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https://www.readbyqxmd.com/read/28431138/cardiovascular-outcome-trials-in-patients-with-chronic-kidney-disease-challenges-associated-with-selection-of-patients-and-endpoints
#1
Patrick Rossignol, Rajiv Agarwal, Bernard Canaud, Alan Charney, Gilles Chatellier, Jonathan C Craig, William C Cushman, Ronald T Gansevoort, Bengt Fellström, Dahlia Garza, Nicolas Guzman, Frank A Holtkamp, Gerard M London, Ziad A Massy, Alexandre Mebazaa, Peter G M Mol, Marc A Pfeffer, Yves Rosenberg, Luis M Ruilope, Jonathan Seltzer, Amil M Shah, Salim Shah, Bhupinder Singh, Bergur V Stefánsson, Norman Stockbridge, Wendy Gattis Stough, Kristian Thygesen, Michael Walsh, Christoph Wanner, David G Warnock, Christopher S Wilcox, Janet Wittes, Bertram Pitt, Aliza Thompson, Faiez Zannad
Although cardiovascular disease is a major health burden for patients with chronic kidney disease, most cardiovascular outcome trials have excluded patients with advanced chronic kidney disease. Moreover, the major cardiovascular outcome trials that have been conducted in patients with end-stage renal disease have not demonstrated a treatment benefit. Thus, clinicians have limited evidence to guide the management of cardiovascular disease in patients with chronic kidney disease, particularly those on dialysis...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28429681/microwave-diathermy-in-physiotherapy-units-a-survey-on-spatial-and-time-heterogeneity-of-electromagnetic-field
#2
Andreas Andrikopoulos, Adam Adamopoulos, Ioannis Seimenis, Constantinos Miltiadis Koutsojannis
Microwave diathermy (MWD) is a therapeutic system that is in use for some decades now in all physiotherapy settings, according to national facility establishment regulations. Diathermy devices probably lack validity, as working time passes, introducing the need of control/reset of the device by qualified personnel, in order to maintain its effectiveness in sessions and accurately deliver the energy output the physiotherapist asks for. However, while in the field of physical therapy MWD has been a vital part for practicing the profession of physiotherapist, there is not a clear evidence of health burden due to incorrect usability...
April 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28428642/-technology-and-prevention-in-the-era-of-mobile-health-applications-for-cancer-screening-programs
#3
Fabrizio Bert, Maria Rosaria Gualano, Salvatore Clemente, Giulia Villa, Roberta Siliquini
The Italian national health system provides screening to detect breast, colorecatal and cervical cancers, however, population adherence is not as high as expected. Smartphones and their applications (apps) could be used as a tool to communicate with the population and to help improve adherence. The aim of this study was to analyze the features and functions of smartphone applications aimed at secondary prevention of oncological diseases. In February 2016, we reviewed online app stores, using specific key-words, to search for available apps for cancer screening...
January 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28426111/importation-of-yellow-fever-into-china-assessing-travel-patterns
#4
Annelies Wilder-Smith, W Y Leong
Rapid increase in trade and a growing air passenger market encourages high travel volume between the regions associated with increasing risks of such importations including China. Eleven Chinese workers infected during the 2016 yellow fever (YF) outbreak in Angola imported YF into China highlighting the potential for spread into Asia. Using outbound and inbound travel data, we assessed travel patterns from and to YF endemic countries in relation to China. Among YF endemic countries, Angola has the second highest number of travellers into China and also receives the second highest number of Chinese visitors...
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28421889/overall-assessment-of-human-research-and-ethics-committees-in-the-united-arab-emirates
#5
Mahera Abdulrahman, Satish Chandrasekhar Nair
Growing demand for human health research in the United Arab Emirates (UAE) has prompted the need to develop a robust research ethics oversight. Examination of the structure, function, and practices of the human research ethics committees (HRECs), followed by evaluation of standards for measuring research output, was conducted. Results indicate that among the HRECs, 90% followed International Council for Harmonization-Good Clinical Practice guidelines, 66.6% have been in operation for more than 5 years, 95% reviewed proposals within 8 weeks, and 56% reviewed for scientific merit apart from ethics...
April 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28419346/our-shared-vulnerability-to-dangerous-pathogens
#6
Lawrence O Gostin
The international community vastly underestimates the risk and scale of our shared vulnerability to fast moving pathogens. Ranging from SARS and novel influenzas to Ebola and Zika, the world seems to be caught off guard, despite the regularity of global health threats historically. More importantly, when governments and international institutions underestimate the threat, they also underinvest in preparedness. Failure to prepare has deep costs in human lives and economic productivity. Here, I offer a pathway to preparedness for, and rapid response to, infectious disease threats: robust and resilient national health systems; strong institutions capable of leading, particularly the World Health Organization; and investments in research and development...
April 17, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28418742/taiwan-s-public-health-national-laboratory-system-success-in-influenza-diagnosis-and-surveillance
#7
Ji-Rong Yang, Hwa-Jen Teng, Ming-Tsan Liu, Shu-Ying Li
Taiwan's National Laboratory System is one of the action packages of the Global Health Security Agenda, which was launched by the World Health Organization (WHO) to promote health security as an international priority and to encourage progress toward full implementation of the WHO International Health Regulations (IHR) 2005. The mission of each national laboratory system is to conduct real-time biosurveillance and effective laboratory-based diagnostics, as measured by a nationwide laboratory system able to reliably conduct diagnoses on specimens transported properly to designated laboratories from at least 80% of the regions in the country...
March 2017: Health Security
https://www.readbyqxmd.com/read/28418741/implementation-of-the-ihr-joint-external-evaluation-taiwan-s-experiences
#8
Yi-Chun Lo
In February 2016, the World Health Organization developed the Joint External Evaluation (JEE) tool to independently assess country capacity to prevent, detect, and respond to public health threats as part of the International Health Regulations (IHR) (2005) monitoring and evaluation framework. In light of this, the Taiwan government actively engaged at least 19 government agencies or institutions and voluntarily implemented the JEE. An External Assessment Team consisting of 6 US subject matter experts conducted the external evaluation, including site visits, from June 21 to July 1, 2016...
March 2017: Health Security
https://www.readbyqxmd.com/read/28418739/the-joint-external-evaluation-of-taiwan-the-external-evaluators-perspective
#9
Eric S Toner, Jennifer B Nuzzo, Matthew Shearer, Crystal Watson, Tara Kirk Sell, Anita Cicero
A team of experts from the Johns Hopkins Center for Health Security conducted an independent external assessment of Taiwan's capabilities under the International Health Regulations 2005 (IHR), using the IHR Joint External Evaluation (JEE) tool adopted by the World Health Organization and the Global Health Security Agenda. In this article we describe the methods and process of the assessment, identify lessons learned, and make recommendations for the government of Taiwan, the JEE process, and the JEE tool.
March 2017: Health Security
https://www.readbyqxmd.com/read/28414850/-water-resource-quality-as-related-to-economic-activity-and-health-patterns-in-sonora-mexico
#10
José Luis Manzanares Rivera
The aim of this work is to analyze the spatial distribution of potential pollution pathways of water resources given the economic activity in the Mexican border state of Sonora and propose a regional distribution in relation to cancer mortality rates across the state. The methodology is based in an exploratory and inferential data analysis using two sources of primary data: wastewater discharge concessions registered in the Public Registry on Water Rights [Registro Público de Derechos de Agua] (REPDA) and the records generated by the National Health Information System [Sistema Nacional de Información en Salud] (SINAIS) in the period 1998-2011 based on the International Classification of Disease (ICD-10)...
July 2016: Salud Colectiva
https://www.readbyqxmd.com/read/28404558/factors-associated-with-participation-in-resistance-training-a-systematic-review
#11
REVIEW
Ryan E Rhodes, David R Lubans, Nandini Karunamuni, Sarah Kennedy, Ronald Plotnikoff
OBJECTIVE: Regular participation in resistance training (RT) is critical to health and recommended in most international physical activity guidelines. Few people, however, participate in RT. The purpose of this review was to assess the demographic, behavioural, intrapersonal, interpersonal and environmental factors associated with participating in RT. DATA SOURCES: Eligible studies were from English peer-reviewed published articles that examined correlates or determinants of RT in adult samples...
April 12, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28404540/abnormal-mrna-expression-levels-of-telomere-binding-proteins-represent-biomarkers-in-myelodysplastic-syndromes-a-case-control-study
#12
Baoshan Liu, Rongdi Yan, Jie Zhang, Bin Wang, Hu Sun, Xing Cui
OBJECTIVE: As the abnormal shortening of telomeres has been shown in myelodysplastic syndromes (MDS) patients, this study was to find the relationship between the mRNA expression levels of telomere-binding proteins(TRF1/TRF2/TIN2/TPP1/POT1/RAP1) and the risk in MDS. MATERIALS AND METHODS: A total of 40 patients with MDS and 40 normal controls were selected for the study. Using telomere content assays and quantitative reverse transcription-polymerase chain reaction, we examined the mRNA levels of telomere-binding proteins TRF1/TRF2/TIN2/TPP1/POT1/RAP1 in patients with MDS...
April 13, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28403019/food-labeling-issues-in-patients-with-severe-food-allergies-solving-a-hamlet-like-doubt
#13
Vincenzo Fierro, Francesco Di Girolamo, Valeria Marzano, Lamia Dahdah, Maurizio Mennini
PURPOSE OF REVIEW: We review the laws on labeling in the international community, the difficulties they pose to the food manufacturers to prepare the food labels and the methodologies to determine the concentration of potential allergens in foods. RECENT FINDINGS: European Food Safety Authority and International Life Sciences Institute Europe are evaluating strategies to identify the threshold level of allergen that can trigger a reaction in individuals. The most used techniques to detect the presence of protein in food are Enzyme-linked immunosorbent assay, polymerase chain reaction and real time polymerase chain reaction...
April 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28389979/species-adulteration-in-the-herbal-trade-causes-consequences-and-mitigation
#14
REVIEW
Ramanujam Srirama, J U Santhosh Kumar, G S Seethapathy, Steven G Newmaster, S Ragupathy, K N Ganeshaiah, R Uma Shaanker, Gudasalamani Ravikanth
The global economy of the international trade of herbal products has been increasing by 15% annually, with the raw material for most herbal products being sourced from South and Southeast Asian countries. In India, of the 8000 species of medicinal plants harvested from the wild, approximately 960 are in the active trade. With increasing international trade in herbal medicinal products, there is also increasing concern about the widespread adulteration and species admixtures in the raw herbal trade. The adverse consequences of such species adulteration on the health and safety of consumers have only recently begun to be recognised and documented...
April 8, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28389602/shear-mediated-dilation-of-the-internal-carotid-artery-occurs-independent-of-hypercapnia
#15
Ryan L Hoiland, Kurt Jason Smith, Howard H Carter, Nia C S Lewis, Michael M Tymko, Kevin W Wildfong, Anthony R Bain, Daniel J Green, Philip N Ainslie
Evidence for shear stress as a regulator of carotid artery dilation in response to increased arterial carbon dioxide was recently demonstrated in humans during sustained elevations in CO2 (hypercapnia); however, the relative contributions of CO2 and shear stress to this response remains unclear. We examined the hypothesis that, following a 30-second transient increase in arterial CO2 tension and consequent increase in internal carotid artery shear stress, internal carotid artery diameter would increase, indicating shear-mediated dilation, in the absence of concurrent hypercapnia...
April 7, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28385607/malaria-vaccine-who-position-paper-january-2016-recommendations
#16
(no author information available yet)
This article presents the World Health Organization's (WHO) recommendations on the use of malaria vaccine excerpted from the WHO position paper on malaria vaccine published in the Weekly epidemiological Record in January 2016 [1]. The current document is the first WHO position paper on malaria vaccination and focuses primarily on the available evidence concerning the only malaria vaccine having received a positive regulation assessment from the European Medicines Agency (EMA) [2]. The position paper gives consideration to the epidemiological features of the disease and assesses the potential use of the vaccine for public health benefits...
April 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28381721/regulatory-science-in-practice-pharmaceuticals-and-medical-devices-agency
#17
Taisuke Hojo
 Review, safety, and relief services of the Pharmaceuticals and Medical Devices Agency are primarily focused on scientifically evaluating pharmaceuticals, medical devices, and cellular and tissue-based products referring to their quality, efficacy, and safety, which requires a variety of scientific knowledge and methods. Pharmaceutical regulation should be established based on the most advanced scientific expertise at all times. In order to evaluate products that use cutting-edge technology such as induced pluripotent stem cells and information and communication technology adequately, since fiscal year 2012 the Science Committee has been established as a platform to exchange opinions among members from top-ranking domestic and international academia and to enhance personnel exchanges through the Initiative to Facilitate Development of Innovative Drugs...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28379440/public-health-emergencies-of-international-concern-global-regional-and-local-responses-to-risk
#18
Belinda Bennett, Terry Carney
The declaration in 2009 that the H1N1 pandemic constituted a public health emergency of international concern (PHEIC) was the first such declaration under the revised International Health Regulations that were adopted in 2005. In the period since then PHEIC have been declared in relation to polio, Ebola, and Zika. This article evaluates initiatives that have been introduced globally, within the Asia-Pacific region, and within Australia, to strengthen preparedness for public health emergencies. Through analysis of evolving conceptualisations of risk, surveillance of zoonotic diseases, and development of public health capacities, the article argues that to date the global community has failed to make the necessary investments in health system strengthening, and that without these investments, global public health emergencies will continue to be an ongoing challenge...
March 31, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28379396/trends-in-occupational-disparities-for-exposure-to-carcinogenic-mutagenic-and-reprotoxic-chemicals-in-france-2003-10
#19
Nathalie Havet, Alexis Penot, Magali Morelle, Lionel Perrier, Barbara Charbotel, Béatrice Fervers
To explore trends in social and occupational inequalities in terms of exposure to carcinogenic, mutagenic and reprotoxic chemicals (CMR) for French employees. Our study assessed data from the French national cross-sectional survey of occupational hazards (SUMER) that was conducted in 2003 and 2010. We included all of the 27 CMR agents that were classified by the International Agency for Research on Cancer or European Union regulations as being known or presumed to have CMR potential in humans. Trends in prevalence and degree of exposure were examined using multilevel logistic regression analysis...
April 3, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28376910/the-preschool-activity-technology-health-adiposity-behaviour-and-cognition-path-abc-cohort-study-rationale-and-design
#20
Dylan P Cliff, Jade McNeill, Stewart Vella, Steven J Howard, Megan A Kelly, Douglas J Angus, Ian M Wright, Rute Santos, Marijka Batterham, Edward Melhuish, Anthony D Okely, Marc de Rosnay
BACKGROUND: Prevalence estimates internationally suggest that many preschool-aged children (3-5 years) are insufficiently physically active and engage in high levels of screen-based entertainment. Early childhood is the developmental period for which we know the least about the effects of physical activity on development and health. Likewise, rapid technological advancements in mobile electronic media have made screen-based forms of entertainment for young children ubiquitous, and research demonstrating the impacts on cognition, psychosocial well-being, and health has lagged behind the rate of adoption of these technologies...
April 4, 2017: BMC Pediatrics
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