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https://www.readbyqxmd.com/read/29030659/cyclophosphamide-could-be-a-better-choice-than-methotrexate-as-induction-treatment-for-patients-with-more-severe-takayasu-s-arteritis
#1
Ying Sun, Lili Ma, Lingying Ma, Xiufang Kong, Huiyong Chen, Peng Lv, Jiang Lin, Hao Liu, Yan Yan, Zongfei Ji, Chengde Yang, Shengming Dai, Weiguo Wan, Yaohong Zou, Xuejuan Jin, Lindi Jiang
To assess the effectiveness of cyclophosphamide (CYC) versus methotrexate (MTX) for active Takayasu's arteritis (TA). The current study was based on a cohort of TA at Zhongshan Hospital, Fudan University. TA was diagnosed using the 1990 American College of Rheumatology criteria. Fifty-eight subjects receiving induction treatment with CYC (n = 46) or MTX (N = 12) were included in the analysis. Effectiveness and toxicity were assessed in all 58 cases. Clinical remission was defined as: Kerr score reduction to ≤ 1 and glucocorticoids (GC) treatment at a dose of ≤ 0...
October 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29028843/efficiency-of-different-air-filter-types-for-pig-facilities-at-laboratory-scale
#2
Cindy Wenke, Janina Pospiech, Tobias Reutter, Uwe Truyen, Stephanie Speck
Air filtration has been shown to be efficient in reducing pathogen burden in circulating air. We determined at laboratory scale the retention efficiency of different air filter types either composed of a prefilter (EU class G4) and a secondary fiberglass filter (EU class F9) or consisting of a filter mat (EU class M6 and F8-9). Four filter prototypes were tested for their capability to remove aerosol containing equine arteritis virus (EAV), porcine reproductive and respiratory syndrome virus (PRRSV), bovine enterovirus 1 (BEV), Actinobacillus pleuropneumoniae (APP), and Staphylococcus (S...
2017: PloS One
https://www.readbyqxmd.com/read/29024993/ultrasonographic-findings-as-diagnostic-and-follow-up-tool-in-cranial-giant-cell-arteritis
#3
Yoshinori Taniguchi, Hirofumi Nishikawa, Eri Amano, Shimpei Fujimoto, Yoshio Terada
No abstract text is available yet for this article.
August 28, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29024675/tempo-ral-was-the-heart-of-the-matter
#4
Francesco Pellegrini, Daniele Cirone, Piernicola Machin, Rod Foroozan
A 71-year-old woman was admitted with fever, headache and weight loss associated with elevated inflammatory markers. She developed acute bilateral ophthalmoplegia and asymmetrical ptosis rapidly followed by anterior ischemic optic neuropathy. Although the first temporal artery biopsy (TAB) was negative, contralateral TAB revealed features consistent with giant cell arteritis. Even while under steroid therapy, the patient died a few days later from myocardial infarction. Acute bilateral complete ophthalmoplegia is a rare presentation of a limited number of possible diseases...
October 9, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29024426/c-reactive-protein-gene-polymorphisms-rs1205-in-asian-indian-patients-with-takayasu-arteritis-associations-and-phenotype-correlations
#5
Aswin M Nair, Ruchika Goel, Mohan Hindhumati, Krati Shah, Puneet Chandana, Visalakshi Jayaseelan, Kabeerdoss Jayakanthan, George Joseph, Sumita Danda, Debashish Danda
BACKGROUND/PURPOSE: Normal C-reactive protein (CRP) in active Takayasu arteritis (TA) is a dilemma. We attempted to validate our pilot study finding of rs1205 in CRP gene being protective against TA. METHODS: Genomic DNA of 104 patients and 185 sex-matched healthy controls were genotyped for rs1205 by Taqman assay. Clinical details, demography, angiographic and activity scores (Indian Takayasu arteritis score 2010) were recorded prospectively at baseline and during follow-up visits for 12 months...
October 11, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29023979/sox8-and-sox10-jointly-maintain-myelin-gene-expression-in-oligodendrocytes
#6
Tanja Turnescu, Juliane Arter, Simone Reiprich, Ernst R Tamm, Ari Waisman, Michael Wegner
In Schwann cells of the vertebrate peripheral nervous system, induction of myelination and myelin maintenance both depend on the HMG-domain-containing transcription factor Sox10. In oligodendrocytes of the central nervous system, Sox10 is also essential for the induction of myelination. Its role in late phases of myelination and myelin maintenance has not been studied so far. Here, we show that these processes are largely unaffected in mice that lack Sox10 in mature oligodendrocytes. As Sox10 is co-expressed with the related Sox8, we also analyzed oligodendrocytes and myelination in Sox8-deficient mice...
October 11, 2017: Glia
https://www.readbyqxmd.com/read/29021984/mri-findings-of-early-stage-hyperacute-hemorrhage-causing-extramedullary-compression-of-the-cervical-spinal-cord-in-a-dog-with-suspected-steroid-responsive-meningitis-arteritis
#7
Adriano Wang-Leandro, Enrice-Ina Huenerfauth, Katharina Heissl, Andrea Tipold
A 9-month-old female Weimaraner was presented to the emergency service due to episodes of fever and neck pain. Physical examination revealed a stiff neck posture and elevated body temperature. Shortly after clinical examination was performed, the dog developed peracute onset of non-ambulatory tetraparesis compatible with a C1-C5 spinal cord (SC) lesion. Immediately thereafter (<1 h), MRI of the cervical SC was performed with a 3-T scanner. A left ventrolateral intradural-extramedullary SC compression caused by a round-shaped structure at the level of C3--C4 was evidenced...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29020715/diagnosis-and-management-of-polymyalgia-rheumatica
#8
Olwyn Jones, Fraser Birrell
Polymyalgia rheumatica (PMR) is a common inflammatory condition of unknown aetiology with a prevalence of 1 in 133 in the over 50s, and a female to male ratio of 2:1. Symptoms develop over a matter of weeks; typically bilateral shoulder or pelvic girdle pain and stiffness, that is worse in the mornings. Associated symptoms include low-grade fever, malaise, fatigue, low mood, poor appetite, and weight loss. There is no specific diagnostic test for PMR but the usual pattern is a commensurate rise in CRP and ESR...
December 2016: Practitioner
https://www.readbyqxmd.com/read/29020600/trial-of-tocilizumab-in-giant-cell-arteritis
#9
LETTER
John H Stone, Micki Klearman, Neil Collinson
New England Journal of Medicine, Volume 377, Issue 15, Page 1493-1495, October 2017.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29020599/trial-of-tocilizumab-in-giant-cell-arteritis
#10
LETTER
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29020486/ocular-manifestations-and-visual-outcomes-of-beh%C3%A3-et-s-uveitis-in-a-thai-population
#11
Kessara Pathanapitoon, Paradee Kunavisarut, Fa-Arun Saravuttikul, Aniki Rothova
PURPOSE: To report on ocular manifestations and visual outcomes of Thai patients with Behçet's Uveitis (BU). METHODS: We reviewed medical records of 50 BU patients (31 males and 19 females). Ocular manifestations, treatment modalities, complications, and visual outcomes were registered. RESULTS: Ocular involvement was bilateral in 76% of patients, resulting in 89 affected eyes. Panuveitis and posterior uveitis were the most common types. Retinal vasculitis was noted in majority of affected eyes and specifically arteritis was noticed in 32/57(56%)...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29016409/anterior-ischemic-optic-neuropathy-due-to-calciphylaxis
#12
Magne S Sivertsen, Erik H Strøm, Kim M A Endre
A 72-year-old woman experienced anterior ischemic optic neuropathy in her left eye. The funduscopic and fluorescein angiographic findings were strongly suggestive of giant cell arteritis. Temporal artery biopsy revealed extensive calcification in the vessel wall consistent with calciphylaxis. This unusual disorder should be considered in the differential diagnosis of anterior ischemic optic neuropathy, particularly the arteritic form.
October 6, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28994265/recognition-of-giant-cell-arteritis-in-patients-with-polymyalgia-rheumatica-who-have-a-stroke-a-cautionary-tale
#13
Donald H Gutteridge, Frank L Mastaglia
An 82-year-old woman with polymyalgia rheumatica (PMR) on prednisone 7 mg daily was admitted to an acute stroke unit with a right homonymous hemianopia, a left posterior cerebral artery occlusion and occipital lobe infarct. She had raised inflammatory markers, did not have a temporal artery biopsy, and was discharged on the same dose of prednisone. After 21 months, off prednisone, her ophthalmologist, concerned about giant cell arteritis (GCA), restarted prednisone 40 mg daily, with rapid, profound visual improvement...
October 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28993535/teaching-neuroimages-giant-cell-arteritis-presenting-with-acute-ischemic-strokes-due-to-diffuse-intracranial-stenoses
#14
Odysseas Kargiotis, Apostolos Safouris, Vasileios N Petrou, Georgios Magoufis, Eleftherios Stamboulis, Georgios Tsivgoulis
No abstract text is available yet for this article.
October 10, 2017: Neurology
https://www.readbyqxmd.com/read/28990239/tacrolimus-therapy-for-dermal-arteritis-of-the-nasal-philtrum-refractory-to-surgery-and-anti-inflammatory-therapy-doxycycline-niacinamide-and-topical-fluocinolone-in-a-dog
#15
Frane Banovic, Carmen Jerry, Elizabeth Howerth
BACKGROUND: Dermal arteritis of the nasal philtrum is a rarely reported condition commonly affecting large breed dogs. OBJECTIVE: To describe the effective treatment of nasal philtrum arteritis with topical tacrolimus in one dog. ANIMAL: A 9-year-old, intact male German shorthair pointer dog was presented with well-demarcated deep erythematous ulcers targeting exclusively the skin of the nasal philtrum, accompanied by frequent series of haemorrhage...
October 8, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28987704/the-role-of-colour-doppler-ultrasonography-of-facial-and-occipital-arteries-in-patients-with-giant-cell-arteritis-a-prospective-study
#16
Rok Ješe, Žiga Rotar, Matija Tomšič, Alojzija Hočevar
OBJECTIVE: Colour Doppler Sonography (CDS) in giant cell arteritis (GCA) allows the study of involvement of cranial arteries other than the temporal arteries, which are inconvenient to biopsy, such as the facial (FaA), and occipital (OcA) arteries. We aimed to estimate the frequency of the FaA, and OcA involvement in GCA; and to explore the clinical characteristics of these subgroups of patients. METHODS: From 1 January 2014 to 31 December 2016 we prospectively performed a CDS of the FaA, and OcA in addition to the temporal (TA), and the extracranial supra-aortic arteries in all newly diagnosed patients suspected of having GCA...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28985704/extracorporeal-membrane-oxygenation-for-kawasaki-disease-two-case-reports-and-the-extracorporeal-life-support-organization-experience-1999-2015
#17
Derek Best, Johnny Millar, Igor Kornilov, Yury Sinelnikov, Roberto Chiletti, Peter Rycus, Warwick Butt
Kawasaki disease is usually a limited illness of early childhood. However, life-threatening cardiac manifestations can occur, either at acute presentation or as a consequence of coronary arterial involvement. We report the successful use of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) for cardiac support in two children with Kawasaki disease: one with acute Kawasaki disease shock syndrome, the other with complications of coronary arteritis and subsequent surgery. We also reviewed the reported experience in the ELSO database and available literature...
October 2017: Perfusion
https://www.readbyqxmd.com/read/28983940/outline-of-guidelines-for-the-management-of-vasculitis-and-vascular-disorders-in-japan-2016-revised-edition
#18
Takaharu Ikeda, Fukumi Furukawa, Tamihiro Kawakami, Naoko Ishiguro, Miwa Uzuki, Shoichi Ozaki, Kensei Katsuoka, Takeshi Kono, Seiji Kawana, Masanari Kodera, Takashi Sawai, Yasuyuki Sawada, Mariko Seishima, Akiko Tanikawa, Ko-Ron Chen, Minoru Hasegawa
The proposal by the 1994 International Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitides (CHCC1994) and by the CHCC2012 markedly influenced the classification and way of considering cutaneous vasculitis. In the proposal by the CHCC1994, hypersensitivity angiitis was defined as an equivalent pathological condition to microscopic polyangiitis or cutaneous leukocytoclastic angiitis (CLA), and it was not adopted as a disease name. However, CLA which was positioned as a type of small-vessel vasculitis is only a pathological name...
October 6, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28980910/health-related-outcomes-of-importance-to-patients-with-takayasu-s-arteritis
#19
Antoine G Sreih, Fatma Alibaz-Oner, Ebony Easley, Trocon Davis, Gonca Mumcu, Nataliya Milman, Joanna Robson, Haner Direskeneli, Peter A Merkel, Peter Cronholm
OBJECTIVES: The need to include patients' perspectives as key outcomes in clinical trials is widely accepted. No disease-specific patient-reported outcomes have been developed in Takayasu's arteritis. This project was designed to identify outcomes of importance to patients with Takayasu's arteritis during active disease and remission across 2 different cultures. METHODS: Patients with Takayasu's arteritis from the US and Turkey were recruited to participate in semi-structured, one-on-one interviews or focus groups...
September 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28977672/rituximab-therapy-for-takayasu-arteritis-a-seven-patients-experience-and-a-review-of-the-literature
#20
Giulia Pazzola, Francesco Muratore, Nicolò Pipitone, Filippo Crescentini, Patrice Cacoub, Luigi Boiardi, Lucia Spaggiari, Cloe Comarmond, Stefania Croci, David Saadoun, Carlo Salvarani
Objectives: To assess the efficacy and safety of rituximab (RTX) in patients with Takayasu arteritis (TAK). Methods: We conducted a retrospective study on seven TAK patients treated with RTX. Six of the seven patients had a disease refractory to high dose glucocorticoids and conventional immunosuppressive and/or biologic agents. One newly diagnosed, treatment-naïve TAK patient refused glucocorticoids and received RTX alone. Clinical evaluation, laboratory tests and imaging modalities (CT or MR-angiography, and 18 F-fluorodeoxyglucose PET/CT) were performed at first RTX administration and every 6 months thereafter...
July 18, 2017: Rheumatology
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