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Alveolar recruitment

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https://www.readbyqxmd.com/read/28644107/gingival-perfusion-and-tissue-biomarkers-during-early-healing-of-post-extraction-regenerative-procedures-a-prospective-case-series
#1
Lamees Alssum, Timothy D Eubank, Sashwati Roy, Barbaros S Erdal, Vedat O Yildiz, Dimitris N Tatakis, Binnaz Leblebicioglu
BACKGROUND: Post-extraction alveolar bone loss, mostly affecting the buccal plate, occurs despite regenerative procedures. To better understand possible determinants, this prospective case series assessed gingival blood perfusion and tissue molecular responses in relation to post-extraction regenerative outcomes. METHODS: Adults scheduled to receive bone grafting in maxillary, non-molar, single tooth extraction site were recruited. Clinical documentation included probing pocket depth (PD), keratinized tissue width (KT), tissue biotype (TB), plaque (P) and bleeding...
June 23, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28622363/acyloxyacyl-hydrolase-promotes-the-resolution-of-lipopolysaccharide-induced-acute-lung-injury
#2
Benkun Zou, Wei Jiang, Han Han, Jing Li, Weiying Mao, Zihui Tang, Qian Yang, Guojun Qian, Jing Qian, Wenjiao Zeng, Jie Gu, Tianqing Chu, Ning Zhu, Wenhong Zhang, Dapeng Yan, Rui He, Yiwei Chu, Mingfang Lu
Pulmonary infection is the most common risk factor for acute lung injury (ALI). Innate immune responses induced by Microbe-Associated Molecular Pattern (MAMP) molecules are essential for lung defense but can lead to tissue injury. Little is known about how MAMP molecules are degraded in the lung or how MAMP degradation/inactivation helps prevent or ameliorate the harmful inflammation that produces ALI. Acyloxyacyl hydrolase (AOAH) is a host lipase that inactivates Gram-negative bacterial endotoxin (lipopolysaccharide, or LPS)...
June 16, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28620381/fxyd5-is-an-essential-mediator-of-the-inflammatory-response-during-lung-injury
#3
Patricia L Brazee, Pritin N Soni, Elmira Tokhtaeva, Natalia Magnani, Alex Yemelyanov, Harris R Perlman, Karen M Ridge, Jacob I Sznajder, Olga Vagin, Laura A Dada
The alveolar epithelium secretes cytokines and chemokines that recruit immune cells to the lungs, which is essential for fighting infections but in excess can promote lung injury. Overexpression of FXYD5, a tissue-specific regulator of the Na,K-ATPase, in mice, impairs the alveolo-epithelial barrier, and FXYD5 overexpression in renal cells increases C-C chemokine ligand-2 (CCL2) secretion in response to lipopolysaccharide (LPS). The aim of this study was to determine whether FXYD5 contributes to the lung inflammation and injury...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28604996/one-lung-ventilation-for-thoracic-surgery-current-perspectives
#4
Filippo Bernasconi, Federico Piccioni
One-lung ventilation (OLV) is an anesthesiological technique that is increasingly being used beyond thoracic surgery. This requires specific skills and knowledge about airway management, maintenance of gas exchange and prevention of acute lung injury. Sometimes maintaining adequate gas exchange and minimizing acute lung injury may be opposing processes. Parameters validated for OLV titration still have not been found, but a multimodal approach based on low tidal volume, end-expiratory pressure application and alveolar recruitment maneuvers is considered the best way to ensure protective ventilation and reduce lung damage...
June 7, 2017: Tumori
https://www.readbyqxmd.com/read/28601872/il-37-causes-excessive-inflammation-and-tissue-damage-in-murine-pneumococcal-pneumonia
#5
Anja E Schauer, Tilman E Klassert, Carolin von Lachner, Diana Riebold, Anne Schneeweiß, Magdalena Stock, Mario M Müller, Sven Hammerschmidt, Philip Bufler, Ulrike Seifert, Kristina Dietert, Charles A Dinarello, Marcel F Nold, Achim D Gruber, Claudia A Nold-Petry, Hortense Slevogt
Streptococcus pneumoniae infections can lead to severe complications with excessive immune activation and tissue damage. Interleukin-37 (IL-37) has gained importance as a suppressor of innate and acquired immunity, and its effects have been therapeutic as they prevent tissue damage in autoimmune and inflammatory diseases. By using RAW macrophages, stably transfected with human IL-37, we showed a 70% decrease in the cytokine levels of IL-6, TNF-α, and IL-1β, and a 2.2-fold reduction of the intracellular killing capacity of internalized pneumococci in response to pneumococcal infection...
June 10, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28596294/the-metalloproteinase-adam8-promotes-leukocyte-recruitment-in-vitro-and-in-acute-lung-inflammation
#6
Daniela Dreymueller, Jessica Pruessmeyer, Julian Schumacher, Sandra Fellendorf, Franz Martin Hess, Anke Seifert, Aaron Babendreyer, Joerg Walter Bartsch, Andreas Ludwig
Alveolar leukocyte recruitment is a hallmark of acute lung inflammation and involves transmigration of leukocytes through endothelial and epithelial layers. The disintegrin and metalloproteinase (ADAM) 8 is expressed on human isolated leukocytic cells and can be further upregulated on cultured endothelial and epithelial cells by proinflammatory cytokines. By shRNA mediated knockdown we show that leukocytic ADAM8 is required on monocytic THP-1 cells for chemokine-induced chemotaxis as well as transendothelial and transepithelial migration...
June 8, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28570003/age-of-onset-of-disease-in-subjects-with-severe-periodontitis-a-9-to-34-year-retrospective-study
#7
Sara Thorbert-Mros, Björn Cassel, Tord Berglundh
AIM: The aim was to retrospectively assess the age of onset of disease in a group of patients, 30-45 years of age, diagnosed with severe, generalized periodontitis. MATERIAL & METHODS: 74 patients agreed to be part of the study. Patient files and radiographs of 42 patients were retrieved from >80 private and public dental clinics. Interproximal sites in radiographs presenting with identifiable cement-enamel junction (CEJ) and alveolar bone crest (BC) were analyzed...
June 1, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28535788/endexpiratory-lung-volume-measurement-correlates-with-the-ventilation-perfusion-mismatch-in-lung-injured-pigs
#8
Jens Kamuf, Andreas Garcia-Bardon, Bastian Duenges, Tanghua Liu, Antje Jahn-Eimermacher, Florian Heid, Matthias David, Erik K Hartmann
BACKGROUND: In acute respiratory respiratory distress syndrome (ARDS) a sustained mismatch of alveolar ventilation and perfusion (VA/Q) impairs the pulmonary gas exchange. Measurement of endexpiratory lung volume (EELV) by multiple breath-nitrogen washout/washin is a non-invasive, bedside technology to assess pulmonary function in mechanically ventilated patients. The present study examines the association between EELV changes and VA/Q distribution and the possibility to predict VA/Q normalization by means of EELV in a porcine model...
May 23, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28535594/industrial-pm2-5-cause-pulmonary-adverse-effect-through-rhoa-rock-pathway
#9
Junyan Yan, Chia-Hsiang Lai, Shih-Chun Candice Lung, Chongjun Chen, Wen-Cheng Wang, Pin-I Huang, Chia-Hua Lin
According to the Chinese Ministry of Health, industrial pollution-induced health impacts have been the leading cause of death in China. While industrial fine particulate matter (PM2.5) is associated with adverse health effects, the major action mechanisms of different compositions of PM2.5 are currently unclear. In this study, we treated normal human lung epithelial BEAS-2B cells with industrial organic and water-soluble PM2.5 extracts under daily alveolar deposition dose to elucidate the molecular mechanisms underlying adverse pulmonary effects induced by PM2...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28528307/extracellular-atp-is-a-key-modulator-of-alveolar-bone-loss-in-periodontitis
#10
REVIEW
Itzhak Binderman, Nasir Gadban, Avinoam Yaffe
Periodontal diseases are initiated by pathogenic bacterial biofilm activity that induces a host inflammatory cells immune response, degradation of dento gingival fibrous tissue and its detachment from root cementum. It is well accepted, that osteoclastic alveolar bone loss is governed exclusively through secretion of proinflammatory cytokines. Nevertheless, our findings suggest that once degradation of collagen fibers by MMPs occurs, a drop of cellular strains cause immediate release of ATP from marginal gingival fibroblasts, cell deformation and influx of Ca+2...
May 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28522566/nedd8-modification-of-cullin-5-regulates-lipopolysaccharide-induced-acute-lung-injury
#11
Ziyan Zhu, Lei Sun, Rui Hao, Hongchao Jiang, Feng Qian, Richard D Ye
Lung infections are major causes of acute lung injury (ALI), with limited effective treatment available. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an essential adaptor regulating Toll-like receptors (TLRs). We recently identified Cullin-5 (Cul-5) as a prominent component in the regulation of TRAF6 polyubiquitination, but its physiological significance in acute lung injury has not been explored. In this study, we investigated the potential role of Cul-5 in regulating ALI using mice receiving intratracheal instillation of LPS...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28509332/myeloid-but-not-epithelial-tissue-factor-exerts-protective-anti-inflammatory-properties-in-acid-aspiration-induced-acute-lung-injury
#12
J B Kral-Pointner, W C Schrottmaier, V Horvath, H Datler, L Hell, C Ay, B Niederreiter, B Jilma, J A Schmid, A Assinger, N Mackman, S Knapp, G Schabbauer
INTRODUCTION: Acute lung injury (ALI) is a life-threatening condition characterized by damaged alveolar-capillary structures and activation of inflammatory and hemostatic processes. Tissue factor (TF) represents a crucial link between inflammation and coagulation, as inflammatory mediators induce myeloid TF expression and TF initiates the extrinsic coagulation. OBJECTIVE: Since pulmonary inflammation stimulates TF expression and TF modulates immune responses, we aimed to elucidate its impact on ALI...
May 16, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28507954/with-friends-like-these-the-complex-role-of-neutrophils-in-the-progression-of-severe-pneumonia
#13
REVIEW
Roger D Pechous
Pneumonia is a leading cause of death from infection in the United States and across the globe. During pulmonary infection, clear resolution of host inflammatory responses occurs in the absence of appreciable lung damage. Neutrophils are the first wave of leukocytes to arrive in the lung upon infection. After activation, neutrophils traffic from the vasculature via transendothelial migration through the lung interstitium and into the alveolar space. Successful pulmonary immunity requires neutrophil-mediated killing of invading pathogens by phagocytosis and release of a myriad of antimicrobial molecules, followed by resolution of inflammation, neutrophil apoptosis, and clearing of dead or dying neutrophils by macrophages...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28506464/recruited-monocytes-and-type-2-immunity-promote-lung-regeneration-following-pneumonectomy
#14
Andrew J Lechner, Ian H Driver, Jinwoo Lee, Carmen M Conroy, Abigail Nagle, Richard M Locksley, Jason R Rock
To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single-cell RNA sequencing found CD115+ and CCR2+ monocytes and M2-like macrophages accumulating in the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation. Genetic loss of function in mice and adoptive transfer studies revealed that bone marrow-derived macrophages (BMDMs) traffic to the lung through a CCL2-CCR2 chemokine axis and are required for optimal lung regeneration, along with Il4ra-expressing leukocytes...
May 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28500078/a-time-and-compartment-specific-activation-of-lung-macrophages-in-hypoxic-pulmonary-hypertension
#15
Steven C Pugliese, Sushil Kumar, William J Janssen, Brian B Graham, Maria G Frid, Suzette R Riddle, Karim C El Kasmi, Kurt R Stenmark
Studies in various animal models suggest an important role for pulmonary macrophages in the pathogenesis of pulmonary hypertension (PH). Yet, the molecular mechanisms characterizing the functional macrophage phenotype relative to time and pulmonary localization and compartmentalization remain largely unknown. In this study, we used a hypoxic murine model of PH in combination with FACS to quantify and isolate lung macrophages from two compartments over time and characterize their programing via RNA sequencing approaches...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28500076/stat5-is-required-for-cd103-dendritic-cell-and-alveolar-macrophage-development-and-protection-from-lung-injury
#16
William E Eddy, Ke-Qin Gong, Bryan Bell, William C Parks, Steven F Ziegler, Anne M Manicone
We tested the role of Stat5 in dendritic cell and alveolar macrophage (AM) homeostasis in the lung using CD11c-cre mediated deletion (Cre(+)5(f/f)). We show that Stat5 is required for CD103(+) dendritic cell and AM development. We found that fetal monocyte maturation into AMs was impaired in Cre(+)5(f/f) mice, and we also confirmed impaired AM development of progenitor cells using mixed chimera experiments. In the absence of Stat5 signaling in AMs, mice developed alveolar proteinosis with altered lipid homeostasis...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28494757/copd-monocytes-demonstrate-impaired-migratory-ability
#17
Arjun K Ravi, Jonathan Plumb, Rosemary Gaskell, Sarah Mason, Caroline S Broome, George Booth, Matthew Catley, Jørgen Vestbo, Dave Singh
BACKGROUND: Increased lung macrophage numbers in COPD may arise from upregulation of blood monocyte recruitment into the lungs. CCR5 is a monocyte chemokine receptor regulated by interleukin-6 (IL-6); the concentration of CCR5 ligands are known to be elevated in COPD lungs. The objective of this study was to investigate mechanisms of monocyte recruitment to the lung in COPD, including the role of CCR5 signalling. METHODS: Ninety one COPD patients, 29 smokers (S) and 37 non-smokers (NS) underwent sputum induction, plasma sampling (to measure IL-6 and soluble IL-6 receptor [sIL-6R] by immunoassay), monocyte characterization (by flow cytometry) and monocyte isolation for cell migration and quantitative polymerase chain reaction studies...
May 11, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28493530/m2-macrophages-induce-emt-through-the-tgf-%C3%AE-smad2-signaling-pathway
#18
Liangying Zhu, Xiao Fu, Xiang Chen, Xiaodong Han, Ping Dong
IPF is characterized by fibroblast accumulation, collagen deposition and ECM remodeling, with myofibroblasts believed to be the effector cell type. Myofibroblasts develop due to EMT of lung alveolar epithelial cells, which can be induced by TGF-β. M2 macrophages, a macrophage subpopulation, secrete large amounts of TGF-β. To clarify the relationship between IPF, EMT, TGF-β and M2 macrophages, a bleomycin-induced pulmonary fibrosis mouse model was used. Seventeen days after mice were treated with bleomycin, the successful establishment of a pulmonary fibrosis model was confirmed by HE stain and Masson's trichrome stain...
May 11, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28473321/hyperpolarized-gas-diffusion-mri-of-biphasic-lung-inflation-in-short-and-long-term-emphysema-models
#19
Yi Xin, Maurizio Cereda, Stephen Kadlecek, Kiarash Emami, Hooman Hamedani, Ian Duncan, Jennia Rajaei, Liam Hughes, Natalie Meeder, Joseph Naji, Harrilla Profka, Brian J Bolognese, Joseph P Foley, Patricia L Podolin, Rahim R Rizi
During lung-inflation, airspace dimensions are affected non-linearly by both alveolar expansion and recruitment, potentially confounding the identification of emphysematous lung by hyperpolarized helium-3 diffusion magnetic resonance imaging (HP MRI). This study aimed to characterize lung inflation over a broad range of inflation volume and pressure values in two different models of emphysema, as well as in normal lungs. Elastase-treated rats (n=7) and healthy controls (n=7) were imaged with HP MRI. Gradual inflation was achieved by incremental changes to both inflation volume and airway pressure...
May 4, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28467984/neutrophil-extracellular-traps-stimulate-proinflammatory-responses-in-human-airway-epithelial-cells
#20
Florencia Sabbione, Irene A Keitelman, Leonardo Iula, Mariana Ferrero, Mirta N Giordano, Pablo Baldi, Martín Rumbo, Carolina Jancic, Analía S Trevani
Tissue injury leads to the release of uric acid (UA). At high local concentrations, UA can form monosodium urate crystals (MSU). MSU and UA stimulate neutrophils to release extracellular traps (NET). Here, we investigated whether these NET could be involved in the development of inflammation by stimulating cytokine release by airway epithelial cells. We found that NET significantly increased the secretion of CXCL8/IL-8 and IL-6 by alveolar and bronchial epithelial cells. These effects were not observed when NETosis was inhibited by Diphenyleneiodonium, elastase inhibitor, or Cl-amidine...
May 4, 2017: Journal of Innate Immunity
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