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JOURNAL ARTICLE
Tomoko Ikeuchi, Ramin Akhi, Belmaliz Cardona Rodriguez, David Fraser, Drake Williams, Kim Tae Sung, Teresa Greenwell-Wild, Andrew Overmiller, Maria Morasso, Niki Moutsopoulos
Single-cell RNA sequencing and flow cytometry approaches have been instrumental in understanding cellular states within various tissues and organs. However, tissue dissociation methods can potentially alter results and create bias due to preferential recovery of particular cell types. Here we present efforts to optimize methods for dissociation of murine oral mucosal tissues and provide three different protocols that can be utilized to isolate major cell populations in the oral mucosa. These methods can be used both in health and in states of inflammation, such as periodontitis...
December 22, 2023: Journal of Immunological Methods
#22
JOURNAL ARTICLE
Dana D Im, Alice K Bukhman, Josh W Joseph, Jim C Dziobek, Jill Grant, Kathleen C Clifford, Inkyu Kim, Paul C Chen, Naomi A Schmelzer, Robin Powell, Beth Waters, Andrew Dundin, Noah Askman, Terrance Lassiter, Da'Marcus E Baymon, Kalpana Shankar, Leon D Sanchez
INTRODUCTION: Restraint use in the emergency department (ED) can pose significant risks to patients and health care workers. We evaluate the effectiveness of Code De-escalation- a standardized, team-based approach for management and assessment of threatening behaviors- in reducing physical restraint use and workplace violence in a community ED. METHODS: A retrospective observational study of a pathway on physical restraint use among patients placed on an involuntary psychiatric hold in a community ED...
December 3, 2023: American Journal of Emergency Medicine
#23
JOURNAL ARTICLE
Hyunkyung Yun, Jin Kim, Aishwarya Gandhe, Brianna Nelson, Jim C Hu, Vikas Gulani, Daniel Margolis, Bruce R Schackman, Ali Jalali
IMPORTANCE: Magnetic resonance imaging (MRI) and potential MRI-guided biopsy enable enhanced identification of clinically significant prostate cancer. Despite proven efficacy, MRI and potential MRI-guided biopsy remain costly, and there is limited evidence regarding the cost-effectiveness of this approach in general and for different prostate-specific antigen (PSA) strata. OBJECTIVE: To examine the cost-effectiveness of integrating annual MRI and potential MRI-guided biopsy as part of clinical decision-making for men after being screened for prostate cancer compared with standard biopsy...
November 1, 2023: JAMA Network Open
#24
JOURNAL ARTICLE
Laura Warren, Brett G Fischer, Amos Shemesh, Jean Scofi, Nekee Pandya, Robert J Kim, Caroline Andy, Sophie Rand, Jim Yee, Stacia Semple, Amy Chadburn, He S Yang, Peter A D Steel, Zhen Zhao
BACKGROUND: Guidelines recommend high-sensitivity cardiac troponin (hs-cTn) for diagnosis of myocardial infarction. Use of hs-cTn is increasing across the U.S., but questions remain regarding clinical and operational impact. Prior studies have had methodologic limitations and yielded conflicting results. OBJECTIVE: To evaluate the impact of transitioning from conventional cardiac troponin (cTn) to hs-cTn on test and resource utilization, operational efficiency, and patient safety...
November 22, 2023: Journal of General Internal Medicine
#25
JOURNAL ARTICLE
Ji-Min Lee, Keunbada Son, Jim-Wook Kim, Myoung-Uk Jin, Kyu-Bok Lee
PURPOSE: This study aimed to evaluate the effects of an ergonomic dentist stool design on muscle activity and fatigue in dentists. MATERIALS AND METHODS: Fourteen dentists were recruited, and electrodes were attached to the arm, neck, and shoulder muscles of these dentists according to the Surface ElectroMyoGraphy for the Non-Invasive Assessment of Muscles protocol. After measuring the maximal voluntary contraction, eight-channel surface electromyography was performed during simulations of two dental procedures (intraoral scanning and tooth preparation) while the dentists were using two types of dentist stools...
November 21, 2023: International Journal of Prosthodontics
#26
Erratum for: Lung Abnormalities Detected with Hyperpolarized 129 Xe MRI in Patients with Long COVID.
James T Grist, Guilhem J Collier, Huw Walters, Minsuok Kim, Mitchell Chen, Gabriele Abu Eid, Aviana Laws, Violet Matthews, Kenneth Jacob, Susan Cross, Alexandra Eves, Marianne Durrant, Anthony McIntyre, Roger Thompson, Rolf F Schulte, Betty Raman, Peter A Robbins, Jim M Wild, Emily Fraser, Fergus Gleeson
No abstract text is available yet for this article.
October 2023: Radiology
#27
JOURNAL ARTICLE
Brian R Lee, Rachel Dalley, Jeremy A Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, Lindsay Ng, Lauren Alfiler, Katherine Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Eva Csajbok, Nicholas Donadio, Stan L W Driessens, Tom Egdorf, Rachel Enstrom, Anna A Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S Heistek, Dijon Hill, Wen-Hsien Hou, Nelson Johansen, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela León, Brian Long, Matthew Mallory, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica J Melief, Gabor Molnar, Marty T Mortrud, Dakota Newman, Julie Nyhus, Ximena Opitz-Araya, Attila Ozsvár, Trangthanh Pham, Alice Pom, Lydia Potekhina, Ram Rajanbabu, Augustin Ruiz, Susan M Sunkin, Ildikó Szöts, Naz Taskin, Bargavi Thyagarajan, Michael Tieu, Jessica Trinh, Sara Vargas, David Vumbaco, Femke Waleboer, Sarah Walling-Bell, Natalie Weed, Grace Williams, Julia Wilson, Shenqin Yao, Thomas Zhou, Pál Barzó, Trygve Bakken, Charles Cobbs, Nick Dee, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W Gouwens, Benjamin Grannan, Ryder P Gwinn, Jason S Hauptman, Rebecca Hodge, Tim Jarsky, C Dirk Keene, Andrew L Ko, Anders Rosendal Korshoej, Boaz P Levi, Kaare Meier, Jeffrey G Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L Silbergeld, Kimberly Smith, Jens Christian Sørensen, Jack Waters, Hongkui Zeng, Jim Berg, Marco Capogna, Natalia A Goriounova, Brian Kalmbach, Christiaan P J de Kock, Huib D Mansvelder, Staci A Sorensen, Gabor Tamas, Ed S Lein, Jonathan T Ting
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq (patch-clamp electrophysiology plus single-cell RNA sequencing) sampling in human brain slices was used to reliably target and analyze GABAergic neuron subclasses and individual transcriptomic types. This characterization elucidated transitions between PVALB and SST subclasses, revealed morphological heterogeneity within an abundant transcriptomic type, identified multiple spatially distinct types of the primate-specialized double bouquet cells (DBCs), and shed light on cellular differences between homologous mouse and human neocortical GABAergic neuron types...
October 13, 2023: Science
#28
JOURNAL ARTICLE
Thomas Chartrand, Rachel Dalley, Jennie Close, Natalia A Goriounova, Brian R Lee, Rusty Mann, Jeremy A Miller, Gabor Molnar, Alice Mukora, Lauren Alfiler, Katherine Baker, Trygve E Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, Krissy Brouner, Tamara Casper, Eva Adrienn Csajbok, Nick Dee, Tom Egdorf, Rachel Enstrom, Anna A Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S Heistek, DiJon Hill, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela Leon, Brian Long, Matthew Mallory, Medea McGraw, Delissa McMillen, Erica J Melief, Norbert Mihut, Lindsay Ng, Julie Nyhus, Gáspár Oláh, Attila Ozsvár, Victoria Omstead, Zoltan Peterfi, Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Marton Rozsa, Augustin Ruiz, Joanna Sandle, Susan M Sunkin, Ildiko Szots, Michael Tieu, Martin Toth, Jessica Trinh, Sara Vargas, David Vumbaco, Grace Williams, Julia Wilson, Zizhen Yao, Pal Barzo, Charles Cobbs, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W Gouwens, Benjamin Grannan, Ryder P Gwinn, Jason S Hauptman, Tim Jarsky, C Dirk Keene, Andrew L Ko, Christof Koch, Jeffrey G Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L Silbergeld, Kimberly Smith, Staci A Sorensen, Bosiljka Tasic, Jonathan T Ting, Jack Waters, Christiaan P J de Kock, Huib D Mansvelder, Gabor Tamas, Hongkui Zeng, Brian Kalmbach, Ed S Lein
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1...
October 13, 2023: Science
#29
JOURNAL ARTICLE
Rongxu Xu, Bong Wan Kim, Sa Jim Soe Moe, Anam Nawaz Khan, Kwangsoo Kim, Do Hyeun Kim
Construction sites remain highly perilous work environments globally, exposing employees to numerous hazards that can result in severe injuries or fatalities. To resolve this several solutions based on quantitative approaches have been developed. However the wide adoption of preexisting solutions is hindered by lack of accuracy. To this aim the development of an efficient fuzzy inference system has become a de-facto necessity. In this paper, we propose an edge inference framework based on multi-layered fuzzy logic for safety of construction workers...
September 2023: Heliyon
#30
JOURNAL ARTICLE
Phyllis Lau, Minh Thuan Tran, Ricky Yong Kim, Alsayed Hashem Alrefae, Sangwoo Ryu, Jim Chyuan Teh
BACKGROUND: Electronic prescription (e-prescription) was introduced in 2020 in Australia during the COVID-19 pandemic. This research aimed to explore general practitioners (GPs) and community pharmacists' experience with, and facilitators and barriers to, the use of e-prescription. METHODS: This qualitative study used semi-structured interviews with GPs and pharmacists in Greater Sydney to explore their experience with e-prescription. Thematic analysis used descriptive and mixed inductive and deductive approaches...
February 2024: Australian Journal of Primary Health
#31
JOURNAL ARTICLE
Nicola de'Angelis, Carlo Alberto Schena, Francesco Marchegiani, Elisa Reitano, Belinda De Simone, Geoffrey Yuet Mun Wong, Aleix Martínez-Pérez, Fikri M Abu-Zidan, Vanni Agnoletti, Filippo Aisoni, Michele Ammendola, Luca Ansaloni, Miklosh Bala, Walter Biffl, Graziano Ceccarelli, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Stefania Cimbanassi, Federico Coccolini, Raul Coimbra, Salomone Di Saverio, Michele Diana, Marco Dioguardi Burgio, Gustavo Fraga, Paschalis Gavriilidis, Angela Gurrado, Riccardo Inchingolo, Alexandre Ingels, Rao Ivatury, Jeffry L Kashuk, Jim Khan, Andrew W Kirkpatrick, Fernando J Kim, Yoram Kluger, Zaher Lakkis, Ari Leppäniemi, Ronald V Maier, Riccardo Memeo, Ernest E Moore, Carlos A Ordoñez, Andrew B Peitzman, Gianluca Pellino, Edoardo Picetti, Manos Pikoulis, Michele Pisano, Mauro Podda, Oreste Romeo, Fausto Rosa, Edward Tan, Richard P Ten Broek, Mario Testini, Brian Anthony Tian Wei Cheng, Dieter Weber, Emilio Sacco, Massimo Sartelli, Alfredo Tonsi, Fabrizio Dal Moro, Fausto Catena
Iatrogenic urinary tract injury (IUTI) is a severe complication of emergency digestive surgery. It can lead to increased postoperative morbidity and mortality and have a long-term impact on the quality of life. The reported incidence of IUTIs varies greatly among the studies, ranging from 0.3 to 1.5%. Given the high volume of emergency digestive surgery performed worldwide, there is a need for well-defined and effective strategies to prevent and manage IUTIs. Currently, there is a lack of consensus regarding the prevention, detection, and management of IUTIs in the emergency setting...
September 9, 2023: World Journal of Emergency Surgery: WJES
#32
JOURNAL ARTICLE
Ying Chen, Siqun Zhou, Komal Pradhan, Natalia Chernyak, Esther Kofman, Fan Zhang, Sang Yeop Kim, Wolfgang Seghezzi, Aarron Willingham, W Michael Seganish, Bhagyashree Bhagwat, Jin-Hwan Han
Targeted immune agonist (TIA) comprising a TLR7 agonist conjugated to tumor-targeting antibodies have been shown to induce potent anti-tumor responses in various preclinical models. However, the clinical proof-of-concept of a TIA has been hampered by systemic dose-limiting immune-related toxicities, including rapid induction of anti-drug antibodies in patients. We have developed ELISPOT-based assay to measure activation of antibody-secreting cells (ASCs), intended to simulate the interaction between TIA and peripheral B cells as a tool to pre-clinically de-risk tumor target-independent peripheral B-cell activation by TIA...
September 1, 2023: Journal of Immunological Methods
#33
JOURNAL ARTICLE
Diala Steitieh, Rebecca Klahr, Adam Greenfest, Shirley Xu, Jim W Cheung, Dmitriy N Feldman, Harsimran S Singh, Robert M Minutello, S Chiu Wong, Joseph Wang, Daniel Y Lu, Maria G Karas, Luke K Kim
A subset of patients with myocarditis present with cardiogenic shock. There is a lack of contemporary data assessing the use of mechanical circulatory support (MCS) in these patients. Myocarditis hospitalizations were analyzed using the National Inpatient Sample between 2016 and 2019. Characteristics of patients with and without cardiogenic shock were assessed. Trends in mortality, MCS, right-sided cardiac catheterization (RHC) and endomyocardial biopsy were evaluated. The impact of RHC on consequent MCS and mortality was studied...
August 31, 2023: American Journal of Cardiology
#34
REVIEW
Jin Sung Son, Ryan Chow, Helena Kim, Toney Lieu, Maria Xiao, Sunny Kim, Kathy Matuszewska, Madison Pereira, David Le Nguyen, Jim Petrik
OBJECTIVE: To systematically identify and narratively synthesize the evidence surrounding liposomal delivery of gene therapy and the outcome for ovarian cancer. METHODS: An electronic database search of the Embase, MEDLINE and Web of Science from inception until July 7, 2023, was conducted to identify primary studies that investigated the effect of liposomal delivery of gene therapy on ovarian cancer outcomes. Retrieved studies were assessed against the eligibility criteria for inclusion...
August 23, 2023: Reproductive Biology and Endocrinology: RB&E
#35
JOURNAL ARTICLE
Suchen Kumar Yadav, Seokwoo Park, Yun-Mi Lee, Sunghoon Hurh, Dongsuk Kim, Sangil Min, Sejoong Kim, Ji-Jing Yan, Byeong-Cheol Kang, Sungjoo Kim, Jaeseok Yang, Jong Cheol Jeong
Transplantation of organs, cells, or tissues from one species to another, known as xenotransplantation, has the potential to alleviate organ donor shortages and enhance the success of organ transplantation. However, the possibility of immunological rejection by the recipient is one of the biggest difficulties associated with xenotransplantation. The creation of neutrophil extracellular traps (NETs), also known as NETosis, is hypothesized as a mechanism of rejection. Innovations in microfluidics and co-culturing techniques have provided access to several classes of microengineered model systems in experimental models, connecting animal research and traditional in vitro methods such as organoids, microphysiological systems, and organs-on-chip...
August 18, 2023: Journal of Immunological Methods
#36
JOURNAL ARTICLE
Jin-Gyu Cheong, Arjun Ravishankar, Siddhartha Sharma, Christopher N Parkhurst, Simon A Grassmann, Claire K Wingert, Paoline Laurent, Sai Ma, Lucinda Paddock, Isabella C Miranda, Emin Onur Karakaslar, Djamel Nehar-Belaid, Asa Thibodeau, Michael J Bale, Vinay K Kartha, Jim K Yee, Minh Y Mays, Chenyang Jiang, Andrew W Daman, Alexia Martinez de Paz, Dughan Ahimovic, Victor Ramos, Alexander Lercher, Erik Nielsen, Sergio Alvarez-Mulett, Ling Zheng, Andrew Earl, Alisha Yallowitz, Lexi Robbins, Elyse LaFond, Karissa L Weidman, Sabrina Racine-Brzostek, He S Yang, David R Price, Louise Leyre, André F Rendeiro, Hiranmayi Ravichandran, Junbum Kim, Alain C Borczuk, Charles M Rice, R Brad Jones, Edward J Schenck, Robert J Kaner, Amy Chadburn, Zhen Zhao, Virginia Pascual, Olivier Elemento, Robert E Schwartz, Jason D Buenrostro, Rachel E Niec, Franck J Barrat, Lindsay Lief, Joseph C Sun, Duygu Ucar, Steven Z Josefowicz
Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. We found that circulating HSPC, enriched from peripheral blood, captured the diversity of bone marrow HSPC, enabling investigation of their epigenomic reprogramming following coronavirus disease 2019 (COVID-19). Alterations in innate immune phenotypes and epigenetic programs of HSPC persisted for months to 1 year following severe COVID-19 and were associated with distinct transcription factor (TF) activities, altered regulation of inflammatory programs, and durable increases in myelopoiesis...
August 31, 2023: Cell
#37
JOURNAL ARTICLE
Christopher J Schulze, Kyle J Seamon, Yulei Zhao, Yu C Yang, Jim Cregg, Dongsung Kim, Aidan Tomlinson, Tiffany J Choy, Zhican Wang, Ben Sang, Yasin Pourfarjam, Jessica Lucas, Antonio Cuevas-Navarro, Carlos Ayala-Santos, Alberto Vides, Chuanchuan Li, Abby Marquez, Mengqi Zhong, Vidyasiri Vemulapalli, Caroline Weller, Andrea Gould, Daniel M Whalen, Anthony Salvador, Anthony Milin, Mae Saldajeno-Concar, Nuntana Dinglasan, Anqi Chen, Jim Evans, John E Knox, Elena S Koltun, Mallika Singh, Robert Nichols, David Wildes, Adrian L Gill, Jacqueline A M Smith, Piro Lito
The discovery of small-molecule inhibitors requires suitable binding pockets on protein surfaces. Proteins that lack this feature are considered undruggable and require innovative strategies for therapeutic targeting. KRAS is the most frequently activated oncogene in cancer, and the active state of mutant KRAS is such a recalcitrant target. We designed a natural product-inspired small molecule that remodels the surface of cyclophilin A (CYPA) to create a neomorphic interface with high affinity and selectivity for the active state of KRASG12C (in which glycine-12 is mutated to cysteine)...
August 18, 2023: Science
#38
JOURNAL ARTICLE
Guglielmo Niccolò Piozzi, Krunal Khobragade, Vusal Aliyev, Oktar Asoglu, Paolo Pietro Bianchi, Vlad-Olimpiu Butiurca, William Tzu-Liang Chen, Ju Yong Cheong, Gyu-Seog Choi, Andrea Coratti, Quentin Denost, Yosuke Fukunaga, Emre Gorgun, Francesco Guerra, Masaaki Ito, Jim S Khan, Hye Jin Kim, Jin Cheon Kim, Yusuke Kinugasa, Tsuyoshi Konishi, Li-Jen Kuo, Mehmet Ayhan Kuzu, Jeremie H Lefevre, Jin-Tung Liang, John Marks, Călin Molnar, Yves Panis, Philippe Rouanet, Eric Rullier, Avanish Saklani, Antonino Spinelli, Petr Tsarkov, Shunsuke Tsukamoto, Martin Weiser, Seon Hahn Kim
AIM: Intersphincteric resection (ISR) is an oncologically complex operation for very low-lying rectal cancers. Yet, definition, anatomical description, operative indications and operative approaches to ISR are not standardized. The aim of this study was to standardize the definition of ISR by reaching international consensus from the experts in the field. This standardization will allow meaningful comparison in the literature in the future. METHOD: A modified Delphi approach with three rounds of questionnaire was adopted...
September 2023: Colorectal Disease
#39
JOURNAL ARTICLE
Elizabeth Dong Nguyen, Vahid Nikoonejad Fard, Bernard Y Kim, Sarah Collins, Miranda Galey, Branden R Nelson, Paul Wakenight, Simone M Gable, Aaron McKenna, Theo K Bammler, Jim MacDonald, Daryl M Okamura, Jay Shendure, David R Beier, Jan Marino Ramirez, Mark W Majesky, Kathleen J Millen, Marc Tollis, Danny E Miller
There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from four different tissues...
August 8, 2023: G3: Genes—Genomes—Genetics
#40
JOURNAL ARTICLE
Rory Durcan, Gemma Roberts, Calum A Hamilton, Paul C Donaghy, Kim Howe, Sean J Colloby, Louise M Allan, Michael Firbank, Sarah Lawley, George S Petrides, Jim J Lloyd, John-Paul Taylor, John T O'Brien, Alan J Thomas
BACKGROUND AND OBJECTIVES: Progressive nigrostriatal pathway degeneration occurs in individuals with dementia with Lewy bodies (LB). Our objective was to investigate whether repeat 123[I]-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) single photon emission computed tomography (SPECT) can identify progressive dopaminergic loss in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB). METHODS: Individuals with MCI-LB and MCI due to Alzheimer disease (MCI-AD) underwent comprehensive clinical assessment, 123[I]-FP-CIT SPECT at baseline and annual reviews, and baseline cardiac 123 iodine metaiodobenzylguanidine (I-MIBG)...
September 19, 2023: Neurology
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