keyword
MENU ▼
Read by QxMD icon Read
search

TAK

keyword
https://www.readbyqxmd.com/read/28339435/impact-of-celiac-plexus-neurolysis-on-survival-in-patients-with-unresectable-pancreatic-cancer-a-retrospective-propensity-score-matching-analysis
#1
Tak Kyu Oh, Woo Jin Lee, Sang Myung Woo, Nam Woo Kim, Jiyeon Yim, Dae Hyun Kim
BACKGROUND: Pain caused by pancreatic cancer (PC) is difficult to control. Celiac plexus neurolysis (CPN) can effectively control the pain and reduce the use of opioids. However, the effect of CPN on survival for patients with unresectable PC remains controversial. OBJECTIVES: To determine if CPN is associated with survival benefits for these patients. STUDY DESIGN: Retrospective, observational cohort study. SETTING: National Cancer Center in Korea...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339357/development-of-a-score-for-assessment-of-radiologic-damage-in-large-vessel-vasculitis-combined-arteritis-damage-score-cards
#2
Daiki Nakagomi, Claire Cousins, Jan Sznajd, Shunsuke Furuta, Aladdin J Mohammad, Raashid Luqmani, David Jayne
OBJECTIVES: Outcome assessment in large-vessel vasculitis (LVV) remains challenging and this impairs patient management and the conduct of clinical studies. Previous proposals for outcome tools have not included imaging. This study aimed to develop an imaging score to quantify damage in LVV and to assess the difference between Takayasu (TAK) and giant cell arteritis (GCA). METHODS: Ninety-six patients (41 TAK, 55 GCA) were identified from local registries at two University Hospitals in the UK...
March 13, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28334016/does-shoe-heel-design-influence-ground-reaction-forces-and-knee-moments-during-maximum-lunges-in-elite-and-intermediate-badminton-players
#3
Wing-Kai Lam, Jaejin Ryue, Ki-Kwang Lee, Sang-Kyoon Park, Jason Tak-Man Cheung, Jiseon Ryu
BACKGROUND: Lunge is one frequently executed movement in badminton and involves a unique sagittal footstrike angle of more than 40 degrees at initial ground contact compared with other manoeuvres. This study examined if the shoe heel curvature design of a badminton shoe would influence shoe-ground kinematics, ground reaction forces, and knee moments during lunge. METHODS: Eleven elite and fifteen intermediate players performed five left-forward maximum lunge trials with Rounded Heel Shoe (RHS), Flattened Heel Shoe (FHS), and Standard Heel Shoes (SHS)...
2017: PloS One
https://www.readbyqxmd.com/read/28332358/perceptions-of-postmenopausal-symptoms-and-treatment-options-among-middle-aged-korean-women
#4
Min Kyoung Kim, Seok Kyo Seo, Hee Dong Chae, Kyung Joo Hwang, Tak Kim, Byung Koo Yoon, Byung Seok Lee
PURPOSE: To investigate the perceptions of postmenopausal symptoms and treatment options among middle-aged Korean women. MATERIALS AND METHODS: This cross-sectional study included 2330 Korean women. The women were administered a structured questionnaire to collect sociodemographic data and information regarding menopause and its treatment. RESULTS: More than half (65%) of the participants perceived menopause as a disease, and 66.8% knew hormone therapy (HT) is available for menopausal symptom treatment...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28330511/cytochrome-c-oxidase-subunit-i-haplotype-reveals-high-genetic-diversity-of-angiostrongylus-malaysiensis-nematoda-angiostrongylidae
#5
P Eamsobhana, H S Yong, S L Song, A Prasartvit, S Boonyong, A Tungtrongchitr
The rat lungworm Angiostrongylus malaysiensis is a metastrongyloid nematode parasite. It has been reported in Malaysia, Thailand, Laos, Myanmar, Indonesia and Japan. In this study, A. malaysiensis adult worms recovered from the lungs of wild rats in different geographical regions/provinces in Thailand were used to determine their haplotype by means of the mitochondrial partial cytochrome c oxidase subunit I (COI) gene sequence. The results revealed high COI haplotype diversity of A. malaysiensis from Thailand...
March 23, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28323620/discovery-of-novel-determinants-of-endothelial-lineage-using-chimeric-heterokaryons
#6
Wing Tak Wong, Gianfranco Matrone, XiaoYu Tian, Simion Alin Tomoiaga, Kin Fai Au, Shu Meng, Sayumi Yamazoe, Daniel Sieveking, Kaifu Chen, David M Burns, James K Chen, Helen M Blau, John P Cooke
We wish to identify determinants of endothelial lineage. Murine embryonic stem cells (mESC) were fused with human endothelial cells in stable, non-dividing, heterokaryons. Using RNA-seq it is possible to discriminate between human and mouse transcripts in these chimeric heterokaryons. We observed a temporal pattern of gene expression in the ESCs of the heterokaryons that recapitulated ontogeny, with early mesodermal factors being expressed before mature endothelial genes. A set of transcriptional factors not known to be involved in endothelial development was upregulated, one of which was POU class 3 homeobox 2 (Pou3f2)...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28322697/molecular-identification-of-spirometra-erinaceieuropaei-tapeworm-in-cases-of-human-sparganosis-hong-kong
#7
Tommy H C Tang, Samson S Y Wong, Christopher K C Lai, Rosana W S Poon, Helen S Y Chan, Tak Chiu Wu, Yuk-Fai Cheung, Tak-Lap Poon, Yi-Po Tsang, Wai-Lun Tang, Alan K L Wu
Human sparganosis is a foodborne zoonosis endemic in Asia. We report a series of 9 histologically confirmed human sparganosis cases in Hong Kong, China. All parasites were retrospectively identified as Spirometra erinaceieuropaei. Skin and soft tissue swelling was the most common symptom, followed by central nervous system lesions.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28321219/computational-model-reveals-limited-correlation-between-germinal-center-b-cell-subclone-abundancy-and-affinity-implications-for-repertoire-sequencing
#8
Polina Reshetova, Barbera D C van Schaik, Paul L Klarenbeek, Marieke E Doorenspleet, Rebecca E E Esveldt, Paul-Peter Tak, Jeroen E J Guikema, Niek de Vries, Antoine H C van Kampen
Immunoglobulin repertoire sequencing has successfully been applied to identify expanded antigen-activated B-cell clones that play a role in the pathogenesis of immune disorders. One challenge is the selection of the Ag-specific B cells from the measured repertoire for downstream analyses. A general feature of an immune response is the expansion of specific clones resulting in a set of subclones with common ancestry varying in abundance and in the number of acquired somatic mutations. The expanded subclones are expected to have BCR affinities for the Ag higher than the affinities of the naive B cells in the background population...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28320333/delta-neutrophil-index-is-an-independent-predictor-of-mortality-in-septic-acute-kidney-injury-patients-treated-with-continuous-renal-replacement-therapy
#9
In Mi Han, Chang-Yun Yoon, Dong Ho Shin, Youn Kyung Kee, Seung Gyu Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
BACKGROUND: Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT). METHOD: This is a retrospective analysis of consecutively CRRT treated patients...
March 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28319160/psychometric-assessment-of-the-chinese-version-of-the-brief-illness-perception-questionnaire-in-breast-cancer-survivors
#10
Na Zhang, Richard Fielding, Inda Soong, Karen K K Chan, Conrad Lee, Alice Ng, Wing Kin Sze, Janice Tsang, Victor Lee, Wendy Wing Tak Lam
OBJECTIVE: The eight-item Brief Illness Perception Questionnaire (B-IPQ) supposedly evaluates cognitive and emotional representations of illness. This study examined the validity and reliability of a traditional Chinese version of the B-IPQ in Hong Kong Chinese breast cancer survivors. METHODS: 358 Chinese breast cancer survivors who had recently ended their primary treatment completed this B-IPQ Chinese version. Confirmatory factor analysis (CFA) tested the factor structure...
2017: PloS One
https://www.readbyqxmd.com/read/28318904/dual-memory-neural-networks-for-modeling-cognitive-activities-of-humans-via-wearable-sensors
#11
Sang-Woo Lee, Chung-Yeon Lee, Dong-Hyun Kwak, Jung-Woo Ha, Jeonghee Kim, Byoung-Tak Zhang
Wearable devices, such as smart glasses and watches, allow for continuous recording of everyday life in a real world over an extended period of time or lifelong. This possibility helps better understand the cognitive behavior of humans in real life as well as build human-aware intelligent agents for practical purposes. However, modeling the human cognitive activity from wearable-sensor data stream is challenging because learning new information often results in loss of previously acquired information, causing a problem known as catastrophic forgetting...
February 20, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28318829/toll-like-receptor-4-inhibitor-protects-against-retinal-ganglion-cell-damage-induced-by-optic-nerve-crush-in-mice
#12
Yukimichi Nakano, Masamitsu Shimazawa, Kazuki Ojino, Hiroshi Izawa, Hiroto Takeuchi, Yuki Inoue, Kazuhiro Tsuruma, Hideaki Hara
Toll-like receptor 4 (TLR4) plays key roles in innate immune responses and inflammatory reactions. TAK-242 (resatorvid) is a small-molecule cyclohexene derivative that selectively inhibits TLR4 signaling pathways and suppresses inflammatory reactions. Here we investigated the protective effects of TAK-242 against optic nerve crush (ONC) which induces axonal injury like glaucoma in mice. TAK-242 was injected intravitreally immediately after ONC. The effect of TAK-242 was evaluated by measuring the number of fluorogold-labeled retinal ganglion cells (RGCs) at 10 days after ONC...
March 2, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28314562/intermittent-vibration-protects-aged-muscle-from-mechanical-and-oxidative-damage-under-prolonged-compression
#13
Sing Wan Wong, Brian Chun Ho Cheung, Bruce Tak Keung Pang, Ateline Kwong, Anna Chung, Kenneth Ka Ho Lee, Arthur Fut Tak Mak
Deep tissue pressure ulcers, a serious clinical challenge originating in the muscle layer, are hardly detectable at the beginning. The challenge apparently occurs in aged subjects more frequently. As the ulcer propagates to the skin surface, it becomes very difficult to manage and can lead to fatal complications. Preventive measures are thus highly desirable. Although the complex pathological mechanisms have not been fully understood, prolonged and excessive physical challenges and oxidative stress are believed to be involved in the ulcer development...
February 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28303957/astragalus-polysaccharides-exerts-immunomodulatory-effects-via-tlr4-mediated-myd88-dependent-signaling-pathway-in-vitro-and-in-vivo
#14
Lijing Zhou, Zijing Liu, Zhixue Wang, Shuang Yu, Tingting Long, Xing Zhou, Yixi Bao
Astragalus polysaccharides (APS), which is widely used as a remedy to promote immunity of breast cancer patients, can enhance immune responses and exert anti-tumor effects. In this study, we investigated the effects and mechanisms of APS on macrophage RAW 264.7 and EAC tumor-bearing mice. Griess reaction and ELISA assays revealed that the concentrations of nitric oxide, TNF-α, IL-1β and IL-6 were increased by APS. However, this effect was diminished in the presence of TAK-242 (TLR4 inhibitor) or ST-2825(MyD88 inhibitor)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302140/nighttime-eating-and-breast-cancer-among-chinese-women-in-hong-kong
#15
Mengjie Li, Lap Ah Tse, Wing-Cheong Chan, Chi-Hei Kwok, Siu-Lan Leung, Cherry Wu, Wai-Cho Yu, Priscilla Ming-Yi Lee, Koon-Ho Tsang, Sze-Hong Law, Roel Vermeulen, Fangyi Gu, Neil E Caporaso, Ignatius Tak-Sun Yu, Feng Wang, Xiaohong Rose Yang
BACKGROUND: A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits after 10 p.m. and breast cancer in Hong Kong women. METHODS: A hospital-based case-control study was conducted during 2012-2015. A total of 922 patients with incident breast cancer (cases) and 913 hospital controls were recruited and interviewed using a standard questionnaire including information on eating behavior during both daytime and nighttime...
March 17, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28299924/improvement-of-electrical-characteristics-and-stability-of-amorphous-indium-gallium-zinc-oxide-thin-film-transistors-using-nitrocellulose-passivation-layer
#16
Kwan Yup Shin, Young Jun Tak, Won-Gi Kim, Seonghwan Hong, Hyun Jae Kim
In this research, nitrocellulose is proposed as a new material for the passivation layers of amorphous indium gallium zinc oxide thin film transistors (a-IGZO TFTs). The a-IGZO TFTs with nitrocellulose passivation layers (NC-PVLs) demonstrate improved electrical characteristics and stability. The a-IGZO TFTs with NC-PVLs exhibit improvements in field-effect mobility (μFE) from 11.72 ± 1.14 to 20.68 ± 1.94 cm2/Vs, threshold voltage (Vth) from 1.85 ± 1.19 to 0.56 ± 0.35 V, and on/off current ratio (Ion/off) from (5...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28291959/the-opening-of-atp-sensitive-k-channels-protects-h9c2-cardiac-cells-against-the-high-glucose-induced-injury-and-inflammation-by-inhibiting-the-ros-tlr4-necroptosis-pathway
#17
Weijie Liang, Meiji Chen, Dongdan Zheng, Jianhao Li, Mingcai Song, Wenzhu Zhang, Jianqiang Feng, Jun Lan
BACKGROUND/AIMS: Hyperglycemia activates multiple signaling molecules, including reactive oxygen species (ROS), toll-like receptor 4 (TLR4), receptor-interacting protein 3 (RIP3, a kinase promoting necroptosis), which mediate hyperglycemia-induced cardiac injury. This study explored whether inhibition of ROS-TLR4-necroptosis pathway contributed to the protection of ATP-sensitive K+ (KATP) channel opening against high glucose-induced cardiac injury and inflammation. METHODS: H9c2 cardiac cells were treated with 35 mM glucose (HG) to establish a model of HG-induced insults...
February 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28287803/benefit-finding-and-effect-on-caregiver-depression-a-double-blind-randomized-controlled-trial
#18
Sheung-Tak Cheng, Emily P M Mak, Helene H Fung, Timothy Kwok, Diana T F Lee, Linda C W Lam
OBJECTIVE: To examine the effects of using cognitive reappraisal to find positive gains on caregivers' depressive symptoms, burden, and psychological well-being. METHOD: Ninety-six caregivers of persons with Alzheimer's disease were randomly assigned to receive a benefit-finding intervention or 1 of 2 treatment-as-usual conditions, namely, simplified psychoeducation (lectures only; SIM-PE) or standard psychoeducation (STD-PE). Each participant received 4 biweekly interventions of 3 hr each, over a 2-month period, at home...
March 13, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28287578/modeling-ovarian-cancer-multicellular-spheroid-behavior-in-a-dynamic-3d-peritoneal-microdevice
#19
Shan-Shan Li, Carman K M Ip, Matthew Y H Tang, Samuel K H Sy, Susan Yung, Tak-Mao Chan, Mengsu Yang, Ho Cheung Shum, Alice S T Wong
Ovarian cancer is characterized by extensive peritoneal metastasis, with tumor spheres commonly found in the malignant ascites. This is associated with poor clinical outcomes and currently lacks effective treatment. Both the three-dimensional (3D) environment and the dynamic mechanical forces are very important factors in this metastatic cascade. However, traditional cell cultures fail to recapitulate this natural tumor microenvironment. Thus, in vivo-like models that can emulate the intraperitoneal environment are of obvious importance...
February 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28280050/single-stranded-dna-library-preparation-preferentially-enriches-short-maternal-dna-in-maternal-plasma
#20
Joaquim S L Vong, Jason C H Tsang, Peiyong Jiang, Wing-Shan Lee, Tak Yeung Leung, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo
BACKGROUND: Recent studies have suggested that single-stranded DNA (ssDNA) library preparation can enrich short DNA species from the plasma of healthy individuals, cancer patients, and transplant recipients. Based on previous observations that fetal DNA molecules in the maternal plasma are shorter than maternal DNA molecules, ssDNA library preparation may potentially enrich fetal DNA and provide substantial improvement in noninvasive prenatal testing. METHODS: We tested this hypothesis by comparing the maternal plasma DNA sequencing results using 2 types of ssDNA library preparation methods and a standard double-stranded DNA (dsDNA) library method using samples from first- and third-trimester pregnancies...
March 9, 2017: Clinical Chemistry
keyword
keyword
41770
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"