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Diabetes diastolic dysfunction

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https://www.readbyqxmd.com/read/28412852/transitional-hemodynamics-in-infants-of-diabetic-mothers-by-targeted-neonatal-echocardiography-electrocardiography-and-peripheral-flow-study
#1
Ingrid Anne Mandy Schierz, Giuseppa Pinello, Ettore Piro, Mario Giuffrè, Simona La Placa, Giovanni Corsello
OBJECTIVE: Metabolic alterations of intrauterine environment in diabetes mellitus (DM) lead to fetal cardiac dysfunctions that can persist after birth. The aim of the study was to assess the cardiovascular adaptation in infants born to diabetic mothers (IDM) with different degrees of glycometabolic control, in relation to revised guidelines for diagnosis of DM and quality improvements in neonatal care. MATERIALS AND METHODS: An observational case-control study was conducted on IDM with gestational, type 1, and type 2 DM...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28411073/arterial-stiffness-and-elevated-left-ventricular-filling-pressure-in-patients-at-risk-for-the-development-or-a-previous-diagnosis-of-hf-a-subgroup-analysis-from-the-diast-chf-study
#2
Claus Lüers, Tobias Daniel Trippel, Sebastian Seeländer, Rolf Wachter, Gerd Hasenfuss, Ruhdja Lindhorst, Anna Bobenko, Kathleen Nolte, Burkert Pieske, Frank Edelmann
Left ventricular filling pressure (LVFP) is a marker for diastolic dysfunction and heart failure (HF) with preserved ejection fraction (pEF). The interaction between arterial stiffness (AS) and elevated LVFP has not been sufficiently investigated. In 257 patients with preserved left ventricular ejection fraction (mean age: 66 years, 53% female, mean left ventricular ejection fraction: 61%) and at least one cardiovascular risk factor (eg, hypertension and diabetes) for the development of HF or a previous diagnosis of HF, LVFP was estimated in accordance with the recommendations of the American Society of Echocardiography (elevated when E/e' ≥ 13, left atrial volume index ≥ 34 mL/m(2))...
March 27, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28407661/effect-of-saxagliptin-on-circulating-endothelial-progenitor-cells-and-endothelial-function-in-newly-diagnosed-type-2-diabetic-patients
#3
Fang Li, Jiachao Chen, Fei Leng, Zhiqiang Lu, Yan Ling
Endothelial dysfunction is associated with the risk of cardiovascular complications in diabetic patients. Endothelial progenitor cells (EPCs) and flow-mediated dilation (FMD) are common markers of endothelial function. In this study, we aim to investigate whether the DPP-4 inhibitor saxagliptin modulate EPCs number and FMD in newly diagnosed, treatment-naive type 2 diabetic patients. This was a controlled, randomized, open-label clinical trial. Saxagliptin group and metformin group consumed either saxagliptin 5 mg per day or metformin 1 500 mg per day respectively for 12 weeks...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28400931/evaluation-of-cardiac-functions-in-children-and-adolescents-with-type-1-diabetes
#4
Faten M Abd-El Aziz, Shereen Abdelghaffar, Eman M Hussien, Aya M Fattouh
BACKGROUND: Cardiac dysfunction in patients with type 1 diabetes (T1D) represents one of the serious complications. To evaluate the cardiac function in children with T1D by conventional echocardiography and tissue Doppler imaging (TDI). METHODS: The study included 40 T1D patients (age between 6 and 16 years) with > 5 years duration of diabetes and 42 healthy control children. The patients were subjected to clinical evaluation and laboratory investigations [glycosylated hemoglobin A1c (HbA1c), serum lipids and lipoproteins]...
March 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28395010/inflammation-and-metabolic-cardiomyopathy
#5
Kazuhiko Nishida, Kinya Otsu
Excessive feeding is associated with an increase in the incidence of chronic metabolic diseases, such as obesity, insulin resistance, and type 2 diabetes. Metabolic disturbance induces chronic low-grade inflammation in metabolically-important organs, such as the liver and adipose tissue. Many of the inflammatory signalling pathways are directly triggered by nutrients. The pro-inflammatory mediators in adipocytes and macrophages infiltrating adipose tissue promote both local and systemic pro-inflammatory status...
March 15, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28394363/interleukin-18-mediates-cardiac-dysfunction-induced-by-western-diet-independent-of-obesity-and-hyperglycemia-in-the-mouse
#6
S Carbone, P J H Lee, A G Mauro, E Mezzaroma, R Buzzetti, B Van Tassell, A Abbate, S Toldo
Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized inflammatory mechanisms. We hypothesized that the detrimental cardiac effects of WD are mediated by interleukin-18 (IL-18), pro-inflammatory cytokine linked to cardiac dysfunction. C57BL/6J wild-type male mice and IL-18 knockout male mice were fed high-saturated fat and high-sugar diet for 8 weeks...
April 10, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28374918/left-atrial-volume-and-function-in-patients-with-cardiac-syndrome-x-assessed-by-real-time-three-dimensional-echocardiography
#7
Nusret Acıkgoz, Julide Yagmur, Ertugrul Kurtoglu, Necip Ermis, Mehmet Cansel
OBJECTIVE: The aim of this study was to evaluate left atrial (LA) volume and function using real time three-dimensional echocardiography (RT3DE) in patients with cardiac syndrome X (CSX). METHODS: Fifty patients with CSX (28 females; mean age 50.9±10.9 years) and 50 age- and gender-matched healthy controls (30 females; mean age 52.3±9.8 years) who had negative treadmill exercise test and normal coronary arteries on invasive coronary angiography were included in the study...
April 4, 2017: Echocardiography
https://www.readbyqxmd.com/read/28344129/role-of-microrna-in-diabetic-cardiomyopathy-from-mechanism-to-intervention
#8
REVIEW
Rui Guo, Sreejayan Nair
Diabetic cardiomyopathy is a chronic and irreversible heart complication in diabetic patients, and is characterized by complex pathophysiologic events including early diastolic dysfunction, cardiac hypertrophy, ventricular dilation and systolic dysfunction, eventually resulting in heart failure. Despite these characteristics, the underlying mechanisms leading to diabetic cardiomyopathy are still elusive. Recent studies have implicated microRNA, a small and highly conserved non-coding RNA molecule, in the etiology of diabetes and its complications, suggesting a potentially novel approach for the diagnosis and treatment of diabetic cardiomyopathy...
March 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28338005/the-association-between-diffuse-myocardial-fibrosis-on-cardiac-magnetic-resonance-t1-mapping-and-myocardial-dysfunction-in-diabetic-rabbits
#9
Mu Zeng, Yingyan Qiao, Zhaoying Wen, Jun Liu, Enhua Xiao, Changlian Tan, Yibin Xie, Jing An, Zishu Zhang, Zhanming Fan, Debiao Li
The objective of this study was to assess the relationship between imaging surrogates for diffuse fibrosis and myocardial dysfunction. Thirty-six New Zealand white rabbits were classified into two groups: a control group (n = 18) and an alloxan-induced diabetes mellitus (DM) group (n = 18). For all rabbits, conventional ultrasonography, two-dimensional speckle tracking, and cardiac magnetic resonance (CMR) T1 mapping were performed; all of the rabbits were then sacrificed for Masson's staining. The extracellular volume (ECV) was calculated from pre- and post-contrast T1 values and compared with myocardial function measured by echocardiography using Pearson's correlation...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314485/prognostic-implications-of-fasting-plasma-glucose-in-subjects-with-echocardiographic-abnormalities
#10
Manan Pareek, Muthiah Vaduganathan, Deepak L Bhatt, Margrét Leósdóttir, Michael H Olsen
AIMS: To examine whether baseline fasting plasma glucose (FPG) modifies the prognostic role of left ventricular (LV) mass, geometric pattern, and diastolic function, for prediction of cardiovascular morbidity and mortality. METHODS: Population-based cohort study comprising of 1047 men and 456 women with preserved ejection fraction, included between 2002 and 2006, who underwent echocardiography based on groups defined by FPG, measured prior to echocardiography. The clinical endpoint was the composite of cardiovascular events and all-cause mortality, assessed through national and local registries...
February 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28299608/dissipative-energy-loss-within-the-left-ventricle-detected-by-vector-flow-mapping-in-diabetic-patients-with-controlled-and-uncontrolled-blood-glucose-levels
#11
Chun-Mei Li, Wen-Juan Bai, Yan-Ting Liu, Hong Tang, Li Rao
Diabetes mellitus (DM) is related to increased risks of cardiovascular diseases, such as myocardial infarction, diabetic cardiomyopathy and secondary hypertension. Dissipative energy loss (EL) derived from vector flow mapping (VFM) is thought to reflect the efficiency of blood flow and has been deemed to be an index for the evaluation of left ventricular function. Our study aimed to investigate the value of dissipative EL in diabetic patients with controlled and uncontrolled blood glucose by VFM. Eighty-eight patients with DM and 58 age-matched healthy controls were recruited...
March 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28298172/potential-prognostic-biomarkers-of-cardiovascular-disease-in-fetal-macrosomia-the-impact-of-gestational-diabetes
#12
Despina D Briana, Κleopatra Germanou, Μaria Boutsikou, Theodora Boutsikou, Νikolaos Athanasopoulos, Αntonios Μarmarinos, Dimitrios Gourgiotis, Αriadne Malamitsi-Puchner
OBJECTIVE: Fetal macrosomia is associated with cardiac hypertrophy and increased cardiovascular risk. Cardiac biomarkers may play diagnostic/prognostic role in cardiovascular disease. We tested whether cardiac biomarkers are differentially expressed in cord blood samples of full-term singleton large-for-gestational-age (LGA), as compared to appropriate-for-gestational-age (AGA) pregnancies. METHODS: Cardiotrophin-1 (CT-1), Titin, pentraxin (PTX-3) and soluble CD36 (sCD36) concentrations were determined in 80 cord blood samples from a) LGA pregnancies due to maternal diabetes (n = 8), overweight/obese (n = 11), excessive weight gain (n = 7), without specific pathology (n = 14), b) AGA normal pregnancies (controls, n = 40)...
March 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28292297/subclinical-left-ventricular-diastolic-dysfunction-and-incident-type-2-diabetes-risk-the-korean-genome-and-epidemiology-study
#13
Juri Park, Jin-Seok Kim, Seong Hwan Kim, Sunwon Kim, Sang Yup Lim, Hong-Euy Lim, Goo-Yeong Cho, Ki-Chul Sung, Jang-Young Kim, Inkyung Baik, Kwang Kon Koh, Jung Bok Lee, Seung Ku Lee, Chol Shin
BACKGROUND: Subclinical left ventricular (LV) diastolic dysfunction in type 2 diabetes (T2D) is a common finding and represents an early sign of diabetic cardiomyopathy. However, the relationship between LV diastolic dysfunction and the incident T2D has not been previously studied. METHODS: A total of 1817 non-diabetic participants (mean age, 54 years; 48% men) from the Korean Genome and Epidemiology Study who were free of cardiovascular disease were studied. LV structure and function were assessed by conventional echocardiography and tissue Doppler imaging...
March 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28292262/low-adiponectin-is-associated-with-diastolic-dysfunction-in-women-a-cross-sectional-study-from-the-troms%C3%A3-study
#14
Jon V Norvik, Henrik Schirmer, Kirsti Ytrehus, Trond G Jenssen, Svetlana N Zykova, Anne E Eggen, Bjørn O Eriksen, Marit D Solbu
BACKGROUND: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. METHODS: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomial regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest...
March 14, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28289072/down-regulation-of-mir-15a-b-accelerates-fibrotic-remodelling-in-the-type%C3%A2-2-diabetic-human-and-mouse-heart
#15
Shruti Rawal, Pujika Emani Munasinghe, Prashanth Thevkar Nagesh, Jason Kar Sheng Lew, Gregory T Jones, Michael J A Williams, Philip Davis, Dick Bunton, Ivor F Galvin, Patrick Manning, Regis R Lamberts, Rajesh Katare
Aim: Myocardial fibrosis is a well-established cause of increased myocardial stiffness and subsequent diastolic dysfunction in the diabetic heart. The molecular regulators that drive the process of fibrotic events in the diabetic heart are still unknown. We determined the role of the microRNA (miR)-15 family in fibrotic remodelling of the diabetic heart.Methods and results: Right atrial appendage (RAA) and left ventricular (LV) biopsy tissues collected from diabetic and non-diabetic (ND) patients undergoing coronary artery bypass graft surgery showed significant down-regulation of miR-15a and -15b...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28287141/myricitrin-alleviates-oxidative-stress-induced-inflammation-and-apoptosis-and-protects-mice-against-diabetic-cardiomyopathy
#16
Bin Zhang, Qiang Shen, Yaping Chen, Ruile Pan, Shihuan Kuang, Guiyan Liu, Guibo Sun, Xiaobo Sun
Diabetic cardiomyopathy (DCM) has been increasingly considered as a main cause of heart failure and death in diabetic patients. At present, no effective treatment exists to prevent its development. In the present study, we describe the potential protective effects and mechanisms of myricitrin (Myr) on the cardiac function of streptozotosin-induced diabetic mice and on advanced glycation end products (AGEs)-induced H9c2 cardiomyocytes. In vitro experiments revealed that pretreatment with Myr significantly decreased AGEs-induced inflammatory cytokine expression, limited an increase in ROS levels, and reduced cell apoptosis, fibrosis, and hypertrophy in H9c2 cells...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270839/which-prognostic-factors-should-be-used-in-pulmonary-arterial-hypertension-in-elderly-patients
#17
Bahri Akdeniz, Ebru Ozpelit
In recent times, the prevalence of pulmonary arterial hypertension (PAH) is more commonly seen among elderly populations. The increased prevalence of hypertension, diabetes, obesity, arterial stiffness, as well as diastolic dysfunction, may cause endothelial dysfunction and affect pulmonary vasculature. Furthermore, older patients have certain differences in clinical characteristics and outcomes. In this article, the special characteristics of aging in PAH patients have been reviewed, while the risk predictors of elderly patients are also discussed...
January 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28270143/residential-distance-to-major-roadways-and-cardiac-structure-in-african-americans-cross-sectional-results-from-the-jackson-heart-study
#18
Anne M Weaver, Gregory A Wellenius, Wen-Chih Wu, DeMarc A Hickson, Masoor Kamalesh, Yi Wang
BACKGROUND: Heart failure (HF) is a significant source of morbidity and mortality among African Americans. Ambient air pollution, including from traffic, is associated with HF, but the mechanisms remain unknown. The objectives of this study were to estimate the cross-sectional associations between residential distance to major roadways with markers of cardiac structure: left ventricular (LV) mass index, LV end-diastolic diameter, LV end-systolic diameter, and LV hypertrophy among African Americans...
March 8, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28247566/natural-history-of-severe-aortic-stenosis-diastolic-wall-strain-as-a-novel-prognostic-marker
#19
Edinrin Obasare, Vikas Bhalla, Deepakraj Gajanana, Mary Rodriguez Ziccardi, Jose N Codolosa, Vincent M Figueredo, Dennis Lynn Morris, Gregg S Pressman
BACKGROUND AND AIM: Diastolic wall strain (DWS) has been proposed as a simple noninvasive measure of left ventricular (LV) stiffness. This study investigated DWS as a possible predictor of mortality in severe aortic stenosis (AS). METHODS: 138 patients with severe AS (indexed aortic valve area [AVA]<0.6 cm(2) /m(2) ) and normal ejection fraction (>55%) were included. 52 patients (38%) had aortic valve interventions or poor image quality (n=5) and were excluded leaving 86 in the study group (84±8 years, 70% female, 69% African American)...
March 1, 2017: Echocardiography
https://www.readbyqxmd.com/read/28224405/complications-of-acromegaly-cardiovascular-respiratory-and-metabolic-comorbidities
#20
REVIEW
Rosario Pivonello, Renata S Auriemma, Ludovica F S Grasso, Claudia Pivonello, Chiara Simeoli, Roberta Patalano, Mariano Galdiero, Annamaria Colao
Acromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction...
February 2017: Pituitary
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