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Autonomic dysregulation

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https://www.readbyqxmd.com/read/29677475/molecular-and-functional-neuroscience-in-immunity
#1
Valentin A Pavlov, Sangeeta S Chavan, Kevin J Tracey
The nervous system regulates immunity and inflammation. The molecular detection of pathogen fragments, cytokines, and other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. The functional organization of this neural control is based on principles of reflex regulation. Reflexes involving the vagus nerve and other nerves have been therapeutically explored in models of inflammatory and autoimmune conditions, and recently in clinical settings...
April 26, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29661162/the-cold-pressor-test-in-interictal-migraine-patients-different-parasympathetic-pupillary-response-indicates-dysbalance-of-the-cranial-autonomic-nervous-system
#2
Ozan E Eren, Ruth Ruscheweyh, Christoph Schankin, Florian Schöberl, Andreas Straube
BACKGROUND: Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous system. In the present study, we explicitly aimed to assess the cranial ANS in migraine patients compared to healthy controls by applying the cold pressor test to a cohort of migraine patients in the interictal phase and measuring the pupillary response. METHODS: In this prospective observational study, a strong sympathetic stimulus was applied to 20 patients with episodic migraine in the interictal phase and 20 matched controls without migraine, whereby each participant dipped the left hand into ice-cold (4 °C) water for a maximum of 5 min (cold pressor test)...
April 16, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29652832/sympathetic-nerve-hyperactivity-in-the-spleen-causal-for-nonpathogenic-driven-chronic-immune-mediated-inflammatory-diseases-imids
#3
REVIEW
Denise L Bellinger, Dianne Lorton
Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic group of diseases or conditions that share common inflammatory pathways, and for which there is no definitive etiology. IMIDs affect the elderly most severely, with many older individuals having two or more IMIDs. These diseases include, but are not limited to, type-1 diabetes, obesity, hypertension, chronic pulmonary disease, coronary heart disease, inflammatory bowel disease, and autoimmunity, such as rheumatoid arthritis (RA), Sjőgren's syndrome, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and multiple sclerosis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652305/-efficiency-of-neuromultivit-in-complex-therapy-of-patients-with-rheumatoid-arthritis-associated-with-diabetes-mellitus
#4
L N Eliseeva, A Yu Selimov, A Yu Blednova, Zh Z Otarova, M I Bocharnikova, V S Seredinsky
AIM: To examine the dysregulation of the autonomic nervous system and manifestations of pain syndrome in patients with rheumatoid arthritis combined with diabetes mellitus and the possibility of their correction in patients who receive complex therapy including neurotropic vitamins (neuromultivitis). MATERIAL AND METHODS: One hundred and forty-six patients with rheumatoid disease were examined including 59 patients with diabetes mellitus. RESULTS AND CONCLUSION: When testing for the presence of neuropathic pain syndrome using the diagnostic questionnaire of neuropathic pain (DN4), a greater prevalence of these features was revealed, with a high correlation with the duration of rheumatoid arthritis (r=0,56) and duration of diabetes mellitus (r=0,82)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29650758/the-fructose-2-6-bisphosphatase-tigar-suppresses-nf-%C3%AE%C2%BAb-signaling-by-directly-inhibiting-the-linear-ubiquitin-assembly-complex-lubac
#5
Yan Tang, Hyokjoon Kwon, Brian A Neel, Michal Kasher-Meron, Jacob Pessin, Eijiro Yamada, Jeffrey E Pessin
The systems integration of whole-body metabolism and immune signaling are central homeostatic mechanisms necessary for maintenance of normal physiology, and dysregulation of these processes leads to a variety of chronic disorders. However, the intracellular mechanisms responsible for cell-autonomous cross talk between the inflammatory signaling pathways and metabolic flux have remained enigmatic. In this study, we discovered that the fructose-2,6-bisphosphatase TIGAR (Tp53-induced glycolysis and apoptosis regulator) critically regulates NF-κB activation...
April 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29627087/autonomic-nervous-system-in-paralympic-athletes-with-spinal-cord-injury
#6
REVIEW
Matthias Walter, Andrei V Krassioukov
Individuals sustaining a spinal cord injury (SCI) frequently suffer from sensorimotor and autonomic impairment. Damage to the autonomic nervous system results in cardiovascular, respiratory, bladder, bowel, and sexual dysfunctions, as well as temperature dysregulation. These complications not only impede quality of life, but also affect athletic performance of individuals with SCI. This article summarizes existing evidence on how damage to the spinal cord affects the autonomic nervous system and impacts the performance in athletes with SCI...
May 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29626741/prescription-opioid-misusing-chronic-pain-patients-exhibit-dysregulated-context-dependent-associations-investigating-associative-learning-in-addiction-with-the-cue-primed-reactivity-task
#7
Eric L Garland, Craig J Bryan, Lydia Kreighbaum, Yoshio Nakamura, Matthew O Howard, Brett Froeliger
BACKGROUND: Associative learning undergirds the development of addiction, such that drug-related cues serve as conditioned stimuli to elicit drug-seeking responses. Plausibly, among opioid misusing chronic pain patients, pain-related information may serve as a conditioned stimulus to magnify opioid cue-elicited autonomic and craving responses through a process of second-order conditioning. METHODS: We utilized a novel psychophysiological probe of pain-opioid conditioned associations, the Cue-Primed Reactivity (CPR) task...
March 27, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29623047/sympathetic-metabolic-adaptations-and-oxidative-stress-in-autism-spectrum-disorders-how-far-from-physiology
#8
Antonietta Messina, Vincenzo Monda, Francesco Sessa, Anna Valenzano, Monica Salerno, Ilaria Bitetti, Francesco Precenzano, Rosa Marotta, Francesco Lavano, Serena M Lavano, Margherita Salerno, Agata Maltese, Michele Roccella, Lucia Parisi, Roberta I Ferrentino, Gabriele Tripi, Beatrice Gallai, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina, Marco Carotenuto
Autism spectrum disorders (ASD) is a complex and multifaceted neurobehavioral syndrome with no specific cause still identified, despite the worldwide increasing (prevalence for 1,000 children from 6.7 to 14.6, between 2000 and 2012). Many biological and instrumental markers have been suggested as potential predictive factors for the precocious diagnosis during infancy and/or pediatric age. Many studies reported structural and functional abnormalities in the autonomic system in subjects with ASD. Sleep problems in ASD are a prominent feature, having an impact on the social interaction of the patient...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29621046/persistent-physical-symptoms-as-perceptual-dysregulation-a-neuropsychobehavioral-model-and-its-clinical-implications
#9
Peter Henningsen, Harald Gündel, Willem J Kop, Bernd Löwe, Alexander Martin, Winfried Rief, Judith G M Rosmalen, Andreas Schröder, Christina van der Feltz-Cornelis, Omer Van den Bergh
OBJECTIVE: The mechanisms underlying the perception and experience of persistent physical symptoms are not well understood, and in the models, the specific relevance of peripheral input versus central processing, or of neurobiological versus psychosocial factors in general, is not clear.In this article, we propose a model for this clinical phenomenon that is designed to be coherent with an underlying, relatively new model of the normal brain functions involved in the experience of bodily signals...
April 4, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29609720/heart-rate-variability-responses-of-individuals-with-and-without-saline-induced-obstructive-sleep-apnea
#10
Daniel Vena, T Douglas Bradley, Philip J Millar, John S Floras, Jonathan Rubianto, Bojan Gavrilovic, Elisa Perger, Azadeh Yadollahi
STUDY OBJECTIVES: Postoperative development of obstructive sleep apnea (OSA) has been attributed to the fluid overloaded state of patients during the postoperative period. In this context, alterations in cardiac autonomic regulation caused by OSA may explain the increased postoperative risk for adverse cardiovascular events. This study tests the hypothesis that individuals with fluid overload-induced OSA will experience autonomic dysregulation, compared to those without fluid overload-induced OSA...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29572132/sleep-biology-updates-hemodynamic-and-autonomic-control-in-sleep-disorders
#11
REVIEW
Renaud Tamisier, J Woodrow Weiss, Jean Louis Pépin
Sleep disorders like obstructive sleep apnea syndrome, periodic limb movements in sleep syndrome, insomnia and narcolepsy-cataplexy are all associated with an increased risk of cardiovascular diseases. These disorders share an impaired autonomic nervous system regulation that leads to increased cardiovascular sympathetic tone. This increased cardiovascular sympathetic tone is, in turn, likely to play a major role in the increased risk of cardiovascular disease. Different stimuli, such as intermittent hypoxia, sleep fragmentation, decrease in sleep duration, increased respiratory effort, and transient hypercapnia may all initiate the pathophysiological cascade leading to sympathetic overactivity and some or all of these are encountered in these different sleep disorders...
March 20, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29571868/neuromuscular-diseases-associated-with-human-immunodeficiency-virus-infection
#12
REVIEW
Devin E Prior, Nancy Song, Jeffrey A Cohen
From the most common distal symmetric polyneuropathy (Bilgrami and O'Keefe, 2014) to the rare motor neuron diseases, HIV infection is associated with pathology at all levels of the peripheral nervous system. HIV infection can cause these conditions due to viral exposure itself, the resulting immune dysregulation, opportunistic infections found in untreated patients, and from the therapy used in treatment of the virus. Before the advent of antiretroviral therapy, 5 neuromuscular diseases associated with HIV often resulted from opportunistic infections...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29561920/the-symptom-burden-of-autonomic-dysfunction-is-positively-associated-with-chronic-rhinosinusitis-status
#13
W C Chen, Y T Chang, S F Chen, W C Lin, Y Y Su, S D Luo
BACKGROUND: Dysregulation of the autonomic system can affect sinonasal physiological function and may exacerbate the symptom burden associated with rhinosinusitis. However, the association between autonomic dysfunction and chronic rhinosinusitis (CRS) has seldom been studied. Here, we investigated the relationship between autonomic dysfunction and CRS. METHODS: Patients with CRS who failed medical treatment were prospectively enrolled. All patients underwent pre-operative examinations and completed questionnaires, including the reflux symptom index (RSI) and the Sino-nasal Outcome Test-22 (SNOT-22)...
March 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29553042/a-rare-cause-of-hypothalamic-obesity-rohhad-syndrome-2-cases
#14
Ülkü Gül Şiraz, Deniz Okdemir, Gül Direk, Leyla Akın, Nihal Hatipoğlu, Mustafa Kendırcı, Selim Kurtoğlu
Rapid-onset obesity with hypoventilation, hypothalamic dysfunction and autonomic dysregulation (ROHHAD) syndrome is a rare disease that is difficult to diagnosis and distinguish from genetic obesity syndromes. The underlying causes of the disease has not been fully explained. Hypothalamic dysfunction causes endocrine problems, respiratory dysfunction and autonomic alterations. There are around 80 reported patients due to lack of recognition. We present two female patient suspected of ROHHAD due to weight gain since early childhood...
March 19, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29543914/immunoadsorption-to-remove-%C3%A3-2-adrenergic-receptor-antibodies-in-chronic-fatigue-syndrome-cfs-me
#15
Carmen Scheibenbogen, Madlen Loebel, Helma Freitag, Anne Krueger, Sandra Bauer, Michaela Antelmann, Wolfram Doehner, Nadja Scherbakov, Harald Heidecke, Petra Reinke, Hans-Dieter Volk, Patricia Grabowski
INTRODUCTION: Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) point to an autoimmune disease directed against neurotransmitter receptors. We had observed elevated autoantibodies against ß2 adrenergic receptors, and muscarinic 3 and 4 acetylcholine receptors in a subset of patients. Immunoadsorption (IA) was shown to be effective in removing autoantibodies and improve outcome in various autoimmune diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29540066/a-systematic-review-of-biological-mechanisms-of-fatigue-in-chronic-illness
#16
Lea Ann Matura, Susan Malone, Rosario Jaime-Lara, Barbara Riegel
Fatigue, a commonly reported symptom, is defined as an overwhelming, debilitating, and sustained sense of exhaustion that decreases the ability to function and carry out daily activities. To date, cancer researchers have been in the forefront in investigating the possible biological mechanisms of fatigue, identifying inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and activation of the autonomic nervous system. The purpose of this systematic review is to describe fatigue and what is known about the biological mechanisms described in cancer in five chronic, noninfectious illnesses: heart failure, multiple sclerosis, chronic kidney disease, rheumatoid arthritis, and chronic obstructive pulmonary disease...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29535811/thyroid-follicular-adenomas-and-carcinomas-molecular-profiling-provides-evidence-for-a-continuous-evolution
#17
Geneviève Dom, Sandra Frank, Sebastien Floor, Pashalina Kehagias, Frederick Libert, Catherine Hoang, Guy Andry, Alex Spinette, Ligia Craciun, Nicolas de Saint Aubin, Christophe Tresallet, Frederique Tissier, Frederique Savagner, Samira Majjaj, Ilse Gutierrez-Roelens, Etienne Marbaix, Jacques E Dumont, Carine Maenhaut
Non-autonomous thyroid nodules are common in the general population with a proportion found to be cancerous. A current challenge in the field is to be able to distinguish benign adenoma (FA) from preoperatively malignant thyroid follicular carcinoma (FTC), which are very similar both histologically and genetically. One controversial issue, which is currently not understood, is whether both tumor types represent different molecular entities or rather a biological continuum. To gain a better insight into FA and FTC tumorigenesis, we defined their molecular profiles by mRNA and miRNA microarray...
February 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29535648/somatic-experiencing-%C3%A2-informed-therapeutic-group-for-the-care-and-treatment-of-biopsychosocial-effects-upon-a-gender-diverse-identity
#18
Paul C Briggs, Sage Hayes, Michael Changaris
Background: Somatic Experiencing® (SE™) is a resiliency-based treatment for autonomic nervous systems dysregulation syndromes, such as posttraumatic stress disorder, anxiety, depression, and physical syndromes like chronic pain, migraines, and fibromyalgia. "Transgender/gender non-conforming/gender variant" describes people whose gender identity/expression is different, at least part of the time, from the sex assigned at birth. Research indicates transgender individuals have a higher incidence of depression, anxiety, victimization, and discrimination...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29534967/mitochondrial-dysfunction-in-dopaminergic-neurons-differentiated-from-exfoliated-deciduous-tooth-derived-pulp-stem-cells-of-a-child-with-rett-syndrome
#19
Saki Hirofuji, Yuta Hirofuji, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Hiroshi Sato, Fumiko Takayama, Michiko Torio, Yasunari Sakai, Shouichi Ohga, Tomoaki Taguchi, Kazuaki Nonaka
Rett syndrome is an X-linked neurodevelopmental disorder associated with psychomotor impairments, autonomic dysfunctions and autism. Patients with Rett syndrome have loss-of-function mutations in MECP2, the gene encoding methyl-CpG-binding protein 2 (MeCP2). Abnormal biogenic amine signaling and mitochondrial function have been found in patients with Rett syndrome; however, few studies have analyzed the association between these factors. This study investigated the functional relationships between mitochondria and the neuronal differentiation of the MeCP2-deficient stem cells from the exfoliated deciduous teeth of a child with Rett syndrome...
March 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29524627/calcium-activated-sk-potassium-channels-are-key-modulators-of-the-pacemaker-frequency-in-locus-coeruleus-neurons
#20
Lina A Matschke, Susanne Rinné, Terrance P Snutch, Wolfgang H Oertel, Amalia M Dolga, Niels Decher
The physiological, intrinsic activity of noradrenergic locus coeruleus (LC) neurons is important for the control of sleep/wakefulness, cognition and autonomous body functions. Dysregulations of the LC-noradrenergic network contribute to the pathogenesis of psychiatric disorders and are key findings in early stages of neurodegenerative diseases. Therefore, identifying ion channels mediating the intrinsic pacemaking mechanism of LC neurons, which is in turn directly coupled to Ca2+ homeostasis and cell survival signaling pathways, can help to foster our understanding of the vulnerability of these neurons in neurodegenerative diseases...
March 7, 2018: Molecular and Cellular Neurosciences
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