keyword
https://read.qxmd.com/read/38536992/ozone-therapy-improves-early-stages-of-osseointegration-in-ovariectomized-rats
#1
JOURNAL ARTICLE
William Phillip Pereira da Silva, João Matheus Fonseca E Santos, Mônica Caroline de Souza, Stéfany Barbosa, Anderson Maikon de Souza Santos, Edilson Ervolino, Ana Paula Farnezi Bassi, Cortino Sukotjo, Leonardo P Faverani
OBJECTIVE: the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats. METHODOLOGY: ovariectomy was performed on 30 Wistar rats, aged six months (Rattus novergicus), and, after 90 days, osseointegrated implants were installed in each tibial metaphysis. The study groups were divided into the animals that received intraperitoneal ozone at a concentration of 700 mcg/kg - OZ Group (n=15) - and a control group that received an intraperitoneal saline solution and, for this reason, was named the SAL group (n=15)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536715/workspace-and-dexterity-analysis-of-the-hybrid-mechanism-master-robot-in-sina-flex-robotic-telesurgery-system-an-in-vivo-experiment
#2
JOURNAL ARTICLE
Mehrnaz Aghanouri, Hamid Moradi, Hossein A Alibeik, Alireza Mirbagheri
Sinaflex robotic telesurgery system has been introduced recently to provide ergonomic postures for the surgeon along with dexterous workspace for robotic telesurgery. The robot is described, and the forward and inverse kinematics are derived and validated by an experiment. The robot and operational workspaces and their dexterity are investigated and compared using the data collected during a dog vasectomy robotic telesurgery by Sinaflex . According to the simulation results, the workspace of the end effector is as large as 914...
February 2024: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://read.qxmd.com/read/38535706/static-magnetic-field-enhances-the-bone-remodelling-capacity-of-human-demineralized-bone-matrix-in-a-rat-animal-model-of-cranial-bone-defects
#3
JOURNAL ARTICLE
SeyedJamal Hosseini, Houman Parsaei, MirJavad Moosavifar, Narjes Tavakoli, Reza Ahadi, Kaveh Roshanbinfar
The regeneration of bone defects that exceed 2 cm is a challenge for the human body, necessitating interventional therapies. Demineralized bone matrices (DBM) derived from biological tissues have been employed for bone regeneration and possess notable osteoinductive and osteoconductive characteristics. Nevertheless, their efficiency in regenerating critically sized injuries is limited, and therefore additional signaling cues are required. Thanks to the piezoelectric properties of the bone, external physical stimulation is shown to accelerate tissue healing...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38534757/to-repair-a-broken-heart-stem-cells-in-ischemic-heart-disease
#4
REVIEW
Theodora M Stougiannou, Konstantinos C Christodoulou, Ioannis Dimarakis, Dimitrios Mikroulis, Dimos Karangelis
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534489/comparative-analysis-of-bone-regeneration-according-to-particle-type-and-barrier-membrane-for-octacalcium-phosphate-grafted-into-rabbit-calvarial-defects
#5
JOURNAL ARTICLE
Se-Wook Pyo, Jeong-Won Paik, Da-Na Lee, Young-Wook Seo, Jin-Young Park, Sunjai Kim, Seong-Ho Choi
This animal study was aimed to evaluate the efficacy of new bone formation and volume maintenance according to the particle type and the collagen membrane function for grafted octacalcium phosphate (OCP) in rabbit calvarial defects. The synthetic bone substitutes were prepared in powder form with 90% OCP and granular form with 76% OCP, respectively. The calvarial defects were divided into four groups according to the particle type and the membrane application. All specimens were acquired 2 weeks (n = 5) and 8 weeks (n = 5) after surgery...
February 24, 2024: Bioengineering
https://read.qxmd.com/read/38534477/carotid-artery-bypass-surgery-of-in-body-tissue-architecture-induced-small-diameter-biotube-in-a-goat-model-a-pilot-study
#6
JOURNAL ARTICLE
Tadashi Umeno, Kazuki Mori, Ryosuke Iwai, Takayuki Kawashima, Takashi Shuto, Yumiko Nakashima, Tsutomu Tajikawa, Yasuhide Nakayama, Shinji Miyamoto
Biotubes are autologous tubular tissues developed within a patient's body through in-body tissue architecture, and they demonstrate high potential for early clinical application as a vascular replacement. In this pilot study, we used large animals to perform implantation experiments in preparation for preclinical testing of Biotube. The biological response after Biotube implantation was histologically evaluated. The designed Biotubes (length: 50 cm, internal diameter: 4 mm, and wall thickness: 0.85 mm) were obtained by embedding molds on the backs of six goats for a predetermined period (1-5 months)...
February 21, 2024: Bioengineering
https://read.qxmd.com/read/38534373/approaching-thrombospondin-1-as-a-potential-target-for-mesenchymal-stromal-cells-to-support-liver-regeneration-after-partial-hepatectomy-in-mouse-and-humans
#7
JOURNAL ARTICLE
Lysann Tietze, Madlen Christ, Jiyeon Yu, Peggy Stock, Sandra Nickel, Annelie Schulze, Michael Bartels, Hans-Michael Tautenhahn, Bruno Christ
Extended liver resection carries the risk of post-surgery liver failure involving thrombospondin-1-mediated aggravation of hepatic epithelial plasticity and function. Mesenchymal stromal cells (MSCs), by interfering with thrombospondin-1 (THBS1), counteract hepatic dysfunction, though the mechanisms involved remain unknown. Herein, two-thirds partial hepatectomy in mice increased hepatic THBS1, downstream transforming growth factor-β3, and perturbation of liver tissue homeostasis. All these events were ameliorated by hepatic transfusion of human bone marrow-derived MSCs...
March 17, 2024: Cells
https://read.qxmd.com/read/38532826/neuropathology-and-epilepsy-surgery-2024-update
#8
JOURNAL ARTICLE
Ingmar Blümcke
Neuropathology-based studies in neurosurgically resected brain tissue obtained from carefully examined patients with focal epilepsies remain a treasure box for excellent insights into human neuroscience, including avenues to better understand the neurobiology of human brain organization and neuronal hyperexcitability at the cellular level including glio-neuronal interaction. It also allows to translate results from animal models in order to develop personalized treatment strategies in the near future. A nice example of this is the discovery of a new disease entity in 2017, termed mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy or MOGHE, in the frontal lobe of young children with intractable seizures...
January 2024: Free neuropathology
https://read.qxmd.com/read/38532332/effects-of-remote-ischemic-preconditioning-in-hepatectomy-a-systematic-review-and-meta-analysis
#9
Chun Tian, Aihua Wang, He Huang, Youwan Chen
BACKGROUND: Animal experiments have confirmed that remote ischemic preconditioning (RIPC) can reduce hepatic ischemia-reperfusion injuries (HIRIs), significantly improving early tissue perfusion and oxygenation of the residual liver after resections, accelerating surgical prognoses, and improving survival rates. However, there is still controversy over the role of RIPC in relieving HIRI in clinical studies, which warrants clarification. This study aimed to evaluate the beneficial effects and applicability of RIPC in hepatectomy and to provide evidence-based information for clinical decision-making...
March 26, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38532201/enhancing-fat-transplantation-efficiency-in-a-mouse-model-through-pretreatment-of-adipose-derived-stem-cells-with-rip3-inhibitors
#10
JOURNAL ARTICLE
Zhenyu Yang, Haibin Lu, Qiuni Gao, Xihang Yuan, Yuling Hu, Zuoliang Qi
BACKGROUND: Autologous fat transplantation, widely used in cosmetic and reparative surgery for volumetric enhancements, faces challenges with its inconsistent long-term survival rates. The technique's efficacy, crucial for its development, is hindered by unpredictable outcomes. Enriching fat grafts with adipose-derived stem cells (ADSCs) shows promise in improving survival efficiency. OBJECTIVES: This study aimed to explore the potential of receptor-interacting protein kinase 3 (RIP3) kinase inhibitors as a pretreatment for ADSCs in enhancing autologous fat graft retention over a long term...
March 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38532200/investigation-of-two-new-grafting-techniques-for-dorsal-augmentation-rhinoplasty-an-experimental-study-with-new-zealand-white-rabbits
#11
JOURNAL ARTICLE
Mehmet Ozdemır, Mehmet Fatih Akkoç, Selcuk Tunık
INTRODUCTION: Cartilage is an important source in supporting the structure of the nose for dorsal augmentation rhinoplasty. However, it is known that its viability is not always on the ideal level. Various wrapping materials are used to increase the strength of cartilage. Donor site morbidity, which develops following the harvesting of both cartilage and fascia as one such cover material, has attracted interest in recent years. OBJECTIVE: In this study, we aimed to investigate the potential of dermis and tendon autografts as alternatives to fascia and cartilage...
March 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38532182/a-pig-model-of-symptomatic-spinal-epidural-hematoma
#12
JOURNAL ARTICLE
Jiasheng Chen, Haozheng Li, Shengxin Zeng, Hua Zhou, Xiao Liu, Panpan Hu, Xiaoguang Liu, Zhongjun Liu, Feng Wei, Zihe Li
PURPOSE: The purpose of this study was to establish an animal model capable of simulating the development and decompression process of symptomatic spinal epidural hematoma (SSEH). METHODS: A total of 16 male Bama miniature pigs were included in this study and randomly allocated into four groups: Group A (4 h 20 mmHg hematoma compression), Group B (4 h 24 mmHg hematoma compression), Group C (4 h 28 mmHg hematoma compression), and Group Sham (control)...
March 27, 2024: European Spine Journal
https://read.qxmd.com/read/38531819/a-mechanistic-and-preclinical-assessment-of-biorestore-bioactive-glass-as-a-synthetic-bone-graft-extender-and-substitute-for-osteoinduction-and-spine-fusion
#13
JOURNAL ARTICLE
Elianna J Fred, Silvia Minardi, Alyssa M Goodwin, Tejas S Nandurkar, Mark A Plantz, Joseph G Lyons, Jonathan T Paul, James P Foley, Allison J Wintring, Andrew A Furman, Soyeon Jeong, Chawon Yun, Stuart R Stock, Wellington K Hsu, Erin L Hsu
STUDY DESIGN: Preclinical animal study. OBJECTIVE: Evaluate the osteoinductivity and bone regenerative capacity of BioRestore bioactive glass. SUMMARY OF BACKGROUND DATA: BioRestore is a Food and Drug Administration (FDA)-approved bone void filler that has not yet been evaluated as a bone graft extender or substitute for spine fusion. METHODS: In vitro and in vivo methods were used to compare BioRestore with other biomaterials for the capacity to promote osteodifferentiation and spinal fusion...
March 22, 2024: Clinical Spine Surgery
https://read.qxmd.com/read/38530321/androgenic-steroids-induce-pathologic-scarring-in-a-preclinical-porcine-model-via-dysfunctional-extracellular-matrix-deposition
#14
JOURNAL ARTICLE
Erik Reiche, Patrick R Keller, Vance Soares, Calvin R Schuster, Siti Rahmayanti, Jessica Mroueh, Vanessa Mroueh, Marie Billaud, Sophia Hu, Hunter Hoover-Watson, Christine G Lian, Yu Tan, Joshua C Doloff, Annie E Newell-Fugate, Devin Coon
Hypertrophic scarring is a major source of morbidity. Sex hormones are not classically considered modulators of scarring. However, based on increased frequency of hypertrophic scarring in patients on testosterone, we hypothesized that androgenic steroids induce abnormal scarring and developed a preclinical porcine model to explore these effects. Mini-swine underwent castration, received no testosterone (noT) or biweekly testosterone therapy (+T), and underwent excisional wounding. To create a delayed wound healing model, a subset of wounds were re-excised at 2 weeks...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38530304/independent-and-combined-effects-of-obesity-and-traumatic-joint-injury-to-the-structure-and-composition-of-rat-knee-cartilage
#15
JOURNAL ARTICLE
Kalle Karjalainen, Petri Tanska, Kelsey H Collins, Walter Herzog, Rami K Korhonen, Eng Kuan Moo
Osteoarthritis (OA) is a multifactorial joint disease characterized by articular cartilage degradation. Risk factors for OA include joint trauma, obesity, and inflammation, each of which can affect joint health independently, but their interaction and the associated consequences of such interaction were largely unexplored. Here, we studied compositional and structural alterations in knee joint cartilages of Sprague-Dawley rats exposed to two OA risk factors: joint injury and diet-induced obesity. Joint injury was imposed by surgical transection of anterior cruciate ligaments (ACLx), and obesity was induced by a high fat/high sucrose diet...
March 26, 2024: Connective Tissue Research
https://read.qxmd.com/read/38529297/the-effect-of-nonsteroidal-anti-inflammatory-drug-use-on-soft-tissue-and-bone-healing-in-the-knee-a-systematic-review
#16
REVIEW
Rafat H Solaiman, Jack Dirnberger, Nicholas I Kennedy, Nicholas N DePhillipo, Adam J Tagliero, Konrad Malinowski, Sigbjorn Dimmen, Robert F LaPrade
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to mitigate pain and inflammation associated with musculoskeletal conditions; however, there is conflicting data on the adverse effects of these drugs on tissue and bone healing. The objective of this study was to investigate the effect of NSAIDs on the healing of knee, soft tissue, and bone. METHODS: A systematic literature search was conducted across PubMed/MEDLINE, Excerpta Medical Database (Embase)/Ovid, and the Cochrane Central Register of Controlled Trials databases...
2024: Annals of joint
https://read.qxmd.com/read/38528611/effects-of-alendronate-on-cartilage-lesions-and-micro-architecture-deterioration-of-subchondral-bone-in-patellofemoral-osteoarthritic-ovariectomized-rats-with-patella-baja
#17
JOURNAL ARTICLE
Mingjian Bei, Zhiyuan Zheng, Yaping Xiao, Ning Liu, Xuehui Cao, Faming Tian, Liu Zhang, Xinbao Wu
BACKGROUND: Patellofemoral osteoarthritis (PFJOA) is a subtype of knee OA, which is one of the main causes of anterior knee pain. The current study found an increased prevalence of OA in postmenopausal women, called postmenopausal OA. Therefore, we designed the ovariectomized rat model of patella baja-induced PFJOA. Alendronate (ALN) inhibits osteoclast-mediated bone loss, and has been reported the favorable result of a potential intervention option of OA treatment. However, the potential effects of ALN treatment on PFJOA in the ovariectomized rat model are unknown and need further investigation prior to exploration in the clinical research setting...
March 25, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38528127/3d-bioprinting-based-dopamine-coupled-flexible-material-for-nasal-cartilage-repair
#18
JOURNAL ARTICLE
Wendan Jia, Zixian Liu, Zhuwei Ma, Peiyi Hou, Yanyan Cao, Zhizhong Shen, Meng Li, Hulin Zhang, Xing Guo, Shengbo Sang
INTRODUCTION: Since 3D printing can be used to design implants according to the specific conditions of patients, it has become an emerging technology in tissue engineering and regenerative medicine. How to improve the mechanical, elastic and adhesion properties of 3D-printed photocrosslinked hydrogels is the focus of cartilage tissue repair and reconstruction research. MATERIALS AND METHODS: We established a strategy for toughening hydrogels by mixing GelMA-DOPA (GD), which is prepared by coupling dopamine (DA) with GelMA, with HAMA, bacterial cellulose (BC) to produce composite hydrogels (HB-GD)...
March 25, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38528064/visualization-of-bone-formation-in-sheep-s-middle-ear-by-using-fluorochrome-sequential-labelling-fsl
#19
JOURNAL ARTICLE
Max Kemper, Anne Kluge, Michael Ney, Thomas Beleites, Ines Zeidler-Rentzsch, Christiane Keil, Thomas Zahnert, Marcus Neudert
One factor for the lacking integration of the middle ear stapes footplate prosthesis or the missing healing of stapes footplate fractures could be the known osteogenic inactivity. In contrast, it was recently demonstrated that titanium prostheses with an applied collagen matrix and immobilised growth factors stimulate osteoblastic activation and differentiation on the stapes footplate. Regarding those findings, the aim of this study was to evaluate the potential of bone regeneration including bone remodeling in the middle ear...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527988/magnetic-resonance-imaging-combined-with-histological-evaluation-of-repair-process-using-the-microfracture-technique-in-an-association-of-osteocartilaginous-and-meniscal-surgically-induced-lesions-of-the-knee-in-vivo-experiment-on-a-rabbit-model
#20
JOURNAL ARTICLE
Jenel Marian Pătraşcu, Sorin Florescu, Silviu Brad, Bogdan Corneliu Andor, Iosif Ilia, Ştefan Iulian Stănciugelu, Romeo Teodor Cristina
The present research study aimed to assess magnetic resonance imaging (MRI) changes and histological findings in the therapeutic effects of microfractures in the treatment of complex animal knee lesions resulting from osteochondral and meniscal defects resulting from non-total meniscectomies. The anterior cruciate ligament lesions are also proven to facilitate the development of osteoarthritis in the knee and worsen the prognosis. Surgery was performed on the right knee joint of 22 male rabbits in order to partially remove the anterior horn of the internal meniscus and to induce an osteochondral defect at the level of the internal femoral condyle...
2024: Romanian Journal of Morphology and Embryology
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