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https://www.readbyqxmd.com/read/28336175/the-academic-industrial-complex-navigating-the-translational-and-cultural-divide
#1
REVIEW
Stephen Freedman, Kevin Mullane
In general, the fruits of academic discoveries can only be realized through joint efforts with industry. However, the poor reproducibility of much academic research has damaged credibility and jeopardized translational efforts that could benefit patients. Meanwhile, journals are rife with articles bemoaning the limited productivity and increasing costs of the biopharmaceutical industry and its resultant predilection for mergers and reorganizations while decreasing internal research efforts. The ensuing disarray and uncertainty has created tremendous opportunities for academia and industry to form even closer ties, and to embrace new operational and financial models to their joint benefit...
March 20, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28319032/binary-neutron-star-mergers-a-review-of-einstein-s-richest-laboratory
#2
Luca Baiotti, Luciano Rezzolla
The merger of binary neutron-stars systems combines in a single process: extreme gravity, copious emission of gravitational waves, complex microphysics, and electromagnetic processes that can lead to astrophysical signatures observable at the largest redshifts. We review here the recent progress in understanding what could be considered Einstein's richest laboratory, highlighting in particular the numerous significant advances of the last decade. Although special attention is paid to the status of models, techniques, and results for fully general-relativistic dynamical simulations, a review is also offered on initial data and advanced simulations with approximate treatments of gravity...
March 20, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28315813/the-case-for-applying-tissue-engineering-methodologies-to-instruct-human-organoid-morphogenesis
#3
REVIEW
Carlos R Marti-Figueroa, Randolph S Ashton
Three-dimensional organoids derived from human pluripotent stem cell (hPSC) derivatives have become widely used in vitro models for studying development and disease. Their ability to recapitulate facets of normal human development during in vitro morphogenesis produces tissue structures with unprecedented biomimicry. Current organoid derivation protocols primarily rely on spontaneous morphogenesis processes to occur within 3-D spherical cell aggregates with minimal to no exogenous control. This yields organoids containing microscale regions of biomimetic tissues, but at the macroscale (i...
March 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28303717/visible-light-promoted-c-h-arylation-by-mergering-palladium-catalysis-with-organic-photoredox-catalysis
#4
Jian Jiang, Wen-Man Zhang, Jian-Jun Dai, Jun Xu, Hua-Jian Xu
The use of a dual palladium/organic photoredox catalytic system enables the directed arylation of arenes with aryldiazonium salts with broad substrate scope at room temperature under mild reaction conditions. This study thus serves as not only an alternative route for the biaryl motifs but also a new example for the application of organic photoredox catalyst.
March 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28299333/an-alternative-treatment-strategy-for-complicated-chronic-wounds-negative-pressure-therapy-over-mesh-skin-graft
#5
Michele Maruccia, Maria G Onesti, Valentina Sorvillo, Antonio Albano, Luca A Dessy, Bruno Carlesimo, Mauro Tarallo, Marco Marcasciano, Giuseppe Giudice, Emanuele Cigna, Diego Ribuffo
Extensive skin defect represents a real problem and major challenge in plastic and reconstructive surgery. On one hand, skin grafts offer a practical method to deal with skin defects despite their unsuitability for several complicated wounds. On the other hand, negative pressure wound therapy (NPWT), applied before skin grafting, promotes granulation tissue growth. The aim of the study is to evaluate the improvement in wound healing given by the merger of these two different approaches. We treated 23 patients for large wounds of multiple factors...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28287543/modified-drop-tower-impact-tests-for-american-football-helmets
#6
G Alston Rush, R Prabhu, Gus A Rush, Lakiesha N Williams, M F Horstemeyer
A modified National Operating Committee on Standards for Athletic Equipment (NOCSAE) test method for American football helmet drop impact test standards is presented that would provide better assessment of a helmet's on-field impact performance by including a faceguard on the helmet. In this study, a merger of faceguard and helmet test standards is proposed. The need for a more robust systematic approach to football helmet testing procedures is emphasized by comparing representative results of the Head Injury Criterion (HIC), Severity Index (SI), and peak acceleration values for different helmets at different helmet locations under modified NOCSAE standard drop tower tests...
February 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28283663/ligo-and-the-opening-of-a-unique-observational-window-on-the-universe
#7
Vassiliki Kalogera, Albert Lazzarini
A unique window on the universe opened on September 14, 2015, with direct detection of gravitational waves by the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) detectors. This event culminated a half-century effort around the globe to develop terrestrial detectors of adequate sensitivity to achieve this goal. It also happened appropriately only a few months before the centennial of Einstein's final paper introducing the general theory of relativity. This detection provided the surprising discovery of a coalescing pair of "heavy" black holes (more massive than [Formula: see text] M[Formula: see text]) leading to the formation of a spinning [Formula: see text]62 solar mass black hole...
March 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28277723/employees-responses-to-an-organizational-merger-intraindividual-change-in-organizational-identification-attachment-and-turnover
#8
Wookje Sung, Meredith L Woehler, Jesse M Fagan, Travis J Grosser, Theresa M Floyd, Giuseppe Joe Labianca
The authors used pre-post merger data from 599 employees experiencing a major corporate merger to compare 3 conceptual models based on the logic of social identity theory (SIT) and exchange theory to explain employees' merger responses. At issue is how perceived change in employees' own jobs and roles (i.e., personal valence) and perceived change in their organization's status and merger appropriateness (i.e., organizational valence) affect their changing organizational identification, attachment attitudes, and voluntary turnover...
March 9, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28276075/change-commitment-in-low-status-merger-partners-the-role-of-information-processing-relative-ingroup-prototypicality-and-merger-patterns
#9
Miriam Rosa, Eithne Kavanagh, Pavel Kounov, Sywlia Jarosz, Sven Waldzus, Elizabeth C Collins, Steffen Giessner
Merger announcements cause stress among employees, often leading to low change commitment, especially among employees from the lower-status merger partner. Such stress influences how deeply employees process merger-relevant information. Previous research examined how merger patterns that preserve versus change status differences impact merger support, but did not address how employees' information processing may influence this relationship. The current research addresses this gap through a scenario experiment, focusing on the low-status merger partner...
March 9, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28264758/merging-outpatient-addiction-and-opioid-maintenance-programs-during-a-disaster-lessons-from-hurricane-sandy
#10
Vishal K Gupta, Helena Hansen, Sonia Mendoza, Xinlin Linda Chen, Ronnie G Swift
OBJECTIVE: After Hurricane Sandy flooded Bellevue Hospital in New York City, its opiate maintenance patients were displaced and Bellevue's outpatient program was temporarily merged with the program at Metropolitan Hospital for continuation of care. The merger forced Metropolitan to accommodate a program twice as large as its own and required special staff coordination and adjustments in clinical care. METHODS: Physicians, clinicians, and administrators from both institutions participated in interviews regarding the merger...
March 7, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28263615/modeling-of-manganese-atom-and-dimer-isolated-in-solid-rare-gases-structure-stability-and-effect-on-spin-coupling
#11
Nadezhda N Kleshchina, Kseniia A Korchagina, Dmitry S Bezrukov, Alexei A Buchachenko
Structures and energies of the trapping sites of manganese atom and dimer in solid Ar, Kr, and Xe are investigated within the classical model, which balances local distortion and long-range crystal order of the host and provides a means to estimate the relative site stabilities. The model is implemented with the additive pairwise potential field based on the ab initio and best empirical interatomic potential functions. In agreement with experiment, Mn single substitution (SS) and tetrahedral vacancy (TV) occupation are identified as stable for Ar and Kr, whereas the SS site is only found for Xe...
March 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28256860/emergent-structures-in-an-active-polar-fluid-dynamics-of-shape-scattering-and-merger
#12
Kabir Husain, Madan Rao
Spatially localized defect structures emerge spontaneously in a hydrodynamic description of an active polar fluid comprising polar "actin" filaments and "myosin" motor proteins that (un)bind to filaments and exert active contractile stresses. These emergent defect structures are characterized by distinct textures and can be either static or mobile-we derive effective equations of motion for these "extended particles" and analyze their shape, kinetics, interactions, and scattering. Depending on the impact parameter and propulsion speed, these active defects undergo elastic scattering or merger...
February 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28256088/prevalence-of-elevated-liver-enzymes-in-adults-with-type-1-diabetes-a-multicenter-analysis-of-the-german-austrian-dpv-database
#13
Marietta Stadler, Esther Bollow, Maria Fritsch, Wolfgang Kerner, Ingrid Schuetz-Fuhrmann, Dietmar Krakow, Sigrun Merger, Michaela Riedl, Peter Jehle, Reinhard W Holl
AIMS: To assess the prevalence of elevated liver enzymes in adults with type 1 diabetes mellitus (T1DM) in routine clinical care and the association with cardiovascular risk profile in the Diabetes-Prospective-Documentation (DPV) network in Germany and Austria. METHODS: This cross sectional observational study from the DPV registry includes data from 45519 adults with T1DM at 478 centers up to 9/2016. Liver enzyme measurements were available in 9226 (29%) patients at 270 centers and were analyzed for increased alanine aminotransferase (ALT; men > 50 U/l, women: >35U/l) and/or aspartate aminotransferase (AST; men >50 U/l, women >35U/l) and/or gamma-glutamyltransferase (GGT; men >60U/l, women > 40 U/l)...
March 2, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28253966/in-vitro-reconstitution-of-autophagosome-lysosome-fusion
#14
J Diao, L Li, Y Lai, Q Zhong
SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) proteins are a highly regulated class of membrane proteins lying in the center of membrane fusion. In conjunction with accessory proteins, SNAREs drive efficient merger of two distinct lipid bilayers into one interconnected structure. This chapter describes our fluorescence resonance energy transfer (FRET)-based proteoliposome fusion assays for the roles of various SNARE proteins, accessory proteins, and effects of different lipid compositions on membrane fusion involved in autophagy...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28236720/do-hospital-mergers-reduce-costs
#15
Matt Schmitt
Proponents of hospital consolidation claim that mergers lead to significant cost savings, but there is little systematic evidence backing these claims. For a large sample of hospital mergers between 2000 and 2010, I estimate difference-in-differences models that compare cost trends at acquired hospitals to cost trends at hospitals whose ownership did not change. I find evidence of economically and statistically significant cost reductions at acquired hospitals. On average, acquired hospitals realize cost savings between 4 and 7 percent in the years following the acquisition...
March 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28220717/merger-acquisition-and-capital-expenditure-in-health-care
#16
Wenjing Ouyang, Peter E Hilsenrath
Investment, especially through merger and acquisition (M&A), is a leading topic of concern among health care managers. In addition, the implications of this activity for organization and market concentration are of great interest to policy makers. Using a sample of 2256 firm-year observations in the health care industry during the period from 1985 to 2011, this article provides novel evidence that managers learn from financial markets in making capital expenditure (CAPEX) and M&A investment decisions. Within the industry, managers in the Drugs subsector are most likely to do so, whereas managers in the Medical Equipment and Supplies are least likely to do so...
January 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28214046/productivity-growth-case-mix-and-optimal-size-of-hospitals-a-16-year-study-of-the-norwegian-hospital-sector
#17
Kjartan Sarheim Anthun, Sverre Andreas Campbell Kittelsen, Jon Magnussen
BACKGROUND AND OBJECTIVES: This paper analyses productivity growth in the Norwegian hospital sector over a period of 16 years, 1999-2014. This period was characterized by a large ownership reform with subsequent hospital reorganizations and mergers. We describe how technological change, technical productivity, scale efficiency and the estimated optimal size of hospitals have evolved during this period. MATERIAL AND METHODS: Hospital admissions were grouped into diagnosis-related groups using a fixed-grouper logic...
January 30, 2017: Health Policy
https://www.readbyqxmd.com/read/28190508/navigating-the-clinical-trial-pathway-conception-design-execution-and-results-dissemination
#18
John S Sampalis, Joanne Watson, Stella Boukas, Marianna Boukas, Natalie Harvey, Sanjay Machado, Michel Bordeleau, Emmanouil Rampakakis
Dr Sampalis is founder, Chief Executive Officer, and Chief Scientific Officer of JSS Medical Research Inc, founded in 1997. He is a tenured professor of Surgery and Epidemiology & Biostatistics of McGill University, the University of Montreal and University of Laval. Recognized as a leading clinical epidemiologist and one of the top trauma researchers in Canada, he possesses extensive expertise in health services research, clinical trials, and offers services as a Research and Epidemiological Consultant for numerous pharmaceutical companies, hospitals and government organizations and agencies...
March 2017: Surgery
https://www.readbyqxmd.com/read/28188812/epigenetics-in-cancer-fundamentals-and-beyond
#19
REVIEW
Subhankar Biswas, C Mallikarjuna Rao
Activation of oncogenes or the deactivation of tumor suppressor genes has long been established as the fundamental mechanism leading towards carcinogenesis. Although this age old axiom is vastly accurate, thorough study over the last 15years has given us unprecedented information on the involvement of epigenetic in cancer. Various biochemical pathways that are essential towards tumorigenesis are regulated by the epigenetic phenomenons like remodeling of nucleosome by histone modifications, DNA methylation and miRNA mediated targeting of various genes...
February 8, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28167725/little-evidence-exists-to-support-the-expectation-that-providers-would-consolidate-to-enter-new-payment-models
#20
Hannah T Neprash, Michael E Chernew, J Michael McWilliams
Provider consolidation has been associated with higher health care prices and spending. The prevailing wisdom is that payment reform will accelerate consolidation, especially between physicians and hospitals and among physician groups, as providers position themselves to bear financial risk for the full continuum of patient care. Drawing on data from a number of sources from 2008 onward, we examined the relationship between Medicare's accountable care organization (ACO) programs and provider consolidation. We found that consolidation was under way in the period 2008-10, before the Affordable Care Act (ACA) established the ACO programs...
February 1, 2017: Health Affairs
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