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https://www.readbyqxmd.com/read/28901268/nrg1-erbb-lost-in-translation-a-new-paradigm-for-lung-cancer
#1
Domenico Trombetta, Antonio Rossi, Federico Pio Fabrizio, A Sparaneo, Paolo Graziano, Vito Michele Fazio, Lucia Anna Muscarella
The ErbB network of receptor tyrosine kinases represents one of the best examples of how the understanding of molecular basis of tumor pathogenesis can give a significant improvement for patients treatment, suggesting new therapeutic options to overcome acquired treatment resistance. This amazing bridge between growth factor receptors and cancer has been consolidated during the last decades through the identification of many driver mutations in the gene key of the RTKs network. Unexpected molecular lesions of the NRG1 gene followed by an aberrant ErbB signaling were recently described as a new molecular features of non-small cell lung cancer, but it has been also sporadically reported in other tumors...
September 11, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28883441/spatio-temporal-patterns-of-the-international-merger-and-acquisition-network
#2
Marco Dueñas, Rossana Mastrandrea, Matteo Barigozzi, Giorgio Fagiolo
This paper analyses the world web of mergers and acquisitions (M&As) using a complex network approach. We use data of M&As to build a temporal sequence of binary and weighted-directed networks for the period 1995-2010 and 224 countries (nodes) connected according to their M&As flows (links). We study different geographical and temporal aspects of the international M&A network (IMAN), building sequences of filtered sub-networks whose links belong to specific intervals of distance or time. Given that M&As and trade are complementary ways of reaching foreign markets, we perform our analysis using statistics employed for the study of the international trade network (ITN), highlighting the similarities and differences between the ITN and the IMAN...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874483/beyond-antitrust-health-care-and-health-insurance-market-trends-and-the-future-of-competition
#3
Sherry A Glied, Stuart H Altman
The United States relies on competition to balance costs and quality in the health care system. But concentration is increasing throughout the hospital, physician, and insurer markets. Midsize community hospitals face declining demand and growing competition from both larger hospitals and smaller freestanding diagnostic and surgical centers, leaving the midsize hospitals vulnerable to closure or merger with other facilities. Competition among insurers has been limited by the development of hospital systems that extend the bargaining power of "must-have" hospitals (those perceived to provide the best care for complex and less common conditions) across local health care markets...
September 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28874481/physician-practice-consolidation-driven-by-small-acquisitions-so-antitrust-agencies-have-few-tools-to-intervene
#4
Cory Capps, David Dranove, Christopher Ody
The growing concentration of physician markets throughout the United States has been raising antitrust concerns, yet the Department of Justice and the Federal Trade Commission have challenged only a small number of mergers and acquisitions in this field. Using proprietary claims data from states collectively containing more than 12 percent of the US population, we found that 22 percent of physician markets were highly concentrated in 2013, according to federal merger guidelines. Most of the increases in physician practice size and market concentration resulted from numerous small transactions, rather than a few large transactions...
September 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28869147/challenges-and-factors-likely-to-promote-coping-as-anticipated-by-nurses-preparing-for-a-merger-of-intensive-and-intermediate-care-units
#5
Mari Salminen-Tuomaala, Liisa Ala-Hynnilä, Kati Hämäläinen, Heikki Ruohomäki
OBJECTIVE: To describe challenges and factors that support coping as anticipated by nursing staff preparing for a merger of intensive and intermediate care units. RESEARCH METHODOLOGY: The method of empathy-based stories was employed to collect data from staff. The stories (n=20) were analysed using inductive content analysis. SETTING: Nursing staff from the cardiac observation and evaluation, intensive care and surgical observation units in a central hospital in Finland...
August 28, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28857974/the-strategic-value-of-affiliation-partnerships-in-securing-future-relevance
#6
Ninfa M Saunders
Finding the best route to navigate the changing landscape of healthcare has become an obsession for many organizations. Their quest to stay competitive, significant, and ultimately relevant is a continuous discovery process. Many hospitals and health systems have considered affiliations and partnerships as important tactical options. Partnerships can range from loose arrangements, such as nonequity collaborations and management agreements, to total affiliation, as in a merger and acquisition. Whichever option an organization decides to pursue, a comprehensive assessment is necessary to find the best partner-the right fit...
October 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28846016/impact-of-merger-and-acquisition-on-university-performance
#7
Amjad Mohamadi Bolbanabad, Ali Mohammad Mosadeghrad, Mohammad Arab, Reza Majdzadeh
PURPOSE: Merger and acquisitions (M&A) widen access to higher education, improve quality of teaching and research, and increase efficiency of higher education institutions. Three big medical universities in Iran merged in 2010. The purpose of this study was to highlight the impact of this acquisition on the performance of Tehran University of Medical Sciences. METHODS: This qualitative study was conducted using semi-structured in-depth interviews with 60 participants from April 2015 to November 2015...
August 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28841683/quantification-of-the-evolution-of-firm-size-distributions-due-to-mergers-and-acquisitions
#8
Sandro Claudio Lera, Didier Sornette
The distribution of firm sizes is known to be heavy tailed. In order to account for this stylized fact, previous economic models have focused mainly on growth through investments in a company's own operations (internal growth). Thereby, the impact of mergers and acquisitions (M&A) on the firm size (external growth) is often not taken into consideration, notwithstanding its potential large impact. In this article, we make a first step into accounting for M&A. Specifically, we describe the effect of mergers and acquisitions on the firm size distribution in terms of an integro-differential equation...
2017: PloS One
https://www.readbyqxmd.com/read/28839913/biological-action-in-read-write-genome-evolution
#9
REVIEW
James A Shapiro
Many of the most important evolutionary variations that generated phenotypic adaptations and originated novel taxa resulted from complex cellular activities affecting genome content and expression. These activities included (i) the symbiogenetic cell merger that produced the mitochondrion-bearing ancestor of all extant eukaryotes, (ii) symbiogenetic cell mergers that produced chloroplast-bearing ancestors of photosynthetic eukaryotes, and (iii) interspecific hybridizations and genome doublings that generated new species and adaptive radiations of higher plants and animals...
October 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28830481/merger-mania-mergers-and-acquisitions-in-the-generic-drug-sector-from-1995-to-2016
#10
Marc-André Gagnon, Karena D Volesky
BACKGROUND: Drug shortages and increasing generic drug prices are associated with low levels of competition. Mergers and acquisitions impact the level of competition. Record merger and acquisition activity was reported for the pharmaceutical sector in 2014/15, yet information on mergers and acquisitions in the generic drug sector are absent from the literature. This information is necessary to understand if and how such mergers and acquisitions can be a factor in drug shortages and increasing prices...
August 22, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28813502/addressing-the-challenge-of-high-priced-prescription-drugs-in-the-era-of-precision-medicine-a-systematic-review-of-drug-life-cycles-therapeutic-drug-markets-and-regulatory-frameworks
#11
Toon van der Gronde, Carin A Uyl-de Groot, Toine Pieters
CONTEXT: Recent public outcry has highlighted the rising cost of prescription drugs worldwide, which in several disease areas outpaces other health care expenditures and results in a suboptimal global availability of essential medicines. METHOD: A systematic review of Pubmed, the Financial Times, the New York Times, the Wall Street Journal and the Guardian was performed to identify articles related to the pricing of medicines. FINDINGS: Changes in drug life cycles have dramatically affected patent medicine markets, which have long been considered a self-evident and self-sustainable source of income for highly profitable drug companies...
2017: PloS One
https://www.readbyqxmd.com/read/28813416/large-turbulent-reservoirs-of-cold-molecular-gas-around-high-redshift-starburst-galaxies
#12
E Falgarone, M A Zwaan, B Godard, E Bergin, R J Ivison, P M Andreani, F Bournaud, R S Bussmann, D Elbaz, A Omont, I Oteo, F Walter
Starburst galaxies at the peak of cosmic star formation are among the most extreme star-forming engines in the Universe, producing stars over about 100 million years (ref. 2). The star-formation rates of these galaxies, which exceed 100 solar masses per year, require large reservoirs of cold molecular gas to be delivered to their cores, despite strong feedback from stars or active galactic nuclei. Consequently, starburst galaxies are ideal for studying the interplay between this feedback and the growth of a galaxy...
August 14, 2017: Nature
https://www.readbyqxmd.com/read/28792571/-improving-population-mental-health-by-integrating-mental-health-care-into-primary-care
#13
Matthew Menear, Michel Gilbert, Marie-Josée Fleury
Objective The objectives of this review were to identify and compare major international initiatives aiming to integrate mental health services in primary care and to summarize the lessons learned for similar integration efforts in the province of Quebec, Canada.Methods We conducted a narrative review of the literature guided by a conceptual framework drawn from the literature on integrated care. We identified relevant initiatives to support primary mental health care integration through Pubmed searches and through previous systematic reviews on this topic...
2017: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/28790842/association-of-fhit-expression-and-fhit-gene-hypermethylation-with-liver-cancer-risk-a-prisma-compliant-meta-analysis
#14
Yaping Zhang, Xiao Xu, Zhiliang Chen, Zhenhua Zhao
BACKGROUND: There have been suggestions that fragile histidine triad protein (FHIT) expression and FHIT gene hypermethylation were crucial to the pathogenesis of liver cancer. However, the conclusions remained unclear because of small sample size, disease subtype, and different detection techniques. Therefore, we performed a meta-analysis to estimate the associations of FHIT expression and FHIT gene hypermethylation with liver cancer pathogenesis. METHODS: Studies that were published in electronic databases, such as PubMed, Web of Knowledge, China National Knowledge Infrastructure (CNKI), VIP, and WanFang, were retrieved and selected for the meta-analysis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28780856/direct-aldehyde-c-h-arylation-and-alkylation-via-the-combination-of-nickel-hydrogen-atom-transfer-and-photoredox-catalysis
#15
Xiaheng Zhang, David W C MacMillan
A mechanism that enables direct aldehyde C-H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally simple protocol transforms a wide variety of commercially available aldehydes, along with aryl or alkyl bromides, into the corresponding ketones in excellent yield. This C-H abstraction coupling technology has been successfully applied to the expedient synthesis of the medicinal agent haloperidol.
August 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28780664/unique-sequence-organization-and-small-rna-expression-of-a-selfish-b-chromosome
#16
Yue Li, Xueyuan A Jing, John C Aldrich, C Clifford, Jian Chen, Omar S Akbari, Patrick M Ferree
B chromosomes are found in numerous plants and animals. These nonessential, supernumerary chromosomes are often composed primarily of noncoding DNA repeats similar to those found within transcriptionally "silenced" heterochromatin. In order to persist within their resident genomes, many B chromosomes exhibit exceptional cellular behaviors, including asymmetric segregation into gametes and induction of genome elimination during early development. An important goal in understanding these behaviors is to identify unique B chromosome sequences and characterize their transcriptional contributions...
August 5, 2017: Chromosoma
https://www.readbyqxmd.com/read/28737444/evolving-patterns-in-a-collaboration-network-of-global-r-d-on-monoclonal-antibodies
#17
Xiangjun Kong, Jian-Bo Wan, Hao Hu, Shibing Su, Yuanjia Hu
We investigated the evolution process of collaborative inter-organizational network of the research and development (R&D) on monoclonal antibody (mAb) over the past 30 y. The annual detection of the collaboration network provides dynamics on network structures and relationship changes among different organizations. Our research showed continuous growth of the network's scale and complexity due to the constant entry of new organizations and the forging of new partnering relationships. The evolving topological features reveal a core-periphery structure that became clearer over time and an increasing heterogeneity within the collaborative mAb R&D network...
July 24, 2017: MAbs
https://www.readbyqxmd.com/read/28701875/converting-panax-ginseng-dna-and-chemical-fingerprints-into-two-dimensional-barcode
#18
Yong Cai, Peng Li, Xi-Wen Li, Jing Zhao, Hai Chen, Qing Yang, Hao Hu
BACKGROUND: In this study, we investigated how to convert the Panax ginseng DNA sequence code and chemical fingerprints into a two-dimensional code. In order to improve the compression efficiency, GATC2Bytes and digital merger compression algorithms are proposed. METHODS: HPLC chemical fingerprint data of 10 groups of P. ginseng from Northeast China and the internal transcribed spacer 2 (ITS2) sequence code as the DNA sequence code were ready for conversion. In order to convert such data into a two-dimensional code, the following six steps were performed: First, the chemical fingerprint characteristic data sets were obtained through the inflection filtering algorithm...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28699744/design-synthesis-and-pharmacokinetics-of-a-bone-targeting-dual-action-prodrug-for-the-treatment-of-osteoporosis
#19
Haibo Xie, Gang Chen, Robert N Young
A dual-action bone-targeting prodrug has been designed, synthesized, and evaluated for in vitro and in vivo metabolic stability, in vivo tissue distribution, and rates of release of the active constituents after binding to bones through the use of differentially double-labeled derivatives. The conjugate (general structure 7) embodies the merger of a very potent and proven anabolic selective agonist of the prostaglandin EP4 receptor, compound 5, and alendronic acid, a potent inhibitor of bone resorption, optimally linked through a differentially hydrolyzable linker unit, N-4-carboxymethylphenyl-methyloxycarbonyl-leucinyl-argininyl-para-aminophenylmethylalcohol (Leu-Arg-PABA)...
August 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28698605/appearance-of-unstable-monopoly-state-caused-by-selective-and-concentrative-mergers-in-business-networks
#20
Hayato Goto, Eduardo Viegas, Henrik Jeldtoft Jensen, Hideki Takayasu, Misako Takayasu
Recently, growth mechanism of firms in complex business networks became new targets of scientific study owing to increasing availability of high quality business firms' data. Here, we paid attention to comprehensive data of M&A events for 40 years and derived empirical laws by applying methods and concepts of aggregation dynamics of aerosol physics. It is found that the probability of merger between bigger firms is bigger than that between smaller ones, and such tendency is enhancing year by year. We introduced a numerical model simulating the whole ecosystem of firms and showed that the system is already in an unstable monopoly state in which growth of middle sized firms are suppressed...
July 11, 2017: Scientific Reports
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