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Trigger Finger

Ilse Degreef
Dupuytren disease is highly prevalent and the finger contractures can be very extensile, compromising the patients' hand function. To restore full function, contractures have been addressed by cutting the causative strands for nearly 200 years, ever since Baron Guillaume Dupuytren demonstrated his technique at the beginning of the nineteenth century. Surgery can be minimal (fasciotomy) or quite invasive (fasciectomy and even skin replacement). However, in the last decade translational research has introduced the non-surgical technique of enzymatic fasciotomy with collagenase injections...
June 2016: Rheumatol Ther
Mitsuhiro Kamiyoshihara, Takashi Ibe, Natsuko Kawatani, Fumi Ohsawa, Ryohei Yoshikawa, Kimihiro Shimizu
BACKGROUND: Computed tomography (CT)-guided lung needle marking is useful to identify pulmonary nodules. However, certain complications sometimes trigger severe after-effects or death. So, we present a convenient and safe method by which small pulmonary nodules can be identified using a particular dye [2% (w/v) gentian violet]. METHODS: A patient is initially placed in the lateral operative position. Under CT guidance, a "magic marker" is used to identify the skin above the pulmonary nodule...
September 2016: Journal of Thoracic Disease
Emilie A Caspar, Andrea Desantis, Zoltan Dienes, Axel Cleeremans, Patrick Haggard
Does sense of agency (SoA) arise merely from action-outcome associations, or does an additional real-time process track each step along the chain? Tracking control predicts that deviant intermediate steps between action and outcome should reduce SoA. In two experiments, participants learned mappings between two finger actions and two tones. In later test blocks, actions triggered a robot hand moving either the same or a different finger, and also triggered tones, which were congruent or incongruent with the mapping...
2016: PloS One
J-D Werthel, M Cortez, B T Elhassan
: Stenosing tenosynovitis or trigger finger is one of the most common disorders that affect the flexor tendon apparatus of the hand. Percutaneous release has been previously reported to be easier, quicker, less invasive and less costly than open surgery. The purpose of this study was to report the outcome of an alternative percutaneous trigger finger release technique. From March 2008 to January 2014, 92 patients (128 fingers) who underwent the alternative percutaneous trigger finger release, with a minimum of 6 months follow-up were included...
June 2016: Hand Surgery and Rehabilitation
Chiara Giverso, Pasquale Ciarletta
Multicellular tumour spheroids (MCTSs) are extensively used as in vitro system models for investigating the avascular growth phase of solid tumours. In this work, we propose a continuous growth model of heterogeneous MCTSs within a porous material, taking into account a diffusing nutrient from the surrounding material directing both the proliferation rate and the mobility of tumour cells. At the time scale of interest, the MCTS behaves as an incompressible viscous fluid expanding inside a porous medium. The cell motion and proliferation rate are modelled using a non-convective chemotactic mass flux, driving the cell expansion in the direction of the external nutrients' source...
October 2016: European Physical Journal. E, Soft Matter
Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Yoshifumi Harada, Fumiaki Takase, Masahiro Kurosaka, Takeshi Kokubu
OBJECTIVE: No studies have reported the use of ultrasound for the evaluation of trigger finger after steroid injection. We evaluated the clinical features and ultrasound appearance of trigger finger before and after steroid injection under ultrasound guidance. MATERIALS AND METHODS: Thirty-eight digits with triggering were included. A single steroid injection into the tendon sheath was administered. Ultrasound findings and clinical symptoms, including pain, triggering, and the Quinnell score, were analyzed before injection and at 1 and 3 weeks after injection...
October 8, 2016: Skeletal Radiology
Jyan-Chyun Jang
Tandem CCCH zinc finger (TZF) proteins are evolutionarily conserved regulators of gene expression at the post-transcriptional level. TZFs target AU-rich RNA elements at 3' un-translated region and recruit catabolic machineries to trigger mRNA degradation. The plant TZF families are over-represented by a class of proteins with a unique TZF domain preceded by an arginine-rich motif (RR-TZF). RR-TZF proteins are mainly involved in hormone- and environmental cues-mediated plant growth and stress responses. Numerous reports have suggested that RR-TZF proteins control seed germination, plant size, flowering time, and biotic and abiotic stress responses via regulation of gene expression...
November 2016: Plant Science: An International Journal of Experimental Plant Biology
Shepard P Johnson, Kevin C Chung, Lin Zhong, Melissa J Shauver, Michael J Engelsbe, Chad Brummett, Jennifer F Waljee
PURPOSE: To evaluate prolonged opioid use in opioid-naïve patients after common hand surgery procedures in the United States. METHODS: We studied insurance claims from the Truven MarketScan databases to identify opioid-naïve adult patients (no opioid exposure 11 months before the perioperative period) who underwent an elective (carpal tunnel release, carpometacarpal arthroplasty/arthrodesis, cubital tunnel release, or trigger finger release) or trauma-related (closed distal radius fracture fixation, flexor tendon repair, metacarpal fracture fixation, or phalangeal fracture fixation) hand surgery procedure between 2010 and 2012 (N = 77,573 patients)...
September 7, 2016: Journal of Hand Surgery
Gaurav Aman Luther, Praveen Murthy, Philip E Blazar
PURPOSE: As health care costs continue to rise, providers must increasingly identify and implement cost-effective practice measures without sacrificing quality of care. Corticosteroid injections are an established treatment for trigger finger; however, numerous clinical trials have documented the limited efficacy of these injections in the diabetic population. Furthermore, the most cost-effective treatment strategy for diabetic trigger finger has not been determined. The purpose of this study was to perform a decision analysis to identify the least costly strategy for effective treatment of diabetic trigger finger using existing evidence in the literature...
September 23, 2016: Journal of Hand Surgery
Mohammed Shabrawishi, Abdurahman Albeity, Hani Almoallim
Raynaud's phenomenon refers to reversible spasms of the peripheral arterioles that can be primary Raynaud's phenomenon (PRP) or secondary Raynaud's phenomenon (SRP) to underlying connective tissue disease, both of which are characterized by a triphasic color response triggered by cold exposure or stress. PRP is typically a benign disease, whereas SRP may progress into digital ulcers and/or gangrene. Here, we report a case of a 55-year-old female diagnosed with PRP 7 years ago. Treatment with first-line agents, including calcium channel blocker, aspirin, and phosphodiesterase inhibitor, did not control her symptoms, which progressed to digital ulceration and gangrene...
2016: Case Reports in Rheumatology
Mario Pezzi, Anna Maria Giglio, Annamaria Scozzafava, Orazio Filippelli, Giuseppe Serafino, Mario Verre
The spider bites are quite frequent and often resolve quickly without leaving outcomes; only some species are capable of causing necrotic and systematic lesions in humans. Among them, we should mention the genus Loxosceles. The venom released from the spider bite of Loxosceles species is composed of proteins, enzymes, and nonenzymatic polypeptides. The phospholipase D family was identified as the active component of the venom. This family of enzymes is responsible for the local and systemic effects observed in loxoscelism...
2016: Case Reports in Emergency Medicine
Huajian Zhang, Tongyao Zhao, Peitong Zhuang, Zhiqiang Song, Hui Du, Zhaozhao Tang, Zhimou Gao
SsCut, which functions as an elicitor, can induce plant immunity. In this study, we utilized Nicotiana benthamiana and virus-induced gene silencing to individually decrease the expression of over 2,500 genes. Using this forward genetics approach, several genes were identified that, when silenced, compromised SsCut-triggered cell death based on a cell death assay. A C2H2-type zinc finger gene was isolated from N. benthamiana Sequence analysis indicated that the gene encodes a 27-kDa protein with 253 amino acids containing two typical C2H2-type zinc finger domains; this gene was named NbCZF1 We found that SsCut-induced cell death could be inhibited by virus-induced gene silencing of NbCZF1 in N...
September 20, 2016: Plant & Cell Physiology
Gert Cornelissen, Javier Palacios-Fenech
In this paper we study consumers' interest in acquiring and displaying expensive luxury products. Based on recent insights in consumer psychology, which build on developments in evolutionary biology, we consider luxury products as "costly signals": wasteful and costly goods, whose purpose is to communicate one's biological fitness, and social status, to others. In line with previous research, we show that experiences that trigger mate attraction goals (Study 1: Exposure to others in bathing outfit) or status display goals (Study 2: Experiencing a vicarious victory of one's favorite sports team) can increase people's interest in luxury products...
2016: Spanish Journal of Psychology
Soon Young Shin, Seunghyun Ahn, Dongsoo Koh, Yoongho Lim
(E)-1-(2-hydroxyphenyl)-3-(2-methoxynaphthalen-1-yl)prop-2-en-1-one (HMP) is a novel synthetic naphthal chalcone derivative. The aim of this study was to investigate the mode of action underlying the antitumor activity of HMP. We found that treatment with HMP potently inhibited the clonogenicity and triggered cell death in HCT116 colon cancer cells. Flow cytometry showed that HMP induced an increase in the population of sub-G0/G1-phase cells. Annexin V binding assay revealed that HMP triggered apoptotic cell death...
October 28, 2016: Biochemical and Biophysical Research Communications
Huhu Cheng, Fei Zhao, Jiangli Xue, Gaoquan Shi, Lan Jiang, Liangti Qu
Graphene, because of its superior electrical/thermal conductivity, high surface area, excellent mechanical flexibility and stability, is currently receiving significant attentions and benefits to fabricate actuator devices. Here, a sole graphene oxide (GO) film responsive actuator with integrated self-detecting sensor has been developed. The film exhibits asymmetric surface structure on its two sides, making a promising actuation ability triggered by multi stimulus such as moisture, thermals and infrared light...
September 16, 2016: ACS Nano
Arezu Jahani-Asl, Cheng Cheng, Chi Zhang, Azad Bonni
Intellectual disability encompasses a large set of neurodevelopmental disorders of cognition that are more common in males than females. Although mutations in over 100 X-linked genes associated to intellectual disability have been identified, only a few X-linked intellectual disability proteins have been intensively studied. Hence, the molecular mechanisms underlying the majority of X-linked intellectual disability disorders remain poorly understood. A substantial fraction of X-linked intellectual disability genes encode nuclear proteins, suggesting that elucidating their functions in the regulation of transcription may provide novel insights into the pathogenesis of intellectual disability...
September 12, 2016: Neurobiology of Disease
Takaaki Mori, Nobuaki Inoue
A previously healthy 1-year-old boy suddenly began choking and coughing after ingesting a coin. The child's mother attempted to extract the coin by inserting her fingers in his mouth and sweeping the oral cavity. The mother felt the object momentarily with her fingertips but was unable to retrieve it, and brought her son to a local hospital for assistance. The patient was referred to our emergency department (ED) for possible oesophageal obstruction by a foreign body based on the X-ray findings. On arrival at our ED, the child exhibited mild gagging but presented no respiratory symptoms and normal pulmonary examination...
2016: BMJ Case Reports
Michiyuki Kawakami, Toshiyuki Fujiwara, Junichi Ushiba, Atsuko Nishimoto, Kaoru Abe, Kaoru Honaga, Atsuko Nishimura, Katsuhiro Mizuno, Mitsuhiko Kodama, Yoshihisa Masakado, Meigen Liu
BACKGROUND: Hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy improved paretic upper extremity motor function in patients with severe to moderate hemiparesis. We hypothesized that brain machine interface (BMI) training would be able to increase paretic finger muscle activity enough to apply HANDS therapy in patients with severe hemiparesis, whose finger extensor was absent. OBJECTIVE: The aim of this study was to assess the efficacy of BMI training followed by HANDS therapy in patients with severe hemiparesis...
September 21, 2016: Restorative Neurology and Neuroscience
Cosma Calderaro, Matteo Guzzini, Marco Pagnottelli, Mattia Fabbri, Dario Perugia
We report a case of post-traumatic trigger finger due to a partial longitudinal tear of the flexor digitorum superficialis. The suspect came from the clinical history and the young age of the patient. It was successfully treated with tendon flap suture and pulley A1 release.
2016: Case Reports in Plastic Surgery & Hand Surgery
Erika Gunnar, Caroline Bivik, Annika Starkenberg, Stefan Thor
Neural progenitors typically divide asymmetrically to renew themselves, while producing daughters with more limited potential. In the Drosophila embryonic ventral nerve cord, neuroblasts initially produce daughters that divide once to generate two neurons/glia (type I proliferation mode). Subsequently, many neuroblasts switch to generating daughters that differentiate directly (type 0). This programmed type I>0 switch is controlled by Notch signaling, triggered at a distinct point of lineage progression in each neuroblast...
August 30, 2016: Development
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