or both) procedures...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29665516/-cool-and-hot-executive-functions-in-suicide-attempters-with-major-depressive-disorder
#13
Ming-Chou Ho, Yi-Chieh Hsu, Mong-Liang Lu, Michael Gossop, Vincent Chin-Hung Chen
RATIONALE: The World Health Organization reports that, by 2030, depression is expected to be the largest contributor to disease burden. Only small proportion of patients with major depressive disorder (MDD) achieves remission and the majority of them do not achieve long-term functional recovery. One of the neuropsychological domains that have been shown to be particularly impaired in depression, is that of executive function (EF). OBJECTIVES: We examined whether the patients with MDD with and without suicide attempts had deteriorated 'cool' EF and 'hot' EF...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29665163/lowered-quality-of-life-in-mood-disorders-is-associated-with-increased-neuro-oxidative-stress-and-basal-thyroid-stimulating-hormone-levels-and-use-of-anticonvulsant-mood-stabilizers
#14
Caroline Sampaio Nunes, Michael Maes, Chutima Roomruangwong, Juliana Brum Moraes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Decio Sabbatini Barbosa, George Anderson, Luiz Gustavo Piccoli de Melo, Stoyanov Drozdstoj, Estefania Moreira, André F Carvalho, Sandra Odebrecht Vargas Nunes
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29665038/safety-and-feasibility-of-outpatient-rabbit-antithymocyte-globulin-induction-therapy-administration-in-kidney-transplant-recipients
#15
Alexandra N Varga, David Johnson, Deirdre L Sawinski, Mary Ann Lim, Roy D Bloom, Peter L Abt, Simin Goral, Melissa Bleicher, Matthew H Levine, Ali Naji, Susanna Nazarian, Paige Porrett, Jennifer Trofe-Clark
BACKGROUND: Kidney transplant induction therapy often includes inpatient administration of rabbit antithymocyte globulin (rATG) over multiple days. To reduce hospital length of stay (LOS) and drug expenditures, the rATG induction course was completed in the outpatient setting via peripheral intravenous administration. The present study assesses early readmission trends ascribable to an outpatient rATG administration protocol to assure initial reduction in hospital LOS is sustained early after discharge...
April 17, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29664951/universal-versus-conditional-day-3-follow-up-for-children-with-non-severe-unclassified-fever-at-the-community-level-in-the-democratic-republic-of-the-congo-a-cluster-randomized-community-based-non-inferiority-trial
#16
Luke C Mullany, Elburg W van Boetzelaer, Julie R Gutman, Laura C Steinhardt, Pascal Ngoy, Yolanda Barbera Lainez, Alison Wittcoff, Steven A Harvey, Lara S Ho
BACKGROUND: The World Health Organization's integrated community case management (iCCM) guidelines recommend that all children presenting with uncomplicated fever and no danger signs return for follow-up on day 3 following the initial consultation on day 1. Such fevers often resolve rapidly, however, and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aimed to determine if a conditional follow-up visit was non-inferior to a universal follow-up visit for these children...
April 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29664159/reading-aids-for-adults-with-low-vision
#17
REVIEW
Gianni Virgili, Ruthy Acosta, Sharon A Bentley, Giovanni Giacomelli, Claire Allcock, Jennifer R Evans
BACKGROUND: The purpose of low-vision rehabilitation is to allow people to resume or to continue to perform daily living tasks, with reading being one of the most important. This is achieved by providing appropriate optical devices and special training in the use of residual-vision and low-vision aids, which range from simple optical magnifiers to high-magnification video magnifiers. OBJECTIVES: To assess the effects of different visual reading aids for adults with low vision...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29663964/the-challenge-of-estimating-tuberculosis-mortality-accurately-in-england-and-wales
#18
M K Lalor, T Mohiyuddin, T Uddin, H L Thomas, M Lipman, C N J Campbell
BACKGROUND: Accurate estimates of tuberculosis (TB) mortality are required to monitor progress towards the World Health Organization End TB goal of reducing TB deaths by 95% by 2035. We compared TB death data for England and Wales from the national surveillance system (Enhanced Tuberculosis Surveillance System [ETS]) and the vital registration system from the Office for National Statistics (ONS). METHODS: TB cases notified in ETS were matched to deaths in ONS (dONS) with International Classification of Diseases, Tenth Revision (ICD-10) codes indicating that TB caused/contributed to the death (A15-A19)...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663960/impact-of-pyrazinamide-resistance-on-multidrug-resistant-tuberculosis-in-karakalpakstan-uzbekistan
#19
J Kuhlin, C Smith, A Khaemraev, Z Tigay, N Parpieva, M Tillyashaykhov, J Achar, J Hajek, J Greig, P du Cros, D Moore
SETTING: The World Health Organization (WHO) recommends the inclusion of pyrazinamide (PZA) in treatment regimens for multidrug-resistant tuberculosis (MDR-TB) unless resistance has been confirmed. OBJECTIVE: To investigate the association between PZA susceptibility and MDR-TB treatment outcome among patients treated with a PZA-containing regimen and whether the duration of the intensive phase of the PZA-containing regimen affected treatment outcome. DESIGN: We conducted a retrospective cohort study including all eligible MDR-TB patients starting treatment in 2003-2013 in the TB programme in Karakalpakstan, Uzbekistan...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663705/bronchial-brush-cytology-of-primary-anaplastic-large-cell-lymphoma-of-lung
#20
Meyyappa Devan Rajagopal, Debasis Gochhait, Bheemanathi Hanuman Srinivas, Rajesh Nachiappa Ganesh, Neelaiah Siddaraju, Manju Rajaram
Primary pulmonary lymphoma is defined as clonal lymphoid proliferation affecting one or both lungs in a patient with no extrapulmonary involvement at the time of diagnosis or during the subsequent 3 months. Anaplastic large cell lymphoma (ALCL) is a rare T-cell neoplasm which occurs as two distinct clinical entities-cutaneous and systemic variant. Primary lung involvement is extremely uncommon. It can be classified on the basis of being positive or negative for ALK rearrangement which carries prognostic significance...
April 16, 2018: Diagnostic Cytopathology
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