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Trigger Finger

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https://www.readbyqxmd.com/read/28226857/development-of-a-closed-loop-system-for-tremor-suppression-in-patients-with-parkinson-s-disease
#1
F L Xu, M Z Hao, S Q Xu, Z X Hu, Q Xiao, N Lan, F L Xu, M Z Hao, S Q Xu, Z X Hu, Q Xiao, N Lan, S Q Xu, Z X Hu, Q Xiao, M Z Hao, N Lan, F L Xu
More than 70% of patients suffering Parkinson's disease (PD) exhibit resting tremor in their extremities, hampering their ability to perform daily activities. Based on our earlier studies on corticospinal transmission of tremor signals [10,11], we hypothesize that cutaneous afferents evoked by surface stimulation can produce an inhibitory effect on propriospinal neurons (PN), which in turn will suppress tremor signals passing through the PN. This paper presents the development of a closed-loop system for tremor suppression by transcutaneous electrical nerve stimulation (TENS) of sensory fibers beneath the skin...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226574/a-temperature-controlled-glove-with-non-invasive-arterial-pulse-sensing-for-active-neuro-vascular-assessment
#2
Andrew M Carek, Omer T Inan, Andrew M Carek, Omer T Inan, Andrew M Carek, Omer T Inan
A non-invasive, active neuro-vascular assessment system was developed using a modified temperature-controlled glove and feedback techniques. The glove incorporates local heating and cooling of the hand using multi-point skin temperature measurements as feedback, and thereby induces local and central mechanisms involved in thermoregulation. Electrocardiogram (ECG), photoplethysmogram (PPG) and non-invasive finger-cuff based blood pressure (BP) measurements were used to monitor electrophysiology and hemodynamic changes in response to temperature modulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222331/the-moro-reaction-more-than-a-reflex-a-ritualized-behavior-of-nonverbal-communication
#3
Pierre V Rousseau, Florence Matton, Renaud Lecuyer, Willy Lahaye
OBJECTIVE: To propose a phylogenetic significance to the Moro reflex which remains unexplained since its publication in 1918 because both hands are free at the end of the gesture. METHOD: Among the 75 videos of healthy term newborns we have filmed in a research project on antenatal education to parenthood, we describe a sequence that clearly showed the successive movements of the Moro reflex and we report the occurrence of this reflex in the videos that were recorded from Time 0 of birth defined as the moment that lies between the birth of the thorax and the pelvis of the infant...
February 18, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28216286/rnf8-identified-as-a-co-activator-of-estrogen-receptor-%C3%AE-promotes-cell-growth-in-breast-cancer
#4
Shengli Wang, Hao Luo, Chunyu Wang, Hongmiao Sun, Ge Sun, Ning Sun, Kai Zeng, Huijuan Song, Renlong Zou, Tingting Zhou, Rijiao Cong, Wei Liu, Lei Yang, Da Li, Xin Zhou, Xinping Zhong, Lin Lin, Jiao Jiao, Guangqi Yan, Xue Wang, Xiaojie Min, Liu Cao, Yue Zhao
The ring finger protein 8 (RNF8), a key component of protein complex crucial for DNA-damage response, consists of a forkhead-associated (FHA) domain and a really interesting new gene (RING) domain that enables it to function as an E3 ubiquitin ligase. However, the biological functions of RNF8 in estrogen receptor α (ERα)-positive breast cancer and underlying mechanisms have not been fully defined. Here, we have explored RNF8 as an associated partner of ERα in breast cancer cells, and co-activates ERα-mediated transactivation...
February 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28215221/targeting-chromatin-remodeling-in-inflammation-and-fibrosis
#5
J Yang, B Tian, A R Brasier
Mucosal surfaces of the human body are lined by a contiguous epithelial cell surface that forms a barrier to aerosolized pathogens. Specialized pattern recognition receptors detect the presence of viral pathogens and initiate protective host responses by triggering activation of the nuclear factor κB (NFκB)/RelA transcription factor and formation of a complex with the positive transcription elongation factor (P-TEFb)/cyclin-dependent kinase (CDK)9 and Bromodomain-containing protein 4 (BRD4) epigenetic reader...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28213497/mitochondrial-damage-elicits-a-tcdd-inducible-poly-adp-ribose-polymerase-mediated-antiviral-response
#6
Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of immune modulatory factors and direct the elimination of RNA viruses. Here, we show a unique PRR that mediates antiviral response. Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP ribose) polymerase (TIPARP), a Cysteine3 Histidine (CCCH)-type zinc finger-containing protein, binds to Sindbis virus (SINV) RNA via its zinc finger domain and recruits an exosome to induce viral RNA degradation...
February 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28197159/an-rna-seq-analysis-of-grape-plantlets-grown-in-vitro-reveals-different-responses-to-blue-green-red-led-light-and-white-fluorescent-light
#7
Chun-Xia Li, Zhi-Gang Xu, Rui-Qi Dong, Sheng-Xin Chang, Lian-Zhen Wang, Muhammad Khalil-Ur-Rehman, Jian-Min Tao
Using an RNA sequencing (RNA-seq) approach, we analyzed the differentially expressed genes (DEGs) and physiological behaviors of "Manicure Finger" grape plantlets grown in vitro under white, blue, green, and red light. A total of 670, 1601, and 746 DEGs were identified in plants exposed to blue, green, and red light, respectively, compared to the control (white light). By comparing the gene expression patterns with the growth and physiological responses of the grape plantlets, we were able to link the responses of the plants to light of different spectral wavelengths and the expression of particular sets of genes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28156205/metabolite-and-functional-profile-of-patients-with-cervical-spondylotic-myelopathy
#8
Izabela Aleksanderek, Todd K Stevens, Sandy Goncalves, Robert Bartha, Neil Duggal
OBJECTIVE The goal of this study was to compare the recovery of neuronal metabolism and functional reorganization in the primary motor cortex (M1) between mild and moderate cervical spondylotic myelopathy (CSM) following surgical intervention. METHODS Twenty-eight patients with CSM underwent 3-T MRI scans that included spectroscopy and functional MRI, before surgery and 6 months postsurgery. The classification of severity was based on the modified Japanese Orthopaedic Association questionnaire. Mild and moderate myelopathy were defined by modified Japanese Orthopaedic Association scores > 12 of 18 (n = 15) and 9-12 (n = 13), respectively...
February 3, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28094976/breath-figure-micromolding-approach-for-regulating-the-microstructures-of-polymeric-films-for-triboelectric-nanogenerators
#9
Jianliang Gong, Bingang Xu, Xiaoming Tao
A triboelectric nanogenerator (TENG) is an innovative kind of energy harvester recently developed on the basis of organic materials for converting mechanical energy into electricity through the combined use of the triboelectric effect and electrostatic induction. Polymeric materials and their microstructures play key roles in the generation, accumulation, and retainment of triboelectric charges, which decisively determines the final electric performance of TENGs. Herein we report a simple and efficient breath figure (BF) micromolding approach to rapidly regulate the surface microstructures of polymeric films for the assembly of TENGs...
January 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28071597/three-dimensional-printing-of-a-microneedle-array-on-personalized-curved-surfaces-for-dual-pronged-treatment-of-trigger-finger
#10
Seng Han Lim, Jian Yao Ng, Lifeng Kang
The hand function of patients who suffer from trigger finger can be impaired by the use of traditional splints. There is also a risk of systemic side effects with oral non-steroidal anti-inflammatory drugs (NSAIDs) used for pain relief. Microneedle-assisted transdermal drug delivery offers an attractive alternative for local delivery of NSAIDs. However, traditional microneedle arrays fabricated on flat surfaces are unable to deliver drugs effectively across the undulating skin surface of affected finger(s)...
January 10, 2017: Biofabrication
https://www.readbyqxmd.com/read/28067854/quantitative-assessment-of-first-annular-pulley-and-adjacent-tissues-using-high-frequency-ultrasound
#11
Yi-Hsun Lin, Tai-Hua Yang, Shyh-Hau Wang, Fong-Chin Su
Due to a lack of appropriate image resolution, most ultrasound scanners are unable to sensitively discern the pulley tissues. To extensively investigate the properties of the A1 pulley system and the surrounding tissues for assessing trigger finger, a 30 MHz ultrasound system was implemented to perform in vitro experiments using the hypodermis, A1 pulley, and superficial digital flexor tendon (SDFT) dissected from cadavers. Ultrasound signals were acquired from both the transverse and sagittal planes of each tissue sample...
January 7, 2017: Sensors
https://www.readbyqxmd.com/read/28008672/the-angulata7-gene-encodes-a-dnaj-like-zinc-finger-domain-protein-involved-in-chloroplast-function-and-leaf-development-in-arabidopsis
#12
Tamara Muñoz-Nortes, José Manuel Pérez-Pérez, María Rosa Ponce, Héctor Candela, José Luis Micol
The characterization of mutants with altered leaf shape and pigmentation has previously allowed the identification of nuclear genes that encode plastid-localized proteins that perform essential functions in leaf growth and development. A large-scale screen previously allowed us to isolate ethyl methanesulfonate-induced mutants with small rosettes and pale green leaves with prominent marginal teeth, which were assigned to a phenotypic class that we dubbed Angulata. The molecular characterization of the 12 genes assigned to this phenotypic class should help us to advance our understanding of the still poorly understood relationship between chloroplast biogenesis and leaf morphogenesis...
December 23, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28002865/percutaneous-release-procedures-trigger-finger-and-carpal-tunnel
#13
Gajan Rajeswaran, Jeremiah C Healy, Justin C Lee
Trigger digit and carpal tunnel syndrome are both conditions traditionally treated with open surgery but are potentially amenable to curative treatment using percutaneous techniques. The advantages of minimally invasive techniques are lower risk of wound breakdown and infection, quicker healing, reduced postprocedural pain, reduced complications, and a quicker return to normal activity. The advent of high-resolution ultrasound has allowed percutaneous release procedures for these conditions to be developed and performed with a potential for a reduced risk of complications and an increased likelihood of success...
November 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28002861/injectable-corticosteroids-take-precautions-and-use-caution
#14
Véronique Freire, Nathalie J Bureau
Corticosteroids are routinely injected into soft tissues, tendon sheaths, bursae, and joints. These anti-inflammatory agents have different potency and solubility, and solubility is inversely correlated with the duration of action. Corticosteroids carry a low risk of complications but commonly cause systemic and local adverse effects. The use of intra-articular corticosteroid injections in the treatment of inflammatory arthritis and osteoarthritis is well established. Evidence also supports the use of injectable corticosteroids in the treatment of inflammatory tenosynovitis and bursitis associated with rheumatic diseases, trigger finger and de Quervain disease, and carpal tunnel syndrome...
November 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28002675/flexible-all-inorganic-actuators-based-on-vanadium-dioxide-and-carbon-nanotube-bimorphs
#15
He Ma, Jiwei Hou, Xuewen Wang, Jin Zhang, Zhiquan Yuan, Lin Xiao, Yang Wei, Shoushan Fan, Kaili Jiang, Kai Liu
Flexible actuators responsive to multiple stimuli are much desired in wearable electronics. However, general designs containing organic materials are usually subject to slow response and limited lifetime, or high triggering threshold. In this study, we develop flexible, all-inorganic actuators based on bimorph structures composed of vanadium dioxide (VO2) and carbon nanotube (CNT) thin films. The drastic, reversible phase transition of VO2 drives the actuators to deliver giant amplitude, fast response up to ∼100 Hz, and long lifetime more than 1 000 000 actuation cycles...
December 27, 2016: Nano Letters
https://www.readbyqxmd.com/read/27979461/evaluating-the-reliability-of-equilibrium-dissolution-assumption-from-residual-gasoline-in-contact-with-water-saturated-sands
#16
Greg Lekmine, Kaveh Sookhak Lari, Colin D Johnston, Trevor P Bastow, John L Rayner, Greg B Davis
Understanding dissolution dynamics of hazardous compounds from complex gasoline mixtures is a key to long-term predictions of groundwater risks. The aim of this study was to investigate if the local equilibrium assumption for BTEX and TMBs (trimethylbenzenes) dissolution was valid under variable saturation in two dimensional flow conditions and evaluate the impact of local heterogeneities when equilibrium is verified at the scale of investigation. An initial residual gasoline saturation was established over the upper two-thirds of a water saturated sand pack...
January 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/27955967/digital-necrosis-after-lidocaine-and-epinephrine-injection-in-the-flexor-tendon-sheath-without-phentolamine-rescue
#17
Jacques X Zhang, Jason Gray, Donald H Lalonde, Nicholas Carr
The literature generally supports the safety of epinephrine injection in the digits, but recent case reports describe ischemic adverse events associated with the use of lidocaine and epinephrine in which phentolamine rescue was not performed. We present a case of finger necrosis and subsequent amputation in a patient after 1% lidocaine with 1:100,000 epinephrine was injected in the fat and flexor sheaths in the palm for a 3-finger trigger release. Phentolamine rescue was not performed. All surgeons who use epinephrine in the finger should be prepared to reverse vasoconstriction with phentolamine rescue if there is persistently inadequate perfusion of the fingertip...
February 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27940039/management-strategy-for-congenital-thumb-differences-in-paediatric-patients
#18
REVIEW
G Dautel
Congenital thumb anomalies are common and have a major impact given the specific functional role of the thumb. They may occur alone or as part of a multiple congenital anomaly syndrome. The primary goal of surgical management is to improve or restore pincer grip. In patients with 'congenital' trigger thumb, the A1 pulley must be released if the interphalangeal joint remains in fixed flexion. Thumb duplication is generally managed by reconstruction of the thumb from the predominant (ulnar-based) digit; the accessory (radial-based) digit is excised after collection of its tissue components needed for the reconstruction programme...
December 8, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27914614/outcomes-of-percutaneous-trigger-finger-release%C3%A2-with-concurrent-steroid-injection
#19
Wen-Chih Liu, Chun-Kuan Lu, Yu-Chuan Lin, Peng-Ju Huang, Gau-Tyan Lin, Yin-Chih Fu
Percutaneous release (PR) of the A1 pulley is a quick, safe, and minimally invasive procedure for treating trigger fingers. The purpose of this study is to identify if PR with additional steroid injections can shorten the recovery to reach unlimited range of motion. Between January 2013 and December 2013, we included 432 trigger fingers with actively correctable triggering or severer symptoms without previous surgical release or steroid injections from two hand clinic offices (A and B). The same experienced surgeon performed PR at the office...
December 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27913950/mechanics-reveals-the-biological-trigger-in-wrinkly-fingers
#20
P Sáez, A M Zöllner
Fingertips wrinkle due to long exposure to water. The biological reason for this morphological change is unclear and still not fully understood. There are two main hypotheses for the underlying mechanism of fingertip wrinkling: the 'shrink' model (in which the wrinkling is driven by the contraction of the lower layers of skin, associated with the shrinking of the underlying vasculature), and the 'swell' model (in which the wrinkling is driven by the swelling of the upper layers of the skin, associated with osmosis)...
December 2, 2016: Annals of Biomedical Engineering
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