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https://www.readbyqxmd.com/read/28195932/contrast-agent-induced-high-signal-intensity-in-dentate-nucleus-on-unenhanced-t1-weighted-images-comparison-of-gadodiamide-and-gadoxetic-acid
#1
Shintaro Ichikawa, Utaroh Motosugi, Yoshie Omiya, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate whether an association exists between T1-signal increase in the dentate nucleus (DN) on unenhanced magnetic resonance imaging and previous administration of gadoxetic acid and gadodiamide. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board; the requirement for informed patient consent was waived. A total of 132 patients (male-female ratio, 86:46; mean age, 68.8 ± 11.6 years) who underwent imaging between December 2000 and April 2016 were divided into 4 groups: patients with 5 or more administrations of gadoxetic acid ("gadoxetic acid ≥5 administrations" group), only 1 administration of gadoxetic acid ("gadoxetic acid 1 administration" group), no gadolinium-based contrast agent (GBCA) administration or chronic liver disease (CLD; "no GBCA administration and no CLD" group), and 5 or more administrations of gadodiamide ("gadodiamide ≥5 administrations" group)...
February 11, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28190852/characteristics-of-hepatic-schwannoma-presenting-as-an-unusual-multi-cystic-mass-on-gadoxetic-acid-disodium-enhanced-mr-imaging
#2
Hiroki Haradome, Jun Woo, Hisashi Nakayama, Haruna N Watanabe, Masahiro Ogawa, Mitsuhiko Moriyama, Masahiko Sugitani, Tadatoshi Takayama, Osamu Abe
Hepatic schwannoma is a very rare hepatic tumor, usually appearing as a hypervascular solid mass with or without various degrees of cystic changes; however, to the best of our knowledge, only the two cases of hepatic schwannoma showing a multi-cystic appearance have previously been reported. We report herein a benign hepatic schwannoma presenting as an unusually large multi-cystic mass. The gadoxetic acid disodium-enhanced magnetic resonance imaging features are described with the histopathologic correlation and briefly review the literature...
February 13, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28181333/respiratory-motion-artifacts-during-arterial-phase-imaging-with-gadoxetic-acid-can-the-injection-protocol-minimize-this-drawback
#3
Stephan H Polanec, Hubert Bickel, Pascal A T Baltzer, Patrick Thurner, Florian Gittler, Jacqueline C Hodge, Mustafa R Bashir, Ahmed Ba-Ssalamah
PURPOSE: To determine which of three gadoxetic acid injection techniques best reduced the contrast-related arterial-phase motion artifacts. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved, retrospective study included a cohort of 78 consecutive patients who each had serial gadoxetic acid-enhanced 3.0T magnetic resonance imaging (MRI) of the liver (0.025 mmol/kg body weight) performed with at least two of three injection techniques: M1 test bolus, undiluted, power-injected 1 mL/s; M2 test bolus, diluted 50% with saline, power-injected 1 mL/s; M3 fixed delay, undiluted, manually injected...
February 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28177652/irreversible-electroporation-defining-the-mri-appearance-of-the-ablation-zone-with-histopathologic-correlation-in-a-porcine-liver-model
#4
Ely R Felker, Isabel Dregely, Dong Jin Chung, Kyunghyun Sung, Ferdnand C Osuagwu, Charles Lassman, James Sayre, Holden Wu, David S Lu
OBJECTIVE: The purpose of this study is to evaluate the MRI appearance of the irreversible electroporation zone in porcine liver, with histopathologic correlation. MATERIALS AND METHODS: Nine irreversible electroporation ablations were percutaneously created in two Yorkshire pigs. Irreversible electroporation was performed with a bipolar 16-gauge electrode with 3-cm exposure tip and fixed 8-mm interpolar distance. Gadoxetate disodium-enhanced 3-T MRI was performed 50 hours after irreversible electroporation...
February 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28163295/shrunken-hepatic-hemangioma-following-delineated-peritumoral-hyperintensity-on-gadoxetic-acid-disodium-enhanced-mr-imaging
#5
Hiroki Haradome, Takao Okubo, Yusuke Toda, Jun Woo, Tadatoshi Takayama, Osamu Abe
No abstract text is available yet for this article.
February 6, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28153667/quantitative-analysis-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-predicts-histological-grade-of-hepatocellular-carcinoma
#6
Hong-Fei Tong, Hong-Bo Liang, Zhi-Kang Mo, Tian-Pei Guan, Jian Yang, Chi-Hua Fang
OBJECTIVE: To confirm the histological grade of hepatocellular carcinoma (HCC) by gadoxetic acid-enhanced MRI. METHODS: Ninety-five HCC patients underwent gadoxetic acid-enhanced MRI before surgical intervention. The correlations among the signal absolute enhancement, contrast enhancement ratio (CER) and tumor histological grade were analyzed. RESULTS: The correlation between CER of tumor-to-liver and the grades of tumor differentiation is the most significant negative...
January 11, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28144867/removal-of-gadolinium-based-contrast-agents-adsorption-on-activated-carbon
#7
María P Elizalde-González, Esmeralda García-Díaz, Mario González-Perea, Jürgen Mattusch
Three carbon samples were employed in this work, including commercial (1690 m(2) g(-1)), activated carbon prepared from guava seeds (637 m(2) g(-1)), and activated carbon prepared from avocado kernel (1068 m(2) g(-1)), to study the adsorption of the following gadolinium-based contrast agents (GBCAs): gadoterate meglumine Dotarem®, gadopentetate dimeglumine Magnevist®, and gadoxetate disodium Primovist®. The activation conditions with H3PO4 were optimized using a Taguchi methodology to obtain mesoporous materials...
January 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28130583/a-case-of-porphyria-cutanea-tarda-of-the-liver-exhibiting-multifocal-macrovesicular-steatosis-in-the-background-of-microvesicular-steatosis-probably-caused-by-uneven-iron-accumulation
#8
Marie Nishiyama, Keiko Sakamoto, Yoshinobu Shinagawa, Ayako Morita, Hiroshi Urakawa, Ritsuko Fujimitsu, Hiroshi Shakado, Yoshihiro Hamada, Kengo Yoshimitsu
A 61-year-old man with chronic hepatitis B and a history of alcohol overconsumption was admitted to our hospital for the scrutiny of multiple echogenic liver nodules. CT and hepatobiliary phase of gadoxetate-enhanced MR imaging revealed no nodular lesions. Quantitative fat fraction images and R2* map of MR imaging suggested homogeneous steatosis and uneven iron deposition in the liver, namely moderately and severely elevated R2* values at the nodules and surrounding background liver, respectively. Biopsy specimens showed macrovesicular fatty liver and less iron deposition at the echogenic nodules, and microvesicular fatty change and more prominent iron deposition at the surrounding liver tissue...
January 27, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28078380/imaging-features-of-hepatic-sarcomatous-carcinoma-on-computed-tomography-and-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#9
Kyo-Won Gu, Young Kon Kim, Ji Hye Min, Sang Yun Ha, Woo Kyoung Jeong
PURPOSE: To determine the imaging features of hepatic sarcomatous carcinoma including sarcomatous intrahepatic cholangiocarcinoma (S-ICC) and sarcomatous hepatocellular carcinoma (S-HCC) on computed tomography (CT) and gadoxetic acid-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty-four patients with pathologically confirmed S-ICCs (n = 13), S-HCCs (n = 7), sarcomatous carcinoma (n = 2), carcinosarcoma (n = 1), and sarcomatous combined HCC-CC (n = 1) (size range 2...
January 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28076722/is-there-long-term-signal-intensity-increase-in-the-central-nervous-system-on-t1-weighted-images-after-mr-imaging-with-the-hepatospecific-contrast-agent-gadoxetic-acid-a-cross-sectional-study-in-91-patients
#10
Johannes Kahn, Helena Posch, Ingo G Steffen, Dominik Geisel, Christian Bauknecht, Thomas Liebig, Timm Denecke
Purpose To evaluate whether there is T1-weighted signal intensity (SI) increase in the dentate nucleus (DN) and globus pallidus (GP) in relation to the middle cerebellar peduncle (MCP), pons, and thalamus after repeated administration of the liver-specific contrast agent gadoxetic acid. Materials and Methods This was an institutional review board-approved, prospectively conducted (written informed consent acquired), cross-sectional study performed in a consecutively selected patient group (n = 91; patients received one to 37 doses of gadoxetic acid) and a control group (n = 52; subjects had never received injections of gadolinium-based contrast agent) examined with a standard T1-weighted two-dimensional spin-echo pulse sequence of the brain at 1...
March 2017: Radiology
https://www.readbyqxmd.com/read/28028556/effect-of-intravenous-gadoxetate-disodium-and-flip-angle-on-hepatic-proton-density-fat-fraction-estimation-with-six-echo-gradient-recalled-echo-magnitude-based-mr-imaging-at-3t
#11
Charlie C Park, Gavin Hamilton, Ajinkya Desai, Kevin A Zand, Tanya Wolfson, Jonathan C Hooker, Eduardo Costa, Elhamy Heba, Lisa Clark, Anthony Gamst, Rohit Loomba, Michael S Middleton, Claude B Sirlin
PURPOSE: The aim of the study was to determine in patients undergoing gadoxetate disodium (Gx)-enhanced MR exams whether proton density fat fraction (PDFF) estimation accuracy of magnitude-based multi-gradient-echo MRI (MRI-M) could be improved by using high flip angle (FA) on post-contrast images. MATERIALS AND METHODS: Thirty-one adults with known or suspected hepatic steatosis undergoing 3T clinical Gx-enhanced liver MRI were enrolled prospectively. MR spectroscopy (MRS), the reference standard, was performed before Gx to measure MRS-PDFF...
December 28, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/28026208/mri-of-small-hepatocellular-carcinoma-typical-features-are-less-frequent-below-a-size-cutoff-of-1-5-cm
#12
Moon Hyung Choi, Joon-Il Choi, Young Joon Lee, Michael Yong Park, Sung Eun Rha, Chandana Lall
OBJECTIVE: The purposes of this study were to analyze MRI features of small hepatocellular carcinomas (HCCs) on the basis of size and to evaluate the difference in frequency of typical radiologic hallmarks of HCC (arterial enhancement and washout) according to the tumor size. MATERIALS AND METHODS: Enrolled were 86 patients with 110 HCCs 3 cm or smaller who underwent surgical resection or transplantation. Two radiologists reviewed gadoxetic acid-enhanced MRI features for signal intensity of T2-weighted and T1-weighted imaging, diffusion restriction, presence of arterial enhancement, washout on portal and transitional phases, and signal intensity on the hepatobiliary phase...
December 27, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28002336/the-utility-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-in-the-surveillance-for-postoperative-recurrence-of-hepatocellular-carcinoma
#13
Jung Hee Kim, Yang Won Min, Geum-Youn Gwak, Yong Han Paik, Moon Seok Choi, Joon Hyoek Lee, Kwang Cheol Koh, Seung Woon Paik
This study aimed to investigate the utility of gadoxetic acid-enhanced magnetic resonance imaging (Gd-MRI) in surveillance for recurrent hepatocellular carcinoma (HCC) after hepatectomy.This retrospective study analyzed 147 patients who underwent surveillance with alternating multidetector computed tomography (MDCT) and Gd-MRI after hepatectomy for HCC. The patients were followed-up every 3 months during the first 2 years, and every 6 months thereafter. At each visit, MDCT was performed but once a year (every 12 months), Gd-MRI was performed instead of MDCT...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28002117/quantitative-assessment-of-liver-function-using-gadoxetate-enhanced-magnetic-resonance-imaging-monitoring-transporter-mediated-processes-in-healthy-volunteers
#14
Leonidas Georgiou, Jeffrey Penny, Glynis Nicholls, Neil Woodhouse, François-Xavier Blé, Penny L Hubbard Cristinacce, Josephine H Naish
OBJECTIVE: The objective of this study was to use noninvasive dynamic contrast-enhanced magnetic resonance imaging (MRI) techniques to study, in vivo, the distribution and elimination of the hepatobiliary contrast agent gadoxetate in the human body and characterize the transport mechanisms involved in its uptake into hepatocytes and subsequent efflux into the bile using a novel tracer kinetic model in a group of healthy volunteers. MATERIALS AND METHODS: Ten healthy volunteers (age range, 18-29 years), with no history of renal or hepatic impairment, were recruited via advertisement...
February 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27986174/avoiding-pitfalls-in-the-interpretation-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#15
Marco Dioguardi Burgio, Maxime Ronot, Luisa Paulatto, Sylvain Terraz, Valérie Vilgrain, Giuseppe Brancatelli
Gadoxetic acid is extensively used in the following 3 main clinical situations: characterization of small nodules in patients with cirrhosis, preoperative staging of liver metastases, and characterization of incidentally discovered focal liver lesions. Owing to the rapid entry of gadoxetic acid into hepatocytes, the traditional features of liver tumors are modified on magnetic resonance (MR) imaging, especially during delayed phase sequences. Thus, although the added value of gadoxetic acid for the detection and characterization of focal liver lesions is now clear, its unique pharmacokinetics as well as the presence of mimicking and atypical lesions may lead to misdiagnoses...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27986173/liver-function-assessment-by-magnetic-resonance-imaging
#16
Emre Ünal, Deniz Akata, Musturay Karcaaltincaba
Liver function assessment by hepatocyte-specific contrast-enhanced magnetic resonance imaging is becoming a new biomarker. Liver function can be assessed by T1 mapping (reduction rate) and signal intensity measurement (relative enhancement ratio) before and after GD-EOB-DTPA (gadoxetic acid) administration, as alternative to Tc-99m galactosyl serum albumin scintigraphy, 99m Tc-labeled mebrofenin scintigraphy, and indocyanine green clearance test. Magnetic resonance imaging assessment of liver function can enable diagnosis of cirrhosis, nonalcoholic fatty liver disease associated fibrosis and steatohepatitis, primary sclerosing cholangitis, toxic hepatitis, and chemotherapy and radiotherapy-related changes, which may be only visible on hepatobiliary phase images...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27977329/reducing-artifacts-during-arterial-phase-of-gadoxetate-disodium-enhanced-mr-imaging-dilution-method-versus-reduced-injection-rate
#17
Young Kon Kim, Wei-Chan Lin, Kyunghyun Sung, Steven S Raman, Daniel Margolis, Yaeji Lim, Seonhye Gu, David Lu
Purpose To compare two contrast material-administration protocols (dilution vs slow injection) in terms of their effectiveness in arterial phase artifact reduction at gadoxetic acid-enhanced magnetic resonance (MR) imaging. Materials and Methods This HIPAA-compliant retrospective case-controlled cohort study was approved by the institutional review board, with a waiver of informed patient consent. A total of 318 consecutive patients undergoing gadoxetic acid-enhanced MR imaging were placed into one of two subcohorts of 159 consecutive patients each: the dilution subcohort (gadoxetic acid was diluted 1:1 with saline and injected at a rate of 2...
December 15, 2016: Radiology
https://www.readbyqxmd.com/read/27957635/gadoxetic-acid-enhanced-magnetic-resonance-imaging-characteristics-of-hepatocellular-carcinoma-occurring-in-liver-transplants
#18
Mimi Kim, Tae Wook Kang, Woo Kyoung Jeong, Young Kon Kim, Seong Hyun Kim, Jong Man Kim, Dong Hyun Sinn, Min-Ji Kim, Sin-Ho Jung
OBJECTIVES: Characteristics of hepatocellular carcinoma (HCC) on magnetic resonance (MR) images were compared in patients who did or did not undergo liver transplantation (LT), and we evaluated the relationship of these findings with overall survival (OS) and time-to-tumour recurrence (TTR) after transplantation. METHODS: The enhancement pattern of gadoxetic acid-enhanced MR images of 25 patients with recurrent HCCs (LT group) and 25 surgically confirmed HCC patients in the non-transplanted (control) group were compared...
December 12, 2016: European Radiology
https://www.readbyqxmd.com/read/27943555/spio-enhanced-mri-is-useful-in-predicting-malignant-potential-of-vascular-transformation-of-hypointense-hypovascular-nodules-on-gd-eob-dtpa-enhanced-mri
#19
Yoshiaki Tanaka, Takahide Nakazawa, Tomoyoshi Inoue, Keiko Yamane, Kousuke Kubota, Haruki Uojima, Juichi Takada, Yusuke Okuwaki, Hisashi Hidaka, Akitaka Shibuya, Shigehiro Kokubu, Keiji Matsunaga, Wasaburo Koizumi
AIM: To examine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) can be used to assess the malignant potential of hepatic hypovascular nodules showing hypointensity during the hepatobiliary phase (HBP) on gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The study included 42 patients with chronic liver disease who had small hypovascular nodules (5-15 mm) showing hypointensity during the HBP on Gd-EOB-DTPA-enhanced MRI. SPIO-enhanced T2-weighted MRI analyzed whether the signal intensity of each nodule was high...
December 11, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27933441/multimodality-imaging-to-assess-immediate-response-following-irreversible-electroporation-in-patients-with-malignant-hepatic-tumors
#20
Katsutoshi Sugimoto, Fuminori Moriyasu, Kazuhiro Saito, Yoshiyuki Kobayashi, Takao Itoi
PURPOSE: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS), contrast-enhanced multiphase CT (CECT), and gadoxetic acid-enhanced MRI (EOB-MRI) in identifying residual tumor in the subacute follow-up of patients with malignant hepatic tumors treated by irreversible electroporation (IRE). METHODS: We enrolled 16 patients with 21 hepatic lesions treated by IRE and examined by CEUS and CECT at 1 day after IRE and by EOB-MRI at 7 days after IRE...
December 8, 2016: Journal of Medical Ultrasonics
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