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https://www.readbyqxmd.com/read/29475162/the-evaluation-of-arsenic-contamination-potential-speciation-and-hydrogeochemical-behaviour-in-aquifers-of-punjab-pakistan
#1
Muhammad Bilal Shakoor, Irshad Bibi, Nabeel Khan Niazi, Muhammad Shahid, Muhammad Farrakh Nawaz, Abida Farooqi, Ravi Naidu, Mohammad Mahmudur Rahman, Ghulam Murtaza, Andreas Lüttge
In this study, we tested 123 groundwater wells from five different areas of Punjab, Pakistan for arsenic (As) contamination level and species, as well as delineated hydrogeochemical behaviour of As in aquifers. Results revealed that 75% and 41% of the groundwater wells exceeded the safe As limit of World Health Organisation (WHO, 10 μg L-1 ) and Pakistan-EPA (50 μg L-1 ), respectively. Arsenite (As(III)) and arsenate (As(V)) spanned 0-80% and 20-100% of total As (1.2-206 μg L-1 ), respectively...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29475160/immunotoxicity-of-ochratoxin-a-and-aflatoxin-b1-in-combination-is-associated-with-the-nuclear-factor-kappa-b-signaling-pathway-in-3d4-21-cells
#2
Lili Hou, Fang Gan, Xuan Zhou, Yajiao Zhou, Gang Qian, Zixuan Liu, Kehe Huang
The co-contamination of cereals, grains, crops, and animal feeds by mycotoxins is a universal problem. Humans and animals are exposed to several mycotoxins simultaneously as evidenced by extensive studies on this topic. Yet, most studies have addressed the effects of mycotoxins individually. Aflatoxin B1 and ochratoxin A can induce immunotoxicity. However, it remains unclear whether a combination of these mycotoxins aggravates immunotoxicity and the potential mechanism underlying this effect. In this study, we used the cell line 3D4/21, swine alveolus macrophages and innate immune cell...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29475102/predictors-of-benzodiazepine-use-in-a-transdiagnostic-sample-of-panic-disorder-social-anxiety-disorder-and-obsessive-compulsive-disorder-patients
#3
Luana D Laurito, Carla P Loureiro, Rafaela V Dias, Paula Vigne, Gabriela B de Menezes, Rafael C Freire, Ulrich Stangier, Leonardo F Fontenelle
We investigated the rates of current and past benzodiazepine (BZD) use in a sample of 102 subjects attending specialized anxiety disorder clinics, including panic disorder (PD; N = 36), social anxiety disorder (SAD; N = 28) and obsessive-compulsive disorder (OCD; N = 38) patients. Almost 56% of the entire sample was using BZDs at the moment of the assessment, and 74.5% described having used them at some point during their lifetimes. The duration of psychiatric treatment and a lifetime history of PD, but not any other "transdiagnostic" measure of severity (such as the Panic and Agoraphobia Scale, the Social Phobia Inventory, the Dimensional Obsessive-Compulsive Scale, the Anxiety Sensitivity Index-36, and the Beck Inventories) were independent risk factors for current prescription of BZDs...
February 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#4
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474850/lack-of-interest-in-physical-activity-individual-and-environmental-attributes-in-adults-across-europe-the-spotlight-project
#5
Eliana V Carraça, Joreintje D Mackenbach, Jeroen Lakerveld, Harry Rutter, Jean-Michel Oppert, Ilse De Bourdeaudhuij, Sofie Compernolle, Célina Roda, Helga Bardos, Pedro J Teixeira
A considerable proportion of European adults report little or no interest in physical activity. Identifying individual-level and environmental-level characteristics of these individuals can help designing effective interventions and policies to promote physical activity. This cross-sectional study additionally explored associations between level of interest and physical activity, after controlling for other individual and environmental variables. Measures of objective and perceived features of the physical environment of residence, self-reported physical activity and other lifestyle behaviors, barriers towards physical activity, general health, and demographics were obtained from 5205 European adults participating in the 2014 online SPOTLIGHT survey...
February 20, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29474479/exclusive-breastfeeding-promotion-and-neuropsychological-outcomes-in-5-8-year-old-children-from-uganda-and-burkina-faso-results-from-the-promise-ebf-cluster-randomized-trial
#6
James K Tumwine, Victoria Nankabirwa, Hama Abdoulaye Diallo, Ingunn Marie Stadskleiv Engebretsen, Grace Ndeezi, Paul Bangirana, Anselme Simeon Sanou, Espérance Kashala-Abotnes, Michael Boivin, Bruno Giordani, Irene Bircow Elgen, Penny Holding, Angelina Kakooza-Mwesige, Vilde Skylstad, Joyce Nalugya, Thorkild Tylleskar, Nicolas Meda
BACKGROUND: The beneficial effects from exclusive breastfeeding (EBF) have been widely acknowledged. We assessed the effect of exclusive breastfeeding promotion by peer counsellors in Uganda and Burkina Faso, on cognitive abilities, social emotional development, school performance and linear growth among 5-8 years old children. METHODS: Children in the PROMISE EBF trial (2006-2008) were re-enrolled in the follow-up PROMISE Saving Brains (SB) study (2013-2015). Caretaker interviews captured sociodemographic characteristics and social emotional development using the parent version of the Strengths and Difficulties Questionnaire (SDQ)...
2018: PloS One
https://www.readbyqxmd.com/read/29474406/the-role-of-the-folate-pathway-in-pancreatic-cancer-risk
#7
Shirisha Chittiboyina, Zhongxue Chen, E Gabriela Chiorean, Lisa M Kamendulis, Barbara A Hocevar
BACKGROUND: Pancreatic cancer is the third leading cause of cancer related deaths in the United States. Several dietary factors have been identified that modify pancreatic cancer risk, including low folate levels. In addition to nutrition and lifestyle determinants, folate status may be influenced by genetic factors such as single nucleotide polymorphisms (SNPs). In the present study, we investigated the association between folate levels, genetic polymorphisms in genes of the folate pathway, and pancreatic cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29474076/the-role-of-semi-labile-oxygen-atoms-for-intercalation-chemistry-of-the-metal-ion-battery-polyanion-cathodes
#8
Ivan V Tereshchenko, Dmitry A Aksyonov, Oleg A Drozhzhin, Igor A Presniakov, Alexey V Sobolev, Andriy Zhugayevych, Daniil Striukov, Keith J Stevenson, Evgeny Antipov, Artem M Abakumov
Using the orthorhombic layered Na2FePO4F cathode material as a model system we identify the bonding of the alkali metal cations to the semi-labile oxygen atoms as an important factor affecting electrochemical activity of alkali cations in the polyanion structures. The semi-labile oxygens, bonded to the P and alkali cations, but not included into the FeO4F2 octahedra, experience severe undercoordination upon alkali cation deintercalation, causing an energy penalty for removing the alkali cations located in the proximity of such semi-labile oxygens...
February 23, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29473670/some-assembly-required-contributions-of-tom-stevens-lab-to-the-v-atpase-field
#9
Laurie A Graham, Gregory C Finnigan, Patricia M Kane
Tom Stevens' lab has explored the subunit composition and assembly of the yeast V-ATPase for more than 30 years. Early studies helped establish yeast as the predominant model system for study of V-ATPase proton pumps and led to the discovery of protein splicing of the V-ATPase catalytic subunit. The Vma- phenotype, characteristic of loss of V-ATPase activity in yeast was key in determining the enzyme's subunit composition via yeast genetics. V-ATPase subunit composition proved to be highly conserved among eukaryotes...
February 23, 2018: Traffic
https://www.readbyqxmd.com/read/29473322/a-method-to-identify-the-areas-at-risk-for-the-introduction-of-avian-influenza-virus-into-poultry-flocks-through-direct-contact-with-wild-ducks
#10
G Galletti, A Santi, V Guberti, G Paternoster, E Licata, L Loli Piccolomini, A Procopio, M Tamba
Wild dabbling ducks are the main reservoir for avian influenza (AI) viruses and pose an ongoing threat to commercial poultry flocks. Combining the (i) size of that population, (ii) their flight distances and (iii) their AI prevalence, the density of AI-infected dabbling ducks (DID) was calculated as a risk factor for the introduction of AI viruses into poultry holdings of Emilia-Romagna region, Northern Italy. Data on 747 poultry holdings and on 39 AI primary outbreaks notified in Emilia-Romagna between 2000 and 2017 were used to validate that risk factor...
February 22, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29473153/serum-insulin-like-growth-factor-i-and-insulin-like-growth-factor-binding-protein-3-in-relation-to-terminal-duct-lobular-unit-involution-of-the-normal-breast-in-caucasian-and-african-american-women-the-susan-g-komen-tissue-bank
#11
Hannah Oh, Ruth M Pfeiffer, Roni T Falk, Hisani N Horne, Jackie Xiang, Michael Pollak, Louise A Brinton, Anna Maria V Storniolo, Mark E Sherman, Gretchen L Gierach, Jonine D Figueroa
Lesser degrees of terminal duct lobular unit (TDLU) involution, as reflected by higher numbers of TDLUs and acini/TDLU, are associated with elevated breast cancer risk. In rodent models, the insulin-like growth factor (IGF) system regulates involution of the mammary gland. We examined associations of circulating IGF measures with TDLU involution in normal breast tissues among women without precancerous lesions. Among 715 Caucasian and 283 African American (AA) women who donated normal breast tissue samples to the Komen Tissue Bank between 2009 to 2012 (75% premenopausal), serum concentrations of IGF-I and binding protein (IGFBP)-3 were quantified using enzyme-linked immunosorbent assay...
February 22, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29472921/kinetics-of-hiv-specific-ctl-responses-plays-a-minimal-role-in-determining-hiv-escape-dynamics
#12
Yiding Yang, Vitaly V Ganusov
Cytotoxic T lymphocytes (CTLs) have been suggested to play an important role in controlling human immunodeficiency virus (HIV-1 or simply HIV) infection. HIV, due to its high mutation rate, can evade recognition of T cell responses by generating escape variants that cannot be recognized by HIV-specific CTLs. Although HIV escape from CTL responses has been well documented, factors contributing to the timing and the rate of viral escape from T cells have not been fully elucidated. Fitness costs associated with escape and magnitude of the epitope-specific T cell response are generally considered to be the key in determining timing of HIV escape...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472910/exploring-the-genomic-traits-of-non-toxigenic-vibrio-parahaemolyticus-strains-isolated-in-southern-chile
#13
Daniel Castillo, Diliana Pérez-Reytor, Nicolás Plaza, Sebastián Ramírez-Araya, Carlos J Blondel, Gino Corsini, Roberto Bastías, David E Loyola, Víctor Jaña, Leonardo Pavez, Katherine García
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis worldwide. As reported in other countries, after the rise and fall of the pandemic strain in Chile, other post-pandemic strains have been associated with clinical cases, including strains lacking the major toxins TDH and TRH. Since the presence or absence of tdh and trh genes has been used for diagnostic purposes and as a proxy of the virulence of V. parahaemolyticus isolates, the understanding of virulence in V. parahaemolyticus strains lacking toxins is essential to detect these strains present in water and marine products to avoid possible food-borne infection...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29472685/pharmacology-mronj-risk-factor
#14
D Patel, V Patel
No abstract text is available yet for this article.
February 23, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29472587/association-of-brca1-ercc1-rap80-pkm2-rrm1-rrm2-ts-tsp1-and-txr1-mrna-expression-levels-between-primary-tumors-and-infiltrated-regional-lymph-nodes-in-patients-with-resectable-non-small-cell-lung-cancer
#15
K Tryfonidis, C Papadaki, S Assele, E Lagoudaki, J Menis, A Koutsopoulos, M Trypaki, E Tsakalaki, M Sfakianaki, B Hasan, E Stathopoulos, V Georgoulias, J Souglakos
Differences in gene expression levels between the primary tumors (PTs) and matched regional lymph nodal metastases (LNs) in patients with totally excised non-small cell lung cancer (NSCLC) were explored. Microdissected formalin-fixed paraffin-embedded (FFPE) samples from (PT) and their matched infiltrated LNs, from 239 patients [183 (with matched PT and LNs samples)-case and 56 PT only samples-control cohorts] were analyzed for BRCA1, ERCC1, RAP80, PKM2, RRM1, RRM2, TS, TSP1, and TXR1 mRNA expression by quantitative real-time polymerase-chain reaction (PCR)...
February 22, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29472075/a-novel-high-resolution-2d-silicon-array-detector-for-small-field-dosimetry-with-fff-photon-beams
#16
G Biasi, M Petasecca, S Guatelli, N Hardcastle, M Carolan, V Perevertaylo, T Kron, A B Rosenfeld
PURPOSE: Flattening filter free (FFF) beams are increasingly being considered for stereotactic radiotherapy (SRT). For the first time, the performance of a monolithic silicon array detector under 6 and 10 MV FFF beams was evaluated. The dosimeter, named "Octa" and designed by the Centre for Medical Radiation Physics (CMRP), was tested also under flattened beams for comparison. METHODS: Output factors (OFs), percentage depth-dose (PDD), dose profiles (DPs) and dose per pulse (DPP) dependence were investigated...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29471911/the-neuro-endocrine-immune-relationship-in-pulmonary-and-pleural-tuberculosis-a-better-local-profile-in-pleural-fluid
#17
L D'Attilio, A Díaz, R D V Fernández, B Bongiovanni, N Santucci, G Dídoli, S Lioi, W Gardeñez, J L Naninni, A Del Rey, H Besedovsky, O Bottasso, M L Bay
BACKGROUND: Tuberculosis (TB) is a major health problem worldwide. In TB, the immune and central nervous systems modulate each other. The two main components of this network are the hypothalamic-pituitary-adrenal axis (HPA) and autonomic nervous system (ANS). OBJECTIVE: To elucidate neuro-endocrine-immune (NEI) interactions in pulmonary (PTB) or pleural (PLTB) TB, we analysed the relationship among compounds from these systems. METHODS: We quantified levels of catecholamines, hormones and cytokines in plasma from patients with PTB (n = 46) or PLTB (n = 12) and controls (n = 32), and in the pleural fluid from PLTB patients...
March 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29471444/relation-of-sex-hormone-levels-with-prevalent-and-10-year-change-in-aortic-distensibility-assessed-by-mri-the-multi-ethnic-study-of-atherosclerosis
#18
V Subramanya, B Ambale-Venkatesh, Y Ohyama, D Zhao, C C Nwabuo, W S Post, E Guallar, P Ouyang, S J Shah, M A Allison, C E Ndumele, D Vaidya, D A Bluemke, J A Lima, E D Michos
Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 post-menopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline...
February 19, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29470977/the-unfolded-protein-response-in-ischemic-heart-disease
#19
REVIEW
Xiaoding Wang, Lin Xu, Thomas G Gillette, Xuejun Jiang, Zhao V Wang
Ischemic heart disease is a severe stress condition that causes extensive pathological alterations and triggers cardiac cell death. Accumulating evidence suggests that the unfolded protein response (UPR) is strongly induced by myocardial ischemia. The UPR is an evolutionarily conserved cellular response to cope with protein-folding stress, from yeast to mammals. Endoplasmic reticulum (ER) transmembrane sensors detect the accumulation of unfolded proteins and stimulate a signaling network to accommodate unfolded and misfolded proteins...
February 19, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29470838/first-line-cetuximab-monotherapy-in-kras-nras-braf-mutation-negative-colorectal-cancer-patients
#20
Vladimir M Moiseyenko, Fedor V Moiseyenko, Grigoriy A Yanus, Ekatherina Sh Kuligina, Anna P Sokolenko, Ilya V Bizin, Alexey A Kudriavtsev, Svetlana N Aleksakhina, Nikita M Volkov, Vyacheslav A Chubenko, Kseniya S Kozyreva, Mikhail M Kramchaninov, Alexandr S Zhuravlev, Kseniya V Shelekhova, Denis V Pashkov, Alexandr O Ivantsov, Aigul R Venina, Tatyana N Sokolova, Elena V Preobrazhenskaya, Natalia V Mitiushkina, Alexandr V Togo, Aglaya G Iyevleva, Evgeny N Imyanitov
BACKGROUND: Colorectal carcinomas (CRCs) are sensitive to treatment by anti-epidermal growth factor receptor (EGFR) antibodies only if they do not carry activating mutations in down-stream EGFR targets (KRAS/NRAS/BRAF). Most clinical trials for chemo-naive CRC patients involved combination of targeted agents and chemotherapy, while single-agent cetuximab or panitumumab studies included either heavily pretreated patients or subjects who were not selected on the basis of molecular tests...
February 22, 2018: Clinical Drug Investigation
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