Nicholas Goulet, Emily J Tetzlaff, James J McCormick, Kelli E King, Kristina-Marie T Janetos, Ronald J Sigal, Pierre Boulay, Glen P Kenny
Type 2 diabetes (T2D) is associated with worsening age-related impairments in heat loss, causing higher core temperature during exercise. We evaluated whether these thermoregulatory impairments occur with altered serum protein responses to heat stress by measuring cytoprotection, inflammation, and tissue damage biomarkers in middle-aged-to-older men (50-74 years) with (n=16) and without (n=14) T2D following exercise in 40°C. There were no changes in irisin, klotho, HSP70, sCD14, TNF-α, and IL-6, whereas NGAL (+539 pg/mL, p=0...
March 20, 2024: Applied Physiology Nutrition and Metabolism