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S Karki, D Tuyenbayev, S Kandhasamy, B P Abbott, T D Abbott, E H Anders, J Berliner, J Betzwieser, C Cahillane, L Canete, C Conley, H P Daveloza, N De Lillo, J R Gleason, E Goetz, K Izumi, J S Kissel, G Mendell, V Quetschke, M Rodruck, S Sachdev, T Sadecki, P B Schwinberg, A Sottile, M Wade, A J Weinstein, M West, R L Savage
The two interferometers of the Laser Interferometry Gravitational-wave Observatory (LIGO) recently detected gravitational waves from the mergers of binary black hole systems. Accurate calibration of the output of these detectors was crucial for the observation of these events and the extraction of parameters of the sources. The principal tools used to calibrate the responses of the second-generation (Advanced) LIGO detectors to gravitational waves are systems based on radiation pressure and referred to as photon calibrators...
November 2016: Review of Scientific Instruments
Janne Kaltiainen, Jukka Lipponen, Brian C Holtz
This study examines two fundamental concerns in the context of organizational change: employees' perceptions of merger process justice and cognitive trust in the top management team. Our main purpose is to better understand the nature of reciprocal relations between these important constructs through a significant change event. Previous research, building mainly on social exchange theory, has framed trust as a consequence of justice perceptions. More recently, scholars have suggested that this view may be overly simplistic and that trust-related cognitions may also represent an important antecedent of justice perceptions...
November 28, 2016: Journal of Applied Psychology
Vuk Mandic, Simeon Bird, Ilias Cholis
Recent Advanced LIGO detections of binary black hole mergers have prompted multiple studies investigating the possibility that the heavy GW150914 binary system was of primordial origin, and hence could be evidence for dark matter in the form of black holes. We compute the stochastic background arising from the incoherent superposition of such primordial binary black hole systems in the Universe and compare it to the similar background spectrum due to binary black hole systems of stellar origin. We investigate the possibility of detecting this background with future gravitational-wave detectors, and conclude that constraining the dark matter component in the form of black holes using stochastic gravitational-wave background measurements will be very challenging...
November 11, 2016: Physical Review Letters
Orel Shlomi, Eyal Preter, Dexin Ba, Yosef London, Yair Antman, Avi Zadok
Brillouin optical correlation-domain analysis (B-OCDA) allows for distributed measurements of strain and temperature with sub-cm resolution. Time-multiplexing techniques have previously extended B-OCDA to the monitoring of many km of fiber and two million resolution points. Thus far, however, the number of scans of correlation peaks positions, necessary to cover the fiber under test, was restricted to the order of 100 or more. In this work we report a B-OCDA protocol that is able to address an entire fiber using only 11 pairs of position scans per choice of frequency...
November 14, 2016: Optics Express
Vladimir Jelnin, Chad Kliger, Fabio Zucchetta, Carlos E Ruiz
With increasing utilization of cardiac computed tomographic angiography (CTA) and widespread adoption of fusion imaging technology allowing the merger of pre-procedural CTA with fluoroscopy, the ability of CTA to guide structural heart interventions has evolved significantly. It has opened new possibilities in mitral valve (MV) interventions with improved pre-procedural planning and intra-procedural guidance. Given the lack of fluoroscopic landmarks of the mitral apparatus and continued growth of native MV device technologies, the value of CTA will continue to develop...
January 2016: Interventional cardiology clinics
David L Eisenberg, V C Leslie
To be healthy, support their families, and be productive members of their communities, women must have access to comprehensive reproductive health services including treatment of miscarriage and ectopic pregnancy and access to abortion, sterilization, and other contraceptive methods. However, in the United States, hospitals and legislative bodies are erecting barriers and limiting access to these basic health care services. These barriers are caused by factors such as hospital mergers (specifically those that are religiously affiliated); federal, state, and local legislation; hospital policies; and business-related decisions are threatening reproductive health care...
November 4, 2016: American Journal of Obstetrics and Gynecology
Andrew D Goldsmith, Francisco Varela
The large number of biopharmaceutical mergers and acquisitions (M&A) that occurred over the past decade has generated questions about whether the industry is consolidating around too-few players, negatively impacting both the number of medicines developed and overall innovation. However, closer examination of the level of biopharmaceutical consolidation shows that the industry was more fragmented in 2015 than it was in 2003 by prescription drug sales. The trend towards increasing fragmentation is also observed across noncommercial and independent metrics over the same time period...
November 2, 2016: Drug Discovery Today
Y Z Wang, D S Huang, J T Shi, J M Ma, B Li, X L Xu, H M Hu, Y Zhou, H L Gu
Objective: To observe the treatment and prognosis of choroid invasion of retinoblastoma (RB) in children. Method: A total of 149 children who had been diagnosed with unilateral RB and received enucleation disclosing tumor invasion to choroid from January 2006 to December 2013 in Beijing Tongren Hospital were recruited in this study. Choroid involvement was classified as massive choroid invasion and focal choroid invasion. Massive choroid invasion was defined as a maximum diameter of invasive tumor focus of 3 mm or more in diameter that might reach the scleral tissue...
November 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Gurpur Rakesh D Prabhu, Pawel L Urban
Gasometric assays involve measurements of the amounts of gases that are released during physical or chemical processes. The available instrumentation for gasometric analysis is generally difficult to use, and requires large sample volumes. In some cases, toxic materials (mercury) are involved in the analysis process. Here we propose a microscale gasometric assay using mineral oil as matrix. Microliter-volume (~ 2.5 μL) aqueous droplets, containing sample and reagent and/or catalyst, are introduced to the oil matrix, and merged...
October 31, 2016: Analytical Chemistry
Dawei Zhang, Qi Pan, Chen Tan, Bin Zhu, Xianhong Ge, Yujiao Shao, Zaiyun Li
The young allotetraploid Brassica napus (2n = 38, AACC) is one of models to study genomic responses to allopolyploidization. The extraction of AA component from natural B. napus and then restitution of progenitor B. rapa should provide a unique opportunity to reveal the genome interplay for gene expressions during the evolution. Herein, B. napus hybrids (2n = 19, AC) between the extracted and extant B. rapa (2n = 20, AA) and the same B. oleracea genotype (2n = 18, CC) were studied by RNA-seq and compared with natural B...
2016: Frontiers in Plant Science
Ettore J Rastelli, Ngoc T Truong, Don M Coltart
A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through the merger of iminium ion catalysis and transition-metal catalysis such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine catalyst rather than a chiral nonracemic phosphine as is typical of conventional asymmetric hydroacylation methods.
October 21, 2016: Organic Letters
Kimitake Hayasaki, Abraham Loeb
Galaxy mergers produce supermassive black hole binaries, which emit gravitational waves prior to their coalescence. We perform three-dimensional hydrodynamic simulations to study the tidal disruption of stars by such a binary in the final centuries of its life. We find that the gas stream of the stellar debris moves chaotically in the binary potential and forms accretion disks around both black holes. The accretion light curve is modulated over the binary orbital period owing to relativistic beaming. This periodic signal allows to detect the decay of the binary orbit due to gravitational wave emission by observing two tidal disruption events that are separated by more than a decade...
October 21, 2016: Scientific Reports
Rabea Seyboldt, Dimitri Merger, Fabian Coupette, Miriam Siebenbürger, Matthias Ballauff, Manfred Wilhelm, Matthias Fuchs
The leading nonlinear stress response in a periodically strained concentrated colloidal dispersion is studied experimentally and by theory. A thermosensitive microgel dispersion serves as well-characterized glass-forming model, where the stress response at the first higher harmonic frequency (3ω for strain at frequency ω) is investigated in the limit of small amplitude. The intrinsic nonlinearity at the third harmonic exhibits a scaling behavior which has a maximum in an intermediate frequency window and diverges when approaching the glass transition...
October 18, 2016: Soft Matter
Michael Martin, Heiner Fangerau, Axel Karenberg
BACKGROUND: This paper summarizes the current state of research into the role of German neurology during National Socialism (NS) on the basis of extensive secondary literature and key original sources. SUMMARY: As early as 1933, many neurologists and neuroscientists who had been branded as 'non-Aryan' and/or politically persecuted had to leave Germany, were driven to suicide or killed in concentration camps. Two years later, the regulatory merger with the Psychiatrists' Association caused the cautious attempts of the institutionally hampered discipline for autonomy to end in complete failure...
2016: European Neurology
Patrick J Moon, Shengkang Yin, Rylan J Lundgren
We report decarboxylative carbonyl α-arylation by coupling arylboron nucleophiles with malonic acid derivatives. This process is enabled by the merger of aerobic oxidative Cu-catalysis with decarboxylative enolate interception reminiscent of malonyl-CoA reactivity in polyketide biosynthesis. This method allows for the synthesis of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible with existing α-arylation reactivity paradigms. The utility of the reaction is demonstrated in drug intermediate synthesis and late-stage functionalization...
October 13, 2016: Journal of the American Chemical Society
Paulo S Pinheiro, Sébastien Houy, Jakob B Sørensen
The molecular mechanisms for calcium-triggered membrane fusion have long been sought for, and detailed models now exist that account for at least some of the functions of the many proteins involved in the process. Key players in the fusion reaction are a group of proteins that, upon binding to calcium, trigger the merger of cargo-filled vesicles with the plasma membrane. Low-affinity, fast-kinetics calcium sensors of the synaptotagmin family - especially synaptotagmin-1 and synaptotagmin-2 - are the main calcium sensors for fast exocytosis triggering in many cell types...
October 12, 2016: Journal of Neurochemistry
K S Mikkonen, D Merger, P Kilpeläinen, L Murtomäki, U S Schmidt, M Wilhelm
Materials manufacturing industries seek efficient, economic, and sustainable compounds for stabilizing dispersed systems such as emulsions. In this study, novel, abundant biobased hydrocolloids spruce galactoglucomannans (GGM) and birch glucuronoxylans (GX) were obtained from a forestry biorefining process and characterized as versatile stabilizers of rapeseed oil-in-water emulsions. For the first time, GGM and GX isolated by pressurized hot water extraction (PHWE) of spruce and birch saw meal, respectively, were studied in emulsions...
September 27, 2016: Soft Matter
Qinbo Qin, Zhengfa Lai, Liu Cao, Qiong Xiao, YuDe Wang, Shaojun Liu
To better understand genomic changes in the early generations after polyploidisation, we examined the chromosomal consequences of genomic merger in allotetraploid hybrids (4 nF1) (AABB, 4n = 148) of Carassius auratus red var. (RCC) (AA, 2n = 100) (♀) × Megalobrama amblycephala (BSB) (BB, 2n = 48) (♂). Complete loss of the paternal 5S rDNA sequence and the expected number of maternal chromosomal loci were found in 4 nF1, suggesting directional genomic changes occurred in the first generations after polyploidisation...
October 5, 2016: Scientific Reports
(no author information available yet)
Estimates of future growth in the oncology market, a predicted increase of 11% per year in sales, and the need to expand drug-development pipelines to sustain profits have been driving up the value of corporate mergers, such as Pfizer's purchase of Medivation for $14 billion.
September 30, 2016: Cancer Discovery
E Brad Thompson
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
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