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https://www.readbyqxmd.com/read/29679851/electronic-journal-clubs-for-capacity-building-a-case-study-in-psychiatry-as-a-model-for-medical-disciplines-in-developing-countries
#1
Abha Thakurdesai, Abhishek Ghosh, Vikas Menon, Swapnajeet Sahoo, Adarsh Tripathi, Devavrat Harshe, Chittaranjan Andrade
BACKGROUND: Journal clubs (JCs) teach participants how to critically read and assimilate materials published in journals. Electronic JCs (eJCs) provide a similar platform through internet groups, allowing members to participate in and review JC activities as well as JC archives in their free time. METHODS: We describe the operations and the successes of eJCIndia, to our knowledge the first eJC in India in the field of mental health. eJCIndia was started for capacity building in teaching and research competence in the field...
April 13, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29616562/avelumab-a-review-of-its-application-in-metastatic-merkel-cell-carcinoma
#2
Jocelyn Joseph, Chrystia Zobniw, Jennifer Davis, Jaime Anderson, Van Anh Trinh
OBJECTIVE: To summarize the clinical development of avelumab and its clinical relevance in metastatic Merkel cell carcinoma (MCC). DATA SOURCES: An English-language literature search using PubMed was performed using the terms avelumab, anti-PD-1, anti-PD-L1, and MCC from January of 1950 to March 2018. Data were also obtained from package inserts, meeting abstracts, and clinical registries. STUDY SELECTION/DATA EXTRACTION: All relevant published articles of avelumab were reviewed...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29576434/surgical-versus-medical-treatment-of-drug-resistant-epilepsy-a-systematic-review-and-meta-analysis
#3
REVIEW
Jin-Tao Liu, Bei Liu, Hua Zhang
OBJECTIVE: Surgery and drug therapy are the two main treatments for refractory epilepsy. However, to date, there has not been an adequate comparison of the outcomes of these two treatments. This systematic review compared the overall outcome of surgery and medical treatment in patients with drug-resistant epilepsy. METHODS: Articles published in Embase, Medline, Pubmed, and the Cochrane library were searched from their inception until June 2016. RESULTS: Twenty of the eighty-one (24...
March 23, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29554317/stereotactic-radiosurgery-for-benign-world-health-organization-grade-i-cavernous-sinus-meningiomas-international-stereotactic-radiosurgery-society-isrs-practice-guideline-a-systematic-review
#4
Cheng-Chia Lee, Daniel M Trifiletti, Arjun Sahgal, Antonio DeSalles, Laura Fariselli, Motohiro Hayashi, Marc Levivier, Lijun Ma, Roberto Martínez Álvarez, Ian Paddick, Jean Regis, Samuel Ryu, Ben Slotman, Jason Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) has become popular as a standard treatment for cavernous sinus (CS) meningiomas. OBJECTIVE: To summarize the published literature specific to the treatment of CS meningioma with SRS found through a systematic review, and to create recommendations on behalf of the International Stereotactic Radiosurgery Society. METHODS: Articles published from January 1963 to December 2014 were systemically reviewed...
March 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29527146/a-review-of-the-relationships-among-the-key-determinants-affecting-the-mental-health-disorders-of-the-people-in-greater-mekong-subregion-countries
#5
REVIEW
Manndy Nget, Kasorn Muijeen
Background: ASEAN integration aims to transform the GMS into a single market with free flows of products, services, and skilled labor, as well as investment openness, which will ultimately force regional economic growth. Therefore, this integration is likely to bring about a big change to this area in the new era; it can subsequently cause many problems as well, including mental health issues of the people in this region. The characteristic differences among the GMS member countries in terms of trade and investment, so-cial and cultural values, medical information and technology, and the living and working environment have become major problems affecting mental health disorders, which are usually identified as depression, stress, and substance abuse...
December 2017: Current Psychiatry Reviews
https://www.readbyqxmd.com/read/29523018/aromatherapy-for-treatment-of-postoperative-nausea-and-vomiting
#6
REVIEW
Sonia Hines, Elizabeth Steels, Anne Chang, Kristen Gibbons
BACKGROUND: Postoperative nausea and vomiting (PONV) is a common, unpleasant phenomenon and current therapies are not always effective for all patients. Aromatherapy has been suggested as an addition to the available treatment strategies. This review was originally published in 2012 and updated in 2017. OBJECTIVES: The main objective was to establish the efficacy and safety of aromatherapy comparable to standard pharmacological treatments for PONV in adults and children...
March 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29463003/the-mirna-mirage-how-close-are-we-to-finding-a-non-invasive-diagnostic-biomarker-in-endometriosis-a-systematic-review
#7
REVIEW
Swati Agrawal, Thomas Tapmeier, Nilufer Rahmioglu, Shona Kirtley, Krina Zondervan, Christian Becker
BACKGROUND: Endometriosis is a common disorder of the reproductive age group, characterised by the presence of ectopic endometrial tissue. The disease not only causes enormous suffering to the affected women, but also brings a tremendous medical and economic burden to bear on society. There is a long lag phase between the onset and diagnosis of the disease, mainly due to its non-specific symptoms and the lack of a non-invasive test. Endometriosis can only be diagnosed invasively by laparoscopy...
February 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29420303/prognostic-value-of-he4-in-patients-with-ovarian-cancer
#8
REVIEW
Cunzhong Yuan, Rongrong Li, Shi Yan, Beihua Kong
Background There is no consensus in the medical community about the prognostic role of preoperative serum levels of human epididymis protein 4 (HE4) in ovarian cancer (OC). The purpose of this meta-analysis was to establish whether preoperative serum levels of HE4 are associated with OC prognosis. Content Eligible studies were searched for in PubMed, ClinicalTrials.gov, CNKI and Wanfang Med Online. We performed a meta-analysis of 1315 OC cases from 14 published articles. Summary Our meta-analysis demonstrated that high HE4 was associated with poor overall survival (OS) (random effects model, hazard ratio [HR]=1...
February 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29362840/role-of-interventional-radiology-in-managing-pediatric-liver-tumors-part-1-endovascular-interventions
#9
REVIEW
Matthew P Lungren, Alexander J Towbin, Derek J Roebuck, Eric J Monroe, Anne E Gill, Avnesh Thakor, Richard B Towbin, Anne Marie Cahill, C Matthew Hawkins
Primary liver malignancies are rare in children. Hepatoblastoma and hepatocellular carcinoma (HCC) together represent the overwhelming majority of cases. Overall survival of hepatoblastoma approaches 80% with multimodal treatment approaches that include chemotherapy, surgery and transplantation. However, there remains a subset of children with hepatoblastoma in whom resection or transplantation is not possible. The 5-year survival for children diagnosed with HCC is less than 30% and remains a significant therapeutic challenge...
April 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29316001/directly-observed-therapy-of-chronic-hepatitis-c-with-ledipasvir-sofosbuvir-in-people-who-inject-drugs-at-risk-of-nonadherence-to-direct-acting-antivirals
#10
A Schütz, S Moser, C Schwanke, R Schubert, J Luhn, E Gutic, T Lang, M Schleicher, H Haltmayer, M Gschwantler
An important subgroup of people who inject drugs (PWID) receiving opioid agonist therapy (OAT) cannot be treated in the setting of a hepatology centre and would not regularly ingest their medication when handed to them for self-administration. Our hypothesis was that chronic hepatitis C in these patients could be ideally managed if modern, interferon-free regimens were administered together with OAT under direct observation of a physician or nurse at a low-threshold facility. In this open-label, noninterventional, proof-of-concept study (ClinicalTrials...
January 5, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29315813/liver-transplantation-vs-liver-resection-in-patients-with-hbv-related-hepatocellular-carcinoma-beyond-milan-criterion-a-meta-analysis
#11
REVIEW
Wei Li, Long Li, Jun Han, Hong Wu
OBJECTIVE: The aim of this study was to conduct a meta-analysis of published reports to compare long-term outcomes after liver transplantation (LT) and liver resection (LR), respectively, in patients with HBV-related hepatocellular carcinoma (HCC) beyond the Milan criterion. METHODS: A systematic search of the Embase, Medline, PubMed databases, and the Cochrane Library was performed using both medical subject headings (MeSH) and truncated word searches to identify all comparative studies published on this topic...
March 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29289535/female-sexual-function-following-surgical-treatment-of-stress-urinary-incontinence-systematic-review-and-meta-analysis
#12
REVIEW
Maria Cláudia Bicudo-Fürst, Pedro Henrique Borba Leite, Felipe Placco Araújo Glina, Willy Baccaglini, Rafael Vilhena de Carvalho Fürst, Carlos Alberto Bezerra, Sidney Glina
INTRODUCTION: The impact of surgery for stress urinary incontinence (SUI) on female sexual function has received attention in the medical literature, but not in a structured manner. AIM: To assess the most recent evidence on the impact of surgical management for female SUI on female sexual function. METHODS: The review and meta-analysis of available articles published in Medline, Cochrane, LILACS, SCOPUS, Web of Science, CINHAL, and EMBASE included prospective randomized and non-randomized studies that assessed patients who underwent surgical treatment for UI through 2 validated questionnaires: the Pelvic Organ Prolapse Urinary Incontinence Sexual Questionnaire (PISQ-12) and the Female Sexual Function Index (FSFI)...
April 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29140658/killing-u-s-slowly-curing-the-epidemic-rise-of-cancer-drug-prices
#13
Emily K White
In August 2015, more than 110 U.S. oncologists published an article detailing the deleterious effects of rising cancer drugs prices and calling for numerous reforms to our prescription drug system. These prices are the result of decades of political maneuvering; they reflect the way our country has chosen to pay for healthcare, to foster and reward innovation, and to promote a national free market system. While these choices have resulted in immense profits for pharmaceutical companies—and subsidized the development of prescription drugs globally—they have also left many cancer patients unable to afford their medications...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29095272/treatment-of-triple-negative-breast-cancer-with-chinese-herbal-medicine-a-prospective-cohort-study-protocol
#14
MULTICENTER STUDY
Hui Meng, Nan Peng, Mingwei Yu, Xu Sun, Yunfei Ma, Guowang Yang, Xiaomin Wang
INTRODUCTION: Triple-negative breast cancer (TNBC) is featured with the biological properties of strong aggressive behaviors, rapid disease progression, high risk of recurrence and metastasis, and low disease free survival. Patients with this tumor are insensitive to the endocrine therapy and target treatment for HER-2; therefore, chemotherapy is often used as routine treatment in clinical. Because of the fact that a considerable number of patients seek for Chinese herbal medicine (CHM) treatment after operation and chemotherapy and (or) radiotherapy, it is thus need to evaluate the correlation between Chinese herbal medicine treatment and prognosis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29091742/biosecurity-implications-for-the-synthesis-of-horsepox-an-orthopoxvirus
#15
Diane DiEuliis, Kavita Berger, Gigi Gronvall
This article examines the biosecurity and biodefense implications resulting from the recent creation of horsepox virus, a noncirculating (extinct) species of orthopoxvirus. Here we examine the technical aspects of the horsepox virus synthesis and conclude that orthopox synthesis experiments currently remain technically challenging-and will continue to be so, even once this work is published in the scientific literature. This limits potential misuse by some types of nefarious actors. We also examine the implications of one stated purpose for the recreation of horsepox virus: the development of a smallpox vaccine...
November 2017: Health Security
https://www.readbyqxmd.com/read/29063547/clinical-information-systems-as-the-backbone-of-a-complex-information-logistics-process-findings-from-the-clinical-information-systems-perspective-for-2016
#16
REVIEW
W O Hackl, T Ganslandt
Objective: To summarize recent research and to propose a selection of best papers published in 2016 in the field of Clinical Information Systems (CIS). Method: The query used to retrieve the articles for the CIS section of the 2016 edition of the IMIA Yearbook of Medical Informatics was reused. It again aimed at identifying relevant publications in the field of CIS from PubMed and Web of Science and comprised search terms from the Medical Subject Headings (MeSH) catalog as well as additional free text search terms...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063546/clinical-information-systems-as-the-backbone-of-a-complex-information-logistics-process-findings-from-the-clinical-information-systems-perspective-for-2016
#17
W O Hackl, T Ganslandt
Objective: To summarize recent research and to propose a selection of best papers published in 2016 in the field of Clinical Information Systems (CIS). Method: The query used to retrieve the articles for the CIS section of the 2016 edition of the IMIA Yearbook of Medical Informatics was reused. It again aimed at identifying relevant publications in the field of CIS from PubMed and Web of Science and comprised search terms from the Medical Subject Headings (MeSH) catalog as well as additional free text search terms...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29051136/using-google-glass-in-nonsurgical-medical-settings-systematic-review
#18
Bryn Dougherty, Sherif M Badawy
BACKGROUND: Wearable technologies provide users hands-free access to computer functions and are becoming increasingly popular on both the consumer market and in various industries. The medical industry has pioneered research and implementation of head-mounted wearable devices, such as Google Glass. Most of this research has focused on surgical interventions; however, other medical fields have begun to explore the potential of this technology to support both patients and clinicians. OBJECTIVE: Our aim was to systematically evaluate the feasibility, usability, and acceptability of using Google Glass in nonsurgical medical settings and to determine the benefits, limitations, and future directions of its application...
October 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28978212/overview-of-idiopathic-pulmonary-fibrosis-ipf-and-evidence-based-guidelines
#19
Roozbeh Sharif
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive form of interstitial lung disease (ILD), characterized by fibrosis and worsening lung function, that primarily occurs in those 50 years and older. Various causes including genetic susceptibility, environmental risk factors, and exposures have been suggested in the literature. All of these cause repetitive micro-injury to the lung tissue and vasculature, which triggers a cascade of inflammatory response and fibrosis. Symptoms are nonspecific and most patients present several years after the initial radiographic changes occur...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28913837/practical-recommendations-for-reporting-fine-gray-model-analyses-for-competing-risk-data
#20
Peter C Austin, Jason P Fine
In survival analysis, a competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. Outcomes in medical research are frequently subject to competing risks. In survival analysis, there are 2 key questions that can be addressed using competing risk regression models: first, which covariates affect the rate at which events occur, and second, which covariates affect the probability of an event occurring over time. The cause-specific hazard model estimates the effect of covariates on the rate at which events occur in subjects who are currently event-free...
November 30, 2017: Statistics in Medicine
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