keyword
MENU ▼
Read by QxMD icon Read
search

Temporal

keyword
https://www.readbyqxmd.com/read/29668112/pharmacogenetic-manipulation-of-the-nucleus-accumbens-alters-binge-like-alcohol-drinking-in-mice
#1
Kush Purohit, Puja K Parekh, Joseph Kern, Ryan W Logan, Zheng Liu, Yanhua Huang, Colleen A McClung, John C Crabbe, Angela R Ozburn
BACKGROUND: Chronic alcohol intake leads to long-lasting changes in reward- and stress-related neuronal circuitry. The nucleus accumbens (NAc) is an integral component of this circuitry. Here, we investigate the effects of DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) on neuronal activity in the NAc and binge-like drinking. METHODS: C57BL/6J mice were stereotaxically injected with AAV2 hSyn-HA hM3Dq, -hM4Di, or -eGFP bilaterally into NAc [core + shell, core or shell]...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29668059/v-reasoning-about-side-effects-influences-of-temporal-and-spatial-expectations
#2
Kristi L Lockhart, Frank C Keil
No abstract text is available yet for this article.
June 2018: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/29668058/i-introduction-understanding-medicines-and-medical-interventions
#3
Kristi L Lockhart, Frank C Keil
We live in an increasingly pharmacological and medical world, where children and adults frequently encounter alleged treatments for an enormous range of illnesses. How do we come to understand what heals and why? Here, 15 studies explore how 1,414 children (ages 5-11) and 882 adults construe the efficacies of different kinds of cures. Developmental patterns in folk physics, psychology, and biology lead to predictions about which expectations about cures will remain relatively constant across development and which will change...
June 2018: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/29668049/surgical-management-of-spontaneous-cerebrospinal-fistulas-and-encephaloceles-of-the-temporal-bone
#4
Joe Walter Kutz, Andrew K Johnson, Cameron C Wick
OBJECTIVES/HYPOTHESIS: To describe the presentation, surgical findings, and outcomes in patients with spontaneous temporal bone cerebrospinal fluid (CSF) fistulas and encephaloceles. STUDY DESIGN: Retrospective chart review. METHODS: A retrospective chart review of patients treated for a spontaneous temporal bone CSF fistula and/or encephalocele over a 10-year period was performed. Data recorded included demographic information, presenting signs and symptoms, radiographic and laboratory studies, surgical approach, materials used for repair, surgical complications, and successful closure of the CSF fistula...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668002/a-sharp-edge-based-acoustofluidic-chemical-signal-generator
#5
Po-Hsun Huang, Chung Yu Chan, Peng Li, Yuqi Wang, Nitesh Nama, Hunter Bachman, Tony Jun Huang
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these signaling pathways requires the exposure of cells to time-varying chemical signals; these are difficult to generate and control over a wide temporal range. Herein, we present an acoustofluidic chemical signal generator based on a sharp-edge-based micromixing strategy. The device, simply by modulating the driving signals of an acoustic transducer including the ON/OFF switching frequency, actuation time and duty cycle, is capable of generating both single-pulse and periodic chemical signals that are temporally controllable in terms of stimulation period, stimulation duration and duty cycle...
April 18, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29667836/molecular-dynamics-simulations-are-redefining-our-view-of-peptides-interacting-with-biological-membranes
#6
Jakob P Ulmschneider, Martin B Ulmschneider
Ever since the first molecular mechanics computer simulations of biological molecules became possible, there has been the dream to study all complex biological phenomena in silico, simply bypassing the enormous experimental challenges and their associated costs. For this, two inherent requirements need to be met: First, the time scales achievable in simulations must reach up to the millisecond range and even longer. Second, the computational model must accurately reproduce what is measured experimentally. Despite some recent successes, the general consensus in the field to date has been that neither of these conditions have yet been met and that the dream will be realized, if at all, only in the distant future...
April 18, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#7
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29667686/rheological-characterization-of-dynamic-remodeling-of-the-pericellular-region-by-human-mesenchymal-stem-cell-secreted-enzymes-in-well-defined-synthetic-hydrogel-scaffolds
#8
Maryam Daviran, Sarah M Longwill, Jonah F Casella, Kelly M Schultz
Human mesenchymal stem cells (hMSCs) dynamically remodel their microenvironment during basic processes, such as migration and differentiation. Migration requires extracellular matrix invasion, necessitating dynamic cell-material interactions. Understanding these interactions is critical to advancing materials designs that harness and manipulate these processes for applications including wound healing and tissue regeneration. In this work, we encapsulate hMSCs in a cell-degradable poly(ethylene glycol)-peptide hydrogel to determine how cell-secreted enzymes, specifically matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), create unique pericellular microenvironments...
April 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29667563/development-of-stop-consonants-in-three-to-six-year-old-mandarin-speaking-children
#9
Jing Yang
This study compared the temporal measurements of stop consonants in 29 three- to six-year-old Mandarin-speaking children and 12 Mandarin-speaking adults. Each participant produced 18 Mandarin disyllabic words which contained six stop consonants /p, pʰ, t, tʰ, k, kʰ/ each followed by three vowels /a, i, u/ at the word-initial position in the first syllable. The temporal measurements of VOT, overall burst duration, average duration per burst, number of bursts, and VOT-lag duration were obtained. Although adult-like short-lag VOTs were achieved in all children, the long-lag VOTs were widespread in the younger group and gradually developed to a concentrated distribution in the older children...
April 18, 2018: Journal of Child Language
https://www.readbyqxmd.com/read/29667491/optimization-of-3d-print-material-for-the-recreation-of-patient-specific-temporal-bone-models
#10
Max Haffner, Austin Quinn, Tsung-Yen Hsieh, E Bradley Strong, Toby Steele
OBJECTIVE: Identify the 3D printed material that most accurately recreates the visual, tactile, and kinesthetic properties of human temporal bone Subjects and Methods: Fifteen study participants with an average of 3.6 years of postgraduate training and 56.5 temporal bone (TB) procedures participated. Each participant performed a mastoidectomy on human cadaveric TB and five 3D printed TBs of different materials. After drilling each unique material, participants completed surveys to assess each model's appearance and physical likeness on a Likert scale from 0 to 10 (0 = poorly representative, 10 = completely life-like)...
May 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29667465/association-of-serum-specific-ige-levels-with-asthma-in-autumn-pollen-induced-allergic-rhinitis-a-retrospective-analysis
#11
Le Cui Md, Jia Yin Md
BACKGROUND: Artemisia and Humulus pollen are the two most important aeroallergens of autumn allergies in North China. Cross-sectional data in 2001 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients with autumn pollinosis in North China. OBJECTIVE: We used this cross-sectional data to investigate the association of serum specific IgE (sIgE) levels to Humulus and/or Artemisia pollen with the onset of asthma in patients with autumn pollen-induced allergic rhinitis...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29667272/different-brain-networks-underlying-intelligence-in-autism-spectrum-disorders
#12
Emmanuel Peng Kiat Pua, Charles B Malpas, Stephen C Bowden, Marc L Seal
There has been sustained clinical and cognitive neuroscience research interest in how network correlates of brain-behavior relationships might be altered in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders. As previous work has mostly focused on adults, the nature of whole-brain connectivity networks underlying intelligence in pediatric cohorts with abnormal neurodevelopment requires further investigation. We used network-based statistics (NBS) to examine the association between resting-state functional Magnetic Resonance Imaging (fMRI) connectivity and fluid intelligence ability in male children (n = 50) with Autism Spectrum Disorders (ASD; M = 10...
April 17, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29667247/the-nuclear-factor-constans-complex-antagonizes-polycomb-repression-to-de-repress-flowering-locus-t-expression-in-response-to-inductive-long-days-in-arabidopsis
#13
Xiao Luo, Zheng Gao, Yizhong Wang, Zhijuan Chen, Wenju Zhang, Jirong Huang, Hao Yu, Yuehui He
Many plants sense the seasonal cues, day length or photoperiod changes, to align the timing of the developmental transition to flowering with changing seasons for reproductive success. Inductive day lengths through the photoperiod pathway induces the expression of FLOWERING LOCUS T (FT) or FT relatives that encode a major mobile florigen to promote flowering. In Arabidopsis thaliana, under inductive long days the photoperiod pathway output CONSTANS (CO) accumulates toward the end of the day and associates with the B and C subunits of Nuclear Factor Y (NF-Y) to form the NF-CO complex that acts to promote FT expression near dusk, whereas Polycomb group (PcG) proteins function to silence FT expression...
April 18, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29667237/the-trends-and-prevalence-of-obesity-and-morbid-obesity-among-australian-school-aged-children-1985-2014
#14
Joshua Xu, Louise L Hardy, Cici Z Guo, Sarah P Garnett
AIM: Children with obesity have a greater risk of adverse social and physical health outcomes. We examined temporal changes in body mass index (BMI) z-scores and the prevalence obesity and morbid obesity in children from 1985 to 2014. METHODS: Secondary data analysis of BMI data for children aged 7-15 years from five cross-sectional Australian datasets. Changes in age- and gender-adjusted BMI (BMI z-scores) and nutritional status were categorised using the International Obesity Task Force cut-off points...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667190/age-related-changes-in-late-i-waves-influence-motor-cortex-plasticity-induction-in-older-adults
#15
George M Opie, John Cirillo, John G Semmler
KEYPOINTS SUMMARY: The response to neuroplasticity interventions using transcranial magnetic stimulation (TMS) is reduced in older adults, which may be due, in part, to age-related alterations in interneuronal (I-wave) circuitry. The current study investigated age-related changes in interneuronal characteristics and whether they influence motor cortical plasticity in older adults. While I-wave recruitment was unaffected by age, there was a shift in the temporal characteristics of the late, but not early I-waves...
April 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29667037/use-of-seasonal-parameters-and-their-effects-on-fod-landfill-gas-modeling
#16
Nathan Bruce, Kelvin Tsun Wai Ng, Hoang Lan Vu
Temporal and spatial variations in landfill gas generations and emissions have been observed and reported by others. Real-time gas data between 2008 and 2014 from a municipal landfill located in a cold, semi-arid climate were consolidated to fit a linear-interpolated form of LandGEM. Seasonal variations in gas collection were observed in the landfill. LandGEM's default decay rate k was not applicable for this Canadian landfill due to significant overestimation (32.2% error). Optimal seasonal k and Lo collection parameters had 8...
April 18, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29666740/treatment-of-acute-psychosis-with-second-generation-antipsychotics-in-a-patient-with-left-temporal-lobe-lesion
#17
Richard Shehane, Steve Miller, Luke Suber, Miranda Chakos
We present a case of rapid onset severe psychosis followed by suicide attempt in a United States Navy sailor. Investigation revealed a left temporal lobe brain mass suspicious for low-grade glioma. After hospitalization and medical management with olanzapine and lurasidone the patient's psychosis improved. The purpose of this paper is to add to the existing case reports that suggest a relationship between temporal lobe lesions and psychiatric illness, specifically psychosis. In addition, this case adds insight into the effectiveness of medical therapy for brain tumor patients that are not immediate candidates for neurosurgical intervention...
2018: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29666739/prosopagnosia-as-a-type-of-conversion-disorder
#18
Clodagh Power, Oisin Hannigan, Robert Coen, Irene Bruce, Matthew Gibb, Marie McCarthy, David Robinson, Brian A Lawlor
Background: Conversion disorder is a common and debilitating condition that remains poorly understood. We present a previously undescribed form of conversion disorder to highlight the complexity of the condition and consider the interplay of factors that produce conversion symptoms. Case: A 50-year-old male presented with acquired prosopagnosia and language impairment. Neuropsychological testing indicated right temporal lobe dysfunction. Extensive work-up outruled an organic aetiology...
2018: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29666634/dynamical-motor-control-learned-with-deep-deterministic-policy-gradient
#19
Haibo Shi, Yaoru Sun, Jie Li
Conventional models of motor control exploit the spatial representation of the controlled system to generate control commands. Typically, the control command is gained with the feedback state of a specific instant in time, which behaves like an optimal regulator or spatial filter to the feedback state. Yet, recent neuroscience studies found that the motor network may constitute an autonomous dynamical system and the temporal patterns of the control command can be contained in the dynamics of the motor network, that is, the dynamical system hypothesis (DSH)...
2018: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/29666600/the-temporal-prediction-of-stress-in-speech-and-its-relation-to-musical-beat-perception
#20
REVIEW
Eleonora J Beier, Fernanda Ferreira
While rhythmic expectancies are thought to be at the base of beat perception in music, the extent to which stress patterns in speech are similarly represented and predicted during on-line language comprehension is debated. The temporal prediction of stress may be advantageous to speech processing, as stress patterns aid segmentation and mark new information in utterances. However, while linguistic stress patterns may be organized into hierarchical metrical structures similarly to musical meter, they do not typically present the same degree of periodicity...
2018: Frontiers in Psychology
keyword
keyword
41877
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"