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Peter Cherutich, Matthew Golden, Bourke Betz, Beatrice Wamuti, Anne Ng'ang'a, Peter Maingi, Paul Macharia, Betsy Sambai, Felix Abuna, David Bukusi, Mathew Dunbar, Carey Farquhar
BACKGROUND: The utilization of routine health information systems (HIS) for surveillance of assisted partner services (aPS) for HIV in sub-Saharan is sub-optimal, in part due to poor data quality and limited use of information technology. Consequently, little is known about coverage, scope and quality of HIV aPS. Yet, affordable electronic data tools, software and data transmission infrastructure are now widely accessible in sub-Saharan Africa. METHODS: We designed and implemented a cased-based surveillance system using the HIV testing platform in 18 health facilities in Kenya...
2016: BMC Medical Informatics and Decision Making
Chikashi Yoshida, Hirohisa Nakamae, Linda Fletcher, Daisuke Koga, Takayuki Sogabe, Itaru Matsumura, Yuzuru Kanakura, Susan Branford, Tomoki Naoe
BACKGROUND: Detection and quantitation of BCR-ABL1 transcripts are crucial for managing patients with chronic myeloid leukemia (CML). Although real-time quantitative polymerase chain reaction (RT-qPCR) can be measured on an International Scale (IS), this has not become fully universal. By using a WHO international standard panel established for calibrating secondary standards based on the IS, we have previously developed an RT-qPCR kit, ODK-1201, for quantification of major BCR-ABL1. RESULTS: In this study, the reliability of kit-specific conversion factor 1...
2016: SpringerPlus
Sumiko Kobayashi, Yasunori Ueda, Yasuhito Nannya, Hirohiko Shibayama, Hideto Tamura, Kiyoyuki Ogata, Yoshiki Akatsuka, Kensuke Usuki, Yoshikazu Ito, Masaya Okada, Takahiro Suzuki, Tomoko Hata, Akira Matsuda, Kaoru Tohyama, Keiji Kakumoto, Daisuke Koga, Kinuko Mitani, Tomoki Naoe, Haruo Sugiyama, Fumimaro Takaku
BACKGROUND: This present study was designed to follow up 82 patients among 115 MDS patients registered in study ODK-0801 for 5 years, to analyze the relationship between the WT1 mRNA expression level and prognosis. OBJECTIVE: This study aimed to investigate the clinical utility of WT1 mRNA expression levels. METHODS: After study ODK-0801, we investigated the conditions of the same patients once a year, including any clinical and laboratory findings supporting the diagnosis, and treatment among the living patients...
March 31, 2016: Cancer Biomarkers: Section A of Disease Markers
Andreas Steiner, Jerry Hella, Servan Grüninger, Grace Mhalu, Francis Mhimbira, Colin I Cercamondi, Basra Doulla, Nicolas Maire, Lukas Fenner
OBJECTIVE: A software tool is developed to facilitate data entry and to monitor research projects in under-resourced countries in real-time. METHODS: The eManagement tool "odk_planner" is written in the scripting languages PHP and Python. The odk_planner is lightweight and uses minimal internet resources. It was designed to be used with the open source software Open Data Kit (ODK). The users can easily configure odk_planner to meet their needs, and the online interface displays data collected from ODK forms in a graphically informative way...
September 2016: Journal of the American Medical Informatics Association: JAMIA
Hirohisa Nakamae, Chikashi Yoshida, Yasuhiko Miyata, Michihiro Hidaka, Naokuni Uike, Daisuke Koga, Takayuki Sogabe, Itaru Matsumura, Yuzuru Kanakura, Tomoki Naoe
The current first-line therapy of chronic myeloid leukemia (CML) is based on tyrosine kinase inhibitors. Diagnostic kits that are capable of identifying at least a 4.5 log reduction in the international scale % BCR-ABL/ABL (IS % BCR-ABL/ABL) are needed for use in the clinical evaluation of deeper molecular response to treatment and to determine the timing of dose selection or treatment interruption during the course of treatment. In this study, we evaluated the performance of a new diagnostic kit, ODK-1201, designed to be capable of performing reverse transcription and quantitative PCR in a single tube for the quantitation of major BCR-ABL mRNA...
September 2015: International Journal of Hematology
Carina King, Jenny Hall, Masford Banda, James Beard, Jon Bird, Peter Kazembe, Ed Fottrell
BACKGROUND: As hardware for electronic data capture (EDC), such as smartphones or tablets, becomes cheaper and more widely available, the potential for using such hardware as data capture tools in routine healthcare and research is increasing. OBJECTIVE: We aim to highlight the advantages and disadvantages of four EDC systems being used simultaneously in rural Malawi: two for Android devices (CommCare and ODK Collect), one for PALM and Windows OS (Pendragon), and a custom-built application for Android (Mobile InterVA--MIVA)...
2014: Global Health Action
Chrispin Kabuya, Graham Wright, Anthony Odama, Don O'Mahoney
The research team needed to upsize the solution previously tested so that it could expand the routine data collected via tablet computers. The research team identified the general flow of data within clinics. Data was mainly collected from registers, which were later converted to electronic form and checked for duplication. A database was designed for the collection of demographic data (Patient Master Index), which was aimed at eliminating duplication of patients' data in several registers. Open Data Kit (ODK) Collect was setup on Android tablets for collecting disease related routine data, while ODK Aggregate as the storage and aggregates of data captured by ODK Collect and the Patient Master Index for demographic data, were setup on an Apple Mini Mac server...
2014: Studies in Health Technology and Informatics
A Raja, A Tridane, A Gaffar, T Lindquist, K Pribadi
Periodic collection of field data, analysis and interpretation of data are key to a good healthcare service. This data is used by the subsequent decision makers to recognize preventive measures, provide timely support to the affected and to help measure the effects of their interventions. While the resources required for good disease surveillance and proactive healthcare are available more readily in developed countries, the lack of these in developing countries may compromise the quality of service provided...
2014: Online Journal of Public Health Informatics
Muneki Hotomi, Akihisa Togawa, Shin Takei, Gen Sugita, Rinya Sugita, Masamitsu Kono, Yutaka Fujimaki, Yosuke Kamide, Akihiro Uchizono, Keiko Kanesada, Shoichi Sawada, Naohiro Okitsu, Yumi Tanaka, Yoko Saijo, Noboru Yamanaka
Since the incidence of penicillin-resistant Streptococcus pneumoniae has been increasing at an astonishing rate throughout the world, the need for accurate and rapid identification of pneumococci has become increasingly important to determine the appropriate antimicrobial treatment. We have evaluated an immunochromatographic test (ODK-0901) that detects pneumococcal antigens using 264 middle ear fluids (MEFs) and 268 nasopharyngeal secretions (NPSs). A sample was defined to contain S. pneumoniae when optochin and bile sensitive alpha hemolytic streptococcal colonies were isolated by culture...
2012: PloS One
Kazunari Murakami, Tomoari Kamada, Hiroki Ishikawa, Hiroshi Imamura, Hiroshi Matsumoto, Minoru Fujita, Ken-Ichi Tarumi, Akiko Shiotani, Kazuhiro Mizukami, Seiji Shiota, Tadayoshi Okimoto, Masaaki Kodama, Ayako Akiyoshi, Tetsuya Oda, Atsunari Noda, Jiro Hata, Ken Haruma, Toshio Fujioka
BACKGROUND: ODK-0702 is a stick-type urinary Helicobacter pylori (H. pylori) antibodies detection kit, developed to improve the original housing type urinary H. pylori antibodies detection kit "RAPIRUN H. pylori Antibody". This stick-type kit is designed for the efficient daily medical practice at hospital or clinic, public or school health checkup, to detect H. pylori infection. The aim of this study was to evaluate the performance and correlation of this kit with the original kit and the ELISA kit...
2011: Clinical Laboratory
V F Sahach, A V Kotsiuruba, O V Baziliuk, O F Mehed', L H Stepanenko
It has been studied an action of chronic urea introduction (40 mg/kg, 14 and 28 days) as arginase inhibitor on nonoxidative (arginase activity, urea, polyamines content) and oxidative (NOS activity, nitrite- and nitrate-anion content) metabolism of L-arginine in aorta, heart, plasma and erythrocytes of SHR. It has been shown that urea is an inhibitor of not arginase only, but also ornitinedecarboxilase (ODK) reactions, limiting L-arginine consumption for urea and polyamines synthesis and thus facilitating its utilization for nitric oxide synthesis by NOS...
2004: Fiziolohichnyĭ Zhurnal
J Rybakowski, E Potok, W Strzyzewski, C Nowakowska
The active cation transport mechanisms (ouabain-dependent fluxes of sodium; ODS) and potassium (ODK), sodium-potassium adenosine triphosphatase ([Na+-K+]-ATPase) activity as well as lithium-sodium countertransport (LSC) reflecting sodium exchange diffusion, were studied in erythrocytes of forty-four patients with endogenous depression both in acute episode and in remission, and compared with thirty healthy control subjects. During depressive episodes, the activities of all mechanisms studied were significantly lower than those of control subjects...
May 1984: Clinical and Experimental Pharmacology & Physiology
L B Saltykova, M N Blinov
The content of polyamines, rate of their biosynthesis, and activity of ornithine decarboxylase (ODK), the key regulatory enzyme in the polyamine biosynthetic pathway, have been studied in the leukocytes of healthy persons and of patients with various forms of leukemia. The polyamine levels and the rate of their biosynthesis were considerably higher in lymphocytes than in granulocytes. In leukemias, as the cell population rejuvenated, both the polyamine content and the spermidine/spermine ratio were found to be markedly elevated approaching the maximal values in human blast cells of K-562 line...
1987: Eksperimentalʹnai︠a︡ Onkologii︠a︡
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