Chang Liu, Molly Tzu-Yu Lin, Isabelle Xin Yu Lee, Jipson Hon Fai Wong, Daqian Lu, Thomas Chuen Lam, Lei Zhou, Jodhbir S Mehta, Hon Shing Ong, Marcus Ang, Louis Tong, Yu-Chi Liu
PURPOSE: To investigate the tear proteomic and neuromediator profiles, in vivo confocal microscopy (IVCM) imaging features, and clinical manifestations in neuropathic corneal pain (NCP) patients. DESIGN: Cross-sectional study. METHODS: Twenty NCP patients and twenty age-matched controls were recruited. All subjects were evaluated by corneal sensitivity, Schirmer's test, tear break-up time, corneal and ocular surface staining, Ocular Surface Disease Index and Ocular Pain Assessment Survey questionnaires, as well as IVCM examinations for corneal nerves, microneruomas, epithelial and dendritic cells...
March 21, 2024: American Journal of Ophthalmology