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Diabetes diastolic dysfunction

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https://www.readbyqxmd.com/read/27901470/sinomenine-prevents-the-development-of-cardiomyopathy-in-diabetic-rats-by-inhibiting-inflammatory-responses-and-blocking-activation-of-nf-%C3%AE%C2%BAb
#1
Cheng Jiang, Yun-Long Tong, Dan Zhang, Li-Zhi Liu, Ju-Fei Wang
Diabetic cardiomyopathy is a severe complication of diabetes mellitus (DM). The goal of current work was to study the effects of sinomenine on streptozotocin-induced cardiomyopathy in rats. DM in rats was induced by intraperitoneal injection of streptozotocin. Cardiac function was evaluated by measuring left ventricle end-diastolic diameter, left ventricle end-systolic diameter and ejection fraction. Cardiac inflammation was evaluated by the degree of infiltration of T lymphocytes and the levels of pro-inflammatory cytokines...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27894750/risk-factors-for-autonomic-and-somatic-nerve-dysfunction-in-different-stages-of-glucose-tolerance
#2
Rumyana Dimova, Tsvetalina Tankova, Velina Guergueltcheva, Ivailo Tournev, Nevena Chakarova, Greta Grozeva, Lilia Dakovska
AIM: The present study evaluates autonomic and somatic nerve function in different stages of glucose tolerance and its correlation with different cardio-metabolic parameters. MATERIAL AND METHODS: Four hundred seventy-eight subjects, mean age 49.3±13.7years and mean BMI 31.0±6.2kg/m2, divided according to glucose tolerance: 130 with normal glucose tolerance (NGT), 227 with prediabetes (125 with impaired fasting glucose (IFG) and 102 with isolated impaired glucose tolerance (iIGT)), and 121 with newly-diagnosed T2D (NDT2D), were enrolled...
November 6, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27894255/silent-diabetic-cardiomyopathy-in-everyday-practice-a-clinical-and-echocardiographic-study
#3
Brane Loncarevic, Danijela Trifunovic, Ivan Soldatovic, Bosiljka Vujisic-Tesic
BACKGROUND: Whether type 2 diabetes mellitus (DM) in the absence of hypertension (HTA) and coronary artery disease (CAD) affects left ventricular (LV) phenotype and function among asymptomatic DM patients that can be easily discovered in everyday practice, what is the clinical risk profile for diabetic cardiomyopathy and how HTA and CAD modulate LV structure and function above diabetic cardiomyopathy, are still incompletely answered questions. METHODS: In 210 DM patients (group I: 70 asymptomatic DM patients without HTA and CAD; group II: 70 DM patients with HTA and no CAD; group III: 70 DM patients with CAD and no HTA) and 80 healthy individuals, comprehensive echocardiography including speckle tracking strain and strain rate analysis, was done...
November 29, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27886160/left-ventricular-end-diastolic-volume-as-an-early-indicator-of-trastuzumab-related-cardiotoxicity-in-patients-with-her2-positive-breast-cancer-results-from-a-single-center-retrospective-study
#4
Corinna Bergamini, Flavia Torelli, Luca Ghiselli, Andrea Rossi, Laura Trevisani, Giulia Vinco, Stella Truong, Giovanni Benfari, Francesca LA Russa, Giorgio Golia, Annamaria Molino, Corrado Vassanelli
BACKGROUND: Adjuvant Trastuzumab therapy increases survival rates in patients with early HER2 positive breast cancer, although it can be potentially cardiotoxic. Aim of the study was to evaluate the prevalence of left ventricular (LV) systolic dysfunction; and the relationship between the presence of cardiovascular risk factors, cardiac therapy and/or echocardiographic parameters of systolic function at baseline and the development of cardiotoxicity in such patients. METHODS: 227 patients were retrospectively reviewed...
November 25, 2016: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/27884660/exenatide-improves-diastolic-function-and-attenuates-arterial-stiffness-but-does-not-alter-exercise-capacity-in-individuals-with-type-2-diabetes
#5
Rebecca L Scalzo, Kerrie L Moreau, Cemal Ozemek, Leah Herlache, Shawna McMillin, Sarah Gilligan, Amy G Huebschmann, Tim A Bauer, Jennifer Dorosz, Jane E B Reusch, Judith G Regensteiner
BACKGROUND: Exercise is recommended as a cornerstone of treatment for type 2 diabetes mellitus (T2DM), however, it is often poorly adopted by patients. Even in the absence of apparent cardiovascular disease, persons with T2DM have an impaired ability to carry out maximal and submaximal exercise and these impairments are correlated with cardiac and endothelial dysfunction. Glucagon-like pepetide-1 (GLP-1) augments endothelial and cardiac function in T2DM. We hypothesized that administration of a GLP-1 agonist (exenatide) would improve exercise capacity in T2DM...
October 7, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884237/diastolic-dysfunction-and-hypertension
#6
REVIEW
Wilson Nadruz, Amil M Shah, Scott D Solomon
Left ventricular (LV) diastolic dysfunction (LVDD) is characterized by alterations in LV diastolic filling, and is a strong predictor of cardiovascular events and heart failure. Hypertension is the most important risk factor for LVDD in the community and promotes LVDD through several mechanisms, including hemodynamic overload and myocardial ischemia. Associated factors such as age, ethnicity, dietary sodium, obesity, diabetes mellitus, and chronic kidney disease also contribute to LVDD in hypertensive individuals...
January 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/27874027/circulating-long-non-coding-rnas-as-biomarkers-of-left-ventricular-diastolic-function-and-remodelling-in-patients-with-well-controlled-type-2-diabetes
#7
D de Gonzalo-Calvo, F Kenneweg, C Bang, R Toro, R W van der Meer, L J Rijzewijk, J W Smit, H J Lamb, V Llorente-Cortes, T Thum
Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy age-matched volunteers were enrolled in the study. Left ventricular (LV) parameters were measured by magnetic resonance imaging. A panel of lncRNAs was quantified in serum by RT-qPCR. No differences in expression levels of lncRNAs were observed between type 2 diabetes patients and healthy volunteers...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27867429/correlation-between-diastolic-function-and-endothelial-function-in-patients-with-type-2-diabetes-and-hypertension
#8
Ricardo Bedirian, Mario Fritsch Neves, Wille Oigman, Ronaldo Altenburg Odebrecht Curi Gismondi, Cesar Romaro Pozzobon, Marcia Cristina Boaventura Ladeira, Marcia Bueno Castier
BACKGROUND: Endothelial dysfunction may be involved in the pathophysiology of cardiac abnormalities in patients with diabetes mellitus (DM). A correlation between endothelial dysfunction and diastolic dysfunction in patients with type 1 DM has been demonstrated, but this relationship has not been well investigated in type 2 DM. OBJECTIVE: Compare groups of patients with type 2 DM and hypertension with and without diastolic dysfunction using endothelial function indexes, and to assess whether correlations exist between the diastolic function and the endothelial function indexes...
2016: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/27862741/assessment-of-fetal-myocardial-performance-index-in-women-with-pregestational-and-gestational-diabetes-mellitus
#9
Cem Yasar Sanhal, Halil Korkut Daglar, Ozgur Kara, Dilek Uygur, Aykan Yucel
AIM: Fetal cardiac left ventricular function in pregnant women with pregestational or gestational diabetes mellitus was investigated by exploring fetal myocardial performance index (MPI) and E wave/A wave peak velocity (E/A) ratio. METHODS: Seventy pregnant women with either pregestational or gestational diabetes mellitus and with no other systemic or pregnancy related disorders were compared with 70 gestational age matched healthy controls by means of fetal left ventricular MPI and E/A ratio...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27862268/novel-protective-role-of-nuclear-melatonin-receptor-ror%C3%AE-in-diabetic-cardiomyopathy
#10
Yichao Zhao, Longwei Xu, Song Ding, Nan Lin, Qingqi Ji, Lingchen Gao, Yuanyuan Su, Jun Pu, Ben He
Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity and mortality in diabetics with few therapies. Moreover, anti-diabetic drugs reported inconsistent or even adverse cardiovascular effects, suggesting it is important to exploit novel therapeutic targets against diabetic cardiomyopathy. Here, we observed that the nuclear melatonin receptor, the retinoic acid-related orphan receptor α (RORα), was downregulated in diabetic hearts. By utilizing a mouse line with RORα disruption, we demonstrated that RORα deficiency led to significantly augmented diastolic dysfunction and cardiac remodeling induced by diabetes...
November 18, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27858918/global-longitudinal-strain-predicts-incident-atrial-fibrillation-and-stroke-occurrence-after-acute-myocardial-infarction
#11
Flemming Javier Olsen, Sune Pedersen, Jan Skov Jensen, Tor Biering-Sørensen
Patients with acute myocardial infarction are at increased risk of developing atrial fibrillation. We aimed to evaluate whether speckle tracking echocardiography improves risk stratification for atrial fibrillation in these patients.The study comprised of 373 patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention. Patients had an echocardiogram performed at a median of 2 days after their STEMI. The echocardiograms consisted of conventional measurements and myocardial strain analysis by speckle tracking from 3 apical projections...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27829587/pre-and-postoperative-predictors-of-long-term-prognosis-after-aortic-valve-replacement-for-severe-chronic-aortic-regurgitation
#12
Masashi Amano, Chisato Izumi, Sari Imamura, Naoaki Onishi, Jiro Sakamoto, Yodo Tamaki, Soichiro Enomoto, Makoto Miyake, Toshihiro Tamura, Hirokazu Kondo, Kazuaki Kaitani, Kazuo Yamanaka, Yoshihisa Nakagawa
BACKGROUND: There are few data on the long-term prognosis and chronological changes in left ventricular (LV) function after aortic valve replacement (AVR) in patients with severe chronic aortic regurgitation (AR) among the Japanese population.Methods and Results:We retrospectively investigated the long-term prognosis in 80 consecutive patients with severe chronic AR who underwent AVR. Additionally, 65 patients with follow-up echocardiography at 1 year after AVR were investigated to evaluate chronological changes in LV function...
November 9, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27822022/sex-specific-predictors-of-left-ventricular-diastolic-dysfunction-in-untreated-hypertension
#13
Joanna Jaroch, Olga Vriz, Zbigniew Bociąga, Caterina Driussi, Maria Łoboz-Rudnicka, Barbara Rzyczkowska, Krystyna Łoboz-Grudzień
BACKGROUND: Little is known about the sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors. We hypothesized that arterial stiffness (AS) may play a different role in the etiology of LV DD in hypertensive men and postmenopausal women, acting independently from other established predictors of this condition, such as age, obesity, diabetes mellitus, LV remodeling, and systolic function. OBJECTIVES: The aim of the study was to analyze the sex-specific differences in AS and other predictors of LV DD in men and postmenopausal women with untreated hypertension (HTN)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27818785/clinical-characteristics-of-asymptomatic-left-ventricular-diastolic-dysfunction-and-its-association-with-self-rated-health-and-n-terminal-b-type-natriuretic-peptide-a-cross-sectional-study
#14
Nasser S Ahmadi, Louise Bennet, Charlotte A Larsson, Susanne Andersson, Jörgen Månsson, Ulf Lindblad
AIMS: Left ventricular hypertrophy, obesity, hypertension, and N-terminal B-type natriuretic peptide (Nt-proBNP) predict left ventricular diastolic dysfunction with preserved systolic function (DD-PSF). Self-rated health (SRH) is shown to be associated with chronic diseases, but the association of SRH with DD-PSF is unclear. In light of the clinical implications of DD-PSF, the following goals are of considerable importance: (1) to determine the role of SRH in patients with DD-PSF in the general population and (2) to study the association between Nt-proBNP and DD-PSF...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27815962/the-effects-of-type-1-diabetes-mellitus-on-cardiac-functions-in-children-evaluation-by-conventional-and-tissue-doppler-echocardiography
#15
Osman Ozdemir, Adem Yasin Koksoy, Ayse Derya Bulus, Nesibe Andiran, Elif Yagli
BACKGROUND: Several studies have pointed out the existence of cardiac dysfunction in patients with type 1 diabetes mellitus (DM) even in the absence of ischemic, valvular, or hypertensive heart disease. The present study evaluated cardiac dysfunction and the relationship between severity of disease and degree of cardiac dysfunction in children with type 1 DM. METHODS: In this prospective study, 31 patients with type 1 DM and 33 sex- and age-matched healthy children were evaluated with conventional echocardiography and tissue Doppler echocardiography (TDE)...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27815373/inhibiting-insulin-mediated-%C3%AE-2ar-activation-prevents-diabetes-associated-cardiac-dysfunction
#16
Qingtong Wang, Yongming Liu, Qin Fu, Bing Xu, Yuan Zhang, Sungjin Kim, Ruensern Tan, Federica Barbagallo, Toni M West, Ethan J Anderson, Wei Wei, E Dale Abel, Yang K Xiang
BACKGROUND: -Type-2 diabetes and obesity independently increases the risk of heart failure via incompletely understood mechanisms. We propose that hyperinsulinemia might promote adverse consequences in hearts of subjects with type-2 diabetes and obesity. METHODS: -High fat diet feeding was used to induce obesity and diabetes in wild type mice or mice lacking β 2-adrenergic receptor (β2AR) or β -arrestin2. Wild type mice fed with high fat diet were treated with β -blocker carvedilol or G-protein receptor kinase 2 (GRK2) inhibitor...
November 4, 2016: Circulation
https://www.readbyqxmd.com/read/27810791/the-protective-role-of-liquiritin-in-high-fructose-induced-myocardial-fibrosis-via-inhibiting-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathway
#17
Yuan Zhang, Lei Zhang, Yi Zhang, Jin-Jin Xu, Li-Li Sun, Shuang-Zhan Li
Diabetic cardiomyopathy has been known as an important complication of diabetes and characterized by persistent diastolic dysfunction, resulting in myocardial fibrosis, which is associated inflammatory response and oxidative stress. Liquiritin is a major constituent of Glycyrrhiza Radix, possessing various pharmacological activities and exhibiting various positive biological effects, including anti-cancer, anti-oxidative and neuroprotective effects. Here, we investigated the anti-inflammatory properties and protective effects of lquiritin in high fructose-induced mice and cardiomyocytes to clarify the potential mechanism...
October 31, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27805564/coronary-artery-calcification-in-ckd-5d-%C3%A2-patients-is-tied-to-adverse-cardiac-function-%C3%A2-and-increased-mortality%C3%A2
#18
Paul Anaya, Gustav A Blomquist, Daniel L Davenport, Marie-Claude Monier-Faugere, Vincent L Sorrell, Hartmut H Malluche
BACKGROUND: Coronary artery calcification (CAC) is common in patients with chronic kidney disease on hemodialysis (CKD-5D) and is an important predictor of mortality. However, cardiac functional links between CAC and mortality have not been well established. This study tested the hypothesis that CAC increases mortality by adversely affecting cardiac function. METHODS: Patients were recruited from 37 regional dialysis centers. 2-D and Doppler echocardiographic analyses were performed, and CAC was measured using 64-slice computed tomography...
November 2, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27774267/the-clinical-significance-of-plasma-neopterin-in-heart-failure-with-preserved-left-ventricular-ejection-fraction
#19
Eiichiro Yamamoto, Yoshihiro Hirata, Takanori Tokitsu, Hiroaki Kusaka, Noriaki Tabata, Kenichi Tsujita, Megumi Yamamuro, Koichi Kaikita, Hiroshi Watanabe, Seiji Hokimoto, Toru Maruyama, Hisao Ogawa
AIMS: Although inflammation plays an important role in the pathogenesis of heart failure (HF), the precise pathophysiological role of inflammation in HF with preserved left ventricular ejection fraction (HFpEF) still remains unclear. Hence, we examined the clinical significance of plasma neopterin, an inflammatory biomarker, in HFpEF patients. METHODS AND RESULTS: In the present study, we recruited consecutive HFpEF patients hospitalized in Kumamoto University Hospital, and further measured plasma neopterin by high-performance liquid chromatography and serum derivatives of reactive oxidative metabolites (DROM), a new biomarker of reactive oxygen species...
March 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27762513/etiology-and-left-ventricular-functions-in-left-bundle-branch-block-a-prospective-observational-study
#20
Rajeev Bhardwaj
PURPOSE OF STUDY: Left bundle branch (LBBB) is common ECG finding. Common causes of LBBB are coronary artery disease (CAD), hypertension and dilated cardiomyopathy (DCM). Purpose of the study was to find out the etiology and left ventricular function in patients coming to a territory care hospital. MATERIAL AND METHODS: All consecutive patients coming to our hospital as indoor or outdoor patients with ECG suggestive of LBBB were studied. The detail history and examination was done...
September 2016: Journal of the Association of Physicians of India
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