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https://www.readbyqxmd.com/read/28220378/glaucoma-and-driving-are-we-documenting-driving-status-and-advising-patients-with-glaucoma-appropriately-about-their-driving
#1
Amun Sachdev, Mazen Tahhan, Velota Ching Tak Sung
PURPOSE: Guidelines from the Driver and Vehicle Licensing Agency (DVLA) in the UK state that patients with bilateral glaucomatous visual field defects must stop driving unless confirmed able to meet minimum visual field requirements. Guidelines from the Royal College of Ophthalmologists state that ophthalmologists must consider driving status in every consultation, provide appropriate information if visual problems may affect driving and document any advice that has been given. The authors aimed to investigate whether in glaucoma clinics: (1) driving status is being documented, (2) appropriate patients have been advised to inform DVLA and (3) there is documentation that this advice was provided...
February 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28220374/lipopolysaccharide-activates-toll-like-receptor-4-and-prevents-cardiac-fibroblast-to-myofibroblast-differentiation
#2
Samir Bolívar, Roxana Santana, Pedro Ayala, Rodolfo Landaeta, Pía Boza, Claudio Humeres, Raúl Vivar, Claudia Muñoz, Viviana Pardo, Samuel Fernandez, Renatto Anfossi, Guillermo Diaz-Araya
Bacterial lipopolysaccharide (LPS) is a known ligand of Toll-like receptor 4 (TLR4) which is expressed in cardiac fibroblasts (CF). Differentiation of CF to cardiac myofibroblasts (CMF) is induced by transforming growth factor-β1 (TGF-β1), increasing alpha-smooth muscle actin (α-SMA) expression. In endothelial cells, an antagonist effect between LPS-induced signaling and canonical TGF-β1 signaling was described; however, it has not been studied whether in CF and CMF the expression of α-SMA induced by TGF-β1 is antagonized by LPS and the mechanism involved...
February 20, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28219306/infection-after-fracture-osteosynthesis-part-ii
#3
Christian Fang, Tak-Man Wong, Kelvin Kw To, Samson Sy Wong, Tak-Wing Lau, Frankie Leung
In the first part of this article, we have discussed the pathogenesis, clinical presentation, diagnosis and classification of infection after fracture osteosynthesis with implants, termed here as osteosynthesis-associated infection (OAI). Prolonged antibiotic treatment is usually necessary. Implant retention and maintenance of fracture stability to allow for fracture healing in spite of infection are allowed for OAI. Depending on the severity of infection, status of fracture healing and host status, the treatment follows five common pathways...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28219061/establishing-prenatal-surgery-for-myelomeningocele-in-asia-the-singapore-consensus
#4
Tuangsit Wataganara, Suresh Seshadri, Tak Yeung Leung, Citra Matter, Monawat Ngerncham, Namtip Triyasunant, Padmakar Vidyadhar Mali, Agnhitori Biswas, Katika Nawapun, Nisarat Phithakwatchara, Alan W Flake, Mark P Johnson, Arijit Biswas, Mahesh Choolani
OBJECTIVES: The Management of Myelomeningocele Study (MOMS Trial) has inspired many fetal therapy centers (FTCs) to offer open fetal surgery for myelomeningocele (MMC). This is an initial effort to create a candidate model that can be applicable to many parts of Asia. MATERIAL AND METHODS: A limited selection of specialists from 4 established FTCs in Thailand, Hong Kong, India, and Singapore met for a round table discussion. Experts from Children's Hospital of Philadelphia (CHOP) involved in the Trial moderated the session...
February 21, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28215362/efficacy-and-safety-of-sirukumab-in-patients-with-active-rheumatoid-arthritis-refractory-to-anti-tnf-therapy-sirround-t-a-randomised-double-blind-placebo-controlled-parallel-group-multinational-phase-3-study
#5
Daniel Aletaha, Clifton O Bingham, Yoshiya Tanaka, Prasheen Agarwal, Regina Kurrasch, Paul P Tak, Sharon Popik
BACKGROUND: Sirukumab, a human monoclonal antibody that selectively binds to the interleukin-6 cytokine with high affinity, is under development for the treatment of rheumatoid arthritis and other diseases. We aimed to assess the efficacy and safety of sirukumab for rheumatoid arthritis in a phase 3 study (SIRROUND-T). METHODS: We did a randomised, double-blind, placebo-controlled, parallel-group, multicentre study at 183 hospitals and private rheumatology clinics in 20 countries (Argentina, Australia, Austria, Belgium, Canada, France, Germany, Italy, Japan, Lithuania, Mexico, Netherlands, Poland, Portugal, Russia, South Korea, Spain, Taiwan, UK, and USA)...
February 15, 2017: Lancet
https://www.readbyqxmd.com/read/28215118/infection-after-fracture-osteosynthesis-part-i
#6
Christian Fang, Tak-Man Wong, Tak-Wing Lau, Kelvin Kw To, Samson Sy Wong, Frankie Leung
Bone and surgical site infections after osteosynthesis are notoriously difficult to manage and pose a tremendous burden in fracture management. In this article, we use the term osteosynthesis-associated infection (OAI) to refer to this clinical entity. While relatively few surgically treated fractures become infected, it is challenging to perform a rapid diagnosis. Optimal management strategies are complex and highly customized to each scenario and take into consideration the status of fracture union, the presence of hardware and the degree of mechanical stability...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28214898/early-development-of-parvalbumin-somatostatin-and-cholecystokinin-expressing-neurons-in-rat-brain-following-prenatal-immune-activation-and-maternal-iron-deficiency
#7
Patricia Boksa, Ying Zhang, Dominique Nouel, Alice Wong, Tak Pan Wong
Prenatal maternal infection and maternal iron deficiency during pregnancy are 2 early environmental insults associated with increased risk for schizophrenia in offspring. Substantial evidence suggests that abnormalities in inhibitory γ-aminobutyric acid (GABA) interneuron function, especially in the parvalbumin subtype of GABA interneuron, both developmentally and in adulthood, may contribute mechanistically to cognitive deficits and psychotic symptoms in schizophrenia. This study used a rat model to test whether prenatal immune activation with lipopolysaccharide (LPS; at gestation days, GD, 15 and 16) or maternal iron deficiency (from GD2 to postnatal day P7) or the combination of both insults alters major subtypes of GABAergic interneurons (parvalbumin, somatostatin, cholecystokinin) in brain regions relevant to schizophrenia (medial and dorsolateral prefrontal cortex [PFC], hippocampal CA1 and dentate gyrus, ventral subiculum) in offspring at P14 or P28...
February 18, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28211448/cx-5461-is-a-dna-g-quadruplex-stabilizer-with-selective-lethality-in-brca1-2-deficient-tumours
#8
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia, Farhia Kabeer, Daniel Lai, Priscilla Soriano, Judit Banáth, Derek S Chiu, Damian Yap, Daniel D Le, Frank B Ye, Anni Zhang, Kelsie Thu, John Soong, Shu-Chuan Lin, Angela Hsin Chin Tsai, Tomo Osako, Teresa Algara, Darren N Saunders, Jason Wong, Jian Xian, Marcel B Bally, James D Brenton, Grant W Brown, Sohrab P Shah, David Cescon, Tak W Mak, Carlos Caldas, Peter C Stirling, Phil Hieter, Shankar Balasubramanian, Samuel Aparicio
G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect. Here, we show that CX-5461 is a G-quadruplex stabilizer, with specific toxicity against BRCA deficiencies in cancer cells and polyclonal patient-derived xenograft models, including tumours resistant to PARP inhibition. Exposure to CX-5461, and its related drug CX-3543, blocks replication forks and induces ssDNA gaps or breaks...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28207430/evaluation-of-augmented-pulse-pressure-variation-using-the-valsalva-manoeuvre-as-a-predictor-of-fluid-responsiveness-under-open-chest-conditions-a-prospective-observational-study
#9
Jeong Jin Min, Tae Kyong Kim, Jong-Hwan Lee, Jiyeon Park, Hyun Sung Cho, Wook Sung Kim, Young Tak Lee
BACKGROUND: Pulse pressure variation (PPV) is a well known dynamic preload indicator of fluid responsiveness. However, its usefulness in open-chest conditions remains controversial. OBJECTIVE: We evaluated whether augmented PPV during a Valsalva manoeuvre can predict fluid responsiveness after sternotomy. DESIGN: A prospective, observational study. SETTING: Single-centre trial, study period from October 2014 to June 2015...
February 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28206647/fasiglifam-tak-875-mechanistic-investigation-and-retrospective-identification-of-hazards-for-drug-induced-liver-injury-dili
#10
Monicah A Otieno, Jan Snoeys, Wing Lam, Avi Ghosh, Mark R Player, Alessandro Pocai, Rhys Salter, Damir Simic, Hollie Skaggs, Bhanu Singh, Lim Heng-Keang
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28203745/spontaneous-respiration-using-intravenous-anaesthesia-and-hi-flow-nasal-oxygen-strive-hi-maintains-oxygenation-and-airway-patency-during-management-of-the-obstructed-airway-an-observational-study
#11
A W G Booth, K Vidhani, P K Lee, C-M Thomsett
No abstract text is available yet for this article.
March 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28196704/toll-like-receptor-4-antagonist-tak-242-inhibits-autoinflammatory-symptoms-in-ditra
#12
Akitaka Shibata, Kazumitsu Sugiura, Yasuhide Furuta, Yoshiko Mukumoto, Osamu Kaminuma, Masashi Akiyama
BACKGROUND: IL36RN encodes the IL-36 receptor antagonist (IL-36Ra), and loss-of-function mutations in IL36RN define a recessively inherited autoinflammatory disease named "deficiency of IL-36Ra" (DITRA). DITRA causes systemic autoinflammatory diseases, including generalized pustular psoriasis (GPP), an occasionally life-threatening disease that is characterized by widespread sterile pustules on the skin, fever and other systemic symptoms. GPP can present at any age, and provocative factors include various infections, medicines and pregnancy...
February 11, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28193895/p53-regulates-the-cardiac-transcriptome
#13
Tak W Mak, Ludger Hauck, Daniela Grothe, Filio Billia
The tumor suppressor Trp53 (p53) inhibits cell growth after acute stress by regulating gene transcription. The mammalian genome contains hundreds of p53-binding sites. However, whether p53 participates in the regulation of cardiac tissue homeostasis under normal conditions is not known. To examine the physiologic role of p53 in adult cardiomyocytes in vivo, Cre-loxP-mediated conditional gene targeting in adult mice was used. Genome-wide transcriptome analyses of conditional heart-specific p53 knockout mice were performed...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28192445/vitamin-d-deficiency-is-significantly-associated-with-depression-in-patients-with-chronic-kidney-disease
#14
Jong Hyun Jhee, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Su-Young Jung, Youn Kyung Kee, Chang-Yun Yoon, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
BACKGROUND: Depression is reported to be the most common psychological problem in patients with chronic kidney disease (CKD). Several studies have reported that lower levels of serum vitamin D are significantly associated with depression. Both vitamin D deficiency and depression are prevalent in patients with CKD, yet the relationship between these two factors remains poorly understood. This study aimed to investigate the association between vitamin D levels and depression among CKD patients...
2017: PloS One
https://www.readbyqxmd.com/read/28188407/phase-ii-study-of-the-antibody-drug-conjugate-tak-264-mln0264-in-patients-with-metastatic-or-recurrent-adenocarcinoma-of-the-stomach-or-gastroesophageal-junction-expressing-guanylyl-cyclase-c
#15
Khaldoun Almhanna, Maria Luisa Limon Miron, David Wright, Antonio Cubillo Gracian, Richard A Hubner, Jean-Luc Van Laethem, Carolina Muriel López, Maria Alsina, Frederico Longo Muñoz, Johanna Bendell, Irfan Firdaus, Wells Messersmith, Zhan Ye, Adedigbo A Fasanmade, Hadi Danaee, Thea Kalebic
Background The first-in-class antibody-drug conjugate TAK-264 (formerly MLN0264) consists of an antibody targeting guanylyl cyclase C (GCC) conjugated to monomethyl auristatin E (MMAE) via a peptide linker. This phase II study evaluated the efficacy and safety of TAK-264 in patients with adenocarcinoma of the stomach or gastroesophageal junction expressing GCC, who had progressed on ≥1 line of prior therapy. Methods This study used a two-stage design, with an interim analysis conducted after stage I to determine whether to continue to stage II or discontinue on the grounds of futility...
February 11, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28187735/prognostic-value-of-alcohol-consumption-and-some-other-dietary-habits-for-survival-in-a-cohort-of-chinese-men-with-lung-cancer
#16
Wentao Li, Lap Ah Tse, Joseph S K Au, Kai Shing Yu, Feng Wang, Ignatius Tak-Sun Yu
BACKGROUND: Alcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence. However, the effects of these habits on lung cancer prognosis have been studied rarely. The purpose of this study was to address these gaps in knowledge. METHODS: We studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer. Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol, fresh fruits or vegetables, meat, and fried or preserved food...
February 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28187098/preoperative-predictive-factors-for-complete-cytoreduction-and-survival-outcome-in-epithelial-ovarian-tubal-and-peritoneal-cancer-after-neoadjuvant-chemotherapy
#17
Min-Hyun Baek, Shin-Wha Lee, Jeong-Yeol Park, Chae Chun Rhim, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: The study aims to identify preoperative predictors of complete cytoreduction and early recurrence and death in epithelial ovarian, tubal, and peritoneal cancer after neoadjuvant chemotherapy (NACT). METHODS: We performed a retrospective analysis of 85 patients who underwent 3 cycles of NACT. Patients were divided into 2 groups according to residual tumor at interval debulking surgery (IDS), and clinicopathologic, surgical, and follow-up data were compared...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28186880/generative-local-metric-learning-for-nearest-neighbor-classi%C3%AF-cation
#18
Yung-Kyun Noh, Byoung-Tak Zhang, Daniel D Lee
We consider the problem of learning a local metric in order to enhance the performance of nearest neighbor classification. Conventional metric learning methods attempt to separate data distributions in a purely discriminative manner; here we show how to take advantage of information from parametric generative models. We focus on the bias in the information-theoretic error arising from finite sampling effects, and find an appropriate local metric that maximally reduces the bias based upon knowledge from generative models...
February 8, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28186879/fluid-dynamic-models-for-bhattacharyya-based-discriminant-analysis
#19
Yung-Kyun Noh, Jihun Hamm, Frank Park, Byoung-Tak Zhang, Daniel D Lee
Classical discriminant analysis attempts to discover a low-dimensional subspace where class label information is maximally preserved under projection. Canonical methods for estimating the subspace optimize an information-theoretic criterion that measures the separation between the class-conditional distributions. Unfortunately, direct optimization of the information-theoretic criteria is generally non-convex and intractable in high-dimensional spaces. In this work, we propose a novel, tractable algorithm for discriminant analysis that considers the class-conditional densities as interacting fluids in the high-dimensional embedding space...
February 8, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28186541/comparison-of-outcomes-between-the-incremental-and-thrice-weekly-initiation-of-hemodialysis-a-propensity-matched-study-of-a-prospective-cohort-in-korea
#20
Ji In Park, Jung Tak Park, Yong-Lim Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee
No abstract text is available yet for this article.
February 1, 2017: Nephrology, Dialysis, Transplantation
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