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Jim kim

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https://www.readbyqxmd.com/read/29887426/atrial-fibrillation-and-heart-failure-with-preserved-ejection-fraction-insights-on-a-unique-clinical-phenotype-from-a-nationally-representative-united-states-cohort
#1
Parag Goyal, Zaid I Almarzooq, Jim Cheung, Hooman Kamel, Udhay Krishnan, Dmitriy N Feldman, Evelyn M Horn, Luke K Kim
BACKGROUND: Atrial fibrillation (AF) and heart failure often occur concomitantly, representing a clinical phenotype at high-risk for poor outcomes. Differences in the characteristics, management, and in-hospital outcomes of AF among those with heart failure with preserved ejection fraction (HFpEF) and those with heart failure with reduced ejection fraction (HFrEF) are not well characterized. METHODS AND RESULTS: Using the National Inpatient Sample, we identified hospitalizations in 2008-2012 for HFpEF and for HFrEF, with and without AF based on ICD-9-CM codes...
September 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29882688/policy-and-practice-relevant-youth-physical-activity-research-center-agenda
#2
Nisha Botchwey, Myron F Floyd, Keshia Pollack Porter, Carmen L Cutter, Chad Spoon, Tom L Schmid, Terry L Conway, J Aaron Hipp, Anna J Kim, M Renee Umstattd Meyer, Amanda L Walker, Tina J Kauh, Jim F Sallis
BACKGROUND: The Physical Activity Research Center developed a research agenda that addresses youth physical activity (PA) and healthy weight, and aligns with the Robert Wood Johnson Foundation's Culture of Health. This paper summarizes prioritized research studies with a focus on youth at higher risk for inactive lifestyles and childhood obesity in urban and rural communities. METHODS: Systematic literature reviews, a survey, and discussions with practitioners and researchers provided guidance on research questions to build evidence and inform effective strategies to promote healthy weight and PA in youth across race, cultural, and economic groups...
June 8, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29844398/single-shot-3d-coherent-diffractive-imaging-of-core-shell-nanoparticles-with-elemental-specificity
#3
Alan Pryor, Arjun Rana, Rui Xu, Jose A Rodriguez, Yongsoo Yang, Marcus Gallagher-Jones, Huaidong Jiang, Krishan Kanhaiya, Michael Nathanson, Jaehyun Park, Sunam Kim, Sangsoo Kim, Daewoong Nam, Yu Yue, Jiadong Fan, Zhibin Sun, Bosheng Zhang, Dennis F Gardner, Carlos Sato Baraldi Dias, Yasumasa Joti, Takaki Hatsui, Takashi Kameshima, Yuichi Inubushi, Kensuke Tono, Jim Yang Lee, Makina Yabashi, Changyong Song, Tetsuya Ishikawa, Henry C Kapteyn, Margaret M Murnane, Hendrik Heinz, Jianwei Miao
We report 3D coherent diffractive imaging (CDI) of Au/Pd core-shell nanoparticles with 6.1 nm spatial resolution with elemental specificity. We measured single-shot diffraction patterns of the nanoparticles using intense x-ray free electron laser pulses. By exploiting the curvature of the Ewald sphere and the symmetry of the nanoparticle, we reconstructed the 3D electron density of 34 core-shell structures from these diffraction patterns. To extract 3D structural information beyond the diffraction signal, we implemented a super-resolution technique by taking advantage of CDI's quantitative reconstruction capabilities...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29806054/complications-in-patients-with-intramedullary-nails-a-case-series-from-a-single-cambodian-surgical-clinic
#4
Erik Woelber, Audrey Martin, Douglas Van Citters, Craig Luplow, Michael Githens, Charlotte Kohn, Yong Jun Kim, Heang Oy, Jim Gollogly
PURPOSE: Since its development in 1999, the SIGN nail has been used in over 190,000 surgeries spanning 55 countries. To date, however, evaluation of SIGN nail outcomes has been limited to small prospective studies or large retrospective studies using SIGN's online database. This study uses the experience of a single, independent Cambodian surgical clinic to characterize common complications, provide commentary on ways to reduce the risk of those complications, and determine whether several observed nail fractures were due to metallurgic defects...
May 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29774638/loss-of-sirtuin-1-and-mitofusin-2-contributes-to-enhanced-ischemia-reperfusion-injury-in-aged-livers
#5
Sung Kook Chun, Sooyeon Lee, Joseph Flores-Toro, Rebecca Y U, Ming-Jim Yang, Kristina L Go, Thomas G Biel, Catherine E Miney, Schiley Pierre Louis, Brian K Law, Mary E Law, Elizabeth M Thomas, Kevin E Behrns, Christiaan Leeuwenburgh, Jae-Sung Kim
Ischemia/reperfusion (I/R) injury is a causative factor contributing to morbidity and mortality during liver resection and transplantation. Livers from elderly patients have a poorer recovery from these surgeries, indicating reduced reparative capacity with aging. Mechanisms underlying this age-mediated hypersensitivity to I/R injury remain poorly understood. Here, we investigated how sirtuin 1 (SIRT1) and mitofusin 2 (MFN2) are affected by I/R in aged livers. Young (3 months) and old (23-26 months) male C57/BL6 mice were subjected to hepatic I/R in vivo...
May 17, 2018: Aging Cell
https://www.readbyqxmd.com/read/29743361/a-novel-strategy-to-adapt-shiv-e1-carrying-env-from-an-rv144-volunteer-to-rhesus-macaques-coreceptor-switch-and-final-recovery-of-a-pathogenic-virus-with-exclusive-r5-tropism
#6
Hanna B Scinto, Sandeep Gupta, Swati Thorat, Muhammad M Mukhtar, Anthony Griffiths, Jennifer Delgado, Elizabeth Plake, Hemant K Vyas, Amanda Strickland, Siddappa N Byrareddy, David C Montefiori, Celia LaBranche, Ranajit Pal, Jim Treece, Sharon Orndorff, Maria Grazia Ferrari, Deborah Weiss, Agnes-Laurence Chenine, Robert McLinden, Nelson Michael, Jerome H Kim, Merlin Robb, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Ruth M Ruprecht
The Phase III RV144 HIV vaccine trial conducted in Thailand remains the only study to show efficacy in decreasing HIV acquisition risk. In Thailand, circulating recombinant forms of HIV clades A/E (CRF01_AE) predominate; in such viruses, env originates from clade E (HIV-E). We constructed a simian-human immunodeficiency virus (SHIV) chimera carrying env isolated from an RV144 placebo recipient in the SHIV-1157ipd3N4 backbone. The latter contains long terminal repeats (LTRs) with duplicated NF-κB sites, thus resembling HIV LTRs...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29719758/theoretical-study-of-strain-dependent-optical-absorption-in-a-doped-self-assembled-inas-ingaas-gaas-algaas-quantum-dot
#7
Tarek A Ameen, Hesameddin Ilatikhameneh, Archana Tankasala, Yuling Hsueh, James Charles, Jim Fonseca, Michael Povolotskyi, Jun Oh Kim, Sanjay Krishna, Monica S Allen, Jeffery W Allen, Rajib Rahman, Gerhard Klimeck
A detailed theoretical study of the optical absorption in doped self-assembled quantum dots is presented. A rigorous atomistic strain model as well as a sophisticated 20-band tight-binding model are used to ensure accurate prediction of the single particle states in these devices. We also show that for doped quantum dots, many-particle configuration interaction is also critical to accurately capture the optical transitions of the system. The sophisticated models presented in this work reproduce the experimental results for both undoped and doped quantum dot systems...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29546524/prediction-of-chemotherapy-induced-nausea-and-vomiting-from-patient-reported-and-genetic-risk-factors
#8
Sonam Puri, Kelly A Hyland, Kristine Crowe Weiss, Gillian C Bell, Jhanelle E Gray, Richard Kim, Hui-Yi Lin, Aasha I Hoogland, Brian D Gonzalez, Ashley M Nelson, Anita Y Kinney, Stacy M Fischer, Daneng Li, Paul B Jacobsen, Howard L McLeod, Heather S L Jim
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) is common among cancer patients. Early identification of patients at risk for CINV may help to personalize anti-emetic therapies. To date, few studies have examined the combined contributions of patient-reported and genetic risk factors to CINV. The goal of this study was to evaluate these risk factors. METHODS: Prior to their first chemotherapy infusion, participants completed demographic and risk factor questionnaires and provided a blood sample to measure genetic variants in ABCB1 (rs1045642) and HTR3B (rs45460698) as well as CYP2D6 activity score...
March 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29531875/the-british-columbia-emergency-medicine-network-a-paradigm-shift-in-a-provincial-system-of-emergency-care
#9
Riyad B Abu-Laban, Sharla Drebit, Ronald R Lindstrom, Chantel Archibald, Kim Eggers, Kendall Ho, Afshin Khazei, Adam Lund, Carolyn MacKinnon, Ray Markham, Julian Marsden, Ed Martin, Jim Christenson
As generalists, emergency practitioners face challenges in providing state-of-the-art care owing to the broad spectrum of practice and the rapid rate of new knowledge generation. Networks have become increasingly prevalent in health care, and it was in this backdrop, and the resulting opportunity to advance evidence-informed emergency care in the Canadian province of British Columbia (BC), that a new "Emergency Medicine Network" (EM Network) was launched in 2017. The EM Network consists of four programs, each led by a physician with expertise and a track record in the domain: (1) Clinical Resources; (2) Innovation; (3) Continuing Professional Development; and (4) Real-time Support...
January 4, 2018: Curēus
https://www.readbyqxmd.com/read/29512234/seroresponses-and-safety-of-13-valent-pneumococcal-conjugate-vaccination-in-kidney-transplant-recipients
#10
Claire Dendle, Rhonda L Stuart, Kevan R Polkinghorne, Anne Balloch, John Kanellis, Johnathan Ling, Megan Kummrow, Chelsea Moore, Karin Thursky, Jim Buttery, Kim Mulholland, Poh-Yi Gan, Stephen Holdsworth, William R Mulley
BACKGROUND: Conjugated pneumococcal vaccine is recommended for kidney transplant recipients, however, their immunogenicity and potential to trigger allograft rejection though generation of de novo anti-human leukocyte antigen antibodies has not been well studied. METHODS: Clinically stable kidney transplant recipients participated in a prospective cohort study and received a single dose of 13-valent conjugate pneumococcal vaccine. Anti-pneumococcal IgG was measured for the 13 vaccine serotypes pre and post vaccination and functional anti-pneumococcal IgG for 4 serotypes post vaccination...
April 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29390880/magnetic-targeting-of-stem-cell-derivatives-enhances-hepatic-engraftment-into-structurally-normal-liver
#11
W Samuel Fagg, Naiyou Liu, Ming-Jim Yang, Ke Cheng, Eric Chung, Jae-Sung Kim, Gordon Wu, Jeffrey Fair
Attaining consistent robust engraftment in the structurally normal liver is an obstacle for cellular transplantation. Most experimental approaches to increase transplanted cells' engraftment involve recipient-centered deleterious methods such as partial hepatectomy or irradiation which may be unsuitable in the clinic. Here, we present a cell-based strategy that increases engraftment into the structurally normal liver using a combination of magnetic targeting and proliferative endoderm progenitor (EPs) cells...
December 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29344748/lead-sorption-characteristics-of-various-chicken-bone-part-derived-chars
#12
Jong-Hwan Park, Jim J Wang, Seong-Heon Kim, Se-Won Kang, Ju-Sik Cho, Ronald D Delaune, Yong Sik Ok, Dong-Cheol Seo
Recycling food waste for beneficial use is becoming increasingly important in resource-limited economy. In this study, waste chicken bones of different parts from restaurant industry were pyrolyzed at 600 °C and evaluated for char physicochemical properties and Pb sorption characteristics. Lead adsorption isotherms by different chicken bone chars were carried out with initial Pb concentration range of 1-1000 mg L-1 at pH 5. The Pb adsorption data were better described by the Langmuir model (R2 = 0.9289-0...
January 18, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29242294/-in-vivo-il-12-il-23p40-neutralization-blocks-th1-th17-response-after-allogeneic-hematopoietic-cell-transplantation
#13
Joseph Pidala, Francisca Beato, Jongphil Kim, Brian Betts, Heather Jim, Elizabeth Sagatys, John E Levine, James L M Ferrara, Umut Ozbek, Ernesto Ayala, Marco Davila, Hugo F Fernandez, Teresa Field, Mohamed A Kharfan-Dabaja, Divis Khaira, Farhad Khimani, Frederick L Locke, Asmita Mishra, Michael Nieder, Taiga Nishihori, Lia Perez, Marcie Riches, Claudio Anasetti
T-helper 1 and T-helper 17 lymphocytes mediate acute graft- versus -host disease (GvHD). Interleukin 12 is critical for T-helper 1 differentiation and interleukin 23 for T-helper 17 maintenance. Interleukin 12 and 23 are heterodimeric cytokines that share the p40 subunit (IL-12/IL-23p40). In a randomized, blinded, placebo-controlled trial, we examined the biological impact and clinical outcomes following IL-12/IL-23p40 neutralization using ustekinumab. Thirty patients received peripheral blood mobilized hematopoietic cell transplantation (HCT) from HLA-matched sibling or unrelated donors, received sirolimus plus tacrolimus as GvHD prophylaxis, and were randomized to ustekinumab versus placebo with 1:1 allocation after stratification by donor type...
March 2018: Haematologica
https://www.readbyqxmd.com/read/29112072/an-advanced-blt-humanized-mouse-model-for-extended-hiv-1-cure-studies
#14
Kerry J Lavender, Craig Pace, Kathrin Sutter, Ronald J Messer, Dakota L Pouncey, Nathan W Cummins, Sekar Natesampillai, Jim Zheng, Joshua Goldsmith, Marek Widera, Erik S Van Dis, Katie Phillips, Brent Race, Ulf Dittmer, George Kukolj, Kim J Hasenkrug
OBJECTIVE: Although bone marrow, liver, thymus (BLT)-humanized mice provide a robust model for HIV-1 infection and enable evaluation of cure strategies dependent on endogenous immune responses, most mice develop graft versus host disease (GVHD), limiting their utility for extended HIV cure studies. This study aimed to: evaluate the GVHD-resistant C57 black 6 (C57BL/6) recombination activating gene 2 (Rag2)γcCD47 triple knockout (TKO)-BLT mouse as a model to establish HIV-1 latency. Determine whether TKO-BLT mice could be maintained on antiretroviral therapy (ART) for extended periods of time...
January 2, 2018: AIDS
https://www.readbyqxmd.com/read/29047434/offline-jim-kim-finds-his-voice
#15
Richard Horton
No abstract text is available yet for this article.
October 14, 2017: Lancet
https://www.readbyqxmd.com/read/29028672/birth-cohort-consortium-of-asia-current-and-future-perspectives
#16
Reiko Kishi, Jun Jim Zhang, Eun-Hee Ha, Pau-Chung Chen, Ying Tian, Yankai Xia, Kenji J Tsuchiya, Kunihiko Nakai, Sungkyoon Kim, Soo-Jong Hong, Yun-Chul Hong, Jeong-Rim Lee, Hamid Jan B Jan Mohamed, Rajendra Prasad Parajuli, Linda S Adair, Yap Seng Chong, Yue Leon Guo, Shu-Li Wang, Muneko Nishijo, Teruhiko Kido, Pham The Tai, Sumal Nandasena
BACKGROUND: The environmental health of children is one of the great global health concerns. Exposures in utero and throughout development can have major consequences on later health. However, environmental risks or disease burdens vary from region to region. Birth cohort studies are ideal for investigating different environmental risks. METHODS: The principal investigators of three birth cohorts in Asia including the Taiwan Birth Panel Study (TBPS), the Mothers and Children's Environmental Health Study (MOCEH), and the Hokkaido Study on Environment and Children' Health (Hokkaido Study) coestablished the Birth Cohort Consortium of Asia (BiCCA) in 2011...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/28985577/characteristics-of-clinical-measurements-between-biomechanical-responders-and-non-responders-to-a-shoe-designed-for-knee-osteoarthritis
#17
Yongwook Kim, Jim Richards, Roy H Lidtke, Renato Trede
PURPOSE: The purpose of this study was to investigate the characteristics of biomechanical and clinical measurements in relation to the knee adduction moment when wearing a standard shoe and a shoe design for individuals with knee osteoarthritis (Flex-OA). METHODS: Kinematic and kinetic data were collected from thirty-two healthy individuals (64 knees) using a ten camera motion analysis system and four force plates. Subjects performed 5 walking trials under the two conditions and the magnitude of individuals' biomechanical responses where explored in relation to the clinical assessment of the Foot Posture Index, hip rotation range, strength of hip rotators, and active ankle-foot motion, all of which have been described as possible compensation mechanisms in knee osteoarthritis...
September 29, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28982333/cerebral-artery-vasoconstriction-is-endothelin-1-dependent-requiring-neurogenic-and-adrenergic-crosstalk
#18
Roel H L Haeren, Sieuwke A Hartmans, Jo De Mey, Govert Hoogland, Jim Dings, Olaf E M G Schijns, Sander M J van Kuijk, Kim Rijkers, Paul Schiffers, Koo J van Overbeeke
BACKGROUND: The regulation of cerebral arterial vasomotor tone involves several mechanisms. The role of sympathetic nerves and the adrenergic neurotransmitter, noradrenaline (NA), has been the subject of debate for decades. Moreover, the specific role of endothelin-1 (ET-1) in cerebral arterial vasoconstriction has not been elucidated to date. In this study, we evaluated the contribution of NA and ET-1 to cerebral artery vasoconstriction. METHODS: Arterial responses of rat middle cerebral arteries, and human pial cerebral arteries to cumulative concentrations of NA and ET-1, and to Electrical Field Stimulation (EFS), were evaluated...
2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28959632/diacetyl-and-2-3-pentanedione-in-breathing-zone-and-area-air-during-large-scale-commercial-coffee-roasting-blending-and-grinding-processes
#19
Michael J McCoy, Kimberly A Hoppe Parr, Kim E Anderson, Jim Cornish, Matti Haapala, John Greivell
Recently described scientific literature has identified the airborne presence of 2,3-butanedione (diacetyl) and 2,3-pentanedione at concentrations approaching or potentially exceeding the current American Conference of Industrial Hygienists' (ACGIH) Threshold Limit Values (TLVs) at commercial coffee roasting and production facilities. Newly established National Institutes of Occupational Safety and Health (NIOSH) Recommended Exposure Limits for diacetyl and 2,3-pentanedione are even more conservative. Chronic exposure to these alpha-diketones at elevated airborne concentrations has been associated with lung damage, specifically bronchiolitis obliterans, most notably in industrial food processing facilities...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28921709/kidney-allograft-failure-in-the-steroid-free-immunosuppression-era-a-matched-case-control-study
#20
Mohamad M Alkadi, Jim Kim, Meredith J Aull, Joseph E Schwartz, John R Lee, Anthony Watkins, Jun B Lee, Darshana M Dadhania, Surya V Seshan, David Serur, Sandip Kapur, Manikkam Suthanthiran, Choli Hartono, Thangamani Muthukumar
We studied the causes and predictors of death-censored kidney allograft failure among 1670 kidney recipients transplanted at our center in the corticosteroid-free maintenance immunosuppression era. As of January 1, 2012, we identified 137 recipients with allograft failure; 130 of them (cases) were matched 1-1 for recipient age, calendar year of transplant, and donor type with 130 recipients with functioning grafts (controls). Median time to allograft failure was 29 months (interquartile range: 18-51). Physician-validated and biopsy-confirmed categories of allograft failure were as follows: acute rejection (21%), glomerular disease (19%), transplant glomerulopathy (13%), interstitial fibrosis tubular atrophy (10%), and polyomavirus-associated nephropathy (7%)...
November 2017: Clinical Transplantation
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