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https://www.readbyqxmd.com/read/28532055/gold-nanoparticles-prevent-cognitive-deficits-oxidative-stress-and-inflammation-in-a-rat-model-of-sporadic-dementia-of-alzheimer-s-type
#1
Alexandre Pastoris Muller, Gabriela K Ferreira, Allison José Pires, Gustavo de Bem Silveira, Débora Laureano de Souza, Joice de Abreu Brandolfi, Claudio Teodoro de Souza, Marcos M S Paula, Paulo Cesar Lock Silveira
Alzheimer's disease (AD) is the most common form of neurodegenerative dementia in the aged brain. Even though its etiology is unknown, factors such as neuroinflammation, mitochondrial dysfunction, formation of reactive oxygen species (ROS), and impaired insulin signaling may play a role. We used a sporadic AD model in rats generated by intracerebroventricular-streptozotocin (i.c.v.-STZ) injection to test the therapeutic effect of gold nanoparticles (GNPs). We tested the null hypothesis that there would be no difference between the STZ+GNPs group and the STZ group in the analyzed markers...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531788/association-of-dietary-factors-with-severity-of-coronary-artery-disease
#2
Namita Mahalle, M K Garg, S S Naik, M V Kulkarni
BACKGROUND: Cardiovascular disease has taken epidemic proportions during past decades. Cardiovascular risk factors contribute to progression of coronary lesions, worsening the patient's prognosis. This study was planned to analyze the association of dietary factors with severity of coronary artery disease (CAD) in Indian patients. METHODS: Three hundred patients with known coronary disease above the age of 25 years were included in this study. Blood samples were collected for biochemical markers...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531776/the-nutritional-value-of-food-service-meals-ordered-by-hospitalized-children
#3
Jeannie S Huang, Stanford Chun, Christopher Cheung, Linda Poon, Laura Terrones
BACKGROUND AND AIMS: US hospitals routinely provide food to hospitalized children. The nutritional content of provided foods has not been evaluated. We performed our study to examine meal orders of hospitalized youth and determine whether the nutritional contents of ordered meals meet dietary guidelines. METHODS: We performed a cross-sectional evaluation among hospitalized youth ≥1 y receiving all nutritional intake by mouth and not on a clear liquid diet. Meal orders from hospitalized youth were analyzed for nutritional content...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531342/prognostic-significance-of-preoperative-neutrophilia-on-recurrence-free-survival-in-meningioma
#4
Shirin Karimi, Mana V Vyas, Lior Gonen, Raha Tabasinejad, Quinn Ostrom, Jill Barnholtz-Sloan, Suganth Suppiah, Gelareh Zadeh, Kenneth Aldape
Background: Meningioma is the most common primary intracranial tumor and recurrence is one of the important challenges in patient management. Prognostic factors for tumor recurrences in these patients especially before surgical resection are not fully characterized. Several studies have indicated an association between changes in hematologic laboratory parameters with patient outcomes in solid malignancies. We aimed to assess the association between hematological parameters and tumor recurrence in patients with meningioma...
May 20, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28531319/improved-sperm-kinematics-in-semen-samples-collected-after-2-h-versus-4-7-days-of-ejaculation-abstinence
#5
H Alipour, G Van Der Horst, O B Christiansen, F Dardmeh, N Jørgensen, H I Nielsen, C Hnida
STUDY QUESTION: Does a short abstinence period of only 2 h yield spermatozoa with better motility characteristics than samples collected after 4-7 days? SUMMARY ANSWER: Despite lower semen volume, sperm concentration, total sperm counts and total motile counts, higher percentages of motile spermatozoa with higher velocity and progressiveness were detected in samples obtained after 2 h. WHAT IS KNOWN ALREADY: Most studies that have assessed the effect of abstinence periods on sperm motility parameters in men with a sperm concentration below 15 million/ml have detected a higher percentage of motile spermatozoa in samples obtained after short abstinence periods...
May 22, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28531143/a-4-phenoxyphenol-derivative-exerts-inhibitory-effects-on-human-hepatocellular-carcinoma-cells-through-regulating-autophagy-and-apoptosis-accompanied-by-downregulating-%C3%AE-tubulin-expression
#6
Wen-Tsan Chang, Wangta Liu, Yi-Han Chiu, Bing-Hung Chen, Shih-Chang Chuang, Yen-Chun Chen, Yun-Tzh Hsu, Mei-Jei Lu, Shean-Jaw Chiou, Chon-Kit Chou, Chien-Chih Chiu
Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes. In this study, we showed that a 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activity against two HCC cell lines, Huh7 and Ha22T. We further investigated the anti-HCC activities of 4-HPPP, including anti-proliferation and induction of apoptosis. Our results showed that higher dosage of 4-HPPP downregulates the expression of α-tubulin and causes nuclear enlargement in both the Huh-7 and Ha22T cell lines...
May 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28530713/bach2-immunodeficiency-illustrates-an-association-between-super-enhancers-and-haploinsufficiency
#7
Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun, Ine Vanderleyden, Fred P Davis, Ahmad Khoder, Yu Zhang, Ahmed N Hegazy, Alejandro V Villarino, Ira W Palmer, Joshua Kaufman, Norman R Watts, Majid Kazemian, Olena Kamenyeva, Julia Keith, Anwar Sayed, Dalia Kasperaviciute, Michael Mueller, Jason D Hughes, Ivan J Fuss, Mohammed F Sadiyah, Kim Montgomery-Recht, Joshua McElwee, Nicholas P Restifo, Warren Strober, Michelle A Linterman, Paul T Wingfield, Holm H Uhlig, Rahul Roychoudhuri, Timothy J Aitman, Peter Kelleher, Michael J Lenardo, John J O'Shea, Nichola Cooper, Arian D J Laurence
The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The TF BACH2 is essential for T and B lymphocytes and is associated with an archetypal super-enhancer (SE). Single-nucleotide variants in the BACH2 locus are associated with several autoimmune diseases, but BACH2 mutations that cause Mendelian monogenic primary immunodeficiency have not previously been identified. Here we describe a syndrome of BACH2-related immunodeficiency and autoimmunity (BRIDA) that results from BACH2 haploinsufficiency...
May 22, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28530658/endoglin-controls-blood-vessel-diameter-through-endothelial-cell-shape-changes-in-response-to-haemodynamic-cues
#8
Wade W Sugden, Robert Meissner, Tinri Aegerter-Wilmsen, Roman Tsaryk, Elvin V Leonard, Jeroen Bussmann, Mailin J Hamm, Wiebke Herzog, Yi Jin, Lars Jakobsson, Cornelia Denz, Arndt F Siekmann
The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during zebrafish embryonic development increases in flow, after an initial expansion of blood vessel diameters, eventually lead to vessel contraction...
May 22, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28530463/association-of-il-6-174-g-c-polymorphism-with-the-risk-of-sle-among-south-indians-evidence-from-case-control-study-and-meta-analysis
#9
S K Katkam, L Rajasekhar, K Kumaraswami, V K Kutala
Cytokines play a direct role in disease pathogenesis of systemic lupus erythematosus (SLE). Elevated levels of serum IL-6 are well documented with the disease activity and anti-dsDNA antibodies in SLE. The 5' promoter region of the IL-6 gene has been shown to play a significant role in the regulation of gene expression. In view of this, the current study aimed to investigate the possible association of 5' promoter polymorphisms G-597A (rs1800797), G-572C (rs1800796) and G-174C (rs1800795) with the risk of SLE...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28530392/a-hexafluoroquinoxaline-based-polymer-for-nonfullerene-solar-cells-reaching-9-4-efficiency
#10
Shutao Xu, Liuliu Feng, Jun Yuan, Zhi-Guo Zhang, Yongfang Li, Hongjian Peng, Yingping Zou
hrough introducing six fluorine atoms onto quinoxaline (Qx), a new electron acceptor unit-hexafluoroquinoxaline (HFQx) is firstly synthesized. Based on this unit, we synthesize a new donor-acceptor (D-A) copolymer (HFQx-T), which is composed of benzodithiophene (BDT) derivative donor block and an HFQx accepting block. The strong electron-withdrawing properties of fluorine atoms increase significantly the voltage open-circuit (Voc) by tuning the highest occupied molecular orbital (HOMO) energy level. In addition, fluorine atoms enhance the absorption coefficient of the conjugated copolymer and change the film morphology, which implies an increase of the short-circuit current density (Jsc) and fill factor (FF)...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28530386/controllable-growth-of-ga-film-electrodeposited-from-aqueous-solution-and-cu-in-ga-se2-solar-cells
#11
Jinlian Bi, Jianping Ao, Qing Gao, Zhaojing Zhang, Guozhong Sun, Qing He, Zhiqiang Zhou, Yun Sun, Yi Zhang
Electrodepositon of Ga film is very challenging due to the high standard reduction potential (-0.53 V vs. SHE for Ga3+). In this study, Ga film with compact structure was successfully deposited on Mo/Cu/In substrate by PCE method using GaCl3 aqueous solution. High deposition rate of Ga3+ and H+ can be achieved by applying large overpotential induced by high pulse current. In the meanwhile, the concentration polarization induced by cations depletion can be minimized by changing the pulse frequency and duty-cycle...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28529953/bis-4-4-dimethyl-2-2-bipyridine-oxidovanadium-iv-sulfate-dehydrate-potential-candidate-for-controlling-lipid-metabolism
#12
Renata Francik, Jadwiga Kryczyk-Kozioł, Sławomir Francik, Ryszard Gryboś, Mirosław Krośniak
Vanadium is a trace element mainly connected with regulation of insulin metabolism which is particularly important in diabetes. In recent years, organic complexes of vanadium seem to be more interesting than inorganic salts. Nevertheless, the effect of vanadium on lipid metabolism is still a problematic issue; therefore, the main purpose of this study was to investigate the effect of 3 organic complexes of vanadium such as sodium (2,2'-bipyridine)oxidobisperoxovanadate(V) octahydrate, bis(2,2'-bipyridine)oxidovanadium(IV) sulfate dehydrate, and bis(4,4'-dimethyl-2,2'-bipyridine)oxidovanadium(IV) sulfate dihydrate in conjunction with high-fat as well as control diet in nondiabetes model on the following lipid parameters: total cholesterol, triglycerides, and high density lipoprotein as well as activity of paraoxonase 1...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28529241/downregulation-of-transcription-factor-sp1-suppresses-malignant-properties-of-a549-human-lung-cancer-cell-line-with-decreased-%C3%AE-4-galactosylation-of-highly-branched-n-glycans
#13
Kodai Muramoto, Riho Tange, Takayuki Ishii, Kana Miyauchi, Takeshi Sato
Dramatic changes in the glycan structures of cell surface proteins have been observed upon malignant transformation of cells as induced by the altered expression levels of glycosyltransferases. Such changes are closely associated with the malignant properties of cancer cells. Transcription factor Sp1 regulates the gene expression of various molecules including glycosyltransferases. Herein, we investigated whether or not Sp1-downregulation affects to N-glycosylation of glycoproteins and malignant properties of A549 human lung carcinoma cell line...
May 20, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28529095/understanding-operator-stent-choice-in-the-catheterization-laboratory-using-a-pre-procedure-survey-opportunities-for-quality-improvement
#14
Matthew J Chung, Jonathan D Hansen, Ryan D Schulteis, Joel C Boggan, W Schuyler Jones, Thomas J Povsic, Susan Roberts, Mitchell W Krucoff, Sunil V Rao
OBJECTIVES: We sought to characterize how the perceived risk of early dual antiplatelet therapy (DAPT) discontinuation is incorporated into operator decision-making regarding stent choice, using a simple pre-procedure survey screening for clinical variables that may lead to early DAPT discontinuation. BACKGROUND: Understanding which factors influence operator decision-making regarding stent choice during percutaneous coronary intervention (PCI) could help identify areas for quality improvement...
May 8, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28528939/aga-white-paper-training-and-implementation-of-endoscopic-image-enhancement-technologies
#15
Neil Gupta, Joel V Brill, Marcia Canto, Daniel DeMarco, Brian M Fennerty, Loren Laine, David Lieberman, Charles Lightdale, Elizabeth Montgomery, Robert Odze, Douglas Rex, Prateek Sharma, Jeffrey L Tokar, Michael L Kochman
Endoscopic image-enhancement technologies provide opportunities to visualize normal and abnormal tissues within the gastrointestinal (GI) tract in a manner that complements conventional white light endoscopic imaging. The additional information that is obtained enables the endoscopist to better identify, delineate, and characterize lesions and can facilitate targeted biopsies or, in some cases, eliminate the need to send samples for histologic analysis. Some of these technologies have been available for more than a decade, but despite this fact, there is limited use of these technologies by endoscopists...
June 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28528930/clinical-and-psychosocial-predictors-of-urologic-chronic-pelvic-pain-symptom-change-over-one-year-a-prospective-study-from-the-mapp-research-network
#16
Bruce D Naliboff, Alisa J Stephens, H Henry Lai, James W Griffith, J Quentin Clemens, Susan Lutgendorf, Larissa V Rodriguez, Craig Newcomb, Siobhan Sutcliffe, Wensheng Guo, John W Kusek, J Richard Landis
OBJECTIVE: To examine baseline clinical and psychosocial characteristics that predict 12- month symptom change in men and women with urologic chronic pelvic pain syndromes (UCPPS). METHODS: 221 female and 176 male UCPPS patients were recruited from 6 academic medical centers in the United States and evaluated at baseline with a comprehensive battery of symptom, psychosocial, and illness-impact measures. Based on biweekly symptom reports, a functional clustering procedure classified participant's outcome as worse, stable, or improved on pain and urinary symptom severity...
May 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28528438/herpes-simplex-virus-membrane-fusion
#17
Darin J Weed, Anthony V Nicola
Herpes simplex virus mediates multiple distinct fusion events during infection. HSV entry is initiated by fusion of the viral envelope with either the limiting membrane of a host cell endocytic compartment or the plasma membrane. In the infected cell during viral assembly, immature, enveloped HSV particles in the perinuclear space fuse with the outer nuclear membrane in a process termed de-envelopment. A cell infected with some strains of HSV with defined mutations spread to neighboring cells by a fusion event called syncytium formation...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28528433/hydrolysis-of-phosphatidylcholine-isoprostanes-ptdcho-ip-by-peripheral-human-group-iia-v-and-x-secretory-phospholipases-a2-spla2
#18
Arnis Kuksis, Waldemar Pruzanski
Biologically active F- and E/D-type-prostane ring isomers (F2-IP and E2/D2-IP, respectively) are produced in situ by non-enzymatic peroxidation of arachidonic acid esterified to GroPCho (PtdCho-IP) and are universally distributed in tissue lipoproteins and cell membranes. Previous work has shown that platelet-activating factor acetylhydrolases (PAF-AH) are the main endogenous PLA2 involved in degradation of PtdCho-IP. The present study shows that the PtdCho-IP are also subject to hydrolysis by group IIA, V and X secretory PLA2, which also have a wide peripheral tissue distribution...
May 20, 2017: Lipids
https://www.readbyqxmd.com/read/28527890/mechano-electric-coupling-heterogeneity-in-repolarization-and-the-electrocardiographic-t-wave
#19
REVIEW
V M F Meijborg, C N W Belterman Va, J M T de Bakker, R Coronel, C E Conrath
Stretch influences repolarization by mechano-electric coupling (MEC) and contributes to arrhythmogenesis. Although there is an abundance of research on electrophysiological effects of MEC, it is still unclear how MEC translates to the ECG. We aim to provide an overview of the MEC research focused on the ECG and the underlying changes in electrophysiology. In addition, we present new data on the effect of left ventricular pressure on the electrocardiographic T-wave. We show that an increase in left ventricular pressure leads to prolonged QT-intervals with increased amplitudes of the STT-segment...
May 17, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28527723/activation-of-nrf2-signaling-augments-vesicular-stomatitis-virus-oncolysis-via-autophagy-driven-suppression-of-antiviral-immunity
#20
David Olagnier, Rassin R Lababidi, Samar Bel Hadj, Alexandre Sze, Yiliu Liu, Sharadha Dayalan Naidu, Matteo Ferrari, Yuan Jiang, Cindy Chiang, Vladimir Beljanski, Marie-Line Goulet, Elena V Knatko, Albena T Dinkova-Kostova, John Hiscott, Rongtuan Lin
Oncolytic viruses (OVs) offer a promising therapeutic approach to treat multiple types of cancer. In this study, we show that the manipulation of the antioxidant network via transcription factor Nrf2 augments vesicular stomatitis virus Δ51 (VSVΔ51) replication and sensitizes cancer cells to viral oncolysis. Activation of Nrf2 signaling by the antioxidant compound sulforaphane (SFN) leads to enhanced VSVΔ51 spread in OV-resistant cancer cells and improves the therapeutic outcome in different murine syngeneic and xenograft tumor models...
May 17, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
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