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https://www.readbyqxmd.com/read/28300852/regression-analysis-of-local-skin-reactions-to-predict-clearance-of-actinic-keratosis-on-the-face-in-patients-treated-with-ingenol-mebutate-gel-experience-from-randomized-controlled-trials
#1
Shelbi Jim On, Kim Mark Knudsen, Torsten Skov, Mark Lebwohl
<p>Ingenol mebutate gel, a topical field treatment for actinic keratosis (AK), elicits inflammatory application-site reactions in most patients. This analysis explored the relationship between the intensity of local skin reactions (LSRs) and AK clearance, measured by the reduction in AK count from baseline in 218 patients who were treated for AK on the face in the pivotal Phase 3 studies. The analysis modeled the AK count at week 8, adjusted for baseline count, with the composite LSR score at 1 day after the last treatment application for each patient as a predictor to estimate the mean and 90% prediction interval for the percent reduction in AK count...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28289730/indirect-interspecies-regulation-transcriptional-and-physiological-responses-of-a-cyanobacterium-to-heterotrophic-partnership
#2
Hans C Bernstein, Ryan S McClure, Vera Thiel, Natalie C Sadler, Young-Mo Kim, William B Chrisler, Eric A Hill, Donald A Bryant, Margaret F Romine, Janet K Jansson, Jim K Fredrickson, Alexander S Beliaev
The mechanisms by which microbes interact in communities remain poorly understood. Here, we interrogated specific interactions between photoautotrophic and heterotrophic members of a model consortium to infer mechanisms that mediate metabolic coupling and acclimation to partnership. This binary consortium was composed of a cyanobacterium, Thermosynechococcus elongatus BP-1, which supported growth of an obligate aerobic heterotroph, Meiothermus ruber strain A, by providing organic carbon, O2, and reduced nitrogen...
March 2017: MSystems
https://www.readbyqxmd.com/read/28285698/impact-of-a-planned-dose-interruption-of-dacomitinib-in-the-treatment-of-advanced-non-small-cell-lung-cancer-archer-1042
#3
Dong-Wan Kim, Edward B Garon, Aminah Jatoi, Dorothy M Keefe, Mario E Lacouture, Stephen Sonis, Diana Gernhardt, Tao Wang, Nagdeep Giri, Jim P Doherty, Sashi Nadanaciva, Joseph O'Connell, Eric Sbar, Byoung Chul Cho
OBJECTIVES: Dacomitinib is a pan-HER inhibitor for advanced non-small-cell lung cancer (NSCLC). We explored the impact of a planned 4-day dacomitinib dose interruption on plasma exposure of dacomitinib and adverse events (AEs) of interest in Cohort III of the ARCHER 1042 study. MATERIALS AND METHODS: Patients, treatment-naïve for advanced NSCLC with EGFR activating mutations, received oral dacomitinib 45mg QD (once daily). A planned dose interruption occurred in Cycle 1 from Days 11 through 14...
April 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28259442/kawasaki-disease-and-immunisation-a-systematic-review
#4
Linny Kimly Phuong, Caterina Bonetto, Jim Buttery, Yolanda Brauchli Pernus, Rebecca Chandler, Patrizia Felicetti, Karen L Goldenthal, Merita Kucuku, Giuseppe Monaco, Barbara Pahud, Stanford T Shulman, Karina A Top, Francesco Trotta, Rolando Ulloa-Gutierrez, Frederick Varricchio, Sarah de Ferranti, Jane W Newburger, Nagib Dahdah, Surjit Singh, Jan Bonhoeffer, David Burgner
BACKGROUND: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation. METHODS: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. RESULTS: We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews...
March 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28214565/trends-and-outcomes-of-cardiac-resynchronization-therapy-upgrade-procedures-a-comparative-analysis-using-a-united-states-national-database-2003-2013
#5
Jim W Cheung, James E Ip, Steven M Markowitz, Christopher F Liu, George Thomas, Dmitriy N Feldman, Rajesh V Swaminathan, Bruce B Lerman, Luke K Kim
BACKGROUND: While outcomes after de novo CRT implantations have been reported, there are limited data on CRT upgrade procedures. OBJECTIVES: The purpose of this study to examine trends and in-hospital outcomes of patients undergoing upgrade to cardiac resynchronization therapy (CRT) procedures using a large, national inpatient database. METHODS: Using the National Inpatient Sample database, we identified all patients undergoing CRT upgrade and de novo CRT implants between 2003 and 2013...
February 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28196955/identification-of-human-junctional-adhesion-molecule-1-as-a-functional-receptor-for-the-hom-1-calicivirus-on-human-cells
#6
Stanislav V Sosnovtsev, Carlos Sandoval-Jaime, Gabriel I Parra, Christine M Tin, Ronald W Jones, Jo Soden, Donna Barnes, Jim Freeth, Alvin W Smith, Kim Y Green
The Hom-1 vesivirus was reported in 1998 following the inadvertent transmission of the animal calicivirus San Miguel sea lion virus to a human host in a laboratory. We characterized the Hom-1 strain and investigated the mechanism by which human cells could be infected. An expression library of 3,559 human plasma membrane proteins was screened for reactivity with Hom-1 virus-like particles, and a single interacting protein, human junctional adhesion molecule 1 (hJAM1), was identified. Transient expression of hJAM1 conferred susceptibility to Hom-1 infection on nonpermissive Chinese hamster ovary (CHO) cells...
February 14, 2017: MBio
https://www.readbyqxmd.com/read/28179509/iga-coated-e-coli-enriched-in-crohn-s-disease-spondyloarthritis-promote-th17-dependent-inflammation
#7
Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G Castellanos, Viola Woo, Fei Teng, Nhan L Tran, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E Diehl, Nadim J Ajami, Joseph F Petrosino, Xi K Zhou, Sergio Schwartzman, Lisa A Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J Scherl, Hsin-Jung Joyce Wu, Kenneth W Simpson, Randy S Longman
Peripheral spondyloarthritis (SpA) is a common extraintestinal manifestation in patients with active inflammatory bowel disease (IBD) characterized by inflammatory enthesitis, dactylitis, or synovitis of nonaxial joints. However, a mechanistic understanding of the link between intestinal inflammation and SpA has yet to emerge. We evaluated and functionally characterized the fecal microbiome of IBD patients with or without peripheral SpA. Coupling the sorting of immunoglobulin A (IgA)-coated microbiota with 16S ribosomal RNA-based analysis (IgA-seq) revealed a selective enrichment in IgA-coated Escherichia coli in patients with Crohn's disease-associated SpA (CD-SpA) compared to CD alone...
February 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28006952/comparison-of-antibody-responses-induced-by-rv144-vax003-and-vax004-vaccination-regimens
#8
Chitraporn Karnasuta, Siriwat Akapirat, Sirinan Madnote, Hathairat Savadsuk, Jiraporn Puangkaew, Surawach Rittiroongrad, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, James Tartaglia, Faruk Sinangil, Donald P Francis, Merlin L Robb, Mark S de Souza, Nelson L Michael, Jean-Louis Excler, Jerome H Kim, Robert J O'Connell, Nicos Karasavvas
The RV144 prime-boost regimen demonstrated efficacy against HIV acquisition while VAX003 and VAX004 did not. Although these trials differed by risk groups, immunization regimens, and immunogens, antibody responses may have contributed to the differences observed in vaccine efficacy. We assessed HIV-specific IgG, both total and subclass, and IgA binding to HIV envelope (Env): gp120 proteins and Cyclic V2 (CycV2) and CycV3 peptides and gp70 V1 V2 scaffolds in these 3 HIV vaccine trials. After two protein immunizations, IgG responses to 92TH023 gp120 (contained in ALVAC-HIV vaccine) were significantly higher in RV144 but responses to other Env were higher in the VAX trials lacking ALVAC-HIV...
January 30, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27979961/rt-qpcr-and-rt-digital-pcr-a-comparison-of-different-platforms-for-the-evaluation-of-residual-disease-in-chronic-myeloid-leukemia
#9
Mary Alikian, Alexandra S Whale, Susanna Akiki, Kim Piechocki, Celia Torrado, Thet Myint, Simon Cowen, Michael Griffiths, Alistair G Reid, Jane Apperley, Helen White, Jim F Huggett, Letizia Foroni
BACKGROUND: Tyrosine kinase inhibitors (TKIs) are the cornerstone of successful clinical management of patients with chronic myeloid leukemia (CML). Quantitative monitoring of the percentage of the BCR, RhoGEF, and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase fusion transcript BCR-ABL1(IS) (%BCR-ABL1(IS)) by reverse transcription-quantitative PCR (RT-qPCR) is the gold standard strategy for evaluating patient response to TKIs and classification into prognostic subgroups...
December 15, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27915135/primary-stability-and-viscoelastic-displacement-of-mini-implant-system-under-loading
#10
Jim Lee, Yong-Hoon Jeong, Joseph Pittman, Toru Deguchi, William M Johnston, Henry W Fields, Do-Gyoon Kim
BACKGROUND: The objectives of the current study were to examine the effects of mini-implant diameters on 1) primary stability before bone properties are changed by active peri-implant bone remodeling and 2) the time-dependent displacement of mini-implant systems in bone under a functional radial loading and their associations with bone mineral density. METHODS: Twenty one, 8mm length mini-implants (7 each for 1.4mm, 1.6mm, and 2mm diameters) were placed in mandibular sections of human cadavers (4 males and 3 females, average 69...
November 24, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27863715/kawasaki-disease-and-immunisation-standardised-case-definition-guidelines-for-data-collection-analysis
#11
Linny Kimly Phuong, Caterina Bonetto, Jim Buttery, Yolanda Brauchli Pernus, Rebecca Chandler, Karen L Goldenthal, Merita Kucuku, Giuseppe Monaco, Barbara Pahud, Stanford T Shulman, Karina A Top, Rolando Ulloa-Gutierrez, Frederick Varricchio, Sarah de Ferranti, Jane W Newburger, Nagib Dahdah, Surjit Singh, Jan Bonhoeffer, David Burgner
No abstract text is available yet for this article.
December 12, 2016: Vaccine
https://www.readbyqxmd.com/read/27711066/corrigendum-adjuvant-dependent-innate-and-adaptive-immune-signatures-of-risk-of-sivmac251-acquisition
#12
Monica Vaccari, Shari N Gordon, Slim Fourati, Luca Schifanella, Namal P M Liyanage, Mark Cameron, Brandon F Keele, Xiaoying Shen, Georgia D Tomaras, Erik Billings, Mangala Rao, Amy W Chung, Karen G Dowell, Chris Bailey-Kellogg, Eric P Brown, Margaret E Ackerman, Diego A Vargas-Inchaustegui, Stephen Whitney, Melvin N Doster, Nicolo Binello, Poonam Pegu, David C Montefiori, Kathryn Foulds, David S Quinn, Mitzi Donaldson, Frank Liang, Karin Loré, Mario Roederer, Richard A Koup, Adrian McDermott, Zhong-Min Ma, Christopher J Miller, Tran B Phan, Donald N Forthal, Matthew Blackburn, Francesca Caccuri, Massimiliano Bissa, Guido Ferrari, Vaniambadi Kalyanaraman, Maria G Ferrari, DeVon Thompson, Marjorie Robert-Guroff, Silvia Ratto-Kim, Jerome H Kim, Nelson L Michael, Sanjay Phogat, Susan W Barnett, Jim Tartaglia, David Venzon, Donald M Stablein, Galit Alter, Rafick-Pierre Sekaly, Genoveffa Franchini
No abstract text is available yet for this article.
October 6, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27695583/prospective-investigation-of-penile-length-with-newborn-male-circumcision-and-second-to-fourth-digit-ratio
#13
Jong Kwan Park, A Ram Doo, Joo Heung Kim, Hyung Sub Park, Jung Mo Do, Hwang Choi, Seung Chol Park, Myung Ki Kim, Young Beom Jeong, Hyung Jim Kim, Young Gon Kim, Yu Seob Shin
INTRODUCTION: We prospectively investigated the relationship between newborn male circumcision (NMC) and second to fourth digit ratio with penile length. METHODS: As participants for our study, we identified already circumcised young patients who visited our hospital for urological treatment. The age at which the circumcision had been done was assessed. The patients' height and weight were measured. Second to fourth digit ratio was calculated by measuring the second and fourth digit lengths...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27601928/relationship-between-severity-of-the-local-skin-reactions-and-the-rate-of-local-skin-reaction-resolution-in-patients-treated-with-ingenol-mebutate-gel
#14
Shelbi C Jim On, Kim Mark Knudsen, Torsten Skov, Mark Lebwohl
BACKGROUND: Ingenol mebutate gel is a topical field treatment for actinic keratosis (AK). The treatment elicits application-site reactions in most patients. This analysis evaluated the relationship between the severity of reactions and the speed of their resolution. METHODS: Patients in Phase III studies were treated for AKs on the face (n=218), scalp (n=56), and trunk and extremities (n=209). All of the patients were treated with either ingenol mebutate gel 0.015% once daily for three consecutive days (face/scalp) or ingenol mebutate gel 0...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27499452/osseous-injury-associated-with-ligamentous-tear-of-the-knee
#15
REVIEW
Chee Hwee Lee, Chih Feng Tan, Okwha Kim, Kyung Jin Suh, Min-Szu Yao, Wing P Chan, Jim S Wu
One of the most common knee injuries is ligament tear, which may initially manifest as an osseous injury in radiographs. Radiologists should therefore be able to recognize ligament tears of the knee as osseous abnormalities in images. This review focuses on the imaging features of knee ligament injuries and their related osseous injuries: anterior cruciate ligament (ACL) tear with Segond fracture; associated marrow contusion; ACL avulsion fracture; posterior cruciate ligament (PCL) tear with osseous avulsion of the ligament including arcuate sign; reverse Segond fracture; PCL avulsion fracture; medial collateral ligament tear with Pellegrini-Stieda disease; lateral collateral ligament tear with avulsion fracture of the fibular head; and patellar ligament injuries with Osgood-Schlatter and Sinding-Larsen-Johansson...
November 2016: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/27434225/national-sociodemographic-disparities-in-the-treatment-of-high-risk-prostate-cancer-do-academic-cancer-centers-perform-better-than-community-cancer-centers
#16
Brandon A Mahal, Yu-Wei Chen, Vinayak Muralidhar, Amandeep R Mahal, Toni K Choueiri, Karen E Hoffman, Jim C Hu, Christopher J Sweeney, James B Yu, Felix Y Feng, Simon P Kim, Clair J Beard, Neil E Martin, Quoc-Dien Trinh, Paul L Nguyen
BACKGROUND: Most major cancer organizations seek to reduce sociodemographic disparities in high-risk cancers partly by increasing access to theoretically high-quality, academic-oriented cancer care. The objective of this study was to determine whether academic centers have less sociodemographic treatment disparities than community centers using high-risk prostate cancer as a test case. METHODS: The National Cancer Data Base was used to identify 138,019 patients who were diagnosed with nonmetastatic, high-risk prostate cancer from 2004 to 2012...
July 19, 2016: Cancer
https://www.readbyqxmd.com/read/27321329/does-telemedicine-improve-treatment-outcomes-for-diabetes-a-meta-analysis-of-results-from-55-randomized-controlled-trials
#17
REVIEW
Dejun Su, Junmin Zhou, Megan S Kelley, Tzeyu L Michaud, Mohammad Siahpush, Jungyoon Kim, Fernando Wilson, Jim P Stimpson, José A Pagán
AIMS: To assess the overall effect of telemedicine on diabetes management and to identify features of telemedicine interventions that are associated with better diabetes management outcomes. METHODS: Hedges's g was estimated as the summary measure of mean difference in HbA1c between patients with diabetes who went through telemedicine care and those who went through conventional, non-telemedicine care using a random-effects model. Q statistics were calculated to assess if the effect of telemedicine on diabetes management differs by types of diabetes, age groups of patients, duration of intervention, and primary telemedicine approaches used...
June 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27308806/early-syphilis-among-men-who-have-sex-with-men-in-the-us-pacific-northwest-2008-2013-clinical-management-and-implications-for-prevention
#18
Emiko Petrosky, Robyn Neblett Fanfair, Kim Toevs, Malini DeSilva, Sean Schafer, Katrina Hedberg, Jim Braxton, Jaime Walters, Lauri Markowitz, Susan Hariri
Substantial increases in syphilis during 2008-2013 were reported in the US Pacific Northwest state of Oregon, especially among men who have sex with men (MSM). The authors aimed to characterize the ongoing epidemic and identify possible gaps in clinical management of early syphilis (primary, secondary, and latent syphilis ≤1 year) among MSM in Multnomah County, Oregon to inform public health efforts. Administrative databases were used to examine trends in case characteristics during 2008-2013. Medical records were abstracted for cases occurring in 2013 to assess diagnosis, treatment, and screening practices...
March 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27258546/correction-reproducibility-of-fluorescent-expression-from-engineered-biological-constructs-in-e-coli
#19
Jacob Beal, Traci Haddock-Angelli, Markus Gershater, Kim de Mora, Meagan Lizarazo, Jim Hollenhorst, Randy Rettberg
[This corrects the article DOI: 10.1371/journal.pone.0150182.].
2016: PloS One
https://www.readbyqxmd.com/read/27242221/selection-of-phage-displayed-human-antibody-fragments-specific-for-cd1b-presenting-the-mycobacterium-tuberculosis-glycolipid-ac2sgl
#20
Frank Camacho, María E Sarmiento, Fatima Reyes, Louise Kim, Jim Huggett, Marco Lepore, Oscar Otero, Martine Gilleron, Germain Puzo, Mohd Nor Norazmi, Graham Rook, Lucia Mori, Gennaro De Libero, Armando Acosta
OBJECTIVE/BACKGROUND: The development of new tools capable of targeting Mycobacterium tuberculosis (Mtb)-infected cells have potential applications in diagnosis, treatment, and prevention of tuberculosis. In Mtb-infected cells, CD1b molecules present Mtb lipids to the immune system (Mtb lipid-CD1b complexes). Because of the lack of CD1b polymorphism, specific Mtb lipid-CD1b complexes could be considered as universal Mtb infection markers. 2-Stearoyl-3-hydroxyphthioceranoyl-2'-sulfate-α-α'-d-trehalose (Ac2SGL) is specific for Mtb, and is not present in other mycobacterial species...
June 2016: International Journal of Mycobacteriology
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