keyword
MENU ▼
Read by QxMD icon Read
search

Quorum sensing inhibition, Pseudomonas aeruginosa

keyword
https://www.readbyqxmd.com/read/29324344/anti-biofilm-effect-of-novel-thiazole-acid-analogs-against-pseudomonas-aeruginosa-through-iqs-pathways
#1
Shengrong Li, Siyu Chen, Jilin Fan, Zhen Cao, Weihao Ouyang, Ning Tong, Xin Hu, Jie Hu, Peishan Li, Zifeng Feng, Xi Huang, Yuying Li, Mingshan Xie, Ruikun He, Jingyi Jian, Biyuan Wu, Chen Xu, Weijian Wu, Jialiang Guo, Jing Lin, Pinghua Sun
IQS has been proven to be a new quorum sensing (QS) system against bacterial biofilm formation, which is activated in the common phosphate-limiting environment of infected tissues taking over the central las system. Up to now, numerous biofilm inhibitors which function by affecting traditional QS system have been reported. However, no compound has been reported to exert anti-biofilm activity through IQS system. Herein, various novel IQS derivatives were synthesized by the reaction of thiazole-4-carboxylic acid with different linear alcohols (R-OH) or amines (R-NH2)...
December 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29322006/attenuation-of-quorum-sensing-dependent-virulence-factors-and-biofilm-formation-by-medicinal-plants-against-antibiotic-resistant-pseudomonas-aeruginosa
#2
P Sankar Ganesh, V Ravishankar Rai
Pseudomonas aeruginosa use small signaling molecules such as acyl homoserine lactones (AHLs), which play an important role in release virulence factors and toxin for further establishment of host infection. Thus, involving with the QS system would provide alternative ways of preventing the pathogenicity. In the present study, totally six medicinal plants (Terminalia bellerica, Celastrus paniculatus, Kingiodendron pinnatum, Schleichera oleosa, Melastoma malabathricum, Garcinia gummi-gutta) were screened for anti-QS activity using biomonitor strain of Chromobacterium violaceum CV12472...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29290510/effect-of-nano-silver-nano-copper-deconex-and-benzalkonium-chloride-on-biofilm-formation-and-expression-of-transcription-regulatory-quorum-sensing-gene-rh1r-in-drug-resistance-pseudomonas-aeruginosa-burn-isolates
#3
Melika Gholamrezazadeh, Mohammad Reza Shakibaie, Fatemeh Monirzadeh, Shalaleh Masoumi, Zahra Hashemizadeh
BACKGROUND: Biofilm forming drug-resistant Pseudomonas aeruginosa are responsible for major death in burn center of different hospitals across the globe. OBJECTIVE: The aims of this study were to evaluate the effect of nano-silver (Ag), nano-copper (Cu), and two hospital disinfectants (deconex and benzalkonium chloride) on biofilm formation and expression of transcription regulatory quorum sensing gene rh1R in P. aeruginosa burn isolates. METHODS: 28 multidrug-resistant P...
December 28, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29288300/biogenic-synthesis-of-silver-nanoparticles-using-piper-betle-aqueous-extract-and-evaluation-of-its-anti-quorum-sensing-and-antibiofilm-potential-against-uropathogens-with-cytotoxic-effects-an-in-vitro-and-in-vivo-approach
#4
Ramanathan Srinivasan, Loganathan Vigneshwari, Tamilselvam Rajavel, Ravindran Durgadevi, Arunachalam Kannappan, Krishnaswamy Balamurugan, Kasi Pandima Devi, Arumugam Veera Ravi
Urinary tract infections are the utmost common bacterial infections caused by Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, and Serratia marcescens. These uropathogens resist the action of several antibiotics due to their ability to form biofilms. Most of these bacterial pathogens use the quorum sensing (QS) machinery to co-ordinate their cells and regulate several virulence factors and biofilm formation. On the other hand, the anti-quorum sensing (anti-QS) and antibiofilm potential of silver nanoparticles have been well reported against certain bacterial pathogens, but to the best of our knowledge, no report is available against the pathogenicity of uropathogens in particular S...
December 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29191704/microfouling-inhibition-of-human-nosocomial-pathogen-pseudomonas-aeruginosa-using-marine-cyanobacteria
#5
Felix LewisOscar, Chari Nithya, Sulaiman Ali Alharbi, Naiyf S Alharbi, Nooruddin Thajuddin
Pseudomonas aeruginosa is a Gram negative, opportunistic biofilm forming pathogenic bacterium which is developing as a serious problem worldwide. The pathogenicity of P. aeruginosa mainly depends upon biofilm and quorum sensing (QS) mechanism. Targeting biofilm and QS regulated factor will automatically reduce the pathogenicity of P. aeruginosa. Therefore it is compulsory to identify naturally derived biofilm and QS inhibitors against P. aeruginosa. In the present study Oscillatoria subuliformis, a marine cyanobacterium was used against the biofilm and QS of P...
November 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29178590/meloxicam-inhibits-biofilm-formation-and-enhances-antimicrobial-agents-efficacy-by-pseudomonas-aeruginosa
#6
Pengfei She, Yangxia Wang, Zhen Luo, Lihua Chen, Ruichen Tan, Yanle Wang, Yong Wu
Microbial biofilms are communities of surface-adhered cells enclosed in a matrix of extracellular polymeric substances. Bacterial cells in biofilm are 10~1,000-fold more resistant to antimicrobials than the planktonic cells. Burgeoning antibiotic resistance in Pseudomonas aeruginosa biofilm has necessitated the development of antimicrobial agents. Here, we have investigated the antibiofilm effect of meloxicam against P. aeruginosaPAO1 and its potential mechanisms. Further, we have explored whether meloxicam could enhance the susceptibility of bacterial biofilms to treatment with conventional antimicrobials...
November 27, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29151646/intracellular-synthesis-of-gold-nanoparticles-using-an-ectomycorrhizal-strain-em-1083-of-laccaria-fraterna-and-its-nanoanti-quorum-sensing-potential-against-pseudomonas-aeruginosa
#7
Sreeparna Samanta, Braj Raj Singh, Alok Adholeya
In this research work different shapes and sizes of gold nanoparticles (AuNPs) were synthesized through an intracellular biogenic approach, exploiting the chloroauric acid reducing and Au0 stabilizing potential of Laccaria fraterna EM-1083 mycelia. The intracellularly synthesized AuNPs exhibits anti-quorum sensing inhibitory potential against Pseudomonas aeruginosa. The synthesized AuNPs were characterized using UV-visible spectroscopy; transmission electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29135250/structure-activity-relationships-of-6-and-8-gingerol-analogs-as-anti-biofilm-agents
#8
Hyunsuk Choi, So-Young Ham, Eunji Cha, Yujin Shin, Han-Shin Kim, Jeong Kyu Bang, Sang-Hyun Son, Hee-Deung Park, Youngjoo Byun
Pseudomonas aeruginosa is a causative agent of chronic infections in immunocompromised patients. Disruption of quorum sensing circuits is an attractive strategy for treating diseases associated with P. aeruginosa infection. In this study, we designed and synthesized a series of gingerol analogs targeting LasR, a master regulator of quorum sensing networks in P. aeruginosa. Structure-activity relationship studies showed that a hydrogen-bonding interaction in the head section, stereochemistry and rotational rigidity in the middle section, and optimal alkyl chain length in the tail section are important factors for the enhancement of LasR-binding affinity and for the inhibition of biofilm formation...
November 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29130180/qualitative-and-quantitative-determination-of-quorum-sensing-inhibition-in-vitro
#9
Tim Holm Jakobsen, Maria Alhede, Louise Dahl Hultqvist, Thomas Bjarnsholt, Michael Givskov
The formation of biofilms in conjunction with quorum sensing (QS) regulated expression of virulence by opportunistic pathogens contributes significantly to immune evasion and tolerance to a variety of antimicrobial treatments. The present protocol describes methods to determine the in vitro efficacy of potential QS inhibitors (QSIs). Work on Pseudomonas aeruginosa has shown that chemical blockage of QS is a promising new antimicrobial strategy. Several live bacterial reporter systems have been developed to screen extracts and pure compounds for QSI activity...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29129053/research-on-chemical-composition-and-biological-properties-including-anti-quorum-sensing-activity-of-angelica-pancicii-vandas-aerial-parts-and-roots
#10
Ksenija S Mileski, Snežana S Trifunović, Ana D Ćirić, Željana M Šakić, Mihailo S Ristić, Nina M Todorović, Vlado S Matevski, Petar D Marin, Vele V Tesevic, Ana M Džamić
The essential oil, different extracts and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%) and β-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicated coumarins as the main constituents...
November 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29104645/combined-effect-of-linolenic-acid-and-tobramycin-on-pseudomonas-aeruginosa-biofilm-formation-and-quorum-sensing
#11
Warren Chanda, Thomson Patrick Joseph, Arshad Ahmed Padhiar, Xuefang Guo, Liu Min, Wendong Wang, Sainyugu Lolokote, Anhong Ning, Jing Cao, Min Huang, Mintao Zhong
Pseudomonas aeruginosa is a ubiquitous Gram negative opportunistic pathogen capable of causing severe nosocomial infections in humans, and tobramycin is currently used to treat P. aeruginosa associated lung infections. Quorum sensing regulates biofilm formation which allows the bacterium to result in fatal infections forcing clinicians to extensively use antibiotics to manage its infections leading to emerging multiple drug resistant strains. As a result, tobramycin is also becoming resistant. Despite extensive studies on drug discovery to alleviate microbial drug resistance, the continued microbial evolution has forced researchers to focus on screening various phytochemicals and dietary compounds for antimicrobial potential...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29098138/antiquorum-sensing-activity-of-silver-nanoparticles-in-p-aeruginosa-an-in-silico-study
#12
Syed Ghazanfar Ali, Mohammad Azam Ansari, Qazi Mohd Sajid Jamal, Haris M Khan, Mohammad Jalal, Hilal Ahmad, Abbas Ali Mahdi
Pseudomonas aeruginosa an opportunistic pathogen regulates its virulence through Quorum sensing (QS) mechanism comprising of Las and Rhl system. Targeting of QS mechanism could be an ideal strategy to combat infection caused by P. aeruginosa. Silver nanoparticles (AgNPs) have been broadly applied as antimicrobial agents against a number of pathogenic bacterial and fungal strains, but have not been reported as an anti-QS agent. Therefore, the aim of present work was to show the computational analysis for the interaction of AgNPs with the QS system using an In silico approach...
2017: In Silico Pharmacology
https://www.readbyqxmd.com/read/29042302/attenuation-of-pseudomonas-aeruginosa-quorum-sensing-virulence-and-biofilm-formation-by-extracts-of-andrographis-paniculata
#13
Malabika Banerjee, Soumitra Moulick, Kunal Kumar Bhattacharya, Debaprasad Parai, Subrata Chattopadhyay, Samir Kumar Mukherjee
Quorum-sensing (QS) is known to play an essential role in regulation of virulence factors and toxins during Pseudomonas aeruginosa infection which may frequently cause antibiotic resistance and hostile outcomes of inflammatory injury. Therefore, it is an urgent need to search for a novel agent with low risk of resistance development that can target QS and inflammatory damage prevention as well. Andrographis paniculata, a herbaceous plant under the family Acanthaceae, native to Asian countries and also cultivated in Scandinavia and some parts of Europe, has a strong traditional usage with its known antibacterial, anti-inflammatory, antipyretic, antiviral and antioxidant properties...
October 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29038255/studies-of-pseudomonas-aeruginosa-mutants-indicate-pyoverdine-as-the-central-factor-in-inhibition-of-aspergillus-fumigatus-biofilm
#14
Gabriele Sass, Hasan Nazik, John Penner, Hemi Shah, Shajia Rahman Ansari, Karl V Clemons, Marie-Christine Groleau, Anna-Maria Dietl, Paolo Visca, Hubertus Haas, Eric Déziel, David A Stevens
Pseudomonas aeruginosa (Pa) and Aspergillus fumigatus (Af) are common opportunistic bacterial and fungal pathogens, respectively. They often co-exist in airways of immunocompromised patients and individuals with cystic fibrosis, where they form biofilms and cause acute and chronic illnesses. Hence the interactions between them have long been of interest, and it is known that Pa can inhibit Af in vitro We have approached the definition of the inhibitory Pa molecules by studying 24 Pa mutants, with various virulence genes deleted, for their ability to inhibit Af biofilms...
October 16, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28993916/antimicrobial-metabolites-from-saraca-asoca-impairs-the-membrane-transport-system-and-quorum-sensing-system-in-pseudomonas-aeruginosa
#15
Preeti Jain, Amit Nale, Rajesh Dabur
This study was conducted to explore the antimicrobial mechanism of metabolites from Saraca asoca (SA1) using differential proteomics and metabolic profile of Pseudomonas aeruginosa after treatment with effective sub-MIC dose of 312 µg/mL. SA1 fraction was found to contain antibacterial metabolites catechol, protocatechuic acid, and epigallocatechin gallate. Proteome analysis revealed 33 differentially expressed proteins after SA1 treatment. Protein network analysis showed that SA1 treatment upregulated the DNA topological and metabolic processes...
October 9, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28993333/antibiotics-promote-escherichia-coli-pseudomonas-aeruginosa-conjugation-through-inhibiting-quorum-sensing
#16
Yang Lu, Jianming Zeng, Linjing Wang, Kai Lan, E Shunmei, Lina Wang, Qian Xiao, Qiang Luo, Xianzhang Huang, Bin Huang, Cha Chen
The effect of antibiotics on horizontal gene transfer is controversial and the underlying mechanism remains poorly understood. Here, using E. coli SM10λπ which carries a chromosomally integrated RP4 plasmid as donor strain, we investigated the effect of antibiotics on conjugational transfer of a mobilizable gentamicin (Gm) resistance plasmid. The results showed that exposure to gentamicin that may restrict the survival of recipient cells significantly enhanced SM10λπ-P. aeruginosa (PAO1) conjugation, which was attenuated by deficiency of lasI/rhlI, genes associated with generation of the quorum sensing signals N-acyl homoserine lactones (AHLs) in PAO1, or deletion of the AHLs receptor SdiA in SM10λπ...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28983655/mechanistic-understanding-of-phenyllactic-acid-mediated-inhibition-of-quorum-sensing-and-biofilm-development-in-pseudomonas-aeruginosa
#17
Maitrayee Chatterjee, Sharon D'Morris, Vinod Paul, Sruthi Warrier, Anil Kumar Vasudevan, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Bindhu Paul-Prasanth, C Gopi Mohan, Raja Biswas
Pseudomonas aeruginosa depends on its quorum sensing (QS) system for its virulence factors' production and biofilm formation. Biofilms of P. aeruginosa on the surface of indwelling catheters are often resistant to antibiotic therapy. Alternative approaches that employ QS inhibitors alone or in combination with antibiotics are being developed to tackle P. aeruginosa infections. Here, we have studied the mechanism of action of 3-Phenyllactic acid (PLA), a QS inhibitory compound produced by Lactobacillus species, against P...
October 5, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28939255/inhibition-of-quorum-sensing-related-virulence-factors-of-pseudomonas-aeruginosa-by-pyridoxal-lactohydrazone
#18
Azam Heidari, Nader Noshiranzadeh, Fakhri Haghi, Rahman Bikas
Pseudomonas aeruginosa quorum sensing (QS) system is a cell to cell signaling mechanism that regulates virulence factors and pathogenicity. Therefore, the QS system in P. aeruginosa may be an important target for pharmacological intervention. The present study aimed to investigate the effects of sub-MIC concentrations of (S,E)-2-hydroxy-N-(3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)propane hydrazide (pyridoxal lactohydrazone) against P. aeruginosa QS related virulence factors. We investigated the effect of sub-MIC concentrations of chiral pyridoxal lactohydrazone, which formed by the reaction of chiral lactic acid hydrazide and pyridoxal (one form of Vitamin B6) as bioactive reagents, on virulence factors...
September 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28930136/methanol-extract-from-anogeissus-leiocarpus-dc-guill-et-perr-combretaceae-stem-bark-quenches-the-quorum-sensing-of-pseudomonas-aeruginosa-pao1
#19
Vincent Ouedraogo, Martin Kiendrebeogo
Background: Due to its extensive arsenal of virulence factors and inherent resistance to antibiotics, Pseudomonas aeruginosa is a threat particularly in immunocompromised patients. Considering the central role of quorum sensing in the production of virulence factors, inhibition of bacterial communication mechanism constitute an opportunity to attenuate pathogenicity of bacteria resistant to available antibiotics. Our study aimed to assess the anti-quorum sensing activity of Anogeissus leiocarpus, traditionally used in Burkina Faso, for the treatment of infected burn wounds...
October 6, 2016: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28928721/onion-peel-ethylacetate-fraction-and-its-derived-constituent-quercetin-4-o-%C3%AE-d-glucopyranoside-attenuates-quorum-sensing-regulated-virulence-and-biofilm-formation
#20
Hanan M Al-Yousef, Atallah F Ahmed, Nasser A Al-Shabib, Sameen Laeeq, Rais A Khan, Md T Rehman, Ali Alsalme, Mohamed F Al-Ajmi, Mohammad S Khan, Fohad M Husain
The resistance and pathogenesis of bacteria could be related to their ability to sense and respond to population density, termed quorum sensing (QS). Inhibition of the QS system is considered as a novel strategy for the development of antipathogenic agents, especially for combating drug-resistant bacterial infections. In the present study, the anti-QS activity of Onion peel ethylacetate fraction (ONE) was tested against Chromobacterium violaceum CV12472 and Pseudomonas aeruginosa PAO1. ONE inhibit the QS-mediated virulence factors production such as violacein in C...
2017: Frontiers in Microbiology
keyword
keyword
41863
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"