keyword
https://read.qxmd.com/read/38545006/clinical-significance-of-the-combined-test-of-seven-blood-coagulation-indexes-lipids-and-platelet-agglutination-on-hypercoagulable-state-of-blood-in-parturient-women
#1
JOURNAL ARTICLE
Wenjuan Zhang, Tao Yu, Yunshuang Wang, Meili Hu, Tianxiang Gao
OBJECTIVE: To investigate the value of the combined test of seven blood coagulation indexes, lipids and platelet agglutination on the evaluation of the hypercoagulable state of blood in parturient women. METHODS: This is a retrospective study. Total 50 high risk parturient women who underwent an antenatal examination in Baoding Maternal and Child Health Hospital from June 2021 to January 2023 were selected as the observation group, while 50 normal parturient women who underwent antenatal examination without comorbidities and complications were randomly collected in a ratio of 1:1 as the control group...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38535116/short-term-mortality-in-hospitalized-patients-with-congestive-heart-failure-markers-of-thrombo-inflammation-are-independent-risk-factors-and-only-weakly-associated-with-renal-insufficiency-and-co-morbidity-burden
#2
JOURNAL ARTICLE
Jose Iglesias, Nelson Okoh, Song Peng Ang, Cristina A Rodriguez, Jia Ee Chia, Jerrold S Levine
Congestive heart failure (CHF) is associated with significant morbidity and mortality. There has been renewed interest in using thrombo-inflammatory markers as prognostic tools in patients with CHF. To determine if thrombo-inflammatory markers are independent risk factors for 28-day mortality in hospitalized CHF patients, we retrospectively analyzed admission data extracted from 2008 consecutive patients admitted with a diagnosis of CHF to Zigong Fourth People's Hospital. Multivariate Cox proportional hazards analysis demonstrated that the thrombo-inflammatory markers thrombin time, platelet/lymphocyte ratio (PLR), and D-dimer level were independent predictors of mortality...
March 20, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534886/drug-drug-interactions-of-fxi-inhibitors-clinical-relevance
#3
REVIEW
Nicola Ferri, Elisa Colombo, Alberto Corsini
Inhibitors of the factor FXI represent a new class of anticoagulant agents that are facing clinical approval for the treatment of acute coronary syndrome (ACS), venous thromboembolism (VTE), and stroke prevention of atrial fibrillation (AF). These new inhibitors include chemical small molecules (asundexian and milvexian), monoclonal antibodies (abelacimab, osocimab, and xisomab), and antisense oligonucleotides (IONIS-FXIRX and fesomersen), and thus, they have very peculiar and different pharmacokinetic and pharmacodynamic properties...
March 21, 2024: Hematology Reports
https://read.qxmd.com/read/38533680/determination-of-procoagulant-activity-in-human-normal-immunoglobulin-preparations-for-therapeutic-use-by-fxia-chromogenic-assay-evaluation-of-test-kit-sensitivity-reference-standard-performance-and-product-formulation-effects-on-the-fxia-assay
#4
JOURNAL ARTICLE
M-E Behr-Gross, D Le Tallec, N Sinitskaya, C Milne, M Etscheid
In 2010, the reporting of thrombotic adverse events for one subcutaneous and certain intravenous immunoglobulins (IGs) raised some concerns. In Europe, regulatory bodies rapidly revised compendial specifications for therapeutic IGs to ensure they do not exhibit thrombogenic (procoagulant) activity (PCA). At the global level, a working group (GWG) was launched with the aim of assessing PCA measurement methods and limits, considering results obtained by human IG manufacturers during in-process controls. The GWG created three dedicated subgroups to investigate the FXIa chromogenic assay, the non-activated partial thromboplastin time (NAPTT) test and the thrombin generation assay (TGA)...
2024: Pharmeuropa Bio & Scientific Notes
https://read.qxmd.com/read/38533078/revisiting-the-effect-of-cholesteryl-sulfate-on-clotting-and-fibrinolysis-inhibition-of-human-thrombin-and-other-human-blood-proteases
#5
JOURNAL ARTICLE
Rami A Al-Horani
Cholesteryl sulfate (CS) was quantitatively synthesized by microwave-assisted sulfonation of cholesterol followed by sodium exchange chromatography. In vitro effects of CS on human thrombin and other serine proteases of the coagulation and fibrinolysis processes were investigated using a series of biochemical and biophysical techniques. CS was found to inhibit thrombin with an IC 50 value of 140.8 ± 21.8 μM at pH 7.4 and 25 ○ C. Michaelis-Menten kinetics indicated that thrombin inhibition by CS is non-competitive (allosteric) in nature...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38531825/whole-blood-storage-duration-alters-fibrinogen-levels-and-thrombin-formation
#6
JOURNAL ARTICLE
Ryan Chae, Christopher Nguyen, Chad Archdeacon, Lindsey Wattley, Stephanie Sisak, Adam Price, Emma Perez, Rebecca Schuster, Alex Lentsch, Charles Caldwell, Michael Goodman, Timothy Pritts
INTRODUCTION: Whole blood resuscitation for hemorrhagic shock in trauma represents an opportunity to correct coagulopathy in trauma while also supplying red blood cells. The production of microvesicles in stored whole blood and their effect on its hemostatic parameters have not been described in previous literature. We hypothesized that microvesicles in aged stored whole blood are procoagulant and increase thrombin production via phosphatidylserine. METHODS: Whole blood was obtained from male C57BL/6 male mice and stored in anticoagulant solution for up to 10 days...
March 27, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38531252/integrating-network-pharmacology-with-microrna-microarray-analysis-to-identify-the-role-of-mirnas-in-thrombosis-treated-by-the-dahuang-zhechong-pill
#7
JOURNAL ARTICLE
Rui Shi, Shan Gao, Huichao Huang, Ke Jiang, Dongsheng Wang
BACKGROUND: Thrombotic diseases are the leading causes of death worldwide, urging for improvements in treatment strategies. Dahuang Zhechong pill (DHZCP) is a traditional Chinese medicine widely used for treating thrombotic diseases; however, the underlying mechanisms remain unclear. This study aimed to explore the potential mechanisms of DHZCP in treating thrombosis with a focus on bioinformatics and miRNAs. METHODS: We used network pharmacology to explore the targets of thrombosis treated with DHZCP and performed microarray analysis to acquire miRNA profiles and predict the target genes in thrombin-stimulated MEG-01 cells treated with DHZCP...
March 19, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38531053/predictive-parameters-for-spontaneous-joint-bleeding-during-emicizumab-prophylaxis
#8
JOURNAL ARTICLE
Sara Arcudi, Roberta Gualtierotti, Erica Scalambrino, Marigrazia Clerici, Shermarke Hassan, Valentina Begnozzi, Elena Anna Boccalandro, Cristina Novembrino, Carla Valsecchi, Roberta Palla, Flora Peyvandi
Emicizumab is approved for prophylaxis of patients with hemophilia A (HA). Despite its efficacy in reducing bleeding, a few patients on emicizumab still experience hemarthrosis, but no tool is yet available to identify those at higher risk of spontaneous joint bleeding. To evaluate whether laboratory measurements (global coagulation assays and emicizumab concentration) and/or arthropathy scores can distinguish patients at higher risk of spontaneous joint bleeding while on emicizumab prophylaxis. Thrombin generation assay (TGA) was assessed upon the addition of tissue factor and synthetic phospholipids...
March 26, 2024: Blood Advances
https://read.qxmd.com/read/38529627/effect-of-reduced-inr-in-early-pregnancy-on-the-occurrence-of-preeclampsia-a-retrospective-cohort-study
#9
JOURNAL ARTICLE
Pei-Pei Jin, Ning Ding, Jing Dai, Xiao-Yan Liu, Pei-Min Mao
To investigate the effect of reduced early-pregnancy activated partial thrombin time (APTT), prothrombin time (PT), and international standardized ratio (INR) on the risk of preeclampsia. A total of 8549 pregnant women with singleton births were included. Early pregnancy APTT, PT, and INR levels, with age, birth, prepregnancy body mass index, fibrinogen (FBG), thrombin time (TT), D-dimer (DD2), antithrombin III (ATIII), fibrin degradation products (FDP) as confounders, generalized linear model of APTT, the relative risk of PT and INR when INR reduction...
2024: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/38527572/polyamine-release-and-vesicular-polyamine-transporter-expression-in-megakaryoblastic-cells-and-platelets
#10
JOURNAL ARTICLE
Mizuki Uehara, Ayaka Fukumoto, Hiroshi Omote, Miki Hiasa
Polyamines not only play essential roles in cell growth and function of living organisms but are also released into the extracellular space and function as regulators of chemical transduction, although the cells from which they are released and their mode of release are not well understood. The vesicular polyamine transporter (VPAT), encoded by the SLC18B1 is responsible for the vesicular storage of spermine and spermidine, followed by their vesicular release from secretory cells. Focusing on VPAT will help identify polyamine-secreting cells and new polyamine functions...
March 23, 2024: Biochimica et Biophysica Acta. General Subjects
https://read.qxmd.com/read/38525959/the-effect-of-abcb1-and-ces1-polymorphisms-on-plasma-levels-of-dabigatran-and-risk-of-hemorrhagic-complications-in-ischemic-stroke-patients
#11
JOURNAL ARTICLE
Olšerová Anna, Janský Petr, Magerová Hana, Šrámková Tereza, Kešnerová Petra, Kmetonyová Silvia, Šulc Vlastimil, Halmová Hana, Šrámek Martin, Šarbochová Ivana, Paulasová-Schwabová Jaroslava, Benešová Kateřina, Macek Jan, Maťoška Václav, Tomek Aleš
BACKGROUND: Dabigatran directly inhibits thrombin and is used in primary and secondary stroke prevention in individuals with nonvalvular atrial fibrillation. The prodrug dabigatran etexilate is absorbed by enteral P-glycoprotein (ABCB1) and then activated by hepatic and intestinal carboxylesterases (CES1) to produce active metabolites. Variations in dabigatran metabolism because of genetics may affect concentration levels and clinical outcomes. STUDY QUESTION: We conducted a study to assess how polymorphisms in the CES1 (rs2244613) and ABCB1 (rs4148738) genes affect the through plasma level (cmin) of dabigatran and its correlation to clinical outcomes...
March 20, 2024: American Journal of Therapeutics
https://read.qxmd.com/read/38524596/a-sodium-alginate-silk-fibroin-biosponge-loaded-with-thrombin-effective-hemostasis-and-wound-healing
#12
JOURNAL ARTICLE
Yansen Li, Ming Li, Chang Li, Jing Chang, Yuwen Hui, Chuanlin Wang, Wei Guo, Zhulin Li
In trauma first aid, rapid hemostasis is a priority, extricating patients from hemorrhagic shock and infection risks. This paper explores novel hemostatic materials, using ion-crosslinking and freeze-drying techniques. Iterative experiments determined optimal conditions for the temperature-variable mixing-freeze-drying chemical reaction of sodium alginate (SA)/silk fibroin (SF). We used SA, SA/SF, SA/SF-TB and commercial hemostatic sponge control samples to perform hemostasis experiments on rat liver injury and femoral artery injury models, and to perform wound healing experiments on rat back full-layer skin...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524497/detection-of-%C3%AE-thrombin-with-platelet-glycoprotein-ib%C3%AE-gp1b%C3%AE-for-the-development-of-a-coagulation-marker
#13
JOURNAL ARTICLE
Doogie Oh, Yun Jin Chae, Jie Ying Teoh, Bora Yim, Dongwon Yoo, Yongdoo Park, Jongseong Kim
The detection of prothrombotic markers is crucial for understanding thromboembolism and assessing the effectiveness of anticoagulant drugs. α-Thrombin is a marker that plays a critical role in the coagulation cascade process. However, the detection of this enzymatic molecule was hindered by the absence of an efficient modality in the clinical environment. Previously, we reported that one α-thrombin interacts with two α-chains of glycoprotein Ib (GPIbα), i.e., multivalent protein binding (MPB), using bioresponsive hydrogel nanoparticles (nanogels) and optical microscopy...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38523614/the-effect-of-argatroban-on-early-neurological-deterioration-and-outcomes-in-minor-ischemic-stroke-preliminary-findings
#14
JOURNAL ARTICLE
Xuehong Jin, Xia Li, Hong Zhang, Xiaohan Yao, Yongquan Gu, Shaofang Pei, Lan Hu
BACKGROUND: Minor ischemic stroke (MIS) is associated with early neurological deterioration (END) and poor prognosis. Here, we investigated whether argatroban administration can mitigate MIS-associated END and improve functional outcomes by monitoring activated partial thrombin time (APTT). METHODS: Data were collected for patients with MIS admitted to our hospital from January 2019 to December 2022. Patients were divided into a dual antiplatelet therapy (DAPT) group (aspirin + clopidogrel) and an argatroban group (aspirin + argatroban)...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38523253/the-effects-of-emicizumab-on-in-vitro-coagulation-and-fibrinolysis-parameters-in-patients-with-disseminated-intravascular-coagulation-with-and-without-addition-of-anti-fviii-antibody
#15
JOURNAL ARTICLE
Tomoko Onishi, Hanako Shimo, Suguru Harada, Keiji Nogami
BACKGROUND: Emicizumab (Emi) is used as haemostatic prophylaxis for patients with haemophilia A (PwHA). Disseminated intravascular coagulation (DIC) is a condition characterized by persistent systemic activation of coagulation, but there is yet no information on coagulation and fibrinolysis potentials in Emi-treated PwHA with DIC. AIM: To examine the effect of Emi on coagulation and fibrinolysis potentials in HA-model DIC plasmas. METHODS: Plasma from a patient with sepsis-DIC (seven patients) was treated with anti-factor (F)VIII monoclonal antibody (HA-model DIC plasma) and incubated with Emi (50 µg/mL)...
March 24, 2024: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://read.qxmd.com/read/38523002/low-level-ambient-ozone-exposure-associated-with-neutrophil-extracellular-traps-and-pro-atherothrombotic-biomarkers-in-healthy-adults
#16
JOURNAL ARTICLE
Hongbing Xu, Xinghou He, Bin Zhang, Mengyao Li, Yutong Zhu, Tong Wang, Shengcong Liu, Mushui Shu, Ding Ding, Yu Wang, Qian Zhao, Jianping Li, Xiaoming Song, Wei Huang
BACKGROUND AND AIMS: Uncertainty of the causality determinations for ambient ozone (O3 ) on cardiovascular events is heightened by the limited understanding of the mechanisms involved in humans. We aimed to examine the pro-atherothrombotic impacts of O3 exposure and to explore the potential mediating roles of dysfunctional neutrophils, focusing on neutrophil extracellular traps (NETs). METHODS: A longitudinal panel study of 152 healthy adults was conducted in the cool to cold months with relatively low levels of O3 between September 2019 and January 2020 in Beijing, China...
March 7, 2024: Atherosclerosis
https://read.qxmd.com/read/38521329/a-common-protein-c-inhibitor-exosite-partially-controls-the-heparin-induced-activation-and-inhibition-of-serine-proteases
#17
JOURNAL ARTICLE
Urfi Siddiqui, Abdul Burhan Khan, Tahif Ahmad, Ahmed Abdur Rehman, Mohamad Aman Jairajpuri
Protein C inhibitor (PCI) maintains hemostasis by inhibiting both procoagulant and anticoagulant serine proteases, and plays important roles in coagulation, fibrinolysis, reproduction, and anti-angiogenesis. The reactive site loop of PCI traps and irreversibly inhibits the proteases like APC (activating protein C), thrombin (FIIa) and factor Xa (FXa). Previous studies on antithrombin (ATIII) had identified Tyr253 and Glu255 as functional exosites that interact and aid in the inhibition of factor IXa and FXa...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521192/mathematical-models-of-coagulation-are-we-there-yet
#18
JOURNAL ARTICLE
Matt J Owen, Joy R Wright, Edward G D Tuddenham, John R King, Alison H Goodall, Joanne L Dunster
BACKGROUND: Mathematical models of coagulation have been developed to mirror thrombin generation in plasma, with the aim of investigating how variation in coagulation factor levels regulate haemostasis. However, current models vary in the reactions they capture, in reaction rates used, and their validation is restricted by a lack of large coherent datasets, resulting in questioning of their utility. OBJECTIVES AND METHODS: To address this debate, we systematically assessed current models against a large dataset, using plasma coagulation factor levels from 348 individuals with normal haemostasis as inputs, and compared model predictions with measured thrombin generation...
March 21, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38521157/neuropathic-corneal-pain-tear-proteomic-and-neuromediator-profiles-imaging-features-and-clinical-manifestations
#19
JOURNAL ARTICLE
Chang Liu, Molly Tzu-Yu Lin, Isabelle Xin Yu Lee, Jipson Hon Fai Wong, Daqian Lu, Thomas Chuen Lam, Lei Zhou, Jodhbir S Mehta, Hon Shing Ong, Marcus Ang, Louis Tong, Yu-Chi Liu
PURPOSE: To investigate the tear proteomic and neuromediator profiles, in vivo confocal microscopy (IVCM) imaging features, and clinical manifestations in neuropathic corneal pain (NCP) patients. DESIGN: Cross-sectional study. METHODS: Twenty NCP patients and twenty age-matched controls were recruited. All subjects were evaluated by corneal sensitivity, Schirmer's test, tear break-up time, corneal and ocular surface staining, Ocular Surface Disease Index and Ocular Pain Assessment Survey questionnaires, as well as IVCM examinations for corneal nerves, microneruomas, epithelial and dendritic cells...
March 21, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38521125/thrombin-stories-in-the-gut
#20
REVIEW
Nathalie Vergnolle
Many studies have demonstrated the involvement of proteases in gut physiology and pathophysiology over the recent years. Among them, thrombin has appeared for a long time as an old player only involved in blood clotting upon tissue injury. The fact that thrombin receptors (Protease-Activated Receptors-1 and -4) are expressed and functional in almost all cell types of the gut, contributing to barrier, immune or motility functions, suggested that thrombin could actually be at the crossroad of intestinal physiology...
March 21, 2024: Biochimie
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