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liver function test in post partum period

Catherine Brumby, Irena Idel, Rebecca Still, Lee Skeat, Lawrence P McMahon
OBJECTIVES: Disorders associated with marked liver dysfunction in late pregnancy include pre-eclampsia, HELLP syndrome, obstetric cholestasis, and acute fatty liver of pregnancy. Accurate diagnosis and appropriate timing of delivery are required in these conditions to minimize risk of maternal and fetal morbidity/mortality. We report a case series of women with significant and persistent liver dysfunction (>3-fold rise = ALT >90 IU/L) in the third trimester, where a definitive diagnosis remained obscure using accepted diagnostic tools for these and other liver conditions...
January 2015: Pregnancy Hypertension
Sananta Kumar Dash, Munish Chauhan, Vishakh Varma, Rakesh Sharma, Sudha Kansal, Rajesh Chawla
Urea cycle disorders (UCD) are common during neonatal period, and it is rarely reported in adults. We are reporting a patient presenting with post-partum neuropsychiatric symptoms rapidly progressing to coma. Markedly raised serum ammonia level on presentation with an initial normal magnetic resonance imaging (MRI) of brain and normal liver function tests led to the suspicion of UCD, which was confirmed on the basis of urine orotic acid and elevated serum amino acid levels. We had to resort to hemodialysis to correct the hyperammonemic coma, which was unresponsive to conventional anti-ammonia measures...
March 2013: Indian Journal of Critical Care Medicine
S F M Häusler, T Bernar, S Rau, P Kranke, J Dietl, L Rieger
BACKGROUND: A severe hepatopathy constitutes a serious threat during pregnancy and poses considerable challenges to the treating physicians. A broad spectrum of pregnancy-dependent or independent diseases like HELLP-syndrome, liver infection or acute fatty liver of pregnancy (AFLP) is characterized by these affections of the liver. In this study, we present a series of 3 cases with life-threatening hepatopathies and discuss the current state of the literature. A special focus is placed on pathogenesis and differential diagnosis...
December 2012: Zeitschrift Für Geburtshilfe und Neonatologie
Ranmali Waduge, G N Malavige, M Pradeepan, Chandrika N Wijeyaratne, Sirimali Fernando, Suranjith L Seneviratne
BACKGROUND: Dengue is a major public health problem in several countries. Few reports document presentations and outcomes of dengue during pregnancy. In many endemic countries as the average age of getting dengue infections is shifting upwards, dengue in pregnancy is likely to be encountered more frequently. Patterns of dengue in patients from different regions are needed if we are to draft evidence based management guidelines. OBJECTIVES: To document clinical and laboratory findings in a cohort of hospitalised patients with dengue during pregnancy in Sri Lanka and compare their presentation and outcomes with previously published cases...
September 2006: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Manfred Fürll, Frank Jäckel
Effects of glucocorticoids on lipid metabolism, hepatic metabolism, haematological parameters and milk yield in high-yielding cows in the early stages of lactation. The assumption is widespread that glucocorticoids promote lipolysis and fatty liver in ruminants. But there are contrary experimental results. Therefore we investigated the effects of dexamethasone (in the form of Voren suspension) in cows with very high milk yields (herd average 10.000 kg/year) between 7 and 15 days post partum, when high levels of lipolysis occur...
May 2005: Berliner und Münchener Tierärztliche Wochenschrift
Douglas Samuel, Stephen Riordan, Simone Strasser, Jelica Kurtovic, Indira Singh-Grewel, David Koorey
BACKGROUND & AIMS: Autoimmune hepatitis (AIH) may run an aggressive clinical course if untreated. The influence of pregnancy on AIH is variable. Both flares in disease activity and remissions, often followed by a post partum flare, are well recognized. In contrast, definite AIH first presenting in the early post partum period has not been reported. METHODS: We discuss a case series of 5 patients who developed severe AIH within 4 months post partum. RESULTS: The diagnosis of AIH was definite based on internationally accepted criteria...
July 2004: Clinical Gastroenterology and Hepatology
S M Khedun, T Naicker, J Moodley
BACKGROUND: To improve the diagnostic accuracy of concurrent renal disease in hypertension of pregnancy, biopsy evaluation is essential. In addition, establishing underlying renal disease is important for prognosis on future pregnancies. We therefore designed a study to determine the diagnostic yield of postpartum renal biopsy and the nature and frequency of complications associated with this procedure. Also, to determine relationships, if any, between renal function tests and ultrastructural and histopathological findings...
May 2000: Acta Obstetricia et Gynecologica Scandinavica
F Dabis, P Msellati, N Meda, C Welffens-Ekra, B You, O Manigart, V Leroy, A Simonon, M Cartoux, P Combe, A Ouangré, R Ramon, O Ky-Zerbo, C Montcho, R Salamon, C Rouzioux, P Van de Perre, L Mandelbrot
BACKGROUND: Zidovudine reduces the rate of vertical transmission of HIV in non-breastfed populations. We assessed the acceptability, tolerance, and 6-month efficacy of a short regimen of oral zidovudine in African populations practising breastfeeding. METHODS: A randomised double-blind placebo-controlled trial was carried out in public clinics of Abidjan, Côte d'Ivoire, and Bobo-Dioulasso, Burkina Faso. Eligible participants were women aged 18 years or older, who had confirmed HIV-1 infection and pregnancy of 36-38 weeks duration, and who gave written informed consent...
March 6, 1999: Lancet
M Fürll, B Fürll
Starting on the 7th day post partum, 200 mg prednisolone were given daily to four healthy cows over a period of five days in order to examine how fat metabolism and liver function were influenced. Samples of blood and urine were taken daily as well as liver biopsies on the third and fifth day. These findings in the cows of the experimental group were compared to those in the four untreated cows (control group). Prednisolone induced a significant increase in glucose and insulin serum concentrations and a decrease of FFA and bilirubin concentrations as well as lipid and rising glycogen concentrations in the liver...
September 1998: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
(no author information available yet)
OBJECTIVE: To improve efficacy of and compliance with therapy for tuberculosis in children. OPTIONS: Short-course (6-month) multi-drug therapy, either non-supervised or directly supervised, versus long-course (more than 6-month) multi-drug therapy. OUTCOMES: Success (more than 90% of cases cured without relapse or serious side effects), development of drug resistance and compliance with treatment. EVIDENCE: Review of published reports of efficacy trials of tuberculosis therapy in children, side effects and compliance studies; consensus of expert opinion...
April 15, 1994: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
A M van den Top, A T van 't Klooster, T Wensing, G H Wentink, A C Beynen
The hypothesis was tested that goats allowed ad libitum access to feed during the dry period develop higher post partum hepatic triacylglycerol concentrations than do goats given a restricted amount of feed during the dry period. Goats in their second or more pregnancies were either given a restricted amount of hay, maize silage and concentrate (n = 5) or had free access to this feed mixture while the composition was kept constant (n = 11). After parturition both groups were allowed ad libitum access to feed...
June 1995: Veterinary Quarterly
J Heikkinen, O Mäentausta, P Ylöstalo, O Jänne
Two primary bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA), and one secondary bile acid, deoxycholic acid (DCA), were measured by radioimmunoassay in pregnancy serum from 30 healthy women, 49 women with itching and 45 with intrahepatic cholestasis of pregnancy. All subjects were studied serially from between 16 and 20 weeks gestation until 35-60 days post partum. In healthy pregnant women, serum CA and DCA levels did not change significantly at any time. The mean CDCA level rose significantly towards term...
March 1981: British Journal of Obstetrics and Gynaecology
M A Arreola Salinas, M A Quiroga Cantú, R García Contreras
The present work includes six cases of congenital syphilis that were diagnosed radiologically before birth in patients with positive syphilitic reactions who had not been given treatment during gestation. The x-ray diagnosis was mainly based on lesions of diaphyses and metaphyses of the long bones of the fetal skeleton that were identified in lateral projection of x-ray plates of the maternal abdomen. In all cases reported, x-ray plates were taken in the immediate post-partum period with confirmation of the bony lesions and at the same time, of the laboratory tests including blood picture and liver function test in 5 cases...
January 1980: Boletín Médico del Hospital Infantil de México
H Rudolf, G Göretzlehner, E Brügmann, J Töwe, K Rudolf
Indocyaningreen (ICG) was given for the characterize of the excretion function of the liver during the course of normal pregnancy, sub partu and post partum. Studies were performed in 168 primi- and multigravidas with normal medical and obstetric histories (mean age of 23,5 years). 0,5 mg ICG/kg body mass were injected intravenously as a bolus. 18 healthy nonpregnant women served as controls (mean age of 24,2 years). In the I. and II. trimester of pregnancy the elimination of ICG was not decreased in comparison to the controls (3,64 +/- 0,86)...
1977: Zentralblatt Für Gynäkologie
B E Dahlgren
Blood urea content and the serum concentrations of sodium, creatinine, uric acid, glutamic oxaloacetic transaminase (g.o.t.), glutamic pyruvate transaminase (g.p.t.) and bilirubin were measured before delivery, on the 2nd and 3rd days and on the 5th day after delivery. In two groups of mothers, one receiving nitrous oxide analgesia and the other a combination of nitrous oxide and methoxyflurane, blood urea and serum sodium and g.o.t. were increased following labour and nitrous oxide analgesia; s.g.p.t. was increased only in the late post-partum period...
December 1977: British Journal of Anaesthesia
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