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https://www.readbyqxmd.com/read/28432523/hypothesis-free-analyses-from-a-large-psoriatic-arthritis-cohort-support-merger-to-consolidated-peripheral-arthritis-definition-without-subtyping
#1
Daniel Stekhoven, Almut Scherer, Michael J Nissen, Véronique Grobéty, Nikhil Yawalkar, Peter M Villiger, Burkhard Möller
Current ClASsification criteria for Psoriatic ARthritis classification criteria for psoriatic arthritis (PsA) provide a preliminary definition of inflammatory articular disease. This study aimed to further characterize PsA peripheral arthritis using purely data-driven approaches for the affected joint distribution pattern. PsA patients from the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) database were clustered according to similarities in 66 swollen and in 68 tender joints. Clusters were compared in terms of other disease characteristics and studied for coincidence with traditional PsA subtypes, stability over time and treatment response upon first tumour necrosis factor alpha (TNF-α) therapy...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28425692/antitrust-law-hospital-mergers-third-circuit-clarifies-geographic-market-definition-and-raises-bar-for-efficiencies-defense
#2
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Harvard Law Review
https://www.readbyqxmd.com/read/28423282/good-riddance-to-big-insurance-mergers
#3
Leemore S Dafny
Eighteen months after four of the five largest U.S. health insurers announced multibillion-dollar merger deals, federal judges, siding with the Department of Justice (DOJ), have issued preliminary injunctions halting the two transactions. These decisions will cost the insurers: they spent over $2..
April 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28418185/cu-pd-synergistic-dual-catalysis-asymmetric-%C3%AE-allylation-of-an-%C3%AE-cf3-amide
#4
Akira Saito, Naoya Kumagai, Masakatsu Shibasaki
Despite the burgeoning demand for fluorine-containing chemical entities, the construction of CF3 -containing stereogenic centers has remained elusive. Herein, we report the strategic merger of Cu(I) /base-catalyzed enolization of an α-CF3 amide and Pd(0) -catalyzed allylic alkylation in an enantioselective manner to deliver chiral building blocks bearing a stereogenic carbon center connected to a CF3 , an amide carbonyl, and a manipulable allylic group. The phosphine complexes of Cu(I) and Pd(0) engage in distinct catalytic roles without ligand scrambling to render the dual catalysis operative to achieve asymmetric α-allylation of the amide...
April 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28409933/benzene-c-h-etherification-via-photocatalytic-hydrogen-evolution-cross-coupling-reaction
#5
Yi-Wen Zheng, Pan Ye, Bin Chen, Qing-Yuan Meng, Ke Feng, Wenguang Wang, Li-Zhu Wu, Chen-Ho Tung
Aryl ethers can be constructed from the direct coupling between the benzene C-H bond and the alcohol O-H bond with the evolution of hydrogen via the synergistic merger of photocatalysis and cobalt catalysis. Utilizing the dual catalyst system consisting of 3-cyano-1-methylquinolinum photocatalyst and cobaloxime, intermolecular etherification of arenes with various alcohols and intramolecular alkoxylation of 3-phenylpropanols with formation of chromanes are accomplished. These reactions proceed at remarkably mild conditions, and the sole byproduct is equivalent hydrogen gas...
April 14, 2017: Organic Letters
https://www.readbyqxmd.com/read/28408922/a-novel-histogram-region-merging-based-multithreshold-segmentation-algorithm-for-mr-brain-images
#6
Siyan Liu, Xuanjing Shen, Yuncong Feng, Haipeng Chen
Multithreshold segmentation algorithm is time-consuming, and the time complexity will increase exponentially with the increase of thresholds. In order to reduce the time complexity, a novel multithreshold segmentation algorithm is proposed in this paper. First, all gray levels are used as thresholds, so the histogram of the original image is divided into 256 small regions, and each region corresponds to one gray level. Then, two adjacent regions are merged in each iteration by a new designed scheme, and a threshold is removed each time...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28408315/the-corr-hypothesis-for-genes-in-organelles
#7
John F Allen
Chloroplasts and mitochondria perform energy transduction in photosynthesis and respiration. These processes can be described in physico-chemical terms with no obvious requirement for co-located genetic systems, separated from those of the rest of the cell. Accordingly, biochemists once tended to regard endosymbiosis as untestable evolutionary speculation. Lynn Sagan's seminal 1967 paper "On the Origin of Mitosing Cells" outlined the evolution of eukaryotic cells by endosymbiosis of prokaryotes. The endosymbiont hypothesis is consistent with presence of DNA in chloroplasts and mitochondria, but does not assign it a function...
April 10, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28407809/merger-of-two-dispatch-centres-does-it-improve-quality-and-patient-safety
#8
Alexandre Moser, Annette Mettler, Vincent Fuchs, Walter Hanhart, Claude-François Robert, Vincent Della Santa, Fabrice Dami
BACKGROUND: Dispatch centres (DCs) are considered an essential but expensive component of many highly developed healthcare systems. The number of DCs in a country, region, or state is usually based on local history and often related to highly decentralised healthcare systems. Today, current technology (Global Positioning System or Internet access) abolishes the need for closeness between DCs and the population. Switzerland went from 22 DCs in 2006 to 17 today. This study describes from a quality and patient safety point of view the merger of two DCs...
April 13, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28399031/the-advance-care-planning-readiness-scale-development-and-validation-of-a-measure-of-willingness-to-discuss-and-acceptance-of-end-of-life-care-in-gynecologic-cancer-patients
#9
Alaina J Brown, Megan Johnson Shen, Diana Urbauer, Jolyn Taylor, Patricia A Parker, Cindy Carmack, Lauren Prescott, Carly Rosemore, Elizabeth Kolawole, Charlotte Sun, Lois Ramondetta, Diane C Bodurka
OBJECTIVE: The objective of this article was to develop and validate a scale that assesses the readiness of gynecologic oncology patients to engage in advance care planning. METHODS: The Advance Care Planning Readiness Scale (ACPRS) was validated across 3 independent samples of gynecologic oncology patients. In step I, patients underwent cognitive interviewing to determine if the scale items were comprehensible and applicable to patients. Based on this, modifications to the scale (addition, removal, and merger of items) were completed...
April 8, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28379657/cross-market-mergers-in-healthcare-adapting-antitrust-regulation-to-address-a-growing-concern
#10
Thaddeus J Lopatka
No abstract text is available yet for this article.
April 2017: Cornell Law Review
https://www.readbyqxmd.com/read/28378739/formation-of-the-first-three-gravitational-wave-observations-through-isolated-binary-evolution
#11
Simon Stevenson, Alejandro Vigna-Gómez, Ilya Mandel, Jim W Barrett, Coenraad J Neijssel, David Perkins, Selma E de Mink
During its first four months of taking data, Advanced LIGO has detected gravitational waves from two binary black hole mergers, GW150914 and GW151226, along with the statistically less significant binary black hole merger candidate LVT151012. Here we use the rapid binary population synthesis code COMPAS to show that all three events can be explained by a single evolutionary channel-classical isolated binary evolution via mass transfer including a common envelope phase. We show all three events could have formed in low-metallicity environments (Z=0...
April 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28355255/efficiency-and-optimal-size-of-hospitals-results-of-a-systematic-search
#12
Monica Giancotti, Annamaria Guglielmo, Marianna Mauro
BACKGROUND: National Health Systems managers have been subject in recent years to considerable pressure to increase concentration and allow mergers. This pressure has been justified by a belief that larger hospitals lead to lower average costs and better clinical outcomes through the exploitation of economies of scale. In this context, the opportunity to measure scale efficiency is crucial to address the question of optimal productive size and to manage a fair allocation of resources...
2017: PloS One
https://www.readbyqxmd.com/read/28342561/a-strategic-document-as-a-tool-for-implementing-change-lessons-from-the-merger-creating-the-south-east-health-region-in-norway
#13
Tarald Rohde, Hans Torvatn
In 2007, the Norwegian Parliament decided to merge the two largest health regions in the country: the South and East Health Regions became the South-East Health Region (SEHR). In its resolution, the Parliament formulated strong expectations for the merger: these included more effective hospital services in the Oslo metropolitan area, freeing personnel to work in other parts of the country, and making treatment of patients more coherent. The Parliamentary resolution provided no specific instructions regarding how this should be achieved...
March 6, 2017: Health Policy
https://www.readbyqxmd.com/read/28336175/the-academic-industrial-complex-navigating-the-translational-and-cultural-divide
#14
REVIEW
Stephen Freedman, Kevin Mullane
In general, the fruits of academic discoveries can only be realized through joint efforts with industry. However, the poor reproducibility of much academic research has damaged credibility and jeopardized translational efforts that could benefit patients. Meanwhile, journals are rife with articles bemoaning the limited productivity and increasing costs of the biopharmaceutical industry and its resultant predilection for mergers and reorganizations while decreasing internal research efforts. The ensuing disarray and uncertainty has created tremendous opportunities for academia and industry to form even closer ties, and to embrace new operational and financial models to their joint benefit...
March 20, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28319032/binary-neutron-star-mergers-a-review-of-einstein-s-richest-laboratory
#15
Luca Baiotti, Luciano Rezzolla
The merger of binary neutron-stars systems combines in a single process: extreme gravity, copious emission of gravitational waves, complex microphysics, and electromagnetic processes that can lead to astrophysical signatures observable at the largest redshifts. We review here the recent progress in understanding what could be considered Einstein's richest laboratory, highlighting in particular the numerous significant advances of the last decade. Although special attention is paid to the status of models, techniques, and results for fully general-relativistic dynamical simulations, a review is also offered on initial data and advanced simulations with approximate treatments of gravity...
March 20, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28315813/the-case-for-applying-tissue-engineering-methodologies-to-instruct-human-organoid-morphogenesis
#16
REVIEW
Carlos R Marti-Figueroa, Randolph S Ashton
Three-dimensional organoids derived from human pluripotent stem cell (hPSC) derivatives have become widely used in vitro models for studying development and disease. Their ability to recapitulate facets of normal human development during in vitro morphogenesis produces tissue structures with unprecedented biomimicry. Current organoid derivation protocols primarily rely on spontaneous morphogenesis processes to occur within 3-D spherical cell aggregates with minimal to no exogenous control. This yields organoids containing microscale regions of biomimetic tissues, but at the macroscale (i...
March 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28303717/visible-light-promoted-c-h-arylation-by-merging-palladium-catalysis-with-organic-photoredox-catalysis
#17
Jian Jiang, Wen-Man Zhang, Jian-Jun Dai, Jun Xu, Hua-Jian Xu
The use of a dual palladium/organic photoredox catalytic system enables the directed arylation of arenes with aryldiazonium salts with a broad substrate scope at room temperature under mild reaction conditions. This study thus serves as not only an alternative route for the biaryl motifs but also a new example for the application of an organic photoredox catalyst.
March 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28299333/an-alternative-treatment-strategy-for-complicated-chronic-wounds-negative-pressure-therapy-over-mesh-skin-graft
#18
COMPARATIVE STUDY
Michele Maruccia, Maria G Onesti, Valentina Sorvillo, Antonio Albano, Luca A Dessy, Bruno Carlesimo, Mauro Tarallo, Marco Marcasciano, Giuseppe Giudice, Emanuele Cigna, Diego Ribuffo
Extensive skin defect represents a real problem and major challenge in plastic and reconstructive surgery. On one hand, skin grafts offer a practical method to deal with skin defects despite their unsuitability for several complicated wounds. On the other hand, negative pressure wound therapy (NPWT), applied before skin grafting, promotes granulation tissue growth. The aim of the study is to evaluate the improvement in wound healing given by the merger of these two different approaches. We treated 23 patients for large wounds of multiple factors...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28287543/modified-drop-tower-impact-tests-for-american-football-helmets
#19
G Alston Rush, R Prabhu, Gus A Rush, Lakiesha N Williams, M F Horstemeyer
A modified National Operating Committee on Standards for Athletic Equipment (NOCSAE) test method for American football helmet drop impact test standards is presented that would provide better assessment of a helmet's on-field impact performance by including a faceguard on the helmet. In this study, a merger of faceguard and helmet test standards is proposed. The need for a more robust systematic approach to football helmet testing procedures is emphasized by comparing representative results of the Head Injury Criterion (HIC), Severity Index (SI), and peak acceleration values for different helmets at different helmet locations under modified NOCSAE standard drop tower tests...
February 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28283663/ligo-and-the-opening-of-a-unique-observational-window-on-the-universe
#20
Vassiliki Kalogera, Albert Lazzarini
A unique window on the universe opened on September 14, 2015, with direct detection of gravitational waves by the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) detectors. This event culminated a half-century effort around the globe to develop terrestrial detectors of adequate sensitivity to achieve this goal. It also happened appropriately only a few months before the centennial of Einstein's final paper introducing the general theory of relativity. This detection provided the surprising discovery of a coalescing pair of "heavy" black holes (more massive than [Formula: see text] M[Formula: see text]) leading to the formation of a spinning [Formula: see text]62 solar mass black hole...
March 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
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