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International health regulation

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https://www.readbyqxmd.com/read/28811841/bacteriophages-in-the-gastrointestinal-tract-and-their-implications
#1
Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Ewa Jończyk-Matysiak, Renata Wojciechowska, Andrzej Górski
The gut microbiota plays an essential role in health and disease of humans. Bacteriophages are the most abundant members of the gut virobiota and display great diversity. Phages can translocate through the mucosa to lymph and internal organs and play a role as regulators of the bacterial population in the gut. Increasing abundance of phages in the gut mucosa may reduce colonization by bacteria. Moreover, phages may have an immunomodulatory role in the immune response in the human gut. The role of phages in inflammatory bowel disease (IBD) remains unknown...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28811173/prenatal-exposure-to-pyrethroid-pesticides-and-childhood-behavior-and-executive-functioning
#2
Melissa A Furlong, Dana Boyd Barr, Mary S Wolff, Stephanie M Engel
Several previous studies of pyrethroid biomarkers and behavior have reported associations between concurrent pyrethroid levels and adverse behavioral problems in children. One geospatial study reported associations between prenatal exposure to pyrethroids and autism. However, the association between prenatal pyrethroid biomarkers and childhood behavior is unknown. The Mount Sinai Children's Environmental Health Center is a prospective birth cohort with urinary pyrethroid biomarkers during pregnancy and behavioral measurements at 4, 6, and 7-9 years of age...
August 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28807332/synthetic-biology-regulation-and-governance-lessons-from-tapic-for-the-united-states-european-union-and-singapore
#3
Benjamin D Trump
Synthetic biology is an emerging technology with potential benefits to various fields, yet also contains potential risks to human and environmental health. The field remains in an emerging state with limited quantitative guidance and a small but growing population of international researchers that conduct work within this field. Given the uncertain nature of this technology, an adaptive and anticipatory governance framework may be necessary to balance the potential benefits that may accrue from the technology's continued research alongside a desire to reduce or eliminate potential risks that may arise...
August 2, 2017: Health Policy
https://www.readbyqxmd.com/read/28806109/reflections-on-leadership-and-governance-from-the-incident-manager-of-liberia-s-ebola-response
#4
Tolbert Nyenswah
The 2014-2016 epidemic of Ebola virus disease occurred in a region with a recent history of civil war, unstable health systems, and widespread poverty. Despite these contextual challenges, the national Ebola response in Liberia controlled transmission under strong leadership that was able to rapidly coordinate activities, to manage local and international players, and to adapt upon recognizing missteps. Such leadership has persisted to improve public health capacity in post-Ebola Liberia. This article highlights the progress made toward developing a resilient health security system with capacity to prevent, detect, and respond to disease threats before they reach epidemic level...
August 14, 2017: Health Security
https://www.readbyqxmd.com/read/28805132/evaluation-of-the-decisional-fatigue-scale-among-surrogate-decision-makers-of-the-critically-ill
#5
Ronald L Hickman, Grant A Pignatiello, Sadia Tahir
Intense emotional distress and impaired information processing have been implicated in reducing a surrogate decision maker's ability to formulate informed health care decisions for a critically ill patient. The heightened intensity of negative emotions, mental effort, and impaired judgment is consistent with the manifestation of decision fatigue. The aim of this article is to describe the validity and reliability of the Decision Fatigue Scale (DFS) among surrogate decision makers of the critically ill. A convenience sample of 101 surrogate decision makers were administered the DFS and a battery of psychosocial instruments at two time points...
August 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28795830/early-predictors-of-escalating-internalizing-problems-across-middle-childhood
#6
Cen Wang, Kate E Williams, Ameneh Shahaeian, Linda J Harrison
The objective of this study is to examine the trajectory of internalizing problems across middle childhood among a population sample of Australian children, and to understand the timing of explanatory factors related to children's development of internalizing problems, by using multiple-indicator latent growth curve modeling. Participants were children, parents, and teachers in the Longitudinal Study of Australian Children (LSAC) Kindergarten (K) cohort (n = 3,153). Mothers reported on children's internalizing problems at 3 time points (6-7, 8-9, and 10-11 years)...
August 10, 2017: School Psychology Quarterly
https://www.readbyqxmd.com/read/28789646/stakeholders-views-on-the-strengths-and-weaknesses-of-maternal-care-financing-and-its-reform-in-georgia
#7
Lela Shengelia, Milena Pavlova, Wim Groot
BACKGROUND: The improvement of maternal health has been one of the aims of the health financing reforms in Georgia. Public-private relationships are the most notable part of the reform. This study aimed to assess the strengths and weakness of the maternal care financing in Georgia in terms of adequacy and effects. METHODS: A qualitative design was used to explore the opinions of key stakeholders about the adequacy of maternal care financing and financial protection of pregnant women in Georgia...
August 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28783783/yield-and-water-quality-impacts-of-field-scale-integration-of-willow-into-a-continuous-corn-rotation-system
#8
Colleen Zumpf, Herbert Ssegane, Maria Cristina Negri, Patty Campbell, Julian Cacho
Agricultural landscape design has gained recognition by the international environmental and development community as a strategy to address multiple goals in land, water, and ecosystem service management; however, field research is needed to quantify impacts on specific local environments. The production of bioenergy crops in specific landscape positions within a grain-crop field can serve the dual purpose of producing cellulosic biomass (nutrient recovery) while also providing regulating ecosystem services to improve water quality (nutrient reduction)...
July 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28780356/then-and-now-consumption-and-dependence-in-e-cigarette-users-who-formerly-smoked-cigarettes
#9
Matthew Browne, Daniel G Todd
Electronic cigarette use, or vaping, continues to be a focus for regulators and policy makers in public health, particularly since it can compete with or be a substitute for smoking. This study investigated characteristics of nicotine dependence and consumption in a sample of vapers who formerly smoked cigarettes. We recruited 436 (80% male) vapers from several internet discussion forums; 95% of whom previously smoked, but ceased after commencing vaping. These participants completed a retrospective version of the Fagerström Test for Nicotine Dependence (FTND-R), as well as a version modified to suit current vaping (FTND-V), along with measures of consumption...
July 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28774611/tic-tox-a-preliminary-discussion-on-identifying-the-forcing-agents-of-dbp-mediated-toxicity-of-disinfected-water
#10
Michael J Plewa, Elizabeth D Wagner, Susan D Richardson
The disinfection of drinking water is a major public health achievement; however, an unintended consequence of disinfection is the generation of disinfection by-products (DBPs). Many of the identified DBPs exhibit in vitro and in vivo toxicity, generate a diversity of adverse biological effects, and may be hazards to the public health and the environment. Only a few DBPs are regulated by several national and international agencies and it is not clear if these regulated DBPs are the forcing agents that drive the observed toxicity and their associated health effects...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28761937/allostatic-breakdown-of-cascading-homeostat-systems-a-computational-approach
#11
Alison Acevedo, Ioannis P Androulakis
Homeostasis posits that physiological systems compensate setpoint deviations in an attempt to maintain a state of internal constancy. Allostasis, on the other hand, suggests that physiological regulation is more appropriately described by predictive modulatory actions that, by adjusting setpoints, anticipate and react to changes in internal and external demand. In other words, "maintaining stability through change." The allostatic perspective enabled the rationalization of predictive and reactive homeostasis...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28760206/prevention-of-sudden-cardiac-death-in-the-young-developing-a-rational-reliable-and-sustainable-national-health-care-resource-a-report-from-the-cardiac-safety-research-consortium
#12
REVIEW
Salim F Idriss, Stuart Berger, Kimberly G Harmon, Allen Kindman, Robert Kleiman, Martha Lopez-Anderson, Silvana Molossi, Tess Elizabeth Saarel, Colette Strnadova, Thomas Todaro, Kaori Shinagawa, Valarie Morrow, Mitchell Krucoff, Victoria Vetter, Theressa J Wright
This White Paper, prepared by members of the Cardiac Safety Research Consortium, discusses important issues regarding sudden cardiac death in the young (SCDY), a problem that does not discriminate by gender, race, ethnicity, education, socioeconomic level, or athletic status. The occurrence of SCDY has devastating impact on families and communities. Sudden cardiac death in the young is a matter of national and international public health, and its prevention has generated deep interest from multiple stakeholders, including families who have lost children, advocacy groups, academicians, regulators, and the medical industry...
August 2017: American Heart Journal
https://www.readbyqxmd.com/read/28756294/vitamin-d-cod-liver-oil-sunshine-and-phototherapy-safe-effective-and-forgotten-tools-for-treating-and-curing-tuberculosis-infections-a-comprehensive-review
#13
REVIEW
Patrick J McCullough, Douglas S Lehrer
Tuberculosis remains an epidemic throughout the world, with over 2 billion people, or more than one third of the world's population, infected with TB. In 2015, there were an estimated 10.4 million new cases of tuberculosis, and 1.8 million deaths, making TB one of the top ten causes of death worldwide. Approximately 95% of new TB cases occur in developing countries, where the costs of treatment force many patients and their families into poverty. The United Nations and the World Health Organization are working to end this global epidemic...
July 26, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28747238/exploratory-factor-analysis-and-reliability-of-the-primary-health-care-engagement-phce-scale-in-rural-and-remote-nurses-findings-from-a-national-survey
#14
Julie G Kosteniuk, Norma J Stewart, Chandima P Karunanayake, Erin C Wilson, Kelly L Penz, Judith C Kulig, Kelley Kilpatrick, Ruth Martin-Misener, Debra G Morgan, Martha L P MacLeod
Aim The study purpose was to provide evidence of validity for the Primary Health Care Engagement (PHCE) Scale, based on exploratory factor analysis and reliability findings from a large national survey of regulated nurses residing and working in rural and remote Canadian communities. BACKGROUND: There are currently no published provider-level instruments to adequately assess delivery of community-based primary health care, relevant to ongoing primary health care (PHC) reform strategies across Canada and elsewhere...
July 27, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28745317/reticulocalbin-2-enhances-hepatocellular-carcinoma-proliferation-via-modulating-the-egfr-erk-pathway
#15
D Ding, H Huang, W Jiang, W Yu, H Zhu, J Liu, H Saiyin, J Wu, H Huang, S Jiang, L Yu
Hepatocellular carcinoma (HCC) is a major health threat worldwide. Although the involvement of reticulocalbin-2 (RCN2) in cell differentiation has been reported, its function in oncogenesis is poorly understood. Here, we showed that RCN2 was upregulated in tumors compared with adjacent non-tumorous tissues in HCC patients and RCN2 expression clinically correlated with tumor size, disease recurrence and survival rate. Both knockdown and knockout of RCN2 significantly inhibited HCC cell proliferation by inducing G1/S transition arrest and downregulating cyclin D1 expression, while the proliferative ability was restored in knockout HCC cells with exogenously expressed RCN2...
July 24, 2017: Oncogene
https://www.readbyqxmd.com/read/28744256/corticotropin-releasing-hormone-as-the-homeostatic-rheostat-of-feto-maternal-symbiosis-and-developmental-programming-in-utero-and-neonatal-life
#16
REVIEW
Viridiana Alcántara-Alonso, Pamela Panetta, Patricia de Gortari, Dimitris K Grammatopoulos
A balanced interaction between the homeostatic mechanisms of mother and the developing organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal challenges, protection from adverse programming, and safeguard maternal care availability after parturition. In the majority of pregnancies, this relationship is highly effective resulting in successful outcomes. However, in a number of pathological settings, perturbations of the maternal homeostasis disrupt this symbiosis and initiate adaptive responses with unpredictable outcomes for the fetus or even the neonate...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28743794/can-t-see-the-woods-for-the-trees-exploring-the-range-and-connection-of-tobacco-industry-argumentation-in-the-2012-uk-standardised-packaging-consultation
#17
Jessamina Lih Yan Lie, Gary Fooks, Nanne K de Vries, Suzanne M Heijndijk, Marc C Willemsen
INTRODUCTION: Transnational tobacco company (TTC) submissions to the 2012 UK standardised packaging consultation are studied to examine TTC argumentation in the context of Better Regulation practices. METHODS: A content analysis was conducted of Philip Morris International and British American Tobacco submissions to the 2012 UK consultation. Industry arguments concerning expected costs and (contested) benefits of the policy were categorised into themes and frames...
July 25, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28741235/making-patient-engagement-a-reality
#18
Daphnee S Pushparajah
Patients are increasingly recognised as the true customers of healthcare. By providing insights and perspectives, patients can help the wider healthcare community better understand their needs and ultimately enhance the value of healthcare solutions being developed. In the development of new medicines, for example, meaningful patient engagement can enable the pharmaceutical industry, healthcare providers and other stakeholders to achieve more meaningful health outcomes. While both the pharmaceutical industry and regulators have achieved some progress in incorporating patient perspectives into their activities, the lack of standardised best practices and metrics has made it challenging to achieve consistency and measure success in patient engagement...
July 24, 2017: Patient
https://www.readbyqxmd.com/read/28739640/egcg-ameliorates-high-fat-and-high-fructose-induced-cognitive-defects-by-regulating-the-irs-akt-and-erk-creb-bdnf
#19
Yashi Mi, Guoyuan Qi, Rong Fan, Qinglian Qiao, Yali Sun, Yuqi Gao, Xuebo Liu
Obesity, which is caused by an energy imbalance between calorie intake and consumption, has become a major international health burden. Obesity increases the risk of insulin resistance and age-related cognitive decline, accompanied by peripheral inflammation. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, possesses antioxidant, anti-inflammatory, and cardioprotective activities; however, few reports have focused on its potential effect on cognitive disorders. In this study, our goal was to investigate the protective effects of EGCG treatment on insulin resistance and memory impairment induced by a high-fat and high-fructose diet (HFFD)...
July 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28737661/toward-establishing-core-outcome-domains-for-trials-in-kidney-transplantation-report-of-the-standardized-outcomes-in-nephrology-kidney-transplantation-consensus-workshops
#20
Allison Tong, John Gill, Klemens Budde, Lorna Marson, Peter P Reese, David Rosenbloom, Lionel Rostaing, Germaine Wong, Michelle A Josephson, Timothy L Pruett, Anthony N Warrens, Jonathan C Craig, Benedicte Sautenet, Nicole Evangelidis, Angelique F Ralph, Camilla S Hanson, Jenny I Shen, Kirsten Howard, Klemens Meyer, Ronald D Perrone, Daniel E Weiner, Samuel Fung, Maggie K M Ma, Caren Rose, Jessica Ryan, Ling-Xin Chen, Martin Howell, Nicholas Larkins, Siah Kim, Sobhana Thangaraju, Angela Ju, Jeremy R Chapman
BACKGROUND: Treatment decisions in kidney transplantation requires patients and clinicians to weigh the benefits and harms of a broad range of medical and surgical interventions, but the heterogeneity and lack of patient-relevant outcomes across trials in transplantation makes these trade-offs uncertain, thus, the need for a core outcome set that reflects stakeholder priorities. METHODS: We convened 2 international Standardized Outcomes in Nephrology-Kidney Transplantation stakeholder consensus workshops in Boston (17 patients/caregivers; 52 health professionals) and Hong Kong (10 patients/caregivers; 45 health professionals)...
August 2017: Transplantation
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