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Juvenile diabetes

Ann Haerskjold, Marie Linder, Lonny Henriksen, Simon Francis Thomsen, Helle Kieler, Henrik Ravn, Lone Graff Stensballe
BACKGROUND: Treatment with biologic pharmaceuticals may be associated with an increased risk of immune-mediated disease. Palivizumab is a humanized monoclonal antibody designed to provide passive immunity against respiratory syncytial virus infection. Palivizumab is primarily used in preterm children known to be immunologically immature. The long-term effect of palivizumab in terms of autoimmune diseases has not yet been investigated. AIM: Our objective was to investigate whether exposure to palivizumab was associated with the development of autoimmune diseases in children...
September 24, 2016: Paediatric Drugs
Anouk Verwoerd, Nienke M Ter Haar, Sytze de Roock, Sebastiaan J Vastert, Debby Bogaert
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The pathogenesis of JIA is thought to be the result of a combination of host genetic and environmental triggers. However, the precise factors that determine one's susceptibility to JIA remain to be unravelled. The microbiome has received increasing attention as a potential contributing factor to the development of a wide array of immune-mediated diseases, including inflammatory bowel disease, type 1 diabetes and rheumatoid arthritis...
September 20, 2016: Pediatric Rheumatology Online Journal
Afzal Ahmad, Benedicta D'Souza, Charu Yadav, Ashish Agarwal, Anand Kumar, M Nandini, Vivian D'Souza, A M Poornima, Nutan Kamath
Alstrom's syndrome (AS) is a rare autosomal recessive ciliopathic condition affecting 1:10,00,000 children. It's a single gene disorder of ALMS1 on chromosome 2 with multisystem involvement with cone-rod retinal dystrophy causing juvenile blindness, obesity, insulin resistance, type 2 Diabetes mellitus, hypogonadism and sensorineural hearing loss. Till now only 800 patients with this disorder has been identified so far. In this report, we describe the case of a 9-year old male boy from south India. He had been initially referred for polyphagia, polyuria, polydipsia, generalized weakness from 1 weeks...
October 2016: Indian Journal of Clinical Biochemistry: IJCB
Michael C Kwa, Kaveh Ardalan, Anne E Laumann, Beatrice Nardone, Dennis P West, Jonathan I Silverberg
OBJECTIVE: To assess the validity of using ICD-9-CM code 710.3 to identify adult patients with dermatomyositis in outpatient and inpatient settings. METHODS: Electronic medical records were examined for adult patients with ICD-9 code 710.3 between January 2001 and November 2014 (n=511). Physician diagnosis, clinical findings and diagnostic testing results were recorded. A dermatomyositis rating scale was assigned based on classic cutaneous findings and at least 2 additional clinical and diagnostic findings from the Bohan criteria...
August 26, 2016: Arthritis Care & Research
Katharina Paulmichl, Mensud Hatunic, Kurt Højlund, Aleksandra Jotic, Michael Krebs, Asimina Mitrakou, Francesca Porcellati, Andrea Tura, Peter Bergsten, Anders Forslund, Hannes Manell, Kurt Widhalm, Daniel Weghuber, Christian-Heinz Anderwald
BACKGROUND: The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids are components of other insulin-sensitivity indices but their measurement is expensive. Easier and more affordable tools are of interest for both pediatric and adult patients. METHODS: Study participants from the Relationship Between Insulin Sensitivity and Cardiovascular Disease [43...
September 2016: Clinical Chemistry
Angeles Vinuesa, Carlos Pomilio, Martin Menafra, Maria Marta Bonaventura, Laura Garay, María Florencia Mercogliano, Roxana Schillaci, Victoria Lux Lantos, Fernando Brites, Juan Beauquis, Flavia Saravia
The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies - constitute major risk factors for neurodegenerative disorders such as Alzheimer's disease (AD), sharing insulin resistance, inflammation and associated cognitive impairment. However, cerebral cellular and molecular pathways involved are not yet clearly understood. Thus, our aim was to study the impact of a non-severe high fat diet (HFD) that resembles western-like alimentary habits, particularly involving juvenile stages where the brain physiology and connectivity are in plain maturation...
October 2016: Psychoneuroendocrinology
S Cotard, A Nouni, V Jaquinandi, G Gladu, A Kaladji, G Mahé
Peripheral arterial disease (PAD) encompasses disease of all arteries of the body except the coronary arteries. The main etiology whatever the patient's age is atherosclerosis. Different etiologies can induce PAD especially when patients are younger than 50 years old and have no cardiovascular risk factors (smoking, hypertension, diabetes…). PAD that appears before 50 years old can be named juvenile PAD (JPAD) although there is no consensus about the definition. The aim of this work is to present the different etiologies of JPAD according to their hereditary, acquired or mixed origins...
September 2016: Annales de Cardiologie et D'angéiologie
V Dvorakova, H Kolarova, M Magner, M Tesarova, H Hansikova, J Zeman, T Honzik
BACKGROUND: Mitochondrial myopathy, Encephalopathy, Lactic Acidosis and Stroke-like episodes syndrome (MELAS) is a common mitochondrial disorder with varying multisystemic clinical manifestation. We present a comprehensive clinical picture of 50 Czech m.3243A>G carriers with emphasis on the sequence of symptoms in symptomatic patients. RESULTS: Symptoms developed in 33 patients (66%) and 17 carriers remained unaffected (34%). The age of onset varied from 1month to 47years of age, with juvenile presentation occurring in 53% of patients...
August 2016: Molecular Genetics and Metabolism
Helen Clapin, Helen Phelan, Loren Bruns, Richard Sinnott, Peter Colman, Maria Craig, Timothy Jones
Australasia is a region with a high incidence of type 1 diabetes (T1D). There are approximately 140 000 individuals with T1D, and of these 10 000 are children. Although the region covers a huge geographical area, most children with T1D are managed by tertiary academic centers in the major capital cities. Local longitudinal data collection has been in place for several decades in most of these centers, however ongoing national data collection had not been attempted. In 2012, with funding from the Juvenile Diabetes Research Foundation (JDRF) Australian Type 1 Clinical Research Network, a national collaboration was formed to provide ongoing longitudinal collection of T1D patient characteristics and outcomes...
September 2016: Journal of Diabetes Science and Technology
Sharon Levy, Fatma Dedeoglu, Jonathan M Gaffin, Katharine C Garvey, Elizabeth Harstad, Andrew MacGinnitie, Paul A Rufo, Qian Huang, Rosemary E Ziemnik, Lauren E Wisk, Elissa R Weitzman
BACKGROUND: In an effort to reduce barriers to screening for alcohol use in pediatric primary care, the National Institute on Alcoholism and Alcohol Abuse (NIAAA) developed a two-question Youth Alcohol Screening Tool derived from population-based survey data. It is unknown whether this screening tool, designed for use with general populations, accurately identifies risk among youth with chronic medical conditions (YCMC). This growing population, which comprises nearly one in four youth in the US, faces a unique constellation of drinking-related risks...
2016: PloS One
Dagmar Prochazkova, Zuzana Hruba, Petra Konecna, Jarmila Skotakova, Lenka Fajkusova
BACKGROUND: The Wolfram-like syndrome-WFSL is a rare autosomal dominant disease characterised by the triad: congenital progressive hearing loss, diabetes mellitus and optic atrophy. CASE REPORT: The case of a boy with the juvenile form of diabetes mellitus, which clinically matched the symptoms of the Wolfram syndrome, was studied using molecular-genetic methods. At the age of 3¼ years diabetes mellitus was diagnosed in a boy with severe psychomotor retardation, failure to thrive, a dysmorphic face with Peters anomaly type III (i...
May 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
Simone Pisano, Gennaro Catone, Stefania Veltri, Valentina Lanzara, Marco Pozzi, Emilio Clementi, Raffaella Iuliano, Maria Pia Riccio, Sonia Radice, Massimo Molteni, Annalisa Capuano, Antonella Gritti, Giangennaro Coppola, Annarita Milone, Carmela Bravaccio, Gabriele Masi
During the past decade, a substantial increase in the use of second generation antipsychotics (SGAs) has occurred for a number of juvenile psychiatric disorders, often as off-label prescriptions. Although they were thought to be safer than older, first generation antipsychotics, mainly due to a lower risk of neurological adverse reactions, recent studies have raised significant concerns regarding their safety regarding metabolic, endocrinological and cardiovascular side effects. Aim of this paper is to update with a narrative review, the latest findings on safety of SGAs in youths...
2016: Italian Journal of Pediatrics
Nicole Glaser, Christopher Little, Weei Lo, Michael Cohen, Daniel Tancredi, Heike Wulff, Martha O'Donnell
BACKGROUND: Diabetic ketoacidosis (DKA) causes brain injuries in children ranging from subtle to life-threatening. Previous studies suggest that DKA-related brain injury may involve both stimulation of Na-K-Cl cotransport and microglial activation. Other studies implicate the Na-K-Cl cotransporter and the Ca-activated K channel KCa3.1 in activation of microglia and ischemia-induced brain edema. In this study, we determined whether inhibiting cerebral Na-K-Cl cotransport or KCa3.1 could reduce microglial activation and decrease DKA-related inflammatory changes in the brain...
May 13, 2016: Pediatric Diabetes
V Krishnan, J Thirunavukkarasu
INTRODUCTION: Self blood glucose monitoring is an important context of self care in the management of diabetes mellitus. All the guidelines must be followed while performing self blood glucose monitoring and tracking of values is essential to facilitate the physician while titrating the drugs and /or doses of anti diabetes medication. Self titration by patients following self monitoring must be discouraged. AIM: To assess the knowledge and practice of self blood glucose monitoring among diabetes patients and extent of self titration of anti diabetes medicines among diabetes patients based on self blood glucose monitoring...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Debbie E Feldman, Évelyne Vinet, Anick Bérard, Ciarán Duffy, Beth Hazel, Garbis Meshefedjian, Marie-Pierre Sylvestre, Sasha Bernatsky
OBJECTIVE: To determine whether women with a history of juvenile arthritis are at higher risk for heart disease and hypertension, and for developing adverse maternal outcomes: gestational diabetes, maternal hypertension and preeclampsia/eclampsia. METHODS: We designed a nested case-control study from a cohort of first-time mothers with prior physician billing codes suggesting juvenile arthritis, and a matched comparison group without juvenile arthritis. For the nested case control design, we selected 3 controls for each case for the outcomes of heart disease (n=403), pre-pregnancy hypertension (n=66), gestational diabetes (n=285), maternal hypertension (n=561) and pre-eclampsia/eclampsia (n=236)...
April 25, 2016: Arthritis Care & Research
Bradley P Weegman, Michael J Taylor, Simona C Baicu, Kate Mueller, Timothy D O'Brien, John Wilson, Klearchos K Papas
Diabetes is a major health problem worldwide and there is substantial interest in developing xenogeneic islet transplantation as a potential treatment. The potential to relieve the demand on an inadequate supply of human pancreata is dependent upon the efficiency of techniques for isolating and culturing islets from the source pancreata. Porcine islets are favored for xenotransplantation, but mature pigs (>2 years) present logistic and economic challenges and young pigs (3-6 months) have not yet proven to be an adequate source...
April 22, 2016: Cell Transplantation
P Komminoth
Polyglandular autoimmune syndromes (PGAS), also known as autoimmune polyendocrinopathy syndromes (APS), are a heterogeneous group of rare, genetically caused diseases of the immune system which lead to inflammatory damage of various endocrine glands resulting in malfunctions. In addition, autoimmune diseases of non-endocrine organs may also be found. Early diagnosis of PGAS is often overlooked because of heterogeneous symptoms and the progressive occurrence of the individual diseases. The two most important forms of PGAS are the juvenile and adult types...
May 2016: Der Pathologe
Sabbir Khan, Gopabandhu Jena
Recent evidence highlighted that there is a link between type-1 diabetes mellitus and histone deacetylases (HDACs) due to their involvement in beta-cell differentiation, proliferation, and function. The present study aimed to investigate the protective role of valproic acid (VPA) on beta-cell proliferation, function, and apoptosis in juvenile diabetic rat. Diabetes was induced in juvenile Sprague-Dawley rats by streptozotocin (75 mg/kg, i.p.) and VPA was administered at the doses of 150 and 300 mg/kg/day for 3 weeks by oral route...
September 2016: Journal of Biochemical and Molecular Toxicology
Betul Sozeri, Basak Yildiz Atikan, Kadriye Ozdemir, Sevgi Mir
An increased incidence of cardiovascular disease has been found in rheumatic disorders. Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children. Prolonged immunological inflammatory process leads these patients to an early onset of atherosclerosis. We aimed to assess the presence of early vascular dysfunction in patients with systemic onset juvenile idiopathic arthritis (sJIA) and investigate the role of therapy sJIA in vascular health. Thirty-three patients (22 males, 11 females) diagnosed with sJIA according to the International League of Associations for Rheumatology criteria were compared to 72 age- and sex-matched controls...
July 2016: Clinical Rheumatology
Eva Lévy, Marie-Claude Stolzenberg, Julie Bruneau, Sylvain Breton, Bénédicte Neven, Sylvie Sauvion, Mohammed Zarhrate, Patrick Nitschké, Alain Fischer, Aude Magérus-Chatinet, Pierre Quartier, Frédéric Rieux-Laucat
LRBA (lipopolysaccharide-responsive and beige-like anchor protein) deficiency associates immune deficiency, lymphoproliferation, and various organ-specific autoimmunity. To date, prevalent symptoms are autoimmune cytopenias and enteropathy, and lymphocytic interstitial lung disease. In 2 siblings from a consanguineous family presenting with early onset polyautoimmunity, we presumed autosomal recessive inheritance and performed whole exome sequencing. We herein report the first case of early-onset, severe, chronic polyarthritis associated with LRBA deficiency...
July 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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