keyword
MENU ▼
Read by QxMD icon Read
search

Quorum sensing, Quorum quenching, Pseudomonas aeruginosa

keyword
https://www.readbyqxmd.com/read/29775211/proanthocyanidins-will-they-effectively-restrain-conspicuous-bacterial-strains-devolving-on-urinary-tract-infection
#1
REVIEW
Venkataseshan Jagannathan, Pragasam Viswanathan
Struvite or infection stones are one of the major clinical burdens among urinary tract infection, which occur due to the interaction between microbes and urine mineral components. Numerous urinary tract infection (UTI) causing microbes regulate through biofilm formation for survival from host defense, it is often found difficult in its eradication with simple anti-microbial agents and also the chance of recurrence and resistance development is significantly high. Cranberry consumption and maintenance of urinary tract health have been supported by clinical, epidemiological, and mechanistic studies...
May 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29755959/pvdq-quorum-quenching-acylase-attenuates-pseudomonas-aeruginosa-virulence-in-a-mouse-model-of-pulmonary-infection
#2
Putri D Utari, Rita Setroikromo, Barbro N Melgert, Wim J Quax
Pseudomonas aeruginosa is the predominant pathogen in pulmonary infections associated with cystic fibrosis. Quorum sensing (QS) systems regulate the production of virulence factors and play an important role in the establishment of successful P. aeruginosa infections. Inhibition of the QS system (termed quorum quenching) renders the bacteria avirulent thus serving as an alternative approach in the development of novel antibiotics. Quorum quenching in Gram negative bacteria can be achieved by preventing the accumulation of N -acyl homoserine lactone (AHL) signaling molecule via enzymatic degradation...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29662232/characterization-of-aiik-an-ahl-lactonase-from-kurthia-huakui-lam0618-t-and-its-application-in-quorum-quenching-on-pseudomonas-aeruginosa-pao1
#3
Weiwei Dong, Jie Zhu, Xiang Guo, Delong Kong, Qi Zhang, Yiqing Zhou, Xiaoyang Liu, Shumiao Zhao, Zhiyong Ruan
N-Acyl homoserine lactones (AHLs) act as the key quorum sensing (QS) signal molecules in gram-negative bacteria, which coordinates gene expression and then activates various processes, including biofilm formation and production of virulence factors in some pathogens. Quorum quenching (QQ), which is the inactivation of the signal molecules by means of enzymatic degradation or modification, inhibits the processes of QS rather than killing the pathogens and is a promising antipathogenic strategy to control the bacterial pathogens...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29616198/regulation-of-nicotine-tolerance-by-quorum-sensing-and-high-efficiency-of-quorum-quenching-under-nicotine-stress-in-pseudomonas-aeruginosa-pao1
#4
Huiming Tang, Yunyun Zhang, Yifan Ma, Mengmeng Tang, Dongsheng Shen, Meizhen Wang
Quorum sensing (QS) regulates the behavior of bacterial populations and promotes their adaptation and survival under stress. As QS is responsible for the virulence of vast majority of bacteria, quorum quenching (QQ), the interruption of QS, has become an attractive therapeutic strategy. However, the role of QS in stress tolerance and the efficiency of QQ under stress in bacteria are seldom explored. In this study, we demonstrated that QS-regulated catalase (CAT) expression and biofilm formation help Pseudomonas aeruginosa PAO1 resist nicotine stress...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29348452/combination-therapy-strategy-of-quorum-quenching-enzyme-and-quorum-sensing-inhibitor-in-suppressing-multiple-quorum-sensing-pathways-of-p-aeruginosa
#5
July Fong, Chaodong Zhang, Renliang Yang, Zhao Zhi Boo, Soon Keat Tan, Thomas E Nielsen, Michael Givskov, Xue-Wei Liu, Wu Bin, Haibin Su, Liang Yang
The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would mitigate the increase of classical resistance mechanism. Many bacteria employ quorum sensing (QS) to govern the production of virulence factors and formation of drug-resistant biofilms. Targeting the mechanism of QS has proven to be a functional alternative to conventional antibiotic control of infections. However, the presence of multiple QS systems in individual bacterial species poses a challenge to this approach...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/28983655/mechanistic-understanding-of-phenyllactic-acid-mediated-inhibition-of-quorum-sensing-and-biofilm-development-in-pseudomonas-aeruginosa
#6
Maitrayee Chatterjee, Sharon D'Morris, Vinod Paul, Sruthi Warrier, Anil Kumar Vasudevan, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Bindhu Paul-Prasanth, C Gopi Mohan, Raja Biswas
Pseudomonas aeruginosa depends on its quorum sensing (QS) system for its virulence factors' production and biofilm formation. Biofilms of P. aeruginosa on the surface of indwelling catheters are often resistant to antibiotic therapy. Alternative approaches that employ QS inhibitors alone or in combination with antibiotics are being developed to tackle P. aeruginosa infections. Here, we have studied the mechanism of action of 3-Phenyllactic acid (PLA), a QS inhibitory compound produced by Lactobacillus species, against P...
October 5, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28930136/methanol-extract-from-anogeissus-leiocarpus-dc-guill-et-perr-combretaceae-stem-bark-quenches-the-quorum-sensing-of-pseudomonas-aeruginosa-pao1
#7
Vincent Ouedraogo, Martin Kiendrebeogo
Background: Due to its extensive arsenal of virulence factors and inherent resistance to antibiotics, Pseudomonas aeruginosa is a threat particularly in immunocompromised patients. Considering the central role of quorum sensing in the production of virulence factors, inhibition of bacterial communication mechanism constitute an opportunity to attenuate pathogenicity of bacteria resistant to available antibiotics. Our study aimed to assess the anti-quorum sensing activity of Anogeissus leiocarpus, traditionally used in Burkina Faso, for the treatment of infected burn wounds...
October 6, 2016: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28920855/pfma-a-novel-quorum-quenching-n-acylhomoserine-lactone-acylase-from-pseudoalteromonas-flavipulchra
#8
Na Liu, Min Yu, Youbin Zhao, Jingguang Cheng, Ke An, Xiao-Hua Zhang
Many bacteria, such as Proteobacteria, Cyanobacteria and Bacteroidetes, use N-acylhomoserine lactones (AHLs) as quorum-sensing (QS) signal molecules for communication. Enzymatic degradation of AHLs, such as AHL acylase and AHL lactonase, can degrade AHLs (quorum quenching, QQ) to attenuate or disarm the virulence of pathogens. QQ is confirmed to be common in marine bacterial communities. Many genes encoding AHL acylases are found in marine bacteria and metagenomic collections, but only a few of these have been characterized in detail...
September 18, 2017: Microbiology
https://www.readbyqxmd.com/read/28462048/pitfalls-associated-with-evaluating-enzymatic-quorum-quenching-activity-the-case-of-moml-and-its-effect-on-pseudomonas-aeruginosa-and-acinetobacter-baumannii-biofilms
#9
Yunhui Zhang, Gilles Brackman, Tom Coenye
BACKGROUND: The enzymatic degradation of quorums sensing (QS) molecules (called quorum quenching, QQ) has been considered as a promising anti-virulence therapy to treat biofilm-related infections and combat antibiotic resistance. The recently-discovered QQ enzyme MomL has been reported to efficiently degrade different N -acyl homoserine lactones (AHLs) of various Gram-negative pathogens. Here we investigated the effect of MomL on biofilms formed by two important nosocomial pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii ...
2017: PeerJ
https://www.readbyqxmd.com/read/28364274/quorum-quenching-properties-of-actinobacteria-isolated-from-malaysian-tropical-soils
#10
Kavimalar Devaraj, Geok Yuan Annie Tan, Kok-Gan Chan
In this study, a total of 147 soil actinobacterial strains were screened for their ability to inhibit response of Chromobacterium violaceum CV026 to short chain N-acyl homoserine lactone (AHL) which is a quorum sensing molecule. Of these, three actinobacterial strains showed positive for violacein inhibition. We further tested these strains for the inhibition of Pseudomonas aeruginosa PAO1 quorum sensing-regulated phenotypes, namely, swarming and pyocyanin production. The three strains were found to inhibit at least one of the quorum sensing-regulated phenotypes of PAO1...
August 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28261183/effect-of-quorum-quenching-lactonase-in-clinical-isolates-of-pseudomonas-aeruginosa-and-comparison-with-quorum-sensing-inhibitors
#11
Assia Guendouze, Laure Plener, Janek Bzdrenga, Pauline Jacquet, Benjamin Rémy, Mikael Elias, Jean-Philippe Lavigne, David Daudé, Eric Chabrière
Pseudomonas aeruginosa is a Gram negative pathogenic bacterium involved in many human infections including otitis, keratitis, pneumonia, and diabetic foot ulcers. P. aeruginosa uses a communication system, referred to as quorum sensing (QS), to adopt a group behavior by synchronizing the expression of certain genes. Among the regulated traits, secretion of proteases or siderophores, motility and biofilm formation are mainly involved in the pathogenicity. Many efforts have been dedicated to the development of quorum sensing inhibitors (QSI) and quorum quenching (QQ) agents to disrupt QS...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28018312/enzyme-mediated-quenching-of-the-pseudomonas-quinolone-signal-pqs-promotes-biofilm-formation-of-pseudomonas-aeruginosa-by-increasing-iron-availability
#12
Beatrix Tettmann, Christine Niewerth, Frank Kirschhöfer, Anke Neidig, Andreas Dötsch, Gerald Brenner-Weiss, Susanne Fetzner, Joerg Overhage
The 2-alkyl-3-hydroxy-4(1H)-quinolone 2,4-dioxygenase HodC was previously described to cleave the Pseudomonas quinolone signal, PQS, which is exclusively used in the complex quorum sensing (QS) system of Pseudomonas aeruginosa, an opportunistic pathogen employing QS to regulate virulence and biofilm development. Degradation of PQS by exogenous addition of HodC to planktonic cells of P. aeruginosa attenuated production of virulence factors, and reduced virulence in planta. However, proteolytic cleavage reduced the efficacy of HodC...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27933456/penicillin-v-acylases-from-gram-negative-bacteria-degrade-n-acylhomoserine-lactones-and-attenuate-virulence-in-pseudomonas-aeruginosa
#13
Avinash Vellore Sunder, Putri Dwi Utari, Sureshkumar Ramasamy, Ronald van Merkerk, Wim Quax, Archana Pundle
Virulence pathways in gram-negative pathogenic bacteria are regulated by quorum sensing mechanisms, through the production and sensing of N-acylhomoserine lactone (AHL) signal molecules. Enzymatic degradation of AHLs leading to attenuation of virulence (quorum quenching) could pave the way for the development of new antibacterials. Penicillin V acylases (PVAs) belong to the Ntn hydrolase superfamily, together with AHL acylases. PVAs are exploited widely in the pharmaceutical industry, but their role in the natural physiology of their native microbes is not clearly understood...
March 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27634359/phytochemicals-as-effective-quorum-quenchers-against-bacterial-communication
#14
Sivaramakrishnan Subramaniyan, Sasikumar Divyasree, Girija Sadasivan Sandhia
BACKGROUND: Quorum sensing or the bacterial information flow in an orchestrated manner is an essential feature of many pathogenic bacteria. Quorum quenching molecules (QQ) can inhibit the growth of such bacteria. OBJECTIVE: The purpose of this study is to evaluate the potential of plant extracts as quorum quenchers and monitor the recent patents. METHODS: Many available reports and patents are on synthetic ligand molecules or even compounds isolated from cyanobacteria (Honaucin A) and other microorganisms inhibiting quorum sensing molecules...
2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27623343/engineering-soluble-human-paraoxonase-2-for-quorum-quenching
#15
Xin Cathy Li, Christopher Wang, Ashok Mulchandani, Xin Ge
Many pathogenic bacteria utilize quorum sensing (QS) systems to regulate the expression of their virulence genes and promote the formation of biofilm, which renders pathogens with extreme resistance to conventional antibiotic treatments. As a novel approach for attenuating antibiotic resistance and in turn fighting chronic infections, enzymatic inactivation of QS signaling molecules, such as N-acyl homoserine lactones (AHLs), holds great promises. Instead of using bacterial lactonases that can evoke immune response when administered, we focus on the human paraoxonase 2 (huPON2)...
November 18, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27400878/antimicrobial-and-anti-quorum-sensing-activities-of-selected-medicinal-plants-of-ethiopia-implication-for-development-of-potent-antimicrobial-agents
#16
Ketema Bacha, Yinebeb Tariku, Fisseha Gebreyesus, Shibru Zerihun, Ali Mohammed, Nancy Weiland-Bräuer, Ruth A Schmitz, Mulugeta Mulat
BACKGROUND: Traditional medicinal plants have been used as an alternative medicine in many parts of the world, including Ethiopia. There are many documented scientific reports on antimicrobial activities of the same. To our knowledge, however, there is no report on the anti-Quorum Sensing (Quorum Quenching, QQ) potential of traditional Ethiopian medicinal plants. As many of the opportunistic pathogenic bacteria depend on Quorum Sensing (QS) systems to coordinate their virulence expression, interference with QS could be a novel approach to control bacterial infections...
July 11, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27238723/paraoxonases-1-2-and-3-what-are-their-functions
#17
Clement E Furlong, Judit Marsillach, Gail P Jarvik, Lucio G Costa
Paraoxonase-1 (PON1), an esterase/lactonase primarily associated with plasma high-density lipoprotein (HDL), was the first member of this family of enzymes to be characterized. Its name was derived from its ability to hydrolyze paraoxon, the toxic metabolite of the insecticide parathion. Related enzymes PON2 and PON3 were named from their evolutionary relationship with PON1. Mice with each PON gene knocked out were generated at UCLA and have been key for elucidating their roles in organophosphorus (OP) metabolism, cardiovascular disease, innate immunity, obesity, and cancer...
November 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27221658/gqqa-a-novel-protein-in-komagataeibacter-europaeus-involved-in-bacterial-quorum-quenching-and-cellulose-formation
#18
Maria José Valera, Albert Mas, Wolfgang R Streit, Estibaliz Mateo
BACKGROUND: We report on the functional screening and identification of an active quorum quenching (QQ) gene in the Komagataeibacter europaeus strain CECT 8546, which is a member of the acetic acid bacteria (AAB). RESULTS: Using a previously published screening protocol (Schipper et al., in Appl Environ Microbiol 75:224-233, 2009. doi: 10.1128/AEM.01389-08 ) for QQ genes, we identified a single gene, designated gqqA, that interfered strongly with bacterial quorum sensing (QS) in various reporter strains...
May 24, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/26539190/inhibiting-n-acyl-homoserine-lactone-synthesis-and-quenching-pseudomonas-quinolone-quorum-sensing-to-attenuate-virulence
#19
REVIEW
Kok-Gan Chan, Yi-Chia Liu, Chien-Yi Chang
Bacteria sense their own population size, tune the expression of responding genes, and behave accordingly to environmental stimuli by secreting signaling molecules. This phenomenon is termed as quorum sensing (QS). By exogenously manipulating the signal transduction bacterial population behaviors could be controlled, which may be done through quorum quenching (QQ). QS related regulatory networks have been proven their involvement in regulating many virulence determinants in pathogenic bacteria in the course of infections...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26319870/rhodococcus-erythropolis-bg43-genes-mediating-pseudomonas-aeruginosa-quinolone-signal-degradation-and-virulence-factor-attenuation
#20
Christine Müller, Franziska S Birmes, Christian Rückert, Jörn Kalinowski, Susanne Fetzner
Rhodococcus erythropolis BG43 is able to degrade the Pseudomonas aeruginosa quorum sensing signal molecules PQS (Pseudomonas quinolone signal) [2-heptyl-3-hydroxy-4(1H)-quinolone] and HHQ [2-heptyl-4(1H)-quinolone] to anthranilic acid. Based on the hypothesis that degradation of HHQ might involve hydroxylation to PQS followed by dioxygenolytic cleavage of the heterocyclic ring and hydrolysis of the resulting N-octanoylanthranilate, the genome was searched for corresponding candidate genes. Two gene clusters, aqdA1B1C1 and aqdA2B2C2, each predicted to code for a hydrolase, a flavin monooxygenase, and a dioxygenase related to 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase, were identified on circular plasmid pRLCBG43 of strain BG43...
November 2015: Applied and Environmental Microbiology
keyword
keyword
41862
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"