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Neurophatic pain

Torsten Gordh, Anne-Li Lind, Constantin Bodolea, Ellen Hewitt, Anders Larsson
Aims Cathepsin S has been reported to be a biomarker of spinal microglial activation, a process suggested to be involved in the pathophysiology of chronic neuropathic pain. So far this has been shown only in animal experiments. The aim of this study was to investigate the concentrations of cathepsin S in human cerebrospinal fluid (CSF) samples from a well-defined patient cohort suffering from neuropathic pain as compared to controls. Methods CSF samples from patients suffering from chronic neuropathic pain (n = 14) were analyzed for cathepsin S levels using commercial sandwich ELISAs (DY1183, R&D Systems, Minneapolis, MN, USA)...
December 29, 2017: Scandinavian Journal of Pain
Elke Mayumi Furuya-da-Cunha, Rimenez Rodrigues de Souza, Azair Canto-de-Souza
Previous studies have demonstrated that serotonin 5-HT2C receptors in the dorsal periaqueductal gray (dPAG) mediate both anxiety and antinociception in mice submitted to the elevated plus maze. The present study examined the effects of intra-dPAG infusion of the serotonin 5-HT2C receptor agonist (MK-212) in the defensive reactions and antinociception in mice with neurophatic pain confronted by a predator. Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve, and predator confrontation was performed using the rat exposure test (RET)...
July 1, 2016: Behavioural Brain Research
Dídac Sotorra-Figuerola, Alba Sánchez-Torres, Eduard Valmaseda-Castellón, Cosme Gay-Escoda
BACKGROUND: To determine the clinical characteristics of Continuous Neuropathic Orofacial Pain in patients that suffer Persistent Idiopathic Facial Pain (PIFP), Painful Post-Traumatic Trigeminal Neuropathy (PPTTN) or Burning Mouth Syndrome (BMS) and to describe their treatment. MATERIAL AND METHODS: A retrospective observational study was made, reviewing the clinical history of the patients diagnosed with Continuous Neuropathic Orofacial Pain between 2004 and 2011 at the Orofacial Pain Unit of the Master of Oral Surgery and Implantology of the University of Barcelona and at the Orofacial Pain Unit of the Teknon Medical Center of Barcelona...
April 2016: Journal of Clinical and Experimental Dentistry
Malek Zarei, Masoumeh Sabetkasaei, Taraneh Moini Zanjani
BACKGROUND: P2X4 receptor (P2X4R), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. Spinal nerve injury induces up-regulation of P2X4R on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. The present study was undertaken to determine whether paroxetine, an inhibitor of P2X4R, could attenuate allodynia and hyperalgesia in chronic constriction injury (CCI) model of neuropathic pain when used preemptively or after the sciatic nerve injury...
2014: Iranian Biomedical Journal
Ana Teresa Gaspar, Filipe Antunes
Type I complex regional pain syndrome is a neurophatic pain syndrome whose physiopathology is not yet fully understood. It mainly affects limb extremities and often occurs after local trauma. There is no consensus on the treatment, but early intervention seems important, particularly in the context of Physical Medicine and Rehabilitation. The authors review physiopathologic mechanisms and point to importance of an early diagnosis, since failure to recognize this clinical picture and the consequent delay in treatment may cause serious functional impairments...
November 2011: Acta Médica Portuguesa
Elenora Distrutti
Physiopathological mechanisms and treatment of pain remain a significant challenge. In the last decade, the gasotransmitter hydrogen sulphide (H(2)S) has received wide attention for its ability to act as a multilevel regulatory molecule in a variety of biologic functions in mammals including modulation of pain processing. Results from preclinical models of pain, including experimentally-induced somatic, neurophatic and visceral pain have provided non univocal finding and, depending on the model, H(2)S has been reported to exert either pronociceptive and antinociceptive effects...
April 2011: Inflammation & Allergy Drug Targets
Abby L Parrill, Daniel L Baker
The lysophospholipase D enzyme, autotaxin (ATX), has been linked to numerous human diseases including cancer, neurophatic pain, obesity and Alzheimer's disease. Although the ATX protein was initially purified and characterized in 1992, a link to bioactive lipid metabolism was not made until 2002. In the past decade, metal chelators, lysophospholipid product analogs, and more recently, small non-lipid inhibitors of the enzyme were successfully identified. The majority of these inhibitors have been characterized using recombinant purified ATX in vitro, with very few examples studied in more complex systems...
December 2010: Expert Opinion on Therapeutic Patents
Alexandru D P Papoiu, Gil Yosipovitch
IMPORTANCE OF THE FIELD: Capsaicin and its receptor, TRPV1, occupy a central place in current neurophysiological studies regarding pain transmission and have opened new avenues for understanding the role of transient receptor potential (TRP) receptors in itch processing. Substantial efforts in drug discovery are at present directed at vanilloid receptors for finding new remedies for pain and itch. AREAS COVERED IN THIS REVIEW: We provide an overview of the major clinical indications of capsaicin, primarily targeting pain and itch of various origins, with an emphasis on the usefulness of capsaicin in treating pruritus and dermatological conditions...
June 2010: Expert Opinion on Pharmacotherapy
Daniel Zurowski, Łukasz Nowak, Katarzyna Ciesielczyk, Anna Machowska, Piotr J Thor
Melatonin (MT) plays an important role in the regulation of physiological and neuroendocrine functions, such as control of circadian rhythms and synchronization of seasonal reproductive rhythms in mammals. Melatonin shows its antinocieeptive effects in a dose - dependent manner. Melatonin is influencing the mechanical allodynia but not thermal hyperalogia. Antinociceptive effects of melatonin are having the significant connection with the MT2 receptor stimulation and activation of the opioid system.
2008: Folia Medica Cracoviensia
Mürüvet Dayioğlu, Sema Tuncer, Ruhiye Reisli
Gabapentin is used as an analgesic in neuropathic pain. In this report a children with nerophatic pain because of mercury poising was followed-up for pain and side effects with the use of gabapentin. Pain reduction was good throughout the patient treatment. Severe side effects did not occur. Gabapentin was effective and well tolerated in the treatment of neuropathic pain in children.
April 2008: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
Emilio M Capmourteres, Diana Finkel
Conventionally, analgesic treatment is accomplished by three principal drug groups, like nonsteroidal anti-inflammatory drugs, opioids, and local anesthetics, through different administration routes and modalities. Currently, those analgesics are complemented with coadjuvant and coanalgesic drugs, particularly the psychotropic drugs, specially in somatic or visceral pain, inflammatory, neurophatic or oncologic types. Recently, best understanding of pathophysiological scopes relatives to inflammatory processes and neural damage in pain, makes possible an optimum and rational employment of those drugs...
June 2002: Vertex: Revista Argentina de Psiquiatriá
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