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https://www.readbyqxmd.com/read/29221884/-efficacy-and-tolerance-of-tocilizumab-for-corticosteroid-sparing-in-giant-cell-arteritis-and-aortitis-experience-of-nimes-university-hospital-about-eleven-patients
#1
J Broner, E Arnaud
INTRODUCTION: Giant cell arteritis is a large-vessels vasculitis, which treatment consists in a slowly-tappered steroid-therapy. Immunosuppressive agents are sometimes used in case of steroid-dependance. We have conducted an observationnal retrospective study including patients treated with tocilizumab for a giant cell arteritis or an aortitis in the internal medicine department at the Nîmes University Hospital. RESULTS: Eleven patients were included between 2011 and 2016, who had been treated only with prednisone...
December 5, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29219653/characteristics-and-outcome-of-intractable-vasculitis-syndrome-in-children-nation-wide-survey-in-japan
#2
Naoko Nakano, Masaaki Mori, Hiroaki Umebayashi, Naomi Iwata, Norimoto Kobayashi, Kenji Masunaga, Tomoyuki Imagawa, Takuji Murata, Noriko Kinjo, Kazushige Nagai, Mari Miyoshi, Syuji Takei, Shumpei Yokota, Eiichi Ishii
OBJECTIVE: Primary systemic vasculitis (PSV) is a rare disorder in children and difficult to distinguish from other diseases. However, appropriate diagnosis and prompt treatment will affect on the morbidity and mortality of intractable PSV. In this study, we conducted a nationwide survey in Japan, to clarify epidemiology and clinical outcome of PSV. METHODS: We had sent survey questionnaires to most of the Japanese institutions that employed pediatricians, requesting the number of patients with refractory PSV who were diagnosed and treated between 2007 and 2011...
December 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29217104/-does-tocilizumab-mean-the-end-of-glucocorticoids-in-giant-cell-arteritis
#3
M Samson, B Bonnotte
No abstract text is available yet for this article.
December 4, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29217029/development-of-a-predictive-model-for-temporal-artery-biopsies
#4
Ezekiel Weis, Andrew Toren, David Jordan, Vivek Patel, Steven Gilberg
OBJECTIVE: Temporal artery biopsy is a critical, relatively safe, and reliable test in the diagnosis of temporal arteritis. Yet, a clarification of the pre-test probabilities may provide clarity on which patients with suspected giant cell arteritis would benefit from this invasive diagnostic procedure. DESIGN: A prospective case series PARTICIPANTS: A consecutive case series of patients referred to the Ophthalmology service for temporal artery biopsy. METHODS: All subjects underwent standardized serum testing, and signs and symptoms assessment...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29210708/takayasu-arteritis-and-complete-aortic-arch-branch-vessel-occlusions
#5
Shane M Gillespie, Stephen M Broski, David W Barbara
No abstract text is available yet for this article.
November 28, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29208249/aortic-aneurysm-in-takayasu-arteritis
#6
Kun-Qi Yang, Xu Meng, Ying Zhang, Peng Fan, Lin-Ping Wang, Hui-Min Zhang, Hai-Ying Wu, Xiong-Jing Jiang, Jun Cai, Xian-Liang Zhou, Ru-Tai Hui, De-Yu Zheng, Li-Sheng Liu
BACKGROUND: Aortic aneurysm (AA) is a severe complication of Takayasu arteritis (TA). This study aimed to evaluate the prevalence, clinical and imaging features, management and long-term outcomes of AA in patients with TA. MATERIALS AND METHODS: A retrospective study was performed of TA patients with AA admitted to Fuwai Hospital from 1996-2015. Baseline clinical data and follow-up data of TA patients with AA were collected and analyzed. RESULTS: Thirty-nine (4...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29208247/assessing-the-risk-of-aortic-aneurysm-in-takayasu-arteritis
#7
EDITORIAL
Jose A Leon de la Rocha, Luis R Espinoza
No abstract text is available yet for this article.
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29206350/isolated-v-lesion-in-kidney-transplant-recipients-characteristics-association-with-dsa-and-histological-follow-up
#8
Marion Rabant, Fanny Boullenger, Viviane Gnemmi, Gaëlle Pellé, François Glowacki, Alexandre Hertig, Isabelle Brocheriou, Caroline Suberbielle, Jean-Luc Taupin, Dany Anglicheau, Christophe Legendre, Jean-Paul Duong Van Huyen, David Buob
Isolated v-lesion (IvL) represents a rare and challenging situation in renal allograft biopsies because it is unknown whether IvL truly represents rejection, antibody- or T cell-mediated, or not. This multicentric retrospective study describes the clinicopathological features of IvL with an emphasis on the Donor Specific Antibodies (DSA) status, histological follow-up, and graft survival. Inclusion criteria were the presence of v-lesion with minimal interstitial (i≤1) and microvascular inflammation (g+ptc≤1)...
December 5, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29203437/effect-of-alcohol-based-hand-rub-on-hand-microbiome-and-hand-skin-health-in-hospitalized-adult-stem-cell-transplant-patients-a-pilot-study
#9
Pranab K Mukherjee, Jyotsna Chandra, Mauricio Retuerto, Karen A Arters, Mary C Consolo, A'ja Patterson, Saralee Bajaksouzian, James W Arbogast, Todd J Cartner, Michael R Jacobs, Mahmoud A Ghannoum, Robert A Salata
No abstract text is available yet for this article.
December 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29200816/multivariable-prediction-model-for-suspected-giant-cell-arteritis-development-and-validation
#10
Edsel B Ing, Gabriela Lahaie Luna, Andrew Toren, Royce Ing, John J Chen, Nitika Arora, Nurhan Torun, Otana A Jakpor, J Alexander Fraser, Felix J Tyndel, Arun Ne Sundaram, Xinyang Liu, Cindy Ty Lam, Vivek Patel, Ezekiel Weis, David Jordan, Steven Gilberg, Christian Pagnoux, Martin Ten Hove
Purpose: To develop and validate a diagnostic prediction model for patients with suspected giant cell arteritis (GCA). Methods: A retrospective review of records of consecutive adult patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at seven university centers. The pathologic diagnosis was considered the final diagnosis. The predictor variables were age, gender, new onset headache, clinical temporal artery abnormality, jaw claudication, ischemic vision loss (VL), diplopia, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelet level...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29198655/clinical-and-pathological-analyses-of-cases-of-acute-vascular-rejection-after-kidney-transplantation
#11
T Shimizu, H Ishida, N Hayakawa, R Shibahara, K Tanabe
BACKGROUND: We performed a clinical and pathological analysis of cases of acute vascular rejection (AVR), characterized by intimal arteritis and transmural arteritis (Banff v score) after kidney transplantation, in an attempt to clarify the mechanisms underlying the development and prognostic significance of AVR. METHODS: AVR (Banff score: v >0) was diagnosed in 31 renal allograft biopsy specimens (BS) obtained from 31 renal transplant patients receiving follow-up care at the Department of Urology, Tokyo Women's Medical University, between January 2010 and April 2016...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198409/ischemic-complications-in-takayasu-s-arteritis-a-meta-analysis
#12
REVIEW
Hyein Kim, Lillian Barra
OBJECTIVES: Takayasu's arteritis (TAK) is a rare vasculitis affecting the large blood vessels with significant morbidity and mortality from ischemic complications. The objective of this meta-analysis is to determine the proportion of TAK patients with severe ischemic complications. METHODS: We performed a literature search using MEDLINE, EMBASE, and the Cochrane library from database inception to March 2016. We included articles that reported at least one severe ischemic complication...
November 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29196802/study-of-serial-serum-myeloid-related-protein-8-14-as-a-sensitive-biomarker-in-takayasu-arteritis-a-single-centre-study
#13
Ruchika Goel, Aswin Nair, Jayakanthan Kabeerdoss, Hindhumathi Mohan, Visalakshi Jeyaseelan, George Joseph, Debashish Danda
The aim of the study was to explore utility of serial serum myeloid-related protein 8/14 (MRP8/14) as a biomarker of clinical disease activity and angiographic progression in Takayasu arteritis (TA). Serum MRP8/14 levels were assayed by commercial ELISA for 85 TA patients and 24 healthy controls at baseline, and for 56 and 21 TA patients during follow-up visits R1 and R2, respectively. Disease was categorised as active, indeterminate and stable according to Indian Takayasu Arteritis score (ITAS 2010), ITAS-A(CRP) and angiography...
December 1, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29196543/fluorodeoxyglucose-positron-emission-tomography-for-giant-cell-arteritis
#14
EDITORIAL
Daniel Blockmans
No abstract text is available yet for this article.
December 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29196244/a-concise-review-of-significantly-modified-serological-biomarkers-in-giant-cell-arteritis-as-detected-by-different-methods
#15
REVIEW
B Burja, T Kuret, S Sodin-Semrl, K Lakota, Ž Rotar, R Ješe, K Mrak-Poljsak, P Žigon, G G Thallinger, J Feichtinger, S Čučnik, M Tomšič, S Praprotnik, A Hocevar
Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large and medium sized arteris. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA...
November 28, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29191819/efficacy-and-safety-of-tocilizumab-in-patients-with-refractory-takayasu-arteritis-results-from-a-randomised-double-blind-placebo-controlled-phase-3-trial-in-japan-the-takt-study
#16
Yoshikazu Nakaoka, Mitsuaki Isobe, Syuji Takei, Yoshiya Tanaka, Tomonori Ishii, Shumpei Yokota, Akira Nomura, Seitaro Yoshida, Norihiro Nishimoto
OBJECTIVE: To investigate the efficacy and safety of the interleukin-6 receptor antibody tocilizumab in patients with Takayasu arteritis (TAK). METHODS: Patients with TAK who had relapsed within the previous 12 weeks were induced into remission with oral glucocorticoid therapy. In this double-blind, placebo-controlled trial, patients were randomly assigned 1:1 to receive weekly tocilizumab 162 mg or placebo subcutaneously, and oral glucocorticoids were tapered 10 %/week from week 4 to a minimum of 0...
November 30, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29186538/the-potential-for-dual-pathology-in-temporal-arteritis
#17
Oscar M P Jolobe
No abstract text is available yet for this article.
November 24, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29186088/giant-cell-temporal-arteritis-with-persistent-bilateral-sensorineural-hearing-loss-a-likely-consequence-of-delayed-institution-of-glucocorticoid-therapy
#18
Shoaib Junejo, Yasir Ali, Adriana Abrudescu
No abstract text is available yet for this article.
November 22, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29183677/contribution-of-18f-fdg-pet-ct-in-the-diagnosis-of-recurrence-of-takayasu-s-arteritis
#19
A Cabrera Villegas, A F Elena Ibañez, I E Sánchez Rodriguez, M P Garrastachu Zumaran, P Santos Holgueras, M C Albornoz Almada
No abstract text is available yet for this article.
November 25, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29180268/takayasu-arteritis-in-young-women-with-acute-ischemic-heart-disease-time-to-shift-from-anecdote-to-clinical-practice
#20
EDITORIAL
Fulvio Salvo
No abstract text is available yet for this article.
November 23, 2017: International Journal of Cardiology
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