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https://www.readbyqxmd.com/read/28742154/lipopolysaccharide-inhibits-myogenic-differentiation-of-c2c12-myoblasts-through-the-toll-like-receptor-4-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-and-myoblast-derived-tumor-necrosis-factor-%C3%AE
#1
Yuko Ono, Kazuho Sakamoto
BACKGROUND: Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or with various endogenous diseases that are associated with metabolic endotoxemia. Involuntary loss of skeletal muscle, termed muscle wasting, is commonly observed in these conditions, suggesting that circulating LPS might play an essential role in its development. Although impairment of muscle regeneration is an important determinant of skeletal muscle wasting, it is unclear whether LPS affects this process and, if so, by what mechanism...
2017: PloS One
https://www.readbyqxmd.com/read/28741262/maternal-mental-quality-of-life-mediates-the-associations-between-intimate-partner-abuse-against-mothers-and-their-children-s-behaviours-and-quality-of-life-in-low-income-chinese-families
#2
Vivian Yawei Guo, Esther Yee Tak Yu, Rosa Sze Man Wong, Patrick Ip, Agnes Fung Yee Tiwari, Carlos King Ho Wong, Colman Siu Cheung Fung, Wilfred Hing Sang Wong, Cindy Lo Kuen Lam
PURPOSE: To explore the association between maternal intimate partner abuse (IPA) and their children's health-related quality of life (HRQOL) and behavioural problem, and to establish a mediation model and investigate the mediating role of mothers' HRQOL on this association. METHODS: A cross-sectional study was conducted on 197 mothers of 227 children (112 boys and 115 girls) from low-income Chinese families. The mothers were asked to complete the 5-item abuse assessment screen questionnaire for the presence of IPA, the Chinese (Hong Kong) version of 12-item Short-Form Health Survey (SF-12) for their HRQOL and a structured socio-demographics questionnaire...
July 24, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28738900/impact-of-ablation-duration-on-rhythm-outcome-after-concomitant-maze-procedure-using-cryoablation-in-patients-with-persistent-atrial-fibrillation
#3
Dong Seop Jeong, Ji Hoon You, Chang-Seok Jeon, Pyo Won Park, Kiick Sung, Wook Sung Kim, Young Tak Lee
BACKGROUND: The aim of this study was to evaluate the impact of ablation duration during a maze procedure using a nitrous oxide-based cryosurgical system. METHODS: From May 2001 to December 2006, 256 consecutive patients who underwent a concomitant maze procedure using nitrous oxide-based cryoablation for chronic atrial fibrillation (AF) during cardiac surgery were enrolled. The ablation duration for each lesion was between 120 s at -60 °C in 140 patients (control group) and 160 s in 116 patients (long duration group)...
July 24, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28735356/evaluation-of-anthelmintic-antimicrobial-and-antioxidant-activity-of-chenopodium-album
#4
Bashir A Lone, M Z Chishti, Fayaz Ahmad Bhat, Hidayatullah Tak, Suhaib A Bandh, Abida Khan
The objective of this study was to evaluate the anthelmintic, antimicrobial and antioxidant activities of Chenopodium album against gastrointestinal nematodes of sheep and some pathogenic microbes. A worm motility inhibition assay was used for in vitro study, and a faecal egg count reduction assay was used for an in vivo study. Various concentrations ranging from 100 to 500 μg/ml of the extract were subjected to antimicrobial screening by disc diffusion method against four selected bacterial (Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas multocida and Escherichia coli) and two fungal (Aspergillus flavus and Candida albicans) strains in order to estimate the medicinal potential of the herb...
July 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28734155/activation-of-mtor-is-involved-in-anti-%C3%AE-2gpi-%C3%AE-2gpi-induced-expression-of-tissue-factor-and-il-8-in-monocytes
#5
Longfei Xia, Hong Zhou, Ting Wang, Yachao Xie, Ting Wang, Xiaoyan Wang, Jinchuan Yan
Previous study has demonstrated that activation of the mammalian target of rapamycin (mTOR) pathway in endothelial cells (ECs) results in the formation of chronic vascular lesions associated with antiphospholipid syndrome (APS). In addition, it has been shown that stimulation of monocytes and ECs by antiphospholipid antibodies (aPL) leads to a prothrombotic and proinflammatory state and up-regulated expression of tissue factor (TF) and inflammatory cytokines. However, the role of mTOR in pathogenic mechanisms of APS remains largely unexplored...
June 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28732026/investigation-of-opioid-use-and-long-term-oncologic-outcomes-for-non-small-cell-lung-cancer-patients-treated-with-surgery
#6
Tak Kyu Oh, Jae Hyun Jeon, Jong Mog Lee, Moon Soo Kim, Jee Hee Kim, Hyeyeon Cho, Seong-Eun Kim, Woosik Eom
Opioids are commonly used for postoperative pain control in cancer patients. In addition to pain control, an association between opioid use and long-term oncologic outcomes, such as recurrence or overall survival, has been postulated. The aim of this study was to determine whether postoperative opioid use in patients with non-small cell lung cancer is associated with long-term oncologic outcomes, including recurrence and death. Data obtained from 1009 medical records of patients who underwent curative resection at the National Cancer Center, Korea between January 2006 and December 2010 were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28731110/a-redox-controlled-electrolyte-for-plasmonic-enhanced-dye-sensitized-solar-cells
#7
Yuqiao Fu, Siu-Pang Ng, Guangyu Qiu, Tak-Fu Hung, Chi-Man Lawrence Wu, Chun-Sing Lee
Plasmonic enhanced dye-sensitized solar cells (DSSCs) with metallic nanostructures suffer from corrosion problems, especially with the presence of the iodine/triiodide redox couple in the electrolyte. Herein, we introduce an alternative approach by compensating the corrosion with a modified liquid electrolyte. In contrast to the existing method of surface preservation for plasmonic nanostructures, the redox-controlled electrolyte (RCE) contains iodoaurate intermediates, i.e. gold(i) diiodide (AuI2(-)) and gold(iii) tetraiodide (AuI4(-)) with optimal concentrations, such that these intermediates are readily reduced to gold nanoparticles during the operation of DSSCs...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28730971/apoptosis-and-anti-cancer-drug-discovery-the-power-of-medicinal-fungi-and-plants
#8
Jack Ho Wong, Stephen Cho Wing Sze, Tzi Bun Ng, Randy Chi Fai Cheung, Chit Tam, Kalin Yanbo Zhang, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye, Hexiang Wang, Fang Liu, David Wai Chan, Hextan Yuen Sheung Ngan, Ou Sha, Guohui Li, Ryan Tse, Tak Fu Tse, Helen Chan
The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus , Dendrobium spp,Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28727575/surface-energy-tunable-iso-decyl-acrylate-based-molds-for-low-pressure-nano-imprint-lithography
#9
Hyowon Tak, Dongha Tahk, Chanho Jeong, Sori Lee, Tae-Il Kim
We presented surface energy-tunable nanoscale molds for unconventional lithography. The mold is highly robust, transparent, has a minimized haze, does not contain additives, and is a non-fluorinated IDA Isodecyl acrylate (IDA) and Trimethylolpropane Triacrylate (TMPTA) based polymer. By changing the mixing ratio of the polymer components, the cross-linking density, mechanical modulus, and surface energy (crucial factors in low pressure (1~2×105 N/m2) nanoimprint lithography (LP-NIL)), can be controlled. To verify these properties of the molds, we also characterized the surface energy by measuring the contact angles and calculating the work of adhesion among the wafer, polymer film, and mold for successful demolding in nanoscale structures...
July 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28722432/benzocoumarin-hydrazine-a-large-stokes-shift-fluorogenic-sensor-for-detecting-carbonyls-in-isolated-biomolecules-and-in-live-cells
#10
Kamalika Mukherjee, Tak Ian Chio, Han Gu, Abhijit Banerjee, Anthony M Sorrentino, Dan L Sackett, Susan L Bane
Detection and quantification of biomolecule carbonylation, a critical manifestation of oxidative stress, allows better understanding of associated disease states. Existing approaches for such analyses require further processing of cells and tissues, which leads to loss of both spatial and temporal information about carbonylated biomolecules in cells. Live cell detection of these species requires sensors that are nontoxic, sufficiently reactive with the biocarbonyl in the intracellular milieu, and detectable with commonly available instrumentation...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722290/development-of-a-cardiovascular-diseases-risk-prediction-model-and-tools-for-chinese-patients-with-type-2-diabetes-mellitus-a-population-based-retrospective-cohort-study
#11
Eric Yuk Fai Wan, Daniel Yee Tak Fong, Colman Siu Cheung Fung, Esther Yee Tak Yu, Weng Yee Chin, Anca Ka Chun Chan, Cindy Lo Kuen Lam
AIMS: Evidence-based cardiovascular diseases(CVD) risk prediction models and tools specific for Chinese patients with type 2 diabetes mellitus(T2DM) are currently unavailable. This study aimed to develop and validate a CVD risk prediction model for Chinese T2DM patients. MATERIALS AND METHODS: A retrospective cohort study was conducted on 137 935 Chinese patients aged 18-79 years with T2DM and without prior history of CVD, who had received public primary care services between 1 January 2010 and 31 December 2010...
July 19, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28721901/psmb8-as-a-candidate-marker-of-responsiveness-to-preoperative-radiation-therapy-in-rectal-cancer-patients
#12
Ye Jin Ha, Ka Hee Tak, Chan Wook Kim, Seon Ae Roh, Eun Kyung Choi, Dong Hyung Cho, Jeong Hwan Kim, Seon Kyu Kim, Seon Young Kim, Yong Sung Kim, Jin Cheon Kim
PURPOSE: The ability to predict individual responsiveness to cancer therapy is urgently needed. This is particularly true for patients with locally advanced rectal cancer (LARC) because a large proportion are resistant to preoperative chemoradiation therapy (CRT). In this study, we sought to identify markers that could predict response by comparing the gene expression profiles of the tumors of patients who received preoperative CRT. METHODS AND MATERIALS: The basal gene expression profiles of tumors from 22 LARC patients who were responders (n=9) and nonresponders (n=13) to preoperative CRT were analyzed using RNA sequencing (RNA-Seq)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28715781/effects-of-blue-or-violet-light-on-the-inactivation-of-staphylococcus-aureus-by-riboflavin-5-phosphate-photolysis
#13
Tak-Wah Wong, Chien-Wei Cheng, Zong-Jhe Hsieh, Ji-Yuan Liang
The light sensitive compound riboflavin-5'-phosphate (or flavin mononucleotide, FMN) generates reactive oxygen species (ROS) upon photo-irradiation. FMN is required by all flavoproteins because it is a cofactor of biological blue-light receptors. The photochemical effects of FMN after irradiation by blue or violet light on the inactivation of Staphylococcus aureus strains, including a methicillin-resistant strain (MRSA), were investigated in this study. Upon blue- or violet-light photo-treatment, FMN was shown to inactivate S...
July 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28715603/an-exploratory-study-on-exemplary-practice-of-nurse-consultants
#14
Frances Kam Yuet Wong, Ada Tak Yin Lau, Rebecca Ng, Elaine Wing Yee Wong, So Man Wong, Eva Ching Yee Kan, Eva Liu, Denise Bryant-Lukosius
PURPOSE: To examine the exemplary practice of nurse consultants (NCs) and derive a model to illustrate the highest level of advanced nursing practice. DESIGN: A descriptive study was conducted to examine the practice and outcomes of seven NC roles in varied clinical specialties in Hong Kong. Exemplary practice was examined in relation to competencies for advanced practice nursing in Hong Kong and the United Kingdom. METHODS: Data about NC characteristics and their practices were collected using a structured questionnaire and analyzed using descriptive statistics...
July 17, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28715178/flexible-and-robust-superomniphobic-surfaces-created-by-localized-photofluidization-of-azopolymer-pillars
#15
Jaeho Choi, Wonhee Jo, Seung Yeol Lee, Yeon Sik Jung, Shin-Hyun Kim, Hee-Tak Kim
Springtails, insects which breathe through their skins, possess mushroom-shaped nanostructures. As doubly re-entrant geometry in the mushroom head enhances the resistance against liquid invasion, the springtails have robust, liquid-free omniphobic skins. Although omniphobic surfaces are promising for various applications, it remains an important challenge to mimic the structural feature of springtails. This paper presents a pragmatic method to create doubly re-entrant nanostructures and robust superomniphobic surfaces by exploiting localized photofluidization of azopolymers...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28714001/lps-enhances-tlr4-expression-and-ifn%C3%A2-%C3%AE-production-via-the-tlr4-irak-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-rat-pulmonary-arterial-smooth-muscle-cells
#16
Pengyan Wang, Xuhui Han, Biwen Mo, Guojin Huang, Changming Wang
The aim of the present study was to investigate the role of the Toll‑like receptor (TLR)4 signaling pathway in cellular response to lipopolysaccharide (LPS) in rat pulmonary artery smooth muscle cells (PASMCs). Chronic obstructive pulmonary disease (COPD) rats were established with passive inhaling cigarette smoke plus injection of LPS. The TLR4 protein in lung tissues was determined with immunohistochemical staining and protein levels of the components of the TLR4 pathway in PASMCs were analyzed with western blotting...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28712390/-the-oxldl-%C3%AE-2gpi-%C3%AE-2gpi-ab-complex-promotes-the-migration-and-the-expression-of-inflammatory-cytokines-in-human-umbilical-vein-endothelial-cells
#17
Qianqian Cai, Hong Zhou, Guiting Zhang, Chao He, Xiaojie Zhu, Xiaoyan Wang, Hang Ouyang
Objective To study the effects of the complex of oxidized low density lipoprotein/β2-glycoprotein I/β2-glycoprotein I antibodies (oxLDL/β2GPI/β2GPI-Ab) on the migration of human umbilical vein endothelial cells (HUVECs) and the expression of inflammatory cytokines, and their underlying Toll-like receptor (TLR4) pathway. Methods HUVECs were treated with oxLDL, oxLDL/β2GPI complex, oxLDL/β2GPI-Ab complex, oxLDL/β2GPI/β2GPI-Ab complex, or lipopolysaccharide (LPS) for a period of time in their corresponding groups...
July 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28704557/monte-carlo-studies-on-neutron-interactions-in-radiobiological-experiments
#18
Mehrdad Shahmohammadi Beni, Tak Cheong Hau, D Krstic, D Nikezic, K N Yu
Monte Carlo method was used to study the characteristics of neutron interactions with cells underneath a water medium layer with varying thickness. The following results were obtained. (1) The fractions of neutron interaction with 1H, 12C, 14N and 16O nuclei in the cell layer were studied. The fraction with 1H increased with increasing medium thickness, while decreased for 12C, 14N and 16O nuclei. The bulges in the interaction fractions with 12C, 14N and 16O nuclei were explained by the resonance spikes in the interaction cross-section data...
2017: PloS One
https://www.readbyqxmd.com/read/28703301/the-xenoestrogens-biphenol-a-and-nonylphenol-differentially-regulate-metalloprotease-mediated-shedding-of-egfr-ligands
#19
Paulina Urriola-Muñoz, Xue Li, Thorsten Maretzky, David R McIlwain, Tak W Mak, Juan G Reyes, Carl P Blobel, Ricardo D Moreno
The xenoestrogens Bisphenol-A (BPA) and Nonylphenol (NP) are endocrine disruptors used in the plastic polymer industry to manufacture different products for human use. Previous studies have suggested a role of these compounds in the shedding of signaling molecules, such as tumor necrosis factor α (TNF- α). The aim of this work was to evaluate the effect of BPA and NP on the sheddase ADAM17 and its newly discovered regulators iRhom1 and iRhom2 in the release of EGFR-ligands. We report that BPA and NP can stimulate the release of the ADAM17-substrates HB-EGF and TGF- α...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28702199/prevalence-of-methicillin-resistance-and-macrolide-lincosamide-streptogramin-b-resistance-in-staphylococcus-haemolyticus-among-clinical-strains-at-a-tertiary-care-hospital-in-thailand
#20
S Teeraputon, P Santanirand, T Wongchai, W Songjang, N Lapsomthob, D Jaikrasun, S Toonkaew, P Tophon
Staphylococcus spp. is a major cause of nosocomial infection and sepsis. However, increasing drug resistance is becoming a challenge to microbiologists. The purpose of this study was to identify and determine antimicrobial resistance phenotypes and drug resistance genes of clinical coagulase-negative staphylococci (CoNS) isolates at Mae Sot Hospital in Tak province, Thailand. A total of 229 CoNS isolates were collected from clinical specimens during two periods in 2014 and in 2015. Staphylococcus haemolyticus was the most prevalent species (37...
September 2017: New Microbes and New Infections
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