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Trigger Finger

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https://www.readbyqxmd.com/read/29778347/management-of-diabetic-trigger-finger
#1
REVIEW
Alexander S Kuczmarski, Andrew P Harris, Joseph A Gil, Arnold-Peter C Weiss
Diabetics have a much greater prevalence of trigger finger than nondiabetics and are more likely to have severe symptoms. Diabetic trigger finger may be more accurately described on a spectrum of diabetic hand pathology alongside carpal tunnel syndrome and cheiroarthropathy. Recent publications have called into question the current treatment algorithm for diabetic trigger finger. Although some evidence supports the use of corticosteroid injections, a recent cost analysis reported that immediate surgical release of the A1 pulley in the clinic is the most cost-effective management of diabetic trigger finger...
May 16, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29764283/minimally-invasive-thread-trigger-digit-release-a-preliminary-report-on-34-digits-of-the-adult-hands
#2
Danqing Guo, Logan McCool, Alexander Senk, Brionn Tonkin, Joseph Guo, Rachel M Lytie, Danzhu Guo
The trigger finger release was performed in 34 digits (11 thumbs and 23 fingers) of 24 patients through the thread transecting technique with the tip-to-tip approach, in which a 22-gauge needle inserts into a 18-gauge needle when both needles are inside the hand, guiding the 22-gauge needle to exit the hand at the same access point of 18-gauge needle. We prospectively evaluated the effectiveness and functional recovery of these patients. In all 34 digits, triggering and locking were resolved, and complete extension and flexion occurred immediately following the release...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29760876/rinck-mediated-monoubiquitination-of-cgas-promotes-antiviral-innate-immune-responses
#3
Zhao-Shan Liu, Zi-Yu Zhang, Hong Cai, Ming Zhao, Jie Mao, Jiang Dai, Tian Xia, Xue-Min Zhang, Tao Li
Background: As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cGAS with DNA leads to the synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which binds and activates the downstream adaptor protein STING to promote type I interferon production. Although cGAS has been shown to play a pivotal role in innate immunity, the exact regulation of cGAS activation is not fully understood...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29759125/common-soft-tissue-musculoskeletal-pain-disorders
#4
REVIEW
Matthew J Hubbard, Bernard A Hildebrand, Monica M Battafarano, Daniel F Battafarano
Soft tissue musculoskeletal pain disorders are common in the primary care setting. Early recognition and diagnosis of these syndromes minimizes patient pain and disability. This article gives a brief overview of the most common soft tissue musculoskeletal pain syndromes. The authors used a regional approach to organize the material, as providers will encounter these syndromes with complaints of pain referring to an anatomic location. The covered disorders include myofascial pain syndrome, rotator cuff tendinopathy, bicipital tendinopathy, subacromial bursitis, olecranon bursitis, epicondylitis, De Quervain disease, trigger finger, trochanteric bursitis, knee bursitis, pes anserine bursitis, Baker cyst, plantar fasciitis, and Achilles tendinopathy...
June 2018: Primary Care
https://www.readbyqxmd.com/read/29749533/egf-upregulates-rfpl3-and-htert-via-the-mek-signaling-pathway-in-non%C3%A2-small-cell-lung-cancer-cells
#5
Chuan Lin, Yu Qin, Hua Zhang, Ming-Yang Gao, Yan-Fu Wang
Activation of the epidermal growth factor receptor (EGFR) during tumor development can trigger the MEK signaling pathway. In the present study, we investigated the MEK signaling pathway in non‑small cell lung cancer (NSCLC) cells with respect to the effect of epidermal growth factor (EGF) on expression of Ret finger protein like 3 (RFPL3) and human telomerase reverse transcriptase (hTERT), and the effect of RFPL3 overexpression on other MEK signaling proteins. In vitro, A549 and H1299 cells were treated with different concentrations of EGF for 24 h or 48 h...
May 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29739454/l-menthol-attenuates-the-magnitude-of-cold-induced-vasodilation-on-the-extremities-of-young-females
#6
Siyeon Kim, Joo-Young Lee
BACKGROUND: Menthol chemically triggers cold-sensitive receptors in the skin without conductive skin cooling. We investigated the effects of menthol-induced activation of cutaneous cold receptors on the cold-induced vasodilation (CIVD) of the finger. We hypothesized that the menthol application would attenuate typical CIVD responses. METHODS: 1.5% L-menthol was fully applied over the left hand and forearm, and then, the middle finger of the left hand was immersed into 4 °C water for 30 min...
May 9, 2018: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/29734896/different-dosages-of-triamcinolone-acetonide-injection-for-the-treatment-of-trigger-finger-and-thumb-a-randomized-controlled-trial
#7
Arkaphat Kosiyatrakul, Wittawat Loketkrawee, Suriya Luenam
BACKGROUND: This study was designed to compare the efficacy and complications between 3 different dosages of triamcinolone acetonide for the treatment of trigger finger. METHODS: Ninety-three patients with a total of 120 trigger digits were included in the study. The involved digits were randomized to 3 groups. Each group received treatment consisting of injection with 5, 10 or 20 mg triamcinolone acetonide. The clinical response to the steroid was evaluated during the first six weeks after injection...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29683552/cac3h14-encoding-a-tandem-ccch-zinc-finger-protein-is-directly-targeted-by-cawrky40-and-positively-regulates-the-response-of-pepper-to-inoculation-by-ralstonia-solanacearum
#8
Ailian Qiu, Yufen Lei, Sheng Yang, Ji Wu, Jiazhi Li, Bingjin Bao, Yiting Cai, Song Wang, Jinhui Lin, Yuzhu Wang, Lei Shen, Jinsen Cai, Deyi Guan, Shuilin He
Tandem CCCH Zinc Finger (TZnF) proteins have been implicated in plant defense, but their role in pepper (Capsicum annuum) is unclear. In the present study, the role of CaC3H14, a pepper TZnF protein, in the immune response of pepper plants to Ralstonia solanacearum infection was characterized. When fused to the green fluorescent protein, CaC3H14 was localized exclusively to nuclei in leaf cells of Nicotiana benthamiana plants transiently overexpressing CaC3H14. Transcript abundance of CaC3H14 was upregulated by inoculation with R...
April 23, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29678758/identification-of-memory-reactivation-during-sleep-by-eeg-classification
#9
Suliman Belal, James Cousins, Wael El-Deredy, Laura Parkes, Jules Schneider, Hikaru Tsujimura, Alexia Zoumpoulaki, Marta Perapoch, Lorena Santamaria Covariabus, Penelope Lewis
Memory reactivation during sleep is critical for consolidation, but also extremely difficult to measure as it is subtle, distributed and temporally unpredictable. This article reports a novel method for detecting such reactivation in standard sleep recordings. During learning, participants produced a complex sequence of finger presses, with each finger cued by a distinct audio-visual stimulus. Auditory cues were then re-played during subsequent sleep to trigger neural reactivation through a method known as targeted memory reactivation (TMR)...
April 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29663645/genetically-engineered-supercharged-polypeptide-fluids-fast-and-persistent-self-ordering-induced-by-a-touch
#10
Lei Zhang, Chao Ma, Jing Sun, Baiqi Shao, Giuseppe Portale, Dong Chen, Kai Liu, Andreas Herrmann
Mechanically induced disorder-order transitions have been studied in fluid surfactant solutions or polymer thermotropic liquid crystals. However, the isothermally induced ordered phases do not persist after cessation of shear, which limits their technological applicability to a great extent. Moreover, no such stimuli-responsive materials involving biomacromolecules have been reported although biopolymer liquids are gaining a lot of attention. Here we introduce a new type of biological fluid system in which anionic polypeptides are complexed with cationic surfactants...
April 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29655486/comprehensive-simulation-on-morphological-and-mechanical-properties-of-trigger-finger-a-cadaveric-model
#11
Yu-Shiuan Cheng, Hsiao-Feng Chieh, Chien-Ju Lin, Li-Chieh Kuo, Kai-Nan An, Fong-Chin Su
Trigger finger has long been a common disorder in hand orthopedics. To clarify the unknown causative factors regarding the disease, numerous experiments were done on human cadavers, including tendon forces, tendon moment arm, mechanical properties of the pulley, gliding resistance, etc. However, most of these studies were conducted on normal fingers. As the etiology of trigger finger is still controversial on whether it is an outcome of tendon nodule or pulley scarring, in this study, a trigger finger model was built combining both the nodule created by silicone gel injection and pulley constriction by external compression...
March 30, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29619360/how-many-trigger-fingers-resolve-spontaneously-without-any-treatment
#12
Daniel McKee, Jan Lalonde, Don Lalonde
Introduction: There is very little information in the literature evaluating the natural history of adult trigger fingers and their rate of spontaneous resolution over time. Methods: A consecutive case series of patients with trigger finger was generated. For each patient, we recorded whether the patient's disease resolved from either no treatment versus active treatment options and over what time period. Results: Three hundred forty-three patients with trigger finger were included in the study...
February 2018: Plastic Surgery
https://www.readbyqxmd.com/read/29598890/closed-loop-intracranial-stimulation-alters-movement-timing-in-humans
#13
Bartlett D Moore, Adam R Aron, Nitin Tandon
BACKGROUND: A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just prior to voluntary movement. OBJECTIVE: Here, we tested a method that detected activity in the human SMA related to impending movement and then delivered cortical stimulation with intracranial electrodes to influence the timing of movement...
March 8, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29589874/genome-editing-in-neuroepithelial-stem-cells-to-generate-human-neurons-with-high-adenosine-releasing-capacity
#14
Daniel Poppe, Jonas Doerr, Marion Schneider, Ruven Wilkens, Julius A Steinbeck, Julia Ladewig, Allison Tam, David E Paschon, Philip D Gregory, Andreas Reik, Christa E Müller, Philipp Koch, Oliver Brüstle
As a powerful regulator of cellular homeostasis and metabolism, adenosine is involved in diverse neurological processes including pain, cognition, and memory. Altered adenosine homeostasis has also been associated with several diseases such as depression, schizophrenia, or epilepsy. Based on its protective properties, adenosine has been considered as a potential therapeutic agent for various brain disorders. Since systemic application of adenosine is hampered by serious side effects such as vasodilatation and cardiac suppression, recent studies aim at improving local delivery by depots, pumps, or cell-based applications...
March 28, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29587785/trigger-wrist-caused-by-avascular-necrosis-of-the-capitate-a-case-report
#15
Yuichiro Matsui, Daisuke Kawamura, Hiroaki Kida, Kanako C Hatanaka, Norimasa Iwasaki
BACKGROUND: Trigger wrist is a rare condition first described by Marti in 1960, and various causes have been reported. The condition mostly occurs with finger flexion and extension, and rarely with flexion and extension of the wrist itself. Avascular necrosis of the capitate is also a rare condition, first described by Jönsson in 1942. While some reports of this condition have been published, little is known about its etiology. Therefore, no established treatment exists. We report a case of trigger wrist caused by avascular necrosis of the capitate...
March 27, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29576086/pamp-responsive-atl-gene-strfp1-and-its-orthologue-nbatl60-positively-regulate-phytophthora-infestans-resistance-in-potato-and-nicotiana-benthamiana
#16
Cheng Zhong, Yajuan Ren, Yetong Qi, Xiaoling Yu, Xintong Wu, Zhendong Tian
Ubiquitination is a post-translational modification that plays a crucial role during the regulation of plant immune signalling. The plant ATL family consists of a large number of putative RING type ubiquitin ligases. We show that potato ATL family gene StRFP1 and its orthologue NbATL60 from N. benthamiana both respond to Phytophthora infestans culture filtrate (CF) and flg22 induction. StRFP1 positively regulates immunity against P. infestans in potato. Ectopic transient expression of StRFP1 or expression of NbATL60 in N...
May 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29567668/muscular-diagnostics-and-the-feasibility-of-microsystem-acupuncture-as-a-potential-adjunct-in-the-treatment-of-painful-temporomandibular-disorders-results-of-a-retrospective-cohort-study
#17
Irmgard Simma, Leopold Simma, Johannes Fleckenstein
AIMS: To investigate the effect of microsystem acupuncture on painful temporomandibular disorders (TMD). METHODS: We retrospectively analysed 887 treatments in 407 TMD-patients (mean age 45±1.5 years), who received microsystem acupuncture (mouth, scalp or fingers) with a focus on oral acupuncture. All patients systematically underwent palpation of specific muscular tender points and their pain rating was assessed on a four-point Likert scale (no pain to strong pain) before and after treatment...
March 22, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29562705/crispr-cas9-technology-as-an-emerging-tool-for-targeting-amyotrophic-lateral-sclerosis-als
#18
REVIEW
Ewa Kruminis-Kaszkiel, Judyta Juranek, Wojciech Maksymowicz, Joanna Wojtkiewicz
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) is a genome editing tool that has recently caught enormous attention due to its novelty, feasibility, and affordability. This system naturally functions as a defense mechanism in bacteria and has been repurposed as an RNA-guided DNA editing tool. Unlike zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), CRISPR/Cas9 takes advantage of an RNA-guided DNA endonuclease enzyme, Cas9, which is able to generate double-strand breaks (DSBs) at specific genomic locations...
March 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29558369/uhrf1-epigenetically-orchestrates-smooth-muscle-cell-plasticity-in-arterial-disease
#19
Leonardo Elia, Paolo Kunderfranco, Pierluigi Carullo, Marco Vacchiano, Floriana Maria Farina, Ignacio Fernando Hall, Stefano Mantero, Cristina Panico, Roberto Papait, Gianluigi Condorelli, Manuela Quintavalle
Adult vascular smooth muscle cells (VSMCs) dedifferentiate in response to extracellular cues such as vascular damage and inflammation. Dedifferentiated VSMCs are proliferative, migratory, less contractile, and can contribute to vascular repair as well as to cardiovascular pathologies such as intimal hyperplasia/restenosis in coronary artery and arterial aneurysm. We here demonstrate the role of ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) as an epigenetic master regulator of VSMC plasticity...
May 7, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29557542/neoblast-enriched-zinc-finger-protein-fir1-triggers-local-proliferation-during-planarian-regeneration
#20
Xiao-Shuai Han, Chen Wang, Fang-Hao Guo, Shuang Huang, Yong-Wen Qin, Xian-Xian Zhao, Qing Jing
Regeneration, relying mainly on resident adult stem cells, is widespread. However, the mechanism by which stem cells initiate proliferation during this process in vivo is unclear. Using planarian as a model, we screened 46 transcripts showing potential function in the regulation of local stem cell proliferation following 48 h regeneration. By analyzing the regeneration defects and the mitotic activity of animals under administration of RNA interference (RNAi), we identified factor for initiating regeneration 1 (Fir1) required for local proliferation...
March 20, 2018: Protein & Cell
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