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https://www.readbyqxmd.com/read/28421637/a-new-approach-to-models-of-the-4-5-dihydroxycyclopentenone-core-of-the-kodaistatins-a-d-elucidation-of-the-diol-configuration-in-kodaistatin-a
#1
Reinhard Brückner, David Peter
The kodaistatins are natural products from Aspergillus terreus. Being strongly anti-diabetic they hold some promise of a novel diabetes cure. However, considerations of that kind face two drawbacks. (1) The kodaistatins contain a heavily substituted pulvinone/cyclopentenone combination. (2) The kodaistatins are 1,2-diols, whose 3D structure have not been assigned yet. However, we can exclude two of the four possible stereostructures. We conclude that kodaistatin A is a trans-, not a cis-diol, from NMR comparisons with a pair of cis,trans-isomeric kodaistatin models, which we synthesized in 11 and 12 steps, respectively...
April 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28414174/iterative-integration-of-multiple-copy-pathway-genes-in-yarrowia-lipolytica-for-heterologous-%C3%AE-carotene-production
#2
Shuliang Gao, Yangyang Tong, Li Zhu, Mei Ge, Yian Zhang, Daijie Chen, Yu Jiang, Sheng Yang
β-Carotene is a terpenoid molecule with high hydrophobicity that is often used as an additive in foods and feed. Previous work has demonstrated the heterologous biosynthesis of β-carotene from an intrinsic high flux of acetyl-CoA in 12 steps through 11 genes in Yarrowia lipolytica. Here, an efficient biosynthetic pathway capable of producing 100-fold more β-carotene than the baseline construct was generated using strong promoters and multiple gene copies for each of the 12 steps. Using fed-batch fermentation with an optimized medium, the engineered pathway could produce 4g/L β-carotene, which was stored in lipid droplets within engineered Y...
April 13, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28412463/frameworks-for-adaptation-of-health-guidelines-a-methodological-survey
#3
REVIEW
Andrea Darzi, Elias A Abou-Jaoude, Arnav Agarwal, Chantal Lakis, Wojtek Wiercioch, Nancy Santesso, Hneine Brax, Fadi El-Jardali, Holger J Schünemann, Elie A Akl
BACKGROUND: Our objective was to identify and describe published frameworks for adaptation of clinical, public health and health services guidelines. METHODS: We included reports describing methods of adaptation of guidelines in sufficient detail to allow its reproducibility. We searched Medline, and EMBASE databases. We also searched personal files, as well manuals and handbooks of organizations and professional societies that proposed methods of adaptation and adoption of guidelines...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28410131/substance-use-disorder-a-bio-directional-subset-of-reward-deficiency-syndrome
#4
Kenneth Blum, Mark Gold, Zsolt Demetrovics, Trevor Archer, Panayotis K Thanos, David Baron, Rajendra D Badgaiyan
This commentary is to inform clinicians challenged with an increase in people seeking treatment for Substance Use Disorder (SUD), that the ninety percent revolving door, is, in part, due to post-withdrawal, untreated neurotoxicity. This impairment attenuates neurotransmitter signaling and compromises resting state functional connectivity, leading to unwanted sequelae including depression, sleep disturbances, sensation seeking, lack of satisfaction and impulsivity. Neuroimaging studies indicate that neurobiological recovery can take years...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28406363/insurance-receipt-and-readiness-for-opportunities-under-the-affordable-care-act-a-national-survey-of-treatment-providers-for-substance-use-disorders
#5
Lydia Aletraris, Mary Bond Edmond, Paul M Roman
This study measures the readiness of substance use disorder (SUD) treatment to use opportunities under the Affordable Care Act by examining Medicaid and private insurance acceptance between 2011 and 2013, as well as center characteristics associated with acceptance. Data for this study were from a random sample of SUD treatment centers in the United States. Interviews were conducted on site and face to face, with administrative and clinical directors. We employed logistic regression analyses to examine Medicaid acceptance and private insurance acceptance...
April 13, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28357872/enantioselective-total-synthesis-of-lysergol-a-formal-anti-carbopalladation-heck-cascade-as-the-key-step
#6
Bastian Milde, Martin Pawliczek, Peter G Jones, Daniel B Werz
The enantioselective synthesis of (+)-lysergol was completed in 12 steps and an overall yield of 13% starting from a known literature precursor. The key step relies on a domino reaction containing a formal anti-carbopalladation, which is terminated by a β-silyl-directed Heck reaction. During this transformation, the two six-membered rings of the ergot scaffold are formed in a completely stereospecific manner.
April 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28357866/enantioselective-construction-of-the-abcde-pentacyclic-core-of-the-strychnos-alkaloids
#7
Adam D Gammack Yamagata, Darren J Dixon
An efficient enantioselective 12-step synthesis of the ABCDE pentacyclic core of the Strychnos alkaloids is described. A key feature of this approach is an organocatalyzed enantioselective desymmetrization to generate the morphan core in high ee and dr. After palladium-catalyzed installation of the indole moiety, a subsequent 5-exo-trig dearomatizing atom transfer radical cyclization was developed to construct the C-ring. Following a series of functional group interconversions, the pentacyclic amine core was obtained with all the relevant architecture including five stereocenters pertaining to the Strychnos alkaloids...
April 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28350226/integration-of-care-in-the-implementation-of-the-affordable-care-act-changes-in-treatment-services-in-a-national-sample-of-centers-treating-substance-use-disorders
#8
Lydia Aletraris, Paul M Roman, Jana Pruett
This study examined patterns of medicalization in substance use disorder (SUD) that are aligned with the goals of the Affordable Care Act (ACA). Using a nationally representative sample of SUD treatment programs, we examined changes in several treatment domains. While observed changes were modest, they were in directions that support the thrust of the ACA. Specifically, we found an increase in the percentage of treatment referrals from other health care providers. We found an increase in the number of physicians for programs that did have a physician on staff, and an increase in counselors certified in treating alcohol and drug addiction...
March 28, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28337338/synthesis-of-malhamensilipin-a-exploiting-iterative-epoxidation-chlorination-experimental-and-computational-analysis-of-epoxide-derived-chloronium-ions
#9
J Saska, W Lewis, R S Paton, R M Denton
We report a 12-step catalytic enantioselective formal synthesis of malhamensilipin A (3) and diastereoisomeric analogues from (E)-2-undecenal. The convergent synthesis relied upon iterative epoxidation and phosphorus(v)-mediated deoxydichlorination reactions as well a titanium-mediated epoxide-opening to construct the C11-C16 stereohexad. The latter transformation occurred with very high levels of stereoretention regardless of the C13 configuration of the parent epoxide, implicating anchimeric assistance of either the γ- or δ-chlorine atoms, and the formation of chloretanium or chlorolanium ions, respectively...
December 11, 2016: Chemical Science
https://www.readbyqxmd.com/read/28333533/a-randomized-clinical-trial-of-behavioral-couples-therapy-versus-individually-based-treatment-for-drug-abusing-women
#10
Timothy J O'Farrell, Jeremiah A Schumm, Marie M Murphy, Patrice M Muchowski
OBJECTIVE: Behavioral couples therapy (BCT) is more efficacious than individually-based therapy (IBT) for substance and relationship outcomes among substance use disorder patients. This study compared BCT with IBT for drug-abusing women. METHOD: Sixty-one women, mostly White, late 30s, with primary substance use disorder other than alcohol (74% opioid), and male partners were randomized to 26 sessions over 13 weeks of BCT plus 12-step-oriented IBT (i.e., BCT + IBT) or IBT...
April 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28332912/twelve-tips-for-the-production-of-digital-chalk-talk-videos
#11
Jasmine Rana, Henrike Besche, Barbara Cockrill
Increasingly over the past decade, faculty in medical and graduate schools have received requests from digital millennial learners for concise faculty-made educational videos. At our institution, over the past couple of years alone, several hundred educational videos have been created by faculty who teach in a flipped-classroom setting of the pre-clinical medical school curriculum. Despite the appeal and potential learning benefits of digital chalk-talk videos first popularized by Khan Academy, we have observed that the conceptual and technological barriers for creating chalk-talk videos can be high for faculty...
March 23, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28332749/bioinspired-asymmetric-synthesis-of-hispidanin%C3%A2-a
#12
Fuzhuo Li, Qian Tu, Sijia Chen, Lei Zhu, Yu Lan, Jianxian Gong, Zhen Yang
The first enantiospecific synthesis of hispidanin A (4), a dimeric diterpenoid from the rhizomes of Isodon hispida, was achieved with a longest linear sequence of 12 steps in 6.5 % overall yield. A key component is the use of the abundant and naturally occurring diterpenoids (+)-sclareolide and (+)-sclareol as starting materials, which enables the gram-scale preparation of the key intermediates totarane (1) and s-trans-12E,14-labdadien-20,8β-olide (2). Subsequently a thermal or an erbium-catalyzed intermolecular Diels-Alder reaction of totarane (1) with labdadienolide (2) provide convergent and rapid access to the natural product hispidanin A (4)...
March 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28328221/chemical-synthesis-of-biosurfactant-succinoyl-trehalose-lipids
#13
Santanu Jana, Sumana Mondal, Suvarn S Kulkarni
Herein, we report, for the first time, a strategy to differentiate O4/O4' positions of 1,1'-α,α-trehalose via regioselective protection or site-selective functionalization and its application in the first chemical synthesis of succinoyl trehalose lipids. The biosurfactant glycolipids were obtained in 11-12 steps starting from trehalose in time span of 8-10 days and 11-12% overall yields.
April 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28317510/predictors-and-outcomes-of-twelve-step-sponsorship-of-stimulant-users-secondary-analyses-of-a-multisite-randomized-clinical-trial
#14
Dennis C Wendt, Kevin A Hallgren, Dennis C Daley, Dennis M Donovan
OBJECTIVE: This secondary data analysis explored predictors and outcomes of having a 12-step sponsor among individuals receiving treatment for stimulant use disorders, inclusive of four types of 12-step groups (Narcotics Anonymous, Alcoholics Anonymous, Cocaine Anonymous, and Crystal Meth Anonymous). METHOD: For a multisite randomized clinical trial, participants (N = 471; 59% women) were recruited among adult patients in 10 U.S. community treatment programs. Participants were randomized into treatment as usual (TAU) or a 12-step facilitation (TSF) intervention: Stimulant Abuser Groups to Engage in 12-Step (STAGE-12)...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28258333/older-and-younger-african-americans-story-schemas-and-experiences-of-living-with-hiv-aids
#15
Andrea Nevedal, Stewart Neufeld, Mark Luborsky, Andrea Sankar
This paper reports findings from a study that compared older (n = 21, ≥ age 50) and younger (n = 96, ≤ age 49) African Americans' stories (N = 117) of living with HIV/AIDS to determine how they make sense of the experience. The purpose was to: (1) identify and describe the cultural models African Americans use to inform their stories of living with HIV/AIDS, and (2) to compare older and younger adults' HIV stories. To characterize the cultural models engaged in the telling of these HIV stories, we conducted schema analysis...
March 3, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/28252470/asymmetries-identified-in-sit-to-stand-task-explain-physical-function-after-hip-fracture
#16
Robert A Briggs, Jeff R Houck, Micah J Drummond, Julie M Fritz, Paul C LaStayo, Robin L Marcus
BACKGROUND: Several known demographic and functional characteristics combine to predict physical function after hip fracture. Long-term weight-bearing asymmetries, evident during functional movements after hip fracture, contribute to limited mobility and large asymmetries in muscle function are linked to a high rate of injurious falls. Although postfracture mobility is commonly measured as whole body movement, a force-plate imbedded chair can identify individual limb contributions to an important task like moving from a sitting to standing position...
March 1, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28238981/academic-community-partnership-for-medical-missions-lessons-learned-and-practical-guidance-for-global-health-service-learning-experiences
#17
Yen H Dang, Frank J Nice, Hoai-An Truong
To facilitate an academic-community partnership for sustainable medical mis-sions, a 12-step process was created for an interprofessional, global health educational, and service-learning experience for students and faculty in a school of pharmacy and health professions. Lessons learned and practical guidance are provided to implement similar global health opportunities.
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28194270/total-synthesis-of-a-key-series-of-vinblastines-modified-at-c4-that-define-the-importance-and-surprising-trends-in-activity
#18
Shouliang Yang, Kuppusamy Sankar, Colin K Skepper, Timothy J Barker, John C Lukesh, Daniel M Brody, Manuela M Brütsch, Dale L Boger
The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole [4 + 2]/[3 + 2] cycloaddition cascade in which electronically mismatched electron-deficient trisubstituted alkenes and unactivated trisubstituted alkenes were found to productively initiate the cycloaddition cascade with tethered electron-deficient 1,3,4-oxadiazoles...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28185995/study-protocol-community-links-to-establish-alcohol-recovery-clear-for-women-leaving-jail
#19
Jennifer E Johnson, Yael Chatav Schonbrun, Bradley Anderson, Megan Kurth, Christine Timko, Michael Stein
PURPOSE: This article describes the protocol for a randomized effectiveness trial of a method to link alcohol use disordered women who are in pretrial jail detention with post-release 12-step mutual help groups. BACKGROUND: Jails serve 15 times more people per year than do prisons and have very short stays, posing few opportunities for treatment or treatment planning. Alcohol use is associated with poor post-jail psychosocial and health outcomes including sexually transmitted diseases and HIV, especially for women...
April 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28169002/the-c8-side-chain-is-one-of-the-key-functional-group-of-garcinol-for-its-anti-cancer-effects
#20
Xin-Ying Zhou, Jing Cao, Chao-Ming Han, Shu-Wen Li, Chen Zhang, Yin-Duan Du, Qian-Qian Zhou, Xin-Yan Zhang, Xin Chen
Garcinol from the fruit rind of Garcinia indica shows anti-carcinogenic and anti-inflammatory properties, but its mechanism and key functional groups were still need to be identified. Our previous computer modeling suggested that the C8 side chain of Garcinol is so large that it may influence the bioactivity of the compound. 8-Me Garcinol, a derivative of Garcinol in which the bulky side chain at the C8 position of Garcinol is replaced with a much smaller methyl group, was synthesized through a 12-step procedure starting from 1,3-cyclohexanedione...
January 22, 2017: Bioorganic Chemistry
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