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https://www.readbyqxmd.com/read/28340143/protecting-pain-patients-the-evaluation-of-a-chronic-pain-educational-intervention
#1
Simon Holliday, Chris Hayes, Adrian Dunlop, Simon Morgan, Amanda Tapley, Kim Henderson, Briony Larance, Parker Magin
Introduction. : Advocacy and commercially funded education successfully reduced barriers to the provision of long-term opioid analgesia. The subsequent escalation of opioid prescribing for chronic noncancer pain has seen increasing harms without improved pain outcomes. Methods. : This was a one-group pretest-posttest design study. A multidisciplinary team developed a chronic pain educational package for general practitioner trainees emphasizing limitations, risk-mitigation, and deprescribing of opioids with transition to active self-care...
March 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339738/a-multi-biomarker-score-measuring-disease-activity-in-rheumatoid-arthritis-patients-tapering-adalimumab-or-etanercept-predictive-value-for-clinical-and-radiographic-outcomes
#2
Chantal A M Bouman, Aatke van der Maas, Noortje van Herwaarden, Eric H Sasso, Frank H J van den Hoogen, Alfons A den Broeder
Objective.: The aim was to evaluate the predictive value of the baseline multi-biomarker disease activity (MBDA) score in long-standing RA patients with low disease activity tapering TNF inhibitors (TNFi) for successful tapering or discontinuation, occurrence of flare and major flare, and radiographic progression. Methods.: Dose REduction Strategies of Subcutaneous TNF inhibitors (Dutch Trial Register, NTR 3216) is an 18-month non-inferiority randomized controlled trial comparing tapering of TNFi until discontinuation or flaring with usual care (UC) in long-standing RA patients with stable low disease activity...
February 22, 2017: Rheumatology
https://www.readbyqxmd.com/read/28333370/influence-of-nickel-titanium-rotary-systems-with-varying-tapers-on-the-biomechanical-behaviour-of-maxillary-first-premolars-under-occlusal-forces-a-finite-element-analysis-study
#3
S Askerbeyli Ors, A Serper
AIM: To evaluate the effect of three nickel-titanium (Ni-Ti) rotary systems with varying tapers on stress distribution and to analyse potential fracture patterns as well as the volume of fracture-susceptible regions in two-rooted maxillary premolars. METHODOLOGY: The root canals of three single-rooted premolars were prepared with either HeroShaper (Micro-Mega, Besançon, France) to (size 30, .04 taper), Revo-S (Micro-Mega) to AS30 (size 30, .06 taper) or ProTaper Universal (Dentsply Maillefer, Ballaigeus, Switzerland) to F3 (size 30, ...
March 23, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28331963/study-of-loma-acerinae-microsporidia-detected-from-three-ponto-caspian-gobies-gobiidae-in-ukraine
#4
Mykola Ovcharenko, Piotr Wróblewski, Yuriy Kvach, Oleksandra Drobiniak
A previously recognized Glugea-belonging Microsporidia (G. melanostomi, G. markievichi, G. naidenovi) were found in the intestinal mucosa of Neogobius melanostomus, N. fluviatilis, and Proterorhinchus semilunaris (Teleostei, Gobiidae) from lower Dnieper River and Black Sea coastal inlets, Ukraine. Light microscope observations demonstrated small spherical xenomes about 0.35 mm in diameter filled by developmental stages of parasites. Mature spores were ellipsoidal, slightly narrowed at anterior pole, sometimes ovoid or elongate in shape approximately 3...
March 23, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28331873/rapid-corneal-thinning-and-perforated-ulcerative-keratitis-in-a-patient-with-relapsing-polychondritis
#5
Tracy Hiu Ting Lai, Nikki Far, Alvin Lerrmann Young, Vishal Jhanji
BACKGROUND: To report rapid corneal thinning and perforation in a case with relapsing polychondritis. CASE PRESENTATION: A 43 year-old male diagnosed with relapsing polychondritis suffered from bilateral scleritis, bilateral swelling of pinna, saddle nose and tracheal stenosis. The patient presented with right eye pain and redness for one month. Slit lamp examination of the right eye showed 80% peripheral corneal thinning between 3 and 7 o'clock. The best-corrected visual acuity (BCVA) was 1...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28329512/propranolol-for-infantile-hemangiomas-in-developing-countries
#6
Josette McMichael, Leslie P Lawley
BACKGROUND: Propranolol is the treatment of choicefor complicated infantile hemangiomas (IH). However,in some locations, propranolol has not yet becomestandard of care. To our knowledge, until 2014,propranolol had not been used in Afghanistan totreat IH. OBJECTIVES: To raise further awareness thatpropranolol is the treatment of choice for complicatedIH, suggest a propranolol induction, maintenance,and taper protocol, show an example of therapeuticsuccess in a resource-limited country, and discusspotential challenges...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329438/influence-of-clinical-use-on-physical-structural-surface-properties-and-electrochemical-potential-of-niti-endodontic-instruments
#7
E S J Pereira, C C F Amaral, J A P Gomes, O A Peters, V T L Buono, M G A Bahia
AIM: To investigate the surface morphology and electrochemical potential of superelastic (SE), M-Wire (MW), and shape memory technology (SMT) NiTi instruments before and after single clinical use in vivo. METHODOLOGY: A total of 60 ProTaper Universal F2 (PTU - SE), ProTaper Next X2 (PTN - MW), Typhoon (TYP), Hyflex (HF) and Vortex Blue (VB), the last three SMT, and size 25, .06 taper (n = 6 of each type) files were examined. Scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS) and electrochemical potential analysis were employed before and after clinical use...
March 22, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28326723/-current-dental-implant-design-and-its-clinical-importance
#8
Lin Ye
The development of clinical implant dentistry was intensively affected by dental implant design improvement and innovation, which brought about new concept, even milestone-like changes of clinical protocol. The current improvements of dental implant design and their clinical importance could be highlighted as followings: 1) The implant apical design influences the implant preliminary stability in immediate implant. The apical 3-5 mm design of implant makes implant stable in immediate implant, because this part would be screwed into alveolar bone through fresh socket, the other part of implant could not be tightly screwed in the socket because of smaller implant diameter...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326418/combining-a-hip-arthroplasty-stem-with-trochanteric-reattachment-bolt-and-a-polyaxial-locking-plate-in-the-treatment-of-a-periprosthetic-fracture-below-a-well-integrated-implant
#9
Urban Hedlundh, Lars Karlsson
Distally anchored uncemented modular tapered porous stems are often the preferred treatment in total hip arthroplasty revisions and failed subtrochanteric fractures. These conditions mainly affect elderly osteoporotic patients, with an increased risk of later fractures below the well-fixated implant. Treatment in secondary fractures with long looking plates is the recommended treatment, where stability is a key to fracture healing. We report a complicated case in which this was achieved by an innovative technique combing the trochanteric attachment bolt of the stem system and a locking plate with polyaxial screws...
December 2016: Arthroplasty Today
https://www.readbyqxmd.com/read/28325667/early-lung-adenocarcinoma-in-mice-micro-computed-tomography-manifestations-and-correlation-with-pathology
#10
Lin Deng, Shi Man Xiao, Jin Wei Qiang, Yong Ai Li, Yu Zhang
Lung cancer is the most common fatal malignancy for both men and women and adenocarcinoma is the most common histologic type. Early diagnosis of lung cancer can significantly improve the survival rate of patients. This study aimed to investigate the micro-computed tomography (micro-CT) manifestations of early lung adenocarcinoma (LAC) in mice and to provide a new perspective for early clinical diagnosis. Early LAC models in 10 mice were established by subcutaneously injecting 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) solution...
March 15, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28325366/whorling-cellular-perineurioma-a-previously-undescribed-variant-closely-mimicking-monophasic-fibrous-synovial-sarcoma
#11
Michael Michal, Dmitry V Kazakov, Abbas Agaimy, Marta Hosova, Kvetoslava Michalova, Petr Grossmann, Petr Steiner, Faruk Skenderi, Semir Vranic, Michal Michal
The authors present a distinctive perineurioma (PN) variant which morphologically strongly resembles monophasic fibrous synovial sarcoma (MSS). The patients were 3 males and 1 female. The age ranged from 15 to 61years (mean: 44years). Locations included the sole, lower jaw, palm and foot. The tumor size ranged from 1.3cm to 2.5cm in the largest dimension (mean 1.8cm). Morphologically, all tumors had an identical, monotonous appearance. The perineurial cells were closely packed and created a confluent cellular whorls and/or sheets in a scarce stroma, with only focally discernible long, slender cytoplasmic processes typical for perineurial differentiation...
April 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28323492/regulatory-and-exhausted-t-cell-responses-to-aav-capsid
#12
Gwladys Gernoux, James M Wilson, Christian Mueller
Recombinant adeno-associated viruses are quickly becoming the preferred viral vector for viral gene delivery for the treatment of a wide variety of genetic disorders. However, since their use in a clinical trial targeting Hemophilia B patients 10 years ago, immune responses to AAV capsid appear to have hampered some of the early clinical gene transfer efficacy. Indeed, AAV-based gene transfer has been shown to reactivate capsid-specific memory T cells which have correlated with a decline in AAV transduced tissue in some patients...
March 21, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28321964/combination-therapy-of-leflunomide-and-glucocorticoids-for-the-maintenance-of-remission-in-patients-with-igg4-related-disease-a-retrospective-study-and-literature-review
#13
Yiwen Wang, Kunpeng Li, Dai Gao, Gui Luo, Yurong Zhao, Xiuru Wang, Jie Zhang, Jingyu Jin, Zheng Zhao, Chunhua Yang, Jian Zhu, Jianglin Zhang, Feng Huang
BACKGROUND: Although glucocorticoids are effective in IgG4-related disease (IgG4-RD), patients may relapse during or after glucocorticoid tapering. Immunosuppressive agents including leflunomide (LEF) are regarded as steroid-sparing agents in other autoimmune disorders and need to be discussed in the management of IgG4-RD. AIM: To identify the efficacy and safety of combination therapy of LEF and glucocorticoids in IgG4-RD. METHODS: We retrospectively summarized data of patients diagnosed with IgG4-RD between November 2012 and November 2015...
March 21, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28321800/wear-of-morse-taper-and-external-hexagon-implant-joints-after-abutment-removal
#14
Abraão M Prado, Jorge Pereira, Filipe S Silva, Bruno Henriques, Rubens M Nascimento, Cesar A M Benfatti, José López-López, Júlio C M Souza
The aim of this in vitro study was to evaluate the removal torque values on abutments and the morphological wear aspects of two different dental implant joints after immersion in a medium containing biofilm from human saliva. Twenty implant-abutment assemblies were divided into four groups in this study: (A) Morse taper free of medium containing biofilm, and (B) after contact with a medium containing biofilm from human saliva; (C) External Hexagon free of medium containing biofilm, and (D) after contact with medium containing biofilm from human saliva...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28320139/10-year-outcomes-after-rituximab-for-myasthenia-gravis-efficacy-safety-costs-of-inhospital-care-and-impact-on-childbearing-potential
#15
Karl Stieglbauer, Robert Pichler, Raffi Topakian
Rituximab (RTX) has emerged as an attractive off-label treatment option for patients with myasthenia gravis (MG) refractory to other immune therapies. However, data on long-term outcome after RTX for MG are still scarce. Here we present the 10-year outcomes [median (range) 10.1 (6.7-11.2) years] with respect to efficacy, safety, costs of inhospital care, and impact on childbearing potential in all four MG patients treated by one of the authors with RTX. In all patients, RTX led to sustained clinical improvement and eventual tapering of other immune therapies...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319423/silexan-does-not-cause-withdrawal-symptoms-even-when-abruptly-discontinued
#16
M Gastpar, W E Müller, H P Volz, H J Möller, S Schläfke, A Dienel, S Kasper
OBJECTIVE: Subsequent to a randomised, double-blind, double dummy clinical trial assessing the efficacy of silexan compared to placebo and paroxetine in patients suffering from generalised anxiety disorder (GAD), a 1week follow-up phase was added in order to assess possible withdrawal symptoms of silexan after abrupt discontinuation. METHODS: Participants received silexan 80 mg/d, silexan 160 mg/d, paroxetine 20 mg/d, or placebo at a ratio of 1:1:1:1. Study medication was discontinued after the 10 week active treatment phase of the original trial...
March 20, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28318625/mycophenolate-mofetil-is-inferior-to-tacrolimus-in-sustaining-remission-in-children-with-idiopathic-steroid-resistant-nephrotic-syndrome
#17
Aditi Sinha, Aarti Gupta, Mani Kalaivani, Pankaj Hari, Amit K Dinda, Arvind Bagga
Studies of nephrotic syndrome show that substitution of calcineurin inhibitors by mycophenolate mofetil (MMF) enables sustained remission and corticosteroid sparing and avoids therapy associated adverse effects. However, controlled studies in patients with steroid resistance are lacking. Here we examined the effect of switching from therapy with tacrolimus to MMF on disease course in an open-label, one-to-one randomized, controlled trial on children (one to 18 years old), recently diagnosed with steroid-resistant nephrotic syndrome, at a referral center in India...
March 15, 2017: Kidney International
https://www.readbyqxmd.com/read/28316384/taxonomic-tools-for-the-identification-of-allogenarchopsisbareilliensis-n-sp-digenea-hemiuroidea-derogenidae-from-channastriata-of-rohilkhand-india-based-on-light-and-scanning-electron-microscopic-studies
#18
Neelima Gupta, Dileep K Gupta, Misako Urabe
The stomach of the freshwater snakehead murrel, Channastriata (n = 250) collected from fresh water habitats of Bareilly, Uttar Pradesh, India revealed Allogenarchopsis, a trematode parasite (Plagiorchiida: Derogenidae). An illustrated account of light (Olympus BX-53 with Cellsens software imaging system) and scanning electron microscopy (SEM) (Neo JCM-6000) of Allogenarchopsisbareilliensis n. sp. (prevalence 37 %, intensity 1-4 par/host) is provided. Light microscopy based studies warranting creation of a new species are the robust shape of the body with broad mid-body, blunt anterior and tapering posterior end, large ventral sucker, ratio of oral sucker: ventral sucker 1:3...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28314744/randomised-controlled-trial-comparing-ofatumumab-to-rituximab-in-children-with-steroid-dependent-and-calcineurin-inhibitor-dependent-idiopathic-nephrotic-syndrome-study-protocol
#19
Pietro Ravani, Alice Bonanni, Gian Marco Ghiggeri
INTRODUCTION: Oral steroids induce remission in about 90% of children with idiopathic nephrotic syndrome (INS), which is characterised by severe proteinuria and hypoalbuminaemia. Some children become steroid-dependent (SD) and require addition of calcineurin inhibitors (CNI) to maintain remission. Since these oral agents are toxic, alternative interventions are needed for long-term treatment. The anti-CD20 antibody rituximab has shown promising steroid-sparing properties in clinical trials, but benefits are less convincing in complicated forms of SD-INS...
March 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28303301/impact-of-tapered-cuff-tracheal-tube-on-microaspiration-of-gastric-contents-in-intubated-critically-ill-patients-a-multicenter-cluster-randomized-cross-over-controlled-trial
#20
Emmanuelle Jaillette, Christophe Girault, Guillaume Brunin, Farid Zerimech, Hélène Behal, Arnaud Chiche, Céline Broucqsault-Dedrie, Cyril Fayolle, Franck Minacori, Isabelle Alves, Stéphanie Barrailler, Julien Labreuche, Laurent Robriquet, Fabienne Tamion, Emmanuel Delaporte, Damien Thellier, Claire Delcourte, Alain Duhamel, Saad Nseir
PURPOSE: Studies on the impact of tapered-cuff tracheal tubes on rates of microaspiration and ventilator-associated pneumonia (VAP) in intubated patients have reported conflicting results. The aim of this study was to determine the influence of this shape of tracheal cuff on abundant microaspiration of gastric contents in critically ill patients. METHODS: All patients intubated in the intensive care unit (ICU) and requiring mechanical ventilation for at least 48 h were eligible for this multicenter cluster-randomized controlled cross-over open-label study...
March 16, 2017: Intensive Care Medicine
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