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JOURNAL ARTICLE
Tsegaye Atrese, Lata Fekadu, Guta Kune, Abel Shita, Kifle Woldemikael
BACKGROUND: Diabetes mellitus continues to be a significant global public health concern, and it is currently a public health issue in developing nations. In Ethiopia, about three fourth of adult population with diabetes are unaware of their diabetic condition. However, there is a limited research on this specific topic particularly in the study area. OBJECTIVE: To assess prevalence of undiagnosed diabetes mellitus and its associated factor among adult residents of Mizan Aman town, south West Ethiopia...
2024: PloS One
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JOURNAL ARTICLE
Helene M Flatby, Anuradha Ravi, Kristin V Liyanarachi, Jan E Afset, Humaira Rasheed, Ben M Brumpton, Kristian Hveem, Bjørn O Åsvold, Andrew T DeWan, Erik Solligård, Jan K Damås, Tormod Rogne
BACKGROUND: Our goal was to identify genetic and modifiable risk factors for upper urinary tract infections (UTIs). METHODS: We used data from UK Biobank, The Trøndelag Health Study (HUNT), and Michigan Genomics Initiative (MGI) to conduct genome-wide association studies (GWASs) and sex-stratified analyses on upper UTI. Mendelian randomization (MR) analyses were conducted to examine potential causal relationships between cardiometabolic risk factors and upper UTIs...
May 7, 2024: Journal of Infectious Diseases
#3
JOURNAL ARTICLE
Solomon Owumi, Harieme Agbarogi, Bayode J Oluwawibe, Moses T Otunla, Mayowa M Anifowose, Uche O Arunsi
Sodium fluoride (NaF) ingestion has several detrimental effects in humans and rodents. NaF mechanisms of toxicity include perturbation of intracellular redox homeostasis and apoptosis. Betaine (BET) is a modified amino acid with anti-inflammatory, antioxidant, and anti-apoptotic properties. This study investigates BET's effect on NaF-induced hepatorenal toxicities in rats. Experimental rats (n = 30) were randomly assigned to groups (n = 6) and treated by gavage for 28 days. Group I (2 mL of distilled water), Group II (NaF: 9 mg/kg) alone, Group III: (BET: 100 mg/kg), Group IV: (NaF: 9 mg/kg and BET 1: 50 mg/kg), and Group V: (NaF: 9 mg/kg and BET 2: 100 mg/kg)...
May 7, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#4
JOURNAL ARTICLE
O A Gromova, M V Filimonova, I Y Torshin, D Е Frolova
AIM: To investigate the antitumor effects of human placenta hydrolysate (HPH) peptides on three hormone-dependent human cell lines: prostate adenocarcinoma, breast carcinoma, and ovarian cancer by metabolic analysis of cell cultures. MATERIALS AND METHODS: The effect of HPH on tumor and control tumor cell lines was evaluated. Study stages: (A) de novo peptide sequencing by collision-induced dissociation mass spectrometry; (B) detection of peptides with anti-tumor properties; (C) expert analysis of the obtained lists of peptides...
April 16, 2024: Terapevticheskiĭ Arkhiv
#5
JOURNAL ARTICLE
Saneela Mahtab, Aisha Nazir, Muhammad Shafiq
From tannery effluent (TE) severely polluted with heavy metals (HMs viz., Cr, Cu, Cd, and Pb), hydrophytic phytoextraction remains a challenge as transplanted plants succumb to death on facing acclimatization shock. Current study was aimed at diluting TE with harvested rainwater (HR) for improving HM phytoextraction potential of Phragmites australis (a hydrophyte) assisted with phycoremediation of coupled algae (viz., Oedogonium sp. and Pithophora sp.). The TE:HR dilutions (TEDs) 0, 25, 50, 75, and 100% ( v/v ) included three sets: set-1 included algae only, set-2 included P...
May 7, 2024: International Journal of Phytoremediation
#6
JOURNAL ARTICLE
Sedighe Esmaeilzadeh, Omid Jazayeri, Mir Mohammad Reza Aghajani, Shima Soleimani Amiri, Masoumeh GolsorkhtabarAmiri, Maryam Abdolahzade Delavar, Parvaneh Mirabi
OBJECTIVE: Many pieces of literature have reported that inherited and acquired thrombophilia might be a risk factor for recurrent implantation failure (RIF), however, most studies have only focused on RIF patients and not their male partners. We studied the possible association of paternal thrombophilia with RIF risk. METHODS: Forty-two male partners aged 20-45 suffered from RIF compared with 42 males from couples with at least one successful pregnancy. All participants were investigated for thrombophilia markers...
May 7, 2024: JBRA Assisted Reproduction
#7
JOURNAL ARTICLE
Basant E Katamesh, Alicia A Mickow, Linda Huang, Brian M Dougan, Basem M Ratrout, Sanjeev Nanda, Ann Vincent
Statin therapy is a cornerstone in the management of dyslipidemia, both in primary and secondary prevention of cardiovascular events. Despite strong guidelines supporting statin use, concerns regarding side effects, particularly musculoskeletal symptoms, contribute to statin intolerance and patient reluctance. While statin intolerance is reported in 5% to 30% of patients, its true prevalence may be overestimated due to the influence of the nocebo effect. Factors associated with higher incidence of statin intolerance include older age, female gender, comorbidities such as diabetes and chronic kidney disease, and concurrent use of medications such as antiarrhythmic agents or calcium channel blockers...
May 7, 2024: Kardiologia Polska
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JOURNAL ARTICLE
Xuewen Sun, Wenjuan Guo, Lu Wang, Xin Xin, Xuerong Yang, Junbao Wen
Eucryptorrhynchus scrobiculatus (Motschulsky) (Coleoptera: Curculionidae) is a notorious pest of Ailanthus altissima (Mill.) Swingle (Sapindales: Simaroubaceae). E. scrobiculatus adults typically aggregate under leaves and in soil crevices at the base of A. altissima in the field. We hypothesize that the environmental factors and conspecific signals determine their aggregation behavior. To test this, we investigated adult numbers in light-exposed and shaded areas of the sample trees and conducted experiments in both field and lab settings...
May 7, 2024: Environmental Entomology
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JOURNAL ARTICLE
Judith M Sarneel, Mariet M Hefting, Taru Sandén, Johan van den Hoogen, Devin Routh, Bhupendra S Adhikari, Juha M Alatalo, Alla Aleksanyan, Inge H J Althuizen, Mohammed H S A Alsafran, Jeff W Atkins, Laurent Augusto, Mika Aurela, Aleksej V Azarov, Isabel C Barrio, Claus Beier, María D Bejarano, Sue E Benham, Björn Berg, Nadezhda V Bezler, Katrín Björnsdóttir, Martin A Bolinder, Michele Carbognani, Roberto Cazzolla Gatti, Stefano Chelli, Maxim V Chistotin, Casper T Christiansen, Pascal Courtois, Thomas W Crowther, Michele S Dechoum, Ika Djukic, Sarah Duddigan, Louise M Egerton-Warburton, Nicolas Fanin, Maria Fantappiè, Silvano Fares, Geraldo W Fernandes, Nina V Filippova, Andreas Fliessbach, David Fuentes, Roberto Godoy, Thomas Grünwald, Gema Guzmán, Joseph E Hawes, Yue He, Jean-Marc Hero, Laura L Hess, Katja Hogendoorn, Toke T Høye, Wilma W P Jans, Ingibjörg S Jónsdóttir, Sabina Keller, Sebastian Kepfer-Rojas, Natalya N Kuz'menko, Klaus S Larsen, Hjalmar Laudon, Jonas J Lembrechts, Junhui Li, Jean-Marc Limousin, Sergey M Lukin, Renato Marques, César Marín, Marshall D McDaniel, Qi Meek, Genrietta E Merzlaya, Anders Michelsen, Leonardo Montagnani, Peter Mueller, Rajasekaran Murugan, Isla H Myers-Smith, Stefanie Nolte, Raúl Ochoa-Hueso, Bernard N Okafor, Vladimir V Okorkov, Vladimir G Onipchenko, María C Orozco, Tina Parkhurst, Carlos A Peres, Matteo Petit Bon, Alessandro Petraglia, Martin Pingel, Corinna Rebmann, Brett R Scheffers, Inger Schmidt, Mary C Scholes, Efrat Sheffer, Lyudmila K Shevtsova, Stuart W Smith, Adriano Sofo, Pablo R Stevenson, Barbora Strouhalová, Anders Sundsdal, Rafael B Sühs, Gebretsadik Tamene, Haydn J D Thomas, Duygu Tolunay, Marcello Tomaselli, Simon Tresch, Dominique L Tucker, Michael D Ulyshen, Alejandro Valdecantos, Vigdis Vandvik, Elena I Vanguelova, Kris Verheyen, Xuhui Wang, Laura Yahdjian, Xaris S Yumashev, Joost A Keuskamp
The breakdown of plant material fuels soil functioning and biodiversity. Currently, process understanding of global decomposition patterns and the drivers of such patterns are hampered by the lack of coherent large-scale datasets. We buried 36,000 individual litterbags (tea bags) worldwide and found an overall negative correlation between initial mass-loss rates and stabilization factors of plant-derived carbon, using the Tea Bag Index (TBI). The stabilization factor quantifies the degree to which easy-to-degrade components accumulate during early-stage decomposition (e...
May 2024: Ecology Letters
#10
JOURNAL ARTICLE
David Füller, Chang Liu, Shivang R Desai, Nishant Vatsa, Yan V Sun, Arshed A Quyyumi
BACKGROUND: A higher prevalence of cardiovascular risk factors has previously been shown to be associated with adverse social determinants of health (SDoH) and to explain some of their impact on cardiovascular risk. Whether there is a relationship between lipid parameters, specifically apolipoprotein B (apoB), apolipoprotein A1 (apoA1), their ratio (apoB/apoA1), and SDoH, and whether coronary artery disease (CAD) mortality risk associated with circulating apoB and apoA1 is modified by SDoH was unclear...
May 6, 2024: Coronary Artery Disease
#11
JOURNAL ARTICLE
Hongze Wang, Junbo Wang, Qingyun He, Jingxi Chang, Shaoyu Chen, Chongyu Zhong, Mengyang Wu, Xiangru Zhao, Haoyu Chen, Qiushuang Tian, Mubai Li, Jingya Lai, Yingguo Yang, Renzhi Li, Bo Wu, Wei Huang, Tianshi Qin, Fangfang Wang
Interfacial engineering of perovskite films has been the main strategies in improving the efficiency and stability of perovskite solar cells (PSCs). In this study, three new donor-acceptor (D-A)-type interfacial dipole (DAID) molecules with hole-transporting and different anchoring units are designed and employed in PSCs. The formation of interface dipoles by the DAID molecules on the perovskite film can efficiently modulate the energy level alignment, improve charge extraction, and reduce non-radiative recombination...
May 7, 2024: Angewandte Chemie
#12
A Balachandran, H Pei, J Beard, A Caspip, A Cohen, B W Domingue, C Eckstein Indik, L Ferrucci, A Furuya, M Kothari, T E Moffitt, C Ryan, V Skirbekk, Y Zhang, D W Belsky
As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy analysis do not distinguish differences caused by early-life factors, such as prenatal care and nutrition, from those caused by ongoing changes in people's bodies due to aging. Here we introduce an adapted Pace of Aging method designed to quantify differences between individuals and populations in the speed of aging-related health declines...
April 26, 2024: medRxiv
#13
Weicheng Zhu, Huanze Tang, Hao Zhang, Haresh Rengaraj Rajamohan, Shih-Lun Huang, Xinyue Ma, Ankush Chaudhari, Divyam Madaan, Elaf Almahmoud, Sumit Chopra, John A Dodson, Abraham A Brody, Arjun V Masurkar, Narges Razavian
Early identification of Alzheimer's disease (AD) and AD-related dementias (ADRD) has high clinical significance, both because of the potential to slow decline through initiating FDA-approved therapies and managing modifiable risk factors, and to help persons living with dementia and their families to plan before cognitive loss makes doing so challenging. However, substantial racial and ethnic disparities in early diagnosis currently lead to additional inequities in care, urging accurate and inclusive risk assessment programs...
April 27, 2024: medRxiv
#14
Wenjie Zhu, Xiaoyan Xu, Vijayaraj Nagarajan, Jing Guo, Zixuan Peng, Amy Zhang, Jie Liu, Mary J Mattapallil, Yingyos Jittayasothorn, Reiko Horai, Anthony J St Leger, Rachel R Caspi
UNLABELLED: The ocular surface is a mucosal barrier tissue colonized by commensal microbes, which tune local immunity by eliciting IL-17 from conjunctival γδ T cells to prevent pathogenic infection. The commensal Corynebacterium mastitidis ( C. mast ) elicits protective IL-17 responses from conjunctival Vγ4 T cells through a combination of γδ TCR ligation and IL-1 signaling. Here, we identify Vγ6 T cells as a major C. mast -responsive subset in the conjunctiva and uncover its unique activation requirements...
April 1, 2024: bioRxiv
#15
Erik D Nelson, Madhavi Tippani, Anthony D Ramnauth, Heena R Divecha, Ryan A Miller, Nicholas J Eagles, Elizabeth A Pattie, Sang Ho Kwon, Svitlana V Bach, Uma M Kaipa, Jianing Yao, Joel E Kleinman, Leonardo Collado-Torres, Shizhong Han, Kristen R Maynard, Thomas M Hyde, Keri Martinowich, Stephanie C Page, Stephanie C Hicks
The hippocampus contains many unique cell types, which serve the structure's specialized functions, including learning, memory and cognition. These cells have distinct spatial topography, morphology, physiology, and connectivity, highlighting the need for transcriptome-wide profiling strategies that retain cytoarchitectural organization. Here, we generated spatially-resolved transcriptomics (SRT) and single-nucleus RNA-sequencing (snRNA-seq) data from adjacent tissue sections of the anterior human hippocampus across ten adult neurotypical donors...
April 28, 2024: bioRxiv
#16
Rebecca Schneider Aguirre, Tamara S Hannon, Robert V Considine, Yash Patel, M Sue Kirkman, Kieren J Mather
BACKGROUND AND AIMS: Identifying simple markers of risk for worsening glucose can allow care providers to target therapeutic interventions according to risk of worsening glycemic control. We aimed to determine which routine clinical measures herald near-term glycemic worsening in early type 2 diabetes(T2D). METHODS: The Early Diabetes Intervention Program (EDIP) was a clinical trial in individuals with screen-detected T2D [HbA1C 6.3+0.63%(45+5mmol/mol)]. During the trial some participants experienced worsening fasting blood glucose (FBG)...
April 27, 2024: medRxiv
#17
Kondalarao Bankapalli, Ruth E Thomas, Evelyn S Vincow, Gillian Milstein, Laura V Fisher, Leo J Pallanck
UNLABELLED: Brain protein aggregates are a hallmark of neurodegenerative disease. Previous work indicates that specific protein components of these aggregates are toxic, including tau in Alzheimer's disease and related tauopathies. Increasing evidence also indicates that these toxic proteins traffic between cells in a prion-like fashion, thereby spreading pathology from one brain region to another. However, the mechanisms involved in trafficking are poorly understood. We therefore developed a transgenic Drosophila model to facilitate rapid evaluation of candidate tau trafficking modifiers...
April 25, 2024: bioRxiv
#18
Ruiying Wang, Lorena V N Oliveira, Maureen M Hester, Diana Carlson, Dennis Christensen, Charles A Specht, Stuart M Levitz
UNLABELLED: The fungal infection, cryptococcosis, is responsible for >100,000 deaths annually. No licensed vaccines are available. We explored the efficacy and immune responses of subunit cryptococcal vaccines adjuvanted with Cationic Adjuvant Formulation 01 (CAF01). CAF01 promotes humoral and T helper (Th) 1 and Th17 immune responses and has been safely used in human vaccine trials. Four subcutaneous vaccines, each containing single recombinant Cryptococcus neoformans protein antigens, partially protected mice from experimental cryptococcosis...
April 28, 2024: bioRxiv
#19
Samara V Silver, Kayah J Tucker, Renee E Vickman, Nadia A Lanman, O John Semmes, Nehemiah S Alvarez, Petra Popovics
Benign prostatic hyperplasia (BPH) is a prevalent age-related condition often characterized by debilitating urinary symptoms. Its etiology is believed to stem from hormonal imbalance, particularly an elevated estradiol-to-testosterone ratio and chronic inflammation. Our previous studies using a mouse steroid hormone imbalance model identified a specific increase in macrophages that migrate and accumulate in the prostate lumen where they differentiate into lipid-laden foam cells in mice implanted with testosterone and estradiol pellets, but not in sham animals...
April 28, 2024: bioRxiv
#20
JOURNAL ARTICLE
Jiwon Oh, Paul S Giacomini, V Wee Yong, Fiona Costello, François Blanchette, Mark S Freedman
Significant advances have been made in the diagnosis and treatment of multiple sclerosis in recent years yet challenges remain. The current classification of MS phenotypes according to disease activity and progression, for example, does not adequately reflect the underlying pathophysiological mechanisms that may be acting in an individual with MS at different time points. Thus, there is a need for clinicians to transition to a management approach based on the underlying pathophysiological mechanisms that drive disability in MS...
2024: Journal of Central Nervous System Disease
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