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https://www.readbyqxmd.com/read/29026845/osteonecrosis-of-the-jaws-in-patient-received-bisphosphonates-and-sunitinib-separately-a-case-report
#1
Farzaneh Ashrafi, Ali Derakhshandeh, Bijan Movahedian, Azadeh Moghaddas
Recently published reports have suggested that antiangiogenic drugs such as sunitinib could potentiate the osteonecrosis of the jaw (ONJ) induced by bisphosphonates (BPs) and even induce this adverse effect per se. We reported a case of ONJ with renal cell carcinoma under sunitinib medication and history of BPs therapy. A 53-year-old man was referred to the oral surgery clinic complaining of painful exposed oral lesion and bone extraction from right lower jaw in the mouth. He underwent nephrectomy followed by 5 months treatment with cycles of 50 mg sunitinib (Sutent(®)) once a day for 4 weeks followed by 2 weeks drug free before lesion exposure in October 2016...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29020700/a-case-report-of-delayed-intra-abdominal-and-intra-luminal-haemorrhage-after-polypectomy
#2
Albrecht Neesse, Marian Grade, Sebastian Dango, Michael Ghadimi, Volker Ellenrieder, Steffen Kunsch, Ahmad Amanzada
We report the case of a 70-year-old man who presented with hematochezia, anaemia, and severe abdominal pain 6 days after polypectomy. Contrast-enhanced ultrasound and computed tomography revealed no signs of free intra-abdominal air but showed intra-abdominal and intra-luminal bleeding. The patient was referred to colonoscopy in the operation room, which showed a coagula and venous bleeding at the polypectomy site. Emergency laparotomy was performed and revealed a large intra-abdominal mesocolic hematoma, which was surgically removed...
October 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28985970/the-effects-of-actors-vocal-exercises-for-relaxation-on-fluency-a-preliminary-study
#3
Emily Monteagudo, Jean Sawyer, Alyssa Sivek-Eskra
PURPOSE: To determine the efficacy of treatment based on Kristin Linklater's technique for vocal preparation for performance for use with people who stutter. METHOD: A protocol for a treatment for stuttering involving breathing exercises, relaxation techniques, and focus on awareness was designed by the first author from Linklater's published exercises in her book Freeing the Natural Voice (2006). Four adults who stutter participated in a 12-week, single-case reversal design study...
September 18, 2017: Journal of Fluency Disorders
https://www.readbyqxmd.com/read/28980061/applications-of-contrast-enhanced-ultrasound-in-the-pediatric-abdomen
#4
Aikaterini Ntoulia, Sudha A Anupindi, Kassa Darge, Susan J Back
Contrast-enhanced ultrasound (CEUS) is a radiation-free, safe, and in specific clinical settings, highly sensitive imaging modality. Over the recent decades, there is cumulating experience and a large volume of published safety and efficacy data on pediatric CEUS applications. Many of these applications have been directly translated from adults, while others are unique to the pediatric population. The most frequently reported intravenous abdominal applications of CEUS in children are the characterization of focal liver lesions, monitoring of solid abdominal tumor response to treatment, and the evaluation of intra-abdominal parenchymal injuries in selected cases of blunt abdominal trauma...
October 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28975120/metastatic-gastrointestinal-stromal-tumor-a-regional-cancer-center-experience-of-44-cases
#5
M C Suresh Babu, Tamojit Chaudhuri, K Govind Babu, K C Lakshmaiah, D Lokanatha, Linu Abraham Jacob, A H Rudresha, K N Lokesh, L K Rajeev
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Historically, a poor prognosis for metastatic disease has been reported with systemic chemotherapy. Significant advances have been made in the last decade, since the introduction of different tyrosine kinase inhibitors (TKIs). Unfortunately, even though the TKIs have been used for a long time, there are very few published data of the experience of TKI therapy in metastatic GIST from India...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28962117/nearly-asymptomatic-intracranial-capillary-hemangiomas-a-case-report-and-literature-review
#6
Xiaoyu Xia, Haoju Zhang, Hongyan Gao, Yi Yang, Yiwu Dai, Yang Jiao, Jianghong He
The present study reported a nearly asymptomatic case of intracranial capillary hemangioma (ICHs), which are rare benign vascular tumors or tumor-like lesions. A 33-year-old female came to the hospital with a complaint of a slight but recurring morning headache concentrated in the left posterior occipital area. These headaches spontaneously resolved without any treatment. Computed tomography and magnetic resonance imaging revealed a mass inside the left occipital lobe. The patient refused to undergo conservative observation at home and insisted on radical therapy...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28946155/-lung-metastasectomy-in-pulmonary-metastatic-colorectal-carcinoma
#7
Sascha Macherey, Christiane Bruns, Hakan Alakus, Fabian Doerr, Matthias Heldwein, Alexander Quaas, Thorsten Wahlers, Khosro Hekmat
Background Patients with colorectal cancer are often affected by liver and lung metastases. Besides systemic therapies, lung metastasectomy is a suitable treatment option after complete resection of primary colorectal carcinoma and even concomitant liver metastases. Material and Methods We have performed a systematical literature research of all studies published after 01. 01. 2010. Studies reporting on at least 100 patients undergoing lung metastasectomy after 01. 01. 2000 have been included in our final analysis...
September 25, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28932354/cardiovascular-involvement-in-celiac-disease
#8
REVIEW
Edward J Ciaccio, Suzanne K Lewis, Angelo B Biviano, Vivek Iyer, Hasan Garan, Peter H Green
Celiac disease (CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small intestinal manifestations, including villous atrophy, as well as systemic manifestations. The main treatment for the disease is a gluten-free diet (GFD), which typically results in the restoration of the small intestinal villi, and restoration of other affected organ systems, to their normal functioning. In an increasing number of recently published studies, there has been great interest in the occurrence of alterations in the cardiovascular system in untreated CD...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28902964/plasmatic-coagulation-and-fibrinolysis-in-healthy-and-otostrongylus-affected-northern-elephant-seals-mirounga-angustirostris
#9
Sarrah Kaye, Shawn Johnson, Carlos Rios, Daniel J Fletcher
BACKGROUND: Prepatent Otostrongylus arteritis results in hemorrhagic diathesis in free-ranging Northern elephant seals (Mirounga angustirostris) attributed to aberrant larval migration of the lungworm, Otostrongylus circumlitus. Clinical signs are often nonspecific, including lethargy, anorexia, and blepharospasm, but can progress to spontaneous frank hemorrhage and death within 72 hours of onset. Previously published case reports describe coagulopathy with prolonged PT and APTT, normal to elevated platelet counts, normal antithrombin concentrations, and low concentrations of fibrinogen degradation products...
September 13, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28880439/complete-response-in-a-patient-with-stage-iv-adrenocortical-carcinoma-treated-with-adjuvant-trans-catheter-arterial-chemo-embolization-tace
#10
Eugene Wong, Sarah Jacques, Michael Bennett, Vineet Gorolay, Adrian Lee, Stephen Clarke
Adrenocortical carcinoma is a rare cancer, with estimate population incidence of 0.7-2.0 cases per 1 million each year. It also carries poor prognosis with estimated 5-year survival of less than 15% of those with metastatic disease and has a poor response to cytotoxic treatment. A randomized controlled trial published in 2012 by Fassnacht et al. demonstrated improved progression-free survival with first-line etoposide-doxirubicin-cisplatin-mitotane (EDP-M) compared to first-line streptozocin-mitotane in patients with stage III-IV disease...
September 6, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28874619/surgical-management-of-primary-and-recurrent-carcinoma-showing-thymous-like-elements-castle
#11
Federico Attene, Ilia Patrizia Pisano, Carlo Pala, Antonio Marrosu, Corrado Bozzo, Fabrizio Scognamillo
INTRODUCTION: Carcinoma showing thymous-like elements (CASTLE) is a rare tumor with only a few cases described in the scientific literature. The aim of the present review is to analyze the data available on the therapeutic options employed in CASTLE tumors and to outline the best surgical management to adopt. MATERIALS AND METHODS: English-language articles published from 1985 through November 2016, and related to CASTLE cases were retrieved using the Pubmed database and specific key-words...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28871357/-immunotherapy-as-modern-tumor-treatment
#12
REVIEW
C Grüllich
BACKGROUND: The specific immune system is capable of preventing the development of tumor diseases and stimulation of cytotoxic T‑lymphocytes can repress existing tumors. The activation of T‑lymphocytes is influenced by a new class of antibody-based medication, the immune checkpoint inhibitors. METHODS: Review of the scientific background and the published clinical trials on the activity and approval of immune checkpoint inhibitors for various tumor diseases...
September 4, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28851416/interim-analysis-of-survival-in-a-prospective-multi-center-registry-cohort-of-cutaneous-melanoma-tested-with-a-prognostic-31-gene-expression-profile-test
#13
Eddy C Hsueh, James R DeBloom, Jonathan Lee, Jeffrey J Sussman, Kyle R Covington, Brooke Middlebrook, Clare Johnson, Robert W Cook, Craig L Slingluff, Kelly M McMasters
BACKGROUND: A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of the GEP performance in patients enrolled in two clinical registries. METHODS: Three-hundred twenty two CM patients enrolled in the EXPAND (NCT02355587) and INTEGRATE (NCT02355574) registries met the criteria of age ≥ 16 years, successful GEP result and ≥1 follow-up visit for inclusion in this interim analysis...
August 29, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28843005/reconstruction-of-midface-defects-with-the-osteocutaneous-radial-forearm-flap-evaluation-of-long-term-outcomes-including-patient-reported-quality-of-life
#14
Timothy M Connolly, Larissa Sweeny, Benjamin Greene, Anthony Morlandt, William R Carroll, Eben L Rosenthal
BACKGROUND: Maxillectomy defects significantly impair quality of life. Prosthetics can overcome some of these issues, but has limitations. The role of the osteocutaneous radial forearm free flap (OC-RFFF) has been established for reconstruction of smaller maxillectomy defects, but its role in larger defects is not well defined. We aim to evaluate outcomes after midface reconstruction utilizing the OC-RFFF. METHODS: Retrospective review of prospective database collected between 2005 and 2014 of midface reconstruction using OC-RFFF in a tertiary care centre...
August 26, 2017: Microsurgery
https://www.readbyqxmd.com/read/28836092/four-symptoms-define-the-piriformis-syndrome-an-updated-systematic-review-of-its-clinical-features
#15
REVIEW
Kevork Hopayian, Armine Danielyan
PURPOSE: To update the evidence on the clinical features of the piriformis syndrome since the first systematic review published in 2010. METHOD: A systematic review of all case, cross-sectional and prevalence studies. RESULTS: The commonest features reported were: buttock pain, pain aggravated on sitting, external tenderness near the greater sciatic notch and pain on any maneuver that increases piriformis muscle tension, and limitation of straight leg raising...
August 23, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28832002/pointed-rhythmic-theta-waves-a-unique-eeg-pattern-in-kcnq2-related-neonatal-epileptic-encephalopathy
#16
Sarah Grace Buttle, Erick Sell, David Dyment, Srinivas Bulusu, Daniela Pohl
We report the case of an infant with KCNQ2-related neonatal epileptic encephalopathy presenting with intractable seizures beginning on the second day of life, which were resistant to multiple antiepileptic drugs. Continuous EEG recordings starting on the sixth day of life demonstrated a unique pattern of inter-and postictal focal rhythmic pointed theta waves of lambdoid morphology in the immediate postictal period, localizing to the side of the antecedent seizure. Interictal EEG exhibited discontinuous background, including patterns of burst suppression and multifocal discharges, predominantly in the centrotemporal regions, which were aggravated during sleep...
August 23, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28737562/dynamic-cleft-maxillary-orthopedics-and-periosteoplasty-25-patients-25-years
#17
Frederick N Lukash, Lauren B Shikowitz-Behr, Michael Schwartz, Frank Tuminelli
In 1985 this cleft team, dissatisfied with the treatment and results from cleft lip and palate repair, began a longitudinal long-term study using dynamic maxillary orthopedics and periosteoplasty as was originally described by Drs Millard and Latham. All cases were carefully documented through adolescence, including clinical assessments, orthodontic, radiographic, and cephalometric analyses. In 1998, in this journal, we published our data on 35 complete unilateral and 10 complete bilateral cleft patients. At that time facial growth was following normal cephalometric patterns...
July 22, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28732524/how-to-choose-the-best-journal-for-your-case-report
#18
EDITORIAL
Richard A Rison, Jennifer Kelly Shepphird, Michael R Kidd
Since the establishment of the Journal of Medical Case Reports in 2006, the number of journals that publish case reports has increased rapidly, and most of these journals are open access. Open access publishing usually requires authors to pay publication fees while offering the articles online, free of charge, and free of most copyright and licensing restrictions. The movement for open access has gained support in the research community, with the publishers BioMed Central and PLOS ONE becoming leaders in scientific publishing in their number of articles and citations...
July 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28730169/effects-of-s-1-combined-with-radiotherapy-in-the-treatment-of-nasopharyngeal-cancer-a-meta-analysis-based-on-randomized-controlled-trials
#19
Jin Fengtong, Fu Jiangtao, Wang Yating, Wu Lili, Chen Jianbo, Wang Xiaofei
The aim of this meta-analysis was to evaluate the effects and toxicity of S-1 combined with radiotherapy in the treatment of nasopharyngeal cancer (NPC). Through a search of the databases of PubMed, Embase, the Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang system and Chongqing VIP Information (CQVIP), the efficacy and side effects data of S-1 combined with radiotherapy in the treatment of NPC patients from open published randomized controlled trials (RCTs) were collected...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28716789/identification-of-the-delivery-of-cognitive-behavioural-therapy-for-psychosis-cbtp-using-a-cross-sectional-sample-from-electronic-health-records-and-open-text-information-in-a-large-uk-based-mental-health-case-register
#20
Craig Colling, Lauren Evans, Matthew Broadbent, David Chandran, Thomas J Craig, Anna Kolliakou, Robert Stewart, Philippa A Garety
OBJECTIVE: Our primary objective was to identify cognitive behavioural therapy (CBT) delivery for people with psychosis (CBTp) using an automated method in a large electronic health record database. We also examined what proportion of service users with a diagnosis of psychosis were recorded as having received CBTp within their episode of care during defined time periods provided by early intervention or promoting recovery community services for people with psychosis, compared with published audits and whether demographic characteristics differentially predicted the receipt of CBTp...
July 17, 2017: BMJ Open
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