keyword
https://read.qxmd.com/read/38454369/health-facility-assessment-of-small-and-sick-newborn-care-in-low-and-middle-income-countries-systematic-tool-development-and-operationalisation-with-nest360-and-unicef
#21
JOURNAL ARTICLE
Rebecca E Penzias, Christine Bohne, Samuel K Ngwala, Evelyn Zimba, Norman Lufesi, Ekran Rashid, Edith Gicheha, Opeyemi Odedere, Olabisi Dosunmu, Robert Tillya, Josephine Shabani, James H Cross, Sara Liaghati-Mobarhan, Msandeni Chiume, George Banda, Alfred Chalira, John Wainaina, David Gathara, Grace Irimu, Steve Adudans, Femi James, Olukemi Tongo, Veronica Chinyere Ezeaka, Georgina Msemo, Nahya Salim, Louise T Day, Timothy Powell-Jackson, Jaya Chandna, Maureen Majamanda, Elizabeth M Molyneux, Maria Oden, Rebecca Richards-Kortum, Eric O Ohuma, Chris Paton, Tedbabe Hailegabriel, Gagan Gupta, Joy E Lawn
BACKGROUND: Each year an estimated 2.3 million newborns die in the first 28 days of life. Most of these deaths are preventable, and high-quality neonatal care is fundamental for surviving and thriving. Service readiness is used to assess the capacity of hospitals to provide care, but current health facility assessment (HFA) tools do not fully evaluate inpatient small and sick newborn care (SSNC). METHODS: Health systems ingredients for SSNC were identified from international guidelines, notably World Health Organization (WHO), and other standards for SSNC...
March 7, 2024: BMC Pediatrics
https://read.qxmd.com/read/38452478/resource-setting-impacts-neonatal-but-not-maternal-survival-in-bitches-treated-for-dystocia-243-cases-2015-2020
#22
JOURNAL ARTICLE
Cece Zhu, Clare L Timothy, Emily McCobb, Elizabeth A Rozanski, Gretchen L Schoeffler
OBJECTIVE: To compare maternal and fetal outcomes of dystocia managed surgically and nonsurgically at referral hospitals (RHs) versus community medicine clinics (CMCs), determine the rate of C-section, and evaluate the incidence of hypoglycemia and hypocalcemia in bitches presented with dystocia. ANIMALS: Bitches presented with dystocia at 2 RHs and 2 CMCs. METHODS: Information on signalment, presence of hypoglycemia and/or hypocalcemia, diagnostic imaging performed, nonsurgical and surgical interventions performed, maternal and fetal outcomes, and total cost of care was obtained from the electronic medical records of bitches presenting for dystocia between October 2015 and October 2020...
March 7, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38447952/continuous-neuromuscular-blockade-for-bronchopulmonary-dysplasia
#23
JOURNAL ARTICLE
Emily D Johnson, Kristopher Keppel, LeAnn McNamara, Joseph M Collaco, Renee D Boss
OBJECTIVE:  Bronchopulmonary dysplasia (BPD) is the most common late morbidity for premature infants. Continuous neuromuscular blockade (CNMB) is suggested for the most unstable phase of BPD, despite no outcome data. We explored the association between duration of CNMB for severe BPD and mortality. DESIGN:  Medical record review of children <5 years old admitted from 2016 to 2022 with BPD and one or more course of CNMB for ≥14 days. RESULTS:  Twelve children received a total of 20 episodes of CNMB for ≥14 days (range 14-173 d) during their hospitalization...
March 6, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38442954/outcomes-following-the-adoption-of-standard-parenteral-nutrition-in-preterm-infants-a-whole-population-non-concurrent-control-study
#24
JOURNAL ARTICLE
Jessica Burgess-Shannon, Mohammad Chehrazi, Julia Lanoue, Neena Modi, Sabita N Uthaya
OBJECTIVE: To evaluate the impact of a quality improvement project of the adoption of standard parenteral nutrition (SPN) in preterm infants. DESIGN: Retrospective, multicentre, whole-population, non-concurrent control study using data from the UK National Neonatal Research Database between 1 January 2014 and 31 December 2020. SETTING: Neonatal units in London UK organised by geographical network. PATIENTS: Preterm infants <31 weeks' gestation...
March 4, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38441196/role-of-bacteria-and-microbial-metabolites-in-immune-modulation-during-early-life
#25
JOURNAL ARTICLE
Tine Simensen Oldereid, Xiaojun Jiang, Kathrine Sivertsen Nordhus, Andrea Ponzetta, Jørgen Vildershøj Bjørnholt, Niklas K Björkström, Espen Melum, Henrik Rasmussen
Host-microbiome interplay from birth is essential for immune imprinting and tuning. Live gut microbes and microbial-derived metabolites regulate the development and modulation of the immune system, but whether microbial metabolites solely are sufficient to induce immune maturation remains unclear. Sterile faecal filtrates (FFT) were generated from murine gut contents. Newborn germ-free (GF) mice were treated twice daily with FFT (GF-FFT) or saline (GF-NaCl) from post-natal day 5 until 4 weeks of age...
February 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38438723/clinical-features-of-recurrent-preeclampsia-a-retrospective-study-of-109-recurrent-preeclampsia-patients
#26
JOURNAL ARTICLE
Shujie Han, Hui Zhang, Yingdong He, Qian Chen
Our study aimed to investigate the clinical features of recurrent preeclampsia (rPE) and evaluate the preventive effect of low-dose aspirin (LDA) in rPE. We retrospectively analyzed the data of 109 patients who experienced preeclampsia in two consecutive pregnancies and delivered at Peking University First Hospital from January 2016 to December 2022. We analyzed the pregnancy outcomes of patients with rPE and assessed whether the use of LDA during pregnancy could improve these outcomes. Our results revealed that patients with rPE had a higher body mass index (BMI) and a higher incidence of diabetes during pregnancy compared to their first onset of preeclampsia (29...
March 4, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38438604/cdc-like-kinase-3-deficiency-aggravates-hypoxia-induced-cardiomyocyte-apoptosis-through-akt-signaling-pathway
#27
JOURNAL ARTICLE
Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhen
Hypoxia-induced cardiomyocyte apoptosis is one major pathological change of acute myocardial infarction (AMI), but the underlying mechanism remains unexplored. CDC-like kinase 3 (CLK3) plays crucial roles in cell proliferation, migration and invasion, and nucleotide metabolism, however, the role of CLK3 in AMI, especially hypoxia-induced apoptosis, is largely unknown. The expression of CLK3 was elevated in mouse myocardial infarction (MI) models and neonatal rat ventricular myocytes (NRVMs) under hypoxia. Furthermore, CLK3 knockdown significantly promoted apoptosis and inhibited NRVM survival, while CLK3 overexpression promoted NRVM survival and inhibited apoptosis under hypoxic conditions...
March 4, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38437954/long-term-outcome-after-neonatal-intervention-for-congenital-critical-aortic-stenosis
#28
JOURNAL ARTICLE
Beatrice Bonello, Richard Issitt, Marina Hughes, Michelle Carr, Xavier Iriart, Sachin Khambadkone, Alessandro Giardini, Martin Kostolny, Jan Marek
BACKGROUND: This study explored long-term outcome and functional status of patients born with critical aortic stenosis (CAS) following neonatal surgical or catheter interventions. METHODS: A 40-year retrospective review of all consecutive patients within a large, single-center referral unit who required neonatal (<30 days) intervention for CAS. Additional detailed evaluation of surviving patients >7 years age was performed, with clinical assessment, objective cardiopulmonary exercise testing and state-of-the-art characterization of myocardial function (advanced echocardiography and cardiac MRI)...
March 2, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38437802/association-between-intermittent-hypoxemia-and-nicu-length-of-stay-in-preterm-infants
#29
JOURNAL ARTICLE
Anna Maria Hibbs, Zhengyi Chen, Nori M Minich, Richard J Martin, Thomas M Raffay, Peter M MacFarlane, Juliann M Di Fiore
INTRODUCTION: Length of hospitalization varies widely in preterm infants and can be affected by multiple maternal and neonatal factors including respiratory instability. Therefore, we aimed to determine the association between postnatal intermittent hypoxemia (IH) and prolonged hospitalization. METHODS: This prospective single-center cohort study followed infants born at &lt;31 weeks of gestational age through 2 years corrected age with detailed oxygen saturation data captured from days 7 to 30 of age...
March 4, 2024: Neonatology
https://read.qxmd.com/read/38436999/biochemical-properties-of-sheep-colostrum-and-its-potential-benefits-for-lamb-survival-a-review
#30
REVIEW
Umar Farooq, Sohail Ahmed, Guiqiong Liu, Xunping Jiang, Huiguo Yang, Jianping Ding, Mehboob Ali
Colostrum is the initial secretion of the mammary glands following parturition, which offers main food, protection, and biological active substances for the new born. The most threatening episode of neonate's life is the initial two weeks after birth. This period is associated with high neonatal mortality and morbidity. These worthwhile losses lead to a poor prolificacy rate, low profitability, and ultimately poor performance in animal production. Hence, both diseases and mortality cause valuable losses in terms of production and economic losses...
March 4, 2024: Animal Biotechnology
https://read.qxmd.com/read/38435960/rescue-cerclage-by-mcdonald-s-technique-at-18-weeks-for-cervical-insufficiency-with-intravaginal-amniotic-sac-a-case-report
#31
Pankaj Salvi, Vidya Gaikwad, Ashton Dsouza, Sravani Ankem
Recurrent pregnancy loss, premature birth, and associated complications exhibit a multifactorial etiology and persist as substantial challenges during pregnancy, despite the notable advancements in the medical field. Among several factors, cervical insufficiency or incompetence emerges as a prominent causal factor, characterized by painless softening and shortening of the cervix associated with absent contractions. The implementation of emergency cerclage represents a pivotal intervention in mitigating preterm birth among individuals with advanced cervical insufficiency...
January 2024: Curēus
https://read.qxmd.com/read/38435156/presurgical-use-of-hypoxic-mixture-for-systemic-perfusion-improvement-in-neonates-with-complex-congenital-heart-disease-a-systematic-review-and-meta-analysis
#32
REVIEW
Delia E Theurel Martín, Jorge L Alvarado Socarras, Edgar F Manrique Hernández, Mónica A Sandoval, Alvaro J Coronado Munoz
Oxygen therapy is essential for the survival of preterm babies and critically ill newborns; however, it has the potential to cause harm through hypoxemia or hyperoxemia. Newborns with complex congenital heart diseases (CHD) suffer from oxygen fluctuations due to the disease and its treatments, altering pre and postnatal development. The objective of this study is to evaluate the evidence for using a hypoxic mixture to decrease pulmonary over-circulation and improve systemic perfusion before surgical interventions in newborns with complex CHD that course with pulmonary over-circulation and systemic hypoperfusion...
February 2024: Curēus
https://read.qxmd.com/read/38434140/modulating-embryonic-signaling-pathways-paves-the-way-for-regeneration-in-wound-healing
#33
REVIEW
Sophie Frech, Beate M Lichtenberger
Epithelial tissues, including the skin, are highly proliferative tissues with the capability to constant renewal and regeneration, a feature that is essential for survival as the skin forms a protective barrier against external insults and water loss. In adult mammalian skin, every injury will lead to a scar. The scar tissue that is produced to seal the wound efficiently is usually rigid and lacks elasticity and the skin's original resilience to external impacts, but also secondary appendages such as hair follicles and sebaceous glands...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38433292/two-year-neurodevelopmental-outcome-in-extremely-preterm-born-children-the-austrian-preterm-outcome-study-group
#34
JOURNAL ARTICLE
Ursula Kiechl-Kohlendorfer, Burkhard Simma, Angelika Berger, Berndt Urlesberger, Martin Wald, Nadja Haiden, Renate Fuiko, Jean-Pierre Ndayisaba
AIM: The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years of age. METHODS: All live-born infants 23-27 weeks of gestation born between 2011 and 2020 in Austria were included in a prospective registry. Neurodevelopmental outcome at 2 years of corrected age was assessed using Bayley Scales of Infant Development for both motor and cognitive scores, along with a neurological examination and an assessment of neurosensory function...
March 3, 2024: Acta Paediatrica
https://read.qxmd.com/read/38433271/risk-factors-associated-with-neonatal-mortality-among-neonates-admitted-to-neonatal-intensive-care-unit-of-the-university-teaching-hospital-in-lusaka
#35
JOURNAL ARTICLE
Deborah Tembo, Francis D N Abobo, Patrick Kaonga, Choolwe Jacobs, Barnabas Bessing
Globally, several children die shortly after birth and many more of them within the first 28 days of life. Sub-Sharan Africa accounts for almost half (43%) of the global neonatal death with slow progress in reduction. These neonatal deaths are associated with lack of quality care at or immediately after birth and in the first 28 days of life. This study aimed to determine the trends and risk factors of facility-based neonatal mortality in a major referral hospital in Lusaka, Zambia. We conducted retrospective analysis involving all neonates admitted in the University Teaching Hospital Neonatal Intensive Care Unit (UTH-NICU) in Lusaka from January 2018 to December 2019 (N = 2340)...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38432888/clinical-characteristics-of-bronchopulmonary-dysplasia-in-very-preterm-infants
#36
JOURNAL ARTICLE
Yonghui Yang, Xiaori He, Xuefei Zhang, Pingyang Chen
OBJECTIVES: With the development of perinatal and neonatal intensive care medicine, the survival rate of very premature infants increases year by year. However, the incidence of bronchopulmonary dysplasia (BPD) increases year by year, which seriously affects the survival prognosis of very premature infants. How to prevent and treat BPD effectively has become the focus of neonatologists. This study aims to provide ideas for the prevention and treatment of BPD in very preterm infants via analyzing the clinical characteristics of BPD...
October 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38432502/cellular-nucleic-acid-binding-protein-facilitates-cardiac-repair-after-myocardial-infarction-by-activating-%C3%AE-catenin-signaling
#37
JOURNAL ARTICLE
Chong Du, Shan Zhao, Tiankai Shan, Xudong Han, Qiqi Jiang, Jiawen Chen, Lingfeng Gu, Tianwen Wei, Tongtong Yang, Sibo Wang, Hao Wang, Xuejiang Guo, Liansheng Wang
The regenerative capacity of the adult mammalian heart is limited, while the neonatal heart is an organ with regenerative and proliferative ability. Activating adult cardiomyocytes (CMs) to re-enter the cell cycle is an effective therapeutic method for ischemic heart disease such as myocardial infarction (MI) and heart failure. Here, we aimed to reveal the role and potential mechanisms of cellular nucleic acid binding protein (CNBP) in cardiac regeneration and repair after heart injury. CNBP is highly expressed within 7 days post-birth while decreases significantly with the loss of regenerative ability...
March 1, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38432296/young-infant-mortality-associated-with-preterm-and-small-for-gestational-age-births-in-rural-bangladesh-a-prospective-cohort-study
#38
JOURNAL ARTICLE
Jennifer A Applegate, Md Shafiqul Islam, Rasheda Khanam, Arunangshu Dutta Roy, Nabidul Haque Chowdhury, Salahuddin Ahmed, Dipak K Mitra, Arif Mahmud, Mohammad Shahidul Islam, Samir K Saha, Abdullah H Baqui
OBJECTIVE: To assess the relative risk of mortality in preterm and small-for-gestational-age (SGA) infants during the first and second months of life in rural Bangladesh. STUDY DESIGN: We analyzed data from a cohort of pregnant women and their babies in Sylhet, Bangladesh, assembled between 2011 and 2014. Community health workers visited enrolled babies up to 10 times from birth to age 59 days. Survival status was recorded at each visit. Gestational age was estimated from mother's reported last menstrual period...
March 1, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38432196/neonatal-extracorporeal-membrane-oxygenation-associations-between-continuous-renal-replacement-therapy-thrombocytopenia-and-outcomes
#39
JOURNAL ARTICLE
Lauren R Walker, Laura E Hollinger, W Michael Southgate, David T Selewski, Jeffrey E Korte, Mathew Gregoski, Heidi J Steflik
INTRODUCTION: The incidence of thrombocytopenia in neonates receiving extracorporeal membrane oxygenation (ECMO) with and without concurrent continuous renal replacement therapy (CRRT) and associated complications have not been well described. The primary aims of the current study were to (1) characterize thrombocytopenia in neonates receiving ECMO (including treated concurrently with CRRT) and (2) evaluate risk factors (including CRRT utilization) associated with severe thrombocytopenia...
March 1, 2024: Blood Purification
https://read.qxmd.com/read/38429824/ultrasound-findings-and-specific-intrinsic-blood-volume-expansion-therapy-for-neonatal-capillary-leak-syndrome-report-from-a-multicenter-prospective-self-control-study
#40
JOURNAL ARTICLE
Jing Liu, Yue-Qiao Gao, Wei Fu
OBJECTIVE: Capillary leak syndrome (CLS) is characterized by severe systemic edema without specific treatment, resulting in a high mortality rate. This study investigated whether there is organ edema in neonatal CLS patients and specific treatment strategies to improve patient prognosis. METHODS: Thirty-seven newborns diagnosed with CLS were included in this study. (1) Routine point-of-care ultrasound (POCUS) was used to identify whether the patients had visceral edema or fluid collection...
March 1, 2024: European Journal of Medical Research
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