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Alveolar recruitment

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https://www.readbyqxmd.com/read/27913191/the-shedding-derived-soluble-receptor-for-advanced-glycation-endproducts-sustains-inflammation-during-acute-pseudomonas-aeruginosa-lung-infection
#1
Antonella Antonelli, Stefania Di Maggio, Joanna Rejman, Francesca Sanvito, Alice Rossi, Alessandro Catucci, Andrea Gorzanelli, Alessandra Bragonzi, Marco E Bianchi, Angela Raucci
BACKGROUND: The membrane-bound isoform of the receptor for advanced glycation end products (FL-RAGE) is primarily expressed by alveolar epithelial cells and undergoes shedding by the protease ADAM10, giving rise to soluble cleaved RAGE (cRAGE). RAGE has been associated with the pathogenesis of several acute and chronic lung disorders. Whether the proteolysis of FL-RAGE is altered by a given inflammatory stimulus is unknown. Pseudomonas aeruginosa causes nosocomial infections in hospitalized patients and is the major pathogen associated with chronic lung diseases...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27896212/effect-of-slow-forced-eruption-on-the-vertical-levels-of-the-interproximal-bone-and-papilla-and-the-width-of-the-alveolar-ridge
#2
Eun-Young Kwon, Ju-Youn Lee, Jeomil Choi
OBJECTIVE: Forced eruption has been proposed for the reconstruction of deficient bone and soft tissue. The aim of this study was to examine the changes in the alveolar ridge width and the vertical levels of the interproximal bone and papilla following forced eruption. METHODS: Patients whose hopeless maxillary anterior teeth were expected to undergo severe bone resorption and soft tissue recession upon extraction were recruited. In addition, patients whose maxillary anterior teeth required forced eruption for restoration due to tooth fracture or dental caries were included...
November 2016: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/27885671/recruited-monocytic-myeloid-derived-suppressor-cells-promote-the-arrest-of-tumor-cells-in-the-premetastatic-niche-through-an-il-1%C3%AE-mediated-increase-in-e-selectin-expression
#3
Huifang Shi, Juechao Zhang, Xiaoqing Han, Huihan Li, Mingshu Xie, Yingying Sun, Wenguang Liu, Xueqing Ba, Xianlu Zeng
The tumor premetastatic niche initiated by primary tumors is constructed by multiple molecular factors and cellular components and provides permissive condition that allows circulating tumor cells to successfully metastasize. Myeloid-derived suppressor cells (MDSCs), a population of immature cells in pathological conditions, play a critical role in the formation of the premetastatic niche. However, few researches are focused on the function of monocytic MDSCs (mo-MDSCs), a subtype of MDSCs, in the construction of the niche...
November 25, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27831560/manipulating-the-air-filled-zebrafish-swim-bladder-as-a-neutrophilic-inflammation-model-for-acute-lung-injury
#4
Yuefei Zhang, Hongcui Liu, Junlin Yao, Yanfeng Huang, Shenlu Qin, Zheng Sun, Yingchun Xu, Shu Wan, Hongqiang Cheng, Chunqi Li, Xue Zhang, Yuehai Ke
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening diseases that are associated with high mortality rates due to treatment limitations. Neutrophils play key roles in the pathogenesis of ALI/ARDS by promoting the inflammation and injury of the alveolar microenvironment. To date, in vivo functional approaches have been limited by the inaccessibility to the alveolar sacs, which are located at the anatomical terminal of the respiratory duct in mammals...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27815367/nasal-high-flow-therapy-reduces-work-of-breathing-compared-to-oxygen-during-sleep-in-copd-and-smoking-controls-prospective-observational-study
#5
Paolo Jose Cesare Biselli, Jason P Kirkness, Ludger Grote, Kathrin Fricke, Alan R Schwartz, Philip Lees Smith, Hartmut Schneider
RATIONALE: Patients with COPD endure excessive resistive and elastic loads leading to chronic respiratory failure. Oxygen supplementation corrects hypoxemia but is not expected to reduce mechanical loads. Nasal High Flow therapy (NHF) supports breathing by reducing dead space but it is unclear how it affects mechanical loads of patients with COPD. OBJECTIVE: To compare the effects of low-flow oxygen and NHF on ventilation and work of breathing (WOB) in patients with COPD and controls during sleep...
November 4, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27805443/use-of-manual-alveolar-recruitment-maneuvers-to-eliminate-atelectasis-artifacts-identified-during-thoracic-computed-tomography-of-healthy-neonatal-foals
#6
Kara M Lascola, Stuart C Clark-Price, Stephen K Joslyn, Mark A Mitchell, Robert T O'Brien, Susan K Hartman, Kevin H Kline
OBJECTIVE To evaluate use of single manual alveolar recruitment maneuvers (ARMs) to eliminate atelectasis during CT of anesthetized foals. ANIMALS 6 neonatal Standardbred foals. PROCEDURES Thoracic CT was performed on spontaneously breathing anesthetized foals positioned in sternal (n = 3) or dorsal (3) recumbency when foals were 24 to 36 hours old (time 1), 4 days old (time 2), 7 days old (time 3), and 10 days old (time 4). The CT images were collected without ARMs (all times) and during ARMs with an internal airway pressure of 10, 20, and 30 cm H2O (times 2 and 3)...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27804117/effects-of-an-alveolar-recruitment-manoeuvre-guided-by-lung-ultrasound-on-anaesthesia-induced-atelectasis-in-infants-a-randomised-controlled-trial
#7
I-K Song, E-H Kim, J-H Lee, S Ro, H-S Kim, J-T Kim
Atelectasis occurs in the majority of children undergoing general anaesthesia. Lung ultrasound has shown reliable sensitivity and specificity for diagnosing anaesthesia-induced atelectasis. We assessed the effects of a recruitment manoeuvre on atelectasis using lung ultrasound in infants undergoing general anaesthesia. Forty infants, randomly allocated to either a recruitment manoeuvre group or a control group, received volume-controlled ventilation with 5 cmH2 O positive end-expiratory pressure. Lung ultrasound examination was performed twice in each patient, the first a minute after starting mechanical ventilation of the lungs and the second at the end of surgery...
November 2, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27798704/the-influenza-virus-protein-pb1-f2-increases-viral-pathogenesis-through-neutrophil-recruitment-and-nk-cells-inhibition
#8
Aurore Vidy, Pauline Maisonnasse, Bruno Da Costa, Bernard Delmas, Christophe Chevalier, Ronan Le Goffic
The influenza A virus (IAV) PB1-F2 protein is a virulence factor contributing to the pathogenesis observed during IAV infections in mammals. In this study, using a mouse model, we compared the host response associated with PB1-F2 with an early transcriptomic signature that was previously associated with neutrophils and consecutively fatal IAV infections. This allowed us to show that PB1-F2 is partly involved in neutrophil-related mechanisms leading to death. Using neutropenic mice, we confirmed that the harmful effect of PB1-F2 is due to an excessive inflammation mediated by an increased neutrophil mobilization...
2016: PloS One
https://www.readbyqxmd.com/read/27797602/bleomycin-increases-neutrophil-adhesion-to-human-vascular-endothelial-cells-independently-of-upregulation-of-icam-1-and-e-selectin
#9
James D Williamson, Laura R Sadofsky, Michael G Crooks, John Greenman, Simon P Hart
AIM OF THE STUDY: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis. The mechanisms underlying bleomycin-induced pulmonary fibrosis may be relevant to other progressive scarring diseases of the lungs. Pulmonary vascular endothelial cells are critically involved in immune cell extravasation at sites of injury through adhesion molecule expression and cytokine release...
October 31, 2016: Experimental Lung Research
https://www.readbyqxmd.com/read/27795356/mk2-signaling-shapes-macrophage-plasticity-in-aggregatibacter-actinomycetemcomitans-induced-bone-loss
#10
Bethany A Herbert, Heidi M Steinkamp, Matthias Gaestel, Keith L Kirkwood
Aggregatibacter actinomycetemcomitans is associated with aggressive periodontal disease, which is characterized by inflammation-driven alveolar bone loss. A. actinomycetemcomitans activates the p38 mitogen activated protein kinase (MAPK) and MAPK-activated protein kinase-2 (MK2) stress pathways in macrophages that are involved in host responses. During the inflammatory process in periodontal disease, chemokines are upregulated to promote recruitment of inflammatory cells. The objective of this study was to determine the role of MK2 signaling in chemokine regulation during A...
October 17, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27777976/epithelial-macrophage-interactions-determine-pulmonary-fibrosis-susceptibility-in-hermansky-pudlak-syndrome
#11
Lisa R Young, Peter M Gulleman, Chelsi W Short, Harikrishna Tanjore, Taylor Sherrill, Aidong Qi, Andrew P McBride, Rinat Zaynagetdinov, John T Benjamin, William E Lawson, Sergey V Novitskiy, Timothy S Blackwell
Alveolar epithelial cell (AEC) dysfunction underlies the pathogenesis of pulmonary fibrosis in Hermansky-Pudlak syndrome (HPS) and other genetic syndromes associated with interstitial lung disease; however, mechanisms linking AEC dysfunction and fibrotic remodeling are incompletely understood. Since increased macrophage recruitment precedes pulmonary fibrosis in HPS, we investigated whether crosstalk between AECs and macrophages determines fibrotic susceptibility. We found that AECs from HPS mice produce excessive MCP-1, which was associated with increased macrophages in the lungs of unchallenged HPS mice...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27757770/protective-effect-of-sesquiterpene-lactone-parthenolide-on-lps-induced-acute-lung-injury
#12
You Jin Jang, Moon Jung Back, Zhicheng Fu, Joo Hyun Lee, Jong Hoon Won, Hae Chan Ha, Hae Kyung Lee, Ji Min Jang, Jong Min Choi, Dae Kyong Kim
Acute lung injury (ALI) is a respiratory failure disease and the major source of mortality in the critically ill patients. The main pathological changes involved in ALI include the excessive recruitment and activation of neutrophils by increased pro-inflammatory mediators. However, any specific therapy for ALI has not been developed. The objective of this study was to investigate protective effects of parthenolide, a sesquiterpene lactone produced in feverfew, on LPS-induced lung injury. In the present study, parthenolide treatment reduced infiltration of inflammatory cells, airway permeability and production of pro-inflammatory cytokines in LPS-induced ALI mouse model...
October 18, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27746007/are-systemic-antibiotics-necessary-in-the-prevention-of-wound-healing-complications-after-intra-alveolar-dental-extraction
#13
O M Gbotolorun, I M Dipo-Fagbemi, A O Olojede, S Ebigwei, J O Adetoye
This double-blind, randomized controlled study was done to assess the necessity of systemic antibiotics in the prevention of wound healing complications after intra-alveolar dental extraction. A consecutive recruitment method was used to allocate participants to two treatment groups. Subjects in group A (antibiotics group, n=75) received amoxicillin and metronidazole for 5 days postoperatively, while those in group B (placebo group, n=75) were given identical-looking placebo drugs in place of the antibiotics...
October 13, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27739519/s-aureus-blocks-efferocytosis-of-neutrophils-by-macrophages-through-the-activity-of-its-virulence-factor-alpha-toxin
#14
Taylor S Cohen, Omari Jones-Nelson, Meghan Hotz, Lily Cheng, Lloyd S Miller, JoAnn Suzich, C Kendall Stover, Bret R Sellman
Bacterial pneumonia, such as those caused by Staphylococcus aureus, is associated with an influx of inflammatory neutrophils into the lung tissue and airways. Regulation and clearance of recruited neutrophils is essential for preventing tissue damage by "friendly fire", a responsibility of macrophages in a process called efferocytosis. We hypothesized that S. aureus impairs efferocytosis by alveolar macrophages (AMs) through the activity of the secreted virulence factor alpha toxin (AT), which has been implicated in altering the antimicrobial function of AMs...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27731391/epithelial-cell-derived-microvesicles-activate-macrophages-and-promote-inflammation-via-microvesicle-containing-micrornas
#15
Heedoo Lee, Duo Zhang, Ziwen Zhu, Charles S Dela Cruz, Yang Jin
Intercellular communications between lung epithelial cells and alveolar macrophages play an essential role in host defense against acute lung injury. Hyperoxia-induced oxidative stress is an established model to mimic human lung injury. We show that after hyperoxia-associated oxidative stress, a large amount of extracellular vesicles (EVs) are detectable in bronchoalveolar lavage fluid (BALF) and culture medium of lung epithelial cells. Microvesicles (MVs), but not exosomes (Exos) or apoptotic bodies (Abs), are the main type of EVs found in the early stages after hyperoxia...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27725237/a-standardized-bark-extract-of-pinus-pinaster-aiton-pycnogenol%C3%A2-attenuated-chronic-obstructive-pulmonary-disease-via-erk-sp1-signaling-pathway
#16
Na-Rae Shin, Hyung-Won Ryu, Je-Won Ko, Ji-Won Park, Ok-Kyoung Kwon, Sei-Ryang Oh, Jong-Choon Kim, In-Sik Shin, Kyung-Seop Ahn
ETHNOPHARMACOLOGICAL RELEVANCE: A standardized bark extract of Pinus pinaster Aiton (Pycnogenol(®); PYC) used as an herbal medicine to treat various diseases in Europe and North America. AIM OF THE STUDY: This study evaluates the ability of PYC to inhibit chronic obstructive pulmonary disease (COPD) in the cigarette smoke extract (CSE)-stimulated human airway epithelial cell line NCI-H292 and in a cigarette smoke (CS) and lipopolysaccharide (LPS)-induced mouse model...
October 7, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27711188/immunological-signatures-after-bordetella-pertussis-infection-demonstrate-importance-of-pulmonary-innate-immune-cells
#17
René H M Raeven, Jolanda Brummelman, Larissa van der Maas, Wichard Tilstra, Jeroen L A Pennings, Wanda G H Han, Cécile A C M van Els, Elly van Riet, Gideon F A Kersten, Bernard Metz
Effective immunity against Bordetella pertussis is currently under discussion following the stacking evidence of pertussis resurgence in the vaccinated population. Natural immunity is more effective than vaccine-induced immunity indicating that knowledge on infection-induced responses may contribute to improve vaccination strategies. We applied a systems biology approach comprising microarray, flow cytometry and multiplex immunoassays to unravel the molecular and cellular signatures in unprotected mice and protected mice with infection-induced immunity, around a B...
2016: PloS One
https://www.readbyqxmd.com/read/27698207/high-flow-nasal-cannula-therapy-for-adult-patients
#18
Jian Zhang, Ling Lin, Konghan Pan, Jiancang Zhou, Xiaoyin Huang
High-flow nasal cannula (HFNC) oxygen therapy has several physiological advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure in the pharynx, increasing alveolar recruitment in the lungs, humidification of the airways, increased fraction of inspired oxygen and improved mucociliary clearance. Recently, the use of HFNC in treating adult critical illness patients has significantly increased, and it is now being used in many patients with a range of different disease conditions...
October 2, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27694932/hyaluronan-and-tlr4-promote-surfactant-protein-c-positive-alveolar-progenitor-cell-renewal-and-prevent-severe-pulmonary-fibrosis-in-mice
#19
Jiurong Liang, Yanli Zhang, Ting Xie, Ningshan Liu, Huaiyong Chen, Yan Geng, Adrianne Kurkciyan, Jessica Monterrosa Mena, Barry R Stripp, Dianhua Jiang, Paul W Noble
Successful recovery from lung injury requires the repair and regeneration of alveolar epithelial cells to restore the integrity of gas-exchanging regions within the lung and preserve organ function. Improper regeneration of the alveolar epithelium is often associated with severe pulmonary fibrosis, the latter of which involves the recruitment and activation of fibroblasts, as well as matrix accumulation. Type 2 alveolar epithelial cells (AEC2s) are stem cells in the adult lung that contribute to the lung repair process...
October 3, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27694471/il-17a-mediated-expression-of-epithelial-il-17c-promotes-inflammation-during-acute-pseudomonas-aeruginosa-pneumonia
#20
Lisa Wolf, Sandra Sapich, Anja Honecker, Christopher Jungnickel, Frederik Seiler, Markus Bischoff, Bodo Wonnenberg, Christian Herr, Nicole Schneider-Daum, Claus-Michael Lehr, Robert Bals, Christoph Beisswenger
Lung epithelial cells are suggested to promote pathogen-induced pulmonary inflammation by the release of chemokines, resulting in enhanced recruitment of circulating leukocytes. Recent studies have shown that the interleukin-17C (IL-17C) regulates innate immune functions of epithelial cells in an autocrine manner. The aim of this study was to investigate the contribution of IL-17C to pulmonary inflammation in a mouse model of acute Pseudomonas aeruginosa pneumonia. Infection with P. aeruginosa resulted in an increased expression of IL-17C in lung tissue of wildtype mice...
September 30, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
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