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https://www.readbyqxmd.com/read/29774135/vemurafenib-in-langerhans-cell-histiocytosis-report-of-a-pediatric-patient-and-review-of-the-literature
#1
Anne Heisig, Jan Sörensen, Stefanie-Yvonne Zimmermann, Stefan Schöning, Dirk Schwabe, Hans-Michael Kvasnicka, Raphaela Schwentner, Caroline Hutter, Thomas Lehrnbecher
Selective BRAF inhibitors such as vemurafenib have become a treatment option in patients with Langerhans cell Histiocytosis (LCH). To date, only 14 patients receiving vemurafenib for LCH have been reported. Although vemurafenib can stabilize the clinical condition of these patients, it does not seem to cure the patients, and it is unknown, when and how to stop vemurafenib treatment. We present a girl with severe multisystem LCH who responded only to vemurafenib. After 8 months of treatment, vemurafenib was tapered and replaced by prednisone and vinblastine, a strategy which has not been described to date...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773267/update-on-research-and-clinical-translation-on-specific-clinical-areas-from-biology-to-bedside-unpacking-the-mysteries-of-juvenile-idiopathic-arthritis-pathogenesis
#2
REVIEW
Jorg van Loosdregt, Femke van Wijk, Berent Prakken, Bas Vastert
In the past decades, we have gained important insights into the mechanisms of disease and therapy underlying chronic inflammation in juvenile idiopathic arthritis (JIA). These insights have resulted in several game-changing therapeutic modalities for many patients. However, additional progress still has to be made with regard to efficacy, cost reduction, minimization of side effects, and dose-tapering and stop strategies of maintenance drugs. Moreover, to really transform the current therapeutic strategies into personalized medicine, we need validated biomarkers to translate increased insights into clinical practice...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29771118/escherichia-coli-fiber-sensors-using-concentrated-dielectrophoretic-force-with-optical-defocusing-method
#3
Yi-Hsin Tai, Chia-Wei Lee, Dao-Ming Chang, Yu-Sheng Lai, Ding-Wei Huang, Pei-Kuen Wei
A sensitive tapered optical fiber tip combined with dielectrophoretic (DEP) trapping was used to rapid and label-free detection of bacteria in water. The angular spectrum of optical field at the fiber tip was changed with surrounding refractive index (RI). By measuring far-field intensity change at the defocus plane, the intensity sensitivity was up to 95,200 %/RIU (RI unit) and the detection limit was 2.1 × 10-6 RIU at 0.2% intensity stability. By applying an AC voltage to a Ti/Al coated fiber tip and an indium-tin-oxide glass, the DEP force effectively trapped the Escherichia coli (E...
May 17, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29769767/a-comparative-study-on-the-stress-distribution-around-dental-implants-in-three-arch-form-models-for-replacing-six-implants-using-finite-element-analysis
#4
Maryam Zarei, Mahmoud Jahangirnezhad, Hojatollah Yousefimanesh, Maryam Robati, Hossein Robati
Background: Dental implant is a method to replacement of missing teeth. It is important for replacing the missed anterior teeth. In vitro method is a safe method for evaluation of stress distribution. Finite element analysis as an in vitro method evaluated stress distribution around replacement of six maxillary anterior teeth implants in three models of maxillary arch. Materials and Methods: In this in vitro study, using ABAQUS software (Simulia Corporation, Vélizy-Villacoublay, France), implant simulation was performed for reconstruction of six maxillary anterior teeth in three models...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29767318/strategies-for-effective-discontinuation-of-proton-pump-inhibitors
#5
REVIEW
Judith Kim, John W Blackett, Daniela Jodorkovsky
PURPOSE OF REVIEW: Proton pump inhibitors (PPIs) are effective for many conditions but are often overprescribed. Recent concerns about long-term risks have made patients re-evaluate their need to take PPIs chronically, though these population-based studies have methodological weaknesses. The goal of this review is to provide evidenced-based strategies for discontinuation of PPI therapy. RECENT FINDINGS: Given that some patients experience rebound symptoms when abruptly stopping continuous PPI therapy due to its effect on hypergastrinemia, strategies focus on avoiding rebound...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29766338/an-unusual-surgical-indication-for-cerebral-tuberculosis-status-dystonicus-case-report
#6
Andrea Franzini, Angelo Franzini, Vincenzo Levi, Roberto Cordella, Giuseppe Messina
Actual indications for surgery in tuberculosis are limited to obtaining a diagnosis, acquiring tissue for culture studies, treating hydrocephalus, aspiring a brain abscess, and reducing intracranial pressure in patients with multiple tuberculomas. Tuberculosis-related movement disorders are usually treated pharmacologically. We report on a child affected by post-tubercular generalized dystonia, who progressed to status dystonicus (SD) and underwent stereotactic bilateral pallidotomy. After surgery, SD resolved, and drugs were rapidly tapered...
May 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29766202/photochemical-device-for-selective-detection-of-phenol-in-aqueous-solutions
#7
Nianbing Zhong, Ming Chen, Zhengkun Wang, Xin Xin, Bingxin Li
We demonstrate that a lab-on-a-chip device (hereafter termed a photochemical phenol sensor) that integrates a photocatalytic long-period fiber grating (PLPFG), fiber Bragg grating (FBG), polymer membrane, ultraviolet (UV) visible light, and microchannels can be exploited to selectively detect phenol in aqueous solutions. The novel PLPFG consisted of a thinned long-period fiber grating (LPFG) and a UV-visible-light-driven Er3+:YAlO3/SiO2/TiO2 (EYST) coating. The polymer membrane with high phenol permselectivity was synthesized using PEBA2533 doped with β-cyclodextrin and was wrapped around the EYST surface, thus forming a microchannel between the membrane and PLPFG to enable the injection and outflow of standard analytes...
May 16, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29765868/retrobulbar-steatitis-and-meningitis-empyema-secondary-to-right-otitis-media-right-otitis-interna-and-an-inflammatory-polyp-in-a-cat
#8
Elena Fenollosa-Romero, Olivier Taeymans, Pieter Nelissen, Giunio B Cherubini, Claudia Busse
The purpose was to describe a case of retrobulbar steatitis and meningitis in a cat caused by otitis media, otitis interna and an inflammatory polyp in the middle ear. Investigations included ophthalmic and neurological examinations, haematology and biochemistry, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis and aerobic, anaerobic bacterial and fungal culture of material from the middle ear. A 6-year-old female neutered domestic-short-haired cat presented with right-sided exophthalmos and resistance to retropulsion...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29765689/a-new-archaic-baleen-whale-toipahautea-waitaki-early-late-oligocene-new-zealand-and-the-origins-of-crown-mysticeti
#9
Cheng-Hsiu Tsai, R Ewan Fordyce
A new genus and species of extinct baleen whale † Toipahautea waitaki (Late Oligocene, New Zealand) is based on a skull and associated bones, from the lower Kokoamu Greensand, about 27.5 Ma (local upper Whaingaroan Stage, early Chattian). The upper jaw includes a thin, elongate and apparently toothless maxilla, with evidence of arterial supply for baleen. Open sutures with the premaxilla suggest a flexible (kinetic) upper jaw. The blowhole is well forward. The mandible is bowed laterally and slightly dorsally; unlike the Eomysticetidae, there are no mandibular alveoli, and the coronoid process is tapered and curved laterally...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29764780/what-is-the-required-frequency-of-mri-scanning-in-the-wait-and-scan-management
#10
Thomas Somers, Romain Kania, Jerome Waterval, Tony Van Havenbergh
The wait and scan policy is being increasingly used as the first measure after the diagnosis of a vestibular schwannoma (VS) using magnetic resonance imaging (MRI). As part of the European Academy of Otology and Neuro-Otology (EAONO) position statement on VS, the frequency of imaging has been studied in the literature. Among 163 studies, 29 fulfilled the inclusion criteria and were scored using the Grading of Recommendations, Assessment, Development, and Evaluation system. Because tumor growth rate during the first 5 years of follow-up is predictive of further growth during the upcoming years, a protocol for wait and scan is useful for centers dealing with this condition...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29763343/clinical-and-patient-related-outcomes-of-a-tapered-implant-system-with-switched-platform-conical-abutments-a-private-practice-field-trial
#11
Jacob Horwitz, Eli E Machtei, Shai Frankental, Eran Gabay, Yaniv Mayer, Livia Joseph, Omer Cohen
The aim of this prospective cohort observational field trial was to examine 1-year survival and success rates of a recently introduced tapered implant system with switched platform conical abutments and to evaluate patient related outcomes of therapy. Partially edentulous patients aged between 18-75, with available bone height for dental implants ≥ 10mm mm. desiring to restore the missing tooth/teeth with implant supported restoration, were recruited by seven periodontists in their respective private practices...
May 15, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29762582/dispersion-tuning-in-sub-micron-tapers-for-third-harmonic-and-photon-triplet-generation
#12
Jonas Hammer, Andrea Cavanna, Riccardo Pennetta, Maria V Chekhova, Philip St J Russell, Nicolas Y Joly
Precise control of the dispersion landscape is of crucial importance if optical fibers are to be successfully used for the generation of three-photon states of light-the inverse of third-harmonic generation (THG). Here we report gas-tuning of intermodal phase-matched THG in sub-micron-diameter tapered optical fiber. By adjusting the pressure of the surrounding argon gas up to 50 bars, intermodally phase-matched third-harmonic light can be generated for pump wavelengths within a 15 nm range around 1.38 μm...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29762184/histomorphometric-comparison-of-3-osteotomy-techniques
#13
Frederic B Slete, Paul Olin, Hari Prasad
PURPOSE: This pilot study compares the histomorphometric structure of osteotomy preparation through standard extraction drilling (SD), Summers osteotomes (SO), and a new method of nonextraction drilling called osseodensification (OD). METHOD AND MATERIALS: Fresh porcine tibia plateau was used as the surgical specimen. Three preparation methods (N = 6 for each) were used to prepare 18 osteotomies according to manufacturer protocols. Eighteen tapered screw-vent (4...
May 14, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29761902/the-influence-of-implant-abutment-connection-to-peri-implant-bone-loss-a-systematic-review-and-meta-analysis
#14
REVIEW
Riccardo Caricasulo, Luciano Malchiodi, Paolo Ghensi, Giuliano Fantozzi, Alessandro Cucchi
PURPOSE: Different implant-abutment connections are available and it has been claimed they could have an effect on marginal bone loss. The aim of this review is to establish if implant connection configuration influences peri-implant bone loss (PBL) after functional loading. METHODS: A specific question was formulated according to the Population, Intervention, Control, and Outcome (PICO): Does the type of implant-abutment connection (external, internal, or conical) have an influence on peri-implant bone loss? A PubMed/MEDLINE electronic search was conducted to identify English language publications published in international journals during the last decade (from 2006 to 2016)...
May 15, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29761846/stability-of-tapered-and-parallel-walled-dental-implants-a-systematic-review-and-meta-analysis
#15
REVIEW
Momen A Atieh, Nabeel Alsabeeha, Warwick J Duncan
BACKGROUND: Clinical trials have suggested that dental implants with a tapered configuration have improved stability at placement, allowing immediate placement and/or loading. The aim of this systematic review and meta-analysis was to evaluate the implant stability of tapered dental implants compared to standard parallel-walled dental implants. MATERIALS AND METHODS: Applying the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, randomized controlled trials (RCTs) were searched for in electronic databases and complemented by hand searching...
May 15, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29761026/conservative-management-of-nivolumab-induced-pericardial-effusion-a-case-report-and-review-of-literature
#16
Shagufta Shaheen, Hamid Mirshahidi, Gayathri Nagaraj, Chung-Tsen Hsueh
Background: Nivolumab is an immune checkpoint inhibitor targeting programmed death-1 protein and has been approved for the treatment of multiple advanced malignancies. Adverse effects of immune checkpoint inhibitors are distinct from conventional cytotoxic chemotherapy and can be life-threatening if left unrecognized. Here, we present a case of nivolumab-induced pericardial effusion successfully managed with high-dose corticosteroids. Case presentation: A 70-year-old Caucasian female with a history of 50-pack-year cigarette smoking was diagnosed of recurrent adenocarcinoma of lung after initial surgery...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29760253/deprescribing-benzodiazepine-receptor-agonists-evidence-based-clinical-practice-guideline
#17
Kevin Pottie, Wade Thompson, Simon Davies, Jean Grenier, Cheryl A Sadowski, Vivian Welch, Anne Holbrook, Cynthia Boyd, Robert Swenson, Andy Ma, Barbara Farrell
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper and stop benzodiazepine receptor agonists (BZRAs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. METHODS: The overall team comprised 8 clinicians (1 family physician, 2 psychiatrists, 1 clinical psychologist, 1 clinical pharmacologist, 2 clinical pharmacists, and 1 geriatrician) and a methodologist; members disclosed conflicts of interest...
May 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29759276/hypnotic-discontinuation-in-chronic-insomnia
#18
REVIEW
Jonathan P Hintze, Jack D Edinger
Patients with chronic insomnia are commonly prescribed hypnotic medications. The long-term effects of chronic hypnotics are not known and discontinuation is encouraged but often difficult to achieve. A gradual taper is preferred to abrupt cessation to avoid rebound insomnia and withdrawal symptoms. Written information provided to the patient about medication discontinuation may be helpful. Cognitive behavioral therapy or behavioral therapies alone can improve hypnotic discontinuation outcomes. There is limited evidence for adjunct medications to assist in hypnotic cessation for insomnia...
June 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29759126/primary-care-vasculitis-polymyalgia-rheumatica-and-giant-cell-arteritis
#19
REVIEW
Mathilde H Pioro
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory diseases of adults aged 50 years or older. The diagnosis of PMR is based on morning stiffness, proximal shoulder and pelvic girdle pain, and functional impairment. GCA is characterized by headache, jaw claudication, and visual disturbances. Constitutional symptoms and elevated inflammatory markers are common to both conditions. Temporal artery biopsy remains the gold standard for diagnosis of GCA. Glucocorticoids are the cornerstone of therapy, with tapering regimens individualized to the patient...
June 2018: Primary Care
https://www.readbyqxmd.com/read/29756511/surface-integrity-of-polyethylene-liners-following-trunnionosis-of-a-dual-modular-neck-total-hip-implant
#20
Ben Gi Spiegelberg, Brent A Lanting, James L Howard, Matthew G Teeter, Douglas Dr Naudie
BACKGROUND: There has been a trend in the evolution of total hip arthroplasty towards increased modularity; with this increase in modularity come some potentially harmful consequences. Modularity at the neck shaft junction has been linked to corrosion, adverse reaction to metal debris and pseudotumour formation. AIM: The aim of this retrieval study is to assess whether the surface integrity of the polyethylene (PE) liner is affected by metal wear debris in a single implant design series of THA revised for trunnionosis...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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