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G Liu, L Chang, Y Xin, H Yang, X H Zhang, Z C Chen, Q Zhang
The clinical data of a case of Ramsay Hunt syndrome concurrent with ipsilateral Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ cranial nerves paralysis with throat as starting place was retrospectively analyzed, and the relevant literatures were also reviewed. The case is rare, so the relevant clinical reports are less. It is important to take the objective data as well as subjective symptoms of the patients into consideration to make a definite diagnosis, so that we can treat it as soon as possible to achieve better curative effect...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Richard Menger, Brenton Pennicooke, Todd Barnes, Sarah Fouke, Phillip Kissel, Thomas Origitano, Ramin Rak, Edie Zusman, Jeffrey Cozzens, Andrew Grande, Steven Toms, Sharon Webb, Sherry Taylor
No abstract text is available yet for this article.
June 1, 2018: Neurosurgery
Johan Høy Jensen, Esben Meulengracht Flachs, Janne Skakon, Naja Hulvej Rod, Jens Peter Bonde
OBJECTIVES: We investigated work-unit exit, total and long-term sickness absence following organisational change among public healthcare employees. METHODS: The study population comprised employees from the Capital Region of Denmark (n=14 388). Data on reorganisation at the work-unit level (merger, demerger, relocation, change of management, employee layoff or budget cut) between July and December 2013 were obtained via surveys distributed to the managers of each work unit...
May 14, 2018: Occupational and Environmental Medicine
Aviva Regev, Aman Mahajan
As health care reform shifts toward value over volume, academic medical centers, known for highly specialized, high-cost care, will suffer from erosion of their traditional funding sources. Academic medical centers have undertaken mergers and partnerships with community medical centers, to maintain a more diversified, cost-effective, and competitive presence in their markets. These consolidations have seen varying results. Cultural factors are frequently cited as a cause of dysfunction and disintegration. Anesthesiology groups integrating academic and private practice physicians are likely to face many of the same challenges...
June 2018: Anesthesiology Clinics
Lionel London, Sebastian Khan, Edward Fauchon-Jones, Cecilio García, Mark Hannam, Sascha Husa, Xisco Jiménez-Forteza, Chinmay Kalaghatgi, Frank Ohme, Francesco Pannarale
Gravitational-wave observations of binary black holes currently rely on theoretical models that predict the dominant multipoles (ℓ=2,|m|=2) of the radiation during inspiral, merger, and ringdown. We introduce a simple method to include the subdominant multipoles to binary black hole gravitational waveforms, given a frequency-domain model for the dominant multipoles. The amplitude and phase of the original model are appropriately stretched and rescaled using post-Newtonian results (for the inspiral), perturbation theory (for the ringdown), and a smooth transition between the two...
April 20, 2018: Physical Review Letters
Carl L Rodriguez, Pau Amaro-Seoane, Sourav Chatterjee, Frederic A Rasio
We present models of realistic globular clusters with post-Newtonian dynamics for black holes. By modeling the relativistic accelerations and gravitational-wave emission in isolated binaries and during three- and four-body encounters, we find that nearly half of all binary black hole mergers occur inside the cluster, with about 10% of those mergers entering the LIGO/Virgo band with eccentricities greater than 0.1. In-cluster mergers lead to the birth of a second generation of black holes with larger masses and high spins, which, depending on the black hole natal spins, can sometimes be retained in the cluster and merge again...
April 13, 2018: Physical Review Letters
Eemeli Annala, Tyler Gorda, Aleksi Kurkela, Aleksi Vuorinen
The detection of gravitational waves originating from a neutron-star merger, GW170817, by the LIGO and Virgo Collaborations has recently provided new stringent limits on the tidal deformabilities of the stars involved in the collision. Combining this measurement with the existence of two-solar-mass stars, we generate a generic family of neutron-star-matter equations of state (EOSs) that interpolate between state-of-the-art theoretical results at low and high baryon density. Comparing the results to ones obtained without the tidal-deformability constraint, we witness a dramatic reduction in the family of allowed EOSs...
April 27, 2018: Physical Review Letters
F J Fattoyev, J Piekarewicz, C J Horowitz
The historical first detection of a binary neutron star merger by the LIGO-Virgo Collaboration [B. P. Abbott et al., Phys. Rev. Lett. 119, 161101 (2017)PRLTAO0031-900710.1103/PhysRevLett.119.161101] is providing fundamental new insights into the astrophysical site for the r process and on the nature of dense matter. A set of realistic models of the equation of state (EOS) that yield an accurate description of the properties of finite nuclei, support neutron stars of two solar masses, and provide a Lorentz covariant extrapolation to dense matter are used to confront its predictions against tidal polarizabilities extracted from the gravitational-wave data...
April 27, 2018: Physical Review Letters
Michael S Kinch, Rebekah H Griesenauer
An overview of drugs approved by the FDA in 2017 reflected a reversion to the mean after a low number of NME approvals in 2016. This reversal was largely driven by the largest number of biologics-based NMEs recorded to date, which offset an average number of small-molecule approvals. Oncology indications continued to dominate followed by novel treatments for infectious, immunologic and neurologic diseases. From a mechanistic standpoint, the industry has continued a trend of target diversification, reflecting advances in scientific understanding of disease processes...
May 8, 2018: Drug Discovery Today
Travis L Robbins
No abstract text is available yet for this article.
May 8, 2018: Military Medicine
Carolina Euán, Hernando Ombao, Joaquín Ortega
This paper addresses the problem of identifying brain regions with similar oscillatory patterns detected from electroencephalograms. We introduce the hierarchical spectral merger (HSM) clustering method where the feature of interest is the spectral curve and the similarity metric used is the total variance distance. The HSM method is compared with clustering using features derived from independent-component analysis. Moreover, the HSM method is applied to 2 different electroencephalogram datasets. The first was recorded at resting state where the participant was not engaged in any cognitive task; the second was recorded during a spontaneous epileptic seizure...
May 3, 2018: Statistics in Medicine
Z H Wang, Y Ye, Z Shen, L G Sun, L Hu, W L Yu, M Xu, Z F Sun, J D Cheng, X Sun
Objective: To investigate the application of Symptom Checklist-90 (SCL-90) in Chinese nurses. Methods: We performed a literature search for articles in Chinese on the mental health of nurses investigated using the SCL-90 that were published from January 2007 to December 2016. A total of 129 articles were included, involving 178 groups of valid samples as well as 36316 subjects in 27 provinces or cities in China. The metafor package of R 3.2.1 software and Excel were used for meta-analysis and data statistics...
February 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
Kotaro Takahagi, Komaki Inoue, Minami Shimizu, Yukiko Uehara-Yamaguchi, Yoshihiko Onda, Keiichi Mochida
Background: Allopolyploid plants often show wider environmental tolerances than their ancestors; this is expected to be due to the merger of multiple distinct genomes with a fixed heterozygosity. The complex homoeologous gene expression could have been evolutionarily advantageous for the adaptation of allopolyploid plants. Despite multiple previous studies reporting homoeolog-specific gene expression in allopolyploid species, there are no clear examples of homoeolog-specific function in acclimation to a long-term stress condition...
April 1, 2018: GigaScience
Luca Amendola, Martin Kunz, Ippocratis D Saltas, Ignacy Sawicki
The coincident detection of gravitational waves (GW) and a gamma-ray burst from a merger of neutron stars has placed an extremely stringent bound on the speed of GWs. We showed previously that the presence of gravitational slip (η) in cosmology is intimately tied to modifications of GW propagation. This new constraint implies that the only remaining viable source of gravitational slip is a conformal coupling to gravity in scalar-tensor theories, while viable vector-tensor theories cannot now generate gravitational slip at all...
March 30, 2018: Physical Review Letters
Hang Yu, Denis Martynov, Salvatore Vitale, Matthew Evans, David Shoemaker, Bryan Barr, Giles Hammond, Stefan Hild, James Hough, Sabina Huttner, Sheila Rowan, Borja Sorazu, Ludovico Carbone, Andreas Freise, Conor Mow-Lowry, Katherine L Dooley, Paul Fulda, Hartmut Grote, Daniel Sigg
We propose an upgrade to Advanced LIGO (aLIGO), named LIGO-LF, that focuses on improving the sensitivity in the 5-30 Hz low-frequency band, and we explore the upgrade's astrophysical applications. We present a comprehensive study of the detector's technical noises and show that with technologies currently under development, such as interferometrically sensed seismometers and balanced-homodyne readout, LIGO-LF can reach the fundamental limits set by quantum and thermal noises down to 5 Hz. These technologies are also directly applicable to the future generation of detectors...
April 6, 2018: Physical Review Letters
Nathan J Gesmundo, Bérengère Sauvagnat, Patrick J Curran, Matthew P Richards, Christine L Andrews, Peter J Dandliker, Tim Cernak
Most drugs are developed through iterative rounds of chemical synthesis and biochemical testing to optimize the affinity of a particular compound for a protein target of therapeutic interest. This process is challenging because candidate molecules must be selected from a chemical space of more than 1060 drug-like possibilities 1 , and a single reaction used to synthesize each molecule has more than 107 plausible permutations of catalysts, ligands, additives and other parameters 2 . The merger of a method for high-throughput chemical synthesis with a biochemical assay would facilitate the exploration of this enormous search space and streamline the hunt for new drugs and chemical probes...
April 23, 2018: Nature
F Müller-Sánchez, R Nevin, J M Comerford, R I Davies, G C Privon, E Treister
Theoretical models and numerical simulations have established a framework of galaxy evolution in which galaxies merge and create dual supermassive black holes (with separations of one to ten kiloparsecs), which eventually sink into the centre of the merger remnant, emit gravitational waves and coalesce. The merger also triggers star formation and supermassive black hole growth, and gas outflows regulate the stellar content1-3 . Although this theoretical picture is supported by recent observations of starburst-driven and supermassive black hole-driven outflows4-6 , it remains unclear how these outflows interact with the interstellar medium...
April 2018: Nature
Elyas Goli, Ian D Robertson, Philippe H Geubelle, Jeffrey S Moore
As frontal polymerization is being considered as a faster and more energy efficient manufacturing technique for polymer-matrix fiber-reinforced composites, we perform a finite-element-based numerical study of the initiation and propagation of a polymerization front in dicyclopentadiene (DCPD). The transient thermochemical simulations are complemented by an analytical study of the steady-state propagation of the polymerization front, allowing to draw a direct link between the cure kinetics model and the key characteristics of the front, i...
April 17, 2018: Journal of Physical Chemistry. B
Nicholas A Till, Russell T Smith, David W C MacMillan
The merger of open- and closed-shell elementary organometallic steps has enabled the selective intermolecular addition of nucleophilic radicals to unactivated alkynes. A range of carboxylic acids can be subjected to a CO2 extrusion, nickel capture, migratory insertion sequence with terminal and internal alkynes to generate stereodefined functionalized olefins. This platform has been further extended, via hydrogen atom transfer, to the direct vinylation of unactivated C-H bonds. Preliminary studies indicate that a Ni-alkyl migratory insertion is likely operative...
April 17, 2018: Journal of the American Chemical Society
P T O'Brien, P Evans
The dawn of the gravitational-wave (GW) era has sparked a greatly renewed interest into possible links between sources of high-energy radiation and GWs. The most luminous high-energy sources-gamma-ray bursts (GRBs)-have long been considered as very likely sources of GWs, particularly from short-duration GRBs, which are thought to originate from the merger of two compact objects such as binary neutron stars and a neutron star-black hole binary. In this paper, we discuss: (i) the high-energy emission from short-duration GRBs; (ii) what other sources of high-energy radiation may be observed from binary mergers; and (iii) how searches for high-energy electromagnetic counterparts to GW events are performed with current space facilities...
May 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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