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https://www.readbyqxmd.com/read/29337841/frequency-and-severity-of-acute-allergic-like-reactions-to-intravenously-administered-gadolinium-based-contrast-media-in-children
#1
Monica M Forbes-Amrhein, Jonathan R Dillman, Andrew T Trout, Bernadette L Koch, Julie M Dickerson, Richard M Giordano, Alexander J Towbin
OBJECTIVES: The purpose of this study is to determine the frequency and severity of acute allergic-like reactions to gadolinium-based contrast media (GBCM) in children before, during, and after the transition from gadopentetate dimeglumine to gadoterate meglumine as our primary clinical GBCM. MATERIALS AND METHODS: Institutional review board approval was obtained for this Health Insurance Portability and Accountability Act-compliant retrospective investigation. Allergic-like reactions to GBCM in pediatric patients were retrospectively assessed from January 2009 to January 2017, which included a departmental change of GBCM from gadopentetate dimeglumine to gadoterate meglumine...
January 15, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29335868/added-value-of-ancillary-imaging-features-for-differentiating-scirrhous-hepatocellular-carcinoma-from-intrahepatic-cholangiocarcinoma-on-gadoxetic-acid-enhanced-mr-imaging
#2
Seo-Youn Choi, Young Kon Kim, Ji Hye Min, Tae Wook Kang, Woo Kyoung Jeong, Soohyun Ahn, Hojeong Won
OBJECTIVES: To determine ancillary features that help distinguish between scirrhous hepatocellular carcinoma (S-HCC) and intrahepatic cholangiocarcinoma (ICC) and investigate added value of ancillary features to enhancement pattern-based diagnosis on gadoxetic acid-enhanced MRI. METHODS: This retrospective study included 96 patients with S-HCCs and 120 patients with ICCs who underwent gadoxetic acid MRI before surgical resection. Two observers reviewed MRIs of the tumours...
January 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#3
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29260280/peri-tumoral-hyperintensity-on-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-in-hepatocellular-carcinomas-correlation-with-peri-tumoral-hyperplasia-and-its-pathological-features
#4
Norihide Yoneda, Osamu Matsui, Azusa Kitao, Takahiro Komori, Kazuto Kozaka, Hiroko Ikeda, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Satoshi Kobayashi, Toshifumi Gabata
PURPOSE: Peri-tumoral hyperintensity (P-hyperintensity) is occasionally seen in hepatocellular carcinoma (HCC) on the hepatobiliary (HB) phase of gadoxetic acid-enhanced MRI (EOB-MRI). A recent study reported peri-tumoral hyperplasia (P-hyperplasia) associated with over-expression of glutamine synthetase (GS) in HCC or metastatic carcinoma. The aim of this study was to analyze the correlation between P-hyperintensity on the HB phase and GS expression indicating P-hyperplasia and reveal its pathological features...
December 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29246586/diagnostic-per-lesion-performance-of-a-simulated-gadoxetate-disodium-enhanced-abbreviated-mri-protocol-for-hepatocellular-carcinoma-screening
#5
B G Tillman, J D Gorman, J M Hru, M H Lee, M C King, C B Sirlin, R M Marks
AIM: To evaluate the diagnostic per-lesion performance of a simulated gadoxetate disodium-enhanced abbreviated MRI (AMRI) in cirrhotic and chronic hepatitis B (CHB) patients for hepatocellular carcinoma (HCC) screening. MATERIALS AND METHODS: Seventy-nine consecutive patients at risk for HCC due to cirrhosis and/or CHB were included in this retrospective study. For each patient, the first gadoxetate disodium-enhanced MRI between 2008 through 2014 was analysed. Two independent readers read an anonymised abbreviated image set comprising axial T1-weighted (W) images with fat saturation in the hepatobiliary phase, 20 minutes or more after gadoxetate injection, and axial T2W single-shot fast spin echo images...
December 12, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29244853/limited-detection-of-small-%C3%A2-10-mm-colorectal-liver-metastasis-at-preoperative-ct-in-patients-undergoing-liver-resection
#6
Yousun Ko, Jihang Kim, Joseph Kyu-Hyung Park, Haeryoung Kim, Jai Young Cho, Sung-Bum Kang, Soyeon Ahn, Kyong Joon Lee, Kyoung Ho Lee
OBJECTIVE: To retrospectively determine the sensitivity of preoperative CT in the detection of small (≤ 10 mm) colorectal liver metastasis (CRLM) nodules in patients undergoing liver resection. METHODS: The institutional review board approved the study and waived informed consent. We included 461 pathologically confirmed CRLM nodules in 211 patients (including 71 women; mean age, 66.4 years) who underwent 229 liver resections following abdominal CT. Prior to 163 resections, gadoxetic acid-enhanced liver MR imaging was also performed...
2017: PloS One
https://www.readbyqxmd.com/read/29239710/liver-fibrosis-deep-convolutional-neural-network-for-staging-by-using-gadoxetic-acid-enhanced-hepatobiliary-phase-mr-images
#7
Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Osamu Abe, Shigeru Kiryu
Purpose To investigate the performance of a deep convolutional neural network (DCNN) model in the staging of liver fibrosis using gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) imaging. Materials and Methods This retrospective study included patients for whom input data (hepatobiliary phase MR images, static magnetic field of the imaging unit, and hepatitis B and C virus testing results available, either positive or negative) and reference standard data (liver fibrosis stage evaluated from biopsy or surgical specimens obtained within 6 months of the MR examinations) were available were assigned to the training (534 patients) or the test (100 patients) group...
December 14, 2017: Radiology
https://www.readbyqxmd.com/read/29235879/experimental-studies-on-artifacts-and-tumor-enhancement-on-gadoxetic-acid-enhanced-arterial-phase-liver-mri-in-a-rabbit-vx2-tumor-model
#8
Takahiro Tsuboyama, Gregor Jost, Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Hubertus Pietsch, Noriyuki Tomiyama
Background Rapid injection of gadoxetic acid is reported to produce more frequent artifacts and lower vascular enhancement on arterial phase liver magnetic resonance imaging (MRI). However, its effect on tumor enhancement and the mechanism of the artifacts remain unclear. Purpose To evaluate the effect of rapid injection of gadoxetic acid on artifacts and tumor enhancement during arterial phase liver MRI, and on arterial blood gases (ABGs) which may explain the cause of the artifacts. Material and Methods ABG analysis was performed in 13 free-breathing rabbits after rapid injection (1 mL/s; injection time = 0...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29230525/diagnostic-accuracy-of-prospective-application-of-the-liver-imaging-reporting-and-data-system-li-rads-in-gadoxetate-enhanced-mri
#9
Yeun-Yoon Kim, Chansik An, Sungwon Kim, Myeong-Jin Kim
OBJECTIVES: To evaluate the diagnostic performance of the LI-RADS (v2014) on gadoxetate-enhanced MRI prospectively applied in actual practice. METHODS: We retrospectively reviewed the prospectively written radiology reports of 143 treatment-naïve at-risk patients who underwent gadoxetate-enhanced liver MRI from January to December 2014, and identified 202 hepatic observations categorized using the LI-RADS. The diagnostic performances of LI-RADS categories for hepatocellular carcinoma (HCC) and hepatic malignancy were calculated...
December 11, 2017: European Radiology
https://www.readbyqxmd.com/read/29221964/inflammatory-hepatic-adenomas-characterization-with-hepatobiliary-mri-contrast-agents
#10
James F Glockner, Christine U Lee, Taofic Mounajjed
PURPOSE: To characterize the MRI appearance of inflammatory hepatic adenomas using hepatobiliary contrast agents. MATERIALS AND METHODS: MRI was performed using hepatobiliary contrast agents (3 with gadobenate dimeglumine and 24 with gadoxetic acid) in 27 patients with immunohistochemistry-confirmed diagnosis of inflammatory hepatic adenoma. The appearance of the lesions on T2 and diffusion-weighted images, pre-gadolinium T1-weighted images, dynamic post-gadolinium images, and hepatobiliary phase images was assessed...
December 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29193508/detection-of-liver-fibrosis-using-qualitative-and-quantitative-mr-elastography-compared-to-liver-surface-nodularity-measurement-gadoxetic-acid-uptake-and-serum-markers
#11
Cecilia Besa, Mathilde Wagner, Grace Lo, Sonja Gordic, Manjil Chatterji, Paul Kennedy, Ashley Stueck, Swan Thung, James Babb, Andrew Smith, Bachir Taouli
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) combining different techniques such as MR elastography (MRE) has emerged as a noninvasive approach to diagnose and stage liver fibrosis with high accuracy allowing for anatomical and functional information. PURPOSE: To assess the diagnostic performance of mpMRI including qualitative and quantitative assessment of MRE, liver surface nodularity (LSN) measurement, hepatic enhancement ratios postgadoxetic acid, and serum markers (APRI, FIB-4) for the detection of liver fibrosis...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29189403/how-do-different-indices-of-hepatic-enhancement-with-gadoxetic-acid-compare-in-predicting-liver-failure-and-other-major-complications-after-hepatectomy
#12
Andreu F Costa, Amélie Tremblay St-Germain, Mohamed Abdolell, Rory L Smoot, Sean Cleary, Kartik S Jhaveri
OBJECTIVE: The objective of this study was to assess the accuracy of gadoxetic acid hepatic enhancement indices in predicting posthepatectomy liver failure (PHLF) and other major complications (OMCs). METHODS: Sixty-five patients underwent prehepatectomy gadoxetic acid-enhanced magnetic resonance imaging. Enhancement indices were calculated by obtaining regions of interest on magnetic resonance images and segmented volumes of the liver and spleen. Multivariate regression analysis was performed to predict PHLF and OMC as a function of the indices, and areas under the receiver operator characteristic (AUROC) curves were calculated...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29166246/imaging-features-of-gadoxetic-acid-enhanced-and-diffusion-weighted-mr-imaging-for-identifying-cytokeratin-19-positive-hepatocellular-carcinoma-a-retrospective-observational-study
#13
Seo-Youn Choi, Seong Hyun Kim, Cheol Keun Park, Ji Hye Min, Ji Eun Lee, Yoon-Hyeong Choi, Bo Ra Lee
Purpose To determine the preoperative magnetic resonance (MR) imaging findings potentially most useful for predicting cytokeratin 19 (CK19)-positive hepatocellular carcinoma (HCC) and to evaluate the prognosis after curative resection in patients with a single HCC lesion positive for CK19 compared with patients with HCC who are negative for CK19. Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Two hundred four patients with CK19-negative HCC and 38 with CK19-positive HCC who underwent curative resection after gadoxetic acid-enhanced and diffusion-weighted MR imaging were retrospectively evaluated in a single institution...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29156475/transient-severe-respiratory-motion-artifacts-after-application-of-gadoxetate-disodium-what-we-currently-know
#14
Lennart Well, Julius Matthias Weinrich, Gerhard Adam, Peter Bannas
Background Gadoxetate disodium is an intracellular contrast agent for magnetic resonance imaging (MRI) of the liver. Recent publications revealed that injection of gadoxetate disodium can lead to imaging artifacts due to transient severe motion (TSM) in the arterial phase of contrast-enhanced liver MRI. In this review we present and discuss published frequencies of TSM, contrast injection and image acquisition protocols, potential risk factors, and proposed strategies to avoid or minimize the effects of TSM...
November 20, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29128992/mapping-of-hepatic-vasculature-in-potential-living-liver-donors-comparison-of-gadoxetic-acid-enhanced-mr-imaging-using-caipirinha-technique-with-ct-angiography
#15
Kartik Jhaveri, Lijun Guo, Luís Guimarães, Ravi Menezes, Ian McGilvray, Mark Cattral, David Grant
PURPOSE: To retrospectively evaluate gadoxetic acid-enhanced magnetic resonance angiography (MRA) using controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) technique for mapping hepatic vascular anatomy in potential living liver donors, with CT angiography (CTA) as reference standard. METHODS: 82 potential living liver donors who underwent MRA and CTA were enrolled in this HIPAA-compliant IRB-approved study. MRA and CTA images were evaluated by two reviewers in consensus with respect to (1) image quality scores for depiction of the hepatic vessels and (2) accuracy of MRA for determining the hepatic vascular variants with CTA as reference standard...
November 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29116626/unclassified-hepatocellular-adenoma-in-a-middle-aged-woman-with-glucose-intolerance
#16
Kumi Ozaki, Kenichi Harada, Toru Yamamoto, Hiroyuki Aoyagi, Yasuharu Kaizaki, Jun Yoshikawa
The patient was a 43-year-old woman with obesity (body mass index: 29.1) and glucose intolerance who was not taking oral contraceptives. An ultrasound showed a hypoechoic hepatic mass. Dynamic contrast-enhanced computed tomography revealed a lesion in segment 6 that showed homogeneous and slight-to-moderate enhancement in the arterial phase with persistent enhancement during the portal and equilibrium phases. On magnetic resonance (MR) imaging, the lesion demonstrated hyperintensity on T2- and diffusion-weighted images and hypointensity in the hepatobiliary phase of gadoxetic-acid-enhanced MR imaging...
November 7, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29111237/imaging-findings-of-primary-hepatic-angiosarcoma-on-gadoxetate-disodium-enhanced-liver-mri-comparison-with-hepatic-haemangiomas-of-similar-size
#17
B Kim, J H Byun, J H Lee, B J Park, H-J Kwon, J H Lee, S J Lee, H J Won, Y M Shin, P N Kim
AIM: To describe imaging characteristics of primary hepatic angiosarcoma on gadoxetate disodium-enhanced dynamic magnetic resonance imaging (MRI) and to determine features that differentiate angiosarcomas from similar-sized haemangiomas. MATERIALS AND METHODS: The study included 15 patients with hepatic angiosarcomas and 35 patients with size-matched hepatic haemangiomas who underwent gadoxetate disodium-enhanced liver MRI. The number, size, growth pattern, signal intensity (SI) characteristics, and SI changes on dynamic scans were evaluated and compared between the two entities...
October 27, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29097910/analytical-interference-by-contrast-agents-in-biochemical-assays
#18
Sigrid Otnes, Niels Fogh-Andersen, Janne Rømsing, Henrik S Thomsen
Objective: To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods: The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29091004/performing-gadoxetic-acid-enhanced-mri-after-ct-for-guiding-curative-treatment-of-early-stage-hepatocellular-carcinoma-a-cost-effectiveness-analysis
#19
Chong Hyun Suh, Kyung Won Kim, Seong Ho Park, So Yeon Kim, Dong-Cheol Woo, Sangjin Shin, Junhee Pyo, Atul B Shinagare, Nikhil H Ramaiya, Young-Suk Lim
OBJECTIVE: We determined the cost-effectiveness of two different diagnostic imaging strategies in guiding curative treatment of early-stage hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We developed a decision analytic model using as its starting point a cohort of patients aged 55 years with early-stage HCC detected at dynamic multiphasic CT and with Child-Pugh class A cirrhosis. The model compared two strategies on the initial workup: conventional CT strategy using dynamic multiphasic CT only and gadoxetic acid-enhanced MRI strategy using additional gadoxetic acid-enhanced MRI after initial CT...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29084013/ring-like-enhancement-of-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-multiphasic-hepatic-arterial-phase-imaging-with-differential-subsampling-with-cartesian-ordering
#20
Shintaro Ichikawa, Utaroh Motosugi, Naoki Oishi, Tatsuya Shimizu, Tetsuya Wakayama, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate the efficacy of multiphasic hepatic arterial phase (HAP) imaging using DISCO (differential subsampling with Cartesian ordering) in increasing the confidence of diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and the requirement for informed patient consent was waived. Consecutive patients (from 2 study periods) with malignant liver nodules were examined by gadoxetic acid-enhanced magnetic resonance imaging using either multiphasic (6 phases; n = 135) or single (n = 230) HAP imaging, which revealed 519 liver nodules other than benign ones (HCC, 497; cholangiocarcinoma, 11; metastases, 10; and malignant lymphoma, 1)...
October 27, 2017: Investigative Radiology
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