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https://www.readbyqxmd.com/read/28196423/fecal-microbiota-transplantation-is-there-a-role-in-the-eradication-of-carbapenem-resistant-klebsiella-pneumoniae-intestinal-carriage
#1
Ana Ponte, Rolando Pinho, Margarida Mota
The authors present the case of a 66-year-old woman with four hospitalizations due to recurrent Clostridium difficile infection (CDI) non responsive to vancomycin and fidaxomicin. Furthermore, intestinal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKP) was identified after a positive stool culture in a screening routinely performed in our center in patients recently hospitalized.
February 15, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28013258/epidemiology-of-carbapenem-resistant-klebsiella-pneumoniae-in-a-network-of-long-term-acute-care-hospitals
#2
Jennifer H Han, Ellie J C Goldstein, Jacqueleen Wise, Warren B Bilker, Pam Tolomeo, Ebbing Lautenbach
BACKGROUND: The rapid emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major public health threat, including in the long-term acute care hospital (LTACH) setting. The objective of this study was to describe the epidemiologic characteristics of CRKP in a network of United States LTACHs. METHODS: An observational study was performed among 64 LTACHs from January 2014 to March 2015. Clinical cultures were included, with the first CRKP isolate recovered from each patient per study quarter evaluated...
December 24, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27980379/epidemiology-and-biomolecular-characterization-of-carbapenem-resistant-klebsiella-pneumoniae-in-an-italian-hospital
#3
REVIEW
M L Cristina, M Sartini, G Ottria, E Schinca, N Cenderello, M P Crisalli, P Fabbri, G Lo Pinto, D Usiglio, A M Spagnolo
OBJECTIVE: To describe the occurrence of CRKP infections in a tertiary care hospital and to analyse the allelic profiles of the clinical strains involved and the most frequent carbapenemases. DESIGN: The study analyzed cases of infection due to CRKP in the period 2013-2014; 147 cases were recorded, most of which (82.31%) were in-hospital infections. SETTING: A hospital in northern Italy. METHODS: We retrospectively collected: data on patient characteristics and the microbiological characteristics of CRKP...
September 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/27942542/carbapenem-resistant-klebsiella-pneumoniae-infection-in-three-new-york-city-hospitals-trended-downwards-from-2006-to-2014
#4
Sun O Park, Jianfang Liu, E Yoko Furuya, Elaine L Larson
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection is a rising public health threat since its first outbreaks in New York City (NYC) in the early 2000s. We investigated annual trends of CRKP infection in hospital-acquired infections (HAIs) and community-onset infections (COIs) treated in 3 NYC hospitals from 2006 to 2014. METHODS: We extracted K pneumoniae infection data including carbapenem susceptibility and anatomical sites, compared clinical characteristics between CRKP and carbapenem-susceptible K pneumoniae infections, and determined CRKP infection proportions in total K pneumoniae infections in HAI and COI to identify statistically significant trends from 2006 to 2014 using the Cochran-Armitage trend test...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27940944/colistin-resistance-in-carbapenem-resistant-klebsiella-pneumoniae-laboratory-detection-and-impact-on-mortality
#5
Laura J Rojas, Madiha Salim, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Keith S Kaye, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin
BACKGROUND: Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide. METHODS: A cohort nested within the Consortium on Resistance against Carbapenems in Klebsiella pneumoniae (CRACKLE) was constructed of patients with infection, or colonization with CRKp isolates tested for colistin susceptibility during the study period of December, 2011 to October, 2014...
December 10, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27909821/previous-bloodstream-infections-due-to-other-pathogens-as-predictors-of-carbapenem-resistant-klebsiella-pneumoniae-bacteraemia-in-colonized-patients-results-from-a-retrospective-multicentre-study
#6
D R Giacobbe, V Del Bono, P Bruzzi, S Corcione, M Giannella, A Marchese, L Magnasco, A E Maraolo, N Pagani, C Saffioti, S Ambretti, C S Cardellino, E Coppo, F G De Rosa, P Viale, C Viscoli
INTRODUCTION: the purpose of this retrospective multicenter study was to assess whether the risk of developing bloodstream infections (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP) in colonized patients is influenced by the occurrence of BSI due to other pathogens. METHODS: from January 2012 to March 2014, all patients with at least one rectal swab positive for CRKP and at least 30 days of previous hospital stay were included in the study. The primary outcome measure was CRKP BSI, defined as a time-to-event endpoint...
December 1, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27903130/risk-factors-and-mortality-in-the-carbapenem-resistant-klebsiella-pneumoniae-infection-case-control-study
#7
Fethiye Akgul, Ilkay Bozkurt, Mustafa Sunbul, Saban Esen, Hakan Leblebicioglu
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has been known as a nosocomial pathogen, both for the last 10 years in Turkey and for 20 years worldwide. Due to limited treatment options and high mortality rates, despite improvements in the field of medicine at the present time, CRKP is still a big threat for public health. This study was carried out between the dates of January 2010 and September 2014. Patients ≥18 who were hospitalized for at least 72 h and who also had CRKP growth were included in the study as a case group...
October 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27891222/epidemiology-of-klebsiella-pneumoniae-bloodstream-infections-in-a-teaching-hospital-factors-related-to-the-carbapenem-resistance-and-patient-mortality
#8
Lijun Tian, Ruoming Tan, Yang Chen, Jingyong Sun, Jialin Liu, Hongping Qu, Xiaoli Wang
BACKGROUND: Although Klebsiella pneumoniae bloodstream infections (KP-BSIs) have recently attracted attention due to an alarming raise in morbidity and mortality, there have been few reports on the epidemiology of KP-BSIs in mainland China. We sought to describe the epidemiological, microbiological, and clinical characteristics of KP-BSIs, focusing on the risk factors of carbapenem resistance and patient mortality. METHODS: A retrospective analysis of WHONET data of KP-BSI patients admitted to a teaching hospital in Shanghai, China, between January 1, 2011 and December 31, 2015 was performed, and the annual percentage of patients with carbapenem-resistant K...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27716164/carbapenem-resistant-klebsiella-pneumoniae-influences-the-outcome-of-early-infections-in-liver-transplant-recipients
#9
Francesco Barchiesi, Roberto Montalti, Pamela Castelli, Daniele Nicolini, Silvia Staffolani, Federico Mocchegiani, Alessandro Fiorentini, Esther Manso, Marco Vivarelli
BACKGROUND: Infections remain a leading cause of morbidity and mortality among liver transplant (LT) recipients. The aim of our study was to define the factors associated with outcome of early bacterial and fungal infections in a cohort of patients who underwent LT at the University Hospital of Ancona over a nine year period. METHODS: All consecutive patients who underwent LT in our center were considered. An early infection was defined as occurring in the first month post-transplantation...
October 4, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27699025/allogeneic-stem-cell-transplantation-in-a-blast-phase-chronic-myeloid-leukemia-patient-with-carbapenem-resistant-klebsiella-pneumoniae-tricuspid-valve-endocarditis-a-case-report
#10
Bulent Kantarcioglu, Huseyin Saffet Bekoz, Fatih Erkam Olgun, Beytullah Cakal, Burak Arkan, Halil Turkoglu, Ali Mert, Deniz Sargin
In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post-transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27622347/blaoxa-48-carrying-clonal-colistin-resistant-carbapenem-resistant-klebsiella-pneumoniae-in-neonate-intensive-care-unit-india
#11
Santosh Kumar Singh, Minakshi Gupta
Bacteria resistant to colistin, a last resort antibiotic reflect the pre-antibiotic era. In this study, colistin resistance carbapenem-resistant K. pneumoniae (COL(R)- CRKP) strains from neonate's intensive care unit were evaluated. Molecular analysis showed that all the four colistin resistant K. pneumoniae isolates were clonally related with strong biofilm formation ability and harbored blaSHV-34 and blaOXA-48 genes. Our result suggested the need of proper surveillance and adequate infection control to limiting the spread of these organisms...
November 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27531996/outbreak-by-ventilator-associated-st11-k-pneumoniae-with-co-production-of-ctx-m-24-and-kpc-2-in-a-sicu-of-a-tertiary-teaching-hospital-in-central-china
#12
Longhua Hu, Yanling Liu, Linqiang Deng, Qiaoshi Zhong, Yaping Hang, Zengzeng Wang, Lingling Zhan, Liangxing Wang, Fangyou Yu
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) often responsible for numerous hospital-associated outbreaks has become an important public health problem. From January 2013 to February 2014, a total of 41 non-duplicate K. pneumoniae isolates with carbapenem resistance, were collected at a tertiary teaching hospital in Nanchang, central China. Among 41 K. pneumoniae isolates, 28 were isolated from hospitalized patients including 19 from the patients in surgery intensive care unit (SICU) and 13 were isolated from ventilators...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27441063/epidemiology-of-carbapenem-resistant-klebsiella-pneumoniae-infections-in-mediterranean-countries
#13
REVIEW
Corrado Girmenia, Alessandra Serrao, Martina Canichella
Infections by Carbapenem-Resistant Enterobacteriaceae (CRE), in particular, carbapenem-resistant Klebsiella pneumoniae (CRKp), are a significant public health challenge worldwide. Resistance to carbapenems in enterobacteriaceae is linked to different mechanisms, including the production of the various types of enzymes like KPC, VIM, IMP, NDM, and OXA-48. Despite several attempts to control the spread of these infections at the local and national level, the epidemiological situation for CRKp had worsened in the last years in the Mediterranean area...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27428072/bloodstream-infections-caused-by-klebsiella-pneumoniae-in-onco-hematological-patients-clinical-impact-of-carbapenem-resistance-in-a-multicentre-prospective-survey
#14
Enrico Maria Trecarichi, Livio Pagano, Bruno Martino, Anna Candoni, Roberta Di Blasi, Gianpaolo Nadali, Luana Fianchi, Mario Delia, Simona Sica, Vincenzo Perriello, Alessandro Busca, Franco Aversa, Rosa Fanci, Lorella Melillo, Federica Lessi, Maria Ilaria Del Principe, Chiara Cattaneo, Mario Tumbarello
The aim of this study was to identify risk factors for mortality in patients suffering from hematological malignancies (HMs) with bloodstream infections (BSIs) caused by Klebsiella pneumoniae (KP). We conducted a prospective cohort study on KP BSI in 13 Italian hematological units participating in the HEMABIS registry-SEIFEM group. The outcome measured was death within 21 days of BSI onset. Survivor and non-survivor subgroups were compared and Cox regression analysis was conducted to identify independent predictors of mortality...
November 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27239799/rapid-identification-of-klebsiella-pneumoniae-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-and-detection-of-meropenem-resistance-by-flow-cytometric-assay
#15
Abdullah Kilic, Eyup Dogan, Sinem Kaya, Sema Oren, Duran Tok, Nurittin Ardic, Mehmet Baysallar
BACKGROUND: The aim of this study was to develop a rapid detection method of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains both MALDI-TOF MS and flow cytometry (FCM). METHODS: A total of 174 K. pneumoniae strains were included in this study. Molecular characterization of carbapenemase gene was performed by PCR. Bacterial identification was performed by MALDI-TOF-MS. Meropenem susceptibility was tested at the concentrations of breakpoints described by the Clinical and Laboratory Standards Institute (CLSI) guide by FCM...
November 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27206024/molecular-epidemiology-of-carbapenem-resistant-klebsiella-pneumoniae-in-greece
#16
Theodoros Karampatakis, Charalampos Antachopoulos, Elias Iosifidis, Athanassios Tsakris, Emmanuel Roilides
Hospital infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) constitute a worldwide problem associated with high rates of treatment failure and mortality. In Greece, CRKP have emerged in 2002 due to VIM carbapenemase production and later due to KPC, NDM and OXA-48-like carbapenemases that have become endemic. The molecular epidemiology of CRKP strains is dynamic, as antibiotic consumption and worldwide traveling are strongly associated with global spread of CRKP isolates. Lately, porin defects, such as disruption of OmpK35 and production of OmpK36 variant, have also contributed to carbapenem resistance...
June 2016: Future Microbiology
https://www.readbyqxmd.com/read/27044555/combination-regimens-for-treatment-of-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infections
#17
A Gomez-Simmonds, B Nelson, D P Eiras, A Loo, S G Jenkins, S Whittier, D P Calfee, M J Satlin, C J Kubin, E Y Furuya
Previous studies reported decreased mortality in patients with carbapenemase-producing Klebsiella pneumoniae bloodstream infections (BSIs) treated with combination therapy but included carbapenem-susceptible and -intermediate isolates, as per revised CLSI breakpoints. Here, we assessed outcomes in patients with BSIs caused by phenotypically carbapenem-resistant K. pneumoniae (CRKP) according to the number of in vitro active agents received and whether an extended-spectrum beta-lactam (BL) antibiotic, including meropenem, or an extended-spectrum cephalosporin was administered...
June 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27031451/a-retrospective-study-of-risk-factors-for-carbapenem-resistant-klebsiella-pneumoniae-acquisition-among-icu-patients
#18
Yangmin Hu, Yanting Ping, Leiqing Li, Huimin Xu, Xiaofeng Yan, Haibin Dai
INTRODUCTION: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is rapidly emerging as a life-threatening nosocomial infection. In this study, we aim to identify risk factors, especially antibiotic use, for CRKP infection among intensive care unit (ICU) patients. METHODOLOGY: This was a matched case-control study of a 67-bed ICU in a tertiary care teaching hospital from 1 January 2011 through 30 June 2013. The control cases were selected among the patients with carbapenem-susceptible Klebsiella pneumoniae (CSKP) and were matched with CRKP cases for year of ICU admission and site of infection...
March 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/26885543/risk-factors-and-outcomes-for-carbapenem-resistant-klebsiella-pneumoniae-isolation-stratified-by-its-multilocus-sequence-typing-st258-versus-non-st258
#19
Sorabh Dhar, Emily T Martin, Paul R Lephart, John P McRoberts, Teena Chopra, Timothy T Burger, Ruthy Tal-Jasper, Kayoko Hayakawa, Hadas Ofer-Friedman, Tsilia Lazarovitch, Ronit Zaidenstein, Federico Perez, Robert A Bonomo, Keith S Kaye, Dror Marchaim
A "high risk" clone of carbapenem-resistant Klebsiella pneumoniae (CRKP) identified by multilocus sequence typing (MLST) as sequence type (ST) 258 has disseminated worldwide. As the molecular epidemiology of the CRE pandemic continues to evolve, the clinical impact of non-ST258 strains is less well defined. We conducted an epidemiological investigation of CRKP based on strains MLST. Among 68 CRKP patients, 61 were ST258 and 7 belonged to non-ST258. Klebsiella pneumoniae ST258 strains were significantly associated with bla KPC production and with resistance to an increased number of antimicrobials...
January 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26850824/spectrum-of-excess-mortality-due-to-carbapenem-resistant-klebsiella-pneumoniae-infections
#20
MULTICENTER STUDY
C Hauck, E Cober, S S Richter, F Perez, R A Salata, R C Kalayjian, R R Watkins, N M Scalera, Y Doi, K S Kaye, S Evans, V G Fowler, R A Bonomo, D van Duin
Patients infected or colonized with carbapenem-resistant Klebsiella pneumoniae (CRKp) are often chronically and acutely ill, which results in substantial mortality unrelated to infection. Therefore, estimating excess mortality due to CRKp infections is challenging. The Consortium on Resistance against Carbapenems in K. pneumoniae (CRACKLE) is a prospective multicenter study. Here, patients in CRACKLE were evaluated at the time of their first CRKp bloodstream infection (BSI), pneumonia or urinary tract infection (UTI)...
June 2016: Clinical Microbiology and Infection
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