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JOURNAL ARTICLE
Camille M Powers, Austin J Piontkowski, Brandon Block, Jeremy Orloff, Emma Guttman-Yassky, Nicholas Gulati
No abstract text is available yet for this article.
April 6, 2024: Journal of Allergy and Clinical Immunology in Practice
#2
JOURNAL ARTICLE
Hannah L Cornman, Jaya Manjunath, Sriya V Reddy, Jackson Adams, Ahmad Rajeh, Christeen Samuel, Aaron Bao, Ryan Zhao, Emily Z Ma, Jason Shumsky, Thomas W Pritchard, Brenda Umenita Imo, Alexander L Kollhoff, Kevin K Lee, Weiying Lu, Selina Yossef, Madan M Kwatra, Shawn G Kwatra
Prurigo nodularis (PN) is a chronic inflammatory skin disease that is associated with variability in peripheral blood eosinophil levels and response to T-helper 2 targeted therapies (Th2). Our objective was to determine whether circulating immune profiles with respect to type 2 inflammation differ by race and peripheral blood eosinophil count. Plasma from 56 PN patients and 13 matched healthy controls was assayed for 54 inflammatory biomarkers. We compared biomarker levels between PN and HCs, among PN patients based on absolute eosinophil count, and across racial groups in PN...
April 6, 2024: Scientific Reports
#3
JOURNAL ARTICLE
Eman Shhada, Ali Alakbar Nahle, Hussein Hamdar, Alaa Jlailati, Ali Jawad, Zeinab Nahle, Sawssan Ali
INTRODUCTION AND IMPORTANCE: Right middle lobe syndrome (MLS) is a rare lung disorder primarily affecting children with a history of asthma or atopy. It encompasses a range of pathological and clinical conditions, from recurrent collapses of the middle lobe to bronchiectasis. In this study, the authors present a case series featuring four individuals with MLS associated with asthma, aiming to deepen our understanding of this uncommon condition. CASE PRESENTATION: Four paediatric patients with right MLS exhibited symptoms of persistent cough, dyspnoea, and recurrent asthma exacerbations...
April 2024: Annals of Medicine and Surgery
#4
JOURNAL ARTICLE
David J Jackson, Girolamo Pelaia, Benjamin Emmanuel, Trung N Tran, David Cohen, Vivian H Shih, Anat Shavit, Douglas Arbetter, Rohit Katial, Adrian Paul J Rabe, Esther Garcia Gil, Marisa Pardal, Javier Nuevo, Michael Watt, Silvia Boarino, Sheena Kayaniyil, Cláudia Chaves Loureiro, Alicia Padilla-Galo, Parameswaran Nair
BACKGROUND: Pivotal Phase 3 trials and real-world studies have demonstrated benralizumab's overall efficacy and safety in severe eosinophilic asthma (SEA). Additional large-cohort data are needed to confirm its real-world effectiveness in SEA according to previous biologic use and key baseline characteristics important for treatment selection. METHODS: XALOC-1 is a large, multinational, retrospective, observational, real-world study programme of benralizumab in adults with SEA...
April 4, 2024: European Respiratory Journal
#5
JOURNAL ARTICLE
Samantha Lee, Hind Sbihi, Julia L MacIsaac, Robert Balshaw, Amirthagowri Ambalavanan, Padmaja Subbarao, Piushkumar J Mandhane, Theo J Moraes, Stuart E Turvey, Qingling Duan, Michael Brauer, Jeffrey R Brook, Michael S Kobor, Meaghan J Jones
BACKGROUND: Evidence suggests that prenatal air pollution exposure alters DNA methylation (DNAm), which could go on to affect long-term health. It remains unclear whether DNAm alterations present at birth persist through early life. Identifying persistent DNAm changes would provide greater insight into the molecular mechanisms contributing to the association of prenatal air pollution exposure with atopic diseases. OBJECTIVES: This study investigated DNAm differences associated with prenatal nitrogen dioxide (<mml:math xmlns:mml="https://www...
April 2024: Environmental Health Perspectives
#6
JOURNAL ARTICLE
Cut P Hazlianda, Kristo A Nababan, Yesie Elvira, Nahrisyah
INTRODUCTION: Coronavirus disease 2019 was declared a pandemic by WHO in March 2020. The Indonesian Ministry of Health has recommended many prevention strategies including the use of hand sanitizers (HSs) and the use of personal protective equipment (PPE), especially for healthcare workers. Previous research reported that the increase in the use of HS and PPE is directly proportional to the increase in the incidence of occupational skin diseases. AIMS: To find out the prevalence of work-related contact dermatitis patients related to the use of PPE in healthcare workers at Prof...
2024: Indian Journal of Dermatology
#7
Alice Monzani, Marta Cerutti, Sara Curto, Sara Lovaste, Marta Coppola, Francesca Mercalli, Silvia Saettone, Ivana Rabbone
INTRODUCTION: Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammation of the esophagus, characterized by symptoms related to esophageal dysfunction, resulting from severe eosinophilic infiltration of the esophageal mucosa. It is common in atopic subjects and food antigens have been identified as the most common triggers. However, a seasonal variation in EoE prevalence, correlated with air pollen levels, is reported, suggesting that also aeroallergens may play a role...
2024: Frontiers in Pediatrics
#8
JOURNAL ARTICLE
Michael E Horesh, Marta Martin-Fernandez, Conor Gruber, Sofija Buta, Tom Le Voyer, Eve Puzenat, Harry Lesmana, Yiming Wu, Ashley Richardson, David Stein, Stephanie Hodeib, Mariam Youssef, Jacob A Kurowski, Elizabeth Feuille, Luis A Pedroza, Ramsay L Fuleihan, Alexandria Haseley, Alain Hovnanian, Pierre Quartier, Jérémie Rosain, Georgina Davis, Daniel Mullan, O'Jay Stewart, Roosheel Patel, Angelica E Lee, Rebecca Rubinstein, Leyla Ewald, Nikhil Maheshwari, Virginia Rahming, Ivan K Chinn, James R Lupski, Jordan S Orange, Vanessa Sancho-Shimizu, Jean-Laurent Casanova, Noura S Abul-Husn, Yuval Itan, Joshua D Milner, Jacinta Bustamante, Dusan Bogunovic
Inborn errors of immunity lead to autoimmunity, inflammation, allergy, infection, and/or malignancy. Disease-causing JAK1 gain-of-function (GoF) mutations are considered exceedingly rare and have been identified in only four families. Here, we use forward and reverse genetics to identify 59 individuals harboring one of four heterozygous JAK1 variants. In vitro and ex vivo analysis of these variants revealed hyperactive baseline and cytokine-induced STAT phosphorylation and interferon-stimulated gene (ISG) levels compared with wild-type JAK1...
June 3, 2024: Journal of Experimental Medicine
#9
JOURNAL ARTICLE
Eva Zahradnik, Christoph Nöllenheidt, Ingrid Sander, Alexandra Beine, Martin Lehnert, Frank Hoffmeyer, Monika Raulf
The AllergoVet study longitudinally examines the influence of animal exposure on the development of sensitization and allergic diseases among veterinary medicine students. In this group, contact to animals usually existed long before the study began. Therefore, the aim of this analysis was to investigate lifelong animal species-specific exposure and the prevalence of sensitizations and allergic symptoms already existing before the start of the study. Questionnaire data, including exposure history, were summarized to determine the duration and intensity of animal-related exposure as well as the prevalence of allergic symptoms to animals...
2024: Allergologie Select
#10
JOURNAL ARTICLE
Asma Gaddour, Chayma Sridi, Asma Chouchane, Amene Moussa, Olfa El Maalel, Aicha Brahem, Maher Maoua, Houda Kalboussi, Imene Kacem, Souhail Chatti, Najib Mrizak
INTRODUCTION: Several clinical and epidemiological data point to a possible link between smoking exposure and contact dermatitis (CD). AIMS: To identify the clinical and epidemiological differences of CD in smoking and non-smoking subjects, and to determine the influence of smoking on the allergological profile of CD. METHODS: Retrospective descriptive study who consulted the Department of Occupational Medicine and Occupational Pathology of the Farhat Hached University Hospital of Sousse (Tunisia) during a period of 8 years for exploration of CD and who were tested with the European Standard Battery (ESB)...
March 5, 2024: La Tunisie Médicale
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JOURNAL ARTICLE
Ju-Hyun Lee, Dong-Soon Im
In traditional Korean medicines, Magnolia officinalis is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of Magnolia officinalis . Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood...
March 5, 2024: Life
#12
JOURNAL ARTICLE
Aylin Kont Ozhan, Tugba Arikoglu, Melih Er, Selma Unal, Didem Derici Yıldırım, Funda Erkasar, Şenay Balcı, Lulufer Tamer, Semanur Kuyucu
Background and Objectives : Data on characteristics of asthma in children with sickle cell disease (SCD) is conflicting. Recently, the L-arginine pathway has gained attention in the pathogenesis of asthma and SCD. This study aimed to determine the distinctive clinical and laboratory features and the role of arginine metabolism in asthmatic children with SCD. Materials and Methods : A total of 52 children and adolescents with SCD, including 24 with asthma (SCD-A) and 28 without asthma (SCD-NA), and 40 healthy controls were included...
March 8, 2024: Medicina
#13
JOURNAL ARTICLE
Characteristics of the Gut Microbiota in Regard to Atopic Dermatitis and Food Allergies of Children.
Alexandra I Nekrasova, Irina G Kalashnikova, Maria M Bobrova, Anna V Korobeinikova, Sirozhdin Yu Bakoev, German A Ashniev, Ekaterina S Petryaikina, Alexander S Nekrasov, Angelica V Zagainova, Mariya V Lukashina, Larisa R Tolkacheva, Anastasia S Zhdanova, Vladimir E Mukhin, Vladimir S Yudin, Anton A Keskinov, Valentin V Makarov, Sergey A Kraevoy, Sergey M Yudin
The gut microbiota plays an important role in maintaining human health, as well as in the development of various pathologies, as indicated by a large amount of research. One of the manifestations of an imbalance in the gut microbiome composition is the appearance of various diseases or immune reactions, in particular, atopic dermatitis (AD) and/or food allergies (FA). In this research, using 16S NGS sequencing, it was found that the gut microbiome of children with food allergies and children with atopic dermatitis can be characterized as having higher inflammatory potential...
March 1, 2024: Biomedicines
#14
JOURNAL ARTICLE
Daniela Terra de-Apoena Reche, Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Isabella Siuffi Bergamasco, Thamires Rodrigues de Sousa, Lais Alves do Nascimento, Fernando Roberto Machado Cunha, Marilia Garcia de-Oliveira, Fábio da-Ressureição Sgnotto, Carolina Nunes França, Jefferson Russo Victor
Studies about thymic B cells are scarce in the literature, but it was suggested that they can exert modulatory and regulatory functions on the immune system. Thymic B cells can play some role in regulating the most frequent allergic background worldwide, the atopy induced by the mite Dermatophagoides pteronyssinus (Der p). Here, we aimed to evaluate if the polyclonal IgG repertoire produced by Der p-atopic individuals can influence the homing and cytokine profile of human thymic B derived from non-atopic children aged less than seven days...
March 27, 2024: Scientific Reports
#15
REVIEW
Abarna Thangaraj, Reva Tyagi, Deepti Suri, Sudhir Gupta
Primary immune regulatory disorders (PIRDs) constitute a spectrum of inborn errors of immunity (IEIs) that are primarily characterized by autoimmunity, lymphoproliferation, atopy, and malignancy. In PIRDs, infections are infrequent compared to other IEIs. While susceptibility to infection primarily stems from antibody deficiency, it is sometimes associated with additional innate immune and T or NK cell defects. The use of immunotherapy and chemotherapy further complicates the immune landscape, increasing the risk of diverse infections...
March 17, 2024: Pathogens
#16
JOURNAL ARTICLE
Hyonam Park, Bohee Kim, Yuri Kang, Woonjung Kim
Guava ( Psidium guajava ) is a plant widely distributed in tropical and subtropical regions. Its leaves contain a large amount of physiological molecules such as flavonoid, sesquiterpene, triterpenoid, coumarin, alkaloid, and tannin molecules with antioxidative and anti-inflammatory effects. In this study, the use of concentrated P . guajava leaf extract molecules as a functional natural material was evaluated by confirming the extract's antioxidative, antibacterial, tyrosinase activity inhibition, and collagenase activity inhibition effects and its trans-2-nonenal removal ability...
March 6, 2024: Current Issues in Molecular Biology
#17
JOURNAL ARTICLE
Jashan Mittal, Nikhil Rajvanshi, Kkomal Suvarna, Prawin Kumar, Jagdish Prasad Goyal
UNLABELLED: Vitamin D's role in immune system regulation and its contribution to host defenses against respiratory infections may have implications for bronchiolitis pathophysiology. This cross-sectional study aimed to determine the association between the clinical severity of bronchiolitis and serum vitamin D levels in infants. Infants aged 1 month to 12 months, diagnosed with bronchiolitis, and healthy controls attending routine immunization were enrolled. Baseline characteristics were recorded, including clinical details, bronchiolitis severity, and course during hospital stay...
March 26, 2024: European Journal of Pediatrics
#18
JOURNAL ARTICLE
Makbule Seda Bayrak Durmaz, Done Gulcin Unutmaz, Meryem Demir, Ozlem Goksel, Adile Berna Dursun, Sevim Bavbek
PURPOSE: Taxanes can cause hypersensitivity reactions (HSRs), which pose a significant challenge in the treatment of malignancies. Patients who are eligible for rapid drug desensitization (RDD) can continue treatment; however, some patients experience breakthrough reactions (BTRs). Data about risk factors for BTRs during RDDs in patients with HSRs to taxanes are limited. METHODS: This was a multicenter, retrospective study of patients with immediate-HSRs to taxanes...
March 2024: Allergy, Asthma & Immunology Research
#19
JOURNAL ARTICLE
Jay Patel, Junwen Deng, Anusha Kambala, Kevin K Lee, Hannah L Cornman, Varsha Parthasarathy, Thomas Pritchard, Shihua Chen, Alexei G Hernandez, Sarah Shin, Olusola O Oladipo, Madan M Kwatra, Won Jin Ho, Shawn G Kwatra
Prurigo nodularis (PN) is a chronic, inflammatory skin condition that disproportionately affects African Americans and features intensely pruritic, hyperkeratotic nodules on the extremities and trunk. PN is understudied compared to other inflammatory skin diseases, with the spatial organization of the cutaneous infiltrate in PN yet to be characterized. In this work, we employ spatial imaging mass cytometry to visualize prurigo nodularis lesional skin inflammation and architecture with single cell resolution through an unbiased machine learning approach...
March 22, 2024: Journal of Investigative Dermatology
#20
REVIEW
Nir Erdinest, Dror Ben Ephraim Noyman, Naomi London, Itay Lavy, Nadav Levinger, David Landau, Abraham Solomon, Yair Morad, Shehzad A Naroo
PURPOSE: This meta-analysis aimed to review the safety and efficacy of topical cyclosporine A (CsA) and topical tacrolimus in allergic eye disease. METHODS: A systematic search identified thirteen studies and a total of 445 patients for inclusion, making this the largest meta-analysis published on the subject. The current review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). RESULTS: Thirteen randomized control trials were included in the meta-analysis...
March 24, 2024: International Ophthalmology
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