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https://www.readbyqxmd.com/read/29775791/an-imaging-biomarker-for-assessing-hepatic-function-in-patients-with-primary-sclerosing-cholangitis
#1
Jennifer Schulze, Henrike Lenzen, Jan B Hinrichs, Burckhardt Ringe, Michael P Manns, Frank Wacker, Kristina I Ringe
BACKGROUND & AIMS: We aimed to evaluate the potential of hepatobiliary phase magnetic resonance imaging (MRI) as parameter for assessment of hepatocellular function in patients with primary sclerosing cholangitis (PSC). METHODS: We collected data from 111 patients (83 male, 28 female; median, 44 years old), from March 2012 through March 2016, with a confirmed diagnosis of PSC who underwent MRI evaluation before and after injection (hepatobiliary phase) of a hepatocyte-specific contrast agent (gadoxetate disodium)...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29771932/a-multi-center-preclinical-study-of-gadoxetate-dce-mri-in-rats-as-a-biomarker-of-drug-induced-inhibition-of-liver-transporter-function
#2
Anastassia Karageorgis, Stephen C Lenhard, Brittany Yerby, Mikael F Forsgren, Serguei Liachenko, Edvin Johansson, Mark A Pilling, Richard A Peterson, Xi Yang, Dominic P Williams, Sharon E Ungersma, Ryan E Morgan, Kim L R Brouwer, Beat M Jucker, Paul D Hockings
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), combined with pharmacokinetic modelling, to measure hepatobiliary transporter function in vivo in rats. The sensitivity and robustness of the method was tested by evaluating the effect of a clinical dose of the antibiotic rifampicin in four different preclinical imaging centers...
2018: PloS One
https://www.readbyqxmd.com/read/29771727/modeling-gadoxetate-liver-uptake-and-efflux-using-dynamic-contrast-enhanced-magnetic-resonance-imaging-enables-preclinical-quantification-of-transporter-drug-drug-interactions
#3
Leonidas Georgiou, Jeffrey Penny, Glynis Nicholls, Neil Woodhouse, François-Xavier Blé, Josephine H Naish, Penny L Hubbard Cristinacce
OBJECTIVES: The aim of this study was to model the in vivo transporter-mediated uptake and efflux of the hepatobiliary contrast agent gadoxetate in the liver. The efficacy of the proposed technique was assessed for its ability to provide quantitative insights into drug-drug interactions (DDIs), using rifampicin as inhibitor. MATERIALS AND METHODS: Three groups of C57 mice were scanned twice with a dynamic gadoxetate-enhanced magnetic resonance imaging protocol, using a 3-dimensional spoiled gradient-echo sequence for approximately 72 minutes...
May 15, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29767320/post-hepatectomy-liver-failure-after-major-hepatic-surgery-not-only-size-matters
#4
Ulrika Asenbaum, Klaus Kaczirek, Ahmed Ba-Ssalamah, Helmut Ringl, Christoph Schwarz, Fredrik Waneck, Fabian Fitschek, Christian Loewe, Richard Nolz
OBJECTIVES: To compare the value of functional future liver remnant (functFLR) to established clinical and imaging variables in prediction of post-hepatectomy liver failure (PHLF) after major liver resection. METHODS: This retrospective, cross-sectional study included 62 patients, who underwent gadoxetic acid enhanced MRI and MDCT within 10 weeks prior to resection of ≥ 4 liver segments. Future liver remnant (FLR) was measured in MDCT using semi-automatic software...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29735443/-differential-diagnosis-of-hepatocellular-carcinoma-and-hepatic-hemangiomas-based-on-radiomic-features-of-gadoxetate-disodium-enhanced-magnetic-resonance-imaging
#5
Mao-Dong Chen, Jing Zhang, Gui-Xiang Yang, Jie-Min Lin, Yan-Qiu Feng
OBJECTIVE: To evaluate the feasibility of using radiomic features for differential diagnosis of hepatocellular carcinoma (HCC) and hepatic cavernous hemangioma (HHE). METHODS: Gadoxetate disodium-enhanced magnetic resonance imaging data were collected from a total of 135 HCC and HHE lesions. The radiomic texture features of each lesion were extracted on the hepatobiliary phase images, and the performance of each feature was assessed in differentiation and classification of HCC and HHE...
April 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29709031/gadoxetic-acid-enhanced-magnetic-resonance-imaging-to-predict-paritaprevir-induced-hyperbilirubinemia-during-treatment-of-hepatitis-c
#6
Hironao Okubo, Hitoshi Ando, Yushi Sorin, Eisuke Nakadera, Hiroo Fukada, Junichi Morishige, Akihisa Miyazaki, Kenichi Ikejima
BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin. Hyperbilirubinemia is an adverse event reported during hepatitis C treatment. Gadoxetic acid is also transported by OATP1B1/1B3. We evaluated whether the enhancement effect in gadoxetic acid-enhanced magnetic resonance (MR) imaging could predict the plasma concentration of paritaprevir and might anticipate the development of hyperbilirubinemia. METHODS: This prospective study evaluated 27 patients with hepatitis C who underwent gadoxetic acid-enhanced MR imaging prior to treatment with ombitasvir, paritaprevir, and ritonavir...
2018: PloS One
https://www.readbyqxmd.com/read/29708786/differentiation-between-hepatocellular-carcinoma-showing-hyperintensity-on-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-and-focal-nodular-hyperplasia-by-ct-and-mri
#7
Azusa Kitao, Osamu Matsui, Norihide Yoneda, Ryuichi Kita, Kazuto Kozaka, Satoshi Kobayashi, Toshifumi Gabata
OBJECTIVE: The purpose of this study is to identify points useful in the imaging differentiation of hepatocellular carcinoma (HCC) showing hyperintensity on the hepatobiliary phase of gadoxetic acid-enhanced MRI and focal nodular hyperplasia (FNH) and FNH-like nodules. MATERIALS AND METHODS: We enrolled consecutive 51 pathologically diagnosed HCCs that were hyperintense on hepatobiliary phase imaging (47 patients, including 44 with cirrhosis) and 10 FNHs and eight FNH-like nodules (16 patients, including five with cirrhosis)...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29704934/liver-enhancement-in-healthy-dogs-after-gadoxetic-acid-administration-during-dynamic-contrast-enhanced-magnetic-resonance-imaging
#8
P Borusewicz, E Stańczyk, K Kubiak, J Spużak, K Glińska-Suchocka, M Jankowski, J Nicpoń, P Podgórski
Dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI) consists of acquisition of native baseline images, followed by a series of acquisitions performed during and after administration of a contrast medium. DCE-MRI, in conjunction with hepatobiliary-specific contrast media, such as gadoxetic acid (GD-EOB-DTPA), allows for precise characterisation of the enhancement pattern of the hepatic parenchyma following administration of the contrast agent. The aim of the study was to assess the pattern of temporal resolution contrast enhancement of the hepatic parenchyma following administration of GD-EOB-DTPA and to determine the optimal time window for post-contrast assessment of the liver...
May 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29695578/cdna-microarray-analysis-and-influx-transporter-oatp1b1-in-liver-cells-after-exposure-to-gadoxetate-disodium-a-gadolinium-based-contrast-agent-in-mri-liver-imaging
#9
Chi-Cheng Lu, Wen-Kang Chen, Jo-Hua Chiang, Yuh-Feng Tsai, Yu-Ning Juan, Ping-Chin Lin, Yeu-Sheng Tyan, Jai-Sing Yang
BACKGROUND/AIM: Gadoxetate disodium (Primovist or Eovist) is extensively used as a hepatospecific contrast agent during magnetic resonance imaging (MRI) examinations. However, there is no information determining whether gadoxetate disodium has a cytotoxic impact and/or affects relative gene expression on liver cells. In the current study, we investigated the effects of gadoxetate disodium on cytotoxicity and the levels of gene expression in human normal Chang Liver cells. MATERIALS AND METHODS: The cytotoxic effect was detected via methyl thiazolyl tetrazolium (MTT) assay and 4',6-diamidino-2-phenylindole (DAPI) staining...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29691635/clinical-impact-of-preoperative-liver-mri-in-the-evaluation-of-synchronous-liver-metastasis-of-colon-cancer
#10
Cherry Kim, So Yeon Kim, Min-Ju Kim, Yong Sik Yoon, Chan Wook Kim, Jae Hoon Lee, Kyu-Pyo Kim, Seung Soo Lee, Seong Ho Park, Moon-Gyu Lee
OBJECTIVES: To investigate whether additional MRI including gadoxetic acid enhancement is associated with survival rate (SR) in patients with synchronous liver metastasis of colon cancer (sCLM), compared with patients assessed only with CT. METHODS: Fifty-two patients underwent only CT (CT group) and 65 underwent additional MRI (CT+MRI group) for preoperative work-up of sCLM. In the CT+MRI group, the discrepancy between CT and MRI was analyzed. The 5-year SR was compared between the groups, and affecting factors were investigated...
April 24, 2018: European Radiology
https://www.readbyqxmd.com/read/29675932/quantification-of-liver-function-by-linearization-of-a-two-compartment-model-of-gadoxetic-acid-uptake-using-dynamic-contrast-enhanced-magnetic-resonance-imaging
#11
Josiah Simeth, Adam Johansson, Dawn Owen, Kyle Cuneo, Michelle Mierzwa, Mary Feng, Theodore S Lawrence, Yue Cao
Dynamic gadoxetic acid-enhanced magnetic resonance imaging (MRI) allows the investigation of liver function through the observation of the perfusion and uptake of contrast agent in the parenchyma. Voxel-by-voxel quantification of the contrast uptake rate (k1 ) from dynamic gadoxetic acid-enhanced MRI through the standard dual-input, two-compartment model could be susceptible to overfitting of variance in the data. The aim of this study was to develop a linearized, but more robust, model. To evaluate the estimated k1 values using this linearized analysis, high-temporal-resolution gadoxetic acid-enhanced MRI scans were obtained in 13 examinations, and k1 maps were created using both models...
April 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29666951/predicting-chemotherapeutic-response-for-colorectal-liver-metastases-using-relative-tumor-enhancement-of-gadoxetic-acid-disodium-enhanced-magnetic-resonance-imaging
#12
Shinichi Murata, Shigeru Matsushima, Yozo Sato, Hidekazu Yamaura, Mina Kato, Takaaki Hasegawa, Kei Muro, Yoshitaka Inaba
PURPOSE: This study aimed to predict the treatment response for colorectal liver metastases (CLM) using relative tumor enhancement (RTE) of the hepatobiliary phase (HBP) for patients with no history of chemotherapy. MATERIALS AND METHODS: In this retrospective study, we enrolled 26 patients [14 males, 12 females; median age: 58 years (range 37-82 years)] with CLM and no history of chemotherapy between December 2011 and May 2017. Gadoxetic acid-enhanced magnetic resonance imaging was performed before starting chemotherapy and RTE of HBP...
April 17, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29651770/the-inhibitory-effect-of-gadoxetate-disodium-on-hepatic-transporters-a-study-using-indocyanine-green
#13
Hiroyuki Akai, Koichiro Yasaka, Akira Kunimatsu, Masanori Nojima, Yusuke Inoue, Osamu Abe, Kuni Ohtomo, Shigeru Kiryu
OBJECTIVES: To assess the inhibitory effect of gadoxetate disodium on the transporter system using indocyanine green (ICG). MATERIALS AND METHODS: Groups of six female B6 Albino mice were injected with the test agent (0.62 mmol/kg gadoxetate disodium) or phosphate-buffered saline (control) 10 min before injection of ICG. Identical fluorescence images were subsequently obtained to create time-efficiency curves of liver parenchymal uptake. The study was performed on hypothermic and normothermic mice...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651764/can-functional-parameters-from-hepatobiliary-phase-of-gadoxetate-mri-predict-clinical-outcomes-in-patients-with-cirrhosis
#14
Kumar Sandrasegaran, Enming Cui, Reem Elkady, Pauley Gasparis, Gitasree Borthakur, Mark Tann, Suthat Liangpunsakul
OBJECTIVES: To determine the value of quantitative parameters of gadoxetate-enhanced magnetic resonance imaging (MRI) in predicting prognosis in patients with cirrhosis. METHODS: A cohort of 63 cirrhotic patients who had gadoxetate MRI and 2-year clinical follow-up was enrolled. Enhancement ratio (ER), contrast enhancement index (CEI) and contrast enhancement spleen index (CES) were calculated. The usefulness of these parameters and clinical scores, such as Child-Pugh score (CPS) and model for end stage liver disease (MELD), in predicting adverse outcomes, such as variceal bleeding (VB), hepatic encephalopathy (HE) and mortality at 2 years were evaluated...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29629800/comparison-of-visualization-rates-of-li-rads-version-2014-major-features-with-iv-gadobenate-dimeglumine-or-gadoxetate-disodium-in-patients-at-risk-for-hepatocellular-carcinoma
#15
Brian C Allen, Lisa M Ho, Tracy A Jaffe, Chad M Miller, Maciej A Mazurowski, Mustafa R Bashir
OBJECTIVE: The purpose of this study is to compare visualization rates of the major features covered by Liver Imaging Reporting and Data System (LI-RADS) version 2014 in patients at risk for hepatocellular carcinoma using either gadobenate dimeglumine or gadoxetate disodium IV contrast agent. MATERIALS AND METHODS: This retrospective study included liver MRI examinations performed with either gadobenate dimeglumine or gadoxetate disodium contrast enhancement. Using age, sex, underlying liver disease, and presence of cirrhosis, patients were placed into matched cohorts...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29532241/gd-eob-dtpa-enhanced-t1-relaxometry-for-assessment-of-liver-function-determined-by-real-time-13-c-methacetin-breath-test
#16
Michael Haimerl, Irene Fuhrmann, Stefanie Poelsterl, Claudia Fellner, Marcel D Nickel, Kilian Weigand, Marc H Dahlke, Niklas Verloh, Christian Stroszczynski, Philipp Wiggermann
OBJECTIVES: To determine whether liver function as determined by intravenous administration of 13 C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) relaxometry. METHODS: Sixty-six patients underwent a 13 C-methacetin breath test (13 C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration...
March 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29526882/thin-slice-free-breathing-pseudo-golden-angle-radial-stack-of-stars-with-gating-and-tracking-t1-weighted-acquisition-an-efficient-gadoxetic-acid-enhanced-hepatobiliary-phase-imaging-alternative-for-patients-with-unstable-breath-holding
#17
Kimihiro Kajita, Satoshi Goshima, Yoshifumi Noda, Hiroshi Kawada, Nobuyuki Kawai, Tomoyuki Okuaki, Masatoshi Honda, Masayuki Matsuo
PURPOSE: To compare four free-breathing scan techniques for gadoxetic acid-enhanced hepatobiliary phase imaging with conventional breath-hold scans. MATERIALS AND METHODS: Gadoxetic acid-enhanced hepatobiliary phase imaging with six image acquisition sets performed in 50 patients. Image acquisition sets included fat-suppressed 3D T1 -weighted turbo field echo with free-breathing pseudo-golden-angle radial stack-of-stars (FBRS) acquisition, FBRS with track (FBRST ), FBRS with gate and track (FBRSG&T ), thin-slice FBRS with gate and track (thin-slice FBRSG&T ), free-breathing Cartesian acquisition (CartesianFB ), and breath-hold Cartesian acquisition (CartesianBH )...
March 9, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29494992/reducing-artifacts-of-gadoxetate-disodium-enhanced-mri-with-oxygen-inhalation-in-patients-with-prior-episode-of-arterial-phase-motion-intra-individual-comparison
#18
Tomohiro Namimoto, Kie Shimizu, Masataka Nakagawa, Yoko Kikuchi, Masafumi Kidoh, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Yasuyuki Yamashita
PURPOSE: To determine whether oxygen inhalation reducing artifacts in patients with previous transient severe motion (TSM) on gadoxetate-disodium-enhanced MRI. MATERIALS AND METHODS: Fifty-one patients with TSM on previous gadoxetate-disodium-enhanced MRI (Baseline examination) were evaluated. Image quality in the examination with oxygen inhalation (Oxygen examination) and that in Baseline examination and the examination before Baseline examination without oxygen inhalation (Past examination) were qualitatively compared in dynamic study...
February 2, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29490696/imaging-features-of-fibrolamellar-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-mri
#19
Viktoria Palm, Ruofan Sheng, Philipp Mayer, Karl-Heinz Weiss, Christoph Springfeld, Arianeb Mehrabi, Thomas Longerich, Anne Katrin Berger, Hans-Ulrich Kauczor, Tim Frederik Weber
BACKGROUND: Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging (HBP) in gadoxetic acid-enhanced liver MRI in patients with FLC and to characterize imaging features in sequence techniques other than HBP. METHODS: In this retrospective study on histology-proven FLC, contrast material uptake in HBP was quantitatively assessed by calculating the corrected FLC enhancement index (CEI) using mean signal intensities of FLC and lumbar muscle on pre-contrast imaging and HBP, respectively...
March 1, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29470629/adding-ancillary-features-to-enhancement-patterns-of-hepatocellular-carcinoma-on-gadoxetic-acid-enhanced-magnetic-resonance-imaging-improves-diagnostic-performance
#20
Ji Hye Min, Young Kon Kim, Dong Hyun Sinn, Seo-Youn Choi, Woo Kyoung Jeong, Won Jae Lee, Sang Yun Ha, Soohyun Ahn, Min-Ji Kim
PURPOSE: To assess the added value of intratumoral ancillary features to conventional enhancement pattern-based diagnosis of hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: A total of 773 consecutive patients with surgically resected 773 primary hepatic tumors (699 HCCs, 63 intrahepatic cholangiocarcinomas, and 11 benign nodules) who underwent gadoxetic acid-enhanced MRI were retrospectively identified...
February 22, 2018: Abdominal Radiology
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