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https://www.readbyqxmd.com/read/27885250/cxc-chemokine-receptor-4-cxcr4-antagonist-a-novel-pathway-to-prevent-chronic-allograft-nephropathy
#1
Yue Xu, Qiang Zhang, Wenrui Xue, Song Zeng, Zijian Zhang, Xiaodong Zhang, Xiaopeng Hu
BACKGROUND Chronic allograft nephropathy (CAN) remains a major problem for long-term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4) is significantly upregulated following renal injury and fibrotic response. We investigated the effect of AMD3100, a CXCR4 antagonist, on the development of CAN in rat models. MATERIAL AND METHODS CAN rat models (n=20) were established using male Fisher 344 to Lewis rats. Rats in the experimental group (n=10) were treated with AMD3100 (1 mg/kg/day subcutaneously, 0-12 weeks), rats in the control group (n=10) were treated with saline...
November 25, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27831503/a-randomized-trial-of-tlr-2-agonist-cadi-05-targeting-desmocollin-3-for-advanced-non-small-cell-lung-cancer
#2
C P Belani, B Chakraborty, R Modi, B Khamar
BACKGROUND: Randomised controlled trial to evaluate synergy between taxane plus platinum chemotherapy and CADI-05, a TLR-2 agonist targeting desmocollin-3 as a first line therapy in advanced Non Small cell lung cancer (NSCLC). PATIENTS AND METHODS: Patients with advanced NSCLC (stage IIIB or IV) were randomized to Cisplatin-Paclitaxel (Chemotherapy group, N=112) or Cisplatin-Paclitaxel plus CADI-05 (Chemoimmunotherapy group, N=109). CADI-05 was administered a week prior to chemotherapy and on day 8 and 15 of each cycle and every month subsequently for 12 months or disease progression...
November 9, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27776675/structure-of-problem-recognition-questionnaire-with-hispanic-latino-adolescents
#3
Evan T Stanforth, Brian E McCabe, Maite P Mena, Daniel A Santisteban
Motivation is a prominent target for substance use interventions because it is theorized to increase engagement in therapy and predict treatment outcomes. Establishing the validity of measures relevant to motivation among Hispanic/Latino adolescents will improve the resources available for screening and measuring change processes in a multicultural population. We examined the structure of the Problem Recognition Questionnaire (PRQ; Cady, Winters, Jordan, Solberg, & Stinchfield, 1996) with Hispanic/Latino adolescents...
December 2016: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/27719633/the-efficiency-of-tat-cell-penetrating-peptide-for-intracellular-uptake-of-hiv-1-nef-expressed-in-e-coli-and-mammalian-cell
#4
Somayeh Kadkhodayan, Azam Bolhassani, Seyed Mehdi Sadat, Shiva Irani, Fatemeh Fotouhi
Cell penetrating peptides (CPPs) or protein transduction domains (PTDs) have been known as a new field in cargo delivery. These peptides such as Tat, Pep-1 and Cady-2 are able to deliver genes and biologically active proteins to cytoplasmic compartments via the plasma membrane. In current study, the efficiency of pEGFP-N1 eukaryotic vector for expression of HIV-1 Tat-Nef fusion was evaluated in HEK-293T cells using TurboFect transfection reagent. In addition, the recombinant GST-Tat-Nef protein was generated in E...
October 6, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27637093/detoxification-of-polycyclic-aromatic-hydrocarbons-pahs-in-arabidopsis-thaliana-involves-a-putative-flavonol-synthase
#5
Juan C Hernández-Vega, Brian Cady, Gilbert Kayanja, Anthony Mauriello, Natalie Cervantes, Andrea Gillespie, Lisa Lavia, Joshua Trujillo, Merianne Alkio, Adán Colón-Carmona
Polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants with cytotoxic, teratogenic and carcinogenic properties. Bioremediation studies with bacteria have led to the identification of dioxygenases (DOXs) in the first step to degrade these recalcitrant compounds. In this study, we characterized the role of the Arabidopsis thaliana AT5G05600, a putative DOX of the flavonol synthase family, in the transformation of PAHs. Phenotypic analysis of loss-of-function mutant lines showed that these plant lines were less sensitive to the toxic effects of phenanthrene, suggesting possible roles of this gene in PAH degradation in vivo...
August 24, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27610955/significant-reduction-of-inflammation-and-sebaceous-glands-size-in-acne-vulgaris-lesions-after-intense-pulsed-light-treatment
#6
Manal T Barakat, Noha H Moftah, Mohammad A M El Khayyat, Zainab A Abdelhakim
Intense pulsed light (IPL) has been used for years in treatment of acne vulgaris. However, quantitative evaluation of histopathological changes after its use as a sole therapy was poorly investigated. Accordingly, this study aims to objectively evaluate inflammatory infiltrate and sebaceous glands in acne vulgaris after IPL. Twenty-four patients of acne were treated with six IPL sessions. Clinical evaluation was done at 2 weeks after last session by counting acne lesions. Patient satisfaction using Cardiff Acne Disability Index (CADI) was recorded at baseline, 2 weeks and 3 months after IPL...
September 9, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27595774/effect-of-semen-preparation-technique-and-its-incubation-on-sperm-quality-in-the-moroccan-population
#7
S Aboulmaouahib, A Madkour, I Kaarouch, B Saadani, O Sefrioui, N Louanjli, H Copin, R Cadi, M Benkhalifa
In in vitro fertilisation (IVF), sperm preparation as critical part and influencing the sperm quality is especially dependent on the chosen technique itself and incubation parameters including temperature and CO2. In this study, we compared firstly density-gradient centrifugation technique (DGC) to the adapted DGC using the sperm pellet of 80% fraction (DGC/80P) in order to improve the sperm yield. Secondly, this study led to evaluate different sperm incubation conditions based on temperature effect (room temperature (RT = 23°C) versus 35°C) and in the other hand, with or without 5% CO2 during 24 hrs...
September 5, 2016: Andrologia
https://www.readbyqxmd.com/read/27591993/directions-for-the-advancement-of-culturally-adapted-preventive-interventions-local-adaptations-engagement-and-sustainability
#8
Manuel Barrera, Cady Berkel, Felipe González Castro
To advance the implementation and dissemination of culturally adapted interventions to diverse populations, greater attention should be devoted to three underdeveloped topics: (a) local adaptations of interventions when they are implemented in community settings, (b) participant engagement, and (c) the sustainability of adapted interventions. Several typologies have been developed for studying local adaptations, and some research indicates that such adaptations might add to intervention effectiveness. There is suggestive evidence of ethnocultural group disparities in intervention engagement and in the success of efforts to boost engagement...
September 3, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27568919/the-development-and-validation-of-an-acne-self-regulation-inventory
#9
Yi-Shan Liu, Cheuk-Kwan Sun, Tzong-Shiun Li, Chia-Ju Liu
BACKGROUND: Acne, an inflammatory disease of the pilosebaceous unit, is now recognized and investigated as a chronic disease. Since the physiological and psychosocial impact of acne may be long-lasting, the treatment of acne vulgaris poses a formidable challenge for dermatologists. OBJECTIVE: The present study aims at investigating the validity and reliability of a self-developed instrument "acne self-regulation inventory" (ASRI) based on self-regulation theory in assessing the selfregulation ability of acne patients as part of the therapeutic strategy...
August 18, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27555927/crystallographic-and-spectroscopic-characterization-of-r-o-acetyl-mandelic-acid
#10
Cady Cirbes, Joseph M Tanski
The title compound [systematic name: (R)-(-)-2-acet-oxy-2-phenyl-acetic acid], C10H10O4, is a resolved chiral ester derivative of mandelic acid. The compound contains an acetate group and a carb-oxy-lic acid group, which engage in inter-molecular hydrogen bonding, forming chains extending parallel to [001] with a short donor-acceptor hydrogen-bonding distance of 2.676 (2) Å.
July 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27543747/measurement-properties-of-quality-of-life-measurement-instruments-for-infants-children-and-adolescents-with-eczema-a-systematic-review
#11
D Heinl, C A C Prinsen, T Sach, A M Drucker, R Ofenloch, C Flohr, C Apfelbacher
BACKGROUND: Quality of life (QoL) is one of the core outcome domains identified by the Harmonising Outcome Measures for Eczema (HOME) initiative to be assessed in every eczema trial. There is uncertainty about the most appropriate QoL instrument to measure this domain in infants, children and adolescents. OBJECTIVES: To systematically evaluate the measurement properties of existing measurement instruments developed and/or validated for the measurement of QoL in infants, children and adolescents with eczema...
August 20, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27532779/interview-with-penelope-boston-director-of-the-nasa-astrobiology-institute
#12
Sherry L Cady, Penelope Boston
No abstract text is available yet for this article.
August 2016: Astrobiology
https://www.readbyqxmd.com/read/27516189/generation-of-gfp-native-protein-for-detection-of-its-intracellular-uptake-by-cell-penetrating-peptides
#13
S Kadkhodayan, S M Sadat, S Irani, F Fotouhi, A Bolhassani
Different types of lipid- and polymer-based vectors have been developed to deliver proteins into cells, but these methods showed relatively poor efficiency. Recently, a group of short, highly basic peptides known as cell-penetrating peptides (CPPs) were used to carry polypeptides and proteins into cells. In this study, expression and purification of GFP protein was performed using the prokaryotic pET expression system. We used two amphipathic CPPs (Pep-1 and CADY-2) as a novel delivery system to transfer the GFP protein into cells...
2016: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/27498285/-acne-in-cameroon-quality-of-life-and-psychiatric-comorbidities
#14
E A Kouotou, H Adegbidi, R Bene Belembe, I Sieleunou, J R Nansseu, J-P Kamga, E C Ndjitoyap Ndam
BACKGROUND AND AIMS: The impact of acne upon quality of life (QOL) among affected patients had not previously been investigated in Cameroon. The present study therefore sought to assess the QOL of patients with acne and related psychiatric comorbidities in this country. PATIENTS AND METHODS: This was a cross-sectional study conducted in three hospitals in Yaoundé, Cameroon. We included patients diagnosed with acne after a consultation with a dermatologist, and who consented to participate in the study...
October 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27494307/psychotherapy-for-families-after-brain-injury
#15
Cady K Block, Doug Johnson-Greene
No abstract text is available yet for this article.
August 5, 2016: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/27452608/biopsy-transcriptome-expression-profiling-to-identify-kidney-transplants-at-risk-of-chronic-injury-a-multicentre-prospective-study
#16
MULTICENTER STUDY
Philip J O'Connell, Weijia Zhang, Madhav C Menon, Zhengzi Yi, Bernd Schröppel, Lorenzo Gallon, Yi Luan, Ivy A Rosales, Yongchao Ge, Bojan Losic, Caixia Xi, Christopher Woytovich, Karen L Keung, Chengguo Wei, Ilana Greene, Jessica Overbey, Emilia Bagiella, Nader Najafian, Milagros Samaniego, Arjang Djamali, Stephen I Alexander, Brian J Nankivell, Jeremy R Chapman, Rex Neal Smith, Robert Colvin, Barbara Murphy
BACKGROUND: Chronic injury in kidney transplants remains a major cause of allograft loss. The aim of this study was to identify a gene set capable of predicting renal allografts at risk of progressive injury due to fibrosis. METHODS: This Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multicentre study. We prospectively collected biopsies from renal allograft recipients (n=204) with stable renal function 3 months after transplantation. We used microarray analysis to investigate gene expression in 159 of these tissue samples...
September 3, 2016: Lancet
https://www.readbyqxmd.com/read/27436143/effect-of-angiofibromas-on-quality-of-life-and-access-to-care-in-tuberous-sclerosis-patients-and-their-caregivers
#17
Cary Crall, Molly Valle, Kush Kapur, Kira A Dies, Marilyn G Liang, Mustafa Sahin, Jennifer T Huang
BACKGROUND/OBJECTIVES: Facial angiofibromas (AF) have the potential to cause disfigurement in children with tuberous sclerosis complex (TSC). Facial disfigurement can impact the quality of life (QoL) of individuals and their families, leading to negative psychosocial outcomes. QoL has not been studied in TSC patients with AF. METHODS: We conducted a cross-sectional survey study to investigate QoL of TSC patients with AF and their caregivers and to explore the current state of access to treatment for AF...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27412146/chronic-migraine-headache-prevention-with-noninvasive-vagus-nerve-stimulation-the-event-study
#18
Stephen D Silberstein, Anne H Calhoun, Richard B Lipton, Brian M Grosberg, Roger K Cady, Stefanie Dorlas, Kristy A Simmons, Chris Mullin, Eric J Liebler, Peter J Goadsby, Joel R Saper
OBJECTIVE: To evaluate the feasibility, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS) for the prevention of chronic migraine (CM) attacks. METHODS: In this first prospective, multicenter, double-blind, sham-controlled pilot study of nVNS in CM prophylaxis, adults with CM (≥15 headache d/mo) entered the baseline phase (1 month) and were subsequently randomized to nVNS or sham treatment (2 months) before receiving open-label nVNS treatment (6 months)...
August 2, 2016: Neurology
https://www.readbyqxmd.com/read/27405512/predictors-of-participation-in-the-family-check-up-program-a-randomized-trial-of-yearly-services-from-age-2-to-10-years
#19
Justin D Smith, Cady Berkel, Katherine A Hails, Thomas J Dishion, Daniel S Shaw, Melvin N Wilson
A key challenge of community-based prevention programs is engaging families in the context of services settings involving children and families. The Family Check-Up (FCU) program is designed to engage families in parenting support appropriate to their level of need by use of assessment-enhanced motivational interviewing. This study involved families screened for risk who were seeking services at women, infant, and children's offices in three geographical regions (N = 731). Families in the randomized intervention group (N = 367) were offered the FCU yearly, from age 2 through 10...
July 13, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27390387/protocol-for-a-retrospective-controlled-cohort-study-of-the-impact-of-a-change-in-nature-journals-editorial-policy-for-life-sciences-research-on-the-completeness-of-reporting-study-design-and-execution
#20
Fala Cramond, Cadi Irvine, Jing Liao, David Howells, Emily Sena, Gillian Currie, Malcolm Macleod
In recent years there has been increasing concern about the rigor of laboratory research. Here we present the protocol for a study comparing the completeness of reporting of in vivo and in vitro research carried in Nature Publication Group journals before and after the introduction of a change in editorial policy (the introduction of a set of guidelines for reporting); and in similar research published in other journals in the same periods.
2016: Scientometrics
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