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https://www.readbyqxmd.com/read/29040949/phenomenological-characteristics-of-recovered-memory-in-nonclinical-individuals
#1
Chui-De Chiu
A central hypothesis of recovered memory is that the source of the memory may be misattributed, and the memory of an imagined event may be mistaken as the memory of the perceived event that was not remembered. The judgment of memory source depends upon phenomenological characteristics. Thus, the present study investigated characteristics of recovered memory. To exclude potential confounding effects of traumatic stress and acute mental illness, data on recovered memories of diverse valences in a nonclinical sample were collected...
October 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29040828/neuropsychological-functioning-and-brain-energetics-of-drug-resistant-mesial-temporal-lobe-epilepsy-patients
#2
Camila Moreira Osório, Alexandra Latini, Rodrigo Bainy Leal, Maria Emília Rodrigues de Oliveira Thais, Helena Dresch Vascouto, Aline Pertile Remor, Mark William Lopes, Marcelo Neves Linhares, Juliana Ben, Roberta de Paula Martins, Rui Daniel Prediger, Alexandre Ademar Hoeller, Hans Joachim Markowitsch, Peter Wolf, Kátia Lin, Roger Walz
Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n=21), surgically treated patients with MTLE-HS (n=32, left side=17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency...
October 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29040807/photochemical-control-over-oscillations-in-chemical-reaction-networks
#3
Aleksandr A Pogodaev, Albert S Y Wong, Wilhelm T S Huck
Systems chemistry aims to emulate the functional behavior observed in living systems by constructing chemical reaction networks (CRNs) with well-defined dynamic properties. Future expansion of the complexity of these systems would require external control to tune behavior and temporal organization of such CRNs. In this work, we design and implement a photolabile probe, which upon irradiation strengthens the negative feedback loop of a CRN that produces oscillations of trypsin under out-of-equilibrium conditions...
October 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29040785/engineering-a-temperature-sensitive-tobacco-etch-virus-protease
#4
J Wong, X Chen, K Truong
Since tobacco etch virus protease (TEVp) has a high specificity and efficiency in cleaving its target substrates, many groups have attempted to engineer conditional control of its activity. Temperature induction is widely used for modulating gene function because it has fast temporal response, good penetrability and applicability to many model organisms. Here, we engineered a temperature sensitive TEVp (tsTEVp) by using N-terminal truncations to TEVp that achieved efficient proteolysis on a timescale of 4 h after 30°C induction, while remaining relatively inactive at 37°C...
October 13, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29040752/expansion-of-the-dehydrin-gene-family-in-the-pinaceae-is-associated-with-considerable-structural-diversity-and-drought-responsive-expression
#5
Juliana Stival Sena, Isabelle Giguère, Philippe Rigault, Jean Bousquet, John Mackay
Temperatures are expected to increase over the next century in all terrestrial biomes and particularly in boreal forests, where drought-induced mortality has been predicted to rise. Genomics research is helping to develop hypotheses regarding the molecular basis of drought tolerance and recent work proposed that the osmo-protecting dehydrin proteins have undergone a clade-specific expansion in the Pinaceae, a major group of conifer trees. The objectives of this study were to identify all of the putative members of the gene family, trace their evolutionary origin, examine their structural diversity and test for drought-responsive expression...
October 13, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29040743/anger-sensitive-networks-characterising-neural-systems-recruited-during-aggressive-social-interactions-using-data-driven-analysis
#6
Frederike Beyer, Ulrike M Krämer, Christian F Beckmann
Social neuroscience uses increasingly complex paradigms to improve ecological validity, as investigating aggressive interactions with functional magnetic resonance imaging (fMRI; Krämer, Jansma, Tempelmann, & Münte, 2007). Standard analyses for fMRI data typically use general linear models (GLM), which require a priori models of task effects on neural processes. These may inadequately model non-stimulus-locked or temporally overlapping cognitive processes, as mentalizing about other agents.We used the data-driven approach of independent component analysis (ICA) to investigate neural processes involved in a competitive interaction...
October 4, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29040723/resting-state-functional-connectivity-in-combat-veterans-suffering-from-impulsive-aggression
#7
T Varkevisser, T E Gladwin, L Heesink, J van Honk, E Geuze
Impulsive aggression is common amongst military personnel after deployment, and may arise because of impaired top-down regulation of the amgydala by prefrontal regions. This study sought to further explore this hypothesis via resting-state functional connectivity analyses in impulsively aggressive combat veterans. Male combat veterans with (n = 28) and without (n = 30) impulsive aggression problems underwent resting-state fMRI. Functional connectivity analyses were conducted with the following seed-regions: basolateral amygdala (BLA), centromedial amygdala (CeM), anterior cingulate cortex (ACC), and anterior insular cortex (AIC)...
October 12, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29040672/unsupervised-learning-of-spatiotemporal-interictal-discharges-in-focal-epilepsy
#8
Maxime O Baud, Jonathan K Kleen, Gopala K Anumanchipalli, Liberty S Hamilton, Yee-Leng Tan, Robert Knowlton, Edward F Chang
BACKGROUND: Interictal epileptiform discharges are an important biomarker for localization of focal epilepsy, especially in patients who undergo chronic intracranial monitoring. Manual detection of these pathophysiological events is cumbersome, but is still superior to current rule-based approaches in most automated algorithms. OBJECTIVE: To develop an unsupervised machine-learning algorithm for the improved, automated detection and localization of interictal epileptiform discharges based on spatiotemporal pattern recognition...
October 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29040596/high-fidelity-phenotyping-richness-and-freedom-from-bias
#9
George Hripcsak, David J Albers
Electronic health record phenotyping is the use of raw electronic health record data to assert characterizations about patients. Researchers have been doing it since the beginning of biomedical informatics, under different names. Phenotyping will benefit from an increasing focus on fidelity, both in the sense of increasing richness, such as measured levels, degree or severity, timing, probability, or conceptual relationships, and in the sense of reducing bias. Research agendas should shift from merely improving binary assignment to studying and improving richer representations...
October 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040587/does-low-to-moderate-environmental-exposure-to-noise-and-air-pollution-influence-preterm-delivery-in-medium-sized-cities
#10
Marie Barba-Vasseur, Nadine Bernard, Sophie Pujol, Paul Sagot, Didier Riethmuller, Gérard Thiriez, Hélène Houot, Jérôme Defrance, Anne-Sophie Mariet, Vinh-Phuc Luu, Alice Barbier, Eric Benzenine, Catherine Quantin, Frédéric Mauny
Background: Preterm birth (PB) is an important predictor of childhood morbidity and educational performance. Beyond the known risk factors, environmental factors, such as air pollution and noise, have been implicated in PB. In urban areas, these pollutants coexist. Very few studies have examined the effects of multi-exposure on the pregnancy duration. The objective of this study was to analyse the relationship between PB and environmental chronic multi-exposure to noise and air pollution in medium-sized cities...
July 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040472/optogenetic-modulation-of-a-minor-fraction-of-parvalbumin-positive-interneurons-specifically-affects-spatiotemporal-dynamics-of-spontaneous-and-sensory-evoked-activity-in-mouse-somatosensory-cortex-in-vivo
#11
Jenq-Wei Yang, Pierre-Hugues Prouvot, Vicente Reyes-Puerta, Maik C Stüttgen, Albrecht Stroh, Heiko J Luhmann
Parvalbumin (PV) positive interneurons exert strong effects on the neocortical excitatory network, but it remains unclear how they impact the spatiotemporal dynamics of sensory processing in the somatosensory cortex. Here, we characterized the effects of optogenetic inhibition and activation of PV interneurons on spontaneous and sensory-evoked activity in mouse barrel cortex in vivo. Inhibiting PV interneurons led to a broad-spectrum power increase both in spontaneous and sensory-evoked activity. Whisker-evoked responses were significantly increased within 20 ms after stimulus onset during inhibition of PV interneurons, demonstrating high temporal precision of PV-shaped inhibition...
October 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29040412/random-recurrent-networks-near-criticality-capture-the-broadband-power-distribution-of-human-ecog-dynamics
#12
Rishidev Chaudhuri, Biyu J He, Xiao-Jing Wang
Brain electric field potentials are dominated by an arrhythmic broadband signal, but the underlying mechanism is poorly understood. Here we propose that broadband power spectra characterize recurrent neural networks of nodes (neurons or clusters of neurons), endowed with an effective balance between excitation and inhibition tuned to keep the network on the edge of dynamical instability. These networks show a fast mode reflecting local dynamics and a slow mode emerging from distributed recurrent connections...
October 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29040409/towards-dynamic-genome-scale-models
#13
David Gilbert, Monika Heiner, Yasoda Jayaweera, Christian Rohr
The analysis of the dynamic behaviour of genome-scale models of metabolism (GEMs) currently presents considerable challenges because of the difficulties of simulating such large and complex networks. Bacterial GEMs can comprise about 5000 reactions and metabolites, and encode a huge variety of growth conditions; such models cannot be used without sophisticated tool support. This article is intended to aid modellers, both specialist and non-specialist in computerized methods, to identify and apply a suitable combination of tools for the dynamic behaviour analysis of large-scale metabolic designs...
October 13, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29040403/age-related-changes-in-temporal-processing-of-rapidly-presented-sound-sequences-in-the-macaque-auditory-cortex
#14
Ng Chi-Wing, Gregg H Recanzone
The mammalian auditory cortex is necessary to resolve temporal features in rapidly-changing sound streams. This capability is crucial for speech comprehension in humans and declines with normal aging. Nonhuman primate studies have revealed detrimental effects of normal aging on the auditory nervous system, and yet the underlying influence on temporal processing remains less well-defined. Therefore, we recorded from the core and lateral belt areas of auditory cortex when awake young and old monkeys listened to tone-pip and noise-burst sound sequences...
October 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29040398/correlation-of-blood-pressure-variability-as-measured-by-clinic-self-measurement-at-home-and-ambulatory-blood-pressure-monitoring
#15
J Abellán-Huerta, L Prieto-Valiente, S Montoro-García, J Abellán-Alemán, F Soria-Arcos
Background: Blood pressure variability (BPV) has been postulated as a potential predictor of cardiovascular outcomes. No agreement exists as to which measurement method is best for BPV estimation. We attempt to assess the correlation between BPV obtained at the doctor's office, self-measurement at home (SMBP) and ambulatory BP monitoring (ABPM). Methods: Eight weekly clinic BP measurements, two SMBP series and one 24-hour ABPM recording were carried out in a sample of treated hypertensive patients...
October 10, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29040393/extending-the-scope-of-darwin-s-abominable-mystery-integrative-approaches-to-understanding-angiosperm-origins-and-species-richness
#16
Ofir Katz
Background and aims: Angiosperms are the most species-rich group of land plants, but their origins and fast and intense diversification still require an explanation. Scope: Extending research scopes can broaden theoretical frameworks and lines of evidence that can lead to solving this 'abominable mystery'. Solutions lie in understanding evolutionary trends across taxa and throughout the Phanerozoic, and integration between hypotheses and ideas that are derived from multiple disciplines...
October 10, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29040382/generalized-correlation-measure-using-count-statistics-for-gene-expression-data-with-ordered-samples
#17
Y X Rachel Wang, Ke Liu, Elizabeth Theusch, Jerome I Rotter, Marisa W Medina, Michael S Waterman, Haiyan Huang
Motivation: Capturing association patterns in gene expression levels under different conditions or time points is important for inferring gene regulatory interactions. In practice, temporal changes in gene expression may result in complex association patterns that require more sophisticated detection methods than simple correlation measures. For instance, the effect of regulation may lead to time-lagged associations and interactions local to a subset of samples. Furthermore, expression profiles of interest may not be aligned or directly comparable (e...
October 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040319/habitat-selection-and-diurnal-refugia-of-gray-foxes-in-southwestern-georgia-usa
#18
Nicholas R Deuel, L Mike Conner, Karl V Miller, Michael J Chamberlain, Michael J Cherry, Larry V Tannenbaum
Understanding habitat selection of gray foxes (Urocyon cinereoargenteus) is essential to evaluate their potential response to changes in land use and predator communities. Few studies have evaluated temporal habitat selection or explicitly identified habitats used by gray foxes for diurnal refugia. We used GPS collars to obtain location data for 34 gray foxes (20 males and 14 females) from February 2014 to December 2015 to evaluate temporal (seasonal and diel) habitat selection and selection of diurnal refugia in southwestern Georgia, USA...
2017: PloS One
https://www.readbyqxmd.com/read/29040203/the-temporal-response-and-mechanism-of-action-of-tranexamic-acid-in-endothelial-glycocalyx-degradation
#19
Mark E Diebel, Jonathan V Martin, David M Liberati, Lawrence N Diebel
BACKGROUND: The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress related sympathoadrenal activation, and inflammation. Tranexamic acid (TXA) may prevent GCX degradation. The therapeutic window for TXA administration and the mechanism of action has been under review. Membrane-anchored proteases (sheddases) are key components in endothelial cell biology including the regulation of vascular permeability...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29040115/keratitis-after-post-kala-azar-dermal-leishmaniasis
#20
Aditya Pradhan, Samar Basak, Tuhin Chowdhury, Ayan Mohanta, Ananya Chatterjee
PURPOSE: To report 2 cases of keratitis occurring after post-kala-azar dermal leishmaniasis (PKDL) in immunocompetent patients. METHODS: Case report and literature review. RESULTS: Two male patients presented with a dense stromal infiltrate in the temporal and superior aspects of the cornea, respectively. Microbiological workup in both patients did not show any offending organism. Both patients were undergoing treatment for PKDL in the form of oral miltefosine...
October 13, 2017: Cornea
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