Tomohiko Ishibashi, Tadakatsu Inagaki, Makoto Okazawa, Akiko Yamagishi, Keiko Ohta-Ogo, Ryotaro Asano, Takeshi Masaki, Yui Kotani, Xin Ding, Tomomi Chikaishi-Kirino, Noriko Maedera, Manabu Shirai, Kinta Hatakeyama, Yoshiaki Kubota, Tadamitsu Kishimoto, Yoshikazu Nakaoka
Pulmonary arterial hypertension (PAH) is characterized by stenosis and occlusions of small pulmonary arteries, leading to elevated pulmonary arterial pressure and right heart failure. Although accumulating evidence shows the importance of interleukin (IL)-6 in the pathogenesis of PAH, the target cells of IL-6 are poorly understood. Using mice harboring the floxed allele of gp130 , a subunit of the IL-6 receptor, we found substantial Cre recombination in all hematopoietic cell lineages from the primitive hematopoietic stem cell level in SM22α-Cre mice...
April 16, 2024: Proceedings of the National Academy of Sciences of the United States of America