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Davide D'Amico, Thomas Gener, Maria Martínez de Lagrán, Maria V Sanchez-Vives, Mónica Santos, Mara Dierssen
The inability to properly extinguish fear memories constitutes the foundation of several anxiety disorders, including panic disorder. Recent findings show that boosting prefrontal cortex synaptic plasticity potentiates fear extinction, suggesting that therapies that augment synaptic plasticity could prove useful in rescue of fear extinction impairments in this group of disorders. Previously, we reported that mice with selective deregulation of neurotrophic tyrosine kinase receptor, type 3 expression (TgNTRK3) exhibit increased fear memories accompanied by impaired extinction, congruent with an altered activation pattern of the amygdala-hippocampus-medial prefrontal cortex fear circuit...
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Cliona Murphy, Ralph Lazzara
The sinoatrial node, or sinus node, of humans is the principal pacemaker of the heart. Over the last century, studies have unraveled the complex molecular architecture of the sinus node and the expression of unique ion channels within its specialized myocytes. Aim of this review is to describe the embriology, the anatomy, the histology and the electrophisiology of the sinus node.
June 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Dusan Vitanovics, László Bárány, Zoltán Papp, Csaba Padányi, Attila Balogh, Péter Banczerowski
BACKGROUND AND PURPOSE: Symptomatic degenerative multilevel cervical spinal stenosis--beside other methods--is often treated using the open-door laminoplasty. This procedure aims to decompress the spinal cord and preserve the stability of the cervical spine. The efficiency and safety of the method was proved by numerous Japanese and American studies, also the technique related complications are well known. We treated 43 patients with symptomatic multilevel cervical spine stenosis using the open-door laminoplasty as a surgical procedure of choice in the National Institute of Clinical Neurosciences between 2009 and 2012...
January 30, 2015: Ideggyógyászati Szemle
Guy Merlin Ngounou, Martin Kom
In this paper we present an instrumentation amplifier with discrete elements and optimized noise for the amplification of very low signals. In amplifying signals of very weak amplitude, the noise can completely absorb these signals if the used amplifier does not present the optimal guarantee to minimize the noise. Based on related research and re-viewing of recent patents Journal of Medical Systems, 30:205-209, 2006, we suggest an approach of noise reduction in amplification much more thoroughly than re-viewing of recent patents and we deduce from it the general criteria necessary and essential to achieve this optimization...
December 2014: Journal of Medical Systems
Daniele Muser, Marzia De Biasio, Luca Rebellato, Alessandro Proclemer
We describe the case of a 37-year-old woman with atrial tachycardia associated to atrial septal aneurysm. We consider a localized reentry mechanism as the pathogenetic mechanism of the arrhythmia as demostrated by means of electrophisiological evaluation and electroanatomical mapping. The treatment by radiofrequency appears as an effective and well tolerated treatment of this unusual left atrial tachycardia.
September 2011: Journal of Cardiovascular Medicine
Anna Swierczyńska, Renata Kłusek, Marek Kaciński
THE AIM OF THE STUDY: Epilepsy in the developmental age is connected in some cases with disorders of gross motor dysfunction, but in the others every day motor activity is not disturbed. Although it does not mean that in children with epilepsy there are not diagnosed any different motor disorders. Aim of the study was to determined the differences between epilepsy with and without gross motor function disorders, the appearance of clumsiness in children with partial epilepsy and primary generalised...
2004: Przegla̧d Lekarski
I G Vlasova, L D Luk'ianova, A T Ugolev
A comparative investigation of morphological, electrophisiological and metabolic indices of the functioning of cerebellar neurons developing in vivo and in conditions of the organotypical culture permitted us to distinguish a period (20--25 days) when properties of the culture of nervous tissue most resemble the characteristics of the brain of adult animals. Cultivated nervous tissue may be used as a model for studies of fine mechanisms of the nervous system functioning in the ontogenesis.
April 1978: Tsitologiia
B Jahan-Parwar, S M Fredman
1. Intracellular stimulation of individual neurons in the two symmetrical A neuron clusters of the cerebral ganglion evoked contractions of both the foot and parapodia. Electrical stimulation of pedal and parapodial nerves caused antidromic action potentials in A neurons. Units recorded in the nerves followed the driven somatic spike 1:1. This suggests that the A neurons are presumptive pedal and parapodial motor neurons.2. Individual A neurons evoked both bilteral and unilateral contractions of the parapodia or split foot...
May 1978: Journal of Neurophysiology
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