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Trigger Finger

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https://www.readbyqxmd.com/read/28546512/wnt5a-promotes-frizzled-4-signalosome-assembly-by-stabilizing-cysteine-rich-domain-dimerization
#1
Zachary J DeBruine, Jiyuan Ke, Kaleeckal G Harikumar, Xin Gu, Peter Borowsky, Bart O Williams, Wenqing Xu, Laurence J Miller, H Eric Xu, Karsten Melcher
Wnt/β-catenin signaling is activated when extracellular Wnt ligands bind Frizzled (FZD) receptors at the cell membrane. Wnts bind FZD cysteine-rich domains (CRDs) with high affinity through a palmitoylated N-terminal "thumb" and a disulfide-stabilized C-terminal "index finger," yet how these binding events trigger receptor activation and intracellular signaling remains unclear. Here we report the crystal structure of the Frizzled-4 (FZD4) CRD in complex with palmitoleic acid, which reveals a CRD tetramer consisting of two cross-braced CRD dimers...
May 25, 2017: Genes & Development
https://www.readbyqxmd.com/read/28539513/evidence-for-parallel-evolution-of-a-gene-involved-in-the-regulation-of-spermatogenesis
#2
Xin Rui Wang, Li Bin Ling, Hsiao Han Huang, Jau Jyun Lin, Sebastian D Fugmann, Shu Yuan Yang
PHD finger protein 7 (Phf7) is a male germline specific gene in Drosophila melanogaster that can trigger the male germline sexual fate and regulate spermatogenesis, and its human homologue can rescue fecundity defects in male flies lacking this gene. These findings prompted us to investigate conservation of reproductive strategies through studying the evolutionary origin of this gene. We find that Phf7 is present only in select species including mammals and some insects, whereas the closely related G2/M-phase specific E3 ubiquitin protein ligase (G2e3) is in the genome of most metazoans...
May 31, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28538530/clinical-assessment-and-diagnostics-of-patients-with-hand-disorders-a-case-study-approach
#3
Mabel Qi He Leow, Rebecca Qian Ru Lim, Shian Chao Tay
Clinical assessment of the hand is important for diagnosing underlying hand disorders. Using a case study approach, the clinical assessment for three disorders of the hands is presented: trigger finger (stenosing tenosynovitis), carpal tunnel syndrome, and ulnar-sided wrist injury (styloid impingement). We assess the annular one pulley and finger range of motion for patients with trigger finger. To diagnose for carpal tunnel syndrome, assessment for Tinel's sign, Phalen's sign, abductor pollicis brevis muscle bulk, two-point discrimination, and obtaining a nerve conduction study are performed...
May 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28537256/design-of-synthetic-epigenetic-circuits-featuring-memory-effects-and-reversible-switching-based-on-dna-methylation
#4
Johannes A H Maier, Raphael Möhrle, Albert Jeltsch
Epigenetic systems store information in DNA methylation patterns in a durable but reversible manner, but have not been regularly used in synthetic biology. Here, we designed synthetic epigenetic memory systems using DNA methylation sensitive engineered zinc finger proteins to repress a memory operon comprising the CcrM methyltransferase and a reporter. Triggering by heat, nutrients, ultraviolet irradiation or DNA damaging compounds induces CcrM expression and DNA methylation. In the induced on-state, methylation in the operator of the memory operon prevents zinc finger protein binding leading to positive feedback and permanent activation...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28530766/right-ring-finger-volar-mass-in-a-14-year-old-boy
#5
Mary P Fox, Jack E McKay, Randall D Craver, Nicholas D Pappas
A trigger digit is relatively uncommon in adolescents and often has a different etiology in that age group vs adults. In the pediatric population, trigger digits frequently arise from a variety of underlying anatomic situations, including thickening of the flexor digitorum superficialis or flexor digitorum profundus tendons, an abnormal relationship between the flexor digitorum superficialis and flexor digitorum profundus tendons, a proximal flexor digitorum superficialis decussation, or constriction of the pulleys...
May 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28506168/trigger-finger-an-atraumatic-medical-phenomenon
#6
Angelo V Vasiliadis, Iraklis Itsiopoulos
Trigger finger is a mechanical problem with many etiological factors as possible causes, such as diabetes mellitus, carpal tunnel syndrome and repetitive finger movements. Although it can afflict anyone, it is much commoner in middle-aged women than men and the most commonly involved digit is reported to be the thumb. The diagnosis is mainly based on clinical symptoms during examination and first-line treatment is conservative with splinting and corticosteroid injections. Surgical open release is the "gold standard" of trigger finger treatment because it allows more careful inspection of the surgical area and is highly effective with low complication rates...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28506159/progression-from-injection-to-surgery-for-trigger-finger-a-statistical-analysis
#7
Hideyuki Ota, Katsuyuki Iwatsuki, Shigeru Kurimoto, Koji Iida, Hitoshi Hirata
BACKGROUND: The purpose of this study was to identify predictive factors of poor response to intra-flexoral sheath corticosteroid injection, as well as to identify factors associated with patients' decisions to undergo surgical treatment. METHODS: Data from 112 patients who received steroid injection treatment for trigger finger were reviewed retrospectively. Logistic regression was used to assess the prognostic value of factors assumed to affect prognosis (age, sex, underlying disease, history of illness, presence of carpal tunnel syndrome, multiple digit involvement, and pre- and post-operative disability scores)...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28455959/ovol2-antagonizes-tgf-%C3%AE-signaling-to-regulate-epithelial-to-mesenchymal-transition-during-mammary-tumor-metastasis
#8
Rong-Si Wu, Jing-Jing Hong, Jia-Fa Wu, Shen Yan, Di Wu, Na Liu, Qing-Feng Liu, Qiu-Wan Wu, Yuan-Yuan Xie, Yun-Jia Liu, Zhong-Zheng Zheng, Err-Cheng Chan, Zhi-Ming Zhang, Bo-An Li
Great progress has been achieved in the study of the role of TGF-β signaling in triggering epithelial-mesenchymal transition (EMT) in a variety of cancers; however, the regulation of TGF-β signaling during EMT in mammary tumor metastasis has not been completely defined. In the present study, we demonstrated that OVOL2, a zinc finger transcription factor, inhibits TGF-β signaling-induced EMT in mouse and human mammary tumor cells, as well as in mouse tumor models. Data from the Oncomine databases indicated a strong negative relationship between OVOL2 expression and breast cancer progression...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454779/congenital-extensor-tendon-dislocation-causing-pseudotriggering-of-the-little-finger
#9
Meriç Çırpar, Bülent Dağlar, Birhan Oktaş
The main complaints in extensor tendon dislocations are pain, swelling, sense of discomfort, snapping and difficulty in writing and forceful flexion. However, congenital extensor tendon subluxations may present with triggering of the fingers due to tendon dislocations. Unnecessary A1 pulley release may be performed for pseudotriggerring with unsuccessful results. Here, we report an unusual case of congenital extensor tendon subluxation of multiple digits with triggering of the left little finger and aim to attract notice to pseudotriggering of the digits due to tendon dislocations...
April 25, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28443675/the-effect-of-trigger-finger-injection-site-on-injection-related-pain
#10
Yoseph A Rosenbaum, Nikki Benvenuti, Jingzhen Yang, Michael E Ruff, Hisham M Awan, Julie Balch Samora
BACKGROUND: Stenosing tenosynovitis, or trigger digit, is a common condition for which patients often seek relief. Corticosteroid injections have been shown to provide relief in many cases, and several different approaches for delivering the injection have been described in the literature. We compared patients' perception of pain following each of 3 accepted injection methods, namely, palmar proximal, palmar distal, and webspace approaches. METHODS: We prospectively followed 38 patients with 39 symptomatic digits in this trial, with varying severities of trigger finger as graded by the Patel and Moradia classification...
April 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28435575/outpatient-percutaneous-release-of-trigger-finger-a-cost-effective-and-safe-procedure
#11
Z Marij, Q Aurangzeb, H R Rizwan, R Haroon, M H Pervaiz
INTRODUCTION: Trigger finger is a common cause of pain and disability of the hand. Percutaneous release results in earlier functional recovery and patient satisfaction. This is a rapid and cost-effective method which saves a surgical procedure and results in better functional outcome. MATERIALS AND METHODS: This is a prospective observational study conducted on fifty-two fingers and thumbs in 52 patients treated from 1st July 2014 till 31st December 2014, in the Orthopaedic Section, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan...
March 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28385637/trigger-factor-induced-nascent-chain-dynamics-changes-suggest-two-different-chaperone-nascent-chain-interactions-during-translation
#12
Jiří Koubek, Yi-Che Chang, Sunny Yao-Chen Yang, Joseph Jen-Tse Huang
Protein biogenesis is poorly understood due to the ribosome which perturbs measurement attempted on the ribosome-bound nascent chain (RNC). Investigating nascent chain dynamics may provide invaluable insight into the co-translational processes such as structure formation or interaction with a chaperone, e.g. the bacterial Trigger Factor (TF). In this study, we aim to establish a platform for studying nascent chain dynamics by exploring the local environment near the fluorescent dye on site-specifically labeled RNCs with time-resolved fluorescence anisotropy...
April 3, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28372638/long-term-effectiveness-of-repeat-corticosteroid-injections-for-trigger-finger
#13
Agnes Z Dardas, James VandenBerg, Tony Shen, Richard H Gelberman, Ryan P Calfee
PURPOSE: To quantify the long-term success of repeat injections for trigger fingers and to identify predictors of treatment outcomes. METHODS: This retrospective case series analyzed 292 repeat corticosteroid injections for trigger fingers administered by hand surgeons at a single tertiary center between January 2010 and January 2013. One hundred eighty-seven patients (64%) were female, 139 patients (48%) had multiple trigger fingers, and 63 patients (22%) were diabetic...
April 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28369468/patterns-of-stress-response-and-tolerance-based-on-transcriptome-profiling-of-rice-crown-tissue-under-zinc-deficiency
#14
Amrit K Nanda, Vincent Pujol, Matthias Wissuwa
Zinc (Zn) deficiency is the most prevalent micronutrient disorder in rice and leads to delayed development and decreased yield. Several studies have investigated how rice plants respond to Zn deficiency and examined the differences between Zn-efficient (ZE) and Zn-inefficient (ZI) genotypes. ZE genotypes reallocate more Zn to roots and are better at maintaining crown root development than ZI genotypes in response to Zn deficiency. However, little is known about the molecular mechanisms controlling these differences...
March 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28365489/subliminal-modulation-of-voluntary-action-experience-a-neuropsychological-investigation
#15
N Khalighinejad, A Kunnumpurath, C Bertini, E Ladavas, P Haggard
Human voluntary actions are often associated with a distinctive subjective experience termed 'sense of agency'. This experience could be a reconstructive inference triggered by monitoring one's actions and their outcomes, or a read-out of brain processes related to action preparation, or some hybrid of these. Participants pressed a key with the right index finger at a time of their own choice, while viewing a rotating clock. Occasionally they received a mild shock on the same finger. They were instructed to press the key as quickly as possible if they felt a shock...
March 10, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28364428/enhanced-memory-consolidation-via-automatic-sound-stimulation-during-non-rem-sleep
#16
Miika M Leminen, Jussi Virkkala, Emma Saure, Teemu Paajanen, Phyllis C Zee, Giovanni Santostasi, Christer Hublin, Kiti Müller, Tarja Porkka-Heiskanen, Minna Huotilainen, Tiina Paunio
Introduction: Slow-wave sleep (SWS) slow waves and sleep spindle activity have been shown to be crucial for memory consolidation. Recently, memory consolidation has been causally facilitated in human participants via auditory stimuli phase-locked to SWS slow waves. Aims: Here, we aimed to develop a new acoustic stimulus protocol to facilitate learning and to validate it using different memory tasks. Most importantly, the stimulation setup was automated to be applicable for ambulatory home use...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28341069/open-surgery-versus-ultrasound-guided-corticosteroid-injection-for-trigger-finger-a-randomized-controlled-trial-with-1-year-follow-up
#17
Rehne L Hansen, Morten Søndergaard, Jeppe Lange
PURPOSE: Trigger finger is a common condition with a lifetime prevalence of 2%. Corticosteroid injection is a treatment often considered as a first-line intervention with reported cure rates between 60% and 90% in observational cohorts. Nevertheless, open surgery remains the most effective treatment with reported cure rates near 100%. Head-to-head trials on these treatments are limited. We investigated the efficacy of open surgery compared with ultrasound-guided corticosteroid injections...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28273063/krab-zinc-finger-proteins-contribute-to-the-evolution-of-gene-regulatory-networks
#18
Michaël Imbeault, Pierre-Yves Helleboid, Didier Trono
The human genome encodes some 350 Krüppel-associated box (KRAB) domain-containing zinc-finger proteins (KZFPs), the products of a rapidly evolving gene family that has been traced back to early tetrapods. The function of most KZFPs is unknown, but a few have been demonstrated to repress transposable elements in embryonic stem (ES) cells by recruiting the transcriptional regulator TRIM28 and associated mediators of histone H3 Lys9 trimethylation (H3K9me3)-dependent heterochromatin formation and DNA methylation...
March 23, 2017: Nature
https://www.readbyqxmd.com/read/28268673/development-of-a-closed-loop-system-for-tremor-suppression-in-patients-with-parkinson-s-disease
#19
F L Xu, M Z Hao, S Q Xu, Z X Hu, Q Xiao, N Lan
More than 70% of patients suffering Parkinson's disease (PD) exhibit resting tremor in their extremities, hampering their ability to perform daily activities. Based on our earlier studies on corticospinal transmission of tremor signals [10,11], we hypothesize that cutaneous afferents evoked by surface stimulation can produce an inhibitory effect on propriospinal neurons (PN), which in turn will suppress tremor signals passing through the PN. This paper presents the development of a closed-loop system for tremor suppression by transcutaneous electrical nerve stimulation (TENS) of sensory fibers beneath the skin...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268404/a-temperature-controlled-glove-with-non-invasive-arterial-pulse-sensing-for-active-neuro-vascular-assessment
#20
Andrew M Carek, Omer T Inan
A non-invasive, active neuro-vascular assessment system was developed using a modified temperature-controlled glove and feedback techniques. The glove incorporates local heating and cooling of the hand using multi-point skin temperature measurements as feedback, and thereby induces local and central mechanisms involved in thermoregulation. Electrocardiogram (ECG), photoplethysmogram (PPG) and non-invasive finger-cuff based blood pressure (BP) measurements were used to monitor electrophysiology and hemodynamic changes in response to temperature modulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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