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female pelvic organ prolapse

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https://www.readbyqxmd.com/read/28783735/the-role-of-gpx1-in-the-pathogenesis-of-female-pelvic-organ-prolapse
#1
Shasha Hong, Li Hong, Bingshu Li, Debin Wu, Cheng Liu, Jie Min, Wenjun Guo, Ming Hu, Jianming Tang, Yang Li
Gestation and delivery can increase intra-abdominal pressure, which are well-known risk factors for Pelvic Organ Prolapse (POP). But the pathogenesis mechanism of POP remains unclear. Our previous research showed that the expression of glutathione peroxidase type 1 (GPX1) decreased in pelvic floor ligaments from POP patients, implying that oxidative stress (OS) may be related to POP. The aim of this study was to figure out the role of GPx1 regulation in the pathogenesis of POP. Women (>45 years) who received hysterectomy surgery were enrolled in this research, identified by screening...
2017: PloS One
https://www.readbyqxmd.com/read/28767163/predictors-of-sexual-function-in-women-with-stress-urinary-incontinence
#2
Magdalena E Grzybowska, Dariusz Wydra
AIMS: To assess female sexual function (SF) in different grades of urodynamic stress urinary incontinence (SUI), with/without pelvic organ prolapse (POP); to investigate associations between clinical data and pelvic organ prolapse/urinary incontinence sexual questionnaire (PISQ) scores. METHODS: A cross-sectional study was conducted in sexually active women (130 with SUI and 126 controls). Stamey score and POP quantification (POP-Q) were used. Urogynecological examinations were performed; all participants completed PISQ...
August 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28746921/effects-of-transobturator-midurethral-sling-surgery-on-sexual-functions-one-year-follow-up
#3
Ergul Aslan, Funda Gungor Ugurlucan, Dilek Bilgic, Onay Yalcin, Nezihe Kizilkaya Beji
AIM: To evaluate sexual functions of women having stress urinary incontinence (SUI) preoperatively and 6 months and 12 months after undergoing a transobturator tape (TOT) ± pelvic organ prolapse (POP) surgery. METHODS: One hundred-ninety-five women with SUI ± POP were recruited and 150 sexually active women who had clinical ± urodynamic SUI and underwent TOT ± POP surgery were included in this prospective study. Urogynecologic symptoms were evaluated preoperatively, at 6 months, and 12 months by Female Sexual Function Index (FSFI)...
July 27, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28733790/is-a-dragging-sensation-a-symptom-of-female-pelvic-organ-prolapse
#4
Hans Peter Dietz, Candice Chatel, Ixora Kamisan Atan
INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) commonly presents with a "vaginal lump or bulge" and/or a "dragging sensation." The first symptom correlates strongly with clinical and imaging data. However, a "dragging sensation" may be less specific. Hence, we investigated the predictive value of both symptoms for POP. METHODS: This was a retrospective study involving archived data sets of women seen between November 2013 and May 2014. All underwent a clinical interview, POPQ examination, and 4D translabial ultrasound (TLUS)...
July 21, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28709582/the-incidence-of-transfusion-and-associated-risk-factors-in%C3%A2-pelvic-reconstructive-surgery
#5
Lopa K Pandya, Courtney D Lynch, Andrew F Hundley, Silpa Nekkanti, Catherine O Hudson
BACKGROUND: Almost 400,000 female pelvic reconstructive operations were performed in 2010 for urinary incontinence and pelvic organ prolapse in the United States, and it is likely that this will continue to increase each year. There is a lack of population-based data evaluating the risk of blood transfusion after urogynecologic procedures. OBJECTIVE: We sought to assess the incidence of blood transfusion related to pelvic reconstructive surgery in a large national surgical quality database and to identify transfusion-associated risk factors...
July 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28705367/dynamic-magnetic-resonance-imaging-of-the-pelvic-floor
#6
Sindhura Alapati, Kedar Jambhekar
Pelvic floor dysfunction is a widespread condition affecting up to 50% of elderly women. It markedly compromises the quality of life owing to various disabling symptoms such as pelvic pain, pelvic organ prolapse, and urinary and fecal incontinence. Although age and female sex are the main risk factors, others include multiparity, obesity, and connective tissue disorders. Pelvic floor dysfunction is frequently multicompartmental, and failure to diagnose it accurately often leads to treatment failure. Dynamic pelvic floor magnetic resonance imaging is a robust tool that enables simultaneous visualization of the 3 pelvic floor compartments and is indispensable for precise preoperative evaluation...
June 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28696484/vaginal-changes-due-to-varying-degrees-of-rectocele-prolapse-a-computational-study
#7
Arnab Chanda, Isuzu Meyer, Holly E Richter, Mark E Lockhart, Fabia R D Moraes, Vinu U Unnikrishnan
Pelvic organ prolapse (POP), downward descent of the pelvic organs resulting in a protrusion of the vagina, is a highly prevalent condition, responsible for 300,000 surgeries in the United States annually. Rectocele, a posterior vaginal wall prolapse of the rectum is the second most common type of POP after cystocele. A rectocele usually manifests itself along with other types of prolapse with multi-compartment pelvic floor defects. To date, the specific mechanics of rectocele formation are poorly understood, which does not allow its early stage detection and progression prediction over time...
July 11, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28686982/efficacy-of-biofeedback-on-quality-of-life-in-stages-i-and-ii-pelvic-organ-prolapse-a-pilot-study
#8
Tannaz Ahadi, Neda Taghvadoost, Soheila Aminimoghaddam, Bijan Forogh, Roxana Bazazbehbahani, Gholam Reza Raissi
OBJECTIVES: Pelvic organ prolapse (POP) is a prevalent disorder which seriously affects the sufferer's quality of life. The main goal of this study was to evaluate biofeedback impact on quality of life in women with mild to moderate POP. STUDY DESIGN: 40 females in stages I and II POP were allocated into 2 groups. One group received pelvic floor muscle exercise and lifestyle advice in addition to biofeedback twice a week for 4 weeks, while the other received a lifestyle advice sheet and pelvic floor muscle exercise without biofeedback...
June 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28676367/iatrogenic-pelvic-pain-surgical-and-mesh-complications
#9
REVIEW
Dominic Lee, John Chang, Philippe E Zimmern
Female stress urinary incontinence and pelvic organ prolapse are prevalent conditions in adult women. Among treatment alternatives, more traditional methods of surgical intervention have been supplanted by synthetic polypropylene mesh kits. However, novel complications with mesh-related exposure, pelvic pain alone or with dyspareunia, and increased incidence of revision surgeries, resulted in 2 FDA warnings on transvaginal mesh use for prolapse repair. This review examines the anatomy of the vagina and urethra, the etiology of pain related to mesh use, and the relevant surgical techniques for management of this complication along with their outcomes...
August 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/28657986/the-truth-behind-transvaginal-mesh-litigation-devices-timelines-and-provider-characteristics
#10
Colby P Souders, Karyn S Eilber, Lynn McClelland, Lauren N Wood, Alexander R Souders, Vicki Steiner, Jennifer Tash Anger
OBJECTIVES: Following Food and Drug Administration communications about the safety of transvaginal prolapse, more than 73,000 patients with complications from treatment of pelvic organ prolapse (POP) or stress urinary incontinence (SUI) have filed product liability claims. This research analyzes the transvaginal mesh claims filed in the United States to identify key characteristics that may inform clinical decision-making. METHODS: We evaluated a 1% random sample from the Bloomberg Law Database: 2000 to 2014 and associated legal documents...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28643025/effects-of-bariatric-surgery-on-pelvic-floor-disorders-in-obese-women-a-meta-analysis
#11
REVIEW
Wenqing Lian, Yiqun Zheng, Hongxing Huang, Lianghua Chen, Bin Cao
PURPOSE: Obesity is an established risk factor for pelvic floor disorders (PFD) but the effects of bariatric surgery on PFD are uncertain. This meta-analysis was conducted to evaluate the effects of bariatric surgery on PFD in obese women. METHODS: A systematic search of PubMed, Cochrane Library, CNKI and CBM databases up to October 2016 was performed, and studies reporting pre-operative and post-operative outcomes in obese women undergoing bariatric surgery were included...
August 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28635410/pelvic-floor-dysfunction-and-polycystic-ovary-syndrome
#12
Seyed Abdolvahab Taghavi, Fatemeh Bazarganipour, Helen Allan, Zahra Khashavi, Nasrin Reisi, Nadiyeh Dosha, Fatemeh Aghili, Mohadeseh Keramati, Sedigheh Zahedi, Amireh Aji-Ramkani
The purpose of this study was to compare the prevalence of pelvic floor dysfunction (PFD) symptoms in patients with and without polycystic ovary syndrome (PCOS) and among different PCOS phenotypes. This was a case-control study. All participants were assessed using ultrasonography to determine the presence or absence of polycystic ovaries (PCO) and allocated to the case or control group (having healthy females whose husbands were diagnosed with male infertility). The case group was then further subdivided into the three phenotypes according to the presence or absence of menstrual dysfunction (M), hyperandrogenism (HA) and PCO on ultrasonography...
February 21, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28630221/retrorectal-tumour-simulating-vaginal-birth-an-exceptional-case-of-emergency-surgery-indication
#13
Eduardo Alvarez-Sarrado, Salvador Pous-Serrano, Omar Carreño Saenz, Jose Pamies-Gilabert
Cystic retrorectal tumours are a very rare entity that pose a problem in differential diagnosis between congenital cyst and other lesions. We present a 49-year-old female patient presenting a perineal bulge which was discovered simulating a vaginal birth associated with prolapsed haemorrhoids grade IV. The interest of this case resides in the surgical indication of a big presacral cyst demonstrated via CT causing acute intense pain due to pelvic organ compression, as no emergent surgery management has been reported up to date...
June 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28624916/interethnic-variation-in-pelvic-floor-morphology-in-women-with-symptomatic-pelvic-organ-prolapse
#14
Zeelha Abdool, Hans Peter Dietz, Barend Gerhardus Lindeque
INTRODUCTION AND HYPOTHESIS: There is a lack of epidemiological studies evaluating female pelvic organ prolapse in developing countries. Current studies have largely focused on women of white ethnicity. This study was designed to determine interethnic variation in pelvic floor functional anatomy, namely, levator hiatal distensibility and pelvic organ descent, in women with symptomatic pelvic organ prolapse in a multi-ethnic South African population. METHODS: This prospective observational study included 258 consecutive women referred for pelvic organ prolapse assessment and management at a tertiary urogynaecological clinic...
June 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28616104/medicolegal-basics-and-update-on-transvaginal-mesh-in-canada
#15
REVIEW
Brock Hengel, Blayne Welk, Richard J Baverstock
In recent years, midurethral slings (MUS) and transvaginal mesh procedures have experienced blazing growth and popularity. However, the US Food and Drug Administration (FDA) and Health Canada regulatory advisories threw water on that fire and created a confusing environment surrounding their continued usage. MUS usage has continued in Canada and transvaginal mesh kits for pelvic organ prolapse have become a rarity. Several large organizations (the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction [SUFU], the American Urogynecologic Society [AUGS], and the Canadian Urological Association [CUA]) have developed "mesh statements" to clarify the issues surrounding mesh for patients and medical professionals; however, often the legal system sees things differently in either individual cases or class action lawsuits...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28607242/factors-enabling-women-with-pelvic-organ-prolapse-to-seek-surgery-at-mobile-surgical-camps-in-two-remote-districts-in-nepal-a-qualitative-study
#16
Mala Chalise, Malinda Steenkamp, Binaya Chalise
BACKGROUND: Pelvic organ prolapse (POP) is a major reproductive health problem in Nepal, though many women delay seeking treatment. To address this, the Nepalese government has been providing free vaginal hysterectomies with pelvic floor repair to women in mobile surgical camps. Studies exploring factors that enable women to attend these camp settings are limited. This study aimed to identify factors that affected women seeking surgical treatment for POP at mobile surgical camps. METHODS: The study used a qualitative approach...
September 2016: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28602772/urine-leakage-during-sexual-activity-among-ethnically-diverse-community-dwelling-middle-aged-and-older%C3%A2-women
#17
Nagambika Munaganuru, Stephen K Van Den Eeden, Jennifer Creasman, Leslee L Subak, Lisa Strano-Paul, Alison J Huang
BACKGROUND: Urinary incontinence is associated with decreased female sexual function, but little is known about the prevalence, predictors, and impact of urine leakage during sexual activity among women in the community. OBJECTIVE: The purpose of this study was to evaluate the prevalence and impact of urine leakage during sex in ethnically diverse, community-dwelling midlife and older women. STUDY DESIGN: Urinary incontinence and sexual function were assessed by structured questionnaire in a multiethnic, community-based cohort of women enrolled in Kaiser Permanente Northern California, an integrated healthcare delivery system in California...
June 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28591209/sexual-function-and-postpartum-depression-6-months-after-attempted-operative-vaginal-delivery-according-to-fetal-head-station-a-prospective-population-based-cohort-study
#18
Guillaume Ducarme, Jean-François Hamel, Stéphanie Brun, Hugo Madar, Benjamin Merlot, Loïc Sentilhes
OBJECTIVE: To evaluate the effect of the fetal head station at attempted operative vaginal delivery (aOVD), and specifically midpelvic or low aOVD, on female and male sexual function and symptoms of postpartum depression (PPD) at 6 months. DESIGN: Prospective population-based cohort study. SETTING: 1,941 women with singleton term fetuses in vertex presentation with midpelvic or low aOVD between 2008 and 2013 in a tertiary care university hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28547268/primary-care-providers-experience-management-and-referral-patterns-regarding-pelvic-floor-disorders-a-national-survey
#19
Donna Mazloomdoost, Catrina C Crisp, Steven D Kleeman, Rachel N Pauls
INTRODUCTION AND HYPOTHESIS: Primary care physicians can impact womens' access to care. We assessed primary care providers' experience and management regarding pelvic floor disorders. METHODS: This Institutional Review Board approved study invited internal and family Medicine Program Directors to complete and distribute to faculty an online survey designed to query demographics, perceptions, management, and referral patterns regarding urinary incontinence (UI), overactive bladder (OAB), and pelvic organ prolapse (POP) in females...
May 25, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28546660/can-we-deliver-better
#20
REVIEW
Ajay Rane, Jay Iyer, Harsha Ananthram, Thomas Currie
Human childbirth has been described as an "obstetrical dilemma". Evolution favours enlargement of the foetal brain, whilst bipedal locomotion demands a reduction in pelvic breadth for improvements in biomechanical efficiency. The result of this conflict is a human pelvis incongruous with the dynamics of childbirth. Acute genital distortion at delivery can inflict lasting damage to female pelvic function. Pelvic organ prolapse, urinary, faecal incontinence and sexual dysfunction are long-term sequelae rarely discussed at antenatal care, impacting upon the expectant mother's ability to make an informed decision...
June 2017: Journal of Obstetrics and Gynaecology of India
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