Read by QxMD icon Read


Ettore J Rastelli, Ngoc T Truong, Don M Coltart
A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through the merger of iminium ion catalysis and transition-metal catalysis such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine catalyst rather than a chiral nonracemic phosphine as is typical of conventional asymmetric hydroacylation methods.
October 21, 2016: Organic Letters
Kimitake Hayasaki, Abraham Loeb
Galaxy mergers produce supermassive black hole binaries, which emit gravitational waves prior to their coalescence. We perform three-dimensional hydrodynamic simulations to study the tidal disruption of stars by such a binary in the final centuries of its life. We find that the gas stream of the stellar debris moves chaotically in the binary potential and forms accretion disks around both black holes. The accretion light curve is modulated over the binary orbital period owing to relativistic beaming. This periodic signal allows to detect the decay of the binary orbit due to gravitational wave emission by observing two tidal disruption events that are separated by more than a decade...
October 21, 2016: Scientific Reports
Rabea Seyboldt, Dimitri Merger, Fabian Coupette, Miriam Siebenbürger, Matthias Ballauff, Manfred Wilhelm, Matthias Fuchs
The leading nonlinear stress response in a periodically strained concentrated colloidal dispersion is studied experimentally and by theory. A thermosensitive microgel dispersion serves as well-characterized glass-forming model, where the stress response at the first higher harmonic frequency (3ω for strain at frequency ω) is investigated in the limit of small amplitude. The intrinsic nonlinearity at the third harmonic exhibits a scaling behavior which has a maximum in an intermediate frequency window and diverges when approaching the glass transition...
October 18, 2016: Soft Matter
Michael Martin, Heiner Fangerau, Axel Karenberg
BACKGROUND: This paper summarizes the current state of research into the role of German neurology during National Socialism (NS) on the basis of extensive secondary literature and key original sources. SUMMARY: As early as 1933, many neurologists and neuroscientists who had been branded as 'non-Aryan' and/or politically persecuted had to leave Germany, were driven to suicide or killed in concentration camps. Two years later, the regulatory merger with the Psychiatrists' Association caused the cautious attempts of the institutionally hampered discipline for autonomy to end in complete failure...
October 16, 2016: European Neurology
Patrick J Moon, Shengkang Yin, Rylan J Lundgren
We report decarboxylative carbonyl α-arylation by coupling arylboron nucleophiles with malonic acid derivatives. This process is enabled by the merger of aerobic oxidative Cu-catalysis with decarboxylative enolate interception reminiscent of malonyl-CoA reactivity in polyketide biosynthesis. This method allows for the synthesis of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible with existing α-arylation reactivity paradigms. The utility of the reaction is demonstrated in drug intermediate synthesis and late-stage functionalization...
October 13, 2016: Journal of the American Chemical Society
Paulo S Pinheiro, Sébastien Houy, Jakob B Sørensen
The molecular mechanisms for calcium-triggered membrane fusion have long been sought for, and detailed models now exist that account for at least some of the functions of the many proteins involved in the process. Key players in the fusion reaction are a group of proteins that, upon binding to calcium, trigger the merger of cargo-filled vesicles with the plasma membrane. Low-affinity, fast-kinetics calcium sensors of the synaptotagmin family - especially synaptotagmin-1 and synaptotagmin-2 - are the main calcium sensors for fast exocytosis triggering in many cell types...
October 12, 2016: Journal of Neurochemistry
K S Mikkonen, D Merger, P Kilpeläinen, L Murtomäki, U S Schmidt, M Wilhelm
Materials manufacturing industries seek efficient, economic, and sustainable compounds for stabilizing dispersed systems such as emulsions. In this study, novel, abundant biobased hydrocolloids spruce galactoglucomannans (GGM) and birch glucuronoxylans (GX) were obtained from a forestry biorefining process and characterized as versatile stabilizers of rapeseed oil-in-water emulsions. For the first time, GGM and GX isolated by pressurized hot water extraction (PHWE) of spruce and birch saw meal, respectively, were studied in emulsions...
September 27, 2016: Soft Matter
Qinbo Qin, Zhengfa Lai, Liu Cao, Qiong Xiao, YuDe Wang, Shaojun Liu
To better understand genomic changes in the early generations after polyploidisation, we examined the chromosomal consequences of genomic merger in allotetraploid hybrids (4 nF1) (AABB, 4n = 148) of Carassius auratus red var. (RCC) (AA, 2n = 100) (♀) × Megalobrama amblycephala (BSB) (BB, 2n = 48) (♂). Complete loss of the paternal 5S rDNA sequence and the expected number of maternal chromosomal loci were found in 4 nF1, suggesting directional genomic changes occurred in the first generations after polyploidisation...
October 5, 2016: Scientific Reports
(no author information available yet)
Estimates of future growth in the oncology market, a predicted increase of 11% per year in sales, and the need to expand drug-development pipelines to sustain profits have been driving up the value of corporate mergers, such as Pfizer's purchase of Medivation for $14 billion.
September 30, 2016: Cancer Discovery
E Brad Thompson
No abstract text is available yet for this article.
October 2016: Molecular Endocrinology
S Singh, S Reddy, Raj Shrivastva
This study compared the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR) data for total hip replacements (THRs) and total knee replacements (TKRs) from Hospital A [with laminar airflow (LAF)] and Hospital B (without LAF). These hospitals were originally managed by two different trusts that subsequently merged. Consequently, the theatres in Hospital A have always had LAF and those in Hospital B had only conventional ventilation systems. As this merger happened before the establishment of the NJR, it puts us in a unique position, enabling direct comparison of the revision rates for infected hip and knee replacements between the two hospitals that follow similar infection protocols...
September 29, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Jeongeun Jo
After the defeat of the Opium War and the Sino-Japanese War, China's intellectuals realized necessity of modernization (Westernization) to survive in the imperial order of the survival of the fittest. In particular, it was urgent to accept Western medicine and train the doctors who learned Western medicine to change the sick and weary Chinese to be robust. Thus, new occupations of the Western Medicine Group (xiyi, doctors who learned Western medicine) emerged in China. As with the first profession, the new Western Medicine Group tried to define standards of Western medicine and medical profession; however, it was difficult in the absence of the strong central government...
August 2016: Ŭi Sahak
Zhi-Ping Jin, Kenta Hotokezaka, Xiang Li, Masaomi Tanaka, Paolo D'Avanzo, Yi-Zhong Fan, Stefano Covino, Da-Ming Wei, Tsvi Piran
GRB 050709 was the first short Gamma-ray Burst (sGRB) with an identified optical counterpart. Here we report a reanalysis of the publicly available data of this event and the discovery of a Li-Paczynski macronova/kilonova that dominates the optical/infrared signal at t>2.5 days. Such a signal would arise from 0.05 r-process material launched by a compact binary merger. The implied mass ejection supports the suggestion that compact binary mergers are significant and possibly main sites of heavy r-process nucleosynthesis...
September 23, 2016: Nature Communications
Muhammad Waseem Bari, Meng Fanchen, Muhammad Awais Baloch
UNLABELLED: The objective of this study is to examine the direct and indirect effect of management practices (procedural justice, coordination approach, communication system, integration strategy, and coping programs) on merger and acquisition (M&A) performance in the Pakistan banking industry. Psychological contract (PC) acts as a mediator between Management practices and M&A performance. The Present study distributes a structured questionnaire to 700 bank employees of different management cadres...
2016: SpringerPlus
K K Irwin, S Laurent, S Matuszewski, S Vuilleumier, L Ormond, H Shim, C Bank, J D Jensen
Many features of virus populations make them excellent candidates for population genetic study, including a very high rate of mutation, high levels of nucleotide diversity, exceptionally large census population sizes, and frequent positive selection. However, these attributes also mean that special care must be taken in population genetic inference. For example, highly skewed offspring distributions, frequent and severe population bottleneck events associated with infection and compartmentalization, and strong purifying selection all affect the distribution of genetic variation but are often not taken into account...
September 21, 2016: Heredity
Emanuele Berti, Alberto Sesana, Enrico Barausse, Vitor Cardoso, Krzysztof Belczynski
We estimate the potential of present and future interferometric gravitational-wave detectors to test the Kerr nature of black holes through "gravitational spectroscopy," i.e., the measurement of multiple quasinormal mode frequencies from the remnant of a black hole merger. Using population synthesis models of the formation and evolution of stellar-mass black hole binaries, we find that Voyager-class interferometers will be necessary to perform these tests. Gravitational spectroscopy in the local Universe may become routine with the Einstein Telescope, but a 40-km facility like Cosmic Explorer is necessary to go beyond z∼3...
September 2, 2016: Physical Review Letters
Robert Zorec, Vladimir Parpura, Alexei Verkhratsky
The neocortex represents one of the largest estates of the human brain. This structure comprises ~30-40 billions of neurones and even more of non-neuronal cells. Astrocytes, highly heterogeneous homoeostatic glial cells, are fundamental for housekeeping of the brain and contribute to information processing in neuronal networks. Gray matter astrocytes tightly enwrap synapses, contact blood vessels and, naturally, are also in contact with the extracellular space, where convection of fluid takes place. Thus astrocytes receive signals from several distinct extracellular domains and can get excited by numerous mechanisms, which regulate cytosolic concentration of second messengers, such as Ca(2+) and cAMP...
September 14, 2016: Neurochemical Research
Michelle Vu, Annesha White, Virginia P Kelley, Jennifer Kuca Hopper, Cathy Liu
BACKGROUND: The Affordable Care Act (ACA) healthcare reforms, centered on achieving the Centers for Medicare & Medicaid Services (CMS) Triple Aim goals of improving patient care quality and satisfaction, improving population health, and reducing costs, have led to increasing partnerships between hospitals and insurance companies and the implementation of employee wellness programs. Hospitals and insurance companies have opted to partner to distribute the risk and resources and increase coordination of care...
July 2016: American Health & Drug Benefits
Dave Speijer
Current analysis shows that the last eukaryotic common ancestor (LECA) was capable of full meiotic sex. The original eukaryotic life cycle can probably be described as clonal, interrupted by episodic sex triggered by external or internal stressors. The cycle could have started in a highly flexible form, with the interruption of either diploid or haploid clonal growth determined by stress signals only. Eukaryotic sex most likely evolved in response to a high mutation rate, arising from the uptake of the endosymbiont, as this (proto) mitochondrion generated internal reactive oxygen species...
October 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
W Schneiders, U Dittmann, F Hannemann, M Jäger, M Eberlein-Gonska, K D Schaser, H Zwipp, K-P Günther
Background: Since the combination of orthopaedic and traumatology surgery as a single speciality, an extremely wide variety of orthopaedic and trauma surgery centres have been founded in Germany. The present investigation analysed the degree to which additional value has been generated by merging two previously independent university departments - one for orthopaedics, the other for trauma surgery - into a single orthopaedics and trauma surgery centre. Material and Methods: The centre, merged in 1 June 2013, is led by two equal co-chairs (a full professor for orthopaedics and a full professor for trauma surgery)...
September 9, 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"