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https://www.readbyqxmd.com/read/27888061/secretory-function-of-ovarian-cells-and-myometrial-contractions-in-cow-are-affected-by-chlorinated-insecticides-chlordane-heptachlor-mirex-in-vitro
#1
Michael Hubert Wrobel, Jaroslaw Mlynarczuk
The aim of the study was to investigate the effect of chlordane, heptachlor and mirex, on hormonal regulation of the force of myometrial contractions. Myometrial, endometrial, granulosa and luteal cells as well as strips of myometrium from non-pregnant cows were incubated with three insecticides at environmentally relevant doses (0.1, 1 or 10ng/ml). None of the insecticides affected the viability of studied cells. Chlordane stimulated, while heptachlor and mirex inhibited, secretion of testosterone and estradiol from granulosa cells as well as secretion of progesterone from luteal cells, respectively...
November 22, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27884789/surgery-for-advanced-epithelial-ovarian-cancer
#2
REVIEW
Neville F Hacker, Archana Rao
Cytoreductive surgery for patients with advanced epithelial ovarian cancer has been practised since the pioneering work of Tom Griffiths in 1975. Further research has demonstrated the prognostic significance of the extent of metastatic disease pre-operatively, and of complete cytoreduction post-operatively. Patients with advanced epithelial ovarian cancer should be referred to high volume cancer units, and managed by multidisciplinary teams. The role of thoracoscopy and resection of intrathoracic disease is presently investigational...
October 20, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27866379/effects-of-oral-exposure-to-the-phthalate-substitute-acetyl-tributyl-citrate-on-female-reproduction-in-mice
#3
Lindsay M Rasmussen, Nivedita Sen, Xiaosong Liu, Zelieann R Craig
Acetyl tributyl citrate (ATBC), is a phthalate substitute used in food and medical plastics, cosmetics and toys. Although systemically safe up to 1000 mg kg(-1)  day(-1) , its ability to cause reproductive toxicity in females at levels below 50 mg kg(-1)  day(-1) has not been examined. This study evaluated the effects of lower ATBC exposures on female reproduction using mice. Adult CD-1 females (n = 7-8 per treatment) were dosed orally with tocopherol-stripped corn oil (vehicle), 5 or 10 mg kg(-1)  day(-1) ATBC daily for 15 days, and then bred with a proven breeder male...
November 20, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27836207/primary-debulking-surgery-of-the-upper-abdomen-and-the-diaphragm-with-a-plasma-device-surgery-system-for-advanced-ovarian-cancer
#4
Gloria Cordeiro Vidal, Guillaume Babin, Denis Querleu, Frédéric Guyon
OBJECTIVE: Electrically neutral argon plasma (PlasmaJet™) technology is a surgical option that helps to get an aggressive cytoreduction in selected patients with ovarian cancer because it can be directly applied by the surgeon to treat the tissue surface [1,2]. Upper abdominal surgical procedures are an important part of the surgery in these patients [3], there is a 22% complications rate when they are performed [4]. We present a surgical approach to ovarian cancer debulking using PlasmaJet™...
November 8, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27649578/aspiration-of-immature-oocytes-during-cesarean-section-for-fertility-preservation
#5
Avi Ben-Haroush, Ronit Abir, Onit Sapir, Roni Garor, Benjamin Fisch
BACKGROUND: In vitro maturation of immature oocytes is an important technology for selected clinical indications. We previously described a pregnant woman with a history of renal transplantation who underwent oocyte aspiration during cesarean section (CS) for fertility preservation and future surrogacy. CASE: A 27-year-old pregnant woman was diagnosed with neck rhabdomyosarcoma at 37 weeks' gestation. CS was performed with direct aspiration of small follicles from one ovary and oophorectomy of the other...
September 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27630317/diaphragmatic-surgery-in-advanced-ovarian-tubal-and-peritoneal-cancer-a-7-year-retrospective-analysis-of-the-tumor-bank-ovarian-cancer-network
#6
Mustafa Zelal Muallem, Jumana Almuheimid, Rolf Richter, Elena Ioana Braicu, Suzan Osman, Jalid Sehouli
AIM: This study aimed to analyze diaphragmatic interventions and their complications in primary cytoreductive surgery (PCS) and to study their impact on attaining complete tumor resection (CTR) in advanced ovarian cancer (AOC), which is purportedly reflected in better disease-free and overall survival. PATIENTS AND METHODS: The study's collective consisted of 536 consecutive patients presenting a first diagnosis of AOC who underwent PCS between 2007 and 2013 at the Charité Medical University, Berlin...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27542707/recurrent-massive-ascites-due-to-mossy-endometriosis
#7
Erica C Dun, Serena Wong, Nisha A Lakhi, Ceana H Nehzat
OBJECTIVE: To report the medical and surgical management of a rare case of recurrent moss-like endometriosis and associated hemorrhagic ascites. DESIGN: Video description of the case, demonstration of the surgical technique, discussion of the histology, and review of endometriosis-associated ascites. SETTING: Tertiary referral center. PATIENT(S): A 26-year-old nulliparous woman of Nigerian heritage with recurrent hemorrhagic ascites due to endometriosis...
August 16, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27488214/current-south-african-clinical-practice-in-debulking-surgery-for-ovarian-cancer
#8
Jana Billson, F Haynes van der Merwe, Robbert P Soeters
INTRODUCTION: The aim of this study was to assess practice patterns and rationale with regard to debulking surgery for advanced epithelial ovarian carcinoma among South African Gynaecological oncologists. METHODS: A survey was distributed to all practicing gynecological oncologists in South Africa. It was structured to assess definitions of optimal debulking, procedures used to achieve optimal debulking, and reasons for not performing specific procedures. Respondents were also asked to report on experience and additional surgical training to improve skill in performing ultra-radical debulking surgery...
October 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27436368/which-should-be-the-preferred-technique-during-laparoscopic-ovarian-cystectomy-hemostatic-sutures-or-bipolar-electrocoagulation-a-randomized-controlled-prospective-study-of-long-term-ovarian-reserve
#9
Cagdas Sahin, Ali Akdemir, Ahmet Mete Ergenoglu, Banu Ozgurel, Ahmet Ozgur Yeniel, Dilek Taskiran, Fatih Sendag
The aim of the present study was to determine the long-term effects of different laparoscopic hemostatic techniques on ovarian reserve after ovarian cystectomy. Ninety patients with unilateral ovarian cysts were recruited and randomly distributed into 2 groups. Laparoscopic stripping cystectomy was performed in all patients. Afterward, cystectomy hemostasis was achieved via hemostatic suture or bipolar electrocoagulation. Serum levels of anti-Müllerian hormone (AMH) were determined preoperatively and postoperatively at 1, 3, and 12 months, and patients were evaluated for residual ovarian volume, antral follicle count, and pregnancy...
July 19, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27428495/pelvic-congestion-syndrome-and-left-renal-compression-syndrome-clinical-features-and-therapeutic-approaches
#10
REVIEW
Christina Jeanneret, Konstantin Beier, Alexander von Weymarn, Jürg Traber
Knowledge of the anatomy of the pelvic, gonadal and renal veins is important to understand pelvic congestion syndrome (PCS) and left renal vein compression syndrome (LRCS), which is also known as the nutcracker syndrome. LRCS is related to PCS and to the presence of vulvar, vaginal and pudendal varicose veins. The diagnosis of the two syndromes is difficult, and usually achieved with CT- or phlebography. The gold standard is the intravenous pressure measurement using conventional phlebography. The definition of PCS is described as pelvic pain, aggravated in the standing position and lasting for more than 6 months...
2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27054965/fertility-outcome-after-laparoscopic-treatment-of-advanced-endometriosis-in-two-groups-of-infertile-patients-with-and-without-ovarian-endometrioma
#11
Adel Shervin, Arash Mohazzab, Mina Aminlou, Koorosh Kamali, Roya Padmehr, Khadijeh Shadjoo, Parvin Jaberi-Pour, Elham Akbari
OBJECTIVE: To evaluate the result of laparoscopic endometrioma excision in fertility outcome of advanced endometriosis patients. STUDY DESIGN: The study was designated as historical cohort, in a private referral center of advance laparoscopy. 111 infertile patients, diagnosed as endometriosis, were divided in two groups: DIE (deep infiltrative endometriosis) and endometrioma (case group), and patients with only DIE (without endometrioma ((control group). All patients underwent global laparoscopic resection of DIE lesion (both groups) and laparoscopic excisional cystectomy of endometrioma (case groups)...
June 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27040418/maximal-effort-cytoreductive-surgery-for-disseminated-ovarian-cancer-in-a-uk-setting-challenges-and-possibilities
#12
Christina Fotopoulou, Benjamin P Jones, Konstantinos Savvatis, Jeremy Campbell, Maria Kyrgiou, Alan Farthing, Stephen Brett, Rene Roux, Marcia Hall, Gordon Rustin, Hani Gabra, Long Jiao, Richard Stümpfle
OBJECTIVE: To assess surgical morbidity and mortality of maximal effort cytoreductive surgery for disseminated epithelial ovarian cancer (EOC) in a UK tertiary center. METHODS/MATERIALS: A monocentric prospective analysis of surgical morbidity and mortality was performed for all consecutive EOC patients who underwent extensive cytoreductive surgery between 01/2013 and 12/2014. Surgical complexity was assessed by the Mayo clinic surgical complexity score (SCS). Only patients with high SCS ≥5 were included in the analysis...
September 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/26979065/heterotopic-ovarian-transplantation-results-in-less-apoptosis-than-orthotopic-transplantation-in-a-minipig-model
#13
Lia Cruz V C Damásio, José Maria Soares-Júnior, Jairo Iavelberg, Gustavo A R Maciel, Manuel de Jesus Simões, Ricardo Dos Santos Simões, Eduardo Vieira da Motta, Maria Cândida Pinheiro Baracat, Edmund C Baracat
BACKGROUND: Ovarian autotransplantation has shown increasing promise as a clinical method for the preservation of fertility and hormonal function. However, information regarding the success rate of this type of transplantation is limited. We hypothesized that results vary according to the site of the ovarian transplantation. To test this hypothesis, fresh or cryopreserved ovarian strips were autotransplanted to orthotopic or heterotopic sites. The strips were later collected, and the morphology and expression of selected markers of apoptosis were evaluated...
2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/26969445/the-effect-of-fsh-and-activin-a-on-akt-and-mapk1-3-phosphorylation-in-cultured-bovine-ovarian-cortical-strips
#14
Filiz Tepekoy, Gokhan Akkoyunlu
BACKGROUND: rhFSH and rhActA have been used in mammalian ovarian follicle culture systems for activation of follicular growth in vitro and suggested to be responsible for primordial follicle survival through MAPK and Akt pathways. The aim of our study was to determine the effects of rhFSH and rhActA on Akt, pAkt, MAPK1/3 and pMAPK1/3 protein levels in bovine ovarian cortical strips cultured in vitro. METHODS: Ovarian cortical strips from heifers were cultured in the presence of rhFSH (50 ng/mL), rhActA (100 ng/mL) or combination of these factors for 6 days...
2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/26949139/morphometrical-analysis-of-preantral-follicular-survival-of-vegf-treated-bovine-ovarian-cortex-tissue-following-xenotransplantation-in-an-immune-deficient-mouse-model
#15
A Langbeen, C Van Ginneken, E Fransen, E Bosmans, J L M R Leroy, P E J Bols
The increasing number of cancer survivors the past decades, has sparked the need for fertility preservation strategies. Due to predominantly ethical constraints, human research material is scarce. A bovine in vitro model is a valuable alternative. Therefore, the following objectives were defined: 1) to xeno-graft bovine ovarian cortex tissue in immune deficient mice as a study-model for female fertility preservation strategies; 2) to stereologically quantify vascularization in Vascular Endothelial Growth Factor (VEGF)-treated and non-treated tissue; 3) to study preantral follicular survival in situ, after xenotransplantation...
May 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/26902858/successful-slush-nitrogen-vitrification-of-human-ovarian-tissue
#16
Riccardo Talevi, Vincenza Barbato, Ilaria Fiorentino, Sabrina Braun, Cristofaro De Stefano, Raffaele Ferraro, Sam Sudhakaran, Roberto Gualtieri
OBJECTIVE: To study whether slush nitrogen vitrification improves the preservation of human ovarian tissue. DESIGN: Control vs. treatment study. SETTING: University research laboratory. PATIENT(S): Ovarian biopsies collected from nine women (aged 14-35 years) during laparoscopic surgery for benign gynecologic conditions. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Ovarian cortical strips of 2 × 5 × 1 mm were vitrified with liquid or slush nitrogen...
June 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26850447/impact-of-laparoscopic-cystectomy-of-endometriotic-and-non-endometriotic-cysts-on-ovarian-volume-antral-follicle-count-afc-and-ovarian-doppler-velocimetry
#17
Angelo Cagnacci, Manuela Bellafronte, Anjeza Xholli, Federica Palma, Maria Maddalena Carbone, Costantino Di Carlo, Giovanni Grandi
OBJECTIVE: To evaluate the effect on ovarian reserve and blood flow of unilateral laparoscopic stripping of endometriotic versus non-endometriotic cysts. DESIGN: Prospective observational study. SETTING: Tertiary university gynecology unit. PATIENTS: During the study period, 71 subjects underwent the first laparoscopic surgery for removal of a monolateral benign ovarian cyst. INTERVENTIONS: Trans-vaginal ultrasound scans of the pelvis about six months after surgery...
2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26682578/comparison-between-the-stripping-technique-and-the-combined-excisional-ablative-technique-for-the-treatment-of-bilateral-ovarian-endometriomas-a-multicentre-rct
#18
Ludovico Muzii, Chiara Achilli, Valentino Bergamini, Massimo Candiani, Elisabetta Garavaglia, Lucia Lazzeri, Francesca Lecce, Antonio Maiorana, Francesco Maneschi, Riccardo Marana, Alessio Perandini, Maria Grazia Porpora, Renato Seracchioli, Emanuela Spagnolo, Michele Vignali, Pierluigi Benedetti Panici
STUDY QUESTION: Is the combined excisional/ablative technique for the treatment of ovarian endometriomas better than the traditional stripping technique in terms of recurrence rate? SUMMARY ANSWER: There is no evidence that the combined excisional/ablative technique is better than the traditional stripping technique, as similar recurrence rates were observed for the two techniques. WHAT IS KNOWN ALREADY: The stripping technique is associated with better results compared with ablative, non-excisional techniques for the treatment of ovarian endometriomas...
February 2016: Human Reproduction
https://www.readbyqxmd.com/read/26681374/prediction-of-normal-ovulation-by-sonographic-folliculometry-involving-natural-cycles-among-women-in-ojo-southwest-nigeria
#19
C U Eze, H C Ugwu, C U Eze, K Ochie, I U Nwadike, C Otika
AIM: Accurate prediction of ovulation is important in the management of female infertility. The aim of this study was to determine the sonographic sensitivity of reduction in follicular size and disappearance of ovarian follicle as predictors of imminent ovulation. METHODS: This was a longitudinal study involving 100 women between the ages of 18 and 35 years. Transvaginal sonography with 6.5 MHz probe frequency was performed with a General Electric (RT 2800) ultrasound machine...
May 13, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/26644859/follicle-development-of-xenotransplanted-sheep-ovarian-tissue-into-male-and-female-immunodeficient-rats
#20
Leila Sadat Tahaei, Hussein Eimani, Ghazaleh Hajmusa, Rouhollah Fathi, Mojtaba Rezazadeh Valojerdi, Abdolhossein Shahverdi, Poopak Eftekhari-Yazdi
BACKGROUND: This study aimed to assess follicle survival after xenotransplantation of sheep ovarian tissue into male and female immunodeficient rats. We evaluated the effects of gonadotropin treatment on follicular development in the transplanted tissue. MATERIALS AND METHODS: In this experimental study, sheep ovarian cortical strips were transplanted into the neck back muscles of 8 male and 8 female immunodeficient, castrated rats. Fourteen days after surgery, each rat was treated with human menopausal gonadotropin (hMG) for 9 weeks...
October 2015: International Journal of Fertility & Sterility
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