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https://www.readbyqxmd.com/read/28094969/investigating-biogenetic-hypotheses-of-the-securinega-alkaloids-enantioselective-total-syntheses-of-secu-amamine-e-ent-virosine-a-and-bubbialine
#1
Robin Wehlauch, Simone M Grendelmeier, Hideki Miyatake-Ondozabal, Alexander H Sandtorv, Manuel Scherer, Karl Gademann
The synthesis of the Securinega alkaloid secu'amamine E (ent-virosine A) has been accomplished for the first time in 12 steps and 8.5% overall yield. In addition, bubbialine has been prepared and characterized. These two alkaloids and bubbialidine, all featuring an azabicyclo[2.2.2]octane core, were rearranged to their azabicyclo[3.2.1]octane congeners, a framework found in many Securinega alkaloids. These experiments suggest that azabicyclo[2.2.2]octane derivatives could serve as intermediates in the biosynthesis of the rearranged azabicyclo[3...
January 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/28088743/socioeconomic-differences-in-adolescent-substance-abuse-treatment-participation-and-long-term-outcomes
#2
Camillia K Lui, Stacy A Sterling, Felicia W Chi, Yun Lu, Cynthia I Campbell
Socioeconomic status (SES) has been consistently linked to poorer access, utilization and outcomes of health care services, but this relationship has been understudied in adolescent substance abuse treatment research. This study examined SES differences in adolescent's treatment participation and long-term outcomes of abstinence and 12-step attendance over five years after treatment. Data are from 358 adolescents (ages 13-18) who were recruited at intake to substance abuse treatment between 2000 and 2002 at four Kaiser Permanente Northern California outpatient treatment programs...
January 6, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28050185/comparing-acceptance-and-commitment-group-therapy-and-12-steps-narcotics-anonymous-in-addict-s-rehabilitation-process-a-randomized-controlled-trial
#3
Manoochehr Azkhosh, Ali Farhoudianm, Hemn Saadati, Fateme Shoaee, Leila Lashani
Objective: Substance abuse is a socio-psychological disorder. The aim of this study was to compare the effectiveness of acceptance and commitment therapy with 12-steps Narcotics Anonymous on psychological well-being of opiate dependent individuals in addiction treatment centers in Shiraz, Iran. Method: This was a randomized controlled trial. Data were collected at entry into the study and at post-test and follow-up visits. The participants were selected from opiate addicted individuals who referred to addiction treatment centers in Shiraz...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28049204/rapid-drug-desensitization-with-biologics-a-single-center-experience-with-four-biologics
#4
Sevim Bavbek, Reşat Kendirlinan, Pamir Çerçi, Seda Altıner, Şadan Soyyiğit, Zeynep Çelebi Sözener, Ömür Aydın, Reyhan Gümüşburun
BACKGROUND: Rapid drug desensitization (RDD) induces a temporary tolerance to biologics which induce hypersensitivity reactions (HSRs). Data are limited regarding the use of RDD outside the USA. Our purpose was to report our data on RDD to rituximab, infliximab, cetuximab, and trastuzumab. METHODS: The study was conducted as a retrospective chart review of patients with symptoms of HSRs to biologics. HSRs were classified as grades I, II, and III, based on their severity...
January 4, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28017180/comparison-of-12-step-groups-to-mutual-help-alternatives-for-aud-in-a-large-national-study-differences-in-membership-characteristics-and-group-participation-cohesion-and-satisfaction
#5
Sarah E Zemore, Lee Ann Kaskutas, Amy Mericle, Jordana Hemberg
BACKGROUND: Many studies suggest that participation in 12-step groups contributes to better recovery outcomes, but people often object to such groups and most do not sustain regular involvement. Yet, research on alternatives to 12-step groups is very sparse. The present study aimed to extend the knowledge base on mutual help group alternatives for those with an alcohol use disorder (AUD), sampling from large, active, abstinence-focused groups including Women for Sobriety (WFS), LifeRing, and SMART Recovery (SMART)...
February 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28001380/assembly-of-the-limonoid-architecture-by-a-divergent-approach-total-synthesis-of-%C3%A2-andirolide-n-via-%C3%A2-8%C3%AE-hydroxycarapin
#6
Alexander W Schuppe, Timothy R Newhouse
We report the first total synthesis of the limonoid andirolide N using a 12-step sequence from commercially available materials. The final step of this route demonstrates the chemical feasibility of our biosynthetic proposal that andirolide N arises from 8α-hydroxycarapin. The strategic use of a degraded limonoid as a platform for the synthesis of more structurally complex congeners may be a general approach to obtain limonoids with diverse functional properties.
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27984008/treatment-of-alcohol-use-disorder-in-patients-with-alcoholic-liver-disease
#7
REVIEW
Lorenzo Leggio, Mary R Lee
Alcohol is a leading cause of liver disease worldwide. Although alcohol abstinence is the crucial therapeutic goal for patients with alcoholic liver disease, these patients have less access to psychosocial, behavioral and/or pharmacological treatments for alcohol use disorder. Psychosocial and behavioral therapies include 12-step facilitation, brief interventions, cognitive behavioral therapy, and motivational enhancement therapy. In addition to medications approved by the Food and Drug Administration (FDA) for alcohol use disorder (disulfiram, naltrexone and acamprosate), recent efforts to identify potential new treatments have yielded promising candidate pharmacotherapies...
October 28, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27981724/why-the-mechanisms-of-12-step-behaviour-change-should-matter-to-clinicians
#8
David Best
No abstract text is available yet for this article.
December 15, 2016: Addiction
https://www.readbyqxmd.com/read/27966918/oxidative-entry-into-the-illicium-sesquiterpenes-enantiospecific-synthesis-of-pseudoanisatin
#9
Kevin Hung, Matthew L Condakes, Takahiro Morikawa, Thomas J Maimone
Illicium sesquiterpenes have been the subject of numerous synthetic efforts due to their ornate and highly oxidized structures as well as significant biological activities. Herein we report the first chemical synthesis of (+)-pseudoanisatin from the abundant feedstock chemical cedrol (∼$50 USD/kg) in 12 steps using extensive site-selective C(sp(3))-H bond functionalization. Significantly, this work represents a novel oxidative strategic template for future approaches to these natural products and their analogs...
December 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27936374/testing-a-matching-hypothesis-for-emerging-adults-in-project-match-during-treatment-and-one-year-outcomes
#10
Jordan P Davis, Brandon G Bergman, Douglas C Smith, John F Kelly
OBJECTIVE: Compared with older adults, emerging adults (18-29 years old) entering treatment typically have less severe alcohol use consequences. Also, their unique clinical presentations (e.g., modest initial abstinence motivation) and developmental contexts (e.g., drinking-rich social networks) may make a straightforward implementation of treatments developed for adults less effective. Yet, this has seldom been examined empirically. This study was a secondary analysis of Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity) data examining (a) overall differences between emerging adults and older adults (≥30 years old) on outcomes during treatment and at 1-year follow-up, and (b) whether emerging adults had poorer outcomes on any of the three Project MATCH treatments in particular...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27919387/impacts-of-structuring-the-electronic-health-record-results-of-a-systematic-literature-review-from-the-perspective-of-secondary-use-of-patient-data
#11
REVIEW
Riikka Vuokko, Päivi Mäkelä-Bengs, Hannele Hyppönen, Minna Lindqvist, Persephone Doupi
PURPOSE: To explore the impacts that structuring of electronic health records (EHRs) has had from the perspective of secondary use of patient data as reflected in currently published literature. This paper presents the results of a systematic literature review aimed at answering the following questions; (1) what are the common methods of structuring patient data to serve secondary use purposes; (2) what are the common methods of evaluating patient data structuring in the secondary use context, and (3) what impacts or outcomes of EHR structuring have been reported from the secondary use perspective...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27899120/violence-narratives-of-mexican-women-treated-in-mutual-aid-residential-centers-for-addiction-treatment
#12
Ignacio Lozano-Verduzco, Martha Romero-Mendoza, Rodrigo Marín-Navarrete
BACKGROUND: Violence against women is a social and public health issue in Mexico. The aim of this article is to explore violence among an understudied group of women, who attended Mutual-Aid Residential Centers for Addiction Treatment and experienced stigma both as women and addicts. These centers are particular kind of addiction treatment services that stem from 12-step philosophy, but that have been found to manipulate said philosophy and exercise extreme forms of psychological and physical violence...
November 30, 2016: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/27805281/moderate-to-vigorous-physical-activity-but-not-sedentary-time-is-associated-with-musculoskeletal-health-outcomes-in-a-cohort-of-australian-middle-aged-women
#13
Feitong Wu, Karen Wills, Laura L Laslett, Brian Oldenburg, Graeme Jones, Tania Winzenberg
Associations between physical activity and time spent sedentary and musculoskeletal outcomes remain unclear in middle-aged adults. This study aimed to describe associations between objectively-measured physical activity and sedentary time and musculoskeletal health outcomes in middle-aged women. This cross-sectional study from a population-based sample of 309 women (age 36 to 57 years) examined associations of total physical activity (accelerometer counts/min of wear time), and time spent sedentary, in light physical activities and moderate-to-vigorous physical activities (MVPA) (by Actigraph GT1M accelerometer) with lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD) (by dual-energy X-ray absorptiometry), lower limb muscle strength (LMS), and functional mobility and balance tests (timed up and go test [TUG], functional reach test [FRT], lateral reach test [LRT], and step test [ST]) using linear regression...
November 2, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27768308/synthesis-of-chamobtusin-a-from-dehydroabietylamine
#14
Naoki Mori, Kazuma Kuzuya, Hidenori Watanabe
Chamobtusin A, a unique diterpene alkaloid isolated from Chamaecyparis obtusa cv. tetragon, is considered to be biosynthesized from an abietane diterpenoid. On the basis of this biosynthetic hypothesis, ferruginol (15) was synthesized from (+)-dehydroabietylamine and then biomimetically transformed into (-)-chamobtusin A in 6 steps (12 steps from (+)-dehydroabietylamine).
December 2, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27687715/voxel-wise-grey-matter-asymmetry-analysis-in-left-and-right-handers
#15
Sebastian Ocklenburg, Patrick Friedrich, Onur Güntürkün, Erhan Genç
Handedness is thought to originate in the brain, but identifying its structural correlates in the cortex has yielded surprisingly incoherent results. One idea proclaimed by several authors is that structural grey matter asymmetries might underlie handedness. While some authors have found significant associations with handedness in different brain areas (e.g. in the central sulcus and precentral sulcus), others have failed to identify such associations. One method used by many researchers to determine structural grey matter asymmetries is voxel based morphometry (VBM)...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27684277/psychosocial-interventions-for-psychostimulant-misuse
#16
Silvia Minozzi, Rosella Saulle, Franco De Crescenzo, Laura Amato
BACKGROUND: Psychostimulant misuse is a continuously growing medical and social burden. There is no evidence proving the efficacy of pharmacotherapy. Psychosocial interventions could be a valid approach to help patients in reducing or ceasing drug consumption. OBJECTIVES: To assess the effects of psychosocial interventions for psychostimulant misuse in adults. SEARCH METHODS: We searched the Cochrane Drugs and Alcohol Group Specialised Register (via CRSLive); Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; CINAHL; Web of Science and PsycINFO, from inception to November 2015...
September 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27619953/catalytic-enantioselective-total-synthesis-of-hypocrolide-a
#17
Chuang Qiao, Wen Zhang, Jing-Chun Han, Chuang-Chuang Li
The first and catalytic enantioselective total synthesis of hypocrolide A (>99% ee) in 12 steps, as well as other botryanes, is described. The absolute configurations of these compounds have been unambiguously confirmed or reassigned accordingly. The key reactions in this study include an unusual rhodium-catalyzed intramolecular [4 + 2] cycloaddition and a biomimetic oxidative [3 + 2] cycloaddition based on our revised biogenetic pathway.
October 7, 2016: Organic Letters
https://www.readbyqxmd.com/read/27563698/sideways-walk-test-reliability-and-association-with-lower-limb-motor-function-after-stroke
#18
Shamay S M Ng, Bobby K C Lau, Gilbert T C Law, Choco W K Wom, Tai-Wa Liu, Eric W C Tam, Mimi M Y Tse, Shirley S M Fong
OBJECTIVES: To investigate (i) the intra-rater, inter-rater and test-retest reliability of sideways walk test times and counts in individuals with stroke; (ii) their correlations with stroke-specific measures of impairment; (iii) the cut-off sideways walk test times and counts between stroke survivors and healthy controls; and (iv) the minimum detectable changes in the sideways walk test times and counts. DESIGN: Cross-sectional study. SETTING: University-based rehabilitation centre...
October 5, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27529730/protecting-group-free-total-synthesis-of-lycopodine-via-phosphoric-acid-promoted-alkyne-aza-prins-cyclization
#19
Donghui Ma, Zhuliang Zhong, Zaimin Liu, Mingjie Zhang, Shiyan Xu, Dengyu Xu, Dengpeng Song, Xingang Xie, Xuegong She
A protecting-group-free route for the total synthesis of (-)-lycopodine was demonstrated in only 8 steps from Wade's fawcettimine enone (12 steps from commercial availiable (R)-(+)-pulegone). The key core of this alkaloid was constructed through a phosphoric acid promoted and highly stereocontrolled alkyne aza-Prins cyclization reaction, synchronously establishing the bridged B-ring and the C13 quaternary stereocenter. Importantly, the synthesis further features a new efficient approach for the preparation of other lycopodine-type alkaloids...
September 2, 2016: Organic Letters
https://www.readbyqxmd.com/read/27499276/strategies-for-derisking-translational-processes-for-biomedical-technologies
#20
Mohamed Abou-El-Enein, Georg N Duda, Elliott A Gruskin, David W Grainger
Inefficient translational processes for technology-oriented biomedical research have led to some prominent and frequent failures in the development of many leading drug candidates, several designated investigational drugs, and some medical devices, as well as documented patient harm and postmarket product withdrawals. Derisking this process, particularly in the early stages, should increase translational efficiency and streamline resource utilization, especially in an academic setting. In this opinion article, we identify a 12-step guideline for reducing risks typically associated with translating medical technologies as they move toward prototypes, preclinical proof of concept, and possible clinical testing...
August 4, 2016: Trends in Biotechnology
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