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https://www.readbyqxmd.com/read/29148178/training-in-molecular-cytopathology-testing
#1
REVIEW
P Maxwell, M Salto-Tellez
Training in molecular cytopathology testing is essential in developing and maintaining skills in modern molecular technologies as they are introduced to a universal health care system such as extant in the UK and elsewhere. We review the system in place in Northern Ireland (NI) for molecular testing of solid tumours, as an example to train staff of all grades, including pathologists, clinical scientists, biomedical scientists and equivalent technical grades. We describe training of pathologists as part of the NI Deanery medical curriculum, the NI training programme for scientists and laboratory rotation for Biomedical Scientists...
November 17, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29146652/dynamic-treatment-selection-and-modification-for-personalised-blood-pressure-therapy-using-a-markov-decision-process-model-a-cost-effectiveness-analysis
#2
Sung Eun Choi, Margaret L Brandeau, Sanjay Basu
OBJECTIVE: Personalised medicine seeks to select and modify treatments based on individual patient characteristics and preferences. We sought to develop an automated strategy to select and modify blood pressure treatments, incorporating the likelihood that patients with different characteristics would benefit from different types of medications and dosages and the potential severity and impact of different side effects among patients with different characteristics. DESIGN, SETTING AND PARTICIPANTS: We developed a Markov decision process (MDP) model to incorporate meta-analytic data and estimate the optimal treatment for maximising discounted lifetime quality-adjusted life-years (QALYs) based on individual patient characteristics, incorporating medication adjustment choices when a patient incurs side effects...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146439/risk-stratification-after-paracetamol-overdose-using-mechanistic-biomarkers-results-from-two-prospective-cohort-studies
#3
James W Dear, Joanna I Clarke, Ben Francis, Lowri Allen, Jonathan Wraight, Jasmine Shen, Paul I Dargan, David Wood, Jamie Cooper, Simon H L Thomas, Andrea L Jorgensen, Munir Pirmohamed, B Kevin Park, Daniel J Antoine
BACKGROUND: Paracetamol overdose is common but patient stratification is suboptimal. We investigated the usefulness of new biomarkers that have either enhanced liver specificity (microRNA-122 [miR-122]) or provide mechanistic insights (keratin-18 [K18], high mobility group box-1 [HMGB1], and glutamate dehydrogenase [GLDH]). The use of these biomarkers could help stratify patients for their risk of liver injury at hospital presentation. METHODS: Using data from two prospective cohort studies, we assessed the potential for biomarkers to stratify patients who overdose with paracetamol...
November 13, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29145038/precision-medicine-for-patients-with-advanced-biliary-tract-cancers-an-effective-strategy-within-the-prospective-moscato-01-trial
#4
Loic Verlingue, David Malka, Adrien Allorant, Christophe Massard, Charles Ferté, Ludovic Lacroix, Etienne Rouleau, Nathalie Auger, Maud Ngo, Claudio Nicotra, Thierry De Baere, Lambros Tselikas, Bakar Ba, Stefan Michiels, Jean-Yves Scoazec, Valérie Boige, Michel Ducreux, Jean-Charles Soria, Antoine Hollebecque
BACKGROUND: Recommended treatments of patients with advanced biliary tract cancer (aBTC) are limited to one chemotherapy doublet. Nevertheless, efficacy of treatment personalisation for aBTCs is supported by accumulating evidences but remains to be evaluated. PATIENTS AND METHODS: Patients with aBTCs included in the prospective clinical trial MOSCATO-01 were treated by at least one previous systemic treatment, had an ECOG performance status of 0-1, and at least one tumour site accessible to biopsy...
November 13, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29141962/personalised-medicine-for-nonsmall-cell-lung-cancer
#5
Céline Mascaux, Pascale Tomasini, Laurent Greillier, Fabrice Barlesi
After years of standard care prescribed to cancer patients without any selection except the primary site and histology of the tumour, the era of precision medicine has revolutionised cancer care. Personalised medicine refers to the selection of patients for specific treatment based on the presence of specific biomarkers which indicate sensitivity to corresponding targeted therapies and/or lower toxicity risk, such that patients will have the greatest chance of deriving benefit from the treatments. Here, we review personalised medicine for nonsmall cell lung cancer...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29140430/the-european-society-for-medical-oncology-esmo-precision-medicine-glossary
#6
L R Yates, J Seoane, C Le Tourneau, L L Siu, R Marais, S Michiels, J C Soria, P Campbell, N Normanno, A Scarpa, J S Reis-Filho, J Rodon, C Swanton, F Andre
Background: Precision medicine is rapidly evolving within the field of oncology and has brought many new concepts and terminologies that are often poorly defined when first introduced, which may subsequently lead to miscommunication within the oncology community. The European Society for Medical Oncology (ESMO) recognises these challenges and is committed to support the adoption of precision medicine in oncology. To add clarity to the language used by oncologists and basic scientists within the context of precision medicine, the ESMO Translational Research and Personalised Medicine Working Group has developed a standardised glossary of relevant terms...
November 13, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29127185/advances-in-computational-modelling-for-personalised-medicine-after-myocardial-infarction
#7
REVIEW
Kenneth Mangion, Hao Gao, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide. Determining which patients will experience heart failure and sudden cardiac death after an acute MI is notoriously difficult for clinicians. The extent of heart damage after an acute MI is informed by cardiac imaging, typically using echocardiography or sometimes, cardiac magnetic resonance (CMR). These scans provide complex data sets that are only partially exploited by clinicians in daily practice, implying potential for improved risk assessment...
November 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29122391/genetics-and-epigenetics-of-nafld-and-nash-clinical-impact
#8
REVIEW
Mohammed Eslam, Luca Valenti, Stefano Romeo
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis, through non-alcoholic steatohepatitis, to fibrosis and ultimately cirrhosis and hepatocellular carcinoma. A hallmark of NAFLD is the substantial inter-patient variation in disease progression. NAFLD is considered a complex disease trait such that interactions between the environment and a susceptible polygenic host background determine disease phenotype and influence progression...
November 2, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29120894/advances-in-pharmacotherapies-for-movement-disorders-in-children-current-limitations-and-future-progress
#9
Jean-Pierre Lin
PURPOSE OF REVIEW: In childhood, movement disorders are generated by a very large number of disorders of the nervous system, and the very different developmental ages at which these occur make studies of pharmacotherapy efficacy extremely difficult. In most clinical practices, medication used in management is by trial and error, and limited by lack of efficacy and/or adverse drug reactions leading to drug intolerance. Nevertheless, symptom reduction using polypharmacy must be balanced against any accompanying comorbidities such as poor attention and concentration, constipation, ileus, urinary retention, blurred vision sedation and respiratory depression...
December 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29106468/endometrial-organoids-in-vitro-models-for-endometrial-research-and-personalised-medicine
#10
James A Deane, Fiona L Cousins, Caroline E Gargett
No abstract text is available yet for this article.
November 2, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29074101/towards-personalised-medicine-in-lung-and-thymus-neuroendocrine-tumours
#11
Giuseppe Pelosi, Judith Cave, Christian H Ottensmeier
No abstract text is available yet for this article.
October 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29070581/personalised-medicine-in-sleep-respiratory-disorders-focus-on-obstructive-sleep-apnoea-diagnosis-and-treatment
#12
Maria R Bonsignore, Monique C Suarez Giron, Oreste Marrone, Alessandra Castrogiovanni, Josep M Montserrat
In all fields of medicine, major efforts are currently dedicated to improve the clinical, physiological and therapeutic understanding of disease, and obstructive sleep apnoea (OSA) is no exception. The personalised medicine approach is relevant for OSA, given its complex pathophysiology and variable clinical presentation, the interactions with comorbid conditions and its possible contribution to poor outcomes. Treatment with continuous positive airway pressure (CPAP) is effective, but CPAP is poorly tolerated or not accepted in a considerable proportion of OSA patients...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29065378/clinical-relevance-of-molecular-diagnostics-in-gastrointestinal-gi-cancer-european-society-of-digestive-oncology-esdo-expert-discussion-and-recommendations-from-the-17th-european-society-for-medical-oncology-esmo-world-congress-on-gastrointestinal-cancer-barcelona
#13
REVIEW
Alexander Baraniskin, Jean-Luc Van Laethem, Lucjan Wyrwicz, Ulrich Guller, Harpreet S Wasan, Tamara Matysiak-Budnik, Thomas Gruenberger, Michel Ducreux, Fatima Carneiro, Eric Van Cutsem, Thomas Seufferlein, Wolff Schmiegel
BACKGROUND AND SCOPE: In the epoch of precision medicine and personalised oncology, which aims to deliver the right treatment to the right patient, molecular genetic biomarkers are a topic of growing interest. The aim of this expert discussion and position paper is to review the current status of various molecular tests for gastrointestinal (GI) cancers and especially considering their significance for the clinical routine use. METHODOLOGY: Opinion leaders and experts from diverse nationalities selected on scientific merit were asked to answer to a prepared set of questions about the current status of molecular diagnostics in different GI cancers...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29062388/highlights-from-the-win-2017-symposium-26-27-june-2017-paris-france-expediting-global-innovation-in-precision-cancer-medicine
#14
Will Davies
The Worldwide Innovative Networking (WIN) symposium brings together representatives from academic institutions, pharmaceutical partners, technology companies and charitable organisations from across the globe for an annual summit, discussing ongoing research and the latest developments in precision medicine. Now, in its seventh year, the aims of the WIN consortium's annual meeting, to foster communication and collaboration between members and deliver clinical trial results that improve the care and outcomes of patients are presented in open dialogue to encourage debate and discussion...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29021195/data-data-everywhere-the-challenges-of-personalised-medicine
#15
Stephen Armstrong
No abstract text is available yet for this article.
October 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28988218/prediction-of-long-term-outcome-subtypes-in-ards-first-steps-towards-personalised-medicine-in-critical-care
#16
EDITORIAL
Nicola Latronico, Cosetta Minelli, Matthias Eikermann
No abstract text is available yet for this article.
December 2017: Thorax
https://www.readbyqxmd.com/read/28974598/molecular-radiotheragnostics-in-thyroid-disease
#17
Nitasha Singh, Val Lewington
Molecular radiotheragnostics directly links nuclear medicine diagnostic imaging to therapy. The imaging study is used to detect a specific molecular target associated with a disease process. A radiotherapeutic molecule with a similar biodistribution to the diagnostic agent can then be used to deliver targeted therapy.Molecular radiotheragnostics have been applied to manage both benign and malignant thyroid disease since the 1940s. The specific molecular pathway targeted is the sodium/iodide symporter (NIS) located on the basolateral membrane of the thyroid follicular cell...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28974597/selective-internal-radiation-therapy-for-liver-tumours
#18
Francis X Sundram, John R Buscombe
Primary and secondary liver malignancies are common and associated with a poor prognosis. Surgical resection is the treatment of choice; however, many patients have unresectable disease. In these cases, several liver directed therapies are available, including selective internal radiation therapy (SIRT). SIRT is a multidisciplinary treatment involving nuclear medicine, interventional radiology and oncology. High doses of localised internal radiation are selectively delivered to liver tumour tissues, with relative sparing of adjacent normal liver parenchyma...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28971621/medical-students-perceptions-of-low-value-care
#19
Christopher Steele, Justin Berk, Bimal Ashar, Amit Pahwa, Danelle Cayea
BACKGROUND: Medical schools are creating high-value care (HVC) curricula in undergraduate medical education; however, there are few studies identifying what are the most pressing low-value care (LVC) practices, as observed by students. This study is a multicentre, targeted needs assessment comparing medical student perceptions of LVC at four institutions, after completion of their internal medicine clerkship, to identify areas of focus for future HVC curriculum development. METHODS: A total of 307 medical students at four institutions participated in a voluntary survey and identified instances of LVC during the internal medicine clerkship...
October 3, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28966692/wearable-technology-role-in-respiratory-health-and-disease
#20
REVIEW
Andrea Aliverti
In the future, diagnostic devices will be able to monitor a patient's physiological or biochemical parameters continuously, under natural physiological conditions and in any environment through wearable biomedical sensors. Together with apps that capture and interpret data, and integrated enterprise and cloud data repositories, the networks of wearable devices and body area networks will constitute the healthcare's Internet of Things. In this review, four main areas of interest for respiratory healthcare are described: pulse oximetry, pulmonary ventilation, activity tracking and air quality assessment...
June 2017: Breathe
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