José C Dayoub, Francisco Ortiz, Luis C López, Carmen Venegas, Alberto Del Pino-Zumaquero, Olga Roda, Indalecio Sánchez-Montesinos, Darío Acuña-Castroviejo, Germaine Escames
The beneficial effects of atorvastatin are based on both cholesterol-dependent and independent mechanisms. The latter probably include the ability of the estatin to enhance the expression of endothelial nitric oxide synthase (eNOS) and to cause a vasodilatation. In turn, the antioxidant and anti-inflammatory actions of melatonin are related to its vascular protection. In the present study, we investigated the efficacy of the combination of melatonin plus atorvastatin against endothelial cell damage induced by inflammation and oxidative stress injury...
October 2011: Journal of Pineal Research