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https://www.readbyqxmd.com/read/28340238/cigarette-smoke-exposure-worsens-endotoxin-induced-lung-injury-and-pulmonary-edema-in-mice
#1
Jeffrey E Gotts, Jason Abbott, Xiaohui Fang, Haru Yanagisawa, Naoki Takasaka, Stephen L Nishimura, Carolyn S Calfee, Michael A Matthay
Introduction: Cigarette smoking (CS) remains a major public health concern and has recently been associated with an increased risk of developing acute respiratory distress syndrome (ARDS). Bronchoalveolar lavage (BAL) experiments in human volunteers have demonstrated that active smokers develop increased alveolar-epithelial barrier permeability to protein after inhaling lipopolysaccharide (LPS). Here we tested the hypothesis that short-term whole-body CS exposure would increase LPS-induced lung edema in mice...
March 9, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28340086/real-world-massage-therapy-produces-meaningful-effectiveness-signal-for-primary-care-patients-with-chronic-low-back-pain-results-of-a-repeated-measures-cohort-study
#2
William G Elder, Niki Munk, Margaret M Love, Geza G Bruckner, Kathryn E Stewart, Kevin Pearce
Objective.:  While efficacy of massage and other nonpharmacological treatments for chronic low back pain is established, stakeholders have called for pragmatic studies of effectiveness in "real-world" primary health care. The Kentucky Pain Research and Outcomes Study evaluated massage impact on pain, disability, and health-related quality of life for primary care patients with chronic low back pain. We report effectiveness and feasibility results, and make comparisons with established minimal clinically important differences...
March 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28337897/exhaled-breath-temperature-measurement-influence-of-circadian-rhythm
#3
G E Carpagnano, D Lacedonia, M Malerba, D Martinelli, G Cotugno, M P Foschino-Barbaro
Exhaled breath temperature (EBT) is an expression of airway inflammation, an event that drives several lung diseases. The measurement of the exhaled breath temperature has recently been proposed as a popular tool in the diagnosis and monitoring of inflammatory lung diseases due to the fact that it is a non-invasive method. The influence of external factors on EBT, its reproducibility, and its sensitivity to treatment have already been explored. However, to reach clinical practice, EBT requires a complete validation that is still lacking...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337460/caudal-epidural-block-an-updated-review-of-anatomy-and-techniques
#4
REVIEW
Sheng-Chin Kao, Chia-Shiang Lin
Caudal epidural block is a commonly used technique for surgical anesthesia in children and chronic pain management in adults. It is performed by inserting a needle through the sacral hiatus to gain entrance into the sacral epidural space. Using conventional blind technique, the failure rate of caudal epidural block in adults is high even in experienced hands. This high failure rate could be attributed to anatomic variations that make locating sacral hiatus difficult. With the advent of fluoroscopy and ultrasound in guiding needle placement, the success rate of caudal epidural block has been markedly improved...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28336316/effects-of-age-and-soybean-isoflavones-on-hepatic-cholesterol-metabolism-and-thyroid-hormone-availability-in-acyclic-female-rats
#5
Branka Šošić-Jurjević, Dieter Lütjohann, Ivana Jarić, Marko Miler, Danijela Vojnović Milutinović, Branko Filipović, Vladimir Ajdžanović, Kostja Renko, Eva Katrin Wirth, Snežana Janković, Josef Kӧhrle, Verica Milošević
Soy-food and its isoflavones, genistein (G) and daidzein (D), were reported to exert mild cholesterol-lowering effect, but the underlying mechanism is still unclear. In this research, first we studied age-related alterations in hepatic cholesterol metabolism of acyclic middle-aged (MA) female rats. Then we tested if purified isoflavones may prevent or reverse these changes, and whether putative changes in hepatic thyroid hormone availability may be associated with this effect. Serum and hepatic total cholesterol (TChol), bile acid and cholesterol precursors, as well as serum TSH and T4 concentrations, hepatic deiodinase (Dio) 1 enzyme activity and MCT8 protein expression were determined by comparing data obtained for MA with young adult (YA) intact (IC) females...
March 20, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28336220/ureteroscopy-and-laser-stone-fragmentation-ursl-for-large-%C3%A2-1%C3%A2-cm-paediatric-stones-outcomes-from-a-university-teaching-hospital
#6
N C Featherstone, B K Somani, S J Griffin
INTRODUCTION: The treatment of large renal stones (≥1 cm) in paediatric patients is challenging. The usual treatment options include percutaneous nephrolithotomy (PCNL) or shockwave lithotripsy (SWL). There is a rise in the use of ureteroscopy and laser stone fragmentation (URSL) for paediatric stones; however, outcomes of treatment for large renal stones in this age group are still largely unknown. OBJECTIVE: To investigate the outcome of URSL for large paediatric renal stones ≥1 cm treated at the present institution over the last 5 years...
August 24, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28336112/evaluation-of-daily-ginger-consumption-for-the-prevention-of-chronic-diseases-in-adults-a-cross-sectional-study
#7
Yu Wang, Hongxia Yu, Xiulei Zhang, Qiyan Feng, Xiaoyan Guo, Shuguang Li, Rong Li, Dan Chu, Yunbo Ma
OBJECTIVES: The aim of this study was to assess daily ginger consumption and explore its correlation with chronic diseases among adults and to analyze further how different levels of ginger intake affect the prevalence of chronic diseases. METHODS: We examined the prevalence rate of chronic diseases (diabetes, hypertension, coronary heart disease [CHD], hyperlipidemia, cerebrovascular disease, fatty liver, anemia, and tumor), as well as the daily ginger intake in a large cross-sectional study...
April 2017: Nutrition
https://www.readbyqxmd.com/read/28335699/approaches-to-paraspinal-tumours-a-technical-note
#8
Arjun Dhar, Sumeet Pawar, Apurva Prasad, P S Ramani
Neurogenic tumours of the paraspinal space can occur in all age groups. It is common in adult population and relatively rare in elderly group. Usually they are benign, but in children, arising from the autonomic system, tends to be malignant in nature. Usually in adults, they arise from peripheral nerve sheath and are labelled as schwannomas. For a given tumour, determination of a correct surgical approach is mandatory to achieve a successful surgical outcome. Several factors like tumour size, histology, involvement of the bony spinal canal, etc...
March 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/28335658/dopamine-antagonists-for-treatment-resistance-in-autism-spectrum-disorders-review-and-focus-on-bdnf-stimulators-loxapine-and-amitriptyline
#9
Jessica A Hellings, L Eugene Arnold, Joan Han
Drug development is urgently needed for individuals with autism spectrum disorders (ASD) and psychiatric comorbidity, which often presents as aggression and self-injury. At the same time, most psychiatric medications are drugs that have been repurposed following clinical observations of efficacy for a new treatment purpose. Areas Covered: This review aims to provide an overview of dopamine antagonists, including classical and atypical, as well as unconventional antipsychotics in ASD, since they are a mainstay of treatment for such problems...
March 24, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28334811/causes-and-predictors-of-neonatal-post-neonatal-and-maternal-deaths-in-india-analysis-of-a-nationwide-district-level-household-survey-4-dlhs-4-2012-13
#10
Jaya P Tripathy, Sanskruti Mishra
Introduction: There is lack of reliable mortality estimates in India about maternal, neonatal and infant deaths. As we move towards achieving the targets under Sustainable Development Goals, information on cause of death is essential to prioritize our resources and planning. Therefore, the present study describes the causes and characteristics of neonatal, post-neonatal and maternal deaths in India. Methods: The study analysed nationwide District-Level Household Survey-4 conducted by the Ministry of Health and Family Welfare, Government of India, in 2014...
March 2, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28334685/serum-ifn-%C3%AE-induced-protein-10-ip-10-as-a-biomarker-for-severity-of-acute-respiratory-infection-in-healthy-adults
#11
Mary S Hayney, Kelsey M Henriquez, Jodi H Barnet, Tola Ewers, Heather M Champion, Sean Flannery, Bruce Barrett
BACKGROUND: The inflammatory chemokine, interferon-gamma inducible protein of 10kDa (IP-10), is a biomarker associated with several conditions. OBJECTIVES: This study investigated serum concentrations of IP-10 in healthy individuals who developed acute respiratory infection (ARI). The hypothesis is that serum IP-10 concentrations correlate with ARI severity and detection of viral pathogens. STUDY DESIGN: Data come from a randomized controlled trial measuring the effects of mindfulness meditation or exercise on ARI (Clinical Trials ID: NCT01654289)...
March 16, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28334475/the-influence-of-role-models-in-undergraduate-nurse-education
#12
Kirsten Jack, Claire Hamshire, Alison Chambers
AIMS AND OBJECTIVES: To explore the concept of role modelling in undergraduate nurse education and its effect on the personal and professional development of student nurses. BACKGROUND: Effective educative strategies are important for student nurses, who have to cope with learning in both clinical and university settings. Given the contemporary issues facing nurse education and practice in the United Kingdom (UK) it is timely and important to undertake pedagogical research into the concept of role modelling as an effective educative method...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28334323/interspecific-competition-between-ceratitis-capitata-and-two-bactrocera-spp-diptera-tephritidae-evaluated-via-adult-behavioral-interference-under-laboratory-conditions
#13
Hui Liu, Can Zhang, Bo-Hua Hou, Ge-Cheng Ou-Yang, Jun Ma
The Mediterranean fruit fly, Ceratitis capitata (Wiedemann), is considered one of the most invasive tephritid species. It has spread and established populations successfully throughout many of the tropical temperate regions, partially owing to the increase in global trading activity that facilitates diffusion of species. However, C. capitata has never been detected in China, even though some areas of the country have favorable climate and ample food resources. Historically, some researchers have hypothesized that the principal reasons for its absence are the defenses mounted by native Bactrocera species against C...
March 15, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28334159/characterization-of-white-matter-tracts-by-diffusion-mr-tractography-in-cat-and-ferret-that-have-similar-gyral-patterns
#14
Avilash Das, Emi Takahashi
The developmental relationships between gyral structures and white matter tracts have long been debated, but it is still difficult to discern whether they influence each other's development or are causally related. To explore this topic, this study used cats and ferrets as models for species that share similar gyral folding patterns and imaged with diffusion magnetic resonance imaging to compare white matter innervations in homologous gyri and other brain regions. Adult cat and ferret brains were analyzed via diffusion spectrum imaging tractography and homologous regions of interest were compared...
March 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28333286/high-prevalence-of-moderate-and-severe-depressive-and-anxiety-symptoms-in-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#15
Laura G Cooney, Iris Lee, Mary D Sammel, Anuja Dokras
Study question: Do women with polycystic ovary syndrome (PCOS) have an increased prevalence of moderate and severe depressive and anxiety symptoms compared with control women, and do these symptoms correlate with age, BMI, testosterone, hirsutism or insulin resistance (IR)? Summary answer: Women with PCOS have significantly increased odds of moderate and severe depressive and anxiety symptoms, independent of obesity, and the symptoms are weakly associated with age, BMI, elevated testosterone, hirsutism and IR...
March 9, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333284/revisiting-the-mutant-prevention-concentration-to-guide-dosing-in-childhood-tuberculosis
#16
Devan Jaganath, H Simon Schaaf, Peter R Donald
The mutant prevention concentration (MPC) is a well-known concept in the chemotherapy of many bacterial infections, but is seldom considered in relation to tuberculosis (TB) treatment, as the required concentrations are generally viewed as unachievable without undue toxicity. Early studies revealed single mutations conferring high MICs of first- and second-line anti-TB agents; however, the growing application of genomics and quantitative drug susceptibility testing in TB suggests a wide range of MICs often determined by specific mutations and strain type...
March 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28332944/homosexuality-religion-and-the-family-the-effects-of-religion-on-americans-appraisals-of-the-parenting-abilities-of-same-sex-couples
#17
Andrew L Whitehead
While a growing body of research focuses on Americans' attitudes toward same-sex couples as parents, very few include measures of religion and those that do fail to capture its multidimensional nature. Furthermore, many past studies rely on convenience samples of college students, or samples gathered outside the United States. Multivariate analyses of the 2012 General Social Survey-a nationally representative sample of adults in the United States-reveal that a slim majority of Americans still do not believe same-sex couples can parent as well as male-female couples and the religious beliefs, behaviors, and affiliations of Americans are significantly and at times differentially associated with appraisals of same-sex couples' parenting abilities...
March 23, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28332257/exomic-variants-of-an-elderly-cohort-of-brazilians-in-the-abraom%C3%A2-database
#18
Michel Satya Naslavsky, Guilherme Lopes Yamamoto, Tatiana Ferreira de Almeida, Suzana A M Ezquina, Daniele Yumi Sunaga, Nam Pho, Daniel Bozoklian, Tatiana Orli Milkewitz Sandberg, Luciano Abreu Brito, Monize Lazar, Danilo Vicensotto Bernardo, Edson Amaro, Yeda A O Duarte, Maria Lúcia Lebrão, Maria Rita Passos-Bueno, Mayana Zatz
Brazilians are highly admixed with ancestry from Europe, Africa, America, and Asia yet still underrepresented in genomic databanks. We hereby present a collection of exomic variants from 609 elderly Brazilians in a census-based cohort (SABE609) with comprehensive phenotyping. Variants were deposited in ABraOM (Online Archive of Brazilian Mutations), a web-based public database. Population representative phenotype and genotype repositories are essential for variant interpretation through allele frequency filtering; since elderly individuals are less likely to harbor pathogenic mutations for early and adult-onset diseases, such variant databases are of great interest...
March 23, 2017: Human Mutation
https://www.readbyqxmd.com/read/28331581/strong-bottom-up-influences-on-small-mammal-populations-state-space-model-analyses-from-long-term-studies
#19
John R Flowerdew, Tatsuya Amano, William J Sutherland
"Bottom-up" influences, that is, masting, plus population density and climate, commonly influence woodland rodent demography. However, "top-down" influences (predation) also intervene. Here, we assess the impacts of masting, climate, and density on rodent populations placed in the context of what is known about "top-down" influences. To explain between-year variations in bank vole Myodes glareolus and wood mouse Apodemus sylvaticus population demography, we applied a state-space model to 33 years of catch-mark-release live-trapping, winter temperature, and precise mast-collection data...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28330505/mosquito-borne-inkoo-virus-in-northern-sweden-isolation-and-whole-genome-sequencing
#20
Olivia Wesula Lwande, Göran Bucht, Clas Ahlm, Kristoffer Ahlm, Jonas Näslund, Magnus Evander
BACKGROUND: Inkoo virus (INKV) is a less known mosquito-borne virus belonging to Bunyaviridae, genus Orthobunyavirus, California serogroup. Studies indicate that INKV infection is mainly asymptomatic, but can cause mild encephalitis in humans. In northern Europe, the sero-prevalence against INKV is high, 41% in Sweden and 51% in Finland. Previously, INKV RNA has been detected in adult Aedes (Ae.) communis, Ae. hexodontus and Ae. punctor mosquitoes and Ae. communis larvae, but there are still gaps of knowledge regarding mosquito vectors and genetic diversity...
March 23, 2017: Virology Journal
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