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Trigger Finger

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https://www.readbyqxmd.com/read/27880725/mouse-sirt3-promotes-autophagy-in-angii-induced-myocardial-hypertrophy-through-the-deacetylation-of-foxo1
#1
Jingyuan Li, Tongshuai Chen, Ming Xiao, Na Li, Shujian Wang, Hongyan Su, Xiaobin Guo, Hui Liu, Fangying Yan, Yi Yang, Yun Zhang, Peili Bu
Sirt3, a mitochondrial NAD+-dependent histone deacetylase, is the only member proven to promote longevity in mammalian Sirtuin family. The processed short form of Sirt3 has been demonstrated to target many mediators of energy metabolism and mitochondrial stress adaptive program. Autophagy serves as a dynamic recycling mechanism and provides energy or metabolic substrates. Among the mechanisms triggered by cardiac stress, opinions vary as to whether autophagy is a protective or detrimental response. Here, by inducing the Sirt3-knockout mice to myocardial hypertrophy with chronic angiotensin II infusion for four weeks, we determined the role of Sirt3 in myocardial hypertrophy and autophagy...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27847849/assessment-of-decisional-conflict-about-the-treatment-of-trigger-finger-comparing-patients-and-physicians
#2
Michiel G J S Hageman, Anne-Carolin Döring, Silke A Spit, Thierry G Guitton, David Ring
BACKGROUND: As an early step in the development of a decision aid for idiopathic trigger finger (TF) we were interested in the level of decisional conflict experienced by patients and hand surgeons. This study tested the null hypothesis that there is no difference in decisional conflict between patients with one or more idiopathic trigger fingers and hand surgeons. Secondary analyses address the differences between patients and surgeons regarding the influence of the DCS-subcategories on the level of decisional conflict, as well as the influence of patient and physician demographics, the level of self-efficacy, and satisfaction with care on decisional conflict...
October 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27843364/radial-extracorporeal-shockwave-therapy-for-the-treatment-of-finger-tenosynovitis-trigger-digit
#3
Nikos Malliaropoulos, Rosanna Jury, Debasish Pyne, Nat Padhiar, Jennifer Turner, Vasileios Korakakis, Maria Meke, Heinz Lohrer
INTRODUCTION: Stenosing tenosynovitis that is characterized by the inability to flex the digit smoothly, usually leads to prolonged rehabilitation or surgery. STUDY DESIGN: This case series is a retrospective cohort study. PURPOSE: The aim of this case series was to evaluate the effectiveness of radial extracorporeal shockwave therapy (rESWT) for the treatment of stenosing tenosynovitis of the digital flexor tendon (trigger digit). METHODS: A retrospective analysis of 44 patients (49 fingers) treated with an individually adapted rESWT protocol was conducted...
2016: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/27830943/long-term-functional-outcome-of-trigger-finger
#4
Danit Langer, Shai Luria, Michael Michailevich, Adina Maeir
PURPOSE: The purpose of this study was to explore the long-term functional outcomes of trigger finger (TF) as perceived by the patient. METHODS: Three study groups were included in the study: prolonged follow up TF group (at least 1-year post-treatment) (PF-TF), patients with acute TF and a control group. The first group was recruited retrospectively and included all patients who were diagnosed with TF in one orthopedic clinic and were contacted by phone, 109 agreed to participate...
November 10, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27830829/cellulase-from-trichoderma-harzianum-interacts-with-roots-and-triggers-induced-systemic-resistance-to-foliar-disease-in-maize
#5
Kandasamy Saravanakumar, Lili Fan, Kehe Fu, Chuanjin Yu, Meng Wang, Hai Xia, Jianan Sun, Yaqian Li, Jie Chen
Trichoderma harzianum is well known to exhibit induced systemic resistance (ISR) to Curvularia leaf spot. We previously reported that a C6 zinc finger protein (Thc6) is responsible for a major contribution to the ISR to the leaf disease, but the types of effectors and the signals mediated by Thc6 from Trichoderma are unclear. In this work, we demonstrated that two hydrolases, Thph1 and Thph2, from T. harzianum were regulated by Thc6. Furthermore, an electrophoretic mobility shift assay (EMSA) study revealed that Thc6 regulated mRNA expression by binding to GGCTAA and GGCTAAA in the promoters of the Thph1 and Thph2 genes, respectively...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27826738/transcription-factor-pex1-modulates-extracellular-matrix-turnover-through-regulation-of-mmp-9-expression
#6
Alicia Jurado Acosta, Jaana Rysä, Zoltan Szabo, Anne-Mari Moilanen, Hiba Komati, Mona Nemer, Heikki Ruskoaho
The phenylephrine-induced complex-1 (PEX1) transcription factor, also known as zinc-finger protein 260 (Zfp260), is an effector of endothelin-1 and α1-adrenergic signaling in cardiac hypertrophy. However, the role of PEX1 in transcriptional regulation of myocardial remodeling remains largely unknown. In the present study, we used PEX1 gain- and loss-of-function to examine the effects of PEX1 on left ventricular remodeling. Adenoviral constructs expressing PEX1, antisense PEX1, or LacZ were delivered by local injection into the anterior wall of the left ventricle in Sprague-Dawley rats...
November 8, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27817941/trigger-finger-caused-by-extraskeletal-chondroma
#7
Karl Schwaiger, Florian Ensat, Daniel Neurreiter, Gottfried Wechselberger, Michaela Hladik
Chondroma is a relatively rare, but well-reported benign neoplasm. This lesion normally occurs attached to bone; however, they may be rarely found without association to bone and embedded in soft tissue. The authors describe the case of a 76-year-old man in whom flexor tendon triggering was associated with an extraskeletal chondroma between the annular ligament and the flexor tendon.
November 3, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27816777/concurrent-use-of-somatotopic-and-external-reference-frames-in-a-tactile-mislocalization-task
#8
Luigi Tamè, Anja Wühle, Caroline D Petri, Francesco Pavani, Christoph Braun
Localizing tactile stimuli on our body requires sensory information to be represented in multiple frames of reference along the sensory pathways. These reference frames include the representation of sensory information in skin coordinates, in which the spatial relationship of skin regions is maintained. The organization of the primary somatosensory cortex matches such somatotopic reference frame. In contrast, higher-order representations are based on external coordinates, in which body posture and gaze direction are taken into account in order to localise touch in other meaningful ways according to task demands...
November 2, 2016: Brain and Cognition
https://www.readbyqxmd.com/read/27807072/introduction-of-id2-enhances-invasiveness-in-id2-null-oral-squamous-cell-carcinoma-cells-via-the-snail-axis
#9
Y U Kamata, Tomoki Sumida, Yosuke Kobayashi, Akiko Ishikawa, Wataru Kumamaru, Yoshihide Mori
AIM: Inhibitor of DNA-binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors that generally stimulate cell proliferation and inhibit differentiation. However, the role of ID2 in cancer progression remains ambiguous. Here, we investigated the function of ID2 in ID2-null oral squamous cell carcinoma (OSCC) cells. MATERIALS AND METHODS: We introduced an ID2 cDNA construct into ID2-null OSCC cells and compared them with empty-vector-transfected cells in terms of cell proliferation, invasion, and activity and expression of matrix metalloproteinase (MMP)...
November 2016: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27747514/collagenase-treatment-in-dupuytren-contractures-a-review-of-the-current-state-versus-future-needs
#10
Ilse Degreef
Dupuytren disease is highly prevalent and the finger contractures can be very extensile, compromising the patients' hand function. To restore full function, contractures have been addressed by cutting the causative strands for nearly 200 years, ever since Baron Guillaume Dupuytren demonstrated his technique at the beginning of the nineteenth century. Surgery can be minimal (fasciotomy) or quite invasive (fasciectomy and even skin replacement). However, in the last decade translational research has introduced the non-surgical technique of enzymatic fasciotomy with collagenase injections...
June 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27747009/a-convenient-method-for-identifying-a-small-pulmonary-nodule-using-a-dyed-swab-and-geometric-mapping
#11
Mitsuhiro Kamiyoshihara, Takashi Ibe, Natsuko Kawatani, Fumi Ohsawa, Ryohei Yoshikawa, Kimihiro Shimizu
BACKGROUND: Computed tomography (CT)-guided lung needle marking is useful to identify pulmonary nodules. However, certain complications sometimes trigger severe after-effects or death. So, we present a convenient and safe method by which small pulmonary nodules can be identified using a particular dye [2% (w/v) gentian violet]. METHODS: A patient is initially placed in the lateral operative position. Under CT guidance, a "magic marker" is used to identify the skin above the pulmonary nodule...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27741253/the-sense-of-agency-as-tracking-control
#12
Emilie A Caspar, Andrea Desantis, Zoltan Dienes, Axel Cleeremans, Patrick Haggard
Does sense of agency (SoA) arise merely from action-outcome associations, or does an additional real-time process track each step along the chain? Tracking control predicts that deviant intermediate steps between action and outcome should reduce SoA. In two experiments, participants learned mappings between two finger actions and two tones. In later test blocks, actions triggered a robot hand moving either the same or a different finger, and also triggered tones, which were congruent or incongruent with the mapping...
2016: PloS One
https://www.readbyqxmd.com/read/27740459/modified-percutaneous-trigger-finger-release
#13
J-D Werthel, M Cortez, B T Elhassan
: Stenosing tenosynovitis or trigger finger is one of the most common disorders that affect the flexor tendon apparatus of the hand. Percutaneous release has been previously reported to be easier, quicker, less invasive and less costly than open surgery. The purpose of this study was to report the outcome of an alternative percutaneous trigger finger release technique. From March 2008 to January 2014, 92 patients (128 fingers) who underwent the alternative percutaneous trigger finger release, with a minimum of 6 months follow-up were included...
June 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27726037/on-the-morphological-stability-of-multicellular-tumour-spheroids-growing-in-porous-media
#14
Chiara Giverso, Pasquale Ciarletta
Multicellular tumour spheroids (MCTSs) are extensively used as in vitro system models for investigating the avascular growth phase of solid tumours. In this work, we propose a continuous growth model of heterogeneous MCTSs within a porous material, taking into account a diffusing nutrient from the surrounding material directing both the proliferation rate and the mobility of tumour cells. At the time scale of interest, the MCTS behaves as an incompressible viscous fluid expanding inside a porous medium. The cell motion and proliferation rate are modelled using a non-convective chemotactic mass flux, driving the cell expansion in the direction of the external nutrients' source...
October 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27717978/high-resolution-ultrasound-in-the-diagnosis-of-trigger-finger-and-evaluation-of-response-to-steroid-injection
#15
Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Yoshifumi Harada, Fumiaki Takase, Masahiro Kurosaka, Takeshi Kokubu
OBJECTIVE: No studies have reported the use of ultrasound for the evaluation of trigger finger after steroid injection. We evaluated the clinical features and ultrasound appearance of trigger finger before and after steroid injection under ultrasound guidance. MATERIALS AND METHODS: Thirty-eight digits with triggering were included. A single steroid injection into the tendon sheath was administered. Ultrasound findings and clinical symptoms, including pain, triggering, and the Quinnell score, were analyzed before injection and at 1 and 3 weeks after injection...
December 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27717446/arginine-rich-motif-tandem-ccch-zinc-finger-proteins-in-plant-stress-responses-and-post-transcriptional-regulation-of-gene-expression
#16
Jyan-Chyun Jang
Tandem CCCH zinc finger (TZF) proteins are evolutionarily conserved regulators of gene expression at the post-transcriptional level. TZFs target AU-rich RNA elements at 3' un-translated region and recruit catabolic machineries to trigger mRNA degradation. The plant TZF families are over-represented by a class of proteins with a unique TZF domain preceded by an arginine-rich motif (RR-TZF). RR-TZF proteins are mainly involved in hormone- and environmental cues-mediated plant growth and stress responses. Numerous reports have suggested that RR-TZF proteins control seed germination, plant size, flowering time, and biotic and abiotic stress responses via regulation of gene expression...
November 2016: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/27692801/risk-of-prolonged-opioid-use-among-opioid-na%C3%A3-ve-patients-following-common-hand-surgery-procedures
#17
Shepard P Johnson, Kevin C Chung, Lin Zhong, Melissa J Shauver, Michael J Engelsbe, Chad Brummett, Jennifer F Waljee
PURPOSE: To evaluate prolonged opioid use in opioid-naïve patients after common hand surgery procedures in the United States. METHODS: We studied insurance claims from the Truven MarketScan databases to identify opioid-naïve adult patients (no opioid exposure 11 months before the perioperative period) who underwent an elective (carpal tunnel release, carpometacarpal arthroplasty/arthrodesis, cubital tunnel release, or trigger finger release) or trauma-related (closed distal radius fracture fixation, flexor tendon repair, metacarpal fracture fixation, or phalangeal fracture fixation) hand surgery procedure between 2010 and 2012 (N = 77,573 patients)...
September 7, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27671766/cost-of-immediate-surgery-versus-non-operative-treatment-for-trigger-finger-in-diabetic-patients
#18
Gaurav Aman Luther, Praveen Murthy, Philip E Blazar
PURPOSE: As health care costs continue to rise, providers must increasingly identify and implement cost-effective practice measures without sacrificing quality of care. Corticosteroid injections are an established treatment for trigger finger; however, numerous clinical trials have documented the limited efficacy of these injections in the diabetic population. Furthermore, the most cost-effective treatment strategy for diabetic trigger finger has not been determined. The purpose of this study was to perform a decision analysis to identify the least costly strategy for effective treatment of diabetic trigger finger using existing evidence in the literature...
September 23, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27651971/severe-primary-raynaud-s-disease-treated-with-rituximab
#19
Mohammed Shabrawishi, Abdurahman Albeity, Hani Almoallim
Raynaud's phenomenon refers to reversible spasms of the peripheral arterioles that can be primary Raynaud's phenomenon (PRP) or secondary Raynaud's phenomenon (SRP) to underlying connective tissue disease, both of which are characterized by a triphasic color response triggered by cold exposure or stress. PRP is typically a benign disease, whereas SRP may progress into digital ulcers and/or gangrene. Here, we report a case of a 55-year-old female diagnosed with PRP 7 years ago. Treatment with first-line agents, including calcium channel blocker, aspirin, and phosphodiesterase inhibitor, did not control her symptoms, which progressed to digital ulceration and gangrene...
2016: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/27651958/spider-bite-a-rare-case-of-acute-necrotic-arachnidism-with-rapid-and-fatal-evolution
#20
Mario Pezzi, Anna Maria Giglio, Annamaria Scozzafava, Orazio Filippelli, Giuseppe Serafino, Mario Verre
The spider bites are quite frequent and often resolve quickly without leaving outcomes; only some species are capable of causing necrotic and systematic lesions in humans. Among them, we should mention the genus Loxosceles. The venom released from the spider bite of Loxosceles species is composed of proteins, enzymes, and nonenzymatic polypeptides. The phospholipase D family was identified as the active component of the venom. This family of enzymes is responsible for the local and systemic effects observed in loxoscelism...
2016: Case Reports in Emergency Medicine
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