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https://www.readbyqxmd.com/read/28100228/association-of-stem-cell-factor-gene-expression-with-severity-and-atopic-state-in-patients-with-bronchial-asthma
#1
Safaa I Tayel, Sally M El-Hefnway, Eman M Abd El Gayed, Gehan A Abdelaal
BACKGROUND: Bronchial asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. Stem cell factor (SCF) may contribute to the inflammatory changes occurring in asthma. We aimed to show the expression of SCF gene in patients with asthma as a means of diagnosis and its association with severity and atopic state in these patients. METHODS: This study was carried out on 80 subjects, 50 asthmatic patients and 30 age and gender matched healthy control persons...
January 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28095831/a-follow-up-study-of-airway-symptoms-and-lung-function-among-residents-and-workers-5-5%C3%A2-years-after-an-oil-tank-explosion
#2
Jens-Tore Granslo, Magne Bråtveit, Bjørg Eli Hollund, Stein Håkon Låstad Lygre, Cecilie Svanes, Bente Elisabeth Moen
BACKGROUND: Assess if people who lived or worked in an area polluted after an oil tank explosion had persistent respiratory health impairment as compared to a non-exposed population 5.5 years after the event. METHODS: A follow-up study 5.5 years after the explosion, 330 persons aged 18-67 years, compared lung function, lung function decline and airway symptoms among exposed persons (residents <6 km from the accident site or working in the industrial harbour at the time of the explosion) with a non-exposed group (residence >20 km away)...
January 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28089873/patterns-of-immune-development-in-urban-preschoolers-with-recurrent-wheeze-and-or-atopy
#3
James E Gern, Agustin Calatroni, Katy F Jaffee, Henry Lynn, Amy Dresen, William W Cruikshank, Howard M Lederman, Hugh A Sampson, Wayne Shreffler, Leonard B Bacharier, Peter J Gergen, Diane R Gold, Meyer Kattan, George T O'Connor, Megan T Sandel, Robert A Wood, Gordon R Bloomberg
BACKGROUND: Disadvantaged urban children have high rates of allergic diseases and wheezing, which are diseases associated with Type 2-biased immunity. OBJECTIVE: To determine whether environmental exposures in early life influence cytokine responses which affect the development of recurrent wheezing illnesses and allergic sensitization. METHODS: A birth cohort of 560 urban families was recruited from neighborhoods with high rates of poverty, and 467 (83%) children were followed until 3 years of age...
January 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28089081/asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-literature-review-and-contributions-towards-a-portuguese-consensus
#4
D Araújo, E Padrão, M Morais-Almeida, J Cardoso, F Pavão, R B Leite, A C Caldas, A Marques
INTRODUCTION: Phenotypic overlap between the two main chronic airway pulmonary diseases, asthma and chronic obstructive pulmonary disease (COPD), has been the subject of debate for decades, and recently the nomenclature of asthma-COPD overlap syndrome (ACOS) was adopted for this condition. The definition of this entity in the literature is, however, very heterogeneous, it is therefore important to define how it applies to Portugal. METHODS: A literature review of ACOS was made in a first phase resulting in the drawing up of a document that was later submitted for discussion among a panel of chronic lung diseases experts, resulting in reflexions about diagnosis, treatment and clinical guidance for ACOS patients...
January 6, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28076664/sensitization-predicts-asthma-development-among-wheezing-toddlers-in-secondary-healthcare
#5
Nienke A Boersma, Ruud W H Meijneke, Johannes C Kelder, Cornelis K van der Ent, Walter A F Balemans
INTRODUCTION: Some wheezing toddlers develop asthma later in childhood. Sensitization is known to predict asthma in birth cohorts. However, its predictive value in secondary healthcare is uncertain. AIM: This study examines the predictive value of sensitization to inhalant allergens among wheezing toddlers in secondary healthcare for the development of asthma at school age (≥6 years). METHODS: Preschool children (1-3 years) who presented with wheezing in secondary healthcare were screened on asthma at school age with the International Study of Asthma and Allergies in Childhood questionnaire...
January 11, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28062882/anaphylaxis-in-children-experience-of-485-episodes-in-1-272-482-patient-attendances-at-a-tertiary-paediatric-emergency-department-from-2007-to-2014
#6
Sashikumar Ganapathy, Zaw Lwin, Daniel Ha Ting, Lynette Sh Goh, Shu Ling Chong
Introduction: Anaphylaxis is a predominantly childhood disease. Most of the literature on anaphylaxis has emerged from Western countries. This study aimed to describe the incidence, triggers and clinical presentation of anaphylaxis among children in Singapore, look for predictors for anaphylaxis with severe outcomes, and study the incidence of biphasic reactions. Materials and Methods: We retrospectively reviewed records of children presenting with anaphylaxis to our paediatric emergency department from 1 January 2007 to 31 December 2014...
December 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28056905/determinants-of-chronic-otitis-media-with-effusion-in-preschool-children-a-case-control-study
#7
Rebecca E Walker, Jim Bartley, David Flint, John M D Thompson, Edwin A Mitchell
BACKGROUND: Chronic otitis media with effusion (COME) is a prevalent upper airway infection resulting in hearing loss. The aim of this research was to determine risk factors for COME in preschool children. METHODS: A case-control design was conducted in Auckland, New Zealand from May 2011 until November 2013. The cases were children aged 3 and 4 years referred for tympanostomy tube placement due to a diagnosis of COME (n = 178). The controls were a random sample of healthy children aged 3 and 4 years from primary care practices (n = 209)...
January 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28050486/patch-test-as-a-diagnostic-tool-in-hand-eczema
#8
Natarajan Vigneshkarthik, Satyaki Ganguly, Sheela Kuruvila
INTRODUCTION: Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Accordingly, patterns of allergic contact dermatitis differ in different parts of the world and different regions of the same country. AIM: To study the causes of allergic contact dermatitis in adult patients with hand eczema with the help of patch testing...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049210/hypersensitivity-reactions-to-nonsteroidal-anti-inflammatory-drugs-among-adults-clinical-features-and-risk-factors-for-diagnosis-confirmation
#9
Eva Rebelo Gomes, Luísa Geraldes, Ângela Gaspar, Daniela Malheiro, Susana Cadinha, Carmo Abreu, Marta Chambel, Eugénia Almeida, Emília Faria
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical history, and provocation tests are considered the gold standard for diagnosis. Skin tests have some value to study reactions to pyrazolones. Laboratory investigations are mostly used for research purposes. Different phenotypes have been described. OBJECTIVE AND METHODS: Our aim was to describe the most common clinical manifestations of NSAID HS in a large population of adult patients, the drugs involved, the association with previously described risk factors, and the outcome of diagnostic procedures...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28049194/early-intervention-improves-clinical-responses-to-house-dust-mite-immunotherapy-in-allergic-rhinitis-patients
#10
Shanshan Qi, Hao Chen, Nan Huang, Wenjing Li, Guanghui Liu, Yin Wang, Lintao Hu, Xiaolong Wang, Wei Zhang, Rongfei Zhu
BACKGROUND: Allergen immunotherapy (AIT) is the unique causal treatment for respiratory allergy. As AIT is expensive and of long duration, the availability of a marker predicting AIT responders is of crucial relevance. OBJECTIVE: To investigate clinical parameters correlated with effective AIT in allergic rhinitis (AR) patients. METHODS: This is a prospective, nonrandomized open study in which a total of 284 AR patients who had received house dust mite (HDM) subcutaneous AIT were enrolled from January 2011 to December 2015, and then followed up for 3 consecutive years...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28043213/clinical-relevance-of-ige-mediated-sensitization-against-the-mould-alternaria-alternata-in-children-with-asthma
#11
Sylvia Lehmann, Anja Sprünken, Norbert Wagner, Klaus Tenbrock, Hagen Ott
BACKGROUND: Asthma in childhood has a prevalence of 5-10% in Germany and severe asthma accounts for about 5% in this patient group. Positive predictive values for severe asthma are atopy, a positive family history and sensitizations against inhalative allergens. Alternaria is an important inhalative allergen and sensitization is suspected to correlate with severe and lethal asthma. We investigated the prevalence and impact of Alternaria sensitization in paediatric asthma. METHODS: We reviewed paediatric patients with a diagnosis of low-grade, moderate and severe asthma...
January 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28029408/gut-microbiota-and-allergy-asthma-from-pathogenesis-to-new-therapeutic-strategies
#12
REVIEW
Y B Kang, Y Cai, H Zhang
Asthma and atopy, classically associated with hyper-activation of the T helper 2 (Th2) arm of adaptive immunity, are among the most common chronic illnesses worldwide. Emerging evidence relates atopy and asthma to the composition and function of gut microbiota composition. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. Although still a relatively nascent field of research, evidence to date suggests that the gut microbiome may represent fertile targets for prevention or management of allergic asthma and other diseases in which adaptive immune dysfunction is a prominent feature...
October 28, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28027401/breast-milk-poly-unsaturated-fatty-acids-associations-with-adolescent-allergic-disease-and-lung-function
#13
Nilakshi T Waidyatillake, Rachel Stoney, Francis Thien, Caroline J Lodge, Julie A Simpson, Katrina J Allen, Michael J Abramson, Bircan Erbas, Cecile Svanes, Shyamali C Dharmage, Adrian J Lowe
BACKGROUND: It has been hypothesised that n-3 PUFA in breast-milk may assist immune and lung development. There are very limited data on possible long-term effects on allergic disease and lung function. The aim was to investigate associations of n-3 and n-6 PUFA levels in colostrum and breast milk with allergic disease and lung function at ages 12 and 18 years. METHOD: PUFAs were measured in 194 colostrum samples and in 118 three month expressed breast milk samples from mothers of children enrolled in the Melbourne Atopy Cohort (MACS) Study, a high risk birth cohort study...
December 27, 2016: Allergy
https://www.readbyqxmd.com/read/28017441/extensive-swelling-of-the-limb-and-systemic-symptoms-after-a-fourth-dose-of-acellular-pertussis-containing-vaccines-in-england-in-children-aged-3-6years
#14
Jo Southern, Pauline A Waight, Nick Andrews, Elizabeth Miller
Extensive limb swelling (ESL) after a booster dose of acellular pertussis (aP) containing vaccine can cause concern and has the potential to be confused with cellulitis. In the United Kingdom aP-containing vaccine was introduced for primary immunisation at 2, 3 and 4months of age in 2004, with the first cohorts eligible to receive a fourth dose in 2007 at school entry. We assessed the frequency of ESL (here defined as swelling >100mms diameter) in 973 children receiving a fourth dose of one of four aP vaccines given combined with inactivated polio, tetanus and either low dose diphtheria (TdaP/IPV) or high dose diphtheria (DTaP/IPV) vaccine; 2 of the 3 DTaP/IPV vaccines also contained Haemophilus influenza b conjugate vaccine (Hib)...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28011791/maternal-smoking-and-newborn-cytokine-and-immunoglobulin-levels
#15
Nikhita Chahal, Alexander C McLain, Akhgar Ghassabian, Kara A Michels, Erin M Bell, David A Lawrence, Edwina H Yeung
INTRODUCTION: Prenatal smoking exposure may lead to permanent changes in neonatal inflammation and immune response that have lifelong implications, including increased risks for atopy and respiratory disorders. METHODS: The effect of maternal smoking on neonatal biomarkers of inflammation and immune response was assessed among 3459 singletons and twins in the Upstate KIDS Study. The following inflammatory biomarkers were measured using newborn dried blood spots (DBSs): interleukin (IL)-1α, IL-1 receptor antagonist, IL-6, IL-8, C-reactive protein, and tumor necrosis factor alpha...
December 23, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28007089/epidemiology-of-anaphylaxis-at-a-tertiary-care-center-a-report-of-730-cases
#16
Alexei Gonzalez-Estrada, Stacy K Silvers, Asaf Klein, Katrina Zell, Xiao-Feng Wang, David M Lang
BACKGROUND: Recent data reveal that the rate of anaphylaxis is increasing and suggest that idiopathic anaphylaxis may account for most of these cases. OBJECTIVE: To determine the pattern of anaphylaxis at a tertiary care referral center. METHODS: A retrospective electronic medical record review spanning 12 years (2002-2013) identified patients with anaphylaxis. RESULTS: Of the 4,777 records reviewed, 730 patients met our anaphylaxis definition...
January 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28000962/hypoxia-causes-il-8-secretion-charcot-leyden-crystal-formation-and-suppression-of-corticosteroid-induced-apoptosis-in-human-eosinophils
#17
Linsey M Porter, Andrew S Cowburn, Neda Farahi, John Deighton, Stuart N Farrow, Christine A Fiddler, Jatinder K Juss, Alison M Condliffe, Edwin R Chilvers
BACKGROUND: Inflamed environments are typically hypercellular, rich in pro-inflammatory cytokines, and profoundly hypoxic. While the effects of hypoxia on neutrophil longevity and function have been widely studied, little is known about the consequences of this stimulus on eosinophils. OBJECTIVE: We sought to investigate the effects of hypoxia on several key aspects of eosinophil biology; namely secretion, survival, and their sensitivity to glucocorticosteroids (GCS), agents which normally induce eosinophil apoptosis...
December 21, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27990118/cysteinyl-leukotrienes-pathway-genes-atopic-asthma-and-drug-response-from-population-isolates-to-large-genome-wide-association-studies
#18
REVIEW
Miles D Thompson, Valerie Capra, Mark T Clunes, G E Rovati, Jana Stankova, Mary C Maj, David L Duffy
Genetic variants associated with asthma pathogenesis and altered response to drug therapy are discussed. Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene synthesis and intracellular signaling through activation of seven transmembrane domain receptors, such as the cysteinyl leukotriene 1 (CYSLTR1) and 2 (CYSLTR2) receptors. The leukotrienes are polyunsaturated lipoxygenated eicosatetraenoic acids that exhibit a wide range of pharmacological and physiological actions...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27988066/laryngeal-mucosal-reaction-during-bronchial-histamine-challenge-test-visualized-by-videolaryngostroboscopy
#19
Maaria Ansaranta, Ahmed Geneid, Paula Kauppi, Leo Pekka Malmberg, Erkki Vilkman
OBJECTIVES/HYPOTHESIS: To examine the changes in the larynx, as well as self-reported voice and throat symptoms, among patients undergoing a histamine challenge test. Thus, to understand the possible clinical effects of histamine on the larynx. STUDY DESIGN: Controlled, open prospective study. METHODS: Thirty adult patients with prolonged cough and suspicion of bronchial asthma underwent a histamine challenge test. Videolaryngostroboscopy was performed immediately before and after the challenge...
December 14, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27986410/simplification-of-intradermal-skin-testing-in-hymenoptera-venom-allergic-children
#20
Ewa Cichocka-Jarosz, Marcin Stobiecki, Piotr Brzyski, Iwona Rogatko, Marita Nittner-Marszalska, Krystyna Sztefko, Ewa Czarnobilska, Grzegorz Lis, Anna Nowak-Węgrzyn
BACKGROUND: The direct comparison between children and adults with Hymenoptera venom anaphylaxis (HVA) has never been extensively reported. Severe HVA with IgE-documented mechanism is the recommendation for venom immunotherapy, regardless of age. OBJECTIVE: To determine the differences in the basic diagnostic profile between children and adults with severe HVA and its practical implications. METHODS: We reviewed the medical records of 91 children and 121 adults...
December 13, 2016: Annals of Allergy, Asthma & Immunology
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