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https://www.readbyqxmd.com/read/29332973/metabologenomics-of-phaeochromocytoma-and-paraganglioma-an-integrated-approach-for-personalised-biochemical-and-genetic-testing
#1
REVIEW
Graeme Eisenhofer, Barbara Klink, Susan Richter, Jacques Wm Lenders, Mercedes Robledo
The tremendous advances over the past two decades in both clinical genetics and biochemical testing of chromaffin cell tumours have led to new considerations about how these aspects of laboratory medicine can be integrated to improve diagnosis and management of affected patients. With germline mutations in 15 genes now identified to be responsible for over a third of all cases of phaeochromocytomas and paragangliomas, these tumours are recognised to have one of the richest hereditary backgrounds among all neoplasms...
April 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/29332145/the-experiences-and-beliefs-of-older-people-in-scottish-very-sheltered-housing-about-using-multi-compartment-compliance-aids
#2
Derek Stewart, Kathrine Gibson Smith, Joan MacLeod, Alison Strath, Vibhu Paudyal, Katrina Forbes-McKay, Scott Cunningham, Katie MacLure
Background Multi-compartment compliance aids (MCAs) are promoted as a potential solution to medicines non-adherence despite the absence of high quality evidence of effectiveness of MCA use impacting medicines adherence or any clinical outcomes. Furthermore, there is a lack of qualitative research which focuses on the perspectives of older people receiving MCAs. Objectives To describe experiences and beliefs surrounding very sheltered housing (VSH) residents' use of MCAs with emphasis on issues of personalisation, reablement, shared decision-making, independence and support...
January 13, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29326331/predicting-response-to-oxygen-therapy-in-obstructive-sleep-apnoea-patients-using-a-10-minute-daytime-test
#3
David Wang, Keith K Wong, Luke Rowsell, Garrick W Don, Brendon J Yee, Ronald R Grunstein
There is no satisfactory treatment for obstructive sleep apnoea (OSA). Supplemental low-flow oxygen therapy (LFO2) has been shown to reduce hypoxaemia and is well tolerated by patients with OSA. However, oxygen therapy may be beneficial only to certain subsets of patients with OSA. In this study, we evaluated a 10-min awake ventilatory chemoreflex test in predicting individual OSA response to 2 months of LFO2 therapy.At baseline, patients with OSA underwent ventilatory chemoreflex testing in the afternoon, prior to the overnight polysomnography...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29322406/utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-preclinical-evaluation-of-therapies-in-cancer
#4
William Berry, Daniel Croagh
Personalising cancer therapy is a way of improving treatment efficacy, by selecting specific treatments for patients with certain molecular changes to their tumour. This requires both molecular material to detect these targets and a preclinical disease model to demonstrate treatment efficacy. In pancreatic cancer this is problematic, as most patients present with advanced disease and are therefore ineligible for surgery. As a result, biological material derived from such patients has been excluded from all preclinical studies in personalised medicine...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29311660/defining-phenotypes-in-diabetic-nephropathy-a-novel-approach-using-a-cross-sectional-analysis-of-a-single-centre-cohort
#5
Rosa M Montero, Athula Herath, Ashfaq Qureshi, Ehsanollah Esfandiari, Charles D Pusey, Andrew H Frankel, Frederick W K Tam
The global increase in Diabetes Mellitus (DM) has led to an increase in DM-Chronic Kidney Disease (DM-CKD). In this cross-sectional observational study we aimed to define phenotypes for patients with DM-CKD that in future may be used to individualise treatment We report 4 DM-CKD phenotypes in 220 patients recruited from Imperial College NHS Trust clinics from 2004-2012. A robust principal component analysis (PCA) was used to statistically determine clusters with phenotypically different patients. 163 patients with complete data sets were analysed: 77 with CKD and 86 with DM-CKD...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310484/pathology-proteomics-and-the-pathway-to-personalised-medicine
#6
Ping Jin, Jiang Lan, Kui Wang, Mark S Baker, Canhua Huang, Edouard C Nice
As we move from a discovery to a translational phase in proteomics, with a focus on developing validated clinical assays to assist personalized medicine, there is a growing need for strong bidirectional interactions with the clinical pathology community. Thus, while on one hand the proteomics community will provide candidate biomarkers to assist in diagnosis, prognosis, surveillance, identification of individualized patient medication and development and validation of new assays for diagnostic use, on the other the pathology community will assist with specific tissue identification and selection (e...
January 8, 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29301783/2017-eular-recommendations-for-a-core-data-set-to-support-observational-research-and-clinical-care-in-rheumatoid-arthritis
#7
Helga Radner, Katerina Chatzidionysiou, Elena Nikiphorou, Laure Gossec, Kimme L Hyrich, Condruta Zabalan, Yvonne van Eijk-Hustings, Paula R Williamson, Andra Balanescu, Gerd R Burmester, Loreto Carmona, Maxime Dougados, Axel Finckh, Glenn Haugeberg, Merete Lund Hetland, Susan Oliver, Duncan Porter, Karim Raza, Patrick Ryan, Maria Jose Santos, Annette van der Helm-van Mil, Piet van Riel, Gabrielle von Krause, Jakub Zavada, William G Dixon, Johan Askling
Personalised medicine, new discoveries and studies on rare exposures or outcomes require large samples that are increasingly difficult for any single investigator to obtain. Collaborative work is limited by heterogeneities, both what is being collected and how it is defined. To develop a core set for data collection in rheumatoid arthritis (RA) research which (1) allows harmonisation of data collection in future observational studies, (2) acts as a common data model against which existing databases can be mapped and (3) serves as a template for standardised data collection in routine clinical practice to support generation of research-quality data...
January 4, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29300377/representing-a-revolution-how-the-popular-press-has-portrayed-personalized-medicine
#8
Alessandro R Marcon, Mark Bieber, Timothy Caulfield
PurposeThis study investigated the portrayal of "personalized" and "precision" medicine (PM) in North American news over the past decade. Content analysis of print and online news was conducted to determine how PM has been defined and to identify the frames used to discuss PM, including associated topics, benefits, and concerns.MethodsA data set was built using the FACTIVA database, searching for popular North American publications with the terms "personalized (personalised) medicine" and/or "precision medicine" from 1 January 2005 to 15 March 2016...
January 4, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29297387/personalised-fluid-resuscitation-in-the-icu-still-a-fluid-concept
#9
REVIEW
Frank van Haren
The administration of intravenous fluid to critically ill patients is one of the most common, but also one of the most fiercely debated, interventions in intensive care medicine. Even though many thousands of patients have been enrolled in large trials of alternative fluid strategies, consensus remains elusive and practice is widely variable. Critically ill patients are significantly heterogeneous, making a one size fits all approach unlikely to be successful.New data from basic, animal, and clinical research suggest that fluid resuscitation could be associated with significant harm...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29278439/investigating-barriers-to-immunosuppressant-medication-adherence-in-renal-transplant-patients
#10
Amelia R Cossart, Christine E Staatz, Scott B Campbell, Nicole M Isbel, W Neil Cottrell
BACKGROUND: Immunosuppressant medication non-adherence can result in allograft rejection and loss. The aim of this study was to investigate the prevalence of non-adherence and barriers to adherence with immunosuppressant medications, in an adult renal transplant cohort. METHODS: Kidney transplant recipients completed a self-report survey consisting of five validated questionnaires (Basel Assessment of Adherence Immunosuppression Scale (BAASIS), Beliefs about Medicines Questionnaire, Immunosuppressant Therapy Barrier Scale, Brief-Illness Perception Questionnaire, and Multidimensional Health Locus of Control Scale), and provided sociodemographic information...
December 26, 2017: Nephrology
https://www.readbyqxmd.com/read/29275870/personalised-medicine-in-the-uk
#11
EDITORIAL
The Lancet
No abstract text is available yet for this article.
December 21, 2017: Lancet
https://www.readbyqxmd.com/read/29273576/opinion-redefining-the-role-of-the-physician-in-laboratory-medicine-in-the-context-of-emerging-technologies-personalised-medicine-and-patient-autonomy-4p-medicine
#12
REVIEW
Matthias Orth, Maria Averina, Stylianos Chatzipanagiotou, Gilbert Faure, Alexander Haushofer, Vesna Kusec, Augusto Machado, Siraj A Misbah, Wytze Oosterhuis, Kari Pulkki, Patrick J Twomey, Eberhard Wieland
The role of clinical pathologists or laboratory-based physicians is being challenged on several fronts-exponential advances in technology, increasing patient autonomy exercised in the right to directly request tests and the use of non-medical specialists as substitutes. In response, clinical pathologists have focused their energies on the pre-analytical and postanalytical phases of Laboratory Medicine thus emphasising their essential role in individualised medical interpretation of complex laboratory results...
December 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29259772/genetics-in-the-21st-century-implications-for-patients-consumers-and-citizens
#13
Jonathan Roberts, Anna Middleton
The first human genome project, completed in 2003, uncovered the genetic building blocks of humankind. Painstakingly cataloguing the basic constituents of our DNA ('genome sequencing') took ten years, over three billion dollars and was a multinational collaboration. Since then, our ability to sequence genomes has been finessed so much that by 2017 it is possible to explore the 20,000 or so human genes for under £1000, in a matter of days. Such testing offers clues to our past, present and future health, as well as information about how we respond to medications so that truly 'personalised medicine' is now a reality...
2017: F1000Research
https://www.readbyqxmd.com/read/29249020/multi-omic-approach-decodes-paradoxes-of-the-triple-negative-breast-cancer-lessons-for-predictive-preventive-and-personalised-medicine
#14
Olga Golubnitschaja, Nora Filep, Kristina Yeghiazaryan, Henricus Johannes Blom, Martin Hofmann-Apitius, Walther Kuhn
Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a particularly aggressive type of breast cancer lacking clear diagnostic approach and targeted therapies. Consequently, more than 50% of the TNBC patients die of the metastatic BC within the first 6 months of the diagnosis...
December 16, 2017: Amino Acids
https://www.readbyqxmd.com/read/29239200/digital-health-and-perioperative-care
#15
Theofanis Fotis
According to the U.S. Food and Drug Administration 'the broad scope of digital health includes categories such as mobile health (mHealth), health information technology (IT), wearable devices, telehealth and telemedicine, and personalised medicine, and is used by providers and other stakeholders in their efforts to reduce inefficiencies, improve access, reduce costs, increase quality, and make medicine more personalised for patients (FDA 2016). More recently, Paul Sonier, a digital health strategist and founder of the Linkedin digital health group with more than 40,000 members, defined digital health as 'the convergence of the digital and genomic revolutions with health, healthcare, living, and society' (storyofdigitalhealth...
June 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29226412/editorial-anti-tnf-therapy-and-myopenia-in-crohn-s-disease-another-step-towards-personalised-medicine
#16
EDITORIAL
C D Murray
No abstract text is available yet for this article.
January 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29226405/editorial-anti-tnf-therapy-and-myopenia-in-crohn-s-disease-another-step-towards-personalised-medicine-authors-reply
#17
EDITORIAL
N S Ding, G Malietzis, A L Hart
No abstract text is available yet for this article.
January 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29225099/point-of-use-production-of-liposomal-solubilised-products
#18
Swapnil Khadke, Peter Stone, Aleksey Rozhin, Jerome Kroonen, Yvonne Perrie
With the progression towards personalised and age-appropriate medicines, the production of drug loaded liposomes at the point of care would be highly desirable. In particular, liposomal solubilisation agents that can be produced rapidly and easily would provide a new option in personalised medicines. Such a process could also be used as a rapid tool for the formulation and pre-clinical screening of low soluble drugs. Within this paper, we outline a novel easy-to-use production method for point of use production of liposome solubilised drugs...
December 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29214584/personalized-medicine-what-s-in-it-for-rare-diseases
#19
Sebastian Schee Genannt Halfmann, Laura Mählmann, Lada Leyens, Matthias Reumann, Angela Brand
Personalised Medicine has become a reality over the last years. The emergence of 'omics' and big data has started revolutionizing healthcare. New 'omics' technologies lead to a better molecular characterization of diseases and a new understanding of the complexity of diseases. The approach of PM is already successfully applied in different healthcare areas such as oncology, cardiology, nutrition and for rare diseases. However, health systems across the EU are often still promoting the 'one-size fits all' approach, even if it is known that patients do greatly vary in their molecular characteristics and response to drugs and other interventions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29209438/incorporation-of-suboptimal-health-status-as-a-potential-risk-assessment-for-type-ii-diabetes-mellitus-a-case-control-study-in-a-ghanaian-population
#20
Eric Adua, Peter Roberts, Wei Wang
Due to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus (T2DM) will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease-suboptimal health status (SHS). We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people as controls and 241 T2DM patients from January to June 2016...
December 2017: EPMA Journal
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