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https://www.readbyqxmd.com/read/28749247/evaluating-the-effectiveness-of-a-community-based-hygiene-promotion-program-in-a-rural-salvadoran-setting
#1
Elizabeth L Andrade, Jeffrey B Bingenheimer, Mark C Edberg, Kathryn L Zoerhoff, Emily M Putzer
There has been considerable progress in the reduction of diarrheal disease among children under five through health and nutrition interventions. However, diarrheal disease is still the second leading cause of child death worldwide. There is growing recognition that comprehensive hygiene behavior improvements should be integral to prevention efforts, but the effectiveness of different approaches for hygiene promotion is still being established. Hygiene risk practices vary across settings, suggesting that prevention strategies should be adapted to local contexts using community-based approaches...
July 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28749114/characteristics-and-outcomes-of-patients-with-hematological-malignancies-admitted-for-intensive-care-a-single-centre-experience
#2
Shafaq Maqsood, Farhana Badar, Abdul Hameed
Background and Purpose: Patients with hematological malignancies admitted to an intensive care unit (ICU) generally have a high mortality rate. The aim of our study was to assess the characteristics and outcomes of such patients and to identify factors predicting ICU mortality. Material and Methods: This retrospective chart review was conducted in the intensive care unit (ICU) of Shaukat Khanum Memorial Cancer Hospital and Research Centre over a period of 5 years, from January 2010 to January 2015. Results: Characteristics :A total of 213 patients were included in this study...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749082/impact-of-warm-ischemia-time-on-postoperative-renal-function-after-partial-nephrectomy-for-clinical-t1-renal-cell-carcinoma-a-propensity-score-matched-study
#3
Hakmin Lee, Byung Do Song, Seok-Soo Byun, Sang Eun Lee, Sung Kyu Hong
OBJECTIVES: To preserve renal function, partial nephrectomy (PN) is recommended to patients with small renal masses. However, controversy still exists as to whether prolonged ischemia time adversely affects the incidence of chronic kidney disease (CKD) after PN. We analyzed the effect of prolonged warm ischemia time (WIT) on long-term renal function following PN. MATERIALS AND METHODS: We reviewed data from 1,816 patients who underwent PN for clinical T1 renal tumor...
July 27, 2017: BJU International
https://www.readbyqxmd.com/read/28748761/tyrosinase-electrochemical-biosensors-monitoring-medicinally-significant-substances
#4
Milan Sýs, Karel Vytřas
Nowadays in biosensing, development of analytical techniques is focused on improvement for monitoring biologically active species in living organisms, especially in real time analysis. This article provides an overview of applications of electrochemical tyrosinase biosensors in analysis of medicinally significant substances, otherwise also known as biomarkers. At the beginning, special attention is paid to characterisation of the tyrosinase enzyme, explanation of reaction mechanisms of tyrosinase with various types of electrochemical transducers and techniques needed for stable immobilization of this biocatalyst on the transducer surface used...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748759/targeting-kinase-activating-genetic-lesions-to-improve-therapy-of-pediatric-acute-lymphoblastic-leukemia
#5
Franca Raffaella, Natasa Karas Kuzelicki, Claudio Sorio, Eleonora Toffoletti, Oksana Montecchini, Alice Poropat, Marco Rabusin, Debora Curci, Dino Paladin, Gabriele Stocco, Giuliana Decorti
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children, characterized by an abnormal proliferation of immature lymphoid cells. Thanks to risk-adapted combination chemotherapy treatments currently used, survival at 5 years has reached 90%. ALL is a heterogeneous disease from a genetic point of view: patients' lymphoblasts may harbor in fact several chromosomal alterations, some of which have prognostic and therapeutic value. Of particular importance is the translocation t(9;22)(q34;q11...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748430/inicu-integrated-neonatal-care-unit-capturing-neonatal-journey-in-an-intelligent-data-way
#6
Harpreet Singh, Gautam Yadav, Raghuram Mallaiah, Preetha Joshi, Vinay Joshi, Ravneet Kaur, Suneyna Bansal, Samir K Brahmachari
Neonatal period represents first 28 days of life, which is the most vulnerable time for a child's survival especially for the preterm babies. High neonatal mortality is a prominent and persistent problem across the globe. Non-availability of trained staff and infrastructure are the major recognized hurdles in the quality care of these neonates. Hourly progress growth charts and reports are still maintained manually by nurses along with continuous calculation of drug dosage and nutrition as per the changing weight of the baby...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28748149/the-prognostic-value-of-residual-coronary-stenoses-after-functionally-complete-revascularisation
#7
EDITORIAL
Dennis T L Wong
Fractional flow reserve (FFR) has become the gold standard for functional assessment of coronary artery stenosis. Studies have confirmed the superiority of FFR guided percutaneous coronary intervention (PCI) compared to angiography guided PCI. Due to the high cost of FFR, it is not economically viable for FFR to be incorporated into every routine invasive coronary angiography. As a result, visual estimation of diameter stenosis on invasive coronary angiography still remains the cornerstone for decision making regarding revascularisation treatment for patients...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28748122/asymptomatic-hyperuricemia-and-chronic-kidney-disease-narrative-review-of-a-treatment-controversial
#8
REVIEW
Theodoros Eleftheriadis, Spyridon Golphinopoulos, Georgios Pissas, Ioannis Stefanidis
Today there is plausible evidence both on experimental and epidemiological basis, that hyperuricemia represents a risk factor for the development and progression of chronic kidney disease (CKD). Nevertheless, the role of serum uric acid lowering treatment in CKD is still a matter of serious controversy. Review of randomised controlled trials, suggests that there may be an improvement of renal function with allopurinol treatment in CKD stage 3-5. However, these studies have included a relatively limited number of participants and provide insufficient information on adverse events and on the incidence of the end stage renal disease...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748119/uric-acid-in-the-pathogenesis-of-metabolic-renal-and-cardiovascular-diseases-a-review
#9
REVIEW
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim
The association between uric acid (UA) on one side and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized. However, the causal relationship between UA and these different clinical problems is still debatable. The recent years have witnessed hundreds of experimental and clinical trials that favored the opinion that UA is a probable player in the pathogenesis of these disease entities. These studies disclosed the strong association between hyperuricemia and metabolic syndrome (MS), obesity, Htn, type 2 diabetes mellitus (DM), non-alcoholic fatty liver disease, hypertriglyceridemia, acute kidney injury, chronic kidney disease (CKD), coronary heart disease (CHD), heart failure and increased mortality among cardiac and CKD patients...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748063/field-application-of-the-micro-biological-survey-method-for-the-assessment-of-the-microbiological-safety-of-different-water-sources-in-horn-of-africa-and-the-evaluation-of-the-effectiveness-of-moringa-oleifera-in-drinking-water-purification
#10
Francesca Losito, Alyexandra Arienzo, Daniela Somma, Lorenza Murgia, Ottavia Stalio, Paolo Zuppi, Elisabetta Rossi, Giovanni Antonini
Water monitoring requires expensive instrumentations and skilled technicians. In developing Countries as Africa, the severe economic restrictions and lack of technology make water safety monitoring approaches applied in developed Countries, still not sustainable. The need to develop new methods that are suitable, affordable, and sustainable in the African context is urgent. The simple, economic and rapid Micro Biological Survey (MBS) method does not require an equipped laboratory nor special instruments and skilled technicians, but it can be very useful for routine water analysis...
June 23, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28747982/comparative-study-of-fatty-liver-induced-by-methionine-and-choline-deficiency-in-c57bl-6n-mice-originating-from-three-different-sources
#11
Sou Hyun Kim, Yong Lim, Ju Bin Park, Jae-Hwan Kwak, Keuk-Jun Kim, Joung-Hee Kim, HyunKeun Song, Joon Young Cho, Dae Youn Hwang, Kil Soo Kim, Young-Suk Jung
Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in the absence of significant alcohol consumption and frequently progresses to steatohepatitis, liver fibrosis, and hepatocellular carcinoma. Although many studies have been conducted to better understand NAFLD since it was first recognized, there are still many gaps in knowledge of etiology, prognosis, prevention and treatment...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747954/recent-trends-in-the-prevalence-of-chronic-obstructive-pulmonary-disease-in-korea
#12
REVIEW
Yong Il Hwang, Yong Bum Park, Kwang Ha Yoo
Chronic obstructive pulmonary disease (COPD) had been considered the only major disease that is continuing to increase in prevalence. There were a few studies about the change of the prevalence of COPD, which showed the prevalence of COPD did not increase. In this review, we report on the trends in the prevalence of COPD in Korea using the data from Korea National Health and Nutrition Examination Survey (KNHANES). The prevalence of COPD in 2015 was 13.4% (male, 21.6%; female, 5.8%). The prevalence of COPD did not change much, which ranged from 13...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747901/could-the-recent-zika-epidemic-have-been-predicted
#13
Ángel G Muñoz, Madeleine C Thomson, Anna M Stewart-Ibarra, Gabriel A Vecchi, Xandre Chourio, Patricia Nájera, Zelda Moran, Xiaosong Yang
Given knowledge at the time, the recent 2015-2016 zika virus (ZIKV) epidemic probably could not have been predicted. Without the prior knowledge of ZIKV being already present in South America, and given the lack of understanding of key epidemiologic processes and long-term records of ZIKV cases in the continent, the best related prediction could be carried out for the potential risk of a generic Aedes-borne disease epidemic. Here we use a recently published two-vector basic reproduction number model to assess the predictability of the conditions conducive to epidemics of diseases like zika, chikungunya, or dengue, transmitted by the independent or concurrent presence of Aedes aegypti and Aedes albopictus...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28747690/postmortem-genetic-analysis-of-sudden-unexpected-death-in-infancy-neonatal-genetic-screening-may-enable-the-prevention-of-sudden-infant-death
#14
Yuki Oshima, Takuma Yamamoto, Taisuke Ishikawa, Hiroyuki Mishima, Aya Matsusue, Takahiro Umehara, Takehiko Murase, Yuki Abe, Shin-Ichi Kubo, Koh-Ichiro Yoshiura, Naomasa Makita, Kazuya Ikematsu
Tandem mass screening has recently been started in Japan, but genetic screening has yet to be widely performed in neonates and many unexpected deaths are still being reported. We previously reported two cases of sudden infant death that may have been prevented had newborn screening been performed. In this study, we retrospectively reviewed 71 cases of sudden infant death for 66 arrhythmia- and 63 metabolic disease-related genes to identify how many cases of sudden infant death may have been prevented had mass screening been performed...
July 27, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28747502/permissivity-of-dpp4-orthologs-to-mers-coronavirus-is-governed-by-glycosylation-and-other-complex-determinants
#15
Kayla M Peck, Trevor Scobey, Jesica Swanstrom, Kara L Jensen, Christina L Burch, Ralph S Baric, Mark T Heise
Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. While bat, camel, and human DPP4 support MERS-CoV infection, several DPP4 orthologs, including mouse, ferret, hamster, and guinea pig, do not. Previous work revealed that glycosylation of mouse DPP4 plays a role in blocking MERS-CoV infection. Here, we test whether glycosylation also acts as a determinant of permissivity for ferret, hamster, and guinea pig DPP4. We find that while glycosylation plays an important role in these orthologs, additional sequence and structural determinants impact their ability to act as functional receptors for MERS-CoV...
July 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28747403/agmatine-multifunctional-arginine-metabolite-and-magic-bullet-in-clinical-neuroscience
#16
REVIEW
Gregor Laube, Hans-Gert Bernstein
Agmatine, the decarboxylation product of arginine, was largely neglected as an important player in mammalian metabolism until the mid-1990s, when it was re-discovered as an endogenous ligand of imidazoline and α2-adrenergic receptors. Since then, a wide variety of agmatine-mediated effects have been observed, and consequently agmatine has moved from a wallflower existence into the limelight of clinical neuroscience research. Despite this quantum jump in scientific interest, the understanding of the anabolism and catabolism of this amine is still vague...
July 26, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28747289/retrospective-evaluation-of-hairy-cell-leukemia-patients-treated-with-3-different-first-line-treatment-modalities-in-the-last-two-decades-a-single-center-experience
#17
Şeniz Öngören, Ahmet Emre Eşkazan, Selin Berk, Tuğrul Elverdi, Ayşe Salihoğlu, Muhlis Cem Ar, Zafer Başlar, Yıldız Aydın, Nükhet Tüzüner, Teoman Soysal
OBJECTIVE: In this study, we retrospectively analysed the clinical outcome, treatment responses, infectious complications and survival rates of seventy-one hairy cell leukemia (HCL) cases. MATERIALS AND METHODS: Sixty-six patients received a first-line treatment, and 2-chlorodeoxyadenosine (cladribine-2-CdA) was administered in thirty-one, nineteen patients received interferon-alpha (INF-α), splenectomy was performed in 16 cases, and rituximab was used in one. RESULTS: Although the highest overall response rate (ORR) was observed in patients receiving upfront 2-CdA, ORRs were comparable in 2-CdA, INF-α, and splenectomy subgroups...
July 27, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28747268/screening-of-depression-in-cardiology-a-study-on-617-cardiovascular-patients
#18
Valentina Tesio, Sebastiano Marra, Stefania Molinaro, Riccardo Torta, Fiorenzo Gaita, Lorys Castelli
BACKGROUND: Depression screening in the cardiovascular disease (CVD) care setting is under-performed, also because the issue of the optimal screening tools cut-off is still open. We analysed which HADS (Hospital Anxiety and Depression Scale) total score cut-off value shows the best properties in two groups of 357 Acute Coronary Syndrome (ACS) and 260 Chronic Coronary Artery Disease (CAD) hospitalized patients. METHODS: A Receiver Operating Characteristics (ROC) curve was plotted for both groups using the Montgomery-Asberg Depression Rating Scale (MADRS) as the criterion...
July 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28747234/integrating-multiple-criteria-for-the-characterization-of-psammotettix-populations-in-european-cereal-fields
#19
I Abt, M Derlink, R Mabon, M Virant-Doberlet, E Jacquot
The wheat dwarf disease is among the most damaging diseases in cereals. Its aetiological agent is the Wheat dwarf virus (WDV), which is exclusively transmitted from plant to plant by leafhoppers from the genus Psammotettix (Hemiptera, Cicadellidae). The parameters linked to the WDV/Psammotettix pathosystem are still poorly understood. We studied Psammotettix individuals collected in wheat and barley fields in France and, as a comparison, from grassland at agroecological interface in West Slovenia. Species identity of males and females has been determined using multiple criteria...
July 27, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28746885/injectable-hydrogel-based-on-quaternized-chitosan-gelatin-and-dopamine-as-localized-drug-delivery-system-to-treat-parkinson-s-disease
#20
Yizhuo Ren, Xin Zhao, Xiaofeng Liang, Peter X Ma, Baolin Guo
There is still an enormous demand for designing materials to the treatment of Parkinson's disease, and dopamine-based injectable polysaccharide hydrogels as localized drug delivery system have huge potential. Here, we developed a facile approach to prepare dopamine-based and polydopamine crosslinked injectable hydrogels by simply oxidizing a mixture of quaternized chitosan, gelatin and dopamine under physiological conditions. These injectable quaternized hydrogels showed stable mechanical strength by rheometer and exhibited good degradability evaluated by in vitro degradation test...
July 23, 2017: International Journal of Biological Macromolecules
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