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https://www.readbyqxmd.com/read/27933543/integrative-analysis-of-genetic-genomic-and-phenotypic-data-for-ethanol-behaviors-a-network-based-pipeline-for-identifying-mechanisms-and-potential-drug-targets
#1
James W Bogenpohl, Kristin M Mignogna, Maren L Smith, Michael F Miles
Complex behavioral traits, such as alcohol abuse, are caused by an interplay of genetic and environmental factors, producing deleterious functional adaptations in the central nervous system. The long-term behavioral consequences of such changes are of substantial cost to both the individual and society. Substantial progress has been made in the last two decades in understanding elements of brain mechanisms underlying responses to ethanol in animal models and risk factors for alcohol use disorder (AUD) in humans...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933383/the-burden-of-rotator-cuff-surgery-in-italy-a-nationwide-registry-study
#2
Umile Giuseppe Longo, Giuseppe Salvatore, Giacomo Rizzello, Alessandra Berton, Mauro Ciuffreda, Vincenzo Candela, Vincenzo Denaro
PURPOSE: This study aimed to estimate the yearly number of RC surgeries in Italy, a country with universal access to healthcare for its population, from 2001 to 2014, based on official information source as hospitalization records. A secondary aim was to explore geographical variation in equity in access to RC surgery between three macroregions of Italy (North, Center and South). A tertiary aim was to perform statistical projections of the number of RC procedure volumes and rates on the basis of data from 2001 to 2014...
December 8, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27932526/human-plasma-n-glycosylation-as-analyzed-by-maldi-fticr-ms-associates-with-markers-of-inflammation-and-metabolic-health
#3
Karli R Reiding, L Renee Ruhaak, Hae-Won Uh, Said El Bouhaddani, Erik B van den Akker, Rosina Plomp, Liam A McDonnell, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Marian Beekman, Manfred Wuhrer
Glycosylation is an abundant co- and post-translational protein modification of importance to protein processing and activity. While not template-defined, glycosylation does reflect the biological state of an organism and is a high-potential biomarker for disease and patient stratification. However, to interpret a complex but informative sample like the total plasma N-glycome (TPNG), it is important to establish its baseline association with plasma protein levels and systemic processes. Thus far, large scale studies (n > 200) of the TPNG have been performed with methods of chromatographic and electrophoretic separation, which, while being informative, are limited in resolving the structural complexity of plasma N-glycans...
December 8, 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27932442/contraceptive-sales-in-the-setting-of-the-zika-virus-epidemic
#4
Luis Bahamondes, Moazzam Ali, Ilza Monteiro, Arlete Fernandes
STUDY QUESTION: Has there been any influence of the Zika virus (ZIKV) outbreak on the sales of contraceptive methods in Brazil? SUMMARY ANSWER: Contraceptive sales in the 24 months of evaluation showed little variation and no significant change has been observed since the ZIKV outbreak. WHAT IS KNOWN ALREADY: Transmission of ZIKV is primarily by Aedes aegypti mosquitoes; however, sexual transmission has also been described. The association of several birth defects and the ZIKV infection during pregnancy has been established, and it was estimated in Bahia, Brazil that the infection rate could range from 10% to 80%...
December 7, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27932344/using-robust-normative-data-to-investigate-the-neuropsychology-of-cognitive-aging
#5
Karra D Harrington, Yen Ying Lim, David Ames, Jason Hassenstab, Stephanie Rainey-Smith, Joanne Robertson, Olivier Salvado, Colin L Masters, Paul Maruff
OBJECTIVE: The extent to which increasing age is associated with impairment in cognitive function, termed cognitive aging, may have been overestimated in prior studies. The inclusion of individuals with severe or uncontrolled systemic medical illness or prodromal neurodegenerative disease in normal aging samples is likely to bias estimates toward lower cognitive performance and inflate estimates of variability. METHOD: Unbiased estimates of cognitive aging in 658 adults aged 60-84, who underwent rigorous screening to ensure their general and cognitive health, were computed...
December 8, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27932343/influence-of-the-day-care-home-and-neighbourhood-environment-on-young-children-s-physical-activity-and-health-protocol-for-the-playce-observational-study
#6
Hayley Christian, Clover Maitland, Stephanie Enkel, Georgina Trapp, Stewart G Trost, Jasper Schipperijn, Bryan Boruff, Leanne Lester, Michael Rosenberg, Stephen R Zubrick
INTRODUCTION: The early years are a critical period in a child's health and development, yet most preschool children fail to meet physical activity guidelines. Outside of the home and neighbourhood, children spend a large proportion of time within early childhood education and care (ECEC) services such as long day care. Research is required to determine how the design of day care outdoor (and indoor) spaces provides opportunities or constraints for physical activity. A significant evidence gap surrounds what objectively measured attributes of the home and neighbourhood environment influence preschoolers' physical activity...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932340/is-walk-score-associated-with-hospital-admissions-from-chronic-diseases-evidence-from-a-cross-sectional-study-in-a-high-socioeconomic-status-australian-city-state
#7
Soumya Mazumdar, Vincent Learnihan, Thomas Cochrane, Hai Phung, Bridget O'Connor, Rachel Davey
OBJECTIVES: To explore patterns of non-communicable diseases (NCDs) in the Australian Capital Territory (ACT).To ascertain the effect of the neighbourhood built environmental features and especially walkability on health outcomes, specifically for hospital admissions from NCDs. DESIGN: A cross-sectional analysis of public hospital episode data (2007-2013). SETTING: Hospitalisations from the ACT, Australia at very small geographic areas. PARTICIPANTS: Secondary data on 75 290 unique hospital episodes representing 39 851 patients who were admitted to ACT hospitals from 2007 to 2013...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932222/using-a-contextualized-sensemaking-model-for-interaction-design-a-case-study-of-tumor-contouring
#8
Anet Aselmaa, Marcel van Herk, Anne Laprie, Ursula Nestle, Irina Götz, Nicole Wiedenmann, Tanja Schimek-Jasch, Francois Picaud, Charlotte Syrykh, Leonel V Cagetti, Maria Jolnerovski, Yu Song, Richard H M Goossens
Sensemaking theories help designers understand the cognitive processes of a user when he/she performs a complicated task. This paper introduces a two-step approach of incorporating sensemaking support within the design of health information systems by: 1) modeling the sensemaking process of physicians while performing a task, and 2) identifying software interaction design requirements that support sensemaking based on this model. The two-step approach is presented based on a case study of the tumor contouring clinical task for radiotherapy planning...
December 5, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27931984/knowledge-about-sources-of-dietary-fibres-and-health-effects-using-a-validated-scale-a-cross-country-study
#9
R P F Guiné, J Duarte, M Ferreira, P Correia, M Leal, I Rumbak, I C Barić, D Komes, Z Satalić, M M Sarić, M Tarcea, Z Fazakas, D Jovanoska, D Vanevski, E Vittadini, N Pellegrini, V Szűcs, J Harangozó, A El-Kenawy, O El-Shenawy, E Yalçın, C Kösemeci, D Klava, E Straumite
OBJECTIVES: Dietary fibre (DF) is one of the components of diet that strongly contributes to health improvements, particularly on the gastrointestinal system. Hence, this work intended to evaluate the relations between some sociodemographic variables such as age, gender, level of education, living environment or country on the levels of knowledge about dietary fibre (KADF), its sources and its effects on human health, using a validated scale. STUDY DESIGN: The present study was a cross-sectional study...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931796/the-alzheimer-s-disease-neuroimaging-initiative-3-continued-innovation-for-clinical-trial-improvement
#10
REVIEW
Michael W Weiner, Dallas P Veitch, Paul S Aisen, Laurel A Beckett, Nigel J Cairns, Robert C Green, Danielle Harvey, Clifford R Jack, William Jagust, John C Morris, Ronald C Petersen, Jennifer Salazar, Andrew J Saykin, Leslie M Shaw, Arthur W Toga, John Q Trojanowski
INTRODUCTION: The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI-3, which began on August 1, 2016, is a 5-year renewal of the current ADNI-2 study. METHODS: ADNI-3 will follow current and additional subjects with normal cognition, mild cognitive impairment, and AD using innovative technologies such as tau imaging, magnetic resonance imaging sequences for connectivity analyses, and a highly automated immunoassay platform and mass spectroscopy approach for cerebrospinal fluid biomarker analysis...
December 5, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27931698/the-effectiveness-of-nurse-led-preoperative-assessment-clinics-for-patients-receiving-elective-orthopaedic-surgery-a-systematic-review
#11
Chan Sau-Man Conny, Ip Wan-Yim
PURPOSE: Nurse-led preoperative assessment clinics (POAC) have been introduced in different specialty areas to assess and prepare patients preoperatively in order to avoid last-minute surgery cancellations. Not all patients are referred to POACs before surgery, and the benefits of nurse-led POACs are not well documented in Hong Kong. The purpose of this systemic review was to identify the best available research evidence to inform current clinical practice, guide health care decision making and promote better care...
December 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27931566/barriers-to-organ-transplantation-in-the-algerian-health-system-from-the-perspective-of-health-professionals-a-qualitative-approach
#12
N Laidouni, D Gil-González, S Latorre-Arteaga
BACKGROUND: Organ transplantation is often the only treatment for end-stage organ failure and is considered to be a cost-effective intervention with high impact on the health and quality of life of patients with chronic illnesses. Algeria has low rates of organ donation and transplantation, and health system coverage is not sufficient for the large number of patients awaiting this type of treatment. Physicians' perspectives about the health system are essential to understanding the obstacles present in the development of transplant services...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931219/influences-on-teleconsultation-project-utilization-rates-the-role-of-dominant-logic
#13
David L Paul, Reuben R McDaniel
BACKGROUND: This research analyzes teleconsultation from both a mechanistic and complex adaptive system (CAS) dominant logic in order to further understand the influence of dominant logic on utilization rates of teleconsultation projects. In both dominant logics, the objective of teleconsultation projects is to increase access to and quality of healthcare delivery in a cost efficient manner. A mechanistic dominant logic perceives teleconsultation as closely resembling the traditional service delivery model, while a CAS dominant logic focuses on the system's emergent behavior of learning resulting from the relationships and interactions of participating healthcare providers...
December 8, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27931204/web-based-infectious-disease-surveillance-systems-and-public-health-perspectives-a-systematic-review
#14
Jihye Choi, Youngtae Cho, Eunyoung Shim, Hyekyung Woo
BACKGROUND: Emerging and re-emerging infectious diseases are a significant public health concern, and early detection and immediate response is crucial for disease control. These challenges have led to the need for new approaches and technologies to reinforce the capacity of traditional surveillance systems for detecting emerging infectious diseases. In the last few years, the availability of novel web-based data sources has contributed substantially to infectious disease surveillance...
December 8, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27930668/oral-cholera-vaccination-delivery-cost-in-low-and-middle-income-countries-an-analysis-based-on-systematic-review
#15
Vittal Mogasale, Enusa Ramani, Hyeseung Wee, Jerome H Kim
BACKGROUND: Use of the oral cholera vaccine (OCV) is a vital short-term strategy to control cholera in endemic areas with poor water and sanitation infrastructure. Identifying, estimating, and categorizing the delivery costs of OCV campaigns are useful in analyzing cost-effectiveness, understanding vaccine affordability, and in planning and decision making by program managers and policy makers. OBJECTIVES: To review and re-estimate oral cholera vaccination program costs and propose a new standardized categorization that can help in collation, analysis, and comparison of delivery costs across countries...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27930610/using-mhealth-for-hiv-tb-treatment-support-in-lesotho-enhancing-patient-provider-communication-in-the-start-study
#16
Yael Hirsch-Moverman, Amrita Daftary, Katharine A Yuengling, Suzue Saito, Moeketsi Ntoane, Koen Frederix, Llang B Maama, Andrea A Howard
BACKGROUND: mHealth is a promising means of supporting adherence to treatment. The Start TB patients on ART and Retain on Treatment (START) study included real-time adherence support using short-text messaging service (SMS) text messaging and trained village health workers (VHWs). We describe the use and acceptability of mHealth by patients with HIV/tuberculosis and health care providers. METHODS: Patients and treatment supporters received automated, coded medication and appointment reminders at their preferred time and frequency, using their own phones, and $3...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930280/development-of-electronic-medical-record-based-rounds-report-results-in-improved-resident-efficiency-more-time-for-direct-patient-care-and-education-and-less-resident-duty-hour-violations
#17
Phillip B Ham, Toby Anderton, Ryan Gallaher, Mike Hyrman, Erika Simmerman, Annamalai Ramanathan, David Fallaw, Steven Holsten, Charles Gordon Howell
Surgeons frequently report frustration and loss of efficiency with electronic medical record (EMR) systems. Together, surgery residents and a programmer at Augusta University created a rounds report (RR) summarizing 24 hours of vitals, intake/output, labs, and other values for each inpatient that were previously transcribed by hand. The objective of this study was to evaluate the RRs effect on surgery residents. Surgery residents were queried to assess the RRs impact. Outcome measures were time spent preparing for rounds, direct patient care time, educational activity time, rates of incorrect/incomplete data on rounds, and rate of duty hour violations...
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27928753/comparison-of-in-vitro-test-systems-using-bacterial-and-mammalian-cells-for-genotoxicity-assessment-within-the-health-related-indication-value-hriv-concept
#18
Prantl Eva-Maria, Kramer Meike, K Schmidt Carsten, Knauer Martina, Gartiser Stefan, Shuliakevich Aliaksandra, Milas Julia, Glatt Hansruedi, Meinl Walter, Hollert Henner
In numerous cases, the German health-related indication value (HRIV) concept has proved its practicability for the assessment of drinking water relevant trace substances (Umweltbundesamt 2003). The HRIV is based on the toxicological profile of a substance. An open point of the HRIV concept has been the assignment of standardized test procedures to be used for the assessment. The level of the HRIV is at its lowest as soon as the genotoxicity of the substance is detected. As a single test on its own, it is not sufficient enough to assess the human toxicological relevance of a genotoxic effect or exclude it in the case of a negative result; a reasonable test battery was required, technically oriented towards the already harmonized international, hierarchical evaluation for toxicological assessment of chemicals...
December 8, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27928726/evaluating-the-safety-profile-of-non-active-implantable-medical-devices-compared-with-medicines
#19
REVIEW
Josep Pane, Preciosa M Coloma, Katia M C Verhamme, Miriam C J M Sturkenboom, Irene Rebollo
Recent safety issues involving non-active implantable medical devices (NAIMDs) have highlighted the need for better pre-market and post-market evaluation. Some stakeholders have argued that certain features of medicine safety evaluation should also be applied to medical devices. Our objectives were to compare the current processes and methodologies for the assessment of NAIMD safety profiles with those for medicines, identify potential gaps, and make recommendations for the adoption of new methodologies for the ongoing benefit-risk monitoring of these devices throughout their entire life cycle...
December 7, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27928542/integration-of-health-information-systems-to-promote-health
#20
Leila Shahmoradi, Mahdi Habibi-Koolaee
No abstract text is available yet for this article.
August 2016: Iranian Journal of Public Health
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