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Antibacterial resistance

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https://www.readbyqxmd.com/read/29334366/modified-colistin-regimen-for-critically-ill-patients-with-acute-renal-impairment-and-continuous-renal-replacement-therapy
#1
Pierantonio Menna, Emanuela Salvatorelli, Alessia Mattei, Dario Cappiello, Giorgio Minotti, Massimiliano Carassiti
Colistin is a last resort antibiotic to treat multidrug-resistant Gram-negative bacteria infections. Colistin is administered intravenously in the form of its inactive prodrug colistin methanesulfonate (CMS). For patients with acute kidney impairment and continuous renal replacement therapy high extracorporeal clearance may cause a substantial removal of active colistin from the bloodstream, eventually decreasing its antibacterial efficacy. Currently recommended doses of CMS may therefore be inadequate for these patients...
December 22, 2017: Chemotherapy
https://www.readbyqxmd.com/read/29333738/antibacterial-and-antifungal-activity-of-poly-lactic-acid-bovine-lactoferrin-nanofiber-membranes
#2
Raul Machado, André da Costa, Dina M Silva, Andreia C Gomes, Margarida Casal, Vitor Sencadas
Antimicrobial materials have become relevant for local therapies preventing microbial resistance induced by systemic antibiotic treatments. This work reports the development of electrospun poly(lactic acid) (PLLA) nanofiber membranes loaded with bovine lactoferrin (bLF) up to 20 wt%. The membranes present smooth and nondefective fibers with mean diameters between 717 ± 197 and 495 ± 127 nm, and an overall porosity of ≈80%. The hydrophobicity of the PLLA membranes is reduced by the presence of bLF. The release profile of bLF correlates with an anomalous transport model, with 17...
January 15, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29332383/developing-pantetheinase-resistant-pantothenamide-antibacterials-structural-modification-impacts-on-pank-interaction-and-mode-of-action
#3
Leanne Barnard, Konrad Johannes Mostert, Willem A L van Otterlo, Erick Strauss
Pantothenamides (PanAms) are analogues of pantothenate, the biosynthetic precursor of coenzyme A (CoA), and show potent antimicrobial activity against several bacteria and the malaria parasite in vitro. However, pantetheinase enzymes that normally degrade pantetheine in human serum also act on the PanAms, thereby reducing their potency. In this study, we designed analogues of the known antibacterial PanAm N-heptylpantothenamide (N7-Pan) to be resistant to pantetheinase by using three complementary structural modification strategies...
January 14, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29329747/antibacterial-properties-of-latarcin-1-derived-cell-penetrating-peptides
#4
Deepthi Poornima Budagavi, Archana Chugh
Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) share certain physicochemical parameters such as amphipathicity, hydrophobicity, cationicity and pI, due to which these two groups of peptides also exhibit overlapping functional characteristics. In our current work, we have evaluated antimicrobial properties of cell-penetrating peptides derived from Latarcin1. Latarcin derived peptide (LDP) exhibited antimicrobial activity against representative microorganisms tested and bactericidal effect against methicillin resistant Staphylococcus aureus (MRSA), which was used as model organism of study in the present work...
January 9, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29329652/three-new-anthraquinone-derivatives-isolated-from-symplocos-racemosa-and-their-antibiofilm-activity
#5
Umar Farooq, Sara Khan, Sadia Naz, Ajmal Khan, Afsar Khan, Ayaz Ahmed, Abdur Rauf, Syed Majid Bukhari, Shujaat Ali Khan, Arfa Kamil, Nadia Riaz, Abdur Rahman Khan
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, 1H- and 13C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL-1 against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29327181/correction-to-promising-antibacterial-effects-of-silver-nanoparticle-loaded-tea-tree-oil-nanoemulsion-a-synergistic-combination-against-resistance-threat
#6
Roqya Najafi-Taher, Behnaz Ghaemi, Sharmin Kharrazi, Samira Rasoulikoohi, Amir Amani
With regrets, there is an error in the name of one of the authors which has only been noticed after publication.
January 11, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29325916/proanthocyanidin-polymeric-tannins-from-stryphnodendron-adstringens-are-effective-against-fluconazole-resistant-candida-spp-and-treat-vaginal-candidiasis
#7
Aline Luiza Duarte de Freitas, Vanessa Kaplum, Diego Conrado Pereira Rossi, Leandro Buffoni Roque da Silva, Márcia de Souza Carvalho Melhem, Carlos Pelleschi Taborda, João Carlos Palazzo de Mello, Celso Vataru Nakamura, Kelly Ishida
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Stryphnodendron adstringens (Mart.) Coville is popularly used as anti-inflammatory, astringent and in the treatment of wounds and vaginal infections. Several pharmacological activities have been scientifically proven by "in vitro" and "in vivo" experimental assays for antibacterial, antiviral, antiprotozoan, anti-inflammatory and antioxidant. AIM OF THE STUDY: We investigated whether proanthocyanidin polymeric tannins from the Stryphnodendron adstringens steam bark with antifungal activity against Candida albicans in vitro are also active against planktonic and biofilm cells of Candida non-albicans (CNA, including fluconazole-resistant isolates) and are capable of controlling Candida vaginitis in vivo...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29325762/assessment-of-in-vivo-efficacy-of-eravacycline-against-enterobacteriaceae-exhibiting-various-resistance-mechanisms-a-dose-ranging-study-and-pk-pd-analysis
#8
Abrar K Thabit, Marguerite L Monogue, Joseph V Newman, David P Nicolau
After the pharmacokinetic (PK) profile of eravacycline as a novel fluorocycline was defined, understanding its pharmacodynamic (PD) profile became essential. The aim of this study was to assess the correlation of the PK/PD index of the area under free drug concentration-time curve above the minimum inhibitory concentration (fAUC/MIC) and its magnitude with eravacycline's efficacy against Enterobacteriaceae isolates using the immunocompetent murine thigh infection model to resemble the immunocompetent environment in eravacycline's clinical trials...
January 8, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29324679/antibacterial-evaluation-and-virtual-screening-of-new-thiazolyl-triazole-schiff-bases-as-potential-dna-gyrase-inhibitors
#9
Cristina Nastasă, Dan C Vodnar, Ioana Ionuţ, Anca Stana, Daniela Benedec, Radu Tamaian, Ovidiu Oniga, Brînduşa Tiperciuc
The global spread of bacterial resistance to drugs used in therapy requires new potent and safe antimicrobial agents. DNA gyrases represent important targets in drug discovery. Schiff bases, thiazole, and triazole derivatives are considered key scaffolds in medicinal chemistry. Fifteen thiazolyl-triazole Schiff bases were evaluated for their antibacterial activity, measuring the growth inhibition zone diameter, the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC), against Gram-positive (Staphylococcus aureus, Listeria monocytogenes) and Gram-negative (Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa) bacteria...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29323229/facile-synthesis-of-tio2-zro2-nanofibers-nitrogen-co-doped-activated-carbon-to-enhance-the-desalination-and-bacterial-inactivation-via-capacitive-deionization
#10
Ahmed S Yasin, Ibrahim M A Mohamed, Hamouda M Mousa, Chan Hee Park, Cheol Sang Kim
Capacitive deionization, as a second generation electrosorption technique to obtain water, is one of the most promising water desalination technologies. Yet; in order to achieve high CDI performance, a well-designed structure of the electrode materials is needed, and is in high demand. Here, a novel composite nitrogen-TiO2/ZrO2 nanofibers incorporated activated carbon (NACTZ) is synthesized for the first time with enhanced desalination efficiency as well as disinfection performance towards brackish water. Nitrogen and TiO2/ZrO2 nanofibers are used as the support of activated carbon to improve its low capacitance and hydrophobicity, which had dramatically limited its adequacy during the CDI process...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322242/utility-of-fosfomycin-as-antibacterial-prophylaxis-in-patients-with-hematologic-malignancies
#11
Tanya Zapolskaya, Sarah Perreault, Dayna McManus, Jeffrey E Topal
PURPOSE: Prolonged and profound neutropenia is common among hematology and hematopoietic stem cell transplant (HSCT) patients as a result of chemotherapy. The National Comprehensive Cancer Network (NCCN) and Infectious Diseases Society of America (IDSA) currently recommend antibacterial prophylaxis in patients who are deemed at intermediate or high risk for infection. Specifically, fluoroquinolone prophylaxis should be considered for high-risk neutropenic patients. However, with prolonged and frequent exposure to fluoroquinolones, these high-risk patients may develop resistance to these agents...
January 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29321997/ascertainment-of-pharmacological-activities-of-allamanda-neriifolia-hook-and-aegialitis-rotundifolia-roxb-used-in-bangladesh-an-in%C3%A2-vitro-study
#12
Imam Hasan, Md Saddam Hussain, Md Shalahuddin Millat, Niloy Sen, Md Abdur Rahman, Md Atikur Rahman, Safiqul Islam, Md Mizanur Rahman Moghal
The present study was cherished to investigate in vitro thrombolytic, membrane stabilizing and antibacterial activities of Allamanda neriifolia and Aegialitis rotundifolia. Different types methanolic extracts of these two medicinal plants were tested for determining membrane stabilizing activity at a hypotonic solution and heat induce condition by comparing with reference standard acetyl salicylic acid (0.10 mg/mL), where thrombolytic activity assessment was done by employing Streptokinase as standard drug...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321009/dual-action-of-highbush-blueberry-proanthocyanidins-on-aggregatibacter-actinomycetemcomitans-and-the-host-inflammatory-response
#13
Amel Ben Lagha, Geneviève LeBel, Daniel Grenier
BACKGROUND: The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence properties of Aggregatibacter actinomycetemcomitans and macrophage-associated inflammatory responses. METHODS: PACs were isolated from frozen highbush blueberries using solid-phase chromatography. A microplate dilution assay was performed to determine the effect of highbush blueberry PACs on A...
January 10, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29320762/corrected-and-republished-from-identification-of-peptidoglycan-hydrolase-constructs-with-synergistic-staphylolytic-activity-in-cow-s-milk
#14
Carolin T Verbree, Steven M Dätwyler, Susanne Meile, Fritz Eichenseher, David M Donovan, Martin J Loessner, Mathias Schmelcher
Peptidoglycan hydrolases (PGHs) have been suggested as novel therapeutics for the treatment of bovine mastitis. However, activity in the presence of cow's milk is an important requirement for drugs administered into the bovine udder. We have used a microtiter plate-based protocol to screen a library of >170 recombinant PGHs, including engineered bacteriophage endolysins, for enzymes with activity against Staphylococcus aureus in milk. Eight suitable PGH constructs were identified by this approach, and their efficacies against S...
January 1, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29320234/influence-of-soap-characteristics-and-food-service-facility-type-on-the-degree-of-bacterial-contamination-of-open-refillable-bulk-soaps
#15
Donald W Schaffner, Dane Jensen, Charles P Gerba, David Shumaker, James W Arbogast
Concern has been raised regarding the public health risks from refillable bulk-soap dispensers because they provide an environment for potentially pathogenic bacteria to grow. This study surveyed the microbial quality of open refillable bulk soap in four different food establishment types in three states. Two hundred ninety-six samples of bulk soap were collected from food service establishments in Arizona, New Jersey, and Ohio. Samples were tested for total heterotrophic viable bacteria, Pseudomonas, coliforms and Escherichia coli, and Salmonella...
January 10, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29319507/inhibition-of-multidrug-resistant-gram-positive-and-gram-negative-bacteria-by-a-photoactivated-porphyrin
#16
Moreno Bondi, Anna Mazzini, Simona de Niederhäusern, Ramona Iseppi, Patrizia Messi
The authors studied the in vitro antibacterial activity of the photo-activated porphyrin meso-tri(N-methyl-pyridyl), mono(N-tetradecyl-pyridyl)porphine (C14) against four multidrug-resistant bacteria: Staphylococcus aureus, Enterococcus faecalis (Gram-positive), Escherichia coli, Pseudomonas aeruginosa (Gram-negative). Using 10 μg/ml of porphyrin and 60 sec irradiation we observed the remarkable susceptibility of S. aureus and E. faecalis to treatment while, under the same conditions, E. coli and P. aeruginosa showed very low susceptibility...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29319372/synchronous-application-of-antibiotics-and-essential-oils-dual-mechanisms-of-action-as-a-potential-solution-to-antibiotic-resistance
#17
Lucy Owen, Katie Laird
Antibiotic resistance has increased dramatically in recent years, yet the antibiotic pipeline has stalled. New therapies are therefore needed to continue treating antibiotic resistant infections. One potential strategy currently being explored is the use of non-antibiotic compounds to potentiate the activity of currently employed antibiotics. Many natural products including Essential Oils (EOs) possess broad spectrum antibacterial activity and so have been investigated for this purpose. This article aims to review recent literature concerning the antibacterial activity of EOs and their interactions with antibiotics, with consideration of dual mechanisms of action of EOs and antibiotics as a potential solution to antibiotic resistance...
January 10, 2018: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/29318401/synthesis-anti-microbial-activity-cytotoxicity-of-some-novel-substituted-5-3-1h-benzo-d-imidazol-2-yl-4-hydroxybenzyl-benzofuran-2-yl-phenyl-methanone-analogs
#18
Bhookya Shankar, Pochampally Jalapathi, Balabadra Saikrishna, Shaym Perugu, Vijjulatha Manga
BACKGROUND: There is a dire need for the discovery and development of new antimicrobial agents after several experiments for a better resistance of microorganisms towards antimicrobial agents become a serious health problem for a few years in the past. As benzimidazole possess various types of biological activities, it has been synthesized, in the present study, a new series of (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs by using the condensation and screened for its in vitro antimicrobial activity and cytotoxicity...
January 9, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29317818/antibacterial-mechanisms-of-a-novel-type-picosecond-laser-generated-silver-titanium-nanoparticles-and-their-toxicity-to-human-cells
#19
Peri Korshed, Lin Li, Zhu Liu, Aleksandr Mironov, Tao Wang
In this study, we explored the antibacterial mechanisms for a novel type of Ag-TiO2 compound nanoparticles (NPs) produced from an Ag-TiO2 alloy using a picosecond laser and evaluated the toxicity of the Ag-TiO2 NPs to a range of human cell types. Transmission electron microscopy was used to determine the morphology, shapes, and size distribution of the laser-generated Ag-TiO2 NPs. UV-visible spectrometer was used to confirm the shift of light absorbance of the NPs toward visible light wavelength. Results showed that the laser-generated Ag-TiO2 NPs had significant antibacterial activities against both Gram-negative and Gram-positive bacterial strains, including Escherichia coli, Pseudomonas aeruginosa, and the methicillin-resistant Staphylococcus aureus...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29317817/antibacterial-activity-of-trimetal-cuznfe-oxide-nanoparticles
#20
Khalid E Alzahrani, Abdurahman A Niazy, Abdullah M Alswieleh, Rizwan Wahab, Ahmed M El-Toni, Hamdan S Alghamdi
Background: The increasing resistance of pathogenic bacteria to antibiotics is a challenging worldwide health problem that has led to the search for new and more efficient antibacterial agents. Nanotechnology has proven to be an effective tool for the fight against bacteria. Methods: In this paper, we present the synthesis and traits of trimetal (CuZnFe) oxide nanoparticles (NPs) using X-ray diffraction, high-resolution transmission electron microscopy, and energy dispersive x-ray spectroscopy...
2018: International Journal of Nanomedicine
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