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https://www.readbyqxmd.com/read/28750471/modulation-of-the-activated-protein-c-pathway-in-severe-haemophilia-a-patients-the-effects-of-thrombomodulin-and-a%C3%A2-factor-v-stabilizing-fab
#1
D F Brophy, E J Martin, B M Mohammed, J C Barrett, J G Kuhn, M E Nolte, B Wiinberg, H L Holmberg, J Lund, R Salbo, E K Waters
INTRODUCTION: The thrombomodulin (TM)/activated protein C (APC) system is a key regulator of haemostasis, limiting amplification and propagation of the formed blood clot to the injury site. Dampening APC's inhibition of factor V (FV) and factor VIII (FVIII) may be a future strategy in developing next-generation therapeutic targets for haemophilia treatment. AIMS: To determine ex vivo the respective concentration-dependent effects of TM and a FV-stabilizing Fab on the APC regulatory pathway in severe FVIII-deficient blood and plasma...
July 27, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28750435/-cell-transplantation-in-age-related-macular-degeneration
#2
Bernd Kirchhof
Robert Machemer offers a surgical approach to age-related macular degeneration with his retinal rotation. There is already considerable experimental and clinical knowledge available in Europe and the US on transplantation techniques for age-related macular degeneration. On average, initial visual acuity can be preserved. When photodynamic therapy was standard for exudative AMD, transplantation was superior. Photodynamic therapy could not stop, but was instead able to slow down visual loss. Currently, VEGF-blocker therapy has priority, because the visual acuity can be improved...
July 27, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28750242/rotational-diffusion-of-magnetic-nanoparticles-in-protein-solutions
#3
Ana C Bohórquez, Chuncheng Yang, Donald Bejleri, Carlos Rinaldi
The rotational diffusion of polyethylene glycol coated magnetic nanoparticles in serum albumin solutions was investigated in a range spanning 0mgmL(-1) to 200mgmL(-1). Rotational diffusivities were determined from dynamic magnetic susceptibility measurements, which provide a non-optical means to probe rotation of nanoparticles in small volume samples. Experimental rotational diffusivities were compared to those estimated using the Stokes-Einstein relation and macroscopic measurements of the viscosity of the protein solutions...
July 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28750168/molecular-dynamics-of-cyclodextrins-in-water-solutions-from-nmr-deuterium-relaxation-implications-for-cyclodextrin-aggregation
#4
Artur José Monteiro Valente, Rui Albuquerque Carvalho, Dina Murtinho, Olle Soderman
The aggregation of the most common natural cyclodextrins (α-, β- and γ-) in aqueous solutions is addressed by studying the CD-CD interactions using deuterium relaxation rates for deuterium labelled CDs. Relaxation times (T1) and its corresponding relaxation rates (R1=1/T1) provide information about the rotational correlation times of CDs and serve as a proxy for solute-solute interactions. Measured T1's for α-, β-, and γ-CD at the lowest CD concentrations were in agreement with predictions of a hydrodynamic model for toroids, in particular with regard to the dependence of T1 on CD size...
July 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28749751/the-relationship-between-segmental-kinematics-and-ball-spin-in-type-2-cricket-spin-bowling
#5
Aaron J Beach, René E D Ferdinands, Peter J Sinclair
The techniques of spin bowling in cricket have been largely formulated from the collective intuitions of past players. A standard model of bowling technique has been generally prescribed for both off-spin and leg-spin bowlers, but there has been no biomechanics research to validate this approach. This study measured 20 Type-2 off-spin and 15 Type-2 leg-spin bowlers using a 3D Cortex motion analysis system. Correlation coefficients between segmental kinematic variables and spin rate in the off-spin and leg-spin bowlers revealed that off-spin bowling was associated with an earlier movement time of the thorax, whereas leg-spin bowling was associated with a greater magnitude and earlier movement time of pelvis rotation, as well as a greater magnitude of pelvis-shoulder separation movement...
July 27, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28749694/how-do-methyl-groups-enhance-the-triplet-chemiexcitation-yield-of-dioxetane
#6
Morgane Vacher, Pooria Farahani, Alessio Valentini, Luis Manuel Frutos, Hans O Karlsson, Ignacio Fernández Galván, Roland Lindh
Chemiluminescence is the emission of light as a result of a non-adiabatic chemical reaction. The present work is concerned with understanding the yield of chemiluminescence, in particular how it dramatically increases upon methylation of 1,2-dioxetane. Both ground-state and non-adiabatic dynamics (including singlet excited states) of the decomposition reaction of various methyl-substituted dioxetanes have been simulated. Methyl-substitution leads to a significant increase in the dissociation half-life. The rotation around the O-C-C-O dihedral angle is slowed down and thus, the molecular system stays longer in the "entropic trap" region...
July 27, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28749674/reaction-ensemble-monte-carlo-simulation-of-xylene-isomerization-in-bulk-phases-and-under-confinement
#7
Ryan G Mullen, Edward J Maginn
The original reaction move for the reaction ensemble Monte Carlo (RxMC) method is adapted to align both the position and orientation of inserted product molecules and deleted reactant molecules. The accuracy and efficiency of this move is demonstrated for xylene isomerization in vapor, liquid, and supercritical phases. Classical RxMC requires the ideal gas free energy of reaction ∆G(ideal)rxn as an input. We compare three methods for computing ∆G(ideal)rxn: using tabulated enthalpies and entropies of formation, using the harmonic oscillator and rigid rotor approximations, and using QM/MM alchemical transformation combined with multistate Bennett acceptance ratio...
July 27, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28749641/factors-affecting-mental-patients%C3%A2-behaviors-and-attitudes-regarding-smoking
#8
Michael Kourakos, Maria Saridi, Theodora Kafkia, Maria Rekleiti, Kyriakos Souliotis, Hero Brokalaki, Evmorfia Koukia
Background: Patients with mental health problems are in high risk to develop addiction, since smoking incidence is three times higher than that of the general population. The aim of the study was to investigate the factors affecting mental health patients’ smoking habits. Methods: The sample of study were 356 patients out of 403 initially approached, with 142 hospitalized in hospital facilities and 214 in community settings. The «Smoking in psychiatric hospitals” and General Health Questionnaire (GHQ-28) questionnaires were used...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749440/optimization-of-detection-accuracy-of-closed-loop-optical-voltage-sensors-based-on-pockels-effect
#9
Wei Deng, Hui Li, Chunxi Zhang, Pengjie Wang
The influence of optical parameters on the performance of closed-loop optical voltage sensors (OVSs) based on Pockels effect is analyzed and a control algorithm is proposed to suppress the nonlinearity caused by the unideal parameters of optical devices for optimizing the detection precision of OVSs. First, a quantified model of the feedback phase demonstrates how the optical parameters of optical devices (including light source, polarizer, 45° fusion point, Faraday rotator and half-wave plate) result in the nonlinearity of closed-loop OVSs...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749032/hip-internal-rotation-in-cerebral-palsy-does-femoral-derotation-osteotomy-influence-abductor-insufficiency
#10
Bruno Dohin
No abstract text is available yet for this article.
July 27, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28748933/spontaneous-breaking-of-rotational-symmetry-in-copper-oxide-superconductors
#11
J Wu, A T Bollinger, X He, I Božović
The origin of high-temperature superconductivity in copper oxides and the nature of the 'normal' state above the critical temperature are widely debated. In underdoped copper oxides, this normal state hosts a pseudogap and other anomalous features; and in the overdoped materials, the standard Bardeen-Cooper-Schrieffer description fails, challenging the idea that the normal state is a simple Fermi liquid. To investigate these questions, we have studied the behaviour of single-crystal La2-xSrxCuO4 films through which an electrical current is being passed...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28748594/spanish-validation-of-the-pas-add-checklist-questionnaire-for-people-with-intellectual-disabilities-for-spanish-population
#12
A Martorell, M C González, P Gutiérrez, F Rincón, M H Núñez-Polo
BACKGROUND: The Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD) is an international reference tool for the diagnosis and assessment of mental health problems and behavioural disorders among people with intellectual disabilities. Although the original PAS-ADD instrument has been validated in the Spanish language, the shorter PAS-ADD Checklist has yet not been validated. The aim of this study is to validate the PAS-ADD Checklist for the Spanish population...
July 26, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28748419/can-we-train-military-surgeons-in-a-civilian-trauma-center
#13
H Uchino, V Y Kong, G V Oosthuizen, J L Bruce, W Bekker, G L Laing, D L Clarke
INTRODUCTION: The objective of this study was to review the trauma workload and operative exposure in a major South African trauma center and provide a comparison with contemporary experience from major military conflict. MATERIALS AND METHODS: All patients admitted to the PMTS following trauma were identified from the HEMR. Basic demographic data including mechanism of injury and body region injured were reviewed. All operative procedures were categorized. The total operative volume was compared with those available from contemporary literature documenting experience from military conflict in Afghanistan...
July 26, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28748362/case-study-failure-of-superior-capsular-reconstruction-using-dermal-allograft
#14
J Zerr, J D McDermott, N M Beckmann, R K Fullick, A Chhabra
Superior capsular reconstruction (SCR) is a novel technique for treating irreparable rotator cuff tears in younger patients in whom a reverse total shoulder arthroplasty is not the optimal treatment choice. This case study describes a middle-aged male with a recurrent, massive, irreparable rotator cuff tear treated with SCR that subsequently failed at the glenoid attachment. The patient underwent successful arthroscopic revision of the SCR. The case illustrates the MRI and arthroscopic correlations of the failed dermal allograft reconstruction, which to our knowledge has not been previously shown in the radiology literature...
July 26, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28748326/the-factor-structure-of-the-spiritual-well-being-scale-in-veterans-experienced-chemical-weapon-exposure
#15
Hamid Sharif Nia, Saeed Pahlevan Sharif, Christopher Boyle, Ameneh Yaghoobzadeh, Bahram Tahmasbi, G Hussein Rassool, Mozhgan Taebei, Mohammad Ali Soleimani
This study aimed to determine the factor structure of the spiritual well-being among a sample of the Iranian veterans. In this methodological research, 211 male veterans of Iran-Iraq warfare completed the Paloutzian and Ellison spiritual well-being scale. Maximum likelihood (ML) with oblique rotation was used to assess domain structure of the spiritual well-being. The construct validity of the scale was assessed using confirmatory factor analysis (CFA), convergent validity, and discriminant validity. Reliability was evaluated with Cronbach's alpha, Theta (θ), and McDonald Omega (Ω) coefficients, intra-class correlation coefficient (ICC), and construct reliability (CR)...
July 26, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28748293/racial-disparities-in-outcomes-of-operatively-treated-lower-extremity-fractures
#16
Adam Driesman, Nina Fisher, Sanjit R Konda, Christian A Pean, Philipp Leucht, Kenneth A Egol
PURPOSE: Whether racial differences are associated with function in the long term following surgical repair of lower extremity fractures has not been investigated. The purpose of this study is to compare how race affects function at 3, 6 and 12 months post-surgery following certain lower extremity fractures. METHODS: Four hundred and eighteen patients treated operatively for a lower extremity fracture (199 tibial plateau, 39 tibial shaft, and 180 rotational ankle fractures) were prospectively followed for 1 year...
July 26, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28748291/predictors-of-outcomes-after-arthroscopic-transosseous-equivalent-rotator-cuff-repair-in-155-cases-a-propensity-score-weighted-analysis-of-knotted-and-knotless-self-reinforcing-repair-techniques-at-a-minimum-of-2%C3%A2-years
#17
Peter J Millett, Chris Espinoza, Marilee P Horan, Charles P Ho, Ryan J Warth, Grant J Dornan, J Christoph Katthagen
PURPOSE: To evaluate the outcomes of two commonly used transosseous-equivalent (TOE) arthroscopic rotator cuff repair (RCR) techniques for full-thickness supraspinatus tendon tears (FTST) using a robust multi-predictor model. METHODS: 155 shoulders in 151 patients (109 men, 42 women; mean age 59 ± 10 years) who underwent arthroscopic RCR of FTST, using either a knotted suture bridging (KSB) or a knotless tape bridging (KTB) TOE technique were included. ASES and SF-12 PCS scores assessed at a minimum of 2 years postoperatively were modeled using propensity score weighting in a multiple linear regression model...
July 26, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28748015/evaluation-of-problem-based-learning-curriculum-implementation-in-a-clerkship-rotation-of-a-newly-established-african-medical-training-institution-lessons-from-the-university-of-botswana
#18
Stephane Tshitenge Tshitenge, Chiratidzo Ellen Ndhlovu, Radiance Ogundipe
INTRODUCTION: Problem-based Learning (PBL) curricula, like all curricula, require systematic evaluation as there is a risk of implementing a dysfunctional PBL curriculum. The study intended to evaluate the PBL curriculum delivery from the perspective of the clerkship students at the University of Botswana-Faculty of Medicine. METHODS: A cross-sectional study was conducted among clerkship students in Family Medicine, Paediatrics, Internal Medicine and Surgery. During a 4-week period, each respondent completed weekly a questionnaire based survey tool...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28748005/-detection-of-complete-common-mesentery-on-ct-scan-for-perforation-in-acute-appendicitis
#19
Traore Abdoulaye Ababacar, Mvumbi Kutubisa Franck, Ly Seydou, Alaoui Lamrany Youssef, Boubbou Meryem, Maaroufi Maaroufi, Alami Badreeddine
Complete common mesentery is a rare abnormality in midgut rotation. Its detection is exceptional during adulthood because, during this period, is very often asymptomatic and therefore not diagnosed. Complete common mesentery may be discovered incidentally in patients with ectopic appendicular syndrome, as in our case study. We here report the case of a 42-year old patient presenting with acute clinico-biological pelvic inflammatory disorder. CT scan allowed the diagnosis of complete common mesentery associated with acute appendicitis...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28747987/experimental-determination-of-three-dimensional-cervical-joint-mobility-in-the-avian-neck
#20
Robert E Kambic, Andrew A Biewener, Stephanie E Pierce
BACKGROUND: Birds have highly mobile necks, but neither the details of how they realize complex poses nor the evolution of this complex musculoskeletal system is well-understood. Most previous work on avian neck function has focused on dorsoventral flexion, with few studies quantifying lateroflexion or axial rotation. Such data are critical for understanding joint function, as musculoskeletal movements incorporate motion around multiple degrees of freedom simultaneously. Here we use biplanar X-rays on wild turkeys to quantify three-dimensional cervical joint range of motion in an avian neck to determine patterns of mobility along the cranial-caudal axis...
2017: Frontiers in Zoology
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