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Diabetes diastolic dysfunction

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https://www.readbyqxmd.com/read/29338775/comparison-of-speckle-tracking-echocardiography-with-invasive-hemodynamics-for-the-detection-of-characteristic-cardiac-dysfunction-in-type-1-and-type-2-diabetic-rat-models
#1
Csaba Mátyás, Attila Kovács, Balázs Tamás Németh, Attila Oláh, Szilveszter Braun, Márton Tokodi, Bálint András Barta, Kálmán Benke, Mihály Ruppert, Bálint Károly Lakatos, Béla Merkely, Tamás Radovits
BACKGROUND: Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices of left ventricular (LV) pressure-volume (PV) analysis to detect cardiac dysfunction in rat models of type-1 (T1DM) and type-2 (T2DM) diabetes mellitus. METHODS: Rat models of T1DM (induced by 60 mg/kg streptozotocin, n = 8) and T2DM (32-week-old Zucker Diabetic Fatty rats, n = 7) and corresponding control animals (n = 5 and n = 8, respectively) were compared...
January 16, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29330646/potential-impact-of-sglt2-inhibitors-on-left-ventricular-diastolic-function-in-patients-with-diabetes-mellitus
#2
REVIEW
Hidekazu Tanaka, Ken-Ichi Hirata
The pathogenesis of diabetes mellitus (DM)-related cardiac dysfunction is thought to be multifactorial, and possibly a key factor for the development of heart failure with preserved ejection fraction (HFpEF) in patients with DM and preserved left ventricular (LV) ejection fraction. Currently, there is no effective treatment for HFpEF, which is presented as LV diastolic dysfunction. Furthermore, it is well known that, in addition to DM, hypertension and overweight/obesity are also important factors associated with HFpEF...
January 12, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29325553/sitagliptin-improved-glucose-assimilation-in-detriment-of-fatty-acid-utilization-in-experimental-type-ii-diabetes-role-of-glp-1-isoforms-in-glut4-receptor-trafficking
#3
E Ramírez, B Picatoste, A González-Bris, M Oteo, F Cruz, A Caro-Vadillo, J Egido, J Tuñón, M A Morcillo, Ó Lorenzo
BACKGROUND: The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improves glucose homeostasis but it could also trigger direct cardioprotective actions, including regulation of energy substrate utilization. METHODS: Type-II diabetic GK (Goto-Kakizaki), sitagliptin-treated GK (10 mg/kg/day) and wistar rats (n = 10, each) underwent echocardiographic evaluation, and positron emission tomography scanning for [18F]-2-fluoro-2-deoxy-D-glucose (18FDG)...
January 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29322879/puerarin-prevents-diabetic-cardiomyopathy-in-vivo-and-in-vitro-by-inhibition-of-inflammation
#4
Mao-Shan Yin, Yi-Chi Zhang, Shu-Hong Xu, Jing-Jing Liu, Xiao-Hui Sun, Chen Liang, Yan Wang, Jie Li, Fu-Wen Wang, Qing-Li Wang, Yan-Ling Mu
Diabetic cardiomyopathy (DCM) is one of the chief diabetes mellitus complications. Inflammation factors may be one reason for the damage from DM. The purpose of this research is to study the potential protective effects of puerarin on DM and the possible mechanisms of action related to NF-κB signal pathway. Following administration of puerarin to the disease model rat, several changes were observed including the changes of serum biochemical index, improved diastolic dysfunction, and enhanced endogenous antioxidant enzymes activities, further NF-κB signaling activation...
January 11, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29317451/duration-of-diabetes-and-prediabetes-during-adulthood-and-subclinical-atherosclerosis-and-cardiac-dysfunction-in-middle-age-the-cardia-study
#5
Jared P Reis, Norrina B Allen, Michael P Bancks, J Jeffrey Carr, Cora E Lewis, Joao A Lima, Jamal S Rana, Samuel S Gidding, Pamela J Schreiner
OBJECTIVE: To determine whether the duration of diabetes and duration of prediabetes estimated during a 25-year period in early adulthood are each independently associated with coronary artery calcified plaque (CAC) and abnormalities in left ventricular structure and function later in life. RESEARCH DESIGN AND METHODS: Participants were 3,628 white and black adults aged 18-30 years without diabetes or prediabetes at baseline (1985-1986) in the Coronary Artery Risk Development in Young Adults (CARDIA) Study...
January 9, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29311401/hepatic-cyst-compressing-the-right-atrial-and-ventricular-inflow-tract-an-uncommon-cardiac-complication
#6
Maulik Panchal, Ahmed Alansari, Marc Wallack, Ferdinand Visco, Susan Williams, Alexander M Sy
Commonly reported complications of hepatic cysts are spontaneous hemorrhage, rupture into the peritoneal cavity, infection and compression of the biliary tree however cardiac complications are not commonly reported. We are presenting a case of a large liver cyst presenting with right atrial and ventricular inflow tract impingement resulting in cardiac symptoms. A 68 year-old Hispanic female presented with one month of fatigue and shortness of breath after household work and walking less than one block, right upper quadrant pain and weight loss...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310998/coronary-artery-calcifications-and-diastolic-dysfunction-versus-visceral-fat-area-in-type-1-diabetes-viscera-study
#7
Christophe E M De Block, Bharati Shivalkar, Wouter Goovaerts, Tim Brits, Ken Carpentier, An Verrijken, Viviane Van Hoof, Paul M Parizel, Chris Vrints, Luc F Van Gaal
AIMS: Type 1 diabetic patients (T1DM) experience a higher cardiovascular disease and mortality risk than controls. We investigated whether visceral adipose tissue (VAT) contributes to coronary artery calcifications (CAC) and cardiac dysfunction in T1DM. METHODS: A cross-sectional study of 118 T1DM patients without a history of cardiovascular disease (men/women: 68/50, age 46±12years, HbA1c 7.6±0.9%, BMI 25.8±4.1kg/m2) was conducted. CAC and VAT were measured using a CT scan...
November 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29304136/effect-of-intensive-multifactorial-treatment-on-vascular-progenitor-cells-in-hypertensive-patients
#8
Charbel Maroun-Eid, Adriana Ortega-Hernández, Javier Modrego, María Abad-Cardiel, José Antonio García-Donaire, Leonardo Reinares, Nieves Martell-Claros, Dulcenombre Gómez-Garre
BACKGROUND: Most hypertensive patients, despite a proper control of their cardiovascular risk factors, have cardiovascular complications, evidencing the importance of controlling and/or reversing target-organ damage. In this sense, endothelial dysfunction has been associated with the presence of cardiovascular risk factors and related cardiovascular outcomes. Since hypertension often clusters with other risk factors such as dyslipemia, diabetes and obesity, in this study we have investigated the effect of intensive multifactorial treatment on circulating vascular progenitor cell levels on high-risk hypertensive patients...
2018: PloS One
https://www.readbyqxmd.com/read/29301532/body-mass-index-type-2-diabetes-and-left-ventricular-function
#9
EDITORIAL
Katrine Dina Musaeus, Manan Pareek
A recent study found that among individuals with a preserved left ventricular ejection fraction ≥ 55%, global longitudinal strain was significantly lower in overweight patients (i.e., body mass index ≥ 25 kg/m2) with, but not in those without, type 2 diabetes mellitus. These results contrast previous observations of body mass index as a significant predictor of incident diastolic dysfunction and increased left ventricular mass index among subjects without prevalent diabetes. We discuss potential explanations for the observed discrepancies and general difficulties associated with cardiovascular risk assessment based on body mass index and related metabolic factors...
January 4, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29289652/cellular-mechanisms-of-metabolic-syndrome-related-atrial-decompensation-in-a-rat-model-of-hfpef
#10
Felix Hohendanner, David Bode, Uwe Primessnig, Tim Guthof, Rafael Doerr, Sarah Jeuthe, Sophie Reimers, Kun Zhang, Doris Bach, Paulina Wakula, Burkert M Pieske, Frank R Heinzel
Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We postulate that atrial remodeling is associated with atrial dysfunction in vivo related to alterations in cardiomyocyte Calcium (Ca) signaling and remodeling. We examined atrial function in vivo and Ca transients (CaT) (Fluo4-AM, field stim) in atrial cardiomyocytes of ZSF-1 rats without (Ln; lean hypertensive) and with metabolic syndrome (Ob; obese, hypertensive, diabetic) and HFpEF...
December 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29285284/activation-of-the-ngf-trka-signaling-pathway-attenuates-diabetic-erectile-dysfunction
#11
Yi Hou, Linpei Jia, Ying Zhang, Wei Ji, Hai Li
Erectile dysfunction (ED) is a common complication of diabetes mellitus (DM). The exact role of the NGF/TrkA signaling pathway in the pathogenesis of diabetic ED is largely unknown. In the present study, we investigated the role of the NGF/TrkA signaling pathway in Sprague-Dawley rats with diabetic ED. Animals were divided into 2 groups: the normal group and the DM ED model group. The model group included the blank subgroup, the negative control (NC) subgroup, the TrkA subgroup and the TrkA + NGF subgroup. Erectile function, intracavernous pressure (ICP) and mean arterial pressure were measured respectively...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29246511/fetal-cardiac-function-in-maternal-diabetes-a%C3%A2-conventional-and-speckle-tracking-echocardiographic-study
#12
Joana O Miranda, Rui J Cerqueira, Carla Ramalho, José Carlos Areias, Tiago Henriques-Coelho
BACKGROUND: Intrauterine exposure to a diabetic environment is associated with adverse fetal myocardial remodeling. The aim of this study was to assess the biventricular systolic and diastolic function of fetuses exposed to maternal diabetes (MD) compared with control subjects, using a comprehensive cardiac functional assessment and exploring the role of speckle-tracking to assess myocardial deformation. The authors hypothesized that fetuses exposed to MD present signs of biventricular dysfunction, which can be detected by deformation analysis...
December 12, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29246363/cardiac-biomarkers-in-youth-with-type-2-diabetes-mellitus-results-from-the-today-study
#13
RANDOMIZED CONTROLLED TRIAL
Samuel S Gidding, Fida Bacha, Petter Bjornstad, Lorraine E Levitt Katz, Lynne L Levitsky, Jane Lynch, Jeanie B Tryggestad, Ruth S Weinstock, Laure El Ghormli, Joao A C Lima
OBJECTIVES: To examine cardiac biomarkers over time in youth-onset type 2 diabetes, and relate serum concentrations to cardiovascular disease risk factors, and left ventricular structure and function. STUDY DESIGN: TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) was a multicenter randomized trial of 3 treatments including 521 participants with type 2 diabetes, aged 10-17 years, and with 2-6 years of follow-up. Participants were 36% male, obese, and ethnically diverse...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29234934/early-detection-of-left-ventricular-diastolic-dysfunction-using-conventional-and-speckle-tracking-echocardiography-in-a-large-animal-model-of-metabolic-dysfunction
#14
Mark M P van den Dorpel, Ilkka Heinonen, Sanne M Snelder, Hendrik J Vos, Oana Sorop, Ron T van Domburg, Daphne Merkus, Dirk J Duncker, Bas M van Dalen
Left ventricular (LV) diastolic dysfunction is one of the important mechanisms responsible for symptoms in patients with heart failure. The aim of the current study was to identify parameters that may be used to detect early signs of LV diastolic dysfunction in diabetic pigs on a high fat diet, using conventional and speckle tracking echocardiography. The study population consisted of 16 healthy Göttingen minipigs and 18 minipigs with experimentally induced metabolic dysfunction. Echocardiography measurements were performed at baseline and 3-month follow-up...
December 12, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29212237/association-of-type-2-diabetes-mellitus-and-ratio-of-transmitral-e-wave-velocity-to-early-diastole-mitral-velocity-with-cardiovascular-events-in-chronic-kidney-disease
#15
Po-Chih Chen, Jiun-Chi Huang, Szu-Chia Chen, Pei-Yu Wu, Jia-Jung Lee, Yi-Wen Chiu, Jer-Ming Chang, Hung-Chun Chen, Yeou-Lih Huang
The association between DM and left ventricular diastolic dysfunction, assessed using the ratio of peak early transmitral filling wave velocity (E) to early diastolic velocity of mitral annulus (Ea), with cardiovascular (CV) outcomes in patients with chronic kidney disease (CKD) remains uncertain. This study included 356 CKD stage 3-5 patients underwent echocardiography. All patients were classified into four groups based on the presence of DM and E/Ea ≤ or > 9. CV events included CV death, hospitalization for heart failure, unstable angina or nonfatal myocardial infarction, sustained ventricular arrhythmia, transient ischemic attack, and stroke...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208861/etiology-of-early-renal-allograft-dysfunction-and-comparison-between-dysfunction-and-function-group-a-single-center-study
#16
K M Hadiuzzaman, S F Islam, M O Faroque, R M Hossain, M Munirunnessa, S I Selim, M Morshed
Over a period of two years thirty five renal allograft recipients & donors were evaluated to find out the aetiology of early renal allograft dysfunction, in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from March 2010 to February 2012. A comparison was made between dysfunction & functioning graft group. Mean age of recipients were (36.4±9.4) years, mean age of donors were (41.7±8.3) years, with a male and female ratio of 3:1. Fifty percent recipients showed one heliotype match, ninety percent recipients were anti CMV antibody IgG positive, few were anti CMV antibody IgM positive...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29205484/subclinical-left-ventricular-systolic-and-diastolic-dysfunction-in-type-1-diabetic-children-and-adolescents-with-good-metabolic-control
#17
Tamer Yoldaş, Utku Arman Örün, Elif Sagsak, Zehra Aycan, Özkan Kaya, Senem Özgür, Selmin Karademir
OBJECTIVE: Cardiac dysfunction is a well-known consequence of diabetes mellitus. This study was designed to assess whether type 1 diabetic children and adolescents with good metabolic control have early echocardiographic signs of subclinical left ventricular dysfunction and whether diabetes duration has any influence, using conventional and nonconventional echocardiographic tools. METHODS: A total of 100 patients with type 1 diabetes mellitus and 80 gender- and age-matched healthy controls were included...
December 3, 2017: Echocardiography
https://www.readbyqxmd.com/read/29204251/roles-and-mechanisms-of-herbal-medicine-for-diabetic-cardiomyopathy-current-status-and-perspective
#18
REVIEW
Jinfan Tian, Yingke Zhao, Yanfei Liu, Yue Liu, Keji Chen, Shuzheng Lyu
Diabetic cardiomyopathy is one of the major complications among patients with diabetes mellitus. Diabetic cardiomyopathy (DCM) is featured by left ventricular hypertrophy, myocardial fibrosis, and damaged left ventricular systolic and diastolic functions. The pathophysiological mechanisms include metabolic-altered substrate metabolism, dysfunction of microvascular, renin-angiotensin-aldosterone system (RAAS) activation, oxidative stress, cardiomyocyte apoptosis, mitochondrial dysfunction, and impaired Ca2+ handling...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29200863/endothelial-dysfunction-assessment-by-flow-mediated-dilation-in-a-high-altitude-population
#19
Walter S Calderón-Gerstein, Antonio López-Peña, Raúl Macha-Ramírez, Astrid Bruno-Huamán, Roxana Espejo-Ramos, Stephany Vílchez-Bravo, María Ramírez-Breña, Milagros Damián-Mucha, Adriana Matos-Mucha
Introduction: Endothelial function at high altitude has been measured only in populations that are genetically adapted to chronic hypoxia. The objective of this study was to evaluate endothelial dysfunction (ED) in a nongenetically adapted high-altitude population of the Andes mountains, in Huancayo, Peru (3,250 meters above sea level). Methods: Participants included 61 patients: 28 cases and 33 controls. The cases were subjects with hypertension, diabetes mellitus, obesity, or a history of stroke or coronary artery disease...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29192360/hyperglycemia-induced-cardiac-contractile-dysfunction-in-the-diabetic-heart
#20
REVIEW
Raphael M Singh, Tahreem Waqar, Frank C Howarth, Ernest Adeghate, Keshore Bidasee, Jaipaul Singh
The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in ryanodine receptor, reduced activity of the sarcoplasmic reticulum calcium pump (SERCA) and, along with reduced activity of the sodium-calcium exchanger (NCX) and alterations in myofilament, collectively cause a calcium imbalance within the diabetic cardiomyocytes...
December 1, 2017: Heart Failure Reviews
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