Akira Ohkoshi, Ryoukichi Ikeda, Jun Suzuki, Takaya Yamamoto, Ryo Ishii, Kenjiro Higashi, Shun Wakamori, Yuki Nakayama, Ayako Nakanome, Takenori Ogawa, Yukio Katori
Ototoxicity is a dose-limiting adverse event for concurrent chemoradiotherapy (CCRT) with high-dose cisplatin for locally advanced head and neck squamous cell carcinoma (HNSCC). Both irradiation to the Eustachian tube (ET) and weight loss are risk factors for patulous ET. The aim of this prospective, observational study was to elucidate the incidences of patulous ET conditions before and after CCRT in HNSCC patients by means of ET function tests. This prospective, observational study was conducted in 27 HNSCC patients who received CCRT with high-dose cisplatin, and ET function tests (sonotubometry and tubo-tympano-aerodynamic graphy) were performed before and 3 months after CCRT...
December 2022: Indian Journal of Otolaryngology and Head and Neck Surgery