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https://www.readbyqxmd.com/read/28646620/atopic-dermatitis-is-inversely-associated-with-hepatitis-b-antigen-positivity-a-population-based-cohort-study
#1
H Y Kim, C W Kim, J Y Choi, D S Yu, J W Kim, K D Han, Y G Park, Y B Lee
BACKGROUND: No clear association between hepatitis B virus (HBV) infection and atopic dermatitis (AD) has been established. Some studies have reported that subjects with HBV had an increased risk of atopy; other studies reported an inverse association between HBV seropositivity and allergic diseases. OBJECTIVE: We evaluated the association between AD and hepatitis B antigen (HBsAg) positivity using Korean National Health and Nutrition Examination Survey data. METHODS: In total, 14,776 participants aged > 19 years were included in the analysis...
June 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28642859/exercise-induced-bronchospasm-and-allergy
#2
REVIEW
Serena Caggiano, Renato Cutrera, Antonio Di Marco, Attilio Turchetta
Sport is an essential part of childhood, with precious and acknowledged positive health effects but the impact of exercise-induced bronchoconstriction (EIB) significantly reduces participation in physical activity. It is important to recognize EIB, differentiating EIB with or without asthma if the transient narrowing of the airways after exercise is associated with asthmatic symptoms or not, in the way to select the most appropriate treatment among the many treatment options available today. Therapy is prescribed based on symptoms severity but diagnosis of EIB is established by changes in lung function provoked by exercise evaluating by direct and indirect tests...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28642748/helicobacter-hygiene-atopy-and-asthma
#3
REVIEW
Muhammad Miftahussurur, Iswan A Nusi, David Y Graham, Yoshio Yamaoka
The hygiene hypothesis links environmental and microbial exposures in early life to the prevalence of atopy, allergy, and asthma. Helicobacter pylori infection is typically acquired in childhood and acquisition of the infection is associated with poor household hygiene. Some population surveys have shown an inverse association between H. pylori infection and atopy, allergy, and asthma leading to the suggestion that H. pylori infection may be protective against disease; others consider it simply a biomarker for poor household hygiene...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28641549/relevance-of-cat-and-dog-sensitization-by-skin-prick-testing-in-childhood-eczema-and-asthma
#4
Kam Lun E Lun Hon, Kathy Yin Ching Tsang, Ting Fan Leung
BACKGROUND: Household animal dander has been implicated as aeroallergen in childhood atopic diseases. Many parents seek healthcare advice if household pet keeping may be detrimental in atopic eczema (AE) and atopies. AIM: We investigated if skin sensitization by cat/dog dander was associated with disease severity and quality of life in children with AE. METHODS: Demographics, skin prick test (SPT) results, disease severity (Nottingham eczema severity score NESS), Children Dermatology Life Quality Index (CDLQI), blood IgE and eosinophil counts of a cohort of AE patients were reviewed...
June 14, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28636737/is-there-an-association-between-migraine-and-allergic-rhinitis
#5
Işıl Adadan Güvenç, Mustafa Acar, Nuray Bayar Muluk, Nagehan Erdogmus Kucukcan, Cemal Cingi
We conducted a prospective study to evaluate nasal signs and symptoms and to perform allergen-specific immunoglobulin E (IgE) testing to investigate the relationship between migraine and allergic rhinitis. Our study group consisted of 40 patients diagnosed with migraine-22 men and 18 women, aged 21 to 38 years (mean: 25.7). We compared their findings with a control group of 40 healthy adults-15 men and 25 women, aged 19 to 36 years (mean: 25.1). Allergen-specific IgE measurements were obtained with six groups of allergens: fungi, grass pollens, tree pollens, wild herbs, house dust mite 1, and house dust mite 2...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28634031/does-atopy-affect-the-course-of-viral-pneumonia
#6
S B Erdem, D Can, S Girit, F Çatal, V Şen, S Pekcan, H Yüksel, A Bingöl, I Bostancı, D Erge, R Ersu
BACKGROUND: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia. METHODS: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild-moderate and severe according to the course of pneumonia...
June 17, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28629670/trends-in-prevalence-and-risk-factors-of-allergic-rhinitis-symptoms-in-primary-schoolchildren-six-years-apart-in-budapest
#7
M Sultész, I Balogh, G Katona, G Mezei, A Hirschberg, G Gálffy
BACKGROUND: Few data are available concerning the time trends and risk factors associated with allergic rhinitis (AR) in schoolchildren in Hungary. METHODS: At an interval of six years, parents of 6-12-year-old children completed identical ISAAC-based and additional questionnaires related to possible risk factors. RESULTS: Response rate was 62.8% with 6335 questionnaires distributed in 2007, and 52.9% with 6441 questionnaires in 2013. The prevalence of current AR symptoms (subjects presenting clinical symptoms of AR in the past 12 months, but had yet to be diagnosed by physician) increased significantly from 14...
June 16, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28627729/the-immune-deficiency-of-chromosome-22q11-2-deletion-syndrome
#8
Megan Morsheimer, Terri F Brown Whitehorn, Jennifer Heimall, Kathleen E Sullivan
The syndrome originally described by Dr. Angelo DiGeorge had immunodeficiency as a central component. When a 22q11.2 deletion was identified as the cause in the majority of patients with DiGeorge syndrome, the clinical features of 22q11.2 deletion syndrome became so expansive that the immunodeficiency became less prominent in our thinking about the syndrome. This review will focus on the immune system and the changes in our understanding over the past 50 years. Initially characterized as a pure defect in T cell development, we now appreciate that many of the clinical features related to the immunodeficiency are well downstream of the limitation imposed by a small thymus...
June 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28625885/dock8-deficiency-insights-into-pathophysiology-clinical-features-and-management
#9
REVIEW
Catherine M Biggs, Sevgi Keles, Talal A Chatila
Dedicator of Cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending beyond recurrent infections to include atopy, autoimmunity and cancer. It is caused by loss of function mutations in DOCK8, encoding a guanine nucleotide exchange factor highly expressed in lymphocytes that regulates the actin cytoskeleton. Additional roles of DOCK8 have also emerged, including regulating MyD88-dependent Toll-like receptor signaling and the activation of the transcription factor STAT3...
June 15, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28619722/corticosteroid-therapy-during-acute-bronchiolitis-in-patients-who-later-develop-asthma
#10
Steven L Shein, Alexandre T Rotta, Richard Speicher, Katherine N Slain, Benjamin Gaston
BACKGROUND AND OBJECTIVE: Meta-analyses show that corticosteroids are not effective in patients with bronchiolitis. However, risk factors for asthma such as eczema or familial atopy prompt some practitioners to prescribe corticosteroids for bronchiolitis. We assessed if corticosteroid prescription is associated with shorter hospitalization for bronchiolitis among patients who later develop asthma. METHODS: The Pediatric Health Information System database was interrogated for patients with bronchiolitis aged <2 years hospitalized between 2006 and 2015...
June 15, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28605217/differences-between-preschoolers-with-asthma-and-allergies-in-urban-and-rural-environments
#11
Daniel A Marfortt, Dario Josviack, Alejandro Lozano, Eduardo Cuestas, Luis Agüero, Jose A Castro-Rodriguez
OBJECTIVE: The influence of living in a rural or urban environment on asthma and allergic diseases in school-children provide conflicting results; moreover none of these studies included exclusively preschoolers. The aim of the present study was to evaluate if recurrent wheezing preschoolers from rural or urban areas differ in asthma, allergic diseases, and atopy. METHODS: A cross-sectional-study in Rafaela, Argentina, on 143 preschoolers with recurrent wheezing from rural and urban settings was performed (2010-2012)...
June 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28603089/specific-allergen-immunotherapy-for-the-treatment-of-allergic-asthma-a-review-of-current-evidence
#12
J Dominguez-Ortega, J Delgado, C Blanco, L Prieto, E Arroabarren, M Cimarra, A Henriquez-Santana, J Iglesias-Souto, J M Vega-Chicote, A I Tabar
Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations...
June 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28599691/vitamin-d-status-lung-function-and-atopy-in-children-with-asthma
#13
Sebnem Ozdogan, Gizem Sari, Ibrahim Hakki Aktan, Belma Aydin, Canan Irmak, Sabanur Cavdar
OBJECTIVE: To determine the associations between serum 25-hydroxy vitamin D3 levels and pulmonary function test outcomes and atopy in children with asthma. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Pediatric pulmonology outpatient clinic and pediatric outpatient clinic, from December 2012 to March 2013. METHODOLOGY: Atotal of 71 asthmatic children and 77 healthy controls aged 7-17 years were recruited...
May 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28599075/increased-risk-of-asthma-in-overweight-children-born-large-for-gestational-age
#14
Leonardo A Pinto, Stefano Guerra, Josep M Anto, Dirkje Postma, Gerard H Koppelman, Johan C de Jongste, Ulrike Gehring, Henriette A Smit, Alet Wijga
BACKGROUND: Being born large for gestational age (LGA) is a marker of increased growth velocity in fetal life and a risk factor for childhood overweight. Both being born LGA and childhood overweight may influence the development of asthma, although the role of overweight in the association between LGA and childhood asthma is unclear. Importantly, recent studies have suggested that the association between overweight and asthma may be related to non-allergic pathways. If this also applies to the association between LGA and asthma, the association between being born LGA and asthma may be different for atopic and non-atopic children...
June 9, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28589116/gene-environment-interactions-what-can-these-tell-us-about-the-relationship-between-asthma-and-allergy
#15
REVIEW
Steve Turner
Asthma is a common condition, which is associated with atopy and allergic conditions including hay fever, eczema, and food allergies. Asthma and atopy are both complex conditions where genetic and environmental factors are implicated in causation. Interactions between genetic and environmental factors, likely via epigenetic mechanisms, are widely thought to be important in determining the risk for developing asthma and atopy. The nature of the relationship between asthma and atopy is unclear and the answer to the question "does atopy cause asthma?" remains unknown...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28588900/associations-between-serum-25-oh-d-concentrations-and-prevalent-asthma-among-children-living-in-communities-with-differing-levels-of-urbanization-a-cross-sectional-study
#16
Suzanne L Pollard, John J Lima, Karina Romero, Carla Tarazona-Meza, Edward Mougey, Katherine Tomaino, Gary Malpartida-Guzmán, Nadia N Hansel, William Checkley
BACKGROUND: Prior evidence suggests that vitamin D deficiency may increase the risk of asthma and atopy and impair pulmonary function in children. METHODS: In this cross-sectional analysis nested in a case-control study, we analyzed serum 25(OH)D concentrations in 413 children with asthma and 471 children without asthma living in two geographically adjacent study communities (Pampas and Villa El Salvador). We measured total and antigen-specific IgE levels, pulmonary function, asthma control, and exhaled nitric oxide...
2017: Asthma research and practice
https://www.readbyqxmd.com/read/28583447/etiology-of-epithelial-barrier-dysfunction-in-patients-with-type-2-inflammatory-diseases
#17
Robert P Schleimer, Sergejs Berdnikovs
Epithelial barriers of the skin, gastrointestinal tract, and airway serve common critical functions, such as maintaining a physical barrier against environmental insults and allergens and providing a tissue interface balancing the communication between the internal and external environments. We now understand that in patients with allergic disease, regardless of tissue location, the homeostatic balance of the epithelial barrier is skewed toward loss of differentiation, reduced junctional integrity, and impaired innate defense...
June 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28583261/cellular-and-noncellular-bloodborne-biomarkers-in-asthma
#18
REVIEW
Hannah Sinz, Harald Renz, Chrysanthi Skevaki
OBJECTIVE: To provide an overview of studied cellular and noncellular blood-derived asthma biomarkers. DATA SOURCES: PubMed literature review. STUDY SELECTIONS: Articles discussing cellular and noncellular bloodborne asthma biomarkers. RESULTS: Discussed asthma biomarkers include peripheral blood cell counts of T cells, fibrocytes, or granulocytes, as well as levels of cytokines, periostin, IgE, and lipid mediators with or without stimulation...
June 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28577804/special-considerations-for-therapy-of-pediatric-atopic-dermatitis
#19
REVIEW
Nanette B Silverberg, Carola Durán-McKinster
Atopic dermatitis is the leading cause of pediatric dermatology visits in developed nations. Recurrent, itchy rashes in typical locations and a family/personal history of atopy helps to identify children with disease. Most cases (85%) are diagnosed by age 5 years. Some comorbidities are age-based and may affect disease course. Topical corticosteroids are the mainstay of therapy; corticosteroidphobia and side effects complicate use. Topical calcineurin inhibitors are alternatives to corticosteroids, especially in sensitive locations...
July 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28574721/a-multi-omics-approach-to-identify-genes-associated-with-childhood-asthma-risk-and-morbidity
#20
Erick Forno, Ting Wang, Qi Yan, John Brehm, Edna Acosta-Perez, Angel Colon-Semidey, Maria Alvarez, Nadia Boutaoui, Michelle M Cloutier, John F Alcorn, Glorisa Canino, Wei Chen, Juan C Celedón
RATIONALE: Childhood asthma is a complex disease. In this study, we aim to identify genes associated with childhood asthma through a multi-omics "vertical" approach that integrates multiple analytical steps using linear and logistic regression models. METHODS: In a case-control study of childhood asthma in Puerto Ricans (n=1127), we use adjusted linear or logistic regression models to evaluate associations between several analytical steps of omics data, including genome-wide (GW) genotype data, GW methylation, GW expression profiling, cytokine levels, asthma-intermediate phenotypes, and asthma status...
June 2, 2017: American Journal of Respiratory Cell and Molecular Biology
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