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https://www.readbyqxmd.com/read/29546524/prediction-of-chemotherapy-induced-nausea-and-vomiting-from-patient-reported-and-genetic-risk-factors
#1
Sonam Puri, Kelly A Hyland, Kristine Crowe Weiss, Gillian C Bell, Jhanelle E Gray, Richard Kim, Hui-Yi Lin, Aasha I Hoogland, Brian D Gonzalez, Ashley M Nelson, Anita Y Kinney, Stacy M Fischer, Daneng Li, Paul B Jacobsen, Howard L McLeod, Heather S L Jim
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. METHODS: Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score...
March 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29531875/the-british-columbia-emergency-medicine-network-a-paradigm-shift-in-a-provincial-system-of-emergency-care
#2
Riyad B Abu-Laban, Sharla Drebit, Ronald R Lindstrom, Chantel Archibald, Kim Eggers, Kendall Ho, Afshin Khazei, Adam Lund, Carolyn MacKinnon, Ray Markham, Julian Marsden, Ed Martin, Jim Christenson
As generalists, emergency practitioners face challenges in providing state-of-the-art care owing to the broad spectrum of practice and the rapid rate of new knowledge generation. Networks have become increasingly prevalent in health care, and it was in this backdrop, and the resulting opportunity to advance evidence-informed emergency care in the Canadian province of British Columbia (BC), that a new "Emergency Medicine Network" (EM Network) was launched in 2017. The EM Network consists of four programs, each led by a physician with expertise and a track record in the domain: (1) Clinical Resources; (2) Innovation; (3) Continuing Professional Development; and (4) Real-time Support...
January 4, 2018: Curēus
https://www.readbyqxmd.com/read/29512234/seroresponses-and-safety-of-13-valent-pneumococcal-conjugate-vaccination-in-kidney-transplant-recipients
#3
Claire Dendle, Rhonda L Stuart, Kevan R Polkinghorne, Anne Balloch, John Kanellis, Johnathan Ling, Megan Kummrow, Chelsea Moore, Karin Thursky, Jim Buttery, Kim Mulholland, Poh-Yi Gan, Stephen Holdsworth, William R Mulley
BACKGROUND: Conjugated pneumococcal vaccine is recommended for kidney transplant recipients however their immunogenicity and potential to trigger allograft rejection though generation of de-novo anti-human leucocyte antigen antibodies has not been well studied. METHODS: Clinically stable kidney transplant recipients participated in a prospective cohort study and received a single dose of 13-valent conjugate pneumococcal vaccine. Anti-pneumococcal IgG was measured for the 13 vaccine serotypes pre and post vaccination and functional anti-pneumococcal IgG for 4 serotypes post-vaccination...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29390880/magnetic-targeting-of-stem-cell-derivatives-enhances-hepatic-engraftment-into-structurally-normal-liver
#4
W Samuel Fagg, Naiyou Liu, Ming-Jim Yang, Ke Cheng, Eric Chung, Jae-Sung Kim, Gordon Wu, Jeffrey Fair
Attaining consistent robust engraftment in the structurally normal liver is an obstacle for cellular transplantation. Most experimental approaches to increase transplanted cells' engraftment involve recipient-centered deleterious methods such as partial hepatectomy or irradiation which may be unsuitable in the clinic. Here, we present a cell-based strategy that increases engraftment into the structurally normal liver using a combination of magnetic targeting and proliferative endoderm progenitor (EPs) cells...
December 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29344748/lead-sorption-characteristics-of-various-chicken-bone-part-derived-chars
#5
Jong-Hwan Park, Jim J Wang, Seong-Heon Kim, Se-Won Kang, Ju-Sik Cho, Ronald D Delaune, Yong Sik Ok, Dong-Cheol Seo
Recycling food waste for beneficial use is becoming increasingly important in resource-limited economy. In this study, waste chicken bones of different parts from restaurant industry were pyrolyzed at 600 °C and evaluated for char physicochemical properties and Pb sorption characteristics. Lead adsorption isotherms by different chicken bone chars were carried out with initial Pb concentration range of 1-1000 mg L-1 at pH 5. The Pb adsorption data were better described by the Langmuir model (R2 = 0.9289-0...
January 18, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29242294/-in-vivo-il-12-il-23p40-neutralization-blocks-th1-th17-response-after-allogeneic-hematopoietic-cell-transplantation
#6
Joseph Pidala, Francisca Beato, Jongphil Kim, Brian Betts, Heather Jim, Elizabeth Sagatys, John E Levine, James L M Ferrara, Umut Ozbek, Ernesto Ayala, Marco Davila, Hugo F Fernandez, Teresa Field, Mohamed A Kharfan-Dabaja, Divis Khaira, Farhad Khimani, Frederick L Locke, Asmita Mishra, Michael Nieder, Taiga Nishihori, Lia Perez, Marcie Riches, Claudio Anasetti
T-helper 1 and T-helper 17 lymphocytes mediate acute graft- versus -host disease (GvHD). Interleukin 12 is critical for T-helper 1 differentiation and interleukin 23 for T-helper 17 maintenance. Interleukin 12 and 23 are heterodimeric cytokines that share the p40 subunit (IL-12/IL-23p40). In a randomized, blinded, placebo-controlled trial, we examined the biological impact and clinical outcomes following IL-12/IL-23p40 neutralization using ustekinumab. Thirty patients received peripheral blood mobilized hematopoietic cell transplantation (HCT) from HLA-matched sibling or unrelated donors, received sirolimus plus tacrolimus as GvHD prophylaxis, and were randomized to ustekinumab versus placebo with 1:1 allocation after stratification by donor type...
March 2018: Haematologica
https://www.readbyqxmd.com/read/29112072/an-advanced-blt-humanized-mouse-model-for-extended-hiv-1-cure-studies
#7
Kerry J Lavender, Craig Pace, Kathrin Sutter, Ronald J Messer, Dakota L Pouncey, Nathan W Cummins, Sekar Natesampillai, Jim Zheng, Joshua Goldsmith, Marek Widera, Erik S Van Dis, Katie Phillips, Brent Race, Ulf Dittmer, George Kukolj, Kim J Hasenkrug
OBJECTIVE: Although bone marrow, liver, thymus (BLT)-humanized mice provide a robust model for HIV-1 infection and enable evaluation of cure strategies dependent on endogenous immune responses, most mice develop graft versus host disease (GVHD), limiting their utility for extended HIV cure studies. This study aimed to: evaluate the GVHD-resistant C57 black 6 (C57BL/6) recombination activating gene 2 (Rag2)γcCD47 triple knockout (TKO)-BLT mouse as a model to establish HIV-1 latency. Determine whether TKO-BLT mice could be maintained on antiretroviral therapy (ART) for extended periods of time...
January 2, 2018: AIDS
https://www.readbyqxmd.com/read/29047434/offline-jim-kim-finds-his-voice
#8
Richard Horton
No abstract text is available yet for this article.
October 14, 2017: Lancet
https://www.readbyqxmd.com/read/29028672/birth-cohort-consortium-of-asia-current-and-future-perspectives
#9
Reiko Kishi, Jun Jim Zhang, Eun-Hee Ha, Pau-Chung Chen, Ying Tian, Yankai Xia, Kenji J Tsuchiya, Kunihiko Nakai, Sungkyoon Kim, Soo-Jong Hong, Yun-Chul Hong, Jeong-Rim Lee, Hamid Jan B Jan Mohamed, Rajendra Prasad Parajuli, Linda S Adair, Yap Seng Chong, Yue Leon Guo, Shu-Li Wang, Muneko Nishijo, Teruhiko Kido, Pham The Tai, Sumal Nandasena
BACKGROUND: The environmental health of children is one of the great global health concerns. Exposures in utero and throughout development can have major consequences on later health. However, environmental risks or disease burdens vary from region to region. Birth cohort studies are ideal for investigating different environmental risks. METHODS: The principal investigators of three birth cohorts in Asia including the Taiwan Birth Panel Study (TBPS), the Mothers and Children's Environmental Health Study (MOCEH), and the Hokkaido Study on Environment and Children' Health (Hokkaido Study) coestablished the Birth Cohort Consortium of Asia (BiCCA) in 2011...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/28985577/characteristics-of-clinical-measurements-between-biomechanical-responders-and-non-responders-to-a-shoe-designed-for-knee-osteoarthritis
#10
Yongwook Kim, Jim Richards, Roy H Lidtke, Renato Trede
PURPOSE: The purpose of this study was to investigate the characteristics of biomechanical and clinical measurements in relation to the knee adduction moment when wearing a standard shoe and a shoe design for individuals with knee osteoarthritis (Flex-OA). METHODS: Kinematic and kinetic data were collected from thirty-two healthy individuals (64 knees) using a ten camera motion analysis system and four force plates. Subjects performed 5 walking trials under the two conditions and the magnitude of individuals' biomechanical responses where explored in relation to the clinical assessment of the Foot Posture Index, hip rotation range, strength of hip rotators, and active ankle-foot motion, all of which have been described as possible compensation mechanisms in knee osteoarthritis...
September 29, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28982333/cerebral-artery-vasoconstriction-is-endothelin-1-dependent-requiring-neurogenic-and-adrenergic-crosstalk
#11
Roel H L Haeren, Sieuwke A Hartmans, Jo De Mey, Govert Hoogland, Jim Dings, Olaf E M G Schijns, Sander M J van Kuijk, Kim Rijkers, Paul Schiffers, Koo J van Overbeeke
BACKGROUND: The regulation of cerebral arterial vasomotor tone involves several mechanisms. The role of sympathetic nerves and the adrenergic neurotransmitter, noradrenaline (NA), has been subject of debate for decades. Moreover, the specific role of endothelin-1 (ET-1) in cerebral arterial vasoconstriction has not been elucidated to date. In this study, we evaluated the contribution of NA and ET-1 to cerebral artery vasoconstriction. METHODS: Arterial responses of rat middle cerebral arteries, and human pial cerebral arteries to cumulative concentrations of NA and ET-1, and to electrical field stimulation (EFS), were evaluated...
October 5, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28959632/diacetyl-and-2-3-pentanedione-in-breathing-zone-and-area-air-during-large-scale-commercial-coffee-roasting-blending-and-grinding-processes
#12
Michael J McCoy, Kimberly A Hoppe Parr, Kim E Anderson, Jim Cornish, Matti Haapala, John Greivell
Recently described scientific literature has identified the airborne presence of 2,3-butanedione (diacetyl) and 2,3-pentanedione at concentrations approaching or potentially exceeding the current American Conference of Industrial Hygienists' (ACGIH) Threshold Limit Values (TLVs) at commercial coffee roasting and production facilities. Newly established National Institutes of Occupational Safety and Health (NIOSH) Recommended Exposure Limits for diacetyl and 2,3-pentanedione are even more conservative. Chronic exposure to these alpha-diketones at elevated airborne concentrations has been associated with lung damage, specifically bronchiolitis obliterans, most notably in industrial food processing facilities...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28921709/kidney-allograft-failure-in-the-steroid-free-immunosuppression-era-a-matched-case-control-study
#13
Mohamad M Alkadi, Jim Kim, Meredith J Aull, Joseph E Schwartz, John R Lee, Anthony Watkins, Jun B Lee, Darshana M Dadhania, Surya V Seshan, David Serur, Sandip Kapur, Manikkam Suthanthiran, Choli Hartono, Thangamani Muthukumar
We studied the causes and predictors of death-censored kidney allograft failure among 1670 kidney recipients transplanted at our center in the corticosteroid-free maintenance immunosuppression era. As of January 1, 2012, we identified 137 recipients with allograft failure; 130 of them (cases) were matched 1-1 for recipient age, calendar year of transplant, and donor type with 130 recipients with functioning grafts (controls). Median time to allograft failure was 29 months (interquartile range: 18-51). Physician-validated and biopsy-confirmed categories of allograft failure were as follows: acute rejection (21%), glomerular disease (19%), transplant glomerulopathy (13%), interstitial fibrosis tubular atrophy (10%), and polyomavirus-associated nephropathy (7%)...
November 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28917564/impact-of-institutional-procedural-volume-on-inhospital-outcomes-after-cardiac-resynchronization-therapy-device-implantation-us-national-database-2003-2011
#14
Ilhwan Yeo, Luke K Kim, Bruce B Lerman, Jim W Cheung
BACKGROUND: The relationship between hospital volume and outcomes for cardiac resynchronization therapy (CRT) implantations has not been well established. OBJECTIVE: The purpose of this study was to examine outcomes after CRT device implantation stratified by hospital volume using a large national inpatient database. METHODS: Using the National Inpatient Sample database, we identified all patients undergoing de novo CRT implants between 2003 and 2011...
December 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28838896/priorities-for-research-in-miscarriage-a-priority-setting-partnership-between-people-affected-by-miscarriage-and-professionals-following-the-james-lind-alliance-methodology
#15
Matthew Prior, Carmel Bagness, Jane Brewin, Arri Coomarasamy, Lucy Easthope, Barbara Hepworth-Jones, Kim Hinshaw, Emily O'Toole, Julie Orford, Lesley Regan, Nick Raine-Fenning, Judy Shakespeare, Rachel Small, Jim Thornton, Leanne Metcalf
OBJECTIVES: To identify and prioritise important research questions for miscarriage. DESIGN: A priority setting partnership using prospective surveys and consensus meetings following methods advocated by the James Lind Alliance. SETTING: UK. PARTICIPANTS: Women and those affected by miscarriage working alongside healthcare professionals. RESULTS: In the initial survey, 1093 participants (932 women who have experienced miscarriage, 8 partners, 17 family members, friends or colleagues, 104 healthcare professionals and eight charitable organisations) submitted 3279 questions...
August 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28683901/in-hospital-cardiovascular-complications-after-pancreas-transplantation-in-the-united-states-from-2003-to-2012
#16
MULTICENTER STUDY
Jim Kim, Joshua Schulman-Marcus, Anthony C Watkins, Dmitriy N Feldman, Rajesh Swaminathan, Jun B Lee, Thangamani Muthukumar, David Serur, Luke Kim, Choli Hartono
Large database studies detailing the risk of perioperative cardiovascular complications after pancreas transplant has been limited, perhaps because these outcomes are not captured by transplant registries. Greater data on the incidence and risks of such outcomes could provide additional insight for referring physicians and inform potential recipients of their risk. We performed a serial, cross-sectional analysis of the National Inpatient Sample, the largest publicly available inpatient database in the United States, to assess for the risk of cardiovascular complications after pancreas transplants in the United States from 2003 to 2012 (n = 13,399)...
August 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28652064/randomized-trial-on-the-effects-of-attentional-focus-on-motor-training-of-the-upper-extremity-using-robotics-with-individuals-after-chronic-stroke
#17
RANDOMIZED CONTROLLED TRIAL
Grace J Kim, Jim Hinojosa, Ashwini K Rao, Mitchell Batavia, Michael W O'Dell
OBJECTIVE: To compare the long-term effects of external focus (EF) and internal focus (IF) of attention after 4 weeks of arm training. DESIGN: Randomized, repeated-measures, mixed analysis of variance. SETTING: Outpatient clinic. PARTICIPANTS: Individuals with stroke and moderate-to-severe arm impairment living in the community (N=33; withdrawals: n=3). INTERVENTIONS: Four-week arm training protocol on a robotic device (12 sessions)...
October 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28549124/disclosure-and-donor-conceived-children
#18
Marilyn Crawshaw, Damian Adams, Sonia Allan, Eric Blyth, Kate Bourne, Claudia Brügge, Anne Chien, Antonia Clissa, Ken Daniels, Ellen Glazer, Jean Haase, Karin Hammarberg, Hans van Hooff, Jennie Hunt, Astrid Indekeu, Louise Johnson, Young Kim, Maggie Kirkman, Wendy Kramer, Ann Lalos, Charles Lister, Phyllis Lowinger, Erica Mindes, Jim Monach, Olivia Montuschi, Sheila Pike, Victoria Powell, Iolanda Rodino, Alice Ruby, Anne Margriet Schrijvers, Yukari Semba, Ruth Shidlo, Petra Thorn, Lois Tonkin, Marja Visser, Julia Woodward, Tewes Wischmann, Samantha Yee, Julianne E Zweifel
No abstract text is available yet for this article.
July 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28526881/biosorption-performance-of-encapsulated-candida-krusei-for-the-removal-of-copper-ii
#19
Chi Him Jim Luk, Joanne Yip, Chun Wah Marcus Yuen, Siu Kwong Pang, Kim Hung Lam, Chi Wai Kan
The use of microorganisms in biosorption is one of the most promising ways to remove trace amounts of heavy metal ions. Nevertheless, the enhancement of the successful removal of heavy metal ions by using different combinations of biosorbents is not generally guaranteed which leaves room to explore the application of the technique. In this study, the performance of free and immobilized forms of a yeast strain, Candida krusei (C. krusei), and calcium alginate (CaAlg) are evaluated for their ability to remove copper(II)...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419000/exercise-induced-autophagy-in-fatty-liver-disease
#20
Sung Kook Chun, Sooyeon Lee, Ming-Jim Yang, Christiaan Leeuwenburgh, Jae-Sung Kim
Hepatic steatosis prevails each year. Autophagy is integral in mitochondrial quality control and lipid homeostasis in the liver. No pharmacological strategies are currently available to reduce hepatic steatosis, but exercise has been known to improve clinical outcomes of chronic liver disease, particularly nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that exercise may improve NAFLD through enhancing autophagy.
July 2017: Exercise and Sport Sciences Reviews
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