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Quorum sensing inhibition, Pseudomonas aeruginosa

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https://www.readbyqxmd.com/read/28453568/baicalin-inhibits-biofilm-formation-attenuates-the-quorum-sensing-controlled-virulence-and-enhances-pseudomonas-aeruginosa-clearance-in-a-mouse-peritoneal-implant-infection-model
#1
Jing Luo, Biying Dong, Ke Wang, Shuangqi Cai, Tangjuan Liu, Xiaojing Cheng, Danqing Lei, Yanling Chen, Yanan Li, Jinliang Kong, Yiqiang Chen
The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling virulence factors and biofilm formation in Pseudomonas aeruginosa. QS-controlled biofilm formation by Pseudomonas aeruginosa in clinical settings has remained controversial due to emerging drug resistance; therefore, screening diverse compounds for anti-biofilm or anti-QS activities is important. This study demonstrates the ability of sub-minimum inhibitory concentrations (sub-MICs) of baicalin, an active natural compound extracted from the traditional Chinese medicinal Scutellaria baicalensis, to inhibit the formation of Pseudomonas aeruginosa biofilms and enhance the bactericidal effects of various conventional antibiotics in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28442545/peroxisome-proliferator-activated-receptor-%C3%AE-agonists-attenuate-biofilm-formation-by-pseudomonas-aeruginosa
#2
Brahmchetna Bedi, Nicholas M Maurice, Vincent T Ciavatta, K Sabrina Lynn, Zhihong Yuan, Samuel A Molina, Myungsoo Joo, William R Tyor, Joanna B Goldberg, Michael H Koval, C Michael Hart, Ruxana T Sadikot
Pseudomonas aeruginosa is a significant contributor to recalcitrant multidrug- resistant infections, especially in immunocompromised and hospitalized patients. The pathogenic profile of P. aeruginosa is related to its ability to secrete a variety of virulence factors and to promote biofilm formation. Quorum sensing (QS) is a mechanism wherein P. aeruginosa secretes small diffusible molecules, specifically acyl homo serine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm formation and virulence via interbacterial communication...
April 25, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28421612/prospective-bacterial-quorum-sensing-inhibitors-from-indian-medicinal-plant-extracts
#3
Bipransh Kumar Tiwary, Runu Ghosh, Saurav Moktan, Vivek Kumar Ranjan, Priyankar Dey, Dibakar Choudhury, Somit Dutta, Dipanwita Deb, Abhaya Prasad Das, Ranadhir Chakraborty
As virulence of many pathogenic bacteria is regulated by the phenomenon of quorum sensing (QS), the present study aimed to find the QS-inhibiting (QS-I) property (if any) in sixty-one Indian medicinal plants. The presence of QS-I compound in the leaf-extract was evaluated by its ability to inhibit production of pigment in Chromobacterium violaceum MTCC 2656 (violacein) and Pseudomonas aeruginosa MTCC 2297 (pyocyanin) or swarming of P. aeruginosa MTCC 2297. Extracts of three plants, Astilbe rivularis, Fragaria nubicola and Osbeckia nepalensis have shown a dose- dependent inhibition of violacein production with no negative effect on bacterial growth...
April 19, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28418096/expression-of-toll-like-receptors-in-t-lymphocytes-stimulated-with-n-3-oxododecanoyl-l-homoserine-lactone-from-pseudomonas-aeruginosa
#4
Lei Bao, Jialin Yu, Haiying Zhong, Daochao Huang, Qi Lu
The establishment of chronic Pseudomonas aeruginosa infections is correlated with the disturbance of the host immune system. The P. aeruginosa quorum-sensing molecule N-3-(oxododecanoyl)-L-homoserine lactone (3-O-C12-HSL) has the potential to modulate the host immune system. The immune system recognizes pathogens via toll-like receptors (TLRs). We found that 3-O-C12-HSL induced TLR changes in monocytes. However, the role of T cells in P. aeruginosa infection has not been delineated. In order to understand this activity, we examined whether 3-O-C12-HSL has an effect on the immune function and the expression of TLRs in T lymphocytes...
April 18, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28405399/strain-identification-and-quorum-sensing-inhibition-characterization-of-marine-derived-rhizobium-sp-nao1
#5
Hong Chang, Jin Zhou, Xiaoshan Zhu, Shenchen Yu, Lu Chen, Hui Jin, Zhonghua Cai
A novel strategy for combating pathogens is through the ongoing development and use of anti-quorum sensing (QS) treatments such as therapeutic bacteria or their anti-QS substances. Relatively little is known about the bacteria that inhabit the open ocean and of their potential anti-pathogenic attributes; thus, in an initiative to identify these types of therapeutic bacteria, planktonic microbes from the North Atlantic Ocean were collected, isolated, cultured and screened for anti-QS activity. Screening analysis identified one such strain, Rhizobium sp...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28396663/bacterial-secretant-from-pseudomonas-aeruginosa-dampens-inflammasome-activation-in-a-quorum-sensing-dependent-manner
#6
Jungmin Yang, Kang-Mu Lee, Sangjun Park, Yoeseph Cho, Eunju Lee, Jong-Hwan Park, Ok Sarah Shin, Junghyun Son, Sang Sun Yoon, Je-Wook Yu
Inflammasome signaling can contribute to host innate immune defense against bacterial pathogens such as Pseudomonas aeruginosa. However, bacterial evasion of host inflammasome activation is still poorly elucidated. Quorum sensing (QS) is a bacterial communication mechanism that promotes coordinated adaptation by triggering expression of a wide range of genes. QS is thought to strongly contribute to the virulence of P. aeruginosa, but the molecular impact of bacterial QS on host inflammasome defense is completely unknown...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28386534/scaffold-of-selenium-nanovectors-and-honey-phytochemicals-for-inhibition-of-pseudomonas-aeruginosa-quorum-sensing-and-biofilm-formation
#7
Prateeksha, Braj R Singh, M Shoeb, S Sharma, A H Naqvi, Vijai K Gupta, Brahma N Singh
Honey is an excellent source of polyphenolic compounds that are effective in attenuating quorum sensing (QS), a chemical process of cell-to-cell communication system used by the opportunistic pathogen Pseudomonas aeruginosa to regulate virulence and biofilm formation. However, lower water solubility and inadequate bioavailability remains major concerns of these therapeutic polyphenols. Its therapeutic index can be improved by using nano-carrier systems to target QS signaling potently. In the present study, we fabricated a unique drug delivery system comprising selenium nanoparticles (SeNPs; non-viral vectors) and polyphenols of honey (HP) for enhancement of anti-QS activity of HP against P...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28364274/quorum-quenching-properties-of-actinobacteria-isolated-from-malaysian-tropical-soils
#8
Kavimalar Devaraj, Geok Yuan Annie Tan, Kok-Gan Chan
In this study, a total of 147 soil actinobacterial strains were screened for their ability to inhibit response of Chromobacterium violaceum CV026 to short chain N-acyl homoserine lactone (AHL) which is a quorum sensing molecule. Of these, three actinobacterial strains showed positive for violacein inhibition. We further tested these strains for the inhibition of Pseudomonas aeruginosa PAO1 quorum sensing-regulated phenotypes, namely, swarming and pyocyanin production. The three strains were found to inhibit at least one of the quorum sensing-regulated phenotypes of PAO1...
March 31, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28351711/structure-based-virtual-screening-for-identification-of-potential-quorum-sensing-inhibitors-against-lasr-master-regulator-in-pseudomonas-aeruginosa
#9
Manmohit Kalia, Pradeep Kumar Singh, Vivek Kumar Yadav, Birendra Singh Yadav, Deepmala Sharma, Sahid Suhail Narvi, Ashutosh Mani, Vishnu Agarwal
Inter and intracellular communication in bacteria, which is known as quorum sensing (QS), is mediated by small diffusible signaling molecules known as autoinducers. QS regulates various virulence factors responsible for pathogenesis. Increasing resistance of microorganisms against traditional antibiotics has turned the focus towards the QS as it exerts less selective pressure preventing development of resistance among microorganisms. LasR, a transcription factor that controls QS in Pseudomonas aeruginosa, is an attractive therapeutic target for inhibitors...
March 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28350449/long-chained-4-aminoquinolines-as-quorum-sensing-inhibitors-in-serratia-marcescens-and-pseudomonas-aeruginosa
#10
Ivana Aleksić, Sandra Šegan, Filip Andric, Mario Zlatović, Ivana Moric, Dejan M Opsenica, Lidija Senerovic
Antibiotic resistance has become serious global threat to public health; therefore, the improved strategies and structurally novel antimicrobials are urgently needed to combat infectious diseases. Here we report a new type of highly potent 4-aminoquinoline derivatives as quorum sensing inhibitors in Serratia marcescens and Pseudomonas aeruginosa, exhibiting weak bactericidal activities (MIC > 400 μM). Through detailed structure-activity study we have identified 7-Cl and 7-CF3 substituted N-dodecylamino-4-aminoquinolines (5 and 10) as biofilm formation inhibitors with 50% biofilm inhibition at 69 μM and 63 μM in S...
March 28, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28338676/dirhamnolipids-secreted-from-pseudomonas-aeruginosa-modify-anjpegungal-susceptibility-of-aspergillus-fumigatus-by-inhibiting-%C3%AE-1-3-glucan-synthase-activity
#11
Benoit Briard, Vero Rasoldier, Perrine Bomme, Noureddine ElAouad, Catherine Guerreiro, Pierre Chassagne, Laetitia Muszkieta, Jean-Paul Latgé, Laurence Mulard, Anne Beauvais
Pseudomonas aeruginosa and Aspergillus fumigatus are the two microorganisms responsible for most of the chronic infections in cystic fibrosis patients. P. aeruginosa is known to produce quorum-sensing controlled rhamnolipids during chronic infections. Here we show that the dirhamnolipids secreted from P. aeruginosa (i) induce A. fumigatus to produce an extracellular matrix, rich in galactosaminogalactan, 1,8-dihydroxynaphthalene (DHN)- and pyo-melanin, surrounding their hyphae, which facilitates P. aeruginosa binding and (ii) inhibit A...
March 24, 2017: ISME Journal
https://www.readbyqxmd.com/read/28323149/the-effect-of-tobramycin-incorporated-with-bismuth-ethanedithiol-loaded-on-niosomes-on-the-quorum-sensing-and-biofilm-formation-of-pseudomonas-aeruginosa
#12
Faeze Mahdiun, Shahla Mansouri, Payam Khazaeli, Rasoul Mirzaei
Pseudomonas aeruginosa is an opportunistic pathogen, enable of causing infections especially in immunocompromised patients. Recently many isolates developed multiple drug resistance, resulting in treatment failure in serious infections. In this study, the effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm production by P. aeruginosa was evaluated. Thin layer hydration method with cholesterol (30%), Span 40 and Tween 40 were used to make niosomes...
March 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28294685/star-anise-illicium-verum-hook-f-as-quorum-sensing-and-biofilm-formation-inhibitor-on-foodborne-bacteria-study-in-milk
#13
Md Ramim Tanver Rahman, Zaixiang Lou, Jun Zhang, Fuhao Yu, Yakindra Prasad Timilsena, Caili Zhang, Yi Zhang, Amr M Bakry
Bacteria use quorum sensing (QS) systems to communicate with each other and regulate microbial group behavior, such as the secretion of virulence factors, including biofilm formation. In order to explore safe, edible agents, the potential of star anise (SA) as an anti-QS and antibiofilm agent and its possible application in milk safety were investigated. Staphylococcus aureus , Salmonella Typhimurium, Pseudomonas aeruginosa , and biosensor strain Chromobacterium violaceum were selected as test strains for QS, biofilm, and exopolysaccharide assays...
March 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28294414/evaluation-of-phytochemicals-from-medicinal-plants-of-myrtaceae-family-on-virulence-factor-production-by-pseudomonas-aeruginosa
#14
Khadar Syed Musthafa, Wipawadee Sianglum, Jongkon Saising, Sakkarin Lethongkam, Supayang Piyawan Voravuthikunchai
Virulence factors regulated by quorum sensing (QS) play a critical role in the pathogenesis of an opportunistic human pathogen, Pseudomonas aeruginosa in causing infections to the host. Hence, in the present work, the anti-virulence potential of the medicinal plant extracts and their derived phytochemicals from Myrtaceae family was evaluated against P. aeruginosa. In the preliminary screening of the tested medicinal plant extracts, Syzygium jambos and Syzygium antisepticum demonstrated a maximum inhibition in QS-dependent violacein pigment production by Chromobacterium violaceum DMST 21761...
March 15, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28273650/bioanalysis-of-pseudomonas-aeruginosa-alkyl-quinolone-signalling-molecules-in-infected-mouse-tissue-using-lc-ms-ms-and-its-application-to-a-pharmacodynamic-evaluation-of-mvfr-inhibition
#15
Paul Turnpenny, Anthony Padfield, Patrick Barton, Joanne Teague, Laurence G Rahme, Michael J Pucci, Robert Zahler, Aileen Rubio
Alkyl quinolone molecules 2-heptyl-4-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) are important quorum sensing signals, which play a mediatory role in the pathogenesis of acute and chronic Pseudomonas aeruginosa infection. A targeted approach inhibiting the bacterial 'multiple virulence factor regulon' (MvfR) protein complex, offers the possibility to block the synthesis of MvfR-dependant signal molecules. Here, a high throughput bioanalytical method was developed using LC-MS/MS detection for the selective determination of HHQ and PQS in mouse tissue homogenate, over a sensitive range of 1-5000 and 10-5000pg/mL, respectively...
May 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28261183/effect-of-quorum-quenching-lactonase-in-clinical-isolates-of-pseudomonas-aeruginosa-and-comparison-with-quorum-sensing-inhibitors
#16
Assia Guendouze, Laure Plener, Janek Bzdrenga, Pauline Jacquet, Benjamin Rémy, Mikael Elias, Jean-Philippe Lavigne, David Daudé, Eric Chabrière
Pseudomonas aeruginosa is a Gram negative pathogenic bacterium involved in many human infections including otitis, keratitis, pneumonia, and diabetic foot ulcers. P. aeruginosa uses a communication system, referred to as quorum sensing (QS), to adopt a group behavior by synchronizing the expression of certain genes. Among the regulated traits, secretion of proteases or siderophores, motility and biofilm formation are mainly involved in the pathogenicity. Many efforts have been dedicated to the development of quorum sensing inhibitors (QSI) and quorum quenching (QQ) agents to disrupt QS...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28255686/reducing-virulence-and-biofilm-of-pseudomonas-aeruginosa-by-potential-quorum-sensing-inhibitor-carotenoid-zeaxanthin
#17
Barış Gökalsın, Busecan Aksoydan, Burak Erman, Nüzhet Cenk Sesal
Pseudomonas aeruginosa can regulate its virulence gene expressions by using a signal system called quorum sensing. It is known that inhibition of quorum sensing can block biofilm formation and leave the bacteria defenseless. Therefore, it is necessary to determine natural sources to obtain potential quorum sensing inhibitors. This study aims to investigate an alternative treatment approach by utilizing the carotenoid zeaxanthin to reduce the expressions of P. aeruginosa virulence factors through quorum sensing inhibition...
March 2, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28236620/influence-of-huang-lian-jie-du-decoction-on-quorum-sensing-system-of-pseudomonas-aeruginosa
#18
Fei Xia, Lihua Ye, Ping Wang, Mingwei Zhang
Context • Pseudomonas aeruginosa (P aeruginosa) is an opportunistic and nosocomial, Gram-negative pathogen that is characteristic of quorum sensing (QS) modulation. QS inhibition (QSI) is considered to be a new approach to antimicrobial treatment that may reduce issues of antibiotic resistance. Traditional Chinese herbs have been recognized as a source of QSI. Objective • This study was intended to investigate whether the Huang Lian Jie Du decoction (HLJJD) possesses the ability to produce anti-QS activity...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28164039/quorum-sensing-n-acyl-homoserine-lactones-sdia-suppresses-escherichia-coli-pseudomonas-aeruginosa-conjugation-through-inhibiting-trai-expression
#19
Yang Lu, Jianming Zeng, Binning Wu, Shunmei E, Lina Wang, Renxin Cai, Ni Zhang, Youqiang Li, Xianzhang Huang, Bin Huang, Cha Chen
Conjugation is a key mechanism for horizontal gene transfer and plays an important role in bacterial evolution, especially with respect to antibiotic resistance. However, little is known about the role of donor and recipient cells in regulation of conjugation. Here, using an Escherichia coli (SM10λπ)-Pseudomonas aeruginosa (PAO1) conjugation model, we demonstrated that deficiency of lasI/rhlI, genes associated with generation of the quorum sensing signals N-acyl homoserine lactones (AHLs) in PAO1, or deletion of the AHLs receptor SdiA in the donor SM10λπ both facilitated conjugation...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28149169/anti-quorum-sensing-and-anti-biofilm-activity-of-amomum-tsaoko-amommum-tsao-ko-crevost-et-lemarie-on-foodborne-pathogens
#20
Md Ramim Tanver Rahman, Zaixiang Lou, Fuhao Yu, Peng Wang, Hongxin Wang
Cell-to-cell communication or quorum sensing (QS) leads to biofilm formation and causing other virulence factors which are extreme problems for food safety, biofilm related infectious diseases etc. This study evaluated the anti-QS activity of the Amomum tsaoko extract (0.5-4 mg/ml) by using Chromobacterium violaceum a biosensor strain and biofilm formation by crystal violate assay. Experimental results demonstrated that the overall yield of Amomum tsao-ko extract was 11.33 ± 0.3% (w/w). MIC for Staphylococcus aureus (Gram positive), Salmonella Typhimurium and Pseudomonas aeruginosa (Gram negative) was 1, 2 and 2 mg/ml, respectively...
February 2017: Saudi Journal of Biological Sciences
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