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Alexander R Goldberg, Athanassios Dovas, Daniela Torres, Sohani Das Sharma, Angeliki Mela, Edward M Merricks, Markel Olabarria, Leila Abrishami Shokooh, Hanzhi T Zhao, Corina Kotidis, Peter Calvaresi, Ashwin Viswanathan, Matei A Banu, Aida Razavilar, Tejaswi D Sudhakar, Ankita Saxena, Cole Chokran, Nelson Humala, Aayushi Mahajan, Weihao Xu, Jordan B Metz, Cady Chen, Eric A Bushong, Daniela Boassa, Mark H Ellisman, Elizabeth M C Hillman, Guy M McKhann, Brian J A Gill, Steven S Rosenfeld, Catherine A Schevon, Jeffrey N Bruce, Peter A Sims, Darcy S Peterka, Peter Canoll
Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor microenvironment, including neurons. Neurons are increasingly appreciated as important reactive components of the glioma microenvironment, due to their role in causing hallmark glioma symptoms, such as cognitive deficits and seizures, as well as their potential ability to drive glioma progression. Separately, mTOR signaling has been shown to have pleiotropic effects in the brain tumor microenvironment, including regulation of neuronal hyperexcitability...
January 21, 2024: bioRxiv
#22
JOURNAL ARTICLE
Georgii Kostiuchik, Lalith Sharan, Benedikt Mayer, Ivo Wolf, Bernhard Preim, Sandy Engelhardt
PURPOSE: Machine learning approaches can only be reliably evaluated if training, validation, and test data splits are representative and not affected by the absence of classes. Surgical workflow and instrument recognition are two tasks that are complicated in this manner, because of heavy data imbalances resulting from different length of phases and their potential erratic occurrences. Furthermore, sub-properties like instrument (co-)occurrence are usually not particularly considered when defining the split...
January 29, 2024: International Journal of Computer Assisted Radiology and Surgery
#23
JOURNAL ARTICLE
Lou Cady, Marie Costes, Emilie Andres, Franck Dillinger, Dominique Somme
The practice of telemedicine in nursing homes is a solution to improve the quality of care for residents. Its application also seems to be beneficial for the professionals involved, but it faces obstacles. The objective of this study is to explore the effects of the implementation of teleconsultations in nursing homes on the professional practices of the stakeholders involved. A qualitative focus group study was conducted with professionals involved in the implementation of teleconsultations. The data was analyzed using an inductive approach similar to grounded theory...
December 1, 2023: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
#24
JOURNAL ARTICLE
Bouchra Darkaoui, Mohamed Aksim, Ayoub Aarab, Ayoub Lafnoune, Soukaina Khourcha, Rachida Cadi, Ouafaa Aniq Filali, Naoual Oukkache
In North Africa, scorpion stings pose an urgent public health problem, particularly for children with high morbidity and mortality rates. The main species implicated are the Androctonus mauretanicus ( Am ), Androctonus australis hector ( Aah ), and Buthus occitanus ( Bo ). Immunotherapy is the specific therapeutic approach aimed at directly neutralizing toxins, despite their severity and rapid diffusion. In the present study, we evaluate, histologically and immunohistologically, the neutralization potency of the selective antivenom produced against, among other species, the Am , Aah , and Bo at the level of the tissue alterations in Swiss mice, as experimental subjects...
December 27, 2023: Toxins
#25
JOURNAL ARTICLE
Sarah J Aziz, Brendan C Dickson, Pencilla Lang, Cady E Zeman
NUT carcinoma is a rare, aggressive malignancy defined as a carcinoma with a chromosomal rearrangement affecting the nuclear protein in testis ( NUTM1 ) gene. This small round blue cell tumor classically exhibits focal abrupt keratinization and immunohistochemical positivity for keratin and squamous markers. However, keratinization is not always present and reports of positivity for other markers that may obscure the diagnosis are increasing. It is also noteworthy that gene fusions involving NUTM1 are not restricted to NUT carcinoma...
January 17, 2024: International Journal of Surgical Pathology
#26
JOURNAL ARTICLE
Romain Lécuyer, Nahéma Issa, Fabrice Camou, Rose-Anne Lavergne, Frederic Gabriel, Florent Morio, Emmanuel Canet, François Raffi, David Boutoille, Anne Cady, Marie Gousseff, Yoann Crabol, Antoine Néel, Benoît Tessoulin, Benjamin Gaborit
BACKGROUND: Pneumocystis jirovecii pneumonia (PcP) remains associated with high rates of mortality and the impact of immunocompromising underlying disease on the clinical presentation, severity and mortality of PcP has not been adequately evaluated. RESEARCH QUESTION: Does the underlying disease and immunosuppression causing Pneumocystis jirovecii pneumonia (PcP) impact the outcome and clinical presentation of the disease? STUDY DESIGN AND METHODS: In this multicentre retrospective observational study, conducted from January 2011 to December 2021, all consecutive patients admitted with a proven or probable diagnosis of PcP according to The European Organization for Research and Treatment of Cancer (EORTC) consensus definitions were included to assess the epidemiology and impact of underlying immunosuppressive diseases on overall and 90-day mortality...
January 10, 2024: Chest
#27
JOURNAL ARTICLE
Marta Szepietowska, Aleksandra A Stefaniak, Piotr K Krajewski, Lukasz Matusiak
Acne is a common skin condition affecting both adolescents and adults, and it can profoundly impact patients' quality of life and mental well-being. This prospective cross-sectional study aims to explore the differences in psychosocial aspects between male and female acne patients in Poland. A total of 104 consecutive acne patients were included in this study. Clinical severity, patients' quality of life, stigmatization levels, and psychiatric disturbances were evaluated using the following instruments: Investigator Global Assessment (IGA), Dermatology Life Quality Index (DLQI), Cardiff Acne Disability Index (CADI), 6-Item Stigmatization Scale (6-ISS), and Hospital Anxiety and Depression Scale (HADS)...
December 19, 2023: Journal of Clinical Medicine
#28
JOURNAL ARTICLE
Binh Duong Giap, Karthik Srinivasan, Ossama Mahmoud, Shahzad I Mian, Bradford L Tannen, Nambi Nallasamy
Cataract surgery remains the only definitive treatment for visually significant cataracts, which are a major cause of preventable blindness worldwide. Successful performance of cataract surgery relies on stable dilation of the pupil. Automated pupil segmentation from surgical videos can assist surgeons in detecting risk factors for pupillary instability prior to the development of surgical complications. However, surgical illumination variations, surgical instrument obstruction, and lens material hydration during cataract surgery can limit pupil segmentation accuracy...
December 21, 2023: IEEE Journal of Biomedical and Health Informatics
#29
JOURNAL ARTICLE
Belinda J Hernandez, Nikolai P Skiba, Karolina Plössl, Madison Strain, Yutao Liu, Daniel Grigsby, Una Kelly, Martha A Cady, Vikram Manocha, Arvydas Maminishkis, TeddiJo Watkins, Sheldon S Miller, Allison Ashley-Koch, W Daniel Stamer, Bernhard H F Weber, Catherine Bowes Rickman, Mikael Klingeborn
The retinal pigmented epithelium (RPE) constitutes the outer blood-retinal barrier, enables photoreceptor function of the eye, and is constantly exposed to oxidative stress. As such, dysfunction of the RPE underlies pathology leading to development of age-related macular degeneration (AMD), the leading cause of vision loss among the elderly in industrialized nations. A major responsibility of the RPE is to process photoreceptor outer segments, which relies on the proper functioning of its endocytic pathways and endosomal trafficking...
October 2023: J Extracell Biol
#30
JOURNAL ARTICLE
Maysen E Calzon, Bilal Koussayer, Joseph Sujka
The purpose of this paper is to describe a robotic surgical technique for converting a slipped Nissen fundoplication to a Toupet fundoplication. Our technique utilizes four 8 mm robotic ports placed in a horizontal pattern above the umbilicus. The robotic tools we used are a vessel sealer, bipolar forceps, and Cadière forceps. In addition, an esophagogastroduodenoscopy (EGD) is placed through the esophagus into the stomach to be used as a bougie. If a hernia is present, we dissect it from the mediastinum until the posterior confluence is identified...
December 9, 2023: Updates in Surgery
#31
JOURNAL ARTICLE
A S M Morshed, Towhida Noor, Md Ashraf Uddin Ahmed, Fahmida Sultana Mili, Shuma Ikram, Mashiqur Rahman, Shamim Ahmed, Mohammad Borhan Uddin
Acne vulgaris (AV) is a psychosomatic disorder and can negatively affect individuals, especially in terms of psychological well-being, self-esteem, and quality of life (QoL). The current study aimed to investigate the association between AV and psychological health, as well as the influence of acne and psychological distress in predicting patients' self-esteem and QoL. This cross-sectional study included 150 patients clinically diagnosed with AV. The severity of acne was measured using GAGS, and following that, patients were instructed to complete the following forms: DASS-21, RSES, CADI, DLQI, and WHOQoL...
November 30, 2023: Scientific Reports
#32
JOURNAL ARTICLE
Phil Cady, Cheryl Heykoop
The field of health leadership is shifting rapidly, and there is an opportunity to learn with health leaders about what is needed to support health leadership education, research, and practice. In 2022, to augment student feedback and faculty praxis, Royal Roads University (RRU) conducted 12 virtual interviews with senior health system leaders across various settings to learn how health leaders can better respond to emerging and future leadership needs and priorities facing health systems. Findings from this study informed the development of a health-specific elective for the MAL-H program entitled Considerations for Health Systems Renewal...
November 17, 2023: Healthcare Management Forum
#33
JOURNAL ARTICLE
Michael A Gargano, Nicolas Matentzoglu, Ben Coleman, Eunice B Addo-Lartey, Anna V Anagnostopoulos, Joel Anderton, Paul Avillach, Anita M Bagley, Eduard Bakštein, James P Balhoff, Gareth Baynam, Susan M Bello, Michael Berk, Holli Bertram, Somer Bishop, Hannah Blau, David F Bodenstein, Pablo Botas, Kaan Boztug, Jolana Čady, Tiffany J Callahan, Rhiannon Cameron, Seth J Carbon, Francisco Castellanos, J Harry Caufield, Lauren E Chan, Christopher G Chute, Jaime Cruz-Rojo, Noémi Dahan-Oliel, Jon R Davids, Maud de Dieuleveult, Vinicius de Souza, Bert B A de Vries, Esther de Vries, J Raymond DePaulo, Beata Derfalvi, Ferdinand Dhombres, Claudia Diaz-Byrd, Alexander J M Dingemans, Bruno Donadille, Michael Duyzend, Reem Elfeky, Shahim Essaid, Carolina Fabrizzi, Giovanna Fico, Helen V Firth, Yun Freudenberg-Hua, Janice M Fullerton, Davera L Gabriel, Kimberly Gilmour, Jessica Giordano, Fernando S Goes, Rachel Gore Moses, Ian Green, Matthias Griese, Tudor Groza, Weihong Gu, Julia Guthrie, Benjamin Gyori, Ada Hamosh, Marc Hanauer, Kateřina Hanušová, Yongqun Oliver He, Harshad Hegde, Ingo Helbig, Kateřina Holasová, Charles Tapley Hoyt, Shangzhi Huang, Eric Hurwitz, Julius O B Jacobsen, Xiaofeng Jiang, Lisa Joseph, Kamyar Keramatian, Bryan King, Katrin Knoflach, David A Koolen, Megan L Kraus, Carlo Kroll, Maaike Kusters, Markus S Ladewig, David Lagorce, Meng-Chuan Lai, Pablo Lapunzina, Bryan Laraway, David Lewis-Smith, Xiarong Li, Caterina Lucano, Marzieh Majd, Mary L Marazita, Victor Martinez-Glez, Toby H McHenry, Melvin G McInnis, Julie A McMurry, Michaela Mihulová, Caitlin E Millett, Philip B Mitchell, Veronika Moslerová, Kenji Narutomi, Shahrzad Nematollahi, Julian Nevado, Andrew A Nierenberg, Nikola Novák Čajbiková, John I Nurnberger, Soichi Ogishima, Daniel Olson, Abigail Ortiz, Harry Pachajoa, Guiomar Perez de Nanclares, Amy Peters, Tim Putman, Christina K Rapp, Ana Rath, Justin Reese, Lauren Rekerle, Angharad M Roberts, Suzy Roy, Stephan J Sanders, Catharina Schuetz, Eva C Schulte, Thomas G Schulze, Martin Schwarz, Katie Scott, Dominik Seelow, Berthold Seitz, Yiping Shen, Morgan N Similuk, Eric S Simon, Balwinder Singh, Damian Smedley, Cynthia L Smith, Jake T Smolinsky, Sarah Sperry, Elizabeth Stafford, Ray Stefancsik, Robin Steinhaus, Rebecca Strawbridge, Jagadish Chandrabose Sundaramurthi, Polina Talapova, Jair A Tenorio Castano, Pavel Tesner, Rhys H Thomas, Audrey Thurm, Marek Turnovec, Marielle E van Gijn, Nicole A Vasilevsky, Markéta Vlčková, Anita Walden, Kai Wang, Ron Wapner, James S Ware, Addo A Wiafe, Samuel A Wiafe, Lisa D Wiggins, Andrew E Williams, Chen Wu, Margot J Wyrwoll, Hui Xiong, Nefize Yalin, Yasunori Yamamoto, Lakshmi N Yatham, Anastasia K Yocum, Allan H Young, Zafer Yüksel, Peter P Zandi, Andreas Zankl, Ignacio Zarante, Miroslav Zvolský, Sabrina Toro, Leigh C Carmody, Nomi L Harris, Monica C Munoz-Torres, Daniel Danis, Christopher J Mungall, Sebastian Köhler, Melissa A Haendel, Peter N Robinson
The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English...
January 5, 2024: Nucleic Acids Research
#34
JOURNAL ARTICLE
Phil Cady
The organic systems framework is a conceptual social sciences theoretical framework developed by renowned author Barry Oshry. Oshry outlines how we are often blind to the context we are in and our reactions to those conditions, which leads to certain experiences. This article emanates from the author's reflections on bringing organic systems insights to groups and organizations worldwide and how such strategies in relational systems may apply to patients and care providers working together in partnership. As patients and care providers engage in such partnerships, they enter distinctly different contexts, each with unique challenges and opportunities...
November 10, 2023: Healthcare Management Forum
#35
JOURNAL ARTICLE
Nicolas Massart, Emma Plainfosse, Yanis Benameur, Clarisse Dupin, Florence Legall, Anne Cady, Frederic Gourmelin, François Legay, Nicolas Barbarot, Eric Magalhaes, Pierre Fillatre, Aurélien Frerou, Florian Reizine
BACKGROUND: Predictors of ICU-acquired pulmonary aspergillosis (IPA) are not well-established in critically ill patients with ventilator-associated pneumonia (VAP), making IPA commonly misdiagnosed and anti-fungal therapy delayed. We aimed to develop a clinical score for prediction of IPA among patients with VAP. METHODS: Mechanically ventilated patients who developed VAP in 4 ICUs in Bretagne, Western France, were included. The score was constructed in a learning cohort, based on predictors of IPA in logistic regression model, and validated in a validation cohort...
November 7, 2023: Annals of Intensive Care
#36
JOURNAL ARTICLE
Fernando Pesantez Torres, Natalya Tokranova, Eleanor Amodeo, Taylor Bertucci, Thomas R Kiehl, Yubing Xie, Nathaniel C Cady, Susan T Sharfstein
The biocompatibility of materials used in electronic devices is critical for the development of implantable devices like pacemakers and neuroprosthetics, as well as in future biomanufacturing. Biocompatibility refers to the ability of these materials to interact with living cells and tissues without causing an adverse response. Therefore, it is essential to evaluate the biocompatibility of metals and semiconductor materials used in electronic devices to ensure their safe use in medical applications. Here, we evaluated the biocompatibility of a collection of diced silicon chips coated with a variety of metal thin films, interfacing them with different cell types, including murine mastocytoma cells in suspension culture, adherent NIH 3T3 fibroblasts, and human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs)...
October 13, 2023: Biosensors & Bioelectronics
#37
JOURNAL ARTICLE
Jemmie Hoang, Stephanie Gilbertson-White, Nicole Cady, Meeta Yadav, Shailesh Shahi, Leeann Aguilar, Ashutosh K Mangalam, Catherine Cherwin
BACKGROUND: Alterations in the naturally occurring bacteria of the gut, known as the gastrointestinal (GI) microbiome, may influence GI symptoms in women with breast cancer. OBJECTIVE: This work aims to describe GI symptom occurrence, duration, severity, and distress and measures of the GI microbiome among women with breast cancer receiving chemotherapy compared to age- and sex-matched healthy controls. INTERVENTIONS/METHODS: 22 women with breast cancer receiving chemotherapy and 17 healthy control women provided stool specimens and GI symptom data using the modified Memorial Symptom Assessment Scale (MSAS)...
October 13, 2023: Biological Research for Nursing
#38
JOURNAL ARTICLE
Yao Abusa, Philip Yox, Sarah D Cady, Gayatri Viswanathan, Jemima Opare-Addo, Emily A Smith, Yaroslav Mudryk, Oleg I Lebedev, Frédéric A Perras, Kirill Kovnir
The inertness of elemental selenium is a significant obstacle in the synthesis of selenium-containing materials at low reaction temperatures. Over the years, several recipes have been developed to overcome this hurdle; however, most of the methods are associated with the use of highly toxic, expensive, and environmentally harmful reagents. As such, there is an increasing demand for the design of cheap, stable, and nontoxic reactive selenium precursors usable in the low-temperature synthesis of transition metal selenides with vast applications in nanotechnology, thermoelectrics, and superconductors...
October 9, 2023: Journal of the American Chemical Society
#39
JOURNAL ARTICLE
Manolya Gul Balbay, Maximillian D Shlafstein, Charles Cockell, Sherry L Cady, Rebecca D Prescott, Darlene S S Lim, Patrick S G Chain, Stuart P Donachie, Alan W Decho, Jimmy H Saw
Members of the archaeal order Caldarchaeales (previously the phylum Aigarchaeota) are poorly sampled and are represented in public databases by relatively few genomes. Additional representative genomes will help resolve their placement among all known members of Archaea and provide insights into their roles in the environment. In this study, we analyzed 16S rRNA gene amplicons belonging to the Caldarchaeales that are available in public databases, which demonstrated that archaea of the order Caldarchaeales are diverse, widespread, and most abundant in geothermal habitats...
2023: Frontiers in Microbiology
#40
JOURNAL ARTICLE
Mikala M Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E Mead, Zachary A Kipp, Evelyn A Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R Shelman, Harrison A Clarke, Tara R Hawkinson, Terrymar Medina, Ramon C Sun, Todd A Lydic, Terry D Hinds, J Mark Brown, Samir Softic, Gregory A Graf, Robert N Helsley
BACKGROUND AND AIMS: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic lipid metabolism. APPROACH AND RESULTS: Male and female liver-specific knockout (LKO) and littermate controls were placed on a low-fat or high-fat diet (60% kcal fat) for 15 weeks. Mice were necropsied after a 16 hour fast, and tissues were collected for lipidomics, matrix-assisted laser desorption ionization mass spectrometry imaging, kinome analysis, RNA-sequencing, and protein expression by immunoblotting...
October 3, 2023: Molecular Metabolism
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